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Aliases for CTAGE5 Gene

Aliases for CTAGE5 Gene

  • CTAGE Family Member 5, ER Export Factor 2 3 5
  • Meningioma Expressed Antigen 6 (Coiled-Coil Proline-Rich) 2 3
  • Meningioma-Expressed Antigen 6/11 3 4
  • CTAGE Family, Member 5 2 3
  • CTAGE Family Member 5 2 3
  • Protein CTAGE-5 3 4
  • MGEA11 3 4
  • MGEA6 3 4
  • MEA6 3 4
  • Cutaneous T-Cell Lymphoma-Associated Antigen 5 3
  • Melanoma Inhibitory Activity Protein 2 3
  • Melanoma Inhibitory Activity 2 3
  • MEA11 4
  • MIA2 3
  • MGEA 3

External Ids for CTAGE5 Gene

Previous HGNC Symbols for CTAGE5 Gene

  • MGEA
  • MGEA6

Previous GeneCards Identifiers for CTAGE5 Gene

  • GC14P038804
  • GC14P039734
  • GC14P019849

Summaries for CTAGE5 Gene

GeneCards Summary for CTAGE5 Gene

CTAGE5 (CTAGE Family Member 5, ER Export Factor) is a Protein Coding gene. Diseases associated with CTAGE5 include Cutaneous T Cell Lymphoma and Lymphoma. GO annotations related to this gene include enzyme activator activity. An important paralog of this gene is ENSG00000258941.

UniProtKB/Swiss-Prot for CTAGE5 Gene

  • Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.

Gene Wiki entry for CTAGE5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTAGE5 Gene

Genomics for CTAGE5 Gene

Regulatory Elements for CTAGE5 Gene

Enhancers for CTAGE5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F039380 0.2 ENCODE 24.7 +116.3 116276 1.3 CTAGE5 FBXO33 GEMIN2 SEC23A COILP1 ENSG00000271424
GH14F039374 0.4 ENCODE 24.1 +110.0 110044 1.6 JUN PLRG1 MNT CTAGE5 FBXO33 ENSG00000258941 ENSG00000271424 COILP1
GH14F039368 0.2 ENCODE 21.6 +103.4 103382 0.8 SOX13 CTCF PKNOX1 ZNF792 SAP130 ARID4B ZNF384 RAD21 RFX5 TEAD3 CTAGE5 ENSG00000271424 PIR47323
GH14F039376 0.9 Ensembl ENCODE 21.6 +111.9 111871 1.9 SMARCE1 HDAC1 RNF2 MAFG PLRG1 ARID1B JUND GATA3 HDAC2 KDM1A CTAGE5 FBXO33 SEC23A GEMIN2 ENSG00000271424 COILP1
GH14F039366 0.4 ENCODE 18.2 +102.2 102207 1.3 MXD3 ZIC2 CTAGE5 ENSG00000271424 PIR47323
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CTAGE5 on UCSC Golden Path with GeneCards custom track

Promoters for CTAGE5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001456827 1816 3801 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for CTAGE5 Gene

Chromosome:
14
Start:
39,265,284 bp from pter
End:
39,388,513 bp from pter
Size:
123,230 bases
Orientation:
Plus strand

Genomic View for CTAGE5 Gene

Genes around CTAGE5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTAGE5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTAGE5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTAGE5 Gene

Proteins for CTAGE5 Gene

  • Protein details for CTAGE5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15320-CTGE5_HUMAN
    Recommended name:
    cTAGE family member 5
    Protein Accession:
    O15320
    Secondary Accessions:
    • B3KRA6
    • B4DQS6
    • D3DSA6
    • G3XAC5
    • O00169
    • Q6MZN2
    • Q6P2R8
    • Q86TF6
    • Q8IX92
    • Q8IX93

    Protein attributes for CTAGE5 Gene

    Size:
    804 amino acids
    Molecular mass:
    90996 Da
    Quaternary structure:
    • Interacts with MIA3 (PubMed:21525241, PubMed:25202031, PubMed:27170179). Interacts with PREB; recruits PREB to endoplasmic reticulum exit sites (PubMed:25202031, PubMed:27170179). May interact with APOB (PubMed:27138255). May interact with COPII coat subunits SEC23A and SEC24C (PubMed:21525241).
    SequenceCaution:
    • Sequence=AAB86589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CTAGE5 Gene

neXtProt entry for CTAGE5 Gene

Post-translational modifications for CTAGE5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CTAGE5 Gene

Domains & Families for CTAGE5 Gene

Gene Families for CTAGE5 Gene

Protein Domains for CTAGE5 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CTAGE5 Gene

Graphical View of Domain Structure for InterPro Entry

O15320

UniProtKB/Swiss-Prot:

CTGE5_HUMAN :
  • The proline-rich domain (PRD) probably mediates interaction with the COPII coat subunits.
  • Belongs to the cTAGE family.
Domain:
  • The proline-rich domain (PRD) probably mediates interaction with the COPII coat subunits.
  • The coiled coil domains mediate interaction with MIA3 (PubMed:21525241). The first coiled coil domain mediates interaction with PREB (PubMed:25202031).
Family:
  • Belongs to the cTAGE family.
genes like me logo Genes that share domains with CTAGE5: view

Function for CTAGE5 Gene

Molecular function for CTAGE5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.

Gene Ontology (GO) - Molecular Function for CTAGE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21525241
GO:0008047 enzyme activator activity TAS 9356211
genes like me logo Genes that share ontologies with CTAGE5: view

Phenotypes for CTAGE5 Gene

GenomeRNAi human phenotypes for CTAGE5:
genes like me logo Genes that share phenotypes with CTAGE5: view

Animal Model Products

miRNA for CTAGE5 Gene

miRTarBase miRNAs that target CTAGE5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTAGE5 Gene

Localization for CTAGE5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTAGE5 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Endoplasmic reticulum exit sites. {ECO:0000269 PubMed:21525241, ECO:0000269 PubMed:25202031}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTAGE5 Gene COMPARTMENTS Subcellular localization image for CTAGE5 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CTAGE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070971 endoplasmic reticulum exit site IDA 21525241
genes like me logo Genes that share ontologies with CTAGE5: view

Pathways & Interactions for CTAGE5 Gene

SuperPathways for CTAGE5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTAGE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IMP,TAS --
GO:0032527 protein exit from endoplasmic reticulum IMP 21525241
GO:0035459 cargo loading into vesicle IMP 27170179
GO:0042632 cholesterol homeostasis IEA --
GO:0043085 positive regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with CTAGE5: view

No data available for Pathways by source and SIGNOR curated interactions for CTAGE5 Gene

Transcripts for CTAGE5 Gene

Unigene Clusters for CTAGE5 Gene

CTAGE family, member 5:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTAGE5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: -
SP2:
SP3: - -
SP4: - - -
SP5:

Relevant External Links for CTAGE5 Gene

GeneLoc Exon Structure for
CTAGE5
ECgene alternative splicing isoforms for
CTAGE5

Expression for CTAGE5 Gene

mRNA expression in normal human tissues for CTAGE5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTAGE5 Gene



Protein tissue co-expression partners for CTAGE5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTAGE5 Gene:

CTAGE5

SOURCE GeneReport for Unigene cluster for CTAGE5 Gene:

Hs.540038

mRNA Expression by UniProt/SwissProt for CTAGE5 Gene:

O15320-CTGE5_HUMAN
Tissue specificity: Isoform 5A is expressed only in testis (at the protein level). Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma.
genes like me logo Genes that share expression patterns with CTAGE5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for CTAGE5 Gene

Orthologs for CTAGE5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTAGE5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTAGE5 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia CTAGE5 34
  • 90.87 (n)
-- 35
  • 52 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CTAGE5 34
  • 88.49 (n)
-- 35
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100912115 34
  • 83.55 (n)
mouse
(Mus musculus)
Mammalia Ctage5 34 16 35
  • 83.31 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 37 (a)
OneToMany
chicken
(Gallus gallus)
Aves MIA2 34
  • 70.56 (n)
-- 35
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ctage5 34
  • 58.43 (n)
Str.4085 34
zebrafish
(Danio rerio)
Actinopterygii ctage5 34 35
  • 54.46 (n)
zgc56047 34
fruit fly
(Drosophila melanogaster)
Insecta Tango1 35
  • 10 (a)
OneToMany
Species where no ortholog for CTAGE5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTAGE5 Gene

ENSEMBL:
Gene Tree for CTAGE5 (if available)
TreeFam:
Gene Tree for CTAGE5 (if available)

Paralogs for CTAGE5 Gene

Variants for CTAGE5 Gene

Sequence variations from dbSNP and Humsavar for CTAGE5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10162564 --
rs1060878 --
rs1140952 --
rs17109109 --
rs17855895 --

Structural Variations from Database of Genomic Variants (DGV) for CTAGE5 Gene

Variant ID Type Subtype PubMed ID
esv1110364 CNV deletion 17803354
esv2748622 CNV deletion 23290073
esv3584293 CNV gain 25503493
esv3634143 CNV loss 21293372
nsv1053133 CNV gain 25217958
nsv1138292 CNV deletion 24896259
nsv476312 CNV novel sequence insertion 20440878
nsv84573 CNV deletion 16902084
nsv976333 CNV duplication 23825009
nsv977461 CNV duplication 23825009
nsv977462 CNV duplication 23825009

Variation tolerance for CTAGE5 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTAGE5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTAGE5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTAGE5 Gene

Disorders for CTAGE5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CTAGE5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CTGE5_HUMAN
  • Note=Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).

Relevant External Links for CTAGE5

Genetic Association Database (GAD)
CTAGE5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTAGE5
genes like me logo Genes that share disorders with CTAGE5: view

No data available for Genatlas for CTAGE5 Gene

Publications for CTAGE5 Gene

  1. cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites. (PMID: 21525241) Saito K. … Katada T. (Mol. Biol. Cell 2011) 2 4 64
  2. cDNA cloning and chromosomal mapping of a predicted coiled-coil proline-rich protein immunogenic in meningioma patients. (PMID: 9356211) Heckel D. … Meese E. (Hum. Mol. Genet. 1997) 2 4 64
  3. TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre- chylomicrons/VLDLs from the endoplasmic reticulum. (PMID: 27138255) Santos A.J. … Malhotra V. (J. Cell Biol. 2016) 4 64
  4. Dual function of cTAGE5 in collagen export from the endoplasmic reticulum. (PMID: 27170179) Tanabe T. … Katada T. (Mol. Biol. Cell 2016) 4 64
  5. Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export. (PMID: 25202031) Saito K. … Katada T. (J. Cell Biol. 2014) 4 64

Products for CTAGE5 Gene

Sources for CTAGE5 Gene

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