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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTAGE6 Gene

protein-coding   GIFtS: 31
GCID: GC07M143459

CTAGE Family, Member 6

(Previous names: CTAGE family, member 6, pseudogene)
(Previous symbol: CTAGE6P)
  Search for CTAGE6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CTAGE Family, Member 61 2     CTAGE Family Member 62
CTAGE6P1 2 3     Cutaneous T-Cell Lymphoma-Associated Antigen 62
CTAGE Family, Member 6, Pseudogene1 2     Putative Protein CTAGE-62
Protein CTAGE-62 3     

External Ids:    HGNC: 286441   Entrez Gene: 3403072   Ensembl: ENSG000002713217   UniProtKB: Q86UF23   

Export aliases for CTAGE6 gene to outside databases

Previous GC identifers: GC07M142844 GC07M142889 GC07M143083 GC07M143453 GC07M143455


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CTAGE6 Gene: 
CTAGE6 (CTAGE family, member 6) is a protein-coding gene. An important paralog of this gene is CTAGE4.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTAGE6 gene promoter:
         LHX3b/Lhx3b   Pax-6   NCX/Ncx   CUTL1   POU6F1 (c2)   Cdc5   LHX3a/Lhx3a   c-Myb   Cart-1   Msx-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CTAGE6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTAGE6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q35

CTAGE6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTAGE6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M143459:  view genomic region     (about GC identifiers)

Start:
143,452,182 bp from pter      End:
143,454,843 bp from pter
Size:
2,662 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 142,790,348-142,793,009     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CTGE6_HUMAN, Q86UF2 (See protein sequence)
Recommended Name: cTAGE family member 6  
Size: 777 amino acids; 87900 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BC043153; Type=Frameshift; Positions=63;
Secondary accessions: A4FU29 Q3ZCM5

Explore the universe of human proteins at neXtProt for CTAGE6: NX_Q86UF2

Explore proteomics data for CTAGE6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UF2

  • CTAGE6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CTAGE6 Protein Expression
    REFSEQ proteins: NP_848656.2  
    ENSEMBL proteins: 
     ENSP00000474388  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral to membrane IEA--

    CTAGE6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q86UF2

    UniProtKB/Swiss-Prot: CTGE6_HUMAN, Q86UF2
    Similarity: Belongs to the cTAGE family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
         
    CTAGE6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CTAGE6:
     Synthetic lethal with Ras 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTAGE6

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    CTAGE6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about CTAGE6 / CTGE6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for CTAGE6 gene: 
    NM_178561.4  

    Unigene Cluster for CTAGE6:

    CTAGE family, member 6
    Hs.676333  [show with all ESTs]
    Unigene Representative Sequence: NM_178561
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000470691(uc003wdk.4)
    miRNA
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    Additional mRNA sequence: 

    BC043153.2 BC101323.1 BC101324.2 BC110410.1 

    3 DOTS entries:

    DT.40284638  DT.121037337  DT.97806985 

    2 AceView cDNA sequences:

    BC043153 AI651623 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTAGE6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CTAGE6 Expression
    About this image


    See CTAGE6 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.676333
        SABiosciences Custom PCR Arrays for CTAGE6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTAGE6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CTAGE6 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    30(a)
    1 → many
    5(36900539-36929278)
    lizard
    (Anolis carolinensis)
    Reptilia CTAGE56
    Uncharacterized protein
    31(a)
    1 → many
    1(23887867-23944107)
    zebrafish
    (Danio rerio)
    Actinopterygii ctage56
    CTAGE family, member 5
    33(a)
    1 → many
    17(12908906-12936163)
    fruit fly
    (Drosophila melanogaster)
    Insecta Tango16
    Transport and Golgi organization 1
    8(a)
    1 → many
    2L(6649388-6654574)
            Species with no ortholog for CTAGE6

    ENSEMBL Gene Tree for CTAGE6 (if available)
    TreeFam Gene Tree for CTAGE6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTAGE6 gene
    CTAGE15P  CTAGE41 2  CTAGE91 2  MIA22  MIA32  CTAGE52  CTAGE12  ENSG000002589412  
    CTAGE82  
    7 SIMAP similar genes for CTAGE6 using alignment to 1 protein entry:     CTGE6_HUMAN:
    CTAGE15    CTAGE4    CTAGE8    CTAGE9    CTAGE5    CTAGE1
    CTAGE3P

    CTAGE6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/32 SNPs in CTAGE6 are shown (see all 32)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs743007551,2
    C--143451711(+) TTTTTC/TCCCCC 1 -- int10--------
    rs2010334091,2
    --143451712(+) TTTTT-/CCCCCC 1 -- int10--------
    rs2003653861,2
    C,F--143453192(+) CCATTC/TGGGGC 2 P syn11Minor allele frequency- T:0.26EU 101
    rs2010249921,2
    C--143453343(+) CAGTCC/TGAGCT 2 Q R mis10--------
    rs2022183581,2
    F--143453389(+) AATAAC/GCTGCT 2 L V mis11Minor allele frequency- G:0.00EU 585
    rs178556591,2
    C--143453518(+) TTCTTC/TCTCTA 2 K E mis12Minor allele frequency- T:0.00NA 4
    rs2017067231,2
    C--143453523(+) CCTCTA/GTTCGG 2 T I mis10--------
    rs1997341181,2
    C--143453544(+) CCACTA/GTTAAT 2 T I mis10--------
    rs1921383451,2
    --143453556(+) TCCTAC/TAGAGT 2 Y C mis10--------
    rs2009077751,2
    C,F--143453661(+) AAGATT/GCTTGT 2 /E /A mis11Minor allele frequency- G:0.12EU 292

    HapMap Linkage Disequilibrium report for CTAGE6 (143452182 - 143454843 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CTAGE6: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CTAGE6
    DNA2.0 Custom Variant and Variant Library Synthesis for CTAGE6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTAGE6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CTAGE6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340307 HGNC: 28644 AceView: CTAGE6.1 Ensembl:ENSG00000271321 euGenes: HUgn340307
    ECgene: CTAGE6 H-InvDB: CTAGE6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTAGE6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CTAGE6 gene:
    Search GeneIP for patents involving CTAGE6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     See all of Abcam's Antibodies, Kits and Proteins for CTAGE6
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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CTAGE6
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTAGE6
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CTAGE6
     Browse SwitchGear Promoter luciferase reporter plasmids for CTAGE6
     Search ThermoFisher Antibodies for CTAGE6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTAGE6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CTAGE6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTAGE6
    Customized:
     lentivirus for stable overexpression of CTAGE6
     lentivirus expression plasmids for stable overexpression of CTAGE6
     adenovirus for overexpression of CTAGE6
     Search LSBio for Antibodies for CTAGE6
    Customized transgenic rodents for:
     Humanization
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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