Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CTAGE1 Gene

Aliases for CTAGE1 Gene

  • Cutaneous T-Cell Lymphoma-Associated Antigen 1 2 3 2 5
  • Cutaneous T-Cell Lymphoma-Associated Antigen 2 2 3
  • Cancer/Testis Antigen 21.2 3 4
  • Protein CTAGE-2 3 4
  • CT21.1 3 4
  • CT21.2 3 4
  • Cancer/Testis Antigen Family 21, Member 1 3
  • Cancer/Testis Antigen Family 21, Member 2 3
  • Cancer/Testis Antigen Family 21 2
  • Cancer/Testis Antigen 21.1 4
  • Protein CTAGE-1 4
  • Member 1 2
  • Member 2 2
  • CTAGE-1 3
  • CTAGE-2 3
  • CTAGE2 4
  • CTAGE 3

External Ids for CTAGE1 Gene

Previous GeneCards Identifiers for CTAGE1 Gene

  • GC18M018247
  • GC18M019995
  • GC18M016841

Summaries for CTAGE1 Gene

GeneCards Summary for CTAGE1 Gene

CTAGE1 (Cutaneous T-Cell Lymphoma-Associated Antigen 1) is a Protein Coding gene. Diseases associated with CTAGE1 include Cutaneous T Cell Lymphoma and Lymphoma. An important paralog of this gene is CTAGE9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTAGE1 Gene

Genomics for CTAGE1 Gene

Regulatory Elements for CTAGE1 Gene

Enhancers for CTAGE1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CTAGE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CTAGE1 Gene

22,413,601 bp from pter
22,417,915 bp from pter
4,315 bases
Minus strand

Genomic View for CTAGE1 Gene

Genes around CTAGE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTAGE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTAGE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTAGE1 Gene

Proteins for CTAGE1 Gene

  • Protein details for CTAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    cTAGE family member 2
    Protein Accession:
    Secondary Accessions:
    • A2RUF2

    Protein attributes for CTAGE1 Gene

    745 amino acids
    Molecular mass:
    85282 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK63198.1; Type=Frameshift; Positions=741; Evidence={ECO:0000305};

    Alternative splice isoforms for CTAGE1 Gene

  • Protein details for CTAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cutaneous T-cell lymphoma-associated antigen 1
    Protein Accession:
    Secondary Accessions:
    • B0YIZ3

    Protein attributes for CTAGE1 Gene

    74 amino acids
    Molecular mass:
    8406 Da
    Quaternary structure:
    No Data Available
    • Cancer-testis antigen containing the epitope FVLFLFGGN which is detected in sera of CTCL patients according to PubMed:12839582. Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients. Detected by 5 of 15 sera of Mycosis fungoides patients and by 2 of 3 sera of Sezary syndrome patients, but not by any control sera. Expressed in around 35% of the tested CTCL tumors.

    Alternative splice isoforms for CTAGE1 Gene


neXtProt entry for CTAGE1 Gene

Proteomics data for CTAGE1 Gene at MOPED

Post-translational modifications for CTAGE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTAGE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTAGE1 Gene

Domains & Families for CTAGE1 Gene

Gene Families for CTAGE1 Gene

Protein Domains for CTAGE1 Gene


Suggested Antigen Peptide Sequences for CTAGE1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cTAGE family.
  • Belongs to the cTAGE family.
genes like me logo Genes that share domains with CTAGE1: view

Function for CTAGE1 Gene

Phenotypes for CTAGE1 Gene

genes like me logo Genes that share phenotypes with CTAGE1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTAGE1 Gene

Localization for CTAGE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTAGE1 Gene

Membrane; Single-pass membrane protein.
Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CTAGE1 Gene COMPARTMENTS Subcellular localization image for CTAGE1 gene
Compartment Confidence
endoplasmic reticulum 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CTAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CTAGE1: view

Pathways & Interactions for CTAGE1 Gene

SuperPathways for CTAGE1 Gene

No Data Available

Interacting Proteins for CTAGE1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q96RT6-CTGE2_HUMAN ENSP00000375220 for CTAGE1 Gene via MINT STRING

Gene Ontology (GO) - Biological Process for CTAGE1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CTAGE1 Gene

Drugs & Compounds for CTAGE1 Gene

No Compound Related Data Available

Transcripts for CTAGE1 Gene

mRNA/cDNA for CTAGE1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTAGE1 Gene

Cutaneous T-cell lymphoma-associated antigen 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTAGE1 Gene

No ASD Table

Relevant External Links for CTAGE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTAGE1 Gene

mRNA expression in normal human tissues for CTAGE1 Gene

mRNA differential expression in normal tissues according to GTEx for CTAGE1 Gene

This gene is overexpressed in Testis (x50.3).

Protein differential expression in normal tissues from HIPED for CTAGE1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CTAGE1 Gene

SOURCE GeneReport for Unigene cluster for CTAGE1 Gene Hs.406709

mRNA Expression by UniProt/SwissProt for CTAGE1 Gene

Tissue specificity: Testis. Expressed in several cutaneous T-cell lymphoma (CTCL) cell lines, in head-neck carcinomas and carcinoma of ovarian tissues.
genes like me logo Genes that share expression patterns with CTAGE1: view

Protein tissue co-expression partners for CTAGE1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CTAGE1 Gene

Orthologs for CTAGE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTAGE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTAGE1 35
  • 98.63 (n)
  • 97.54 (a)
(Bos Taurus)
Mammalia -- 36
  • 73 (a)
(Canis familiaris)
Mammalia -- 36
  • 45 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
(Mus musculus)
Mammalia Ctage5 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
(Gallus gallus)
Aves -- 36
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
(Danio rerio)
Actinopterygii ctage5 36
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tango1 36
  • 9 (a)
Species with no ortholog for CTAGE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTAGE1 Gene

Gene Tree for CTAGE1 (if available)
Gene Tree for CTAGE1 (if available)

Paralogs for CTAGE1 Gene

(7) SIMAP similar genes for CTAGE1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTAGE1: view

Variants for CTAGE1 Gene

Sequence variations from dbSNP and Humsavar for CTAGE1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs9946136 - 22,415,768(+) TCTTA(C/T)GAACG reference, missense
rs7232121 -- 22,413,489(+) GAAAA(C/G)AAAAT downstream-variant-500B
rs8093101 -- 22,414,381(+) CTTTT(A/C)TTTTA utr-variant-3-prime
rs9959174 -- 22,419,791(+) aagac(G/T)ttgtc upstream-variant-2KB
rs7227471 -- 22,419,786(+) agagc(A/G)agact upstream-variant-2KB

Variation tolerance for CTAGE1 Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CTAGE1 Gene

Disorders for CTAGE1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CTAGE1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CTAGE1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CTAGE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTAGE1 Gene

Publications for CTAGE1 Gene

  1. cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing. (PMID: 12839582) Usener D. … Eichmueller S. (J. Invest. Dermatol. 2003) 2 3 4 67
  2. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmueller S. … Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  3. Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients. (PMID: 24850846) Litvinov I.V. … Sasseville D. (Clin. Cancer Res. 2014) 3
  4. Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features. (PMID: 22752306) Yuan E. … Malinowska I.A. (Hum. Mol. Genet. 2012) 3
  5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3

Products for CTAGE1 Gene

Sources for CTAGE1 Gene