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Aliases for CTAGE4 Gene

Aliases for CTAGE4 Gene

  • CTAGE Family Member 4 2 3 5
  • Cutaneous T-Cell Lymphoma-Associated Antigen 4 2 3
  • CTAGE Family, Member 4 2 3
  • Protein CTAGE-4 3 4
  • Cutaneous-T-Cell-Lymphoma-Specific Tumor Antigen 4 3
  • CTAGE-4 3

External Ids for CTAGE4 Gene

Previous GeneCards Identifiers for CTAGE4 Gene

  • GC07M143275
  • GC07P143318
  • GC07U901590
  • GC07P143509
  • GC07P143880
  • GC07P143219

Summaries for CTAGE4 Gene

GeneCards Summary for CTAGE4 Gene

CTAGE4 (CTAGE Family Member 4) is a Protein Coding gene. Diseases associated with CTAGE4 include Cutaneous T Cell Lymphoma. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is CTAGE9.

UniProtKB/Swiss-Prot for CTAGE4 Gene

  • Tumor-associated antigen.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTAGE4 Gene

Genomics for CTAGE4 Gene

Regulatory Elements for CTAGE4 Gene

Enhancers for CTAGE4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CTAGE4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CTAGE4 Gene

144,183,455 bp from pter
144,186,080 bp from pter
2,626 bases
Plus strand

Genomic View for CTAGE4 Gene

Genes around CTAGE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTAGE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTAGE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTAGE4 Gene

Proteins for CTAGE4 Gene

  • Protein details for CTAGE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    cTAGE family member 4
    Protein Accession:
    Secondary Accessions:
    • A8K871
    • O95046

    Protein attributes for CTAGE4 Gene

    777 amino acids
    Molecular mass:
    87989 Da
    Quaternary structure:
    No Data Available
    • Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL). Also found in colorectal and breast carcinomas, head and neck squamous cell carcinomas and melanoma.
    • Sequence=AAN77609.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAN77609.1; Type=Frameshift; Positions=643, 646, 662; Evidence={ECO:0000305};

neXtProt entry for CTAGE4 Gene

Proteomics data for CTAGE4 Gene at MOPED

Post-translational modifications for CTAGE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTAGE4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTAGE4 Gene

Domains & Families for CTAGE4 Gene

Gene Families for CTAGE4 Gene

Protein Domains for CTAGE4 Gene


Suggested Antigen Peptide Sequences for CTAGE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cTAGE family.
  • Belongs to the cTAGE family.
genes like me logo Genes that share domains with CTAGE4: view

Function for CTAGE4 Gene

Molecular function for CTAGE4 Gene

UniProtKB/Swiss-Prot Function:
Tumor-associated antigen.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTAGE4 Gene

Localization for CTAGE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTAGE4 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CTAGE4 Gene COMPARTMENTS Subcellular localization image for CTAGE4 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CTAGE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CTAGE4: view

Pathways & Interactions for CTAGE4 Gene

SuperPathways for CTAGE4 Gene

No Data Available

Interacting Proteins for CTAGE4 Gene

Gene Ontology (GO) - Biological Process for CTAGE4 Gene


No data available for Pathways by source and SIGNOR curated interactions for CTAGE4 Gene

Drugs & Compounds for CTAGE4 Gene

No Compound Related Data Available

Transcripts for CTAGE4 Gene

mRNA/cDNA for CTAGE4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTAGE4 Gene

CTAGE family, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTAGE4 Gene

No ASD Table

Relevant External Links for CTAGE4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTAGE4 Gene

mRNA expression in normal human tissues for CTAGE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTAGE4 Gene

This gene is overexpressed in Testis (x5.8), Thyroid (x4.2), and Skin - Not Sun Exposed (Suprapubic) (x4.0).

Protein differential expression in normal tissues from HIPED for CTAGE4 Gene

This gene is overexpressed in Neutrophil (38.3) and Peripheral blood mononuclear cells (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTAGE4 Gene

SOURCE GeneReport for Unigene cluster for CTAGE4 Gene Hs.720693

mRNA Expression by UniProt/SwissProt for CTAGE4 Gene

Tissue specificity: Expressed in testis, placenta and skin. Expressed at lower level in mammary gland and stomach.
genes like me logo Genes that share expression patterns with CTAGE4: view

Protein tissue co-expression partners for CTAGE4 Gene

Primer Products

Orthologs for CTAGE4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTAGE4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC470576 35
  • 94.7 (n)
  • 89.41 (a)
(Bos Taurus)
Mammalia -- 36
  • 71 (a)
(Canis familiaris)
Mammalia -- 36
  • 45 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
(Mus musculus)
Mammalia Ctage5 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
(Gallus gallus)
Aves -- 36
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
(Danio rerio)
Actinopterygii ctage5 36
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tango1 36
  • 9 (a)
Species with no ortholog for CTAGE4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTAGE4 Gene

Gene Tree for CTAGE4 (if available)
Gene Tree for CTAGE4 (if available)

Paralogs for CTAGE4 Gene

(7) SIMAP similar genes for CTAGE4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTAGE4: view

Variants for CTAGE4 Gene

Sequence variations from dbSNP and Humsavar for CTAGE4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1731135 -- 144,183,124(+) AAACT(A/T)CCAAA upstream-variant-2KB
rs1731346 -- 144,184,788(+) CTGAA(C/G)GGCTG reference, missense
rs1731347 -- 144,184,789(+) TGAAG(A/G)GCTGG reference, missense
rs28551575 -- 144,185,101(+) TGAAA(C/T)GAGAG reference, missense
rs2258541 -- 144,184,777(+) CAGCC(A/G)TGCCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CTAGE4 Gene

Variant ID Type Subtype PubMed ID
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
nsv8227 CNV Gain+Loss 18304495
esv1682998 OTHER Inversion 17803354
dgv7520n71 CNV Gain 21882294
dgv2149e1 CNV Complex 17122850
dgv2150e1 CNV Complex 17122850
nsv831174 CNV Loss 17160897
dgv7521n71 CNV Gain 21882294
essv3984 CNV CNV 17122850
nsv7411 OTHER Inversion 18451855
dgv7522n71 CNV Gain 21882294
dgv7523n71 CNV Gain 21882294
dgv7524n71 CNV Gain+Loss 21882294
esv1003295 OTHER Inversion 20482838
dgv7525n71 CNV Loss 21882294
nsv821609 CNV Duplication 20802225
nsv824360 CNV Gain 20364138
dgv24n31 CNV Duplication 19718026
nsv819701 CNV Insertion 19587683
esv24292 CNV Gain+Loss 19812545
nsv831175 CNV Loss 17160897
nsv831176 CNV Loss 17160897
nsv433394 CNV Gain 18776910
nsv508489 CNV Loss 20534489
nsv469769 CNV Complex 16826518
nsv471646 CNV Gain+Loss 15918152
dgv7526n71 CNV Gain 21882294
nsv510970 OTHER Inversion 20534489
esv8347 OTHER Inversion 19470904
nsv515041 CNV Complex 21397061

Variation tolerance for CTAGE4 Gene

Gene Damage Index Score: 1.16; 23.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CTAGE4 Gene

Disorders for CTAGE4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CTAGE4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CTAGE4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CTAGE4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTAGE4 Gene

Publications for CTAGE4 Gene

  1. cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing. (PMID: 12839582) Usener D. … Eichmueller S. (J. Invest. Dermatol. 2003) 2 3 4 67
  2. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmueller S. … Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CTAGE4 Gene

Sources for CTAGE4 Gene