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Aliases & Descriptions for CTAG2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CAMEL 1 , 2 CT2 3 CT6.2 3 ESO2 1 , 2 , 3 LAGE-1 1 , 2 , 3 LAGE-2b 2 LAGE1 1 , 3 MGC138724 1 , 2 MGC3803 1 , 2 OTTHUMP00000026043 2 OTTHUMP00000026044 2
Descriptions Autoimmunogenic cancer/testis antigen NY-ESO-2 3 CTL-recognized antigen on melanoma 2 Cancer/testis antigen 6.2 3 L antigen family member 1 3 LAGE-1a protein 2 cancer/testis antigen 2 2
Search outside databases for aliases for CTAG2 genePrevious GC identifers: GC0XM147943 GC0XM150260 GC0XM151465 GC0XM152347 GC0XM153443
Summaries for CTAG2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Location for CTAG2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the CTAG2 gene Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28 CTAG2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM153533:
(about GC identifiers )
Start:
153,533,445 bp from pter
End:
153,535,036 bp from pter
Size:
1,592 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000023.9 NT_011726.13 Proteins for CTAG2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: CTAG2_HUMAN, O75638 (See
protein sequence )Recommended Name: Cancer/testis antigen 2 Size : 210 amino acids; 21120 Da
Subcellular location : Isoform LAGE-1A: Membrane; Single-pass membrane protein (Potential)
PDB structures from and Proteopedia : 2BNQ (3D)
 
Secondary accessions : O75637 Q0VIL6 Q14CD6 Q2Z1N4 Q9BU80 Q9UJ89 Q9Y479Alternative splicing : 2 isoforms : O75638-1 O75638-2
REFSEQ proteins (2 alternative transcripts):
NP_066274.1 NP_758965.1 ENSEMBL proteins: ENSP00000358598 ENSP00000247306 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: CTAG2 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for CTAG2: Assays for CTAG2:
Protein
Domains/ Families for CTAG2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O75638 ProtoNet protein and cluster: O75638
UniProtKB/Swiss-Prot: CTAG2_HUMAN, O75638 Domain : A transmembrane domain is present in isoform LAGE-1ASimilarity : Belongs to the CTAG family
Gene Function for CTAG2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_172377 Applied Biosystems Silencer ® siRNAs for CTAG2 Sigma-Aldrich siRNA for CTAG2 Sigma-Aldrich shRNA for CTAG2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_020994                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_020994                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_020994  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_020994 1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND --
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Pathways & Interactions for CTAG2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5 Interacting proteins for CTAG2 (ENSP00000247306 3 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008150 biological_process
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Drugs & Compounds for CTAG2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for CTAG2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_172377 Sigma-Aldrich siRNA for CTAG2 Sigma-Aldrich shRNA for CTAG2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_020994 NM_172377
REFSEQ mRNAs for CTAG2 gene (2 alternative transcripts): NM_020994.2 NM_172377.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_020994 NM_172377
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_020994                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_020994                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_020994  
Additional cDNA sequence: BC114933.1
2 DOTS entries : DT.100018675 DT.121283813
24/28 AceView cDNA sequences (see all 28
):NM_020994 BU629220 AJ223041 BX279602 AJ012834 BM719406 NM_172377 AJ012835 AJ012833 AJ223040 BM684237 CA424840 BI856831 BI861547 BC002833 BM797218 BG575764 BE274123 BE410952 BE390259 BE276194 BE410697 BE391232 BE387918
highest scoring ESTs for CTAG2 :AJ223040 AJ012833 AJ012834 AJ012835 AJ223041 BC002833 BE274123 BE276194 BE385880 BE387918
Unigene Clusters for CTAG2: Cancer/testis antigen 2 Hs.87225 [show with all ESTs ] , Hs.713312 [show with all ESTs ] Unigene Representative Sequences: AJ223040 , BE385880 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for CTAG2 ExUns: 1a · 1b ^ 2 ^ 3 SP1 :         SP2 :        
About this scheme ECgene alternative splicing isoforms for CTAG2 2 Ensembl transcripts including schematic representations : ENST00000369585
ENST00000247306
Expression for CTAG2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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CTAG2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for CTAG2 1 / 2 / 3
6 probe-sets matching CTAG2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene clusters: Hs.87225 Hs.713312 Expression variation in blood from EXPOLDB for CTAG2
UniProtKB/Swiss-Prot: CTAG2_HUMAN, O75638 Tissue specificity : Testis and very low level in placenta and in some uterus samples. Observed in25-50% of tumor samples of melanomas, non-small-cell lung carcinomas, bladder, prostate and headand neck cancers
Orthologs for CTAG2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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ENSEMBL Gene Tree for CTAG2 Paralogs for CTAG2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for CTAG2 gene CTAG1A 1 2 CTAG1B 1 2 LAGE3 2 Pseudogenes 1 related pseudogene
SNPs/Variants for CTAG2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for CTAG2 (up to first 250kb)
Disorders & Mutations for CTAG2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 300396 6 Novoseek disease relationships for CTAG2 gene
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma
45.57
16
11120859 (3), 12538712 (3), 15623618 (2), 10399963 (1) (see all 7 )
cancer
44.57
9
17899192 (3), 16187088 (2), 11531257 (1), 15623618 (1) (see all 6 )
esophageal carcinoma
40.42
3
11531257 (2), 16438850 (1)
tumors
39.83
20
16187088 (2), 12538712 (2), 14522938 (2), 10399963 (1) (see all 13 )
nsclc
31.33
3
15061963 (1), 16353146 (1), 16299236 (1)
metastasis
0.00
1
16091172 (1)
About this table Human Genome Epidemiology Navigator: CTAG2 (1 document)
Medical News for CTAG2 (Possibly Related Articles in
Doctor's Guide )
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Publications for CTAG2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/42 PubMed articles for CTAG2 gene (see all 42
): Interleukin-2-induced, melanoma-specific T cells recognize CAMEL, an unexpected translation product of LAGE-1. (PubMed id 10399963) 1, 2, 3, 4 Aarnoudse C.A....Schrier P.I. (1999) LAGE-1, a new gene with tumor specificity. (PubMed id 9626360) 2, 3, 4 Lethe B.G.... Boon T. (1998) Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients. (PubMed id 17899192) 1, 3, 4 Shao Y....Zhao H.-T. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes. (PubMed id 11709543) 3, 4 Aradhya S....Nelson D.L. (2001) A new specific gene expression in squamous cell carcinoma of the esophagus detected using representational difference analysis and cDNA microarray. (PubMed id 16446548) 1, 3 Kan T....Shimada Y. (2006) CD4+ Th2 cell recognition of HLA-DR-restricted epitopes derived from CAMEL: a tumor antigen translated in an alternative open reading frame. (PubMed id 12538712) 1, 3 Slager E.H....Griffioen M. (2003) NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer. (PubMed id 14522938) 1, 3 Odunsi K....Old L.J. (2003) Efficient simultaneous presentation of NY-ESO-1/LAGE-1 primary and nonprimary open reading frame-derived CTL epitopes in melanoma. (PubMed id 11120859) 1, 3 Rimoldi D....Valmori D. (2000) Identification of multiple HLA-DR-restricted epitopes of the tumor-associated antigen CAMEL by CD4+ Th1/Th2 lymphocytes. (PubMed id 15067093) 1, 3 Slager E.H....Osanto S. (2004)
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Genome Databases showing CTAG2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Specialized Databases showing CTAG2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for CTAG2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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