CTAGE1 Gene
protein-coding GIFtS: 43
GCID: GC18M019995
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|
cutaneous T-cell lymphoma-associated antigen 1
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Aliases
for CTAGE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cutaneous T-Cell Lymphoma-Associated Antigen 11 2 | | CTAGE-22 | | CT21.11 2 3 | | Cancer/Testis Antigen Family 21, Member 12 | | CT21.21 2 3 | | Cancer/Testis Antigen Family 21, Member 22 | | CTAGE1 2 | | Cutaneous T-Cell Lymphoma-Associated Antigen 22 | | Cancer/Testis Antigen 21.22 3 | | Protein CTAGE-22 | | CTAGE-12 | | CTAGE23 | | CTAGE-22 | | Cancer/Testis Antigen 21.13 | | CTAGE-12 | | Protein CTAGE-13 |
Export aliases for CTAGE1 gene to outside databasesPrevious GC identifers: GC18M018247 GC18M016841 |
Summaries
for CTAGE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CTAGE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CTAGE1 gene promoter:
STAT5B STAT1 STAT4 POU3F1 STAT6 STAT1beta STAT5A STAT1alpha STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CTAGE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTAGE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.2 Ensembl cytogenetic band: 18q11.2 HGNC cytogenetic band: 18q11.2CTAGE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M019995: view genomic region
(about GC identifiers)
Start:
|
19,993,564 bp from pter |
End:
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19,997,878 bp from pter |
Size:
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4,315 bases |
Orientation:
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minus strand |
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Proteins
for CTAGE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CTGE1_HUMAN, Q9HC47 (See
protein sequence)Recommended Name: Cutaneous T-cell lymphoma-associated antigen 1 Size: 74 amino acids; 8406 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Miscellaneous: Cancer-testis antigen containing the epitope FVLFLFGGN which is detected in sera of CTCL patientsaccording to PubMed:12839582. Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and inparticular in mycosis fungoides patients and in Sezary syndrome patients. Detected by 5 of 15 sera of Mycosisfungoides patients and by 2 of 3 sera of Sezary syndrome patients, but not by any control sera. Expressed in around35% of the tested CTCL tumors
Secondary accessions: B0YIZ3Alternative splicing: 2 isoforms: Q9HC47-1 Q96RT6-1 UniProtKB/Swiss-Prot: CTGE2_HUMAN, Q96RT6 (See
protein sequence) Recommended Name: Protein cTAGE-2 Size: 745 amino acids; 85282 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAK63198.1; Type=Frameshift; Positions=741;
Secondary accessions: A2RUF2Alternative splicing: 2 isoforms: Q96RT6-1 Q9HC47-1 Explore the universe of human proteins at neXtProt for CTAGE1: NX_Q96RT6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96RT6
CTAGE1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_758441.2
ENSEMBL proteins: ENSP00000375220
Human Recombinant Protein Products for CTAGE1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
CTAGE1 for ontologies About GeneDecksing
CTAGE1 Antibody Products:
Assay Products for CTAGE1: |
Protein
Domains /
Families
for CTAGE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9HC47 UniProtKB/Swiss-Prot: CTGE2_HUMAN, Q96RT6Similarity: Belongs to the cTAGE family |
Function
for CTAGE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTAGE1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTAGE1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CTAGE1 (NM_172241) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTAGE1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTAGE1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTAGE1 |
|
Pathways & Interactions
for CTAGE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTAGE1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for CTAGE1 (Q96RT62 ENSP000003752204) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
CTAGE1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CTAGE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CTAGE1
Search CenterWatch for drugs/clinical trials and news about CTAGE1 / CTGE2
|
Transcripts
for CTAGE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CTAGE1 gene (2 alternative transcripts): NM_022663.1 NM_172241.2 Unigene Cluster for CTAGE1: Cutaneous T-cell lymphoma-associated antigen 1 Hs.406709 [show with all ESTs]Unigene Representative Sequence: AF2730581 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000391403(uc002ktv.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTAGE1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTAGE1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CTAGE1 (NM_172241) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTAGE1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTAGE1 |
Additional cDNA sequence: AF177229.1 AF273058.1 BC031065.1 BC070128.1 BC132871.1 3 DOTS entries: DT.405788 DT.100726957 DT.97796772 12 AceView cDNA sequences: AF177229 NM_022663 AA399523 BC070128 AA398146 NM_172241 BU171364 AA868597 BX098172 AF273058 BC031065 BI465302
GeneLoc Exon Structure
|
Expression
for CTAGE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CTAGE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTATTTTC
About this image
See CTAGE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTAGE1
SOURCE GeneReport for Unigene cluster: Hs.406709
UniProtKB/Swiss-Prot: CTGE1_HUMAN, Q9HC47Tissue specificity: Testis. Expressed in several cutaneous T-cell lymphoma (CTCL) cell lines, in head-neck carcinomasand carcinoma of ovarian tissues
UniProtKB/Swiss-Prot: CTGE2_HUMAN, Q96RT6Tissue specificity: Testis. Not found in tumor
SABiosciences Custom PCR Arrays for CTAGE1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTAGE1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CTAGE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTAGE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTAGE1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTAGE1 |
Orthologs
for CTAGE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CTAGE1 gene from 2/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
ctage56 |
CTAGE family, member 5 |
36(a) |
1 → many |
17(12908906-12936163) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Tango16 |
Transport and Golgi organization 1 |
7(a) |
1 → many |
2L(6649388-6654574) |
ENSEMBL Gene Tree for CTAGE1 (if available)
TreeFam Gene Tree for CTAGE1 (if available) |
Paralogs
for CTAGE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CTAGE1 gene
- CTAGE42 CTAGE92 ENSG000002589412 CTAGE52 MIA32 CTAGE82
8 SIMAP similar genes for CTAGE1 using alignment to 3 protein entries: CTGE1_HUMAN (see all proteins):CTAGE5 CTAGE3P CTAGE6P LOC389592 LOC441294 CTAGE4
CTAGE8 CTAGE9
CTAGE1 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for CTAGE1 (see all 7)
PGOHUM00000248367 PGOHUM00000248402 PGOHUM00000248591 PGOHUM00000247604 PGOHUM00000239081
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Genomic Variants
for CTAGE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CTAGE1 (19993564 - 19997878 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CTAGE1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTAGE1 |
|
Disorders
/ Diseases
for CTAGE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CTAGE1 for disorders About GeneDecksing
OMIM gene information: 608856
OMIM disorders: --
5  diseases for CTAGE1: About MalaCardscutaneous t cell lymphoma mycosis fungoides tuberculosis melanoma
carcinoma
1 disease from the University of Copenhagen DISEASES database for CTAGE1:Cutaneous T cell lymphoma Export disorders for CTAGE1 gene to outside databases
|
Publications
for CTAGE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CTAGE1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CTAGE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing. (PubMed id 12839582)1, 2, 3 Usener D....Eichmuller S. (2003)
- Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 3 Eichmueller S....Schadendorf D. (2001)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Genome-wide association analyses identifies a suscept ibility locus for tuberculosis on chromosome 18q11.2. (PubMed id 20694014)1 Thye T....Hill A.V. (2010)
- DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
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External Searches for CTAGE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CTAGE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CTAGE1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CTAGE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CTAGE1 gene:
Search GeneIP for patents involving CTAGE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CTAGE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CTAGE1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTAGE1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTAGE1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CTAGE1 | | OriGene 3'-UTR Clone for CTAGE1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTAGE1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTAGE1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CTAGE1 | | OriGene Custom Protein Services for CTAGE1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTAGE1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTAGE1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTAGE1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTAGE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTAGE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTAGE1 |
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 | | | CTAGE1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTAGE1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTAGE1 |
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