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CTBP2 Gene

protein-coding   GIFtS: 64
GCID: GC10M126666

C-Terminal Binding Protein 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
C-Terminal Binding Protein 22 11
C-Terminal-Binding Protein 22
ribeye2
CtBP23

External Ids:    HGNC: 24951   Entrez Gene: 14882   Ensembl: ENSG000001750297   OMIM: 6026195   UniProtKB: P565453   
ORGUL members:         

Export aliases for CTBP2 gene to outside databases

Previous GC identifers: GC10P058330 GC10M125880 GC10M126717 GC10M126251 GC10M120363


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTBP2 Gene:
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional
repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both
proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the
3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci
elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several
transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Feb 2014)

GeneCards Summary for CTBP2 Gene:
CTBP2 (C-terminal binding protein 2) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and transcription corepressor activity. An important paralog of this gene is PHGDH.

UniProtKB/Swiss-Prot: CTBP2_HUMAN, P56545
Function: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT)
differentiation (By similarity)
Function: Isoform 2 probably acts as a scaffold for specialized synapses

Gene Wiki entry for CTBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTBP2 gene promoter:
         AREB6   p300   IRF-7A   Nkx2-5   AP-2alpha   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTBP2 promoter sequence

   Search Chromatin IP Primers for CTBP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.13
Nature(405: 311-319) cytogenetic band:   21q22.11
CTBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTBP2 gene location
GeneLoc information about chromosome 10         GeneLoc Exon Structure

(about GC identifiers)
GC10M126666:   GeneLoc Nature:405,311-319
Start:
126,676,418 bp from pter       18,619,970 bp from centromere
End:
126,849,739 bp from pter 18,650,793 bp from centromere
Size:
173,322 bases 30,824 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AF016507
genomic clones: pS322 pPQ119B8


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CTBP2_HUMAN, P56545 (See protein sequence)
Recommended Name: C-terminal-binding protein 2  
Size: 445 amino acids; 48945 Da
Subunit: Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and
CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific
genes expression (By similarity). Interacts with PNN, NRIP1 and WIZ
1 PDB 3D structure from and Proteopedia for CTBP2:
2OME (3D)    
Secondary accessions: A8K2X5 D3DRF5 O43449 Q5SQP7 Q69YI3 Q86SV0 Q9H2T8
Alternative splicing: 2 isoforms:  P56545-1   P56545-2   (Ref.2 (AAG45951) sequence is in conflict in positions: 455:Y->H, 539:Q->E)

Explore the universe of human proteins at neXtProt for CTBP2: NX_P56545

Explore proteomics data for CTBP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys279
  • Modification sites at PhosphoSitePlus

  • See CTBP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001077383.1  NP_001277143.1  NP_001277144.1  NP_001320.1  NP_073713.2  

    ENSEMBL proteins: 
     ENSP00000338615   ENSP00000311825   ENSP00000357816   ENSP00000434630   ENSP00000436285  
     ENSP00000410474   ENSP00000434424  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR006140 D-isomer_2_OHA_DH_NAD-bd
     IPR006139 D-isomer_2_OHA_DH_cat_dom
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P56545

    ProtoNet protein and cluster: P56545

    1 Blocks protein domain: IPB006139 D-isomer specific 2-hydroxyacid dehydrogenase

    UniProtKB/Swiss-Prot: CTBP2_HUMAN, P56545
    Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family


    Find genes that share domains with CTBP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTBP2_HUMAN, P56545
    Function: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT)
    differentiation (By similarity)
    Function: Isoform 2 probably acts as a scaffold for specialized synapses

         Genatlas biochemistry entry for CTBP2:
    C terminal binding phosphoprotein 2,ubiquitously expressed with 2 higher level in heart,skeletal
    muscle,pancreas,associating to adenovirus E1A,C terminal proteins,involved with histone deacetylase and E2F3 in
    transcription repression

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI16702210
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA--
    GO:0048037cofactor binding ----
    GO:0051287NAD binding IEA--
         
    Find genes that share ontologies with CTBP2           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ctbp2):
     cardiovascular system  embryogenesis  growth/size/body  mortality/aging  muscle 
     nervous system  skeleton 

    Find genes that share phenotypes with CTBP2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CTBP2

    miRNA
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    miRTarBase miRNAs that target CTBP2:
    hsa-let-7b-5p (MIRT051934), hsa-mir-1 (MIRT023997)

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    Selected qRT-PCR Assays for microRNAs that regulate CTBP2 (see all 74):
    hsa-miR-411* hsa-miR-300 hsa-miR-376b hsa-miR-200a hsa-miR-578 hsa-miR-342-3p hsa-miR-3122 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidCTBP2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTBP2_HUMAN, P56545: Nucleus (Potential). Cell junction, synapse (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    cytoskeleton1
    golgi apparatus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0017053transcriptional repressor complex ISS--
    GO:0030054cell junction IEA--
    GO:0045202synapse IEA--

    Find genes that share ontologies with CTBP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTBP2 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Notch Signaling Pathway0.84
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    3Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    4Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway and Pluripotency0.55
    5Chronic myeloid leukemia
    Chronic myeloid leukemia0.42


    Find genes that share SuperPaths with CTBP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CTBP2
        SMAD Signaling Network
    GSK3 Signaling

    4 BioSystems Pathways for CTBP2
        Wnt Signaling Pathway and Pluripotency
    Notch Signaling Pathway
    Neural Crest Differentiation
    Wnt Signaling Pathway NetPath

    1 Sino Biological Pathway for CTBP2
        Notch Signaling Pathway


    4 Kegg Pathways  (Kegg details for CTBP2):
        Wnt signaling pathway
    Notch signaling pathway
    Pathways in cancer
    Chronic myeloid leukemia

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTBP2: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CTBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTBP2 (P565451, 2, 3 ENSP000003118254) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIC1Q145261, 3, ENSP000003140804EBI-741533,EBI-2507362 I2D: score=2 STRING: ENSP00000314080
    ZNF512BQ96KM62, 3MINT-60818 I2D: score=2 
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0008152metabolic process ----
    GO:0008285negative regulation of cell proliferation TAS9479502
    GO:0019079viral genome replication TAS9479502
    GO:0045892negative regulation of transcription, DNA-templated ISS--

    Find genes that share ontologies with CTBP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTBP2

    2 Novoseek inferred chemical compound relationships for CTBP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadh 53 4 15037661 (2), 16762039 (1)
    zinc 39.8 2 10567582 (1), 10801815 (1)



    Find genes that share compounds with CTBP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTBP2 gene (5 alternative transcripts): 
    NM_001083914.1  NM_001290214.1  NM_001290215.1  NM_001329.2  NM_022802.2  

    Unigene Cluster for CTBP2:

    C-terminal binding protein 2
    Hs.501345  [show with all ESTs]
    Unigene Representative Sequence: NM_022802
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337195(uc001lid.4 uc009yak.3 uc009yal.3 uc001lif.4 uc001lih.4)
    ENST00000309035(uc001lie.4) ENST00000334808 ENST00000531469 ENST00000494626
    ENST00000411419 ENST00000395705 ENST00000486955 ENST00000460976 ENST00000493552
    ENST00000476817 ENST00000530884 ENST00000530930 ENST00000467395
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    hsa-miR-411* hsa-miR-300 hsa-miR-376b hsa-miR-200a hsa-miR-578 hsa-miR-342-3p hsa-miR-3122 hsa-miR-629
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    Additional mRNA sequence: 

    AF016507.1 AF222711.1 AK024129.1 AK290390.1 AL833398.1 BC002486.2 BC037900.2 BC047018.1 
    BC052276.1 BC072020.1 BT007012.1 DQ250324.1 

    Selected DOTS entries (see all 30):

    DT.449458  DT.100795066  DT.121277015  DT.100795075  DT.121277044  DT.100795068  DT.100795065  DT.102838708 
    DT.100795069  DT.121277155  DT.121277083  DT.120852815  DT.121276918  DT.121276975  DT.40205746  DT.91708776 
    DT.91762442  DT.100795070  DT.102838706  DT.95189692  DT.100030928  DT.121277124  DT.121433723  DT.91934053 

    Selected AceView cDNA sequences (see all 413):

    AI654311 AA349281 AA371328 AI889573 BQ222947 AA429487 N54705 AA157516 
    AA417287 AA219434 BU628701 AA219546 AA782071 N50048 BQ877029 AA953302 
    AI923347 BM665986 AA629577 BC002486 BM976336 AI424790 AA443709 AA541288 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CTBP2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                                                                -                                       
    SP2:                                                                                -                                       
    SP3:                                                                                -                                       
    SP4:                                                                                                                        
    SP5:        -     -     -                                                                                                   


    ECgene alternative splicing isoforms for CTBP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGGATCA
    CTBP2 Expression
    About this image

    CTBP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTBP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501345

    UniProtKB/Swiss-Prot: CTBP2_HUMAN, P56545
    Tissue specificity: Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTBP2: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTBP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CTBP2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctbp21 , 5 C-terminal binding protein 21, 5 84.63(n)1
    89.14(a)1
      7 (76.32 cM)5
    130171  NM_001170744.11  NP_001164215.11 
     1329875635 
    chicken
    (Gallus gallus)
    Aves CTBP21 C-terminal binding protein 2 85.25(n)
    96.94(a)
      423958  XM_004942344.1  XP_004942401.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    92(a)
    1 → many
    3(62311319-62585910)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ctbp21 C-terminal binding protein 2 77.69(n)
    90.44(a)
      493558  NM_001008195.1  NP_001008196.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB032416.12   -- 80.93(n)   65230  AB032416.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CtBP1 , 3 negative regulation of transcription
    from Pol more3
    C-terminal Binding Protein1
    72(a)3
    66.39(n)1
    72.1(a)1
      87D93
    416021  NM_001275595.11  NP_001262524.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F49E10.53 dehydrogenase 52(a)   X(5898026-5908015)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SER336
    SER36
    3-phosphoglycerate dehydrogenase, catalyzes the fi...
    3-phosphoglycerate dehydrogenase, catalyzes the fi...
    24(a)
    24(a)
    many ↔ many
    many ↔ many
    IX(221081-222490) YIL074C
    V(322686-324095) YER081W


    ENSEMBL Gene Tree for CTBP2 (if available)
    TreeFam Gene Tree for CTBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTBP2 gene
    PHGDH2  CTBP12  ENSG000002128842  
    1 SIMAP similar gene for CTBP2 using alignment to 3 protein entries:     CTBP2_HUMAN (see all proteins):
    CTBP1

    Find genes that share paralogs with CTBP2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for CTBP2 (see all 8)
    PGOHUM00000238591 PGOHUM00000242652 PGOHUM00000235082 PGOHUM00000234295 PGOHUM00000244063


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTBP2 (see all 4561)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1455004261,2
    C--126676521(+) TTTTG-/TTTTTGT 3 -- ut310--------
    rs38326991,2
    C--126676637(-) AAAAA-/ACAAAG 3 -- ut310--------
    rs741609911,2
    C--126676647(+) TTTTTG/TAATTG 3 -- ut311Minor allele frequency- T:0.50WA 2
    rs37405351,2
    C,F,A,H--126676686(-) ATGCCG/ATCCTT 3 -- ut3122Minor allele frequency- A:0.47NA NS EA WA 2484
    rs1444582291,2
    C--126676738(+) ATTAAA/GCTTTT 3 -- ut310--------
    rs70993611,2
    C,F,A--126676837(+) TGCAAC/TTGCCT 3 -- ut3111Minor allele frequency- T:0.18NA WA CSA EA 374
    rs2021272891,2
    C--126676914(+) TTAATA/C/TANNNN 6 -- ut310--------
    rs1163867481,2
    --126676917(+) ATTACA/TTTTTA 3 -- ut310--------
    rs786033251,2
    C--126676964(+) CAATAC/AACAAA 3 -- ut311Minor allele frequency- A:0.00CSA 1
    rs760177681,2
    C--126676987(+) AACTCG/ACACTA 3 -- ut311Minor allele frequency- A:0.00CSA 1

    HapMap Linkage Disequilibrium report for CTBP2 (126676418 - 126849739 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CTBP2 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv998825CNV Deletion20482838
    dgv127e201CNV Deletion23290073
    esv4147CNV Deletion18987735
    esv2742862CNV Deletion23290073
    dgv128e201CNV Deletion23290073
    esv2742761CNV Deletion23290073
    esv2742750CNV Deletion23290073
    dgv129e201CNV Deletion23290073
    esv2742818CNV Deletion23290073
    esv2742840CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTBP2
    DNA2.0 Custom Variant and Variant Library Synthesis for CTBP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602619    OMIM disorders: --


    Find genes that share disorders with CTBP2           About GenesLikeMe

    Genetic Association Database (GAD): CTBP2
    Human Genome Epidemiology (HuGE) Navigator: CTBP2 (25 documents)

    Export disorders for CTBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTBP2 gene, integrated from 10 sources (see all 111):
    (articles sorted by number of sources associating them with CTBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. (PubMed id 9479502)1, 2, 3, 9 Katsanis N. and Fisher E.M.C. (Genomics 1998)
    2. Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition. (PubMed id 15060175)1, 2, 9 Castet A.... Cavailles V. (Nucleic Acids Res. 2004)
    3. RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function. (PubMed id 11163272)1, 2, 9 Schmitz F.... Suedhof T.C. (Neuron 2000)
    4. Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study. (PubMed id 20717903)1, 4 Wang Y....Lange E.M. (Prostate 2011)
    5. Meta-analysis of genome-wide and replication association studies on prostate cancer. (PubMed id 20690139)1, 4 Liu H....Han C. (Prostate 2011)
    6. Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer. (PubMed id 20878950)1, 4 Sun J....Xu J. (Prostate 2011)
    7. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. (PubMed id 20564319)1, 4 Kim S.T....Sun J. (Prostate 2010)
    8. Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. (PubMed id 19902474)1, 4 Hooker S....Kittles R.A. (Prostate 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men. (PubMed id 19866473)1, 4 Zheng S.L....Xu J. (Prostate 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1488 HGNC: 2495 AceView: CTBP2 Ensembl:ENSG00000175029 euGenes: HUgn1488
    ECgene: CTBP2 Kegg: 1488 H-InvDB: CTBP2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CTBP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTBP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CTBP2 gene:
    Search GeneIP for patents involving CTBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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