CTBP1 Gene
protein-coding GIFtS: 69
GCID: GC04M001205
|
|
C-terminal binding protein 1
| |
Aliases
for CTBP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| C-Terminal Binding Protein 11 2 | | CtBP13 | | BARS1 2 | | EC 1.1.1.-3 | | Brefeldin A-Ribosylated Substrate2 | | EC 1.1.18 | | C-Terminal-Binding Protein 12 | | EC 1.1.1.1588 | | CTBP3 | | |
Export aliases for CTBP1 gene to outside databasesPrevious GC identifers: GC04M001211 GC04M001195 GC04M001158 GC04M001173 |
Summaries
for CTBP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CTBP1:
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is atranscriptional repressor and may play a role during cellular proliferation. This protein and the product of a secondclosely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex whichparticipates in regulation of gene expression during development. Alternative splicing of transcripts from this generesults in multiple transcript variants. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CTBP1_HUMAN, Q13363Function: Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex.Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators suchas GLIS2. Has dehydrogenase activity
Gene Wiki entry for CTBP1
|
Genomic Views
for CTBP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_037622.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CTBP1 gene promoter:
Egr-1 p300 MIF-1 Nkx2-5 Nkx5-1 Meis-1b AREB6 Meis-1a ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for CTBP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTBP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16CTBP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M001205: view genomic region
(about GC identifiers)
Start:
|
1,205,228 bp from pter |
End:
|
1,243,741 bp from pter |
Size:
|
38,514 bases |
Orientation:
|
minus strand |
|
Proteins
for CTBP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CTBP1_HUMAN, Q13363 (See
protein sequence)Recommended Name: C-terminal-binding protein 1 Size: 440 amino acids; 47535 Da
Cofactor: NAD. Required for efficient interaction with E1A. Cofactor binding induces a conformation change
Subunit: Homo- or heterodimer. Heterodimer with CTBP2. Interacts with PRDM16; the interaction represses white adiposetissue (WAT)-specific genes expression. Interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 and ZNF217 (By similarity).Interacts with adenovirus E1A protein (via its C-terminus); the interaction disrupts the interaction of CTBP1 withRBBP8. Interacts with Epstein-Barr virus EBNA3 and EBNA6. Interacts with ELK3 (via its PXDLS motif). Interacts withRBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with FOXP1, HIPK2,PNN, NRIP1, MECOM, ZNF366, ZFHX1B and WIZ. Interaction with SATB1 (non-acetylated form); the interaction stabilizesits attachment to DNA and promotes transcription repression
Subcellular location: Cytoplasm. Nucleus
1 PDB 3D structure from  and Proteopedia  for CTBP1:1MX3 (3D)
Secondary accessions: Q4W5N3 Q7Z2Q5Alternative splicing: 2 isoforms: Q13363-1 Q13363-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CTBP1: NX_Q13363
Post-translational modifications:
The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 inducesproteasomal degradation1
ADP-ribosylated; when cells are exposed to brefeldin A (By similarity)1
Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX41
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13363
4/5 DME Specific Peptides for CTBP1 (Q13363) (see all 5)
CTBP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001012632.1 NP_001319.1
ENSEMBL proteins: ENSP00000372411 ENSP00000290921 ENSP00000422148 ENSP00000422364 ENSP00000424575 ENSP00000424684 ENSP00000422730 ENSP00000426470 ENSP00000425053 ENSP00000420983 ENSP00000423872
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
CTBP1 for ontologies About GeneDecksing
CTBP1 Antibody Products:
Assay Products for CTBP1: |
Protein
Domains /
Families
for CTBP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CTBP1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13363ProtoNet protein and cluster: Q13363 1 Blocks protein family: IPB006139 D-isomer specific 2-hydroxyacid dehydrogenase
UniProtKB/Swiss-Prot: CTBP1_HUMAN, Q13363Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family |
Function
for CTBP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CTBP1_HUMAN, Q13363Function: Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex.Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators suchas GLIS2. Has dehydrogenase activity Genatlas biochemistry entry for CTBP1:C terminal binding protein 1,48kDa
Enzyme Numbers (IUBMB): EC 1.1.1.1582 EC 1.1.12 EC 1.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTBP1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTBP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CTBP1 (NM_001328) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTBP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTBP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTBP1 |
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table
CTBP1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CTBP1:
Animal Models:
Mouse knock-out Ctbp1tm1Sor for CTBP1
7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ctbp1):
CTBP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CTBP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Wnt Signaling Pathway | | | 2 | Development_Ligand-dependent activation of the ESR1/AP-1 pathway | | | 3 | Notch Signaling Pathway | | | 4 | Glucose / Energy Metabolism | | | 5 | SMAD Signaling Network | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CTBP1
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CTBP1
2 
Cell Signaling Technology (CST) Pathways for CTBP1
1  GeneGo (Thomson Reuters) Pathway for CTBP1
5/9  BioSystems Pathways for CTBP1 (see all 9)
4 
Kegg Pathways (Kegg details for CTBP1):
CTBP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTBP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/147 Interacting proteins for CTBP1 (Q133631, 2, 3 ENSP000002909214) via UniProtKB, MINT, STRING, and/or I2D (see all 147)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TGIF1 | Q155832, 3, ENSP000003279594 | MINT-14492 MINT-14493 I2D:
score=4 STRING: ENSP00000327959 | | ZEB1 | P372752, 3, ENSP000003192484 | MINT-17555 I2D:
score=6 STRING: ENSP00000319248 | | CHD3 | Q128732, 3, ENSP000003697164 | MINT-8253847 I2D:
score=2 STRING: ENSP00000369716 | | CTNNA1 | P352212, 3, ENSP000003046694 | MINT-8253858 I2D:
score=2 STRING: ENSP00000304669 | | HIC1 | Q145261, 3, ENSP000003140804 | EBI-908846,EBI-2507362 I2D:
score=2 STRING: ENSP00000314080 |
About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
CTBP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CTBP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CTBP1 for compounds About GeneDecksing
 Browse Tocris compounds for CTBP1
1 HMDB Compound for CTBP1 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| NAD | 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28) | 53-84-9 | -- |
2 DrugBank Compounds for CTBP1 About this table
7 Novoseek chemical compound relationships for CTBP1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nadh |
60.5 |
35 |
11847309 (3), 12872005 (3), 17508915 (2), 18184656 (2) (see all 17) |
| nad+ |
52.1 |
15 |
12872005 (4), 12606049 (3), 11847309 (2), 12419229 (2) (see all 8) |
| zinc |
47.3 |
6 |
20175752 (1), 12556451 (1), 10567582 (1), 16940172 (1) (see all 5) |
| lysine |
30.7 |
8 |
16919702 (3), 12679040 (1), 12161448 (1), 16122695 (1) |
| pyruvate |
3.46 |
2 |
8416925 (1), 17157814 (1) |
| oxygen |
0 |
1 |
18676825 (1) |
| retinoic acid |
0 |
2 |
17028196 (2) |
Search CenterWatch for drugs/clinical trials and news about CTBP1
|
Transcripts
for CTBP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CTBP1 gene (2 alternative transcripts): NM_001012614.1 NM_001328.2 Unigene Cluster for CTBP1: C-terminal binding protein 1 Hs.208597 [show with all ESTs]Unigene Representative Sequence: BC06433318 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000382952(uc003gcu.1) ENST00000290921(uc003gcv.1 uc003gcw.3)
ENST00000503594 ENST00000514596 ENST00000504092 ENST00000382950 ENST00000510739
ENST00000511907 ENST00000505826 ENST00000514669 ENST00000506180 ENST00000504784
ENST00000514210 ENST00000514495 ENST00000515399 ENST00000513420 ENST00000510568(uc003gcx.1)
ENST00000515690
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTBP1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTBP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CTBP1 (NM_001328) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTBP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTBP1 |
Additional cDNA sequence: AF091555.1 BC011655.2 BC053320.1 BC064333.1 BC072021.1 BC098400.1 U37408.1 24/29 DOTS entries (see all 29): DT.95120753 DT.91766289 DT.119174 DT.100662472 DT.121643846 DT.100702132 DT.100830096 DT.100821782 DT.100821778 DT.100821786 DT.100642999 DT.100037745 DT.100728975 DT.100857972 DT.121228061 DT.100808505 DT.100821779 DT.100821781 DT.100821783 DT.121228064 DT.95349696 DT.97762053 DT.100663982 DT.100692411 24/397 AceView cDNA sequences (see all 397): AU117448 BQ018373 AI351337 BM851622 AI766365 BM712795 BU180468 AI301641 CD671503 AA377050 BI836308 BQ897865 AI362845 BF434044 N22109 BX108706 BM763348 CA413495 AI308150 BF221764 BX394032 BM918472 BQ420441 AI168198
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for CTBP1 (see all 16) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | |
| ExUns: | 15b | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · | 18c |
|---|
|
| SP1: | - | | | | | | | | | | | | |
| SP2: | - | | | | | | | | | | | | |
| SP3: | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CTBP1
|
Expression
for CTBP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CTBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGTGACTG
About this image
See CTBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTBP1
SOURCE GeneReport for Unigene cluster: Hs.208597
SABiosciences Expression via Pathway-Focused PCR Arrays including CTBP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTBP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTBP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTBP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTBP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTBP1 |
Orthologs
for CTBP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for CTBP1 gene from 9/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CTBP11 |
C-terminal binding protein 1 |
79.16(n)
96.49(a) |
|
422904 NM_001012890.1 NP_001012908.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CTBP16 |
-- |
94(a) |
1 ↔ 1 |
GL343447.1(523031-546086) |
African clawed frog
(Xenopus laevis) |
Amphibia |
ctbp1-A2 |
C-terminal binding protein 1 |
78.46(n) |
|
AF091554.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ctbp12 |
C-terminal binding protein 1 |
76.5(n) |
|
65229 AB032415.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CtBP3 |
negative regulation of transcription from
Pol more |
72(a) |
|
87D9 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
F49E10.53
ctbp-11 |
dehydrogenase3
Protein CTBP-11 |
53(a)3
53.09(n)1
53.37(a)1 |
|
X(5898026-5908015)3
1808531 NM_076582.31 NP_508983.21 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G721906 |
D-isomer specific 2-hydroxyacid dehydrogenase-like... |
18(a) |
1 → many |
1(27167363-27169717) |
rice
(Oryza sativa) |
Liliopsida |
---- |
erythronate-4-phosphate dehydrogenase domain conta...erythronate-4-phosphate dehydrogenase domain conta... |
16(a)16(a) |
many ↔ manymany ↔ many |
7(9296739-9299506) 7(9352047-9356795) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
ghrA6 |
glyoxylate/hydroxypyruvate reductase A |
19(a) |
possible ortholog |
Chromosome(1097109-1098047) |
ENSEMBL Gene Tree for CTBP1 (if available)
TreeFam Gene Tree for CTBP1 (if available) |
Paralogs
for CTBP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CTBP1 gene
- PHGDH2 CTBP22 ENSG000002128842
2 SIMAP similar genes for CTBP1 using alignment to 12 protein entries: CTBP1_HUMAN (see all proteins):DKFZp434B0914 CTBP2
CTBP1 for paralogs About GeneDecksing
|
Genomic Variants
for CTBP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CTBP1
3 CNVs: 68601 53617 68602 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTBP1 |
|
Disorders
/ Diseases
for CTBP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CTBP1 for disorders About GeneDecksing
OMIM gene information: 602618
OMIM disorders: --
19  diseases for CTBP1: About MalaCardsfamilial adenomatous polyposis adenomatous polyposis coli polyposis chronic myeloid leukemia
myeloid leukemia holoprosencephaly lymphopenia colon carcinoma
colorectal cancer nephropathy hepatitis b breast cancer
leukemia melanoma carcinoma adenoma
hepatitis hypoxia neuronitis
10 Novoseek disease relationships for CTBP1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| familial adenomatous polyposis |
36 |
3 |
17028196 (2) |
| colon cancer |
31.6 |
1 |
19798104 (1) |
| colorectal cancer |
13.7 |
7 |
16547505 (3), 17028196 (1), 16510874 (1), 20383323 (1) |
| tumors |
12.9 |
15 |
16740659 (3), 16804902 (3), 18086895 (2), 15831459 (1) (see all 9) |
| cancer |
10.5 |
8 |
17662696 (2), 16547590 (1), 20372804 (1), 16740659 (1) (see all 7) |
| colon carcinoma |
2.09 |
3 |
16804902 (2), 15831101 (1) |
| breast cancer |
1.78 |
3 |
19744932 (1) |
| carcinoma |
0 |
2 |
19450512 (2) |
| lymphoma |
0 |
1 |
18212045 (1) |
| melanoma |
0 |
23 |
19216735 (7), 12384563 (3), 14702186 (1) |
Human Genome Epidemiology (HuGE) Navigator: CTBP1 (4 documents)
Export disorders for CTBP1 gene to outside databases
|
Publications
for CTBP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CTBP1 gene, integrated from 9 sources (see all 225):
(articles sorted by number of sources associating them with CTBP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate polycomb proteins. (PubMed id 9858600)1, 2, 9 Sewalt R.G.A.B....Otte A.P. (1999)
- Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1. (PubMed id 19103759)1, 2, 9 Purbey P.K.... Galande S. (2009)
- Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP. (PubMed id 11509661)1, 2, 9 Vo N.... Goodman R.H. (2001)
- The polycomb protein Pc2 is a SUMO E3. (PubMed id 12679040)1, 2, 9 Kagey M.H.... Wotton D. (2003)
- Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase. (PubMed id 12419229)1, 2, 9 Kumar V.... Aggarwal A.K. (2002)
- Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. (PubMed id 15542832)1, 2, 9 Alpatov R.... Sugrue S.P. (2004)
- A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. (PubMed id 9479502)1, 3, 9 Katsanis N. and Fisher E.M.C. (1998)
- A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. (PubMed id 8440238)1, 2, 9 Boyd J.M....Chinnadurai G. (1993)
- Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. (PubMed id 16061479)1, 2, 9 Long J.... Park M. (2005)
- Interaction of EVI1 with cAMP-responsive element-binding protein- binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles. (PubMed id 11568182)1, 2, 9 Chakraborty S.... Nucifora G. (2001)
|
External Searches for CTBP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CTBP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CTBP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CTBP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CTBP1 gene:
Search GeneIP for patents involving CTBP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CTBP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CTBP1 | | OriGene shRNA RFP for CTBP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTBP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTBP1 | | | OriGene Protein Over-expression Lysate for CTBP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CTBP1 | | OriGene 3'-UTR Clone for CTBP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTBP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTBP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CTBP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for CTBP1 |
| |  |  |  |  | | | | | | Recombinant Protein for CTBP1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTBP1 |
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