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Aliases for CTBP2 Gene

Aliases for CTBP2 Gene

  • C-Terminal Binding Protein 2 2 3
  • C-Terminal-Binding Protein 2 3
  • Ribeye 3
  • CtBP2 4

External Ids for CTBP2 Gene

Previous GeneCards Identifiers for CTBP2 Gene

  • GC10P058330
  • GC10M125880
  • GC10M126717
  • GC10M126251
  • GC10M126666
  • GC10M120363

Summaries for CTBP2 Gene

Entrez Gene Summary for CTBP2 Gene

  • This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CTBP2 Gene

CTBP2 (C-Terminal Binding Protein 2) is a Protein Coding gene. Among its related pathways are Pathways in cancer and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include transcription corepressor activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is CTBP1.

UniProtKB/Swiss-Prot for CTBP2 Gene

  • Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).

  • Isoform 2 probably acts as a scaffold for specialized synapses

Gene Wiki entry for CTBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTBP2 Gene

Genomics for CTBP2 Gene

Regulatory Elements for CTBP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTBP2 Gene

Start:
124,984,317 bp from pter
End:
125,161,170 bp from pter
Size:
176,854 bases
Orientation:
Minus strand

Genomic View for CTBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTBP2 Gene

Proteins for CTBP2 Gene

  • Protein details for CTBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56545-CTBP2_HUMAN
    Recommended name:
    C-terminal-binding protein 2
    Protein Accession:
    P56545
    Secondary Accessions:
    • A8K2X5
    • D3DRF5
    • O43449
    • Q5SQP7
    • Q69YI3
    • Q86SV0
    • Q9H2T8

    Protein attributes for CTBP2 Gene

    Size:
    445 amino acids
    Molecular mass:
    48945 Da
    Quaternary structure:
    • Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression (By similarity). Interacts with PNN, NRIP1 and WIZ.

    Three dimensional structures from OCA and Proteopedia for CTBP2 Gene

    Alternative splice isoforms for CTBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTBP2 Gene

Proteomics data for CTBP2 Gene at MOPED

Post-translational modifications for CTBP2 Gene

  • Ubiquitination at Lys279
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CTBP2 (CTBP2)

No data available for DME Specific Peptides for CTBP2 Gene

Domains for CTBP2 Gene

Suggested Antigen Peptide Sequences for CTBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56545

UniProtKB/Swiss-Prot:

CTBP2_HUMAN :
  • P56545
Family:
  • Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
genes like me logo Genes that share domains with CTBP2: view

No data available for Gene Families for CTBP2 Gene

Function for CTBP2 Gene

Molecular function for CTBP2 Gene

GENATLAS Biochemistry: C terminal binding phosphoprotein 2,ubiquitously expressed with 2 higher level in heart,skeletal muscle,pancreas,associating to adenovirus E1A,C terminal proteins,involved with histone deacetylase and E2F3 in transcription repression
UniProtKB/Swiss-Prot Function: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).
UniProtKB/Swiss-Prot Function: Isoform 2 probably acts as a scaffold for specialized synapses

Gene Ontology (GO) - Molecular Function for CTBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003713 transcription coactivator activity IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with CTBP2: view
genes like me logo Genes that share phenotypes with CTBP2: view

Animal Model Products

CRISPR Products

miRNA for CTBP2 Gene

miRTarBase miRNAs that target CTBP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTBP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CTBP2 Gene

Localization for CTBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTBP2 Gene

Nucleus. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTBP2 Gene COMPARTMENTS Subcellular localization image for CTBP2 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CTBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0017053 transcriptional repressor complex ISS --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with CTBP2: view

Pathways for CTBP2 Gene

genes like me logo Genes that share pathways with CTBP2: view

Pathways by source for CTBP2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for CTBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0008152 metabolic process --
GO:0008285 negative regulation of cell proliferation TAS 9479502
GO:0019079 viral genome replication TAS 9479502
GO:0035563 positive regulation of chromatin binding IEA --
genes like me logo Genes that share ontologies with CTBP2: view

Compounds for CTBP2 Gene

(2) Novoseek inferred chemical compound relationships for CTBP2 Gene

Compound -log(P) Hits PubMed IDs
nadh 53 3
zinc 39.8 2
genes like me logo Genes that share compounds with CTBP2: view

Transcripts for CTBP2 Gene

Unigene Clusters for CTBP2 Gene

C-terminal binding protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTBP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTBP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: -
SP2: -
SP3: -
SP4:
SP5: - - -
SP6: -
SP7:

Relevant External Links for CTBP2 Gene

GeneLoc Exon Structure for
CTBP2
ECgene alternative splicing isoforms for
CTBP2

Expression for CTBP2 Gene

mRNA expression in normal human tissues for CTBP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTBP2 Gene

SOURCE GeneReport for Unigene cluster for CTBP2 Gene Hs.501345

mRNA Expression by UniProt/SwissProt for CTBP2 Gene

P56545-CTBP2_HUMAN
Tissue specificity: Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas
genes like me logo Genes that share expressions with CTBP2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CTBP2 Gene

Orthologs for CTBP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTBP2 35
  • 99.15 (n)
  • 99.49 (a)
CTBP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTBP2 35
  • 84.47 (n)
  • 85.77 (a)
CTBP2 36
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 15 (a)
ManyToMany
LOC100684514 35
  • 75.81 (n)
  • 70.16 (a)
mouse
(Mus musculus)
Mammalia Ctbp2 35
  • 84.63 (n)
  • 89.14 (a)
Ctbp2 16
Ctbp2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ctbp2 35
  • 84.29 (n)
  • 88.22 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 78 (a)
OneToMany
CTBP2 35
  • 85.25 (n)
  • 96.94 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ctbp2 35
  • 77.69 (n)
  • 90.44 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
CTBP2 36
  • 41 (a)
OneToMany
ctbp2l 35
  • 65.02 (n)
  • 68.35 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003893 35
  • 67.44 (n)
  • 73.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CtBP 35
  • 66.39 (n)
  • 72.1 (a)
CtBP 36
  • 58 (a)
OneToMany
CtBP 37
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea ctbp-1 36
  • 34 (a)
OneToMany
F49E10.5 37
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SER3 36
  • 24 (a)
ManyToMany
SER33 36
  • 24 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9285 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9232 36
  • 63 (a)
OneToMany
Species with no ortholog for CTBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTBP2 Gene

ENSEMBL:
Gene Tree for CTBP2 (if available)
TreeFam:
Gene Tree for CTBP2 (if available)

Paralogs for CTBP2 Gene

Paralogs for CTBP2 Gene

Selected SIMAP similar genes for CTBP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTBP2: view

Variants for CTBP2 Gene

Sequence variations from dbSNP and Humsavar for CTBP2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs27026 -- 124,988,647(-) AGAAC(A/G)CTTCA utr-variant-3-prime
rs718947 -- 125,050,580(+) CACAA(A/G)TTCAT intron-variant
rs718948 -- 125,050,769(+) ACTCA(C/T)CATAG intron-variant
rs718949 -- 125,050,460(+) TACGT(A/G)ACGGA intron-variant
rs744451 -- 125,103,796(+) GTGTC(C/T)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTBP2 Gene

Variant ID Type Subtype PubMed ID
nsv896078 CNV Loss 21882294
esv2742750 CNV Deletion 23290073
nsv518907 CNV Loss 19592680
nsv896079 CNV Loss 21882294
dgv836n71 CNV Loss 21882294
esv2742761 CNV Deletion 23290073
esv2773 CNV Deletion 18987735
dgv127e201 CNV Deletion 23290073
dgv128e201 CNV Deletion 23290073
dgv51n21 CNV Loss 19592680
esv2742818 CNV Deletion 23290073
dgv129e201 CNV Deletion 23290073
esv2742840 CNV Deletion 23290073
nsv520770 CNV Gain 19592680
esv2742862 CNV Deletion 23290073
nsv25051 CNV Loss 16902084
nsv7592 CNV Loss 18451855
esv275443 CNV Gain+Loss 21479260
esv998825 CNV Deletion 20482838
nsv7593 CNV Insertion 18451855
esv4147 CNV Deletion 18987735
nsv825606 CNV Gain 20364138
nsv825607 CNV Gain 20364138

Relevant External Links for CTBP2 Gene

HapMap Linkage Disequilibrium report
CTBP2
Human Gene Mutation Database (HGMD)
CTBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTBP2 Gene

Disorders for CTBP2 Gene

Relevant External Links for CTBP2

Genetic Association Database (GAD)
CTBP2
Human Genome Epidemiology (HuGE) Navigator
CTBP2
genes like me logo Genes that share disorders with CTBP2: view

No data available for UniProtKB/Swiss-Prot for CTBP2 Gene

Publications for CTBP2 Gene

  1. A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. (PMID: 9479502) Katsanis N. … Fisher E.M.C. (Genomics 1998) 2 3 4 23
  2. RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function. (PMID: 11163272) Schmitz F. … Suedhof T.C. (Neuron 2000) 3 4 23
  3. Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition. (PMID: 15060175) Castet A. … Cavailles V. (Nucleic Acids Res. 2004) 3 4 23
  4. Acetylation by p300 regulates nuclear localization and function of the transcriptional corepressor CtBP2. (PMID: 16356938) Zhao L.J. … Chinnadurai G. (J. Biol. Chem. 2006) 3 23
  5. Changes in C-terminal binding protein 2 (CtBP2) corepressor complex induced by E1A and modulation of E1A transcriptional activity by CtBP2. (PMID: 17023432) Zhao L.J. … Chinnadurai G. (J. Biol. Chem. 2006) 3 23

Products for CTBP2 Gene

Sources for CTBP2 Gene

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