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CTAG2 Gene

protein-coding   GIFtS: 50

GC0XM153533
cancer/testis antigen 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CAMEL 1, 2
CT2 3
CT6.2 3
ESO2 1, 2, 3
LAGE-1 1, 2, 3
LAGE-2b 2
LAGE1 1, 3
MGC138724 1, 2
MGC3803 1, 2
OTTHUMP00000026043 2
OTTHUMP00000026044 2
Descriptions
Autoimmunogenic cancer/testis antigen NY-ESO-2 3
CTL-recognized antigen on melanoma 2
Cancer/testis antigen 6.2 3
L antigen family member 1 3
LAGE-1a protein 2
cancer/testis antigen 2 2
External Ids
HGNC: 24921
Entrez Gene: 308482
UniProtKB: O756383
Ensembl: ENSG000001268907
Search outside databases for aliases for CTAG2 gene

Previous GC identifers: GC0XM147943 GC0XM150260 GC0XM151465 GC0XM152347 GC0XM153443

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CTAG2 gene  

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

CTAG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM153533:     (about GC identifiers)

Start:
153,533,445 bp from pter
End:
153,535,036 bp from pter
Size:
1,592 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011726.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CTAG2_HUMAN, O75638 (See protein sequence)
Recommended Name: Cancer/testis antigen 2  
Size: 210 amino acids; 21120 Da
Subcellular location: Isoform LAGE-1A: Membrane; Single-pass membrane protein (Potential)
PDB structures from and Proteopedia :
2BNQ (3D)    
Secondary accessions: O75637 Q0VIL6 Q14CD6 Q2Z1N4 Q9BU80 Q9UJ89 Q9Y479
Alternative splicing: 2 isoforms:  O75638-1   O75638-2   

REFSEQ proteins (2 alternative transcripts): 
NP_066274.1  NP_758965.1  


ENSEMBL proteins: 
ENSP00000358598 ENSP00000247306 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (CTAG2)
Browse Abnova for Human Recombinant Proteins
              OriGene Purified Recombinant Human Protein: CTAG2 

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005575 cellular_component ND--
GO:0005813 centrosome IDA11256614
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for CTAG2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for CTAG2
Browse R&D Systems for Antibodies
Antibodies from Abcam (CTAG2), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (CTAG2)
Novus Biologicals Antibody for CTAG2

Assays for CTAG2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR015419 Pcc1


   GeneDecks  CTAG2 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry O75638

ProtoNet protein and cluster: O75638

UniProtKB/Swiss-Prot: CTAG2_HUMAN, O75638
Domain: A transmembrane domain is present in isoform LAGE-1A
Similarity: Belongs to the CTAG family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (CTAG2)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_172377

              Applied Biosystems Silencer® siRNAs for CTAG2

              Sigma-Aldrich siRNA for CTAG2  
                     Sigma-Aldrich shRNA for CTAG2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_020994
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_020994
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_020994 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_020994

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003674 molecular_function ND--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Interacting proteins for CTAG2 (ENSP000002473063) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
MAGEA4ENSP000002763443STRING (score=.9)
MAGEC1ENSP000002858793STRING (score=.72)
CRYZENSP000003393993STRING (score=.718)
SSX1ENSP000003661183STRING (score=.718)
MAGEC2ENSP000003546603STRING (score=.714)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008150 biological_process ND--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CTAG2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (CTAG2)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_172377

              Sigma-Aldrich siRNA for CTAG2  
                     Sigma-Aldrich shRNA for CTAG2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_020994  NM_172377  

REFSEQ mRNAs for CTAG2 gene (2 alternative transcripts): 

NM_020994.2   NM_172377.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_020994  NM_172377  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_020994
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_020994
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_020994 

Additional cDNA sequence: BC114933.1 

2 DOTS entries:

DT.100018675  DT.121283813 

24/28 AceView cDNA sequences (see all 28 ):

NM_020994 BU629220 AJ223041 BX279602 AJ012834 BM719406 NM_172377 AJ012835 
AJ012833 AJ223040 BM684237 CA424840 BI856831 BI861547 BC002833 BM797218 
BG575764 BE274123 BE410952 BE390259 BE276194 BE410697 BE391232 BE387918 

highest scoring ESTs for CTAG2:

AJ223040 AJ012833 AJ012834 AJ012835 AJ223041 BC002833 BE274123 BE276194 BE385880 BE387918 

Unigene Clusters for CTAG2:

Cancer/testis antigen 2
Hs.87225  [show with all ESTs], Hs.713312  [show with all ESTs]
Unigene Representative Sequences: AJ223040, BE385880


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CTAG2

ExUns: 1a · 1b ^ 2 ^ 3
SP1:                        
SP2:                        

About this scheme

ECgene alternative splicing isoforms for CTAG2

2 Ensembl transcripts including schematic representations:
ENST00000369585  ENST00000247306  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CTAG2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for CTAG2

1 / 2 / 3

6 probe-sets matching CTAG2 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

34009_at2, 3 U95-A 3 1.00 0.58 0.41 0.35 AJ223040 1.00 1.00 1.00 1

33637_g_at2, 3 U95-A 3 1.00 0.33 1.00 1.00 U87459 0.40 0.27 0.34 3

207337_at2, 3 U133-A 1 1.00 1.00 -- -- NM_020994 0.60 1.00 0.82 1

215733_x_at2, 3 U133-A 3 1.00 0.64 -- -- AJ012833 0.80 1.00 0.91 1

207337_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

215733_x_at2 U133Plus2 3 1.00 0.64 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.87225 Hs.713312

Expression variation in blood from EXPOLDB for CTAG2

UniProtKB/Swiss-Prot: CTAG2_HUMAN, O75638
Tissue specificity: Testis and very low level in placenta and in some uterus samples. Observed in
25-50% of tumor samples of melanomas, non-small-cell lung carcinomas, bladder, prostate and head
and neck cancers

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

ENSEMBL Gene Tree for CTAG2
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for CTAG2 gene
CTAG1A1 2  CTAG1B1 2  LAGE32  

Pseudogenes
1 related pseudogene


(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/24 NCBI SNPs in CTAG2 are shown (see all 24 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 16)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs20758971,2
C,F,H153533375(-) GGTTGT/CAGGGG 2 -- ng513Minor allele frequency- C:0.48EA WA 300
rs59870031,2
C,F,H153534074(+) CATGGG/CCGACG 2 A/P mis1 ese39Minor allele frequency- C:0.03EU EA WA NA 644
rs173280911,2
C,F153534719(+) CAACTG/CAAGCA 2 E/Q mis13Minor allele frequency- C:0.44NA 115
--
rs59452191,2
C153537025(+) CCCCCC/TGGAGC 2 -- ng310--------
rs43265591,2
A,C,F,H153534024(+) GGGAGA/CGGTGC 2 P/P syn1 trp311Minor allele frequency- C:0.47EA WA NA 829
rs356188491,2
F153534039(-) CTGTCC/TCGGGA 2 S/S syn11Minor allele frequency- T:0.04NA 50
--
rs38297811,2
--153535887(-) GCACCC/GAGCAG 2 -- ng310--------
--
rs38297751,2
--153535900(-) CAGAAA/GTAAGC 2 -- ng310--------
--
rs344029641,2
--153534967(+) TGCCCC/TGGCCT 2 Q/R mis10--------
--
rs350142691,2
--153536571(+) CCCAG-/GAAGGG 2 -- ng310--------
About this table

HapMap Linkage Disequilibrium images for CTAG2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300396

6 Novoseek disease relationships for CTAG2 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma 45.57 16 11120859 (3), 12538712 (3), 15623618 (2), 10399963 (1) (see all 7)
cancer 44.57 9 17899192 (3), 16187088 (2), 11531257 (1), 15623618 (1) (see all 6)
esophageal carcinoma 40.42 3 11531257 (2), 16438850 (1)
tumors 39.83 20 16187088 (2), 12538712 (2), 14522938 (2), 10399963 (1) (see all 13)
nsclc 31.33 3 15061963 (1), 16353146 (1), 16299236 (1)
metastasis 0.00 1 16091172 (1)
About this table

Human Genome Epidemiology Navigator: CTAG2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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10/42 PubMed articles for CTAG2 gene (see all 42 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 30848 HGNC: 2492 AceView: CTAG2 Ensembl:ENSG00000126890 euGenes: HUgn30848
ECgene: CTAG2 H-InvDB: CTAG2
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for CTAG2 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for CTAG2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for CTAG2 Antibodies for CTAG2
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for CTAG2 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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(CTAG2)
 Antibodies (CTAG2)
 Tagged/untagged cDNA clones
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 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for CTAG2




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for CTAG2

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