CTAG1A Gene
protein-coding GIFtS: 47
GCID: GC0XP153813
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cancer/testis antigen 1A
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Aliases
for CTAG1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cancer/Testis Antigen 1A1 2 | | LAGE-22 3 | | ESO11 2 3 | | Cancer/Testis Antigen 12 | | LAGE2A1 2 3 | | Cancer/Testis Antigen 1-A2 | | Autoimmunogenic Cancer/Testis Antigen NY-ESO-12 3 | | CTAG3 | | Cancer/Testis Antigen 6.12 3 | | CTAG13 | | L Antigen Family Member 22 3 | | LAGE23 | | CT6.12 3 | | LAGE2B3 |
Export aliases for CTAG1A gene to outside databasesPrevious GC identifers: GC0XP152283 GC0XM153409 GC0XM153500 GC0XP153467 |
Summaries
for CTAG1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CTAG1A:
CTAG1A is an identical copy of the CTAG1B gene (MIM 300156) (Aradhya et al., 2001 (PubMed 11709543)).(supplied by OMIM,Mar 2008)
|
Genomic Views
for CTAG1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CTAG1A gene promoter:
Bach1 TBP MIF-1 CUTL1 Evi-1 RORalpha2 C/EBPalpha HSF2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for CTAG1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTAG1A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28CTAG1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP153813: view genomic region
(about GC identifiers)
Start:
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153,813,407 bp from pter |
End:
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153,815,075 bp from pter |
Size:
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1,669 bases |
Orientation:
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plus strand |
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Proteins
for CTAG1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CTG1B_HUMAN, P78358 (See
protein sequence)Recommended Name: Cancer/testis antigen 1 Size: 180 amino acids; 17992 Da
Subcellular location: Cytoplasm
6/8 PDB 3D structures from  and Proteopedia  for CTAG1A (see all 8):2BNQ (3D)
2BNR (3D)
2F53 (3D)
2F54 (3D)
2P5E (3D)
2P5W (3D)
Secondary accessions: A1L417 B7WNL9 Q7LBY4 Q9NY13Alternative splicing: 2 isoforms: P78358-1 P78358-2 Explore the universe of human proteins at neXtProt for CTAG1A: NX_P78358
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P78358
CTAG1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_640343.1
ENSEMBL proteins: ENSP00000399822 ENSP00000332018
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IDA | -- |
CTAG1A for ontologies About GeneDecksing
CTAG1A Antibody Products:
Assay Products for CTAG1A: |
Protein
Domains /
Families
for CTAG1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CTAG1A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P78358ProtoNet protein and cluster: P78358 UniProtKB/Swiss-Prot: CTG1B_HUMAN, P78358Similarity: Belongs to the CTAG family |
Function
for CTAG1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTAG1A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTAG1A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: CTAG1A (NM_139250) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTAG1A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTAG1A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
CTAG1A for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CTAG1A:
|
Pathways & Interactions
for CTAG1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Meiosis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CTAG1A
CTAG1A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTAG1A
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/7 Interacting proteins for CTAG1A (P783581, 3 ENSP000003320184) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
|
Drugs & Compounds
for CTAG1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CTAG1A
Search CenterWatch for drugs/clinical trials and news about CTAG1A / CTG1B
|
Transcripts
for CTAG1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CTAG1A gene: NM_139250.1 Unigene Clusters for CTAG1A: Cancer/testis antigen 1A Hs.534310 , Hs.741688 [show with all ESTs]Unigene Representative Sequences: AJ275978, NM_1392502 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000443287(uc004fme.3) ENST00000333128
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTAG1A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTAG1A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CTAG1A (NM_139250) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTAG1A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTAG1A |
1 DOTS entry: DT.104006 12 AceView cDNA sequences: NM_139250 AA634317 AJ003149 AJ275978 CR594675 BQ575599 U87459 AL553954 AF038567 NM_001327 AI218223 AL553953
GeneLoc Exon Structure
|
Expression
for CTAG1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CTAG1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CTAG1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTAG1A
SOURCE GeneReport for Unigene clusters: Hs.534310 Hs.741688
UniProtKB/Swiss-Prot: CTG1B_HUMAN, P78358Tissue specificity: Expressed in testis and ovary and in a wide variety of cancers. Detected in uterine myometrium.Expressed from 18 weeks until birth in human fetal testis. In the adult testis, is strongly expressed in spermatogoniaand in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells (at protein level)
SABiosciences Custom PCR Arrays for CTAG1A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTAG1A
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CTAG1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTAG1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTAG1A |
Orthologs
for CTAG1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CTAG1A gene from 1/3 species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01063556.16 |
-- |
38(a) |
1 → many |
10(44098873-44103318) |
ENSEMBL Gene Tree for CTAG1A (if available)
TreeFam Gene Tree for CTAG1A (if available) |
Paralogs
for CTAG1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CTAG1A gene
- CTAG1B1 2 CTAG22 LAGE32
2 SIMAP similar genes for CTAG1A using alignment to 1 protein entry: CTG1B_HUMAN:CTAG2 LAGE3
CTAG1A for paralogs About GeneDecksing
|
Genomic Variants
for CTAG1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CTAG1A (153813407 - 153815075 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CTAG1A
2 Indels: 74089 74088
1 Inversion: 37366 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTAG1A |
|
Disorders
/ Diseases
for CTAG1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CTAG1A for disorders About GeneDecksing
OMIM gene information: 300657
OMIM disorders: --
10  diseases for CTAG1A: About MalaCardsalveolar soft part sarcoma non-small cell lung carcinoma seminoma lung carcinoma
sarcoma carcinoma melanoma esophageal squamous cell carcinoma
squamous cell carcinoma esophagitis
Export disorders for CTAG1A gene to outside databases
|
Publications
for CTAG1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CTAG1A gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with CTAG1A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes. (PubMed id 11709543)1, 2, 3 Aradhya S....Nelson D.L. (2001)
- DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. (PubMed id 10523621)1, 2, 3 De Smet C....Boon T. (1999)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ. (PubMed id 12065688)1, 2 Satie A.P.... Samson M. (2002)
- A breast and melanoma-shared tumor antigen: T cell responses to antigenic peptides translated from different open reading frames. (PubMed id 9759882)1, 2 Wang R.-F.... Rosenberg S.A. (1998)
- LAGE-1, a new gene with tumor specificity. (PubMed id 9626360)1, 2 Lethe B.G.... Boon T. (1998)
- A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. (PubMed id 9050879)1, 2 Chen Y.-T.... Old L.J. (1997)
- Physical interaction of two cancer-testis antigens, MAGE-C1 (CT7) and NY-ESO-1 (CT6). (PubMed id 17137291)1 Cho H.J....Simpson A.J. (2006)
- Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance. (PubMed id 16596224)1 Yoshida N....Nishimura T. (2006)
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External Searches for CTAG1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CTAG1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CTAG1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CTAG1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CTAG1A gene:
Search GeneIP for patents involving CTAG1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CTAG1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTAG1A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTAG1A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTAG1A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTAG1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTAG1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTAG1A |
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| |  |  |  |  | | | | | | Recombinant Protein for CTAG1A |
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 | | | CTAG1A Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for CTAG1A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTAG1A |
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