CTAGE4 Gene
protein-coding GIFtS: 32
GCID: GC07P143880
|
|
CTAGE family, member 4
| |
Aliases
for CTAGE4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CTAGE Family, Member 41 2 | | CTAGE-41 | | Protein CTAGE-42 3 | | FLJ436921 | | Cutaneous T-Cell Lymphoma-Associated Antigen 42 | | Cutaneous-T-Cell-Lymphoma-Specific Tumor Antigen 42 |
Export aliases for CTAGE4 gene to outside databasesPrevious GC identifers: GC07M143275 GC07P143318 GC07U901590 GC07P143509 GC07P143219 |
Summaries
for CTAGE4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CTGE4_HUMAN, Q8IX94Function: Tumor-associated antigen
|
Genomic Views
for CTAGE4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CTAGE4 gene promoter:
HFH-3 NCX/Ncx POU6F1 (c2) XBP-1 c-Ets-1 FOXI1 FOXJ2 (long isoform) HFH-1 c-Myb FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CTAGE4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTAGE4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q35 Ensembl cytogenetic band: 7q35 HGNC cytogenetic band: 7q35CTAGE4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P143880: view genomic region
(about GC identifiers)
Start:
|
143,880,548 bp from pter |
End:
|
143,883,173 bp from pter |
Size:
|
2,626 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 143,218,806-143,221,431 |
|
Proteins
for CTAGE4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CTGE4_HUMAN, Q8IX94 (See
protein sequence)Recommended Name: Cutaneous T-cell lymphoma-associated antigen 4 Size: 777 amino acids; 87989 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Miscellaneous: Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL). Also found in colorectal andbreast carcinomas, head and neck squamous cell carcinomas and melanoma
Sequence caution: Sequence=AAN77609.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAN77609.1; Type=Frameshift; Positions=643, 646, 662;
Secondary accessions: A8K871 O95046Explore the universe of human proteins at neXtProt for CTAGE4: NX_Q8IX94
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IX94
CTAGE4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_940897.2
ENSEMBL proteins: ENSP00000419539
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
CTAGE4 for ontologies About GeneDecksing
CTAGE4 Antibody Products:
Assay Products for CTAGE4: |
Protein
Domains /
Families
for CTAGE4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8IX94 UniProtKB/Swiss-Prot: CTGE4_HUMAN, Q8IX94Similarity: Belongs to the cTAGE family |
Function
for CTAGE4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CTGE4_HUMAN, Q8IX94Function: Tumor-associated antigen
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTAGE4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTAGE4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CTAGE4 (NM_198495) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTAGE4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CTAGE4 |
|
Pathways & Interactions
for CTAGE4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTAGE4
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
CTAGE4 for ontologies About GeneDecksing
|
Drugs & Compounds
for CTAGE4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CTAGE4
Search CenterWatch for drugs/clinical trials and news about CTAGE4 / CTGE4
|
Transcripts
for CTAGE4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CTAGE4 gene: NM_198495.2 Unigene Cluster for CTAGE4: CTAGE family, member 4 Hs.720693 [show with all ESTs]Unigene Representative Sequence: NM_1984951 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000486333
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTAGE4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTAGE4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CTAGE4 (NM_198495) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTAGE4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CTAGE4 |
Additional cDNA sequence: AF338232.1 XR_171693.1 3 DOTS entries: DT.97806985 DT.121037337 DT.40284638
GeneLoc Exon Structure
|
Expression
for CTAGE4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CTAGE4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CTAGE4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTAGE4
SOURCE GeneReport for Unigene cluster: Hs.720693
UniProtKB/Swiss-Prot: CTGE4_HUMAN, Q8IX94Tissue specificity: Expressed in testis, placenta and skin. Expressed at lower level in mammary gland and stomach
SABiosciences Custom PCR Arrays for CTAGE4
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CTAGE4 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTAGE4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTAGE4 |
Orthologs
for CTAGE4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CTAGE4 gene from 2/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
ctage56 |
CTAGE family, member 5 |
36(a) |
1 → many |
17(12908906-12936163) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Tango16 |
Transport and Golgi organization 1 |
7(a) |
1 → many |
2L(6649388-6654574) |
ENSEMBL Gene Tree for CTAGE4 (if available)
TreeFam Gene Tree for CTAGE4 (if available) |
Paralogs
for CTAGE4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CTAGE4 gene
- CTAGE91 2 CTAGE15P CTAGE6P ENSG000002589412 CTAGE12 CTAGE52 MIA32 CTAGE82
8 SIMAP similar genes for CTAGE4 using alignment to 1 protein entry: CTGE4_HUMAN:CTAGE8 CTAGE9 CTAGE6P LOC389592 LOC441294 CTAGE5
CTAGE1 CTAGE3P
CTAGE4 for paralogs About GeneDecksing
|
Genomic Variants
for CTAGE4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CTAGE4 (143880548 - 143883173 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 21 variations for CTAGE4
15/18 CNVs (see all 18): 0726 37567 32962 4571 70058 82235 94944 82244 2110 94940 94934 59622 3708 94936 82237
3 Inversions: 37283 59845 37282 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTAGE4 |
|
Disorders
/ Diseases
for CTAGE4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CTAGE4 for disorders About GeneDecksing
OMIM gene information: 608910
OMIM disorders: --
5  diseases for CTAGE4: About MalaCardscutaneous t cell lymphoma squamous cell carcinoma breast carcinoma carcinoma
melanoma
Export disorders for CTAGE4 gene to outside databases
|
Publications
for CTAGE4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CTAGE4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CTAGE4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing. (PubMed id 12839582)1, 2, 3 Usener D....Eichmuller S. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 3 Eichmueller S....Schadendorf D. (2001)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
|
External Searches for CTAGE4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CTAGE4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CTAGE4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CTAGE4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CTAGE4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CTAGE4 gene:
Search GeneIP for patents involving CTAGE4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CTAGE4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CTAGE4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTAGE4 | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CTAGE4 | | OriGene 3'-UTR Clone for CTAGE4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTAGE4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTAGE4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CTAGE4 | | OriGene Custom Protein Services for CTAGE4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTAGE4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTAGE4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTAGE4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTAGE4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTAGE4 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTAGE4 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CTAGE4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CTAGE4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for CTAGE4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CTAGE4 |
|
|
|
|
