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Aliases for CT83 Gene

Aliases for CT83 Gene

  • Cancer/Testis Antigen 83 2 3 4
  • CXorf61 3 4
  • KK-LC-1 3 4
  • KKLC1 3 4
  • Chromosome X Open Reading Frame 61 2
  • Kita-Kyushu Lung Cancer Antigen 1 2

External Ids for CT83 Gene

Previous HGNC Symbols for CT83 Gene

  • CXorf61

Previous GeneCards Identifiers for CT83 Gene

  • GC0XM115593

Summaries for CT83 Gene

GeneCards Summary for CT83 Gene

CT83 (Cancer/Testis Antigen 83) is a Protein Coding gene. Diseases associated with CT83 include lung cancer.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CT83 Gene

Genomics for CT83 Gene

Genomic Location for CT83 Gene

Chromosome:
X
Start:
116,461,682 bp from pter
End:
116,463,033 bp from pter
Size:
1,352 bases
Orientation:
Minus strand

Genomic View for CT83 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CT83 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CT83 Gene

No data available for Regulatory Elements for CT83 Gene

Proteins for CT83 Gene

  • Protein details for CT83 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H943-KKLC1_HUMAN
    Recommended name:
    Kita-kyushu lung cancer antigen 1
    Protein Accession:
    Q5H943

    Protein attributes for CT83 Gene

    Size:
    113 amino acids
    Molecular mass:
    12784 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CT83 Gene

Proteomics data for CT83 Gene at MOPED

Post-translational modifications for CT83 Gene

  • Glycosylation at Asn 83
  • Modification sites at PhosphoSitePlus

Other Protein References for CT83 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CT83 Gene

Domains & Families for CT83 Gene

Protein Domains for CT83 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CT83 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CT83: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CT83 Gene

Function for CT83 Gene

Phenotypes for CT83 Gene

GenomeRNAi human phenotypes for CT83:
genes like me logo Genes that share phenotypes with CT83: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CT83

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CT83 Gene

Localization for CT83 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CT83 Gene

Cell membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for CT83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CT83: view

No data available for Subcellular locations from COMPARTMENTS for CT83 Gene

Pathways & Interactions for CT83 Gene

SuperPathways for CT83 Gene

No Data Available

Interacting Proteins for CT83 Gene

Gene Ontology (GO) - Biological Process for CT83 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CT83 Gene

Drugs & Compounds for CT83 Gene

No Compound Related Data Available

Transcripts for CT83 Gene

mRNA/cDNA for CT83 Gene

(1) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CT83

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CT83 Gene

No ASD Table

Relevant External Links for CT83 Gene

GeneLoc Exon Structure for
CT83
ECgene alternative splicing isoforms for
CT83

Expression for CT83 Gene

mRNA expression in normal human tissues for CT83 Gene

mRNA differential expression in normal tissues according to GTEx for CT83 Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for CT83 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CT83 Gene



mRNA Expression by UniProt/SwissProt for CT83 Gene

Q5H943-KKLC1_HUMAN
Tissue specificity: Specifically expressed in testis. Expressed by cancer cell lines.
genes like me logo Genes that share expression patterns with CT83: view

Protein tissue co-expression partners for CT83 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CT83 Gene

Orthologs for CT83 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CT83 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100138847 35
  • 78.87 (n)
  • 65.18 (a)
dog
(Canis familiaris)
Mammalia CXHXorf61 35
  • 81.73 (n)
  • 64.42 (a)
CT83 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC742693 35
  • 99.71 (n)
  • 100 (a)
CT83 36
  • 100 (a)
OneToOne
Species with no ortholog for CT83:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CT83 Gene

ENSEMBL:
Gene Tree for CT83 (if available)
TreeFam:
Gene Tree for CT83 (if available)

Paralogs for CT83 Gene

Pseudogenes.org Pseudogenes for CT83 Gene

genes like me logo Genes that share paralogs with CT83: view

No data available for Paralogs for CT83 Gene

Variants for CT83 Gene

Sequence variations from dbSNP and Humsavar for CT83 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs6608510 -- 116,464,302(+) GGAAG(A/G)GGAGA upstream-variant-2KB
rs6608649 -- 116,462,427(+) GTGGG(A/G)GAGGA intron-variant
rs6608650 -- 116,463,791(+) tacta(C/T)gtgtc upstream-variant-2KB
rs12845014 -- 116,464,846(+) TGAAG(A/C)CAAAT upstream-variant-2KB
rs35371836 -- 116,462,447(+) AGAGA(-/AAGA)AGAGA intron-variant

Variation tolerance for CT83 Gene

Residual Variation Intolerance Score: 60.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CT83 Gene

HapMap Linkage Disequilibrium report
CT83

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CT83 Gene

Disorders for CT83 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CT83 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
- elite association
Search CT83 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CT83

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CT83
genes like me logo Genes that share disorders with CT83: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CT83 Gene

Publications for CT83 Gene

  1. Identification of a new cancer/germline gene, KK-LC-1, encoding an antigen recognized by autologous CTL induced on human lung adenocarcinoma. (PMID: 16651449) Fukuyama T. … Yasumoto K. (Cancer Res. 2006) 2 67
  2. Frequent High Expression of Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1) in Gastric Cancer. (PMID: 26026129) Shida A. … Watanabe M. (Anticancer Res. 2015) 67
  3. CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer. (PMID: 26327325) Paret C. … Sahin U. (Oncotarget 2015) 67
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 67
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 67

Products for CT83 Gene

Sources for CT83 Gene

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