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Aliases for CTBP2 Gene

Aliases for CTBP2 Gene

  • C-Terminal Binding Protein 2 2 3
  • Ribeye 3
  • CtBP2 4

External Ids for CTBP2 Gene

Previous GeneCards Identifiers for CTBP2 Gene

  • GC10P058330
  • GC10M125880
  • GC10M126717
  • GC10M126251
  • GC10M126666
  • GC10M120363

Summaries for CTBP2 Gene

Entrez Gene Summary for CTBP2 Gene

  • This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CTBP2 Gene

CTBP2 (C-Terminal Binding Protein 2) is a Protein Coding gene. Diseases associated with CTBP2 include congenital stationary night blindness. Among its related pathways are Signaling by GPCR and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is CTBP1.

UniProtKB/Swiss-Prot for CTBP2 Gene

  • Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).

  • Isoform 2 probably acts as a scaffold for specialized synapses

Gene Wiki entry for CTBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTBP2 Gene

Genomics for CTBP2 Gene

Regulatory Elements for CTBP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTBP2 Gene

124,984,317 bp from pter
125,161,170 bp from pter
176,854 bases
Minus strand

Genomic View for CTBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for CTBP2 Gene

Proteins for CTBP2 Gene

  • Protein details for CTBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-terminal-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K2X5
    • D3DRF5
    • O43449
    • Q5SQP7
    • Q69YI3
    • Q86SV0
    • Q9H2T8

    Protein attributes for CTBP2 Gene

    445 amino acids
    Molecular mass:
    48945 Da
    Quaternary structure:
    • Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression (By similarity). Interacts with PNN, NRIP1 and WIZ. Interacts with human adenovirus 5 E1A protein; this interaction seems to potentiate viral replication (PubMed:23747199).

    Three dimensional structures from OCA and Proteopedia for CTBP2 Gene

    Alternative splice isoforms for CTBP2 Gene


neXtProt entry for CTBP2 Gene

Proteomics data for CTBP2 Gene at MOPED

Post-translational modifications for CTBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CTBP2 (CTBP2)

No data available for DME Specific Peptides for CTBP2 Gene

Domains & Families for CTBP2 Gene

Suggested Antigen Peptide Sequences for CTBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  • Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
genes like me logo Genes that share domains with CTBP2: view

No data available for Gene Families for CTBP2 Gene

Function for CTBP2 Gene

Molecular function for CTBP2 Gene

GENATLAS Biochemistry:
C terminal binding phosphoprotein 2,ubiquitously expressed with 2 higher level in heart,skeletal muscle,pancreas,associating to adenovirus E1A,C terminal proteins,involved with histone deacetylase and E2F3 in transcription repression
UniProtKB/Swiss-Prot Function:
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 2 probably acts as a scaffold for specialized synapses

Gene Ontology (GO) - Molecular Function for CTBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003713 transcription coactivator activity IEA --
GO:0003714 transcription corepressor activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA --
genes like me logo Genes that share ontologies with CTBP2: view
genes like me logo Genes that share phenotypes with CTBP2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTBP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CTBP2 Gene

Localization for CTBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTBP2 Gene

Nucleus. Cell junction, synapse.

Subcellular locations from

Jensen Localization Image for CTBP2 Gene COMPARTMENTS Subcellular localization image for CTBP2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0017053 transcriptional repressor complex ISS --
GO:0030054 cell junction IEA --
GO:0045202 synapse --
GO:0097470 ribbon synapse IEA --
genes like me logo Genes that share ontologies with CTBP2: view

Pathways & Interactions for CTBP2 Gene

genes like me logo Genes that share pathways with CTBP2: view

Pathways by source for CTBP2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for CTBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0008152 metabolic process --
GO:0008285 negative regulation of cell proliferation TAS 9479502
GO:0019079 viral genome replication TAS 9479502
genes like me logo Genes that share ontologies with CTBP2: view

No data available for SIGNOR curated interactions for CTBP2 Gene

Drugs & Compounds for CTBP2 Gene

(2) Drugs for CTBP2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
NADH Nutra 0
genes like me logo Genes that share compounds with CTBP2: view

Transcripts for CTBP2 Gene

Unigene Clusters for CTBP2 Gene

C-terminal binding protein 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTBP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTBP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: -
SP2: -
SP3: -
SP5: - - -
SP6: -

Relevant External Links for CTBP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTBP2 Gene

mRNA expression in normal human tissues for CTBP2 Gene

Protein differential expression in normal tissues from HIPED for CTBP2 Gene

This gene is overexpressed in Retina (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTBP2 Gene

SOURCE GeneReport for Unigene cluster for CTBP2 Gene Hs.501345

mRNA Expression by UniProt/SwissProt for CTBP2 Gene

Tissue specificity: Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas
genes like me logo Genes that share expression patterns with CTBP2: view

Protein tissue co-expression partners for CTBP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CTBP2 Gene

Orthologs for CTBP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTBP2 35
  • 84.47 (n)
  • 85.77 (a)
CTBP2 36
  • 85 (a)
(Canis familiaris)
Mammalia LOC100684514 35
  • 75.81 (n)
  • 70.16 (a)
-- 36
  • 15 (a)
(Mus musculus)
Mammalia Ctbp2 35
  • 84.63 (n)
  • 89.14 (a)
Ctbp2 16
Ctbp2 36
  • 88 (a)
(Pan troglodytes)
Mammalia CTBP2 35
  • 99.15 (n)
  • 99.49 (a)
CTBP2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ctbp2 35
  • 84.29 (n)
  • 88.22 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
(Gallus gallus)
Aves CTBP2 35
  • 85.25 (n)
  • 96.94 (a)
-- 36
  • 78 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctbp2 35
  • 77.69 (n)
  • 90.44 (a)
(Danio rerio)
Actinopterygii -- 35
ctbp2l 35
  • 65.02 (n)
  • 68.35 (a)
CTBP2 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CtBP 37
  • 72 (a)
CtBP 35
  • 66.39 (n)
  • 72.1 (a)
CtBP 36
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003893 35
  • 67.44 (n)
  • 73.7 (a)
(Caenorhabditis elegans)
Secernentea F49E10.5 37
  • 52 (a)
ctbp-1 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SER3 36
  • 24 (a)
SER33 36
  • 24 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9285 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9232 36
  • 63 (a)
Species with no ortholog for CTBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTBP2 Gene

Gene Tree for CTBP2 (if available)
Gene Tree for CTBP2 (if available)

Paralogs for CTBP2 Gene

Paralogs for CTBP2 Gene

(1) SIMAP similar genes for CTBP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTBP2: view

Variants for CTBP2 Gene

Sequence variations from dbSNP and Humsavar for CTBP2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs718947 -- 125,050,580(+) CACAA(A/G)TTCAT intron-variant
rs718948 -- 125,050,769(+) ACTCA(C/T)CATAG intron-variant
rs718949 -- 125,050,460(+) TACGT(A/G)ACGGA intron-variant
rs744451 -- 125,103,796(+) GTGTC(C/T)GGGAA intron-variant
rs750599 -- 125,003,624(-) TGGAG(A/G)CGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTBP2 Gene

Variant ID Type Subtype PubMed ID
nsv896078 CNV Loss 21882294
esv2742750 CNV Deletion 23290073
nsv518907 CNV Loss 19592680
nsv896079 CNV Loss 21882294
dgv836n71 CNV Loss 21882294
esv2742761 CNV Deletion 23290073
esv2773 CNV Deletion 18987735
dgv127e201 CNV Deletion 23290073
dgv128e201 CNV Deletion 23290073
dgv51n21 CNV Loss 19592680
esv2742818 CNV Deletion 23290073
dgv129e201 CNV Deletion 23290073
esv2742840 CNV Deletion 23290073
nsv520770 CNV Gain 19592680
esv2742862 CNV Deletion 23290073
nsv25051 CNV Loss 16902084
nsv7592 CNV Loss 18451855
esv275443 CNV Gain+Loss 21479260
esv998825 CNV Deletion 20482838
nsv7593 CNV Insertion 18451855
esv4147 CNV Deletion 18987735
nsv825606 CNV Gain 20364138
nsv825607 CNV Gain 20364138

Variation tolerance for CTBP2 Gene

Residual Variation Intolerance Score: 86.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 28.00; 99.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTBP2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTBP2 Gene

Disorders for CTBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CTBP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association
Search CTBP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTBP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CTBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTBP2 Gene

Publications for CTBP2 Gene

  1. A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. (PMID: 9479502) Katsanis N. … Fisher E.M.C. (Genomics 1998) 2 23 67
  2. Interaction of ZEB and histone deacetylase with the PLDLS-binding cleft region of monomeric C-terminal binding protein 2. (PMID: 19754958) Zhao L.J. … Chinnadurai G. (BMC Mol. Biol. 2009) 23 67
  3. CtBPs promote cell survival through the maintenance of mitotic fidelity. (PMID: 19506021) Bergman L.M. … Blaydes J.P. (Mol. Cell. Biol. 2009) 23 67
  4. The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cells. (PMID: 19181930) Wang J. … Shannon M.F. (Int. Immunol. 2009) 23 67
  5. Adeno-associated virus serotype-9 efficiently transduces the retinal outer plexiform layer. (PMID: 19626133) Lei B. … Duan D. (Mol. Vis. 2009) 23 67

Products for CTBP2 Gene

Sources for CTBP2 Gene

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