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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CT62 Gene

protein-coding   GIFtS: 28
GCID: GC15M071402

Cancer/Testis Antigen 62

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cancer/Testis Antigen 621 2

External Ids:    HGNC: 272861   Entrez Gene: 1969932   Ensembl: ENSG000002253627   UniProtKB: P0C5K73   

Export aliases for CT62 gene to outside databases

Previous GC identifers: GC15M069190 GC15M048238


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CT62 Gene: 
CT62 (cancer/testis antigen 62) is a protein-coding gene. Diseases associated with CT62 include polycythemia.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CT62
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CT62

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CT62


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q23

CT62 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CT62 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M071402:  view genomic region     (about GC identifiers)

Start:
71,402,583 bp from pter      End:
71,407,839 bp from pter
Size:
5,257 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CT62_HUMAN, P0C5K7 (See protein sequence)
Recommended Name: Cancer/testis antigen 62  
Size: 136 amino acids; 15412 Da

Explore the universe of human proteins at neXtProt for CT62: NX_P0C5K7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0C5K7

  • CT62 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001096128.1  
    ENSEMBL proteins: 
     ENSP00000456091   ENSP00000399356   ENSP00000455569  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: P0C5K7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CT62

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CT62

    Search CenterWatch for drugs/clinical trials and news about CT62

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for CT62 gene: 
    NM_001102658.1  

    Unigene Cluster for CT62:

    Cancer/testis antigen 62
    Hs.646533  [show with all ESTs]
    Unigene Representative Sequence: NM_001102658
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566432 ENST00000449977(uc002ata.2) ENST00000567117
    miRNA
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    Additional mRNA sequence: 

    BC039359.1 BC048128.1 

    3 DOTS entries:

    DT.408337  DT.100748827  DT.40119164 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CT62 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CT62 Expression
    About this image


    Genevestigator expression for CT62

    SOURCE GeneReport for Unigene cluster: Hs.646533

    UniProtKB/Swiss-Prot: CT62_HUMAN, P0C5K7
    Tissue specificity: Testis specific. Expressed in cancer cell lines

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for CT62 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia CT626
    PREDICTED: Pan troglodytes cancer/testis antigen 6...
    99(a)
    1 ↔ 1
    15(68663565-68668816)


    ENSEMBL Gene Tree for CT62 (if available)
    TreeFam Gene Tree for CT62 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/122 SNPs in CT62 are shown (see all 122)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887794591,2
    --71402124(+) GTCTGG/TTGAGC 1 -- int10--------
    rs1815416121,2
    --71402135(+) CGCTAC/TAACTA 1 -- int10--------
    rs169551521,2
    C,F,H--71402221(+) GAGACC/GGTGTG 1 -- int17Minor allele frequency- G:0.01NA NS EA 558
    rs1862481081,2
    --71402251(+) CCTGGC/TTTTAT 1 -- int10--------
    rs1385291951,2
    C--71402255(+) GTTTTA/CTACAT 1 -- int10--------
    rs1153291311,2
    F--71402340(+) AAAGCC/TGGTTT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1919502271,2
    --71402596(+) GAATGA/GTGGAT 1 -- ut310--------
    rs10523021,2
    C,F,H--71402849(-) ATTGAG/AAAAGG 1 -- ut315Minor allele frequency- A:0.01NS EA NA 530
    rs13436981,2
    C,F,A,H--71403023(-) TCAGAG/ATCCAC 1 -- ut3119Minor allele frequency- A:0.24NS MN EA NA WA CSA 1182
    rs1422033831,2
    --71403082(+) TCTTTA/GCAAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CT62 (71402583 - 71407839 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CT62: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CT62
    DNA2.0 Custom Variant and Variant Library Synthesis for CT62

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CT62:    About MalaCards
    polycythemia    


    CT62 for disorders           About GeneDecksing


    Export disorders for CT62 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CT62 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CT62)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PubMed id 15905330)1, 2, 3 Chen Y.-T.... Simpson A.J.G. (2005)
    2. Genome-wide association analyses suggest NELL1 influen ces adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (2013)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 196993 HGNC: 27286 Ensembl:ENSG00000225362 euGenes: HUgn196993 ECgene: CT62
    H-InvDB: CT62

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CT62 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CT62 gene:
    Search GeneIP for patents involving CT62

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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