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Aliases for CTAGE1 Gene

Aliases for CTAGE1 Gene

  • Cutaneous T-Cell Lymphoma-Associated Antigen 1 2 3 2
  • Cutaneous T-Cell Lymphoma-Associated Antigen 2 2 3
  • Cancer/Testis Antigen 21.2 3 4
  • Protein CTAGE-2 3 4
  • CT21.1 3 4
  • CT21.2 3 4
  • Cancer/Testis Antigen Family 21, Member 1 3
  • Cancer/Testis Antigen Family 21, Member 2 3
  • Cancer/Testis Antigen Family 21 2
  • Cancer/Testis Antigen 21.1 4
  • CTAGE Family Member 2 3
  • Protein CTAGE-1 4
  • Member 1 2
  • Member 2 2
  • CTAGE-1 3
  • CTAGE-2 3
  • CTAGE2 4
  • CTAGE 3

External Ids for CTAGE1 Gene

Previous GeneCards Identifiers for CTAGE1 Gene

  • GC18M018247
  • GC18M019995
  • GC18M016841

Summaries for CTAGE1 Gene

GeneCards Summary for CTAGE1 Gene

CTAGE1 (Cutaneous T-Cell Lymphoma-Associated Antigen 1) is a Protein Coding gene. Diseases associated with CTAGE1 include cutaneous t cell lymphoma. An important paralog of this gene is CTAGE9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTAGE1 Gene

Genomics for CTAGE1 Gene

Regulatory Elements for CTAGE1 Gene

Genomic Location for CTAGE1 Gene

Start:
22,413,601 bp from pter
End:
22,417,915 bp from pter
Size:
4,315 bases
Orientation:
Minus strand

Genomic View for CTAGE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTAGE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTAGE1 Gene

Proteins for CTAGE1 Gene

  • Protein details for CTAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RT6-CTGE2_HUMAN
    Recommended name:
    cTAGE family member 2
    Protein Accession:
    Q96RT6
    Secondary Accessions:
    • A2RUF2

    Protein attributes for CTAGE1 Gene

    Size:
    745 amino acids
    Molecular mass:
    85282 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK63198.1; Type=Frameshift; Positions=741; Evidence={ECO:0000305};

    Alternative splice isoforms for CTAGE1 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for CTAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC47-CTGE1_HUMAN
    Recommended name:
    Cutaneous T-cell lymphoma-associated antigen 1
    Protein Accession:
    Q9HC47
    Secondary Accessions:
    • B0YIZ3

    Protein attributes for CTAGE1 Gene

    Size:
    74 amino acids
    Molecular mass:
    8406 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Cancer-testis antigen containing the epitope FVLFLFGGN which is detected in sera of CTCL patients according to PubMed:12839582. Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients. Detected by 5 of 15 sera of Mycosis fungoides patients and by 2 of 3 sera of Sezary syndrome patients, but not by any control sera. Expressed in around 35% of the tested CTCL tumors

    Alternative splice isoforms for CTAGE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTAGE1 Gene

Proteomics data for CTAGE1 Gene at MOPED

Post-translational modifications for CTAGE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTAGE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTAGE1 Gene

Domains for CTAGE1 Gene

Protein Domains for CTAGE1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CTAGE1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96RT6

UniProtKB/Swiss-Prot:

CTGE1_HUMAN :
  • Q96RT6
Family:
  • Belongs to the cTAGE family.
genes like me logo Genes that share domains with CTAGE1: view

No data available for Gene Families for CTAGE1 Gene

Function for CTAGE1 Gene

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTAGE1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CTAGE1 Gene

Localization for CTAGE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTAGE1 Gene

Membrane; Single-pass membrane protein.
Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTAGE1 Gene COMPARTMENTS Subcellular localization image for CTAGE1 gene
Compartment Confidence
endoplasmic reticulum 2
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CTAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CTAGE1: view

Pathways for CTAGE1 Gene

SuperPathways for CTAGE1 Gene

No Data Available

Interacting Proteins for CTAGE1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000375220%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000080059%0d%0a
Selected Interacting proteins: Q96RT6-CTGE2_HUMAN ENSP00000375220 for CTAGE1 Gene via MINT STRING

Gene Ontology (GO) - Biological Process for CTAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with CTAGE1: view

No data available for Pathways by source for CTAGE1 Gene

Transcripts for CTAGE1 Gene

mRNA/cDNA for CTAGE1 Gene

(12) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTAGE1 Gene

Cutaneous T-cell lymphoma-associated antigen 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTAGE1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTAGE1 Gene

No ASD Table

Relevant External Links for CTAGE1 Gene

GeneLoc Exon Structure for
CTAGE1
ECgene alternative splicing isoforms for
CTAGE1

Expression for CTAGE1 Gene

mRNA expression in normal human tissues for CTAGE1 Gene

mRNA differential expression in normal tissues according to GTEx for CTAGE1 Gene

This gene is overexpressed in Testis (50.3).

Protein differential expression in normal tissues for CTAGE1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (66.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CTAGE1 Gene

SOURCE GeneReport for Unigene cluster for CTAGE1 Gene Hs.406709

mRNA Expression by UniProt/SwissProt for CTAGE1 Gene

Q96RT6-CTGE2_HUMAN
Tissue specificity: Testis. Expressed in several cutaneous T-cell lymphoma (CTCL) cell lines, in head-neck carcinomas and carcinoma of ovarian tissues.
genes like me logo Genes that share expressions with CTAGE1: view

Expression partners for CTAGE1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CTAGE1 Gene

Orthologs for CTAGE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTAGE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTAGE1 35
  • 98.63 (n)
  • 97.54 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 73 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 45 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ctage5 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ctage5 36
  • 37 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tango1 36
  • 9 (a)
OneToMany
Species with no ortholog for CTAGE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTAGE1 Gene

ENSEMBL:
Gene Tree for CTAGE1 (if available)
TreeFam:
Gene Tree for CTAGE1 (if available)

Paralogs for CTAGE1 Gene

Paralogs for CTAGE1 Gene

Selected SIMAP similar genes for CTAGE1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTAGE1: view

Variants for CTAGE1 Gene

Sequence variations from dbSNP and Humsavar for CTAGE1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs948386 -- 22,418,847(-) GTGGG(C/G)ATACC upstream-variant-2KB
rs3813128 -- 22,415,303(-) TTTAT(C/T)TTATT utr-variant-3-prime
rs3813129 -- 22,415,240(-) GGGAG(C/T)TTTAT utr-variant-3-prime
rs3813130 -- 22,415,217(-) GCAGG(C/T)GGGGA utr-variant-3-prime
rs3841259 -- 22,415,092(-) aaaaa(-/A)gaaat utr-variant-3-prime

Relevant External Links for CTAGE1 Gene

HapMap Linkage Disequilibrium report
CTAGE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CTAGE1 Gene

Disorders for CTAGE1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CTAGE1 Gene in MalaCards »

(1) Diseases for CTAGE1 Gene including...

(1) University of Copenhagen DISEASES for CTAGE1 Gene

Relevant External Links for CTAGE1

Genetic Association Database (GAD)
CTAGE1
genes like me logo Genes that share disorders with CTAGE1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CTAGE1 Gene

Publications for CTAGE1 Gene

  1. cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing. (PMID: 12839582) Usener D. … Eichmueller S. (J. Invest. Dermatol. 2003) 2 3 4
  2. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmueller S. … Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  3. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3

Products for CTAGE1 Gene

Sources for CTAGE1 Gene

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