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Aliases &
Descriptions
for CTAG1B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| CT6.1 3 | | CTAG 2, 3 | | CTAG1 2, 3, 5 | | ESO1 1, 2, 3 | | LAGE-2 2, 3 | | LAGE2 3 | | LAGE2A 1, 3 | | LAGE2B 1, 2, 3 | | NY-ESO-1 1, 2 | | OTTHUMP00000026025 2 | | OTTHUMP00000026042 2 |
| | | Descriptions |
|---|
| Autoimmunogenic cancer/testis antigen NY-ESO-1 3 | | Cancer/testis antigen 6.1 3 | | L antigen family member 2 3 | | New York esophageal squamous cell carcinoma 1 2 | | cancer antigen 3 2 | | cancer/testis antigen 1 1 | | cancer/testis antigen 1B 2 |
|
| |
Search outside databases for aliases for CTAG1B genePrevious GC identifers: GC0XP152282 GC0XM153410 |
Summaries
for CTAG1B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CTAG1B:
Cancer/testis antigens, such as CTAG1B, are expressed in a variety of malignant tumors but soley in
testis among normal adult tissues (Yoshida et al., 2006 [PubMed 16596224]).[supplied by OMIM]
Gene Wiki entry for CTAG1B |
Genomic Location
for CTAG1B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the CTAG1B gene 
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28CTAG1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM153499:
(about GC identifiers)
Start:
|
153,499,059 bp from pter |
End:
|
153,500,727 bp from pter |
Size:
|
1,669 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011726.13
| Proteins
for CTAG1B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CTG1B_HUMAN, P78358 (See
protein sequence)Recommended Name: Cancer/testis antigen 1 Size: 180 amino acids; 17992 Da
Subcellular location: Cytoplasm
PDB structures from  and Proteopedia  :2BNR (3D)
2F53 (3D)
2F54 (3D)
2P5E (3D)
2P5W (3D)
2PYE (3D)
Secondary accessions: A1L417 Q7LBY4 Q9NY13Alternative splicing: 2 isoforms: P78358-1 P78358-2 REFSEQ proteins: NP_001318.1
ENSEMBL proteins: ENSP00000332602 ENSP00000352953
Human Recombinant Proteins  OriGene Purified Recombinant Human Protein: CTAG1B
Antibodies for CTAG1B:
Assays for CTAG1B: | Protein
Domains/
Families
for CTAG1B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P78358
ProtoNet protein and cluster: P78358 UniProtKB/Swiss-Prot: CTG1B_HUMAN, P78358Similarity: Belongs to the CTAG family | Gene Function
for CTAG1B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001327
 Applied Biosystems Silencer® siRNAs for CTAG1B
 Sigma-Aldrich siRNA for CTAG1B
Sigma-Aldrich shRNA for CTAG1B
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_001327
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001327
untagged cDNA clone in CMV expression vector: NM_001327
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_001327
| Pathways & Interactions
for CTAG1B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for CTAG1B
1 Interacting protein for CTAG1B (P783581) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds
for CTAG1B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CTAG1B
1  Novoseek chemical compound relationship for CTAG1B gene
About this table
|
Transcripts
for CTAG1B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001327
Sigma-Aldrich siRNA for CTAG1B
Sigma-Aldrich shRNA for CTAG1B
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_001327 REFSEQ mRNAs for CTAG1B gene: NM_001327.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001327
OriGene GFP tagged cDNA clone in CMV expression vector: NM_001327
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001327
untagged cDNA clone in CMV expression vector: NM_001327
Additional cDNA sequence: AF038567.1 AJ003149.1 AJ275978.1 BC130362.1 BC130364.1 U87459.1 1 DOTS entry: DT.104006 12 AceView cDNA sequences:AJ275978 BQ575599 NM_139250 AJ003149 AA634317 CR594675 AL553954 U87459 NM_001327 AF038567 AI218223 AL553953
 highest scoring ESTs for CTAG1B:U87459 AF038567 BC130362 BC130364 AJ003149 AJ275978 NM_001327 Unigene Cluster for CTAG1B: Cancer/testis antigen 1B Hs.534310 Unigene Representative Sequence: AJ275978
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000328435
ENST00000359887
|
Expression
for CTAG1B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CTAG1B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CTAG1B
1 / 2 / 3 8 probe-sets matching CTAG1B gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.534310
UniProtKB/Swiss-Prot: CTG1B_HUMAN, P78358Tissue specificity: Expressed in testis and ovary and in a wide variety of cancers. Detected in
uterine myometrium. Expressed from 18 weeks until birth in human fetal testis. In the adult
testis, is strongly expressed in spermatogonia and in primary spermatocytes, but not in
post-meiotic cells or in testicular somatic cells (at protein level) |
Orthologs
for CTAG1B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for CTAG1B | Paralogs
for CTAG1B(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CTAG1B gene
- CTAG1A1 2 CTAG21 2 LAGE32
|
SNPs/Variants
for CTAG1B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations
for CTAG1B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300156
10/38 Novoseek disease relationships for CTAG1B gene (see all 38
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| testicular cancer |
90.91 |
46 |
18982744 (2), 18396787 (2), 16432832 (2), 17625806 (2) (see all 41) |
| melanoma |
70.68 |
64 |
11397121 (5), 9547346 (3), 15623618 (3), 11259659 (2) (see all 39) |
| cancer |
68.33 |
118 |
12853579 (5), 17278093 (5), 11265773 (4), 15994128 (4) (see all 68) |
| tumors |
64.50 |
223 |
10502728 (8), 11406534 (6), 11351307 (4), 15026363 (4) (see all 91) |
| metastatic melanoma |
63.06 |
7 |
15534491 (2), 9547346 (1), 15867394 (1) |
| uterine neoplasms |
61.35 |
1 |
14695148 (1) |
| sarcoma synovial |
44.39 |
5 |
11668506 (3), 15683221 (1) |
| ovarian cancer |
41.10 |
6 |
16105096 (1), 16365599 (1), 9547346 (1), 18519754 (1) (see all 6) |
| hepatocellular carcinoma |
38.44 |
38 |
16872310 (9), 16091172 (2), 19212631 (2), 17637219 (2) (see all 11) |
| esophageal carcinoma |
38.18 |
16 |
12452034 (7), 15118836 (2), 11531257 (1), 16438850 (1) (see all 5) |
About this table
|
Medical News
for CTAG1B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CTAG1B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/216 PubMed articles for CTAG1B gene (see all 216
):- Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes. (PubMed id 11709543)2, 3, 4 Aradhya S....Nelson D.L. (2001)
- Genomic cloning and localization of CTAG, a gene encoding an autoimmunogenic cancer-testis antigen NY-ESO-1, to human chromosome Xq28. (PubMed id 9605863)1, 2, 3 Chen Y.T....Arden K.C. (1997)
- A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. (PubMed id 9050879)1, 3, 4 Chen Y.-T.... Old L.J. (1997)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)3, 4 Ross M.T.... Bentley D.R. (2005)
- The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ. (PubMed id 12065688)3, 4 Satie A.P.... Samson M. (2002)
- DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. (PubMed id 10523621)3, 4 De Smet C....Boon T. (1999)
- A breast and melanoma-shared tumor antigen: T cell responses to antigenic peptides translated from different open reading frames. (PubMed id 9759882)3, 4 Wang R.-F.... Rosenberg S.A. (1998)
- LAGE-1, a new gene with tumor specificity. (PubMed id 9626360)3, 4 Lethe B.G.... Boon T. (1998)
- NY-ESO-1 expression and immunogenicity in malignant and benign breast tumors. (PubMed id 15026363)1, 3 Sugita Y....Monden M. (2004)
- Expression of the cancer/testis antigen NY-ESO-1 in primary and metastatic malignant melanoma (MM)--correlation with prognostic factors. (PubMed id 17625806)1, 3 Velazquez E.F....Bhardwaj N. (2007)
|
Search for CTAG1B
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CTAG1B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CTAG1B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CTAG1B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for CTAG1B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for CTAG1B:
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