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Aliases for CT45A3 Gene

Aliases for CT45A3 Gene

  • Cancer/Testis Antigen Family 45 Member A3 2 3
  • Cancer/Testis Antigen Family 45 Member A4 3 4
  • Cancer/Testis Antigen CT45-3 2 3
  • Cancer/Testis Antigen 45-3 3 4
  • Cancer/Testis Antigen 45-4 3 4
  • Cancer/Testis Antigen 45A3 3 4
  • Cancer/Testis Antigen 45A4 3 4
  • CT45A4 3 4
  • CT45-3 3 4
  • CT45-4 3 4
  • Cancer/Testis Antigen Family 45, Member A4 2
  • Cancer/Testis Antigen Family 45, Member A3 5
  • CT45.3 3
  • CT45.4 3

External Ids for CT45A3 Gene

Previous HGNC Symbols for CT45A3 Gene

  • CT45A4

Previous GeneCards Identifiers for CT45A3 Gene

  • GC0XP134712
  • GC0XP134869

Summaries for CT45A3 Gene

GeneCards Summary for CT45A3 Gene

CT45A3 (Cancer/Testis Antigen Family 45 Member A3) is a Protein Coding gene. An important paralog of this gene is CT45A7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CT45A3 Gene

Genomics for CT45A3 Gene

Regulatory Elements for CT45A3 Gene


Genomic Location for CT45A3 Gene

Chromosome:
X
Start:
135,759,846 bp from pter
End:
135,777,544 bp from pter
Size:
17,699 bases
Orientation:
Minus strand

Genomic View for CT45A3 Gene

Genes around CT45A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CT45A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CT45A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CT45A3 Gene

Proteins for CT45A3 Gene

  • Protein details for CT45A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHU0-CT453_HUMAN
    Recommended name:
    Cancer/testis antigen family 45 member A3
    Protein Accession:
    Q8NHU0
    Secondary Accessions:
    • B2RU20
    • B7ZMC9
    • D3DTG6
    • P0DMU6
    • Q8N7B7

    Protein attributes for CT45A3 Gene

    Size:
    189 amino acids
    Molecular mass:
    21331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CT45A3 Gene

Post-translational modifications for CT45A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CT45A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CT45A3 Gene

Domains & Families for CT45A3 Gene

Protein Domains for CT45A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CT45A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHU0

UniProtKB/Swiss-Prot:

CT453_HUMAN :
  • Belongs to the CT45 family.
Family:
  • Belongs to the CT45 family.
genes like me logo Genes that share domains with CT45A3: view

No data available for Gene Families for CT45A3 Gene

Function for CT45A3 Gene

Gene Ontology (GO) - Molecular Function for CT45A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with CT45A3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CT45A3 Gene

Localization for CT45A3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CT45A3 Gene

Pathways & Interactions for CT45A3 Gene

SuperPathways for CT45A3 Gene

No Data Available

Interacting Proteins for CT45A3 Gene

Gene Ontology (GO) - Biological Process for CT45A3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CT45A3 Gene

Drugs & Compounds for CT45A3 Gene

No Compound Related Data Available

Transcripts for CT45A3 Gene

mRNA/cDNA for CT45A3 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CT45A3 Gene

Cancer/testis antigen family 45, member A3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CT45A3 Gene

No ASD Table

Relevant External Links for CT45A3 Gene

GeneLoc Exon Structure for
CT45A3
ECgene alternative splicing isoforms for
CT45A3

Expression for CT45A3 Gene

mRNA expression in normal human tissues for CT45A3 Gene

mRNA differential expression in normal tissues according to GTEx for CT45A3 Gene

This gene is overexpressed in Testis (x35.5).

NURSA nuclear receptor signaling pathways regulating expression of CT45A3 Gene:

CT45A3

SOURCE GeneReport for Unigene cluster for CT45A3 Gene:

Hs.535080

mRNA Expression by UniProt/SwissProt for CT45A3 Gene:

Q8NHU0-CT453_HUMAN
Tissue specificity: Testis specific. Expressed in cancer cell lines.
genes like me logo Genes that share expression patterns with CT45A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CT45A3 Gene

Orthologs for CT45A3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CT45A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100609226 34
  • 98.24 (n)
  • 95.24 (a)
Species where no ortholog for CT45A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CT45A3 Gene

ENSEMBL:
Gene Tree for CT45A3 (if available)
TreeFam:
Gene Tree for CT45A3 (if available)

Paralogs for CT45A3 Gene

(7) SIMAP similar genes for CT45A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CT45A3: view

Variants for CT45A3 Gene

Sequence variations from dbSNP and Humsavar for CT45A3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs200277856 - 135,764,281(-) CAAAG(A/C)AAAGA reference, missense
rs2352889 -- 135,769,436(+) aagaa(A/C/G)gaaag intron-variant, upstream-variant-2KB
rs2446141 -- 135,770,868(-) TTGTC(A/G)CACAT intron-variant
rs2501512 -- 135,768,924(+) accgg(A/G)caggc intron-variant, upstream-variant-2KB
rs4031104 -- 135,769,428(+) aagaa(A/C)gaaag intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CT45A3 Gene

Variant ID Type Subtype PubMed ID
dgv2439e212 CNV loss 25503493
dgv2439e212 CNV loss 25503493
dgv2440e212 CNV loss 25503493
dgv2440e212 CNV loss 25503493
dgv2441e212 CNV gain 25503493
dgv2441e212 CNV gain 25503493
dgv2442e212 CNV loss 25503493
dgv2442e212 CNV loss 25503493
dgv2447e212 CNV gain 25503493
dgv2447e212 CNV gain 25503493
dgv2448e212 CNV gain 25503493
dgv2448e212 CNV gain 25503493
dgv2450e212 CNV gain 25503493
dgv2450e212 CNV gain 25503493
dgv2451e212 CNV loss 25503493
dgv2451e212 CNV loss 25503493
dgv2452e212 CNV gain 25503493
dgv2452e212 CNV gain 25503493
dgv2453e212 CNV gain 25503493
dgv2453e212 CNV gain 25503493
dgv2454e212 CNV gain 25503493
dgv2454e212 CNV gain 25503493
dgv2455e212 CNV gain 25503493
dgv2455e212 CNV gain 25503493
esv1010013 CNV gain 20482838
esv1010013 CNV gain 20482838
esv2740498 CNV deletion 23290073
esv2740498 CNV deletion 23290073
esv2758895 CNV gain+loss 17122850
esv2758895 CNV gain+loss 17122850
esv27752 CNV gain+loss 19812545
esv27752 CNV gain+loss 19812545
esv3333023 CNV duplication 20981092
esv3333023 CNV duplication 20981092
esv3356616 CNV duplication 20981092
esv3356616 CNV duplication 20981092
esv3364974 CNV duplication 20981092
esv3364974 CNV duplication 20981092
esv3427308 CNV duplication 20981092
esv3427308 CNV duplication 20981092
esv3433609 CNV duplication 20981092
esv3433609 CNV duplication 20981092
esv3574624 CNV loss 25503493
esv3574624 CNV loss 25503493
esv3574646 CNV loss 25503493
esv3574646 CNV loss 25503493
esv3574647 CNV loss 25503493
esv3574647 CNV loss 25503493
esv3574649 CNV loss 25503493
esv3574649 CNV loss 25503493
esv3574667 CNV loss 25503493
esv3574667 CNV loss 25503493
esv3574670 CNV loss 25503493
esv3574670 CNV loss 25503493
esv3577280 CNV gain 25503493
esv3577280 CNV gain 25503493
esv3577356 CNV gain 25503493
esv3577356 CNV gain 25503493
nsv1076725 CNV duplication 25765185
nsv1076725 CNV duplication 25765185
nsv1110626 CNV duplication 24896259
nsv1110626 CNV duplication 24896259
nsv1140068 CNV duplication 24896259
nsv1140068 CNV duplication 24896259
nsv1147487 CNV duplication 26484159
nsv1147487 CNV duplication 26484159
nsv469568 CNV gain 16826518
nsv469568 CNV gain 16826518
nsv471605 CNV gain+loss 15918152
nsv471605 CNV gain+loss 15918152
nsv527747 CNV gain 19592680
nsv527747 CNV gain 19592680
nsv7460 OTHER inversion 18451855
nsv7460 OTHER inversion 18451855

Relevant External Links for CT45A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CT45A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CT45A3 Gene

Disorders for CT45A3 Gene

Relevant External Links for CT45A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CT45A3

No disorders were found for CT45A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CT45A3 Gene

Publications for CT45A3 Gene

  1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PMID: 15905330) Chen Y.-T. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4 65
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 65

Products for CT45A3 Gene

Sources for CT45A3 Gene

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