CTAG2 Gene
protein-coding GIFtS: 45
GCID: GC0XM153880
|
|
cancer/testis antigen 2
| |
Aliases
for CTAG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cancer/Testis Antigen 21 2 | | CT6.22 3 | | ESO21 2 3 | | LAGE-1a1 | | LAGE-11 2 3 | | LAGE-1b1 | | CAMEL1 2 | | MGC1387241 | | CT6.2a1 2 | | MGC38031 | | CT6.2b1 2 | | LAGE2B2 | | LAGE11 3 | | Cancer/Testis Antigen Family 6, Member 2a2 | | Autoimmunogenic Cancer/Testis Antigen NY-ESO-22 3 | | Cancer/Testis Antigen Family 6, Member 2b2 | | Cancer/Testis Antigen 6.22 3 | | CTL-Recognized Antigen On Melanoma2 | | L Antigen Family Member 12 3 | | LAGE-1a Protein2 | | CT22 3 | | |
Export aliases for CTAG2 gene to outside databasesPrevious GC identifers: GC0XM147943 GC0XM150260 GC0XM151465 GC0XM152347 GC0XM153443 GC0XM153533 GC0XM142426 |
Summaries
for CTAG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CTAG2:
This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. Thisprotein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer.This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene hasbeen described in PMID 10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized bymelanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. (provided byRefSeq, May 2010)
|
Genomic Views
for CTAG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CTAG2 gene promoter:
Sp1 ATF-2 c-Jun E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for CTAG2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTAG2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28CTAG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM153880: view genomic region
(about GC identifiers)
Start:
|
153,880,246 bp from pter |
End:
|
153,881,853 bp from pter |
Size:
|
1,608 bases |
Orientation:
|
minus strand |
|
Proteins
for CTAG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CTAG2_HUMAN, O75638 (See
protein sequence)Recommended Name: Cancer/testis antigen 2 Size: 210 amino acids; 21061 Da
Secondary accessions: O75637 Q0VIL6 Q14CD6 Q2Z1N4 Q9BU80 Q9UJ89 Q9Y479Alternative splicing: 2 isoforms: O75638-1 O75638-2 Explore the universe of human proteins at neXtProt for CTAG2: NX_O75638
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75638
CTAG2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_066274.1 NP_758965.1
ENSEMBL proteins: ENSP00000247306 ENSP00000358598
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005813 | centrosome |
IDA | -- |
CTAG2 for ontologies About GeneDecksing
CTAG2 Antibody Products:
Assay Products for CTAG2: |
Protein
Domains /
Families
for CTAG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CTAG2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O75638ProtoNet protein and cluster: O75638 UniProtKB/Swiss-Prot: CTAG2_HUMAN, O75638Similarity: Belongs to the CTAG family |
Function
for CTAG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTAG2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTAG2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CTAG2 (NM_172377) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTAG2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTAG2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
CTAG2 for ontologies About GeneDecksing
|
Pathways & Interactions
for CTAG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTAG2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for CTAG2 (ENSP000002473064) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
CTAG2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CTAG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CTAG2
Search CenterWatch for drugs/clinical trials and news about CTAG2
|
Transcripts
for CTAG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CTAG2 gene (2 alternative transcripts): NM_020994.3 NM_172377.3 Unigene Cluster for CTAG2: Cancer/testis antigen 2 Hs.87225 [show with all ESTs]Unigene Representative Sequence: AJ2230402 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000247306(uc004fmh.2 uc004fmi.2) ENST00000369585
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTAG2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTAG2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CTAG2 (NM_172377) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTAG2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTAG2 |
Additional cDNA sequence: AJ012833.1 AJ012834.1 AJ012835.1 AJ223040.1 AJ223041.1 AY679088.1 AY679089.1 BC002833.2 BC113998.1 BC114933.1 BC128045.1 2 DOTS entries: DT.100018675 DT.121283813 24/28 AceView cDNA sequences (see all 28): BX279602 AJ223040 BU629220 BM719406 NM_172377 NM_020994 AJ012835 AJ012833 AJ223041 BM684237 AJ012834 BI856831 BG575764 BI861547 BC002833 BM797218 CA424840 BE274123 BE410697 BE276194 BE410952 BE390259 BE391232 BE387918
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CTAG2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | |
ECgene alternative splicing isoforms for CTAG2
|
Expression
for CTAG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CTAG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CTAG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTAG2
SOURCE GeneReport for Unigene cluster: Hs.87225
UniProtKB/Swiss-Prot: CTAG2_HUMAN, O75638Tissue specificity: Testis and very low level in placenta and in some uterus samples. Observed in 25-50% of tumorsamples of melanomas, non-small-cell lung carcinomas, bladder, prostate and head and neck cancers
SABiosciences Custom PCR Arrays for CTAG2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTAG2
Browse OriGene validated miRNA SYBR primer pairs
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Orthologs
for CTAG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CTAG2 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01063556.16 |
-- |
24(a) |
1 → many |
10(44098873-44103318) |
Species with no ortholog for CTAG2
ENSEMBL Gene Tree for CTAG2 (if available)
TreeFam Gene Tree for CTAG2 (if available) |
Paralogs
for CTAG2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CTAG2 gene
- CTAG1A2 CTAG1B2 LAGE32
2 SIMAP similar genes for CTAG2 using alignment to 2 protein entries: CTAG2_HUMAN (see all proteins):CTAG1A CTAG1B
CTAG2 for paralogs About GeneDecksing
|
Genomic Variants
for CTAG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CTAG2 (153880246 - 153881853 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CTAG2: --
Locus Specific Mutation Databases (LSDB): CTAG2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTAG2 |
|
Disorders
/ Diseases
for CTAG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CTAG2 for disorders About GeneDecksing
OMIM gene information: 300396
OMIM disorders: --
20/25  diseases for CTAG2 (see all 25): About MalaCardsmelanoma prostate cancer non-small cell lung carcinoma prostatitis
testicular germ cell tumor germ cell tumor breast cancer cervical squamous cell carcinoma
squamous cell carcinoma epithelial ovarian cancer esophageal carcinoma multiple myeloma
ovarian cancer lung carcinoma carcinoma esophagitis
myeloma hepatocellular carcinoma cervicitis gastric cancer
6 Novoseek disease relationships for CTAG2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| melanoma |
47.4 |
22 |
19651643 (3), 11120859 (3), 12538712 (3), 15623618 (2) (see all 8) |
| cancer |
46.4 |
9 |
17899192 (3), 16187088 (2), 11531257 (1), 15623618 (1) (see all 6) |
| tumors |
40.8 |
23 |
16187088 (2), 12538712 (2), 14522938 (2), 10399963 (1) (see all 15) |
| esophageal carcinoma |
39.2 |
3 |
11531257 (2), 16438850 (1) |
| nsclc |
29.1 |
3 |
15061963 (1), 16353146 (1), 16299236 (1) |
| metastasis |
0 |
1 |
16091172 (1) |
Human Genome Epidemiology (HuGE) Navigator: CTAG2 (1 document)
Export disorders for CTAG2 gene to outside databases
|
Publications
for CTAG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CTAG2 gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with CTAG2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interleukin-2-induced, melanoma-specific T cells recognize CAMEL, an unexpected translation product of LAGE-1. (PubMed id 10399963)1, 2, 3, 9 Aarnoudse C.A....Schrier P.I. (1999)
- LAGE-1, a new gene with tumor specificity. (PubMed id 9626360)1, 2, 3 Lethe B.G.... Boon T. (1998)
- Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients. (PubMed id 17899192)1, 2, 9 Shao Y....Zhao H.-T. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes. (PubMed id 11709543)1, 2 Aradhya S....Nelson D.L. (2001)
- A new specific gene expression in squamous cell carcinoma of the esophagus detected using representational difference analysis and cDNA microarray. (PubMed id 16446548)1, 9 Kan T....Shimada Y. (2006)
- CD4+ Th2 cell recognition of HLA-DR-restricted epitopes derived from CAMEL: a tumor antigen translated in an alternative open reading frame. (PubMed id 12538712)1, 9 Slager E.H....Griffioen M. (2003)
- NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer. (PubMed id 14522938)1, 9 Odunsi K....Old L.J. (2003)
- Efficient simultaneous presentation of NY-ESO-1/LAGE-1 primary and nonprimary open reading frame-derived CTL epitopes in melanoma. (PubMed id 11120859)1, 9 Rimoldi D....Valmori D. (2000)
- Identification of multiple HLA-DR-restricted epitopes of the tumor-associated antigen CAMEL by CD4+ Th1/Th2 lymphocytes. (PubMed id 15067093)1, 9 Slager E.H....Osanto S. (2004)
|
External Searches for CTAG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CTAG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CTAG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CTAG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CTAG2 gene:
Search GeneIP for patents involving CTAG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CTAG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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