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Aliases for CTAG1A Gene

Aliases for CTAG1A Gene

  • Cancer/Testis Antigen 1A 2 3 5
  • Autoimmunogenic Cancer/Testis Antigen NY-ESO-1 3 4
  • Cancer/Testis Antigen 6.1 3 4
  • L Antigen Family Member 2 3 4
  • LAGE-2 3 4
  • LAGE2A 3 4
  • CT6.1 3 4
  • ESO1 3 4
  • New York Esophageal Squamous Cell Carcinoma 1 3
  • Cancer/Testis Antigen 1-A 3
  • Cancer/Testis Antigen 1 3
  • CTAG1A CTAG1B 4
  • NY-ESO-1 3
  • LAGE2B 4
  • CTAG1 4
  • LAGE2 4
  • CTAG 4

External Ids for CTAG1A Gene

Previous GeneCards Identifiers for CTAG1A Gene

  • GC0XP152283
  • GC0XM153409
  • GC0XM153500
  • GC0XP153467
  • GC0XP153813

Summaries for CTAG1A Gene

Entrez Gene Summary for CTAG1A Gene

  • The protein encoded by this gene is a tumor cell antigen found in various types of cancers, which makes it a good candidate for a cancer vaccine. This gene is also highly expressed in normal ovary and testis tissues. An identical copy of this gene is found on the same chromosome. [provided by RefSeq, Dec 2015]

GeneCards Summary for CTAG1A Gene

CTAG1A (Cancer/Testis Antigen 1A) is a Protein Coding gene. An important paralog of this gene is CTAG1B.

Additional gene information for CTAG1A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTAG1A Gene

Genomics for CTAG1A Gene

Regulatory Elements for CTAG1A Gene

Enhancers for CTAG1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH154599 1 Ensembl ENCODE 0.4 +15.7 15745 1 TBP MXI1 ZSCAN26 ZNF473 JUN FOSL1 POLR2A FOS TCF7L2 SMARCC1 FAM3A GAB3 MECP2 EMD PLXNA3 HCFC1 ENSG00000232155 CTAG1A
GH0XH154595 0.9 Ensembl ENCODE 0.4 +11.4 11434 1 CTCF MAX CEBPB FEZF1 SALL2 RAD21 EP300 JUND SMC3 POU5F1 LOC105373383 GDI1 GAB3 PDZD4 L1CAM FAM3A ENSG00000232155 CTAG1A
GH0XH154603 0.7 ENCODE 0.4 +19.0 18982 1 TBP JUN MAX RAD21 SCRT2 SMC3 RCOR1 FOS DEK ZNF10 FAM3A ENSG00000232155 CTAG1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CTAG1A on UCSC Golden Path with GeneCards custom track

Genomic Location for CTAG1A Gene

Chromosome:
X
Start:
154,585,143 bp from pter
End:
154,586,821 bp from pter
Size:
1,679 bases
Orientation:
Plus strand

Genomic View for CTAG1A Gene

Genes around CTAG1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTAG1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTAG1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTAG1A Gene

Proteins for CTAG1A Gene

  • Protein details for CTAG1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78358-CTG1B_HUMAN
    Recommended name:
    Cancer/testis antigen 1
    Protein Accession:
    P78358
    Secondary Accessions:
    • A1L417
    • B7WNL9
    • Q7LBY4
    • Q9NY13

    Protein attributes for CTAG1A Gene

    Size:
    180 amino acids
    Molecular mass:
    17992 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTAG1A Gene

    Alternative splice isoforms for CTAG1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTAG1A Gene

Post-translational modifications for CTAG1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTAG1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTAG1A Gene

Domains & Families for CTAG1A Gene

Gene Families for CTAG1A Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CTAG1A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P78358

UniProtKB/Swiss-Prot:

CTG1B_HUMAN :
  • Belongs to the CTAG/PCC1 family.
Family:
  • Belongs to the CTAG/PCC1 family.
genes like me logo Genes that share domains with CTAG1A: view

No data available for Suggested Antigen Peptide Sequences for CTAG1A Gene

Function for CTAG1A Gene

Gene Ontology (GO) - Molecular Function for CTAG1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17137291
genes like me logo Genes that share ontologies with CTAG1A: view

Phenotypes for CTAG1A Gene

genes like me logo Genes that share phenotypes with CTAG1A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CTAG1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTAG1A Gene

Localization for CTAG1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTAG1A Gene

Gene Ontology (GO) - Cellular Components for CTAG1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CTAG1A: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for CTAG1A Gene

Pathways & Interactions for CTAG1A Gene

No data available for Pathways by source and SIGNOR curated interactions for CTAG1A Gene

Drugs & Compounds for CTAG1A Gene

No Compound Related Data Available

Transcripts for CTAG1A Gene

mRNA/cDNA for CTAG1A Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTAG1A Gene

Cancer/testis antigen 1A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CTAG1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CTAG1A Gene

No ASD Table

Relevant External Links for CTAG1A Gene

GeneLoc Exon Structure for
CTAG1A
ECgene alternative splicing isoforms for
CTAG1A

Expression for CTAG1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTAG1A Gene

Protein differential expression in normal tissues from HIPED for CTAG1A Gene

This gene is overexpressed in Bone (43.6), Liver, secretome (12.1), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTAG1A Gene



Protein tissue co-expression partners for CTAG1A Gene

NURSA nuclear receptor signaling pathways regulating expression of CTAG1A Gene:

CTAG1A

SOURCE GeneReport for Unigene cluster for CTAG1A Gene:

Hs.534310

mRNA Expression by UniProt/SwissProt for CTAG1A Gene:

P78358-CTG1B_HUMAN
Tissue specificity: Expressed in testis and ovary and in a wide variety of cancers. Detected in uterine myometrium. Expressed from 18 weeks until birth in human fetal testis. In the adult testis, is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells (at protein level).
genes like me logo Genes that share expression patterns with CTAG1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTAG1A Gene

Orthologs for CTAG1A Gene

Evolution for CTAG1A Gene

ENSEMBL:
Gene Tree for CTAG1A (if available)
TreeFam:
Gene Tree for CTAG1A (if available)

No data available for Orthologs for CTAG1A Gene

Paralogs for CTAG1A Gene

Paralogs for CTAG1A Gene

(2) SIMAP similar genes for CTAG1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTAG1A: view

Variants for CTAG1A Gene

Sequence variations from dbSNP and Humsavar for CTAG1A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs112926777 -- 154,583,392(+) TGTCT(C/T)CCTGC upstream-variant-2KB
rs200099747 -- 154,586,534(+) ACTGA(C/T)TGCTG reference, missense
rs200533109 -- 154,586,183(+) CCATG(A/G)AAGCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CTAG1A Gene

Variant ID Type Subtype PubMed ID
esv27930 CNV gain 19812545
esv29893 CNV gain 19812545
esv33199 CNV gain+loss 17666407
esv3369299 OTHER inversion 20981092
esv33784 CNV gain+loss 17666407
esv3577563 CNV gain 25503493
nsv1075747 CNV deletion 25765185
nsv1075748 CNV deletion 25765185
nsv1144327 CNV deletion 24896259
nsv508816 CNV insertion 20534489
nsv518228 CNV gain 19592680
nsv519042 CNV gain 19592680
nsv7469 OTHER inversion 18451855

Relevant External Links for CTAG1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTAG1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CTAG1A Gene

Disorders for CTAG1A Gene

Relevant External Links for CTAG1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTAG1A

No disorders were found for CTAG1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTAG1A Gene

Publications for CTAG1A Gene

  1. Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes. (PMID: 11709543) Aradhya S … Nelson DL (Human molecular genetics 2001) 2 3 4 60
  2. DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. (PMID: 10523621) De Smet C … Boon T (Molecular and cellular biology 1999) 2 3 4 60
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ. (PMID: 12065688) Satie AP … Samson M (Laboratory investigation; a journal of technical methods and pathology 2002) 3 4 60

Products for CTAG1A Gene

Sources for CTAG1A Gene

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