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Aliases for CTBP2 Gene

Aliases for CTBP2 Gene

  • C-Terminal Binding Protein 2 2 3 5
  • C-Terminal-Binding Protein 2 3
  • Ribeye 3
  • CtBP2 4

External Ids for CTBP2 Gene

Previous GeneCards Identifiers for CTBP2 Gene

  • GC10P058330
  • GC10M125880
  • GC10M126717
  • GC10M126251
  • GC10M126666
  • GC10M120363

Summaries for CTBP2 Gene

Entrez Gene Summary for CTBP2 Gene

  • This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CTBP2 Gene

CTBP2 (C-Terminal Binding Protein 2) is a Protein Coding gene. Diseases associated with CTBP2 include Retinitis Pigmentosa 14 and Prostate Cancer Susceptibility. Among its related pathways are Mesodermal Commitment Pathway and SMAD Signaling Network. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is CTBP1.

UniProtKB/Swiss-Prot for CTBP2 Gene

  • Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).

  • Isoform 2 probably acts as a scaffold for specialized synapses.

Gene Wiki entry for CTBP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTBP2 Gene

Genomics for CTBP2 Gene

Regulatory Elements for CTBP2 Gene

Enhancers for CTBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G125021 1.4 Ensembl ENCODE dbSUPER 8.8 +137.1 137090 4.5 PKNOX1 NFIB KLF17 FEZF1 YY1 ZNF366 SCRT2 KLF7 ZNF263 TSHZ1 ENSG00000226899 CTBP2 EEF1AKMT2 MIR4296 ENSG00000273599
GH10G125146 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.6 +6.7 6674 16.9 PKNOX1 SIN3A FEZF1 YY1 FOS DEK ZNF263 SP3 REST SMARCB1 CTBP2 MIR4296
GH10G125043 1.5 Ensembl ENCODE dbSUPER 7.1 +115.4 115406 3.6 HDGF PKNOX1 ATF1 YY1 KLF7 SP3 ZNF592 ATF4 HNF4A SP7 ENSG00000226899 CTBP2 ZRANB1 MIR4296
GH10G125034 1.4 Ensembl ENCODE dbSUPER 7 +123.9 123878 5.5 TBP PKNOX1 ZSCAN4 ZNF76 FEZF1 ZBTB7B RAD21 RFX5 SCRT2 RCOR1 CTBP2 MIR4296
GH10G125005 1.1 Ensembl ENCODE dbSUPER 8.2 +151.4 151363 7.8 ZNF23 JUND RFX1 FEZF1 REST FOS ENSG00000226899 CTBP2 ENSG00000234134 ENSG00000273599 MIR4296
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CTBP2 on UCSC Golden Path with GeneCards custom track

Promoters for CTBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000034909 1270 4601 SIN3A GLIS2 DEK ZNF263 SP3 REST SMARCB1 ZNF610 GLIS1 WT1

Genomic Location for CTBP2 Gene

124,984,317 bp from pter
125,161,170 bp from pter
176,854 bases
Minus strand

Genomic View for CTBP2 Gene

Genes around CTBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTBP2 Gene

Proteins for CTBP2 Gene

  • Protein details for CTBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-terminal-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K2X5
    • D3DRF5
    • O43449
    • Q5SQP7
    • Q69YI3
    • Q86SV0
    • Q9H2T8

    Protein attributes for CTBP2 Gene

    445 amino acids
    Molecular mass:
    48945 Da
    Quaternary structure:
    • Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression (By similarity). Interacts with PNN, NRIP1 and WIZ. Interacts with human adenovirus 5 E1A protein; this interaction seems to potentiate viral replication (PubMed:23747199). Interacts with MCRIP1 (PubMed:25728771).

    Three dimensional structures from OCA and Proteopedia for CTBP2 Gene

    Alternative splice isoforms for CTBP2 Gene


neXtProt entry for CTBP2 Gene

Post-translational modifications for CTBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CTBP2 (CTBP2)

No data available for DME Specific Peptides for CTBP2 Gene

Domains & Families for CTBP2 Gene

Suggested Antigen Peptide Sequences for CTBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  • Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
genes like me logo Genes that share domains with CTBP2: view

No data available for Gene Families for CTBP2 Gene

Function for CTBP2 Gene

Molecular function for CTBP2 Gene

GENATLAS Biochemistry:
C terminal binding phosphoprotein 2,ubiquitously expressed with 2 higher level in heart,skeletal muscle,pancreas,associating to adenovirus E1A,C terminal proteins,involved with histone deacetylase and E2F3 in transcription repression
UniProtKB/Swiss-Prot Function:
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 2 probably acts as a scaffold for specialized synapses.

Gene Ontology (GO) - Molecular Function for CTBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003713 transcription coactivator activity IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with CTBP2: view
genes like me logo Genes that share phenotypes with CTBP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CTBP2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTBP2 Gene

Localization for CTBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTBP2 Gene

Nucleus. Cell junction, synapse.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTBP2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CTBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0017053 transcriptional repressor complex ISS --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
GO:0097470 ribbon synapse IEA --
genes like me logo Genes that share ontologies with CTBP2: view

Pathways & Interactions for CTBP2 Gene

genes like me logo Genes that share pathways with CTBP2: view

Gene Ontology (GO) - Biological Process for CTBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008152 metabolic process IEA --
GO:0008285 negative regulation of cell proliferation TAS 9479502
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CTBP2: view

No data available for SIGNOR curated interactions for CTBP2 Gene

Drugs & Compounds for CTBP2 Gene

(2) Drugs for CTBP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CTBP2: view

Transcripts for CTBP2 Gene

Unigene Clusters for CTBP2 Gene

C-terminal binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTBP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: -
SP2: -
SP3: -
SP5: - - -
SP6: -

Relevant External Links for CTBP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTBP2 Gene

Protein differential expression in normal tissues from HIPED for CTBP2 Gene

This gene is overexpressed in Retina (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTBP2 Gene

Protein tissue co-expression partners for CTBP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTBP2 Gene:


SOURCE GeneReport for Unigene cluster for CTBP2 Gene:


mRNA Expression by UniProt/SwissProt for CTBP2 Gene:

Tissue specificity: Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.

Evidence on tissue expression from TISSUES for CTBP2 Gene

  • Nervous system(4.7)
  • Intestine(4.5)
  • Kidney(4.5)
  • Pancreas(4.4)
  • Blood(4.3)
  • Liver(4.3)
  • Eye(2.9)
  • Lung(2.7)
  • Muscle(2.6)
  • Skin(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CTBP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTBP2 Gene

Orthologs for CTBP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTBP2 34 35
  • 99.15 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 95 (a)
(Mus musculus)
Mammalia Ctbp2 34 16 35
  • 84.63 (n)
(Bos Taurus)
Mammalia CTBP2 34 35
  • 84.47 (n)
(Rattus norvegicus)
Mammalia Ctbp2 34
  • 84.29 (n)
(Canis familiaris)
Mammalia LOC100684514 34
  • 75.81 (n)
-- 35
  • 15 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
(Gallus gallus)
Aves CTBP2 34
  • 85.25 (n)
-- 35
  • 78 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctbp2 34
  • 77.69 (n)
(Danio rerio)
Actinopterygii ctbp2l 34
  • 65.02 (n)
CTBP2 35
  • 41 (a)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003893 34
  • 67.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta CtBP 36 34 35
  • 66.39 (n)
(Caenorhabditis elegans)
Secernentea F49E10.5 36
  • 52 (a)
ctbp-1 35
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SER3 35
  • 24 (a)
SER33 35
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9232 35
  • 63 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9285 34
Species where no ortholog for CTBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTBP2 Gene

Gene Tree for CTBP2 (if available)
Gene Tree for CTBP2 (if available)

Paralogs for CTBP2 Gene

Paralogs for CTBP2 Gene

(1) SIMAP similar genes for CTBP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTBP2: view

Variants for CTBP2 Gene

Sequence variations from dbSNP and Humsavar for CTBP2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000038151 -- 125,057,465(+) TGACT(C/G)GCAAT intron-variant
rs1000093476 -- 125,109,331(+) TCCAA(C/T)TGGAA intron-variant
rs1000099236 -- 125,024,687(+) AAGCC(C/T)GGCCA intron-variant
rs1000103745 -- 124,993,841(+) CGGCT(A/G)GGGCA intron-variant
rs1000115541 -- 125,161,364(+) ATCCT(C/T)CTCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CTBP2 Gene

Variant ID Type Subtype PubMed ID
dgv519e59 CNV duplication 20981092
dgv51n21 CNV loss 19592680
esv275443 CNV gain+loss 21479260
esv2773 CNV loss 18987735
esv3624823 CNV loss 21293372
esv4147 CNV loss 18987735
esv998825 CNV deletion 20482838
nsv1069088 CNV deletion 25765185
nsv1112598 CNV deletion 24896259
nsv25051 CNV deletion 16902084
nsv478178 CNV novel sequence insertion 20440878
nsv518907 CNV loss 19592680
nsv520770 CNV gain 19592680
nsv552289 CNV loss 21841781
nsv7592 CNV deletion 18451855
nsv7593 CNV insertion 18451855
nsv825606 CNV gain 20364138
nsv825607 CNV gain 20364138
nsv948218 CNV duplication 23825009
nsv948219 CNV duplication 23825009
nsv948220 CNV duplication 23825009
nsv948221 CNV duplication 23825009
nsv951869 CNV deletion 24416366

Variation tolerance for CTBP2 Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 28.00; 99.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTBP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTBP2 Gene

Disorders for CTBP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CTBP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 14
  • rp14
prostate cancer susceptibility
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards
Search CTBP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTBP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CTBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTBP2 Gene

Publications for CTBP2 Gene

  1. A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. (PMID: 9479502) Katsanis N. … Fisher E.M.C. (Genomics 1998) 2 3 4 22 64
  2. Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition. (PMID: 15060175) Castet A. … Cavailles V. (Nucleic Acids Res. 2004) 3 4 22 64
  3. RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function. (PMID: 11163272) Schmitz F. … Suedhof T.C. (Neuron 2000) 3 4 22 64
  4. MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP. (PMID: 25728771) Ichikawa K. … Takekawa M. (Mol. Cell 2015) 3 4 64
  5. Meta-analysis of genome-wide and replication association studies on prostate cancer. (PMID: 20690139) Liu H. … Han C. (Prostate 2011) 3 46 64

Products for CTBP2 Gene

Sources for CTBP2 Gene

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