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CT45A3 Gene

protein-coding   GIFtS: 37
GCID: GC0XP134869

Cancer/Testis Antigen Family 45, Member A3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cancer/Testis Antigen Family 45, Member A31 2     CT45-32 3
Cancer/Testis Antigen CT45-31 2     CT45.32 5
Cancer/Testis Antigen 45-32 3     Cancer/Testis Antigen Family 45 Member A32
Cancer/Testis Antigen 45A32 3     

External Ids:    HGNC: 332681   Entrez Gene: 4415192   Ensembl: ENSG000002324177   OMIM: 3007945   UniProtKB: Q8NHU03   

Export aliases for CT45A3 gene to outside databases

Previous GC identifer: GC0XP134712


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CT45A3 Gene:
CT45A3 (cancer/testis antigen family 45, member A3) is a protein-coding gene. Diseases associated with CT45A3 include sarcoma. An important paralog of this gene is CT45A4.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CT45A3 gene promoter:
         Nkx3-1   Nkx3-1 v4   HNF-1   Nkx3-1 v1   HNF-1A   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CT45A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26.3

CT45A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CT45A3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP134869:  view genomic region     (about GC identifiers)

Start:
134,883,488 bp from pter      End:
134,891,885 bp from pter
Size:
8,398 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CT453_HUMAN, Q8NHU0 (See protein sequence)
Recommended Name: Cancer/testis antigen family 45 member A3  
Size: 189 amino acids; 21331 Da
Secondary accessions: B2RU20 B7ZMC9 D3DTG6

Explore the universe of human proteins at neXtProt for CT45A3: NX_Q8NHU0

Explore proteomics data for CT45A3 at MOPED


See CT45A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001017435.1  
ENSEMBL proteins: 
 ENSP00000359769   ENSP00000421659   ENSP00000394635  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8NHU0


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol1
extracellular1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CT45A3
Interactions:

    Search GeneGlobe Interaction Network for CT45A3

1 Interacting protein for CT45A3 (Q8NHU03) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SDCBP2Q9H1903I2D: score=1 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CT45A3 (CT453)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CT45A3 gene: 
NM_001017435.1  

Unigene Cluster for CT45A3:

Cancer/testis antigen family 45, member A3
Hs.535080  [show with all ESTs]
Unigene Representative Sequence: BC028711
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000370734(uc004ezc.3) ENST00000485366 ENST00000443882
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Additional mRNA sequence: 

AY743711.1 BC028711.2 BC140735.1 BC140926.1 BC144437.1 

6 DOTS entries:

DT.95369049  DT.121288022  DT.103147  DT.121278210  DT.121278213  DT.121307899 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CT45A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTATTCCACC
CT45A3 Expression
About this image

CT45A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CT45A3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.535080

UniProtKB/Swiss-Prot: CT453_HUMAN, Q8NHU0
Tissue specificity: Testis specific. Expressed in cancer cell lines

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CT45A3 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
Uncharacterized protein
26(a)
1 → many
X(106183890-106201175)
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
8(a)
1 → many
4(4111910-4145007)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
6(a)
1 → many
GL343761.1(61201-94435)
zebrafish
(Danio rerio)
Actinopterygii ddx26b6
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
5(a)
1 → many
14(32436381-32478038) ENSDARG00000017931
fruit fly
(Drosophila melanogaster)
Insecta IntS66
Integrator 6
3(a)
1 → many
X(5632696-5641287)
worm
(Caenorhabditis elegans)
Secernentea dic-16
Protein DIC-1, isoform b
3(a)
1 → many
IV(8692099-8696456) WBGene00000994


ENSEMBL Gene Tree for CT45A3 (if available)
TreeFam Gene Tree for CT45A3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CT45A3 gene
LOC101060211  CT45A11 2  CT45A21 2  CT45A61 2  LOC102723680  LOC102723737  CT45A42  INTS62  
CT45A52  SAGE12  DDX26B2  
7 SIMAP similar genes for CT45A3 using alignment to 1 protein entry:     CT453_HUMAN:
CT45A1    CT45A2    CT45A4    CT45A6    CT45A5    DDX26B
SAGE1

CT45A3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CT45A3 (see all 14)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1387718391,2
C--134883122(+) GGCTGC/GAGTGC 1 -- us2k10--------
rs3702382571,2
----134891935(+) GTATC-/GCAGCC 1 -- ds50010--------
rs3756065161,2
----134882778(+) TCAAGC/TATTCT 1 -- us2k10--------
rs3738479261,2
----134883350(+) TTCCTA/CGCATA 1 -- us2k10--------
rs1435783781,2
----134885795(+) AAAAA-/AATGTCT 1 -- int10--------
rs2013661421,2
----134889381(+) CTTCAC/GTGGTT 2 T S mis10--------
rs2002426451,2
----134889309(+) AAAATC/TTGTTT 1 -- int10--------
rs2009502451,2
----134888833(+) GAGGCC/TGGTTG 1 -- int10--------
rs3746311261,2
----134891994(+) TATTT-/ACCACAC 1 -- ds50010--------
rs3682107071,2
----134882861(+) TTTAGC/TGAGAC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CT45A3 (134883488 - 134891885 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CT45A3 (see all 16):    About this table    
Variant IDTypeSubtypePubMed ID
esv2740498CNV Deletion23290073
nsv7105CNV Loss18451855
nsv215CNV Loss15895083
nsv527747CNV Gain19592680
esv1010013CNV Gain20482838
nsv469568CNV Gain16826518
nsv9976CNV Gain+Loss18304495
nsv471605CNV Gain+Loss15918152
nsv517224CNV Gain+Loss19592680
esv27752CNV Gain+Loss19812545

Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for CT45A3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300794    OMIM disorders: --

1 disease for CT45A3:    
About MalaCards
sarcoma


CT45A3 for disorders           About GeneDecksing


Export disorders for CT45A3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CT45A3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with CT45A3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PubMed id 15905330)1, 2, 3 Chen Y.-T.... Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2005)
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  3. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
  4. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 441519 HGNC: 33268 Ensembl:ENSG00000232417 euGenes: HUgn441519 ECgene: CT45A3
H-InvDB: CT45A3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CT45A3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CT45A3 gene:
Search GeneIP for patents involving CT45A3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CT45A3
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CT45A3
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CT45A3
 LSBio Antibodies in human, mouse, rat for CT45A3
Customized transgenic rodents for:
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 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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