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Aliases for CTAGE1 Gene

Aliases for CTAGE1 Gene

  • Cutaneous T-Cell Lymphoma-Associated Antigen 1 2 2 3 5
  • Cutaneous T-Cell Lymphoma-Associated Antigen 2 2 3
  • Cancer/Testis Antigen Family 21, Member 1 2 3
  • Cancer/Testis Antigen Family 21, Member 2 2 3
  • Cancer/Testis Antigen 21.2 3 4
  • Protein CTAGE-2 3 4
  • CT21.1 3 4
  • CT21.2 3 4
  • Cancer/Testis Antigen 21.1 4
  • CTAGE Family Member 2 3
  • Protein CTAGE-1 4
  • CTAGE-1 3
  • CTAGE-2 3
  • CTAGE2 4
  • CTAGE 3

External Ids for CTAGE1 Gene

Previous GeneCards Identifiers for CTAGE1 Gene

  • GC18M018247
  • GC18M019995
  • GC18M016841

Summaries for CTAGE1 Gene

GeneCards Summary for CTAGE1 Gene

CTAGE1 (Cutaneous T-Cell Lymphoma-Associated Antigen 1) is a Protein Coding gene. Diseases associated with CTAGE1 include Cutaneous T Cell Lymphoma and Lymphoma. An important paralog of this gene is MIA2.

Additional gene information for CTAGE1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTAGE1 Gene

Genomics for CTAGE1 Gene

Regulatory Elements for CTAGE1 Gene

Enhancers for CTAGE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H022391 1.3 FANTOM5 Ensembl ENCODE 0.3 +26.1 26077 1 RFX1 JUN ZNF398 ZNF518A FOSL1 ZFP69B NFIC ZNF366 ZNF692 ZNF629 CTAGE1 LOC105372019
GH18H022384 0.9 Ensembl ENCODE 0.3 +32.2 32226 1 ZBTB10 JUN MAX CEBPB CEBPG EP300 JUND POLR2A STAT3 FOS CTAGE1 LOC105372019
GH18H022355 0.8 ENCODE dbSUPER 0.2 +62.1 62143 0 TAF1 RAD21 NR2F2 EZH2 LOC105372019 CTAGE1
GH18H022417 0.2 ENCODE 0.7 -0.1 -108 0 CTAGE1 ATP7BP1
GH18H022351 0.2 dbSUPER 0.2 +65.9 65938 0 LOC105372019 CTAGE1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CTAGE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CTAGE1 Gene

Chromosome:
18
Start:
22,413,601 bp from pter
End:
22,417,915 bp from pter
Size:
4,315 bases
Orientation:
Minus strand

Genomic View for CTAGE1 Gene

Genes around CTAGE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTAGE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTAGE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTAGE1 Gene

Proteins for CTAGE1 Gene

  • Protein details for CTAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RT6-CTGE2_HUMAN
    Recommended name:
    cTAGE family member 2
    Protein Accession:
    Q96RT6
    Secondary Accessions:
    • A2RUF2

    Protein attributes for CTAGE1 Gene

    Size:
    745 amino acids
    Molecular mass:
    85282 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK63198.1; Type=Frameshift; Positions=741; Evidence={ECO:0000305};

    Alternative splice isoforms for CTAGE1 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for CTAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC47-CTGE1_HUMAN
    Recommended name:
    Cutaneous T-cell lymphoma-associated antigen 1
    Protein Accession:
    Q9HC47
    Secondary Accessions:
    • B0YIZ3

    Protein attributes for CTAGE1 Gene

    Size:
    74 amino acids
    Molecular mass:
    8406 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Cancer-testis antigen containing the epitope FVLFLFGGN which is detected in sera of CTCL patients according to PubMed:12839582. Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients. Detected by 5 of 15 sera of Mycosis fungoides patients and by 2 of 3 sera of Sezary syndrome patients, but not by any control sera. Expressed in around 35% of the tested CTCL tumors.

    Alternative splice isoforms for CTAGE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTAGE1 Gene

Post-translational modifications for CTAGE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTAGE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTAGE1 Gene

Domains & Families for CTAGE1 Gene

Gene Families for CTAGE1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CTAGE1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CTAGE1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96RT6

UniProtKB/Swiss-Prot:

CTGE1_HUMAN :
  • Belongs to the cTAGE family.
Family:
  • Belongs to the cTAGE family.
genes like me logo Genes that share domains with CTAGE1: view

Function for CTAGE1 Gene

Phenotypes From GWAS Catalog for CTAGE1 Gene

Phenotypes for CTAGE1 Gene

genes like me logo Genes that share phenotypes with CTAGE1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CTAGE1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTAGE1 Gene

Localization for CTAGE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTAGE1 Gene

Membrane; Single-pass membrane protein.
Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTAGE1 gene
Compartment Confidence
nucleus 2
endoplasmic reticulum 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CTAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CTAGE1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTAGE1 Gene

Pathways & Interactions for CTAGE1 Gene

SuperPathways for CTAGE1 Gene

No Data Available

Interacting Proteins for CTAGE1 Gene

Gene Ontology (GO) - Biological Process for CTAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with CTAGE1: view

No data available for Pathways by source and SIGNOR curated interactions for CTAGE1 Gene

Drugs & Compounds for CTAGE1 Gene

No Compound Related Data Available

Transcripts for CTAGE1 Gene

mRNA/cDNA for CTAGE1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTAGE1 Gene

Cutaneous T-cell lymphoma-associated antigen 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CTAGE1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CTAGE1 Gene

No ASD Table

Relevant External Links for CTAGE1 Gene

GeneLoc Exon Structure for
CTAGE1
ECgene alternative splicing isoforms for
CTAGE1

Expression for CTAGE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTAGE1 Gene

mRNA differential expression in normal tissues according to GTEx for CTAGE1 Gene

This gene is overexpressed in Testis (x50.3).

Protein differential expression in normal tissues from HIPED for CTAGE1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTAGE1 Gene



Protein tissue co-expression partners for CTAGE1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTAGE1 Gene:

CTAGE1

SOURCE GeneReport for Unigene cluster for CTAGE1 Gene:

Hs.406709

mRNA Expression by UniProt/SwissProt for CTAGE1 Gene:

Q96RT6-CTGE2_HUMAN
Tissue specificity: Testis. Expressed in several cutaneous T-cell lymphoma (CTCL) cell lines, in head-neck carcinomas and carcinoma of ovarian tissues.

Evidence on tissue expression from TISSUES for CTAGE1 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with CTAGE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTAGE1 Gene

Orthologs for CTAGE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTAGE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTAGE1 33
  • 98.63 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 73 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ctage5 34
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 45 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 34 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 33 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ctage5 34
  • 37 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tango1 34
  • 9 (a)
OneToMany
Species where no ortholog for CTAGE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTAGE1 Gene

ENSEMBL:
Gene Tree for CTAGE1 (if available)
TreeFam:
Gene Tree for CTAGE1 (if available)

Paralogs for CTAGE1 Gene

Paralogs for CTAGE1 Gene

(7) SIMAP similar genes for CTAGE1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTAGE1: view

Variants for CTAGE1 Gene

Sequence variations from dbSNP and Humsavar for CTAGE1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1001626340 -- 22,419,616(+) CAACA(A/C/T)GGTGA upstream-variant-2KB
rs1001824798 -- 22,415,947(+) TTGAC(C/T)CATCC reference, missense
rs1002629093 -- 22,414,752(+) TATAT(A/G)ATTCT utr-variant-3-prime
rs1002673509 -- 22,414,536(+) GAGGG(C/T)GTCTC utr-variant-3-prime
rs1003677600 -- 22,413,540(+) GTGTT(A/G)CCTCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CTAGE1 Gene

Variant ID Type Subtype PubMed ID
dgv3325n100 CNV gain 25217958
nsv978620 CNV duplication 23825009

Variation tolerance for CTAGE1 Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTAGE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTAGE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTAGE1 Gene

Disorders for CTAGE1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CTAGE1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CTAGE1

Genetic Association Database (GAD)
CTAGE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTAGE1
genes like me logo Genes that share disorders with CTAGE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTAGE1 Gene

Publications for CTAGE1 Gene

  1. cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing. (PMID: 12839582) Usener D … Eichmüller S (The Journal of investigative dermatology 2003) 2 3 4 60
  2. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmuller S … Schadendorf D (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60
  5. Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients. (PMID: 24850846) Litvinov IV … Sasseville D (Clinical cancer research : an official journal of the American Association for Cancer Research 2014) 3 60

Products for CTAGE1 Gene

Sources for CTAGE1 Gene

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