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Aliases for CTAG2 Gene

Aliases for CTAG2 Gene

  • Cancer/Testis Antigen 2 2 3
  • Autoimmunogenic Cancer/Testis Antigen NY-ESO-2 3 4
  • CTL-Recognized Antigen On Melanoma 2 3
  • Cancer/Testis Antigen 6.2 3 4
  • L Antigen Family Member 1 3 4
  • LAGE-1a Protein 2 3
  • LAGE-1 3 4
  • CAMEL 3 6
  • CT6.2 3 4
  • LAGE1 4 6
  • ESO2 3 4
  • CT2 3 4
  • Cancer/Testis Antigen Family 6, Member 2a 3
  • Cancer/Testis Antigen Family 6, Member 2b 3
  • Cancer/Testis Antigen Family 6 2
  • Member 2a 2
  • Member 2b 2
  • LAGE2B 3
  • CT6.2a 3
  • CT6.2b 3

External Ids for CTAG2 Gene

Previous GeneCards Identifiers for CTAG2 Gene

  • GC0XM147943
  • GC0XM150260
  • GC0XM151465
  • GC0XM152347
  • GC0XM153443
  • GC0XM153533
  • GC0XM153880
  • GC0XM142426

Summaries for CTAG2 Gene

Entrez Gene Summary for CTAG2 Gene

  • This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID:10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for CTAG2 Gene

CTAG2 (Cancer/Testis Antigen 2) is a Protein Coding gene. Diseases associated with CTAG2 include melanoma and testicular germ cell tumor. An important paralog of this gene is CTAG1B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTAG2 Gene

Genomics for CTAG2 Gene

Regulatory Elements for CTAG2 Gene

Transcription factor binding sites by QIAGEN in the CTAG2 gene promoter:

Genomic Location for CTAG2 Gene

154,651,972 bp from pter
154,653,579 bp from pter
1,608 bases
Minus strand

Genomic View for CTAG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTAG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTAG2 Gene

Proteins for CTAG2 Gene

  • Protein details for CTAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cancer/testis antigen 2
    Protein Accession:
    Secondary Accessions:
    • O75637
    • Q0VIL6
    • Q14CD6
    • Q2Z1N4
    • Q9BU80
    • Q9UJ89
    • Q9Y479

    Protein attributes for CTAG2 Gene

    210 amino acids
    Molecular mass:
    21061 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CTAG2 Gene


neXtProt entry for CTAG2 Gene

Proteomics data for CTAG2 Gene at MOPED

Post-translational modifications for CTAG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTAG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CTAG2 Gene

Domains for CTAG2 Gene

Protein Domains for CTAG2 Gene


Suggested Antigen Peptide Sequences for CTAG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CTAG/PCC1 family.
  • Belongs to the CTAG/PCC1 family.
genes like me logo Genes that share domains with CTAG2: view

No data available for Gene Families for CTAG2 Gene

Function for CTAG2 Gene

Gene Ontology (GO) - Molecular Function for CTAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CTAG2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTAG2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CTAG2 Gene

Localization for CTAG2 Gene

Subcellular locations from

Jensen Localization Image for CTAG2 Gene COMPARTMENTS Subcellular localization image for CTAG2 gene
Compartment Confidence
cytoskeleton 4
cytosol 2
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CTAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with CTAG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CTAG2 Gene

Pathways for CTAG2 Gene

SuperPathways for CTAG2 Gene

No Data Available

Interacting Proteins for CTAG2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000247306 O75638-CTAG2_HUMAN for CTAG2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for CTAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with CTAG2: view

No data available for Pathways by source for CTAG2 Gene

Transcripts for CTAG2 Gene

mRNA/cDNA for CTAG2 Gene

Unigene Clusters for CTAG2 Gene

Cancer/testis antigen 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTAG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTAG2 Gene

ExUns: 1a · 1b ^ 2 ^ 3

Relevant External Links for CTAG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTAG2 Gene

mRNA expression in normal human tissues for CTAG2 Gene

mRNA differential expression in normal tissues according to GTEx for CTAG2 Gene

This gene is overexpressed in Testis (17.5).

Protein differential expression in normal tissues for CTAG2 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTAG2 Gene

SOURCE GeneReport for Unigene cluster for CTAG2 Gene Hs.87225

mRNA Expression by UniProt/SwissProt for CTAG2 Gene

Tissue specificity: Testis and very low level in placenta and in some uterus samples. Observed in 25-50% of tumor samples of melanomas, non-small-cell lung carcinomas, bladder, prostate and head and neck cancers
genes like me logo Genes that share expressions with CTAG2: view

Expression partners for CTAG2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CTAG2 Gene

Orthologs for CTAG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTAG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC465964 35
  • 98.52 (n)
  • 95.56 (a)
-- 36
  • 67 (a)
-- 36
  • 67 (a)
(Canis familiaris)
Mammalia -- 36
  • 24 (a)
(Mus musculus)
Mammalia Ctag2 36
  • 14 (a)
(Danio rerio)
Actinopterygii CABZ01063556.1 36
  • 23 (a)
Species with no ortholog for CTAG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTAG2 Gene

Gene Tree for CTAG2 (if available)
Gene Tree for CTAG2 (if available)

Paralogs for CTAG2 Gene

Paralogs for CTAG2 Gene

(2) SIMAP similar genes for CTAG2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CTAG2: view

Variants for CTAG2 Gene

Sequence variations from dbSNP and Humsavar for CTAG2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2075897 -- 154,651,907(-) GGTTG(C/T)AGGGG downstream-variant-500B
rs3829774 -- 154,654,435(-) ACACA(C/G)AAGTA upstream-variant-2KB
rs3829775 -- 154,654,432(-) CAGAA(A/G)TAAGC upstream-variant-2KB
rs3829776 -- 154,654,429(-) AAGTA(A/G)GCCAG upstream-variant-2KB
rs3829777 -- 154,654,428(-) AGTAA(A/G)CCAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CTAG2 Gene

Variant ID Type Subtype PubMed ID
esv33784 CNV Gain+Loss 17666407
nsv518228 CNV Gain 19592680

Relevant External Links for CTAG2 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTAG2 Gene

Disorders for CTAG2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CTAG2 Gene in MalaCards »

(4) Diseases for CTAG2 Gene

(6) Novoseek inferred disease relationships for CTAG2 Gene

Disease -log(P) Hits PubMed IDs
melanoma 47.4 15
cancer 46.4 9
tumors 40.8 18
esophageal carcinoma 39.2 3
nsclc 29.1 3

Relevant External Links for CTAG2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CTAG2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CTAG2 Gene

Publications for CTAG2 Gene

  1. Interleukin-2-induced, melanoma-specific T cells recognize CAMEL, an unexpected translation product of LAGE-1. (PMID: 10399963) Aarnoudse C.A. … Schrier P.I. (Int. J. Cancer 1999) 2 3 4 23
  2. Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients. (PMID: 17899192) Shao Y. … Zhao H.-T. (J. Cancer Res. Clin. Oncol. 2008) 3 4 23 48
  3. LAGE-1, a new gene with tumor specificity. (PMID: 9626360) Lethe B.G. … Boon T. (Int. J. Cancer 1998) 2 3 4
  4. Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes. (PMID: 11709543) Aradhya S. … Nelson D.L. (Hum. Mol. Genet. 2001) 3 4
  5. Prognostic impact of cancer/testis antigen expression in advanced stage multiple myeloma patients. (PMID: 18237105) Andrade V.C. … Colleoni G.W. (Cancer Immun. 2008) 3 23

Products for CTAG2 Gene

Sources for CTAG2 Gene

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