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CTAGE4 Gene

protein-coding   GIFtS: 31
GCID: GC07P143880

CTAGE Family, Member 4

  Search for CTAGE4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CTAGE Family, Member 41 2
Cutaneous T-Cell Lymphoma-Associated Antigen 41 2
Protein CTAGE-42 3
cTAGE-42
CTAGE Family Member 42
Cutaneous-T-Cell-Lymphoma-Specific Tumor Antigen 42

External Ids:    HGNC: 247721   Entrez Gene: 1001285532   Ensembl: ENSG000002259327   OMIM: 6089105   UniProtKB: Q8IX943   

Export aliases for CTAGE4 gene to outside databases

Previous GC identifers: GC07M143275 GC07P143318 GC07U901590 GC07P143509 GC07P143219


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CTAGE4 Gene:
CTAGE4 (CTAGE family, member 4) is a protein-coding gene. An important paralog of this gene is MIA2.

UniProtKB/Swiss-Prot: CTGE4_HUMAN, Q8IX94
Function: Tumor-associated antigen




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CTAGE4 gene promoter:
         HFH-3   NCX/Ncx   POU6F1 (c2)   XBP-1   c-Ets-1   FOXI1   FOXJ2 (long isoform)   HFH-1   c-Myb   FOXJ2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CTAGE4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTAGE4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q35

CTAGE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTAGE4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P143880:  view genomic region     (about GC identifiers)

Start:
143,880,548 bp from pter      End:
143,883,173 bp from pter
Size:
2,626 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 143,218,806-143,221,431     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTGE4_HUMAN, Q8IX94 (See protein sequence)
Recommended Name: cTAGE family member 4  
Size: 777 amino acids; 87989 Da
Miscellaneous: Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL). Also found in
colorectal and breast carcinomas, head and neck squamous cell carcinomas and melanoma
Sequence caution: Sequence=AAN77609.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAN77609.1; Type=Frameshift; Positions=643, 646, 662;
Secondary accessions: A8K871 O95046

Explore the universe of human proteins at neXtProt for CTAGE4: NX_Q8IX94

Explore proteomics data for CTAGE4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CTAGE4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940897.2  
    ENSEMBL proteins: 
     ENSP00000419539  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8IX94

    UniProtKB/Swiss-Prot: CTGE4_HUMAN, Q8IX94
    Similarity: Belongs to the cTAGE family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTGE4_HUMAN, Q8IX94
    Function: Tumor-associated antigen

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
         
    Find genes that share ontologies with CTAGE4           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTGE4_HUMAN, Q8IX94: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CTAGE4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTAGE4
    Interactions:

        Search GeneGlobe Interaction Network for CTAGE4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CTAGE4 (ENSP000004195394) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNBENSP000003033154STRING: ENSP00000303315
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with CTAGE4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for CTAGE4 (CTGE4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTAGE4 gene: 
    NM_198495.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000486333
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTAGE4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CTAGE4 Expression
    About this image


    CTAGE4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    CTAGE4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTAGE4 Protein Expression

    UniProtKB/Swiss-Prot: CTGE4_HUMAN, Q8IX94
    Tissue specificity: Expressed in testis, placenta and skin. Expressed at lower level in mammary gland and stomach

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTAGE4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CTAGE4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    30(a)
    1 → many
    5(36900539-36929278) ENSGALG00000010189
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    31(a)
    1 → many
    1(23887867-23944107)
    zebrafish
    (Danio rerio)
    Actinopterygii ctage56
    CTAGE family, member 5
    35(a)
    1 → many
    17(12908906-12936163) ENSDARG00000023516
    fruit fly
    (Drosophila melanogaster)
    Insecta Tango16
    Transport and Golgi organization 1
    9(a)
    1 → many
    2L(6649388-6654574)
            Species with no ortholog for CTAGE4

    ENSEMBL Gene Tree for CTAGE4 (if available)
    TreeFam Gene Tree for CTAGE4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTAGE4 gene
    CTAGE81 2  CTAGE91 2  CTAGE15  CTAGE61 2  MIA22  MIA32  CTAGE52  CTAGE12  
    ENSG000002589412  
    7 SIMAP similar genes for CTAGE4 using alignment to 1 protein entry:     CTGE4_HUMAN:
    CTAGE8    CTAGE9    CTAGE15    CTAGE6    CTAGE5    CTAGE1
    CTAGE3P

    Find genes that share paralogs with CTAGE4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTAGE4 (see all 16)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009737851,2
    C--143878706(+) TGTAGC/GAAGTC 1 -- us2k10--------
    rs2007632271,2
    C--143879620(+) AAATC-/ATAGCAT 1 -- us2k10--------
    rs2010702221,2
    --143880962(+) GCAGC-/AGAAGAAG 1 -- cds10--------
    rs2016729161,2
    F--143882435(+) CCAGGG/ACAATC 2 /G syn11Minor allele frequency- A:0.03EU 117
    rs2012456611,2
    F--143882465(+) CCTCCA/TCAAAG 2 P syn11Minor allele frequency- T:0.01EU 377
    rs2002777281,2
    F--143882512(+) TGGACC/TAGCAG 2 P L mis11Minor allele frequency- T:0.02EU 533
    rs1998406511,2
    C,F--143882559(+) TGGATA/GGGTCA 2 R G mis11Minor allele frequency- G:0.07EU 277
    rs2010108061,2
    C,F--143882673(+) CTGGCC/TTTATT 2 L F mis11Minor allele frequency- T:0.24EU 456
    rs2007246851,2
    ----143880376(+) GATGTA/GAAGTG 1 -- us2k10--------
    rs2012255591,2
    ----143881318(+) TGAACT/CTAATA 2 /P /L mis11Minor allele frequency- C:0.00EU 583

    HapMap Linkage Disequilibrium report for CTAGE4 (143880548 - 143883173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CTAGE4 (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv24n31CNV Duplication19718026
    nsv821609CNV Duplication20802225
    nsv819701CNV Insertion19587683
    nsv831174CNV Loss17160897
    nsv831175CNV Loss17160897
    nsv508489CNV Loss20534489
    dgv7525n71CNV Loss21882294
    nsv831176CNV Loss17160897
    dgv7526n71CNV Gain21882294
    nsv433394CNV Gain18776910

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608910    OMIM disorders: --


    Find genes that share disorders with CTAGE4           About GenesLikeMe


    Export disorders for CTAGE4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTAGE4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CTAGE4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing. (PubMed id 12839582)1, 2, 3 Usener D.... Eichmueller S. (J. Invest. Dermatol. 2003)
    2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    3. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 3 Eichmueller S....Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Toward a complete human genome sequence. (PubMed id 9847074)1 Sulston J.E. and Waterston R. (Genome Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100128553 HGNC: 24772 Ensembl:ENSG00000225932 euGenes: HUgn100128553 ECgene: CTAGE4
    H-InvDB: CTAGE4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTAGE4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTAGE4 gene:
    Search GeneIP for patents involving CTAGE4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CTAGE4   OriGene Custom Protein Services for CTAGE4  

     
     
     Block miRNA regulation of human, mouse, rat CTAGE4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CTAGE4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTAGE4 Predesigned siRNA for gene silencing in human, mouse, rat CTAGE4
     QuantiFast Probe-based Assays in human, mouse, rat CTAGE4 Search QuantiTect SYBR Green Assays in human, mouse, rat CTAGE4
     Custom PCR Arrays for CTAGE4 Search Chromatin IP Primers for CTAGE4
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CTAGE4  Search GeneGlobe Interaction Network for CTAGE4
     Regulatory tfbs in CTAGE4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CTAGE4 GenScript cDNA clones with any tag delivered in your preferred vector for CTAGE4
     GenScript Custom Assay Services for CTAGE4 GenScript Custom overexpressing Cell Line Services for CTAGE4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CTAGE4 (CTGE4)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
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     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
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     See all of Abcam's Antibodies, Kits and Proteins for CTAGE4
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     Browse ProSpec Recombinant Proteins
     Proteins for CTAGE4
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     Browse ESI BIO Cell Lines and PureStem Progenitors for CTAGE4
     Gene Synthesis
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for CTAGE4
     Browse SwitchGear Promoter luciferase reporter plasmids for CTAGE4
     Search ThermoFisher Antibodies for CTAGE4
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CTAGE4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTAGE4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTAGE4
     LSBio Antibodies in human, mouse, rat for CTAGE4
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     Browse compounds at ApexBio
     Search Addgene for plasmids for CTAGE4
      Search eBioscience for proteins for CTAGE4
      Search eBioscience for elisas for CTAGE4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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