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Aliases for CTBP1 Gene

Aliases for CTBP1 Gene

  • C-Terminal Binding Protein 1 2 3 5
  • Brefeldin A-Ribosylated Substrate 2 3
  • C-Terminal-Binding Protein 1 3
  • EC 1.1.1.158 61
  • EC 1.1.1.- 4
  • EC 1.1.1 61
  • CtBP1 4
  • BARS 3
  • CTBP 4

External Ids for CTBP1 Gene

Previous GeneCards Identifiers for CTBP1 Gene

  • GC04M001195
  • GC04M001158
  • GC04M001205
  • GC04M001173

Summaries for CTBP1 Gene

Entrez Gene Summary for CTBP1 Gene

  • This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTBP1 Gene

CTBP1 (C-Terminal Binding Protein 1) is a Protein Coding gene. Diseases associated with CTBP1 include Colon Adenoma and Borna Disease. Among its related pathways are Notch signaling pathway (KEGG) and Signaling by Wnt. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is CTBP2.

UniProtKB/Swiss-Prot for CTBP1 Gene

  • Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.

Gene Wiki entry for CTBP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTBP1 Gene

Genomics for CTBP1 Gene

Regulatory Elements for CTBP1 Gene

Enhancers for CTBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G001197 1.6 Ensembl ENCODE dbSUPER 12.6 +45.6 45599 13.8 HDGF PKNOX1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 FOS SP5 CRIPAK CTBP1-AS2 UVSSA CTBP1 MAEA RNF212 ENSG00000273179 SPON2 LOC100130872 LOC101928548
GH04G001344 1.7 FANTOM5 ENCODE dbSUPER 11.5 -96.6 -96643 4.3 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A YY1 ZNF143 ZNF207 CRIPAK UVSSA MAEA CTBP1-AS2 CTBP1 MFSD7 GC04M001342 ENSG00000254094
GH04G001170 1.5 Ensembl ENCODE dbSUPER 12 +77.7 77685 3.8 HNRNPUL1 HDGF FOXA2 PKNOX1 SIN3A ZNF2 CBX5 ZNF143 ZNF207 KLF13 UVSSA SPON2 ENSG00000251188 CTBP1-AS2 CTBP1 MAEA ZNF732 CRIPAK ENSG00000273179 ENSG00000251639
GH04G001212 1.4 Ensembl ENCODE dbSUPER 12.1 +34.2 34217 8.0 HDGF PKNOX1 TBL1XR1 BMI1 RAD21 ZEB1 EGR1 SCRT2 ZNF207 RELB CTBP1-AS2 CRIPAK UVSSA MAEA CTBP1 RNF212 LOC105374344 CTBP1-AS
GH04G001191 1.4 Ensembl ENCODE dbSUPER 12.1 +56.5 56488 5.0 PKNOX1 RAD21 YY1 GLIS2 CBX5 ZNF207 FOS USF2 REST TBX21 CTBP1-AS2 CRIPAK UVSSA CTBP1 MAEA RNF212 SLC26A1 FGFRL1 LOC101928548 ENSG00000273179
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CTBP1 on UCSC Golden Path with GeneCards custom track

Promoters for CTBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164799 1548 2601 HDGF ATF1 ARNT CREB3L1 ZFP64 SIN3A YY1 ZNF766 GLIS2 ELK1

Genomic Location for CTBP1 Gene

Chromosome:
4
Start:
1,211,440 bp from pter
End:
1,250,248 bp from pter
Size:
38,809 bases
Orientation:
Minus strand

Genomic View for CTBP1 Gene

Genes around CTBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTBP1 Gene

Proteins for CTBP1 Gene

  • Protein details for CTBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13363-CTBP1_HUMAN
    Recommended name:
    C-terminal-binding protein 1
    Protein Accession:
    Q13363
    Secondary Accessions:
    • Q4W5N3
    • Q7Z2Q5

    Protein attributes for CTBP1 Gene

    Size:
    440 amino acids
    Molecular mass:
    47535 Da
    Cofactor:
    Name=NAD(+); Xref=ChEBI:CHEBI:57540;
    Quaternary structure:
    • Homo- or heterodimer. Heterodimer with CTBP2. Interacts with PRDM16; the interaction represses white adipose tissue (WAT)-specific genes expression. Interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 and ZNF217. Interacts with adenovirus E1A protein (via its C-terminus); the interaction disrupts the interaction of CTBP1 with RBBP8. Interacts with Epstein-Barr virus EBNA3 and EBNA6. Interacts with ELK3 (via its PXDLS motif). Interacts with RBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with FOXP1, HIPK2, PNN, NRIP1, MECOM, ZNF366, ZFHX1B and WIZ. Interaction with SATB1 (non-acetylated form); the interaction stabilizes its attachment to DNA and promotes transcription repression. Interacts with BCL6; the interaction is required for BCL6 transcriptional autoinhibition and inhibition of some BCL6 target genes. Interacts with IKZF4 (By similarity). Interacts with human adenovirus 5 E1A protein; this interaction seems to potentiate viral replication (PubMed:23747199). Interacts with MCRIP1 (unphosphorylated form, via the PXDLS motif); competitively inhibiting CTBP-ZEB1 interaction (PubMed:25728771).

    Three dimensional structures from OCA and Proteopedia for CTBP1 Gene

    Alternative splice isoforms for CTBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTBP1 Gene

Selected DME Specific Peptides for CTBP1 Gene

Q13363:
  • ITLTREDL
  • KQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVH
  • PAAVEGIVPSAMSLSH
  • VAHPPHAPSPGQT
  • QGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAIT

Post-translational modifications for CTBP1 Gene

  • ADP-ribosylated; when cells are exposed to brefeldin A.
  • Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.
  • The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.
  • Ubiquitination at Lys194
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CTBP1 (CTBP1)
  • Cloud-Clone Corp. Antibodies for CTBP1

Domains & Families for CTBP1 Gene

Suggested Antigen Peptide Sequences for CTBP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13363

UniProtKB/Swiss-Prot:

CTBP1_HUMAN :
  • Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Family:
  • Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
genes like me logo Genes that share domains with CTBP1: view

No data available for Gene Families for CTBP1 Gene

Function for CTBP1 Gene

Molecular function for CTBP1 Gene

GENATLAS Biochemistry:
C terminal binding protein 1,48kDa
UniProtKB/Swiss-Prot Function:
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.

Enzyme Numbers (IUBMB) for CTBP1 Gene

Gene Ontology (GO) - Molecular Function for CTBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IDA 16287852
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 11568182
GO:0008022 protein C-terminus binding TAS 8440238
GO:0008134 transcription factor binding IPI 16609867
genes like me logo Genes that share ontologies with CTBP1: view
genes like me logo Genes that share phenotypes with CTBP1: view

Human Phenotype Ontology for CTBP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CTBP1 Gene

MGI Knock Outs for CTBP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for CTBP1 Gene

Localization for CTBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTBP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTBP1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
golgi apparatus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for CTBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS,IDA --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IEA --
GO:0017053 transcriptional repressor complex IDA,ISS --
genes like me logo Genes that share ontologies with CTBP1: view

Pathways & Interactions for CTBP1 Gene

genes like me logo Genes that share pathways with CTBP1: view

SIGNOR curated interactions for CTBP1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CTBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19162039
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation TAS 8440238
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CTBP1: view

Drugs & Compounds for CTBP1 Gene

(7) Drugs for CTBP1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Formic acid Experimental Pharma Target 0
NAD Pharma Full agonist, Agonist 0

(2) Additional Compounds for CTBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTBP1: view

Transcripts for CTBP1 Gene

Unigene Clusters for CTBP1 Gene

C-terminal binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTBP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - - - -
SP8: - - - - - - - - - - - - - - - - - -
SP9: -
SP10: - - - - - - - - -
SP11: - - - - - -
SP12:
SP13: -
SP14: - - - - - - - - - - - -
SP15: - - - - - - - - -
SP16:

ExUns: 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for CTBP1 Gene

GeneLoc Exon Structure for
CTBP1
ECgene alternative splicing isoforms for
CTBP1

Expression for CTBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTBP1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTBP1 Gene



Protein tissue co-expression partners for CTBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTBP1 Gene:

CTBP1

SOURCE GeneReport for Unigene cluster for CTBP1 Gene:

Hs.208597

mRNA Expression by UniProt/SwissProt for CTBP1 Gene:

Q13363-CTBP1_HUMAN
Tissue specificity: Expressed in germinal center B-cells.

Evidence on tissue expression from TISSUES for CTBP1 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Lung(4.4)
  • Kidney(2.5)
  • Eye(2.4)
  • Intestine(2.3)
  • Skin(2.1)
  • Blood(2)
  • Heart(2)
  • Muscle(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with CTBP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTBP1 Gene

Orthologs for CTBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTBP1 34 35
  • 98.67 (n)
oppossum
(Monodelphis domestica)
Mammalia CTBP1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTBP1 35
  • 95 (a)
OneToOne
LOC612240 34
  • 89.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CTBP1 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTBP1 34 35
  • 90.48 (n)
mouse
(Mus musculus)
Mammalia Ctbp1 34 16 35
  • 88.56 (n)
rat
(Rattus norvegicus)
Mammalia Ctbp1 34
  • 88.52 (n)
chicken
(Gallus gallus)
Aves CTBP1 34 35
  • 79.16 (n)
lizard
(Anolis carolinensis)
Reptilia CTBP1 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctbp1 34
  • 78.71 (n)
African clawed frog
(Xenopus laevis)
Amphibia ctbp1-A 34
zebrafish
(Danio rerio)
Actinopterygii CTBP1 35
  • 91 (a)
OneToOne
zgc:136929 34
  • 79.04 (n)
ctbp1 34
fruit fly
(Drosophila melanogaster)
Insecta CtBP 36 35
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea ctbp-1 34 35
  • 53.09 (n)
F49E10.5 36
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SER3 35
  • 20 (a)
ManyToMany
SER33 35
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9232 35
  • 63 (a)
OneToMany
Species where no ortholog for CTBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTBP1 Gene

ENSEMBL:
Gene Tree for CTBP1 (if available)
TreeFam:
Gene Tree for CTBP1 (if available)

Paralogs for CTBP1 Gene

Paralogs for CTBP1 Gene

genes like me logo Genes that share paralogs with CTBP1: view

Variants for CTBP1 Gene

Sequence variations from dbSNP and Humsavar for CTBP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs869320802 Pathogenic 1,213,028(-) CAGGC(C/T)GGATC intron-variant, reference, missense
rs1000002227 -- 1,229,655(+) GGAGC(G/T)GACCC intron-variant
rs1000012449 -- 1,245,257(+) TGTGA(A/T)CAAAG intron-variant, utr-variant-5-prime
rs1000076552 -- 1,219,318(+) CCACA(C/T)TCCAG intron-variant
rs1000085722 -- 1,245,520(+) CCCAG(A/G)AGCCC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CTBP1 Gene

Variant ID Type Subtype PubMed ID
dgv2704n106 CNV deletion 24896259
dgv2912e59 CNV duplication 20981092
dgv636n27 CNV loss 19166990
dgv8890n54 CNV loss 21841781
dgv8891n54 CNV loss 21841781
dgv8892n54 CNV loss 21841781
dgv8893n54 CNV gain 21841781
dgv8894n54 CNV loss 21841781
esv1540743 CNV insertion 17803354
esv1720969 CNV insertion 17803354
esv24472 CNV gain 19812545
esv2726769 CNV deletion 23290073
esv27609 CNV loss 19812545
esv3569245 CNV loss 25503493
esv3569246 CNV loss 25503493
nsv478768 CNV novel sequence insertion 20440878
nsv508988 CNV insertion 20534489
nsv593278 CNV loss 21841781
nsv593281 CNV loss 21841781
nsv593282 CNV gain 21841781
nsv593286 CNV gain 21841781
nsv593287 CNV gain 21841781
nsv593290 CNV loss 21841781
nsv593291 CNV gain+loss 21841781
nsv593293 CNV loss 21841781
nsv822425 CNV loss 20364138
nsv822430 CNV loss 20364138
nsv822432 CNV gain 20364138
nsv822433 CNV gain 20364138
nsv829835 CNV gain 17160897
nsv950331 CNV deletion 24416366

Variation tolerance for CTBP1 Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTBP1 Gene

Human Gene Mutation Database (HGMD)
CTBP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTBP1 Gene

Disorders for CTBP1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CTBP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colon adenoma
  • adenomatous polyp of colon
borna disease
  • enzootic encephalomyelitis
wolf-hirschhorn syndrome
  • 4p deletion syndrome
alzheimer disease 12
  • alzheimer's disease 12
- elite association - COSMIC cancer census association via MalaCards
Search CTBP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTBP1

Genetic Association Database (GAD)
CTBP1
Human Genome Epidemiology (HuGE) Navigator
CTBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTBP1
genes like me logo Genes that share disorders with CTBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTBP1 Gene

Publications for CTBP1 Gene

  1. Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1. (PMID: 19103759) Purbey P.K. … Galande S. (Mol. Cell. Biol. 2009) 3 4 22 64
  2. CtBP is an essential corepressor for BCL6 autoregulation. (PMID: 18212045) Mendez L.M. … Ye B.H. (Mol. Cell. Biol. 2008) 3 4 22 64
  3. Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. (PMID: 15542832) Alpatov R. … Sugrue S.P. (Mol. Cell. Biol. 2004) 3 4 22 64
  4. The polycomb protein Pc2 is a SUMO E3. (PMID: 12679040) Kagey M.H. … Wotton D. (Cell 2003) 3 4 22 64
  5. Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase. (PMID: 12419229) Kumar V. … Aggarwal A.K. (Mol. Cell 2002) 3 4 22 64

Products for CTBP1 Gene

Sources for CTBP1 Gene

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