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Aliases for CT45A5 Gene

Aliases for CT45A5 Gene

  • Cancer/Testis Antigen Family 45, Member A5 2 3 5
  • Cancer/Testis Antigen CT45-5 2 3
  • Cancer/Testis Antigen 45-5 3 4
  • Cancer/Testis Antigen 45A5 3 4
  • CT45.5 3
  • CT45-5 4
  • CT455 3

External Ids for CT45A5 Gene

Previous GeneCards Identifiers for CT45A5 Gene

  • GC0XM134776
  • GC0XM134944

Summaries for CT45A5 Gene

Entrez Gene Summary for CT45A5 Gene

  • This gene represents one of a cluster of several similar genes located on the q arm of chromosome X. The genes in this cluster encode members of the cancer/testis (CT) family of antigens, and are distinct from other CT antigens. These antigens are thought to be novel therapeutic targets for human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CT45A5 Gene

CT45A5 (Cancer/Testis Antigen Family 45, Member A5) is a Protein Coding gene. An important paralog of this gene is CT45A6.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CT45A5 Gene

Genomics for CT45A5 Gene

Regulatory Elements for CT45A5 Gene

Genomic Location for CT45A5 Gene

Chromosome:
X
Start:
135,777,130 bp from pter
End:
135,794,806 bp from pter
Size:
17,677 bases
Orientation:
Minus strand

Genomic View for CT45A5 Gene

Genes around CT45A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CT45A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CT45A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CT45A5 Gene

Proteins for CT45A5 Gene

  • Protein details for CT45A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMU8-CT455_HUMAN
    Recommended name:
    Cancer/testis antigen family 45 member A5
    Protein Accession:
    P0DMU8
    Secondary Accessions:
    • A8K842
    • B7ZMC5
    • Q6NSH3

    Protein attributes for CT45A5 Gene

    Size:
    189 amino acids
    Molecular mass:
    21232 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CT45A5 Gene

Proteomics data for CT45A5 Gene at MOPED

Post-translational modifications for CT45A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CT45A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CT45A5 Gene

Domains & Families for CT45A5 Gene

Protein Domains for CT45A5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CT45A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0DMU8

UniProtKB/Swiss-Prot:

CT455_HUMAN :
  • Belongs to the CT45 family.
Family:
  • Belongs to the CT45 family.
genes like me logo Genes that share domains with CT45A5: view

No data available for Gene Families for CT45A5 Gene

Function for CT45A5 Gene

Phenotypes for CT45A5 Gene

GenomeRNAi human phenotypes for CT45A5:
genes like me logo Genes that share phenotypes with CT45A5: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CT45A5 Gene

Localization for CT45A5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CT45A5 Gene COMPARTMENTS Subcellular localization image for CT45A5 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CT45A5 Gene

Pathways & Interactions for CT45A5 Gene

SuperPathways for CT45A5 Gene

No Data Available

Interacting Proteins for CT45A5 Gene

Gene Ontology (GO) - Biological Process for CT45A5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CT45A5 Gene

Drugs & Compounds for CT45A5 Gene

No Compound Related Data Available

Transcripts for CT45A5 Gene

mRNA/cDNA for CT45A5 Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CT45A5 Gene

Cancer/testis antigen family 45, member A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CT45A5 Gene

No ASD Table

Relevant External Links for CT45A5 Gene

GeneLoc Exon Structure for
CT45A5
ECgene alternative splicing isoforms for
CT45A5

Expression for CT45A5 Gene

mRNA expression in normal human tissues for CT45A5 Gene

mRNA differential expression in normal tissues according to GTEx for CT45A5 Gene

This gene is overexpressed in Testis (x25.3) and Brain - Spinal cord (cervical c-1) (x4.1).

Protein differential expression in normal tissues from HIPED for CT45A5 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CT45A5 Gene



SOURCE GeneReport for Unigene cluster for CT45A5 Gene Hs.535081

mRNA Expression by UniProt/SwissProt for CT45A5 Gene

P0DMU8-CT455_HUMAN
Tissue specificity: Testis specific. Expressed in cancer cell lines.
genes like me logo Genes that share expression patterns with CT45A5: view

Protein tissue co-expression partners for CT45A5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CT45A5 Gene

Orthologs for CT45A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CT45A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 36 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 26 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 5 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 7 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 8 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 6 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ddx26b 36
  • 5 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta IntS6 36
  • 3 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dic-1 36
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 4 (a)
OneToMany
Species with no ortholog for CT45A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CT45A5 Gene

ENSEMBL:
Gene Tree for CT45A5 (if available)
TreeFam:
Gene Tree for CT45A5 (if available)

Paralogs for CT45A5 Gene

(7) SIMAP similar genes for CT45A5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CT45A5: view

Variants for CT45A5 Gene

Sequence variations from dbSNP and Humsavar for CT45A5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs4031099 -- 135,780,102(+) TGGAA(C/G)CCAGG intron-variant
rs3003349 -- 135,779,763(-) CACAC(A/G)TATCT intron-variant
rs5974564 -- 135,787,003(+) CTCCC(A/G)AGAAG intron-variant, upstream-variant-2KB
rs5975616 -- 135,780,066(+) TCAAA(C/T)TCACT intron-variant
rs6635168 -- 135,780,252(+) CTTTC(C/T)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CT45A5 Gene

Variant ID Type Subtype PubMed ID
dgv2477e1 CNV Complex 17122850
esv785 CNV CNV 17122850
esv27752 CNV Gain+Loss 19812545
dgv2479e1 CNV Complex 17122850
esv2740498 CNV Deletion 23290073
nsv527747 CNV Gain 19592680
nsv7460 OTHER Inversion 18451855
esv1010013 CNV Gain 20482838
nsv9976 CNV Gain+Loss 18304495
dgv2480e1 CNV Complex 17122850
essv24688 CNV CNV 17122850
nsv469568 CNV Gain 16826518
nsv471605 CNV Gain+Loss 15918152
nsv7107 CNV Loss 18451855
nsv499485 CNV Loss 21111241
esv1531072 CNV Deletion 17803354

Variation tolerance for CT45A5 Gene

Gene Damage Index Score: 0.38; 8.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CT45A5 Gene

HapMap Linkage Disequilibrium report
CT45A5
Human Gene Mutation Database (HGMD)
CT45A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CT45A5 Gene

Disorders for CT45A5 Gene

Relevant External Links for CT45A5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CT45A5

No disorders were found for CT45A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CT45A5 Gene

Publications for CT45A5 Gene

  1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PMID: 15905330) Chen Y.-T. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for CT45A5 Gene

Sources for CT45A5 Gene

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