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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTBP2 Gene

protein-coding   GIFtS: 60
GCID: GC10M126666

C-terminal binding protein 2
 Explore 9 diseases affiliated with
CTBP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CTBP2    

Aliases
for CTBP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
C-Terminal Binding Protein 22 11
Ribeye1
C-Terminal-Binding Protein 22
CtBP23

External Ids:    HGNC: 24951   Entrez Gene: 14882   Ensembl: ENSG000001750297   OMIM: 6026195   UniProtKB: P565453   

Export aliases for CTBP2 gene to outside databases

Previous GC identifers: GC10P058330 GC10M125880 GC10M126717 GC10M126251 GC10M120363


Summaries
for CTBP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CTBP2:
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor,
while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain
a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region
was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are
likely. Blast analysis shows that this gene is present on chromosome 10. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CTBP2_HUMAN, P56545
Function: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT)
differentiation (By similarity)
Function: Isoform 2 probably acts as a scaffold for specialized synapses

Gene Wiki entry for CTBP2


Genomic Views
for CTBP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTBP2 gene promoter:
         AREB6   p300   IRF-7A   Nkx2-5   AP-2alpha   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CTBP2 promoter sequence

   Search SABiosciences Chromatin IP Primers for CTBP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.13
Nature(405: 311-319) cytogenetic band:   21q22.11
CTBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTBP2 gene location
GeneLoc information about chromosome 10         GeneLoc Exon Structure

(about GC identifiers)
GC10M126666:   GeneLoc Nature:405,311-319
Start:
 126,676,418 bp from pter       18,619,970 bp from centromere
End:
 126,849,739 bp from pter 18,650,793 bp from centromere
Size:
 173,322 bases 30,824 bases
Orientation:
 minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AF016507
genomic clones: pS322 pPQ119B8


Proteins
for CTBP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CTBP2_HUMAN, P56545 (See protein sequence)
Recommended Name: C-terminal-binding protein 2  
Size: 445 amino acids; 48945 Da
Subunit: Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and
CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes
expression (By similarity). Interacts with PNN, NRIP1 and WIZ
Subcellular location: Nucleus (Potential). Cell junction, synapse (By similarity)
1 PDB 3D structure from and Proteopedia for CTBP2:
2OME (3D)    
Secondary accessions: A8K2X5 D3DRF5 O43449 Q5SQP7 Q69YI3 Q86SV0 Q9H2T8
Alternative splicing: 2 isoforms:  P56545-1   P56545-2   (Ref.2 (AAG45951) sequence is in conflict in positions: 455:Y->H, 539:Q->E)

Explore the universe of human proteins at neXtProt for CTBP2: NX_P56545

Post-translational modifications:

  • Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR at Thr-179; Ser-181 and Ser-185. Phosphorylation by
    • HIPK2 on Ser-428 induces proteasomal degradation (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56545

    • CTBP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001077383.1  NP_001320.1  NP_073713.2  

    ENSEMBL proteins: 
     ENSP00000338615   ENSP00000311825   ENSP00000357816   ENSP00000434630   ENSP00000436285  
     ENSP00000410474   ENSP00000434424  

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    Novus Biologicals CTBP2 Proteins
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    Uscn Proteins for CTBP2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0017053transcriptional repressor complex ISS--
    GO:0030054cell junction IEA--
    GO:0045202synapse IEA--


    CTBP2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CTBP2

    Protein Domains /
    Families
    for CTBP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CTBP2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006140 D-isomer_2_OHA_DH_NAD-bd
     IPR006139 D-isomer_2_OHA_DH_cat_dom
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P56545

    ProtoNet protein and cluster: P56545

    1 Blocks protein family: IPB006139 D-isomer specific 2-hydroxyacid dehydrogenase

    UniProtKB/Swiss-Prot: CTBP2_HUMAN, P56545
    Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family


    Function
    for CTBP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CTBP2_HUMAN, P56545
    Function: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT)
    differentiation (By similarity)
    Function: Isoform 2 probably acts as a scaffold for specialized synapses

         Genatlas biochemistry entry for CTBP2:
    C terminal binding phosphoprotein 2,ubiquitously expressed with 2 higher level in heart,skeletal
    muscle,pancreas,associating to adenovirus E1A,C terminal proteins,involved with histone deacetylase and E2F3 in
    transcription repression

    miRNA
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    hsa-miR-411* hsa-miR-300 hsa-miR-376b hsa-miR-200a hsa-miR-578 hsa-miR-342-3p hsa-miR-3122 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmid: CTBP2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI--
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA--
    GO:0051287NAD binding IEA--


    CTBP2 for ontologies           About GeneDecksing


    Animal Models:
         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ctbp2):
     cardiovascular system  embryogenesis  growth/size  mortality/aging  muscle 
     nervous system  skeleton 

    CTBP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CTBP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt Signaling Pathway NetPath0.22
    		Wnt signaling pathway0.30
    2Notch Signaling Pathway
    		Notch Signaling Pathway1.00
    		Notch signaling pathway0.82
    3Neural Crest Differentiation
    		Neural Crest Differentiation1.00
    4SMAD Signaling Network
    		SMAD Signaling Network1.00
    5Chronic myeloid leukemia
    		Chronic myeloid leukemia1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CTBP2
        SMAD Signaling Network
    GSK3 Signaling

    4 BioSystems Pathways for CTBP2 
        Notch Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Neural Crest Differentiation
    Wnt Signaling Pathway NetPath


    4         Kegg Pathways  (Kegg details for CTBP2):
        Wnt signaling pathway
    Notch signaling pathway
    Pathways in cancer
    Chronic myeloid leukemia


    CTBP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/98 Interacting proteins for CTBP2 (P565451, 2, 3 ENSP000003118254) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIC1Q145261, 3, ENSP000003140804EBI-741533,EBI-2507362 I2D: score=2 STRING: ENSP00000314080
    ZNF512BQ96KM62, 3MINT-60818 I2D: score=2 
    BCL3P207491, 3, ENSP000001642274EBI-741533,EBI-958997 I2D: score=1 STRING: ENSP00000164227
    AKTIPQ9H8T03, ENSP000003002454I2D: score=4 STRING: ENSP00000300245
    ZEB1P372753, ENSP000003192484I2D: score=4 STRING: ENSP00000319248
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0008285negative regulation of cell proliferation TAS9479502
    GO:0019079viral genome replication TAS9479502
    GO:0045892negative regulation of transcription, DNA-dependent ISS--
    GO:0050872white fat cell differentiation ISS--


    CTBP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CTBP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CTBP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CTBP2
    2 Novoseek chemical compound relationships for CTBP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadh 53 4 15037661 (2), 16762039 (1)
    zinc 39.8 2 10567582 (1), 10801815 (1)

    Search CenterWatch for drugs/clinical trials and news about CTBP2 

    Transcripts
    for CTBP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CTBP2 gene (3 alternative transcripts): 
    NM_001083914.1  NM_001329.2  NM_022802.2  

    Unigene Cluster for CTBP2:

    C-terminal binding protein 2
    Hs.501345  [show with all ESTs]
    Unigene Representative Sequence: NM_022802
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337195(uc001lid.4 uc009yak.3 uc009yal.3 uc001lif.4 uc001lih.4)
    ENST00000309035(uc001lie.4) ENST00000334808 ENST00000531469 ENST00000494626
    ENST00000411419 ENST00000395705 ENST00000486955 ENST00000460976 ENST00000459668
    ENST00000493552 ENST00000476817 ENST00000530884 ENST00000530930 ENST00000467395


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    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate CTBP2 (see all 74):
    hsa-miR-411* hsa-miR-300 hsa-miR-376b hsa-miR-200a hsa-miR-578 hsa-miR-342-3p hsa-miR-3122 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmid: CTBP2 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF016507.1 AF222711.1 AK024129.1 AK290390.1 AL833398.1 BC002486.2 BC037900.2 BC047018.1 
    BC052276.1 BC072020.1 BT007012.1 DQ250324.1 

    24/30 DOTS entries (see all 30):

    DT.449458  DT.100795066  DT.121277015  DT.100795075  DT.121277044  DT.100795068  DT.100795065  DT.102838708 
    DT.100795069  DT.121277083  DT.121277155  DT.120852815  DT.121276918  DT.121276975  DT.40205746  DT.91708776 
    DT.91762442  DT.100795070  DT.102838706  DT.95189692  DT.100030928  DT.121277124  DT.121433723  DT.91934053 

    24/413 AceView cDNA sequences (see all 413):

    AI654311 AI083845 BM854719 AI985141 AL833398 W49714 BQ925485 R85455 
    AA996079 BQ426009 CA436702 AI274217 AI753198 BG111585 AI125221 BM465756 
    F10935 AA255465 AI632399 AW779009 AI827385 AI474785 AA865950 AI581135 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CTBP2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                                                                -                                       
    SP2:                                                                                -                                       
    SP3:                                                                                -                                       
    SP4:                                                                                                                        
    SP5:        -     -     -                                                                                                   


    ECgene alternative splicing isoforms for CTBP2

    Expression
    for CTBP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGGGATCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CTBP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTBP2

    SOURCE GeneReport for Unigene cluster: Hs.501345

    UniProtKB/Swiss-Prot: CTBP2_HUMAN, P56545
    Tissue specificity: Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including CTBP2: 
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              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    In Situ
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    Orthologs
    for CTBP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for CTBP2 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CTBP21 C-terminal binding protein 2 73.59(n)
    75.55(a)    		   423958  XM_421817.3  XP_421817.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 94(a)
    		 1 → many
    		 3(62311319-62361245)
    zebrafish
    (Danio rerio)    		 Actinopterygii AB032416.12   -- 80.93(n)   65230  AB032416.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CtBP1 , 3 negative regulation of transcription from
    Pol more3
    C-terminal Binding Protein1    		 72(a)3
    63.49(n)1
    67.48(a)1    		   87D93
    416021  NM_001014617.11  NP_001014617.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea F49E10.53 dehydrogenase 52(a)   X(5898026-5908015)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G721906
    		 D-isomer specific 2-hydroxyacid dehydrogenase-like...
    		 22(a)
    		 1 → many
    		 1(27167363-27169717)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 erythronate-4-phosphate dehydrogenase domain conta...
    erythronate-4-phosphate dehydrogenase domain conta...
    		 18(a)
    18(a)
    		 many ↔ many
    many ↔ many
    		 7(9352047-9356795)
    7(9296739-9299506)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria ghrA6
    		 glyoxylate/hydroxypyruvate reductase A
    		 19(a)
    		 possible ortholog
    		 Chromosome(1097109-1098047)


    ENSEMBL Gene Tree for CTBP2 (if available)
    TreeFam Gene Tree for CTBP2 (if available) 

    Paralogs
    for CTBP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTBP2 gene
    CTBP12  PHGDH2  ENSG000002128842  
    1 SIMAP similar gene for CTBP2 using alignment to 3 protein entries:     CTBP2_HUMAN (see all proteins):
    CTBP1

    CTBP2 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for CTBP2 (see all 8)
    PGOHUM00000238591 PGOHUM00000242652 PGOHUM00000235082 PGOHUM00000234295 PGOHUM00000244063


    Genomic Variants
    for CTBP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3932 NCBI SNPs in CTBP2 are shown (see all 3932)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1384873861,2
    		C,--126675931(+) AAATT-/TATATAT 4 -- ut31 ds50010--------
    rs2002629341,2
    		C--126675948(-) AAAATA/TTATAT 4 -- ds5001 ut310--------
    rs1908602941,2
    		--126675980(+) ATAATC/TAAAAC 4 -- ds5001 ut310--------
    rs1842392821,2
    		--126676036(+) CTTAGA/GTTCAT 4 -- ds50010--------
    rs1459204411,2
    		--126676245(+) TGGTAA/GAGTTG 4 -- ds50010--------
    rs1887899171,2
    		--126676291(+) AAGGCC/TAGGCA 4 -- ds50010--------
    rs1384789931,2
    		--126676387(+) TACCTA/GGAATT 4 -- ds50010--------
    rs1925579031,2
    		--126676483(+) ACTCAC/TGGGAC 4 -- ds5001 ut310--------
    rs1455004261,2
    		C,--126676517(+) TTTTG-/TTTTTGT 3 -- ut310--------
    rs38326991,2
    		C,--126676634(-) AAAAA-/ACAAAG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CTBP2 (126676418 - 126849739 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CTBP2
         3 CNVs: 43686 5617 43562

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for CTBP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CTBP2 for disorders           About GeneDecksing

    OMIM gene information: 602619    OMIM disorders: --

    9 diseases for CTBP2:    About MalaCards
    chronic myeloid leukemia    myeloid leukemia    prostate cancer    alzheimer's disease
    leukemia    prostatitis    breast cancer    hypoxia
    retinitis

    Human Genome Epidemiology (HuGE) Navigator: CTBP2 (25 documents)

    Export disorders for CTBP2 gene to outside databases

    Publications
    for CTBP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTBP2 gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with CTBP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. (PubMed id 9479502)1, 2, 3, 9 Katsanis N. and Fisher E.M.C. (1998)
    2. Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition. (PubMed id 15060175)1, 2, 9 Castet A.... Cavailles V. (2004)
    3. RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function. (PubMed id 11163272)1, 2, 9 Schmitz F.... Suedhof T.C. (2000)
    4. Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. (PubMed id 16702210)1, 2 Ueda J.... Shinkai Y. (2006)
    5. Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. (PubMed id 15542832)1, 2 Alpatov R.... Sugrue S.P. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. CtBP, an unconventional transcriptional corepressor in development and oncogenesis. (PubMed id 11864595)1, 3 Chinnadurai G. (2002)
    8. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. (PubMed id 7479821)1, 2 Schaeper U....Chinnadurai G. (1995)
    9. Acetylation by p300 regulates nuclear localization and function of the transcriptional corepressor CtBP2. (PubMed id 16356938)1, 9 Zhao L.J....Chinnadurai G. (2006)
    10. Interaction of ZEB and histone deacetylase with the P LDLS-binding cleft region of monomeric C-terminal binding protein 2. (PubMed id 19754958)1, 9 Zhao L.J....Chinnadurai G. (2009)

    External Searches for CTBP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CTBP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1488 HGNC: 2495 AceView: CTBP2 Ensembl:ENSG00000175029 euGenes: HUgn1488
    ECgene: CTBP2 Kegg: 1488 H-InvDB: CTBP2

    Other Databases showing CTBP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CTBP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTBP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTBP2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CTBP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CTBP2 gene:
    Search GeneIP for patents involving CTBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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