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CT45A4 Gene

protein-coding   GIFtS: 35
GCID: GC0XM134926

Cancer/Testis Antigen Family 45, Member A4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cancer/Testis Antigen Family 45, Member A41 2     CT45-42 3
Cancer/Testis Antigen CT45-41 2     CT45.42 5
Cancer/Testis Antigen 45-4/62 3     Cancer/Testis Antigen Family 45 Member A4/A62
Cancer/Testis Antigen 45A4/45A62 3     CT45-63

External Ids:    HGNC: 332691   Entrez Gene: 4415202   Ensembl: ENSG000002288367   OMIM: 3007955   UniProtKB: Q8N7B73   

Export aliases for CT45A4 gene to outside databases

Previous GC identifer: GC0XM134757


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CT45A4 Gene:
CT45A4 (cancer/testis antigen family 45, member A4) is a protein-coding gene. An important paralog of this gene is INTS6.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CT45A4 gene promoter:
         MEF-2A   Nkx3-1 v4   MEF-2   HNF-1   Nkx3-1 v3   aMEF-2   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCT45A4 promoter sequence
   Search Chromatin IP Primers for CT45A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CT45A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26.3

CT45A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CT45A4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM134926:  view genomic region     (about GC identifiers)

Start:
134,928,331 bp from pter      End:
134,953,994 bp from pter
Size:
25,664 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CT454_HUMAN, Q8N7B7 (See protein sequence)
Recommended Name: Cancer/testis antigen family 45 member A4/A6  
Size: 189 amino acids; 21245 Da

Explore the universe of human proteins at neXtProt for CT45A4: NX_Q8N7B7

Explore proteomics data for CT45A4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CT45A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001017436.1  
    ENSEMBL proteins: 
     ENSP00000427342   ENSP00000405261   ENSP00000425805   ENSP00000392987  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8N7B7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CT45A4
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    extracellular1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CT45A4
    Interactions:

        Search GeneGlobe Interaction Network for CT45A4

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CT45A4 (CT454)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CT45A4 gene: 
    NM_001017436.1  

    Unigene Cluster for CT45A4:

    Cancer/testis antigen family 45, member A4
    Hs.568346
    Unigene Representative Sequence: AY743712
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487941 ENST00000434966(uc004ezd.3) ENST00000494421 ENST00000420087

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    Additional mRNA sequence: AY743712.1 

    2 DOTS entries:

    DT.121278213  DT.121278210 

    23 AceView cDNA sequences:

    BP371111 BM782882 BV200251 BC028711 AV700754 AV696887 BU193627 BI549606 
    AA757285 BU540102 CA419457 BI552760 BI770798 AI581344 NM_152582 BM761296 
    BU194796 BU940543 BM984608 BI460396 BF751332 AV695928 BU595224 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CT45A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CT45A4 Expression
    About this image

    CT45A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CT45A4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.568346

    UniProtKB/Swiss-Prot: CT454_HUMAN, Q8N7B7
    Tissue specificity: Testis specific. Expressed in cancer cell lines

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CT45A4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    Uncharacterized protein
    26(a)
    1 → many
    X(106183890-106201175)
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    8(a)
    1 → many
    4(4111910-4145007)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    6(a)
    1 → many
    GL343761.1(61201-94435)
    zebrafish
    (Danio rerio)
    Actinopterygii ddx26b6
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
    5(a)
    1 → many
    14(32436381-32478038) ENSDARG00000017931
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS66
    Integrator 6
    3(a)
    1 → many
    X(5632696-5641287)
    worm
    (Caenorhabditis elegans)
    Secernentea dic-16
    Protein DIC-1, isoform b
    4(a)
    1 → many
    IV(8692099-8696456) WBGene00000994


    ENSEMBL Gene Tree for CT45A4 (if available)
    TreeFam Gene Tree for CT45A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CT45A4 gene
    INTS62  CT45A22  CT45A52  CT45A12  SAGE12  CT45A62  DDX26B2  CT45A32  
    6 SIMAP similar genes for CT45A4 using alignment to 1 protein entry:     CT454_HUMAN:
    CT45A1    CT45A2    CT45A3    CT45A5    DDX26B    SAGE1

    Find genes that share paralogs with CT45A4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CT45A4 (see all 29)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2016488251,2
    C--134928281(+) GCTGA-/CTGATA 1 -- ds50010--------
    rs1870423351,2
    --134929710(+) ATAGTC/TGGTAA 1 -- int10--------
    rs2021622411,2
    C--134934039(+) AGAAAG/TAAAAC 1 -- int10--------
    rs2007079801,2
    C--134934617(+) GCCATA/CAAAAA 1 -- int10--------
    rs2004021261,2
    ----134935520(+) TACTGA/CGAGTG 1 -- int10--------
    rs1995729821,2
    ----134934284(+) TCAAAC/TATTTA 1 -- int10--------
    rs2003637241,2
    ----134930832(+) AACCAC/GTGAAG 2 T S mis10--------
    rs3759429181,2
    ----134935024(+) TAAAAG/TAAGAG 1 -- int10--------
    rs1999616571,2
    ----134935291(+) GTGCT-/TAAAAA 1 -- int10--------
    rs3746241431,2
    ----134928282(+) GGCTG-/CGATAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CT45A4 (134928331 - 134953994 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CT45A4 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740498CNV Deletion23290073
    nsv7105CNV Loss18451855
    nsv215CNV Loss15895083
    nsv7107CNV Loss18451855
    nsv527747CNV Gain19592680
    esv1010013CNV Gain20482838
    nsv469568CNV Gain16826518
    nsv9976CNV Gain+Loss18304495
    nsv471605CNV Gain+Loss15918152
    nsv517224CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300795    OMIM disorders: --


    Find genes that share disorders with CT45A4           About GenesLikeMe


    Export disorders for CT45A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CT45A4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CT45A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PubMed id 15905330)1, 2, 3 Chen Y.-T.... Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 441520 HGNC: 33269 AceView: LOC441520 Ensembl:ENSG00000228836 euGenes: HUgn441520
    ECgene: CT45A4 H-InvDB: CT45A4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CT45A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CT45A4 gene:
    Search GeneIP for patents involving CT45A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CT45A4
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     Search Addgene for plasmids for CT45A4
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