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CT45A6 Gene

protein-coding   GIFtS: 29
GCID: GC0XM134961

Cancer/Testis Antigen Family 45, Member A6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cancer/Testis Antigen Family 45, Member A61 2     CT45-62 3
Cancer/Testis Antigen CT45-61 2     CT45.62 5
Cancer/Testis Antigen 45-4/62 3     Cancer/Testis Antigen Family 45 Member A4/A62
Cancer/Testis Antigen 45A4/45A62 3     CT45-43

External Ids:    HGNC: 332711   Entrez Gene: 5414652   Ensembl: ENSG000002269077   OMIM: 3007975   UniProtKB: Q8N7B73   

Export aliases for CT45A6 gene to outside databases

Previous GC identifer: GC0XM134790


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CT45A6 Gene:
CT45A6 (cancer/testis antigen family 45, member A6) is a protein-coding gene. An important paralog of this gene is CT45A4.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CT45A6 gene promoter:
         AhR   N-Myc   PPAR-gamma1   PPAR-gamma2   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCT45A6 promoter sequence
   Search Chromatin IP Primers for CT45A6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CT45A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26.3

CT45A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CT45A6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM134961:  view genomic region     (about GC identifiers)

Start:
134,962,849 bp from pter      End:
134,971,244 bp from pter
Size:
8,396 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CT454_HUMAN, Q8N7B7 (See protein sequence)
Recommended Name: Cancer/testis antigen family 45 member A4/A6  
Size: 189 amino acids; 21245 Da

Explore the universe of human proteins at neXtProt for CT45A6: NX_Q8N7B7

Explore proteomics data for CT45A6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CT45A6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001017438.1  
    ENSEMBL proteins: 
     ENSP00000427362   ENSP00000388119   ENSP00000422541  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8N7B7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CT45A6

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    extracellular1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CT45A6
    Interactions:

        Search GeneGlobe Interaction Network for CT45A6

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CT45A6 (CT454)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CT45A6 gene: 
    NM_001017438.1  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491002 ENST00000448053(uc004ezf.3) ENST00000472834
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CT45A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CT45A6 Expression
    About this image

    CT45A6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CT45A6 Protein Expression

    UniProtKB/Swiss-Prot: CT454_HUMAN, Q8N7B7
    Tissue specificity: Testis specific. Expressed in cancer cell lines

        Custom PCR Arrays for CT45A6
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CT45A6 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    Uncharacterized protein
    26(a)
    1 → many
    X(106183890-106201175)
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    8(a)
    1 → many
    4(4111910-4145007)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    6(a)
    1 → many
    GL343761.1(61201-94435)
    zebrafish
    (Danio rerio)
    Actinopterygii ddx26b6
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
    5(a)
    1 → many
    14(32436381-32478038) ENSDARG00000017931
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS66
    Integrator 6
    3(a)
    1 → many
    X(5632696-5641287)
    worm
    (Caenorhabditis elegans)
    Secernentea dic-16
    Protein DIC-1, isoform b
    4(a)
    1 → many
    IV(8692099-8696456) WBGene00000994


    ENSEMBL Gene Tree for CT45A6 (if available)
    TreeFam Gene Tree for CT45A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CT45A6 gene
    CT45A21 2  CT45A11 2  CT45A31 2  LOC102723680  LOC102723737  LOC101060211  CT45A42  INTS62  
    CT45A52  SAGE12  DDX26B2  
    6 SIMAP similar genes for CT45A6 using alignment to 1 protein entry:     CT454_HUMAN:
    CT45A1    CT45A2    CT45A3    CT45A5    DDX26B    SAGE1

    Find genes that share paralogs with CT45A6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CT45A6 (see all 62)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2010152471,2
    C--134967333(+) TCTTTG/TCTTTG 2 E A mis10--------
    rs2018602431,2
    --134968565(+) CTGTC-/ATTATTCA 1 -- int10--------
    rs589608611,2
    C--134971128(+) GGGCAC/TCTGGG 1 -- ut513Minor allele frequency- T:0.00NA 4
    rs30033431,2
    C,F--134971152(-) AGACGC/TCTCCC 1 -- ut513Minor allele frequency- T:0.00NA 4
    rs30033421,2
    C,F--134971176(-) CAAACG/AGGATC 1 -- ut511Minor allele frequency- A:0.00NA 2
    rs30033411,2
    C--134971197(-) TTCCTC/TCCATC 1 -- ut513Minor allele frequency- T:0.00WA NA 5
    rs30033401,2
    C--134971230(-) CTGGGG/ACAGGC 1 -- ut512Minor allele frequency- A:0.00NA 3
    rs1930418561,2
    --134971335(+) CTGGCC/GCCCTC 1 -- us2k10--------
    rs59756261,2
    C--134971443(+) GACCCT/CGGCTC 1 -- us2k14Minor allele frequency- C:0.00NA CSA 6
    rs1838427621,2
    --134971469(+) CAACCA/GAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CT45A6 (134962849 - 134971244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CT45A6 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1531072CNV Deletion17803354
    esv2740498CNV Deletion23290073
    nsv499485CNV Loss21111241
    nsv7107CNV Loss18451855
    nsv527747CNV Gain19592680
    esv1010013CNV Gain20482838
    nsv469568CNV Gain16826518
    nsv9976CNV Gain+Loss18304495
    nsv471605CNV Gain+Loss15918152
    esv27752CNV Gain+Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300797    OMIM disorders: --


    Find genes that share disorders with CT45A6           About GenesLikeMe


    Export disorders for CT45A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CT45A6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CT45A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PubMed id 15905330)1, 2, 3 Chen Y.-T.... Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 541465 HGNC: 33271 Ensembl:ENSG00000226907 euGenes: HUgn541465 ECgene: CT45A6
    H-InvDB: CT45A6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CT45A6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CT45A6 gene:
    Search GeneIP for patents involving CT45A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for CT45A6
     SwitchGear Promoter luciferase reporter plasmids for CT45A6
     Search ThermoFisher Antibodies for CT45A6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CT45A6
     Browse compounds at ApexBio
     Search Addgene for plasmids for CT45A6
      Search eBioscience for proteins for CT45A6
      Search eBioscience for elisas for CT45A6
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CT45A6
     antibodies-online antibodies for CT45A6
      Search antibodies-online for kits for CT45A6
      Search antibodies-online for peptides for CT45A6
     antibodies-online proteins for CT45A6
           
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