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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CT45A3 Gene

protein-coding   GIFtS: 37
GCID: GC0XP134869

Cancer/Testis Antigen Family 45, Member A3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cancer/Testis Antigen Family 45, Member A31 2     CT45-32 3
Cancer/Testis Antigen CT45-31 2     CT45.32 5
Cancer/Testis Antigen 45-32 3     RP13-36C9.12
Cancer/Testis Antigen 45A32 3     Cancer/Testis Antigen Family 45 Member A32

External Ids:    HGNC: 332681   Entrez Gene: 4415192   Ensembl: ENSG000002324177   OMIM: 3007945   UniProtKB: Q8NHU03   

Export aliases for CT45A3 gene to outside databases

Previous GC identifer: GC0XP134712


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CT45A3 Gene: 
CT45A3 (cancer/testis antigen family 45, member A3) is a protein-coding gene. Diseases associated with CT45A3 include non-small cell lung carcinoma, and gastric cancer. An important paralog of this gene is INTS6.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011786.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CT45A3 gene promoter:
         Nkx3-1   Nkx3-1 v4   HNF-1   Nkx3-1 v1   HNF-1A   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CT45A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CT45A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26.3

CT45A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CT45A3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP134869:  view genomic region     (about GC identifiers)

Start:
134,883,488 bp from pter      End:
134,893,393 bp from pter
Size:
9,906 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CT453_HUMAN, Q8NHU0 (See protein sequence)
Recommended Name: Cancer/testis antigen family 45 member A3  
Size: 189 amino acids; 21331 Da
Secondary accessions: B2RU20 B7ZMC9 D3DTG6

Explore the universe of human proteins at neXtProt for CT45A3: NX_Q8NHU0

Explore proteomics data for CT45A3 at MOPED 

CT45A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CT45A3 Protein Expression

REFSEQ proteins: NP_001017435.1  
ENSEMBL proteins: 
 ENSP00000359769   ENSP00000421659   ENSP00000394635  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR011051 RmlC_Cupin

Graphical View of Domain Structure for InterPro Entry Q8NHU0

ProtoNet protein and cluster: Q8NHU0


CT45A3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CT45A3

1 Interacting protein for CT45A3 (Q8NHU03) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SDCBP2Q9H1903I2D: score=1 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CT45A3 (CT453)

Search CenterWatch for drugs/clinical trials and news about CT45A3 / CT453

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CT45A3 gene: 
NM_001017435.1  

Unigene Cluster for CT45A3:

Cancer/testis antigen family 45, member A3
Hs.535080  [show with all ESTs]
Unigene Representative Sequence: BC028711
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000370734(uc004ezc.3) ENST00000485366 ENST00000443882
miRNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CT45A3

Additional mRNA sequence: 

AY743711.1 BC028711.2 BC140735.1 BC140926.1 BC144437.1 

6 DOTS entries:

DT.95369049  DT.121288022  DT.103147  DT.121278210  DT.121278213  DT.121307899 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CT45A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTATTCCACC
CT45A3 Expression
About this image


See CT45A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CT45A3

SOURCE GeneReport for Unigene cluster: Hs.535080

UniProtKB/Swiss-Prot: CT453_HUMAN, Q8NHU0
Tissue specificity: Testis specific. Expressed in cancer cell lines

    SABiosciences Custom PCR Arrays for CT45A3
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CT45A3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CT45A3 gene from 6/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
--
34(a)
1 → many
X(106183890-106201175)
chicken
(Gallus gallus)
Aves --
--
7(a)
possible ortholog
4(4111910-4145007)
lizard
(Anolis carolinensis)
Reptilia DDX26B6
Uncharacterized protein
6(a)
possible ortholog
GL343761.1(61201-94435)
zebrafish
(Danio rerio)
Actinopterygii ddx26b6
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
4(a)
1 → many
14(32436381-32478038)
fruit fly
(Drosophila melanogaster)
Insecta IntS66
Integrator 6
2(a)
1 → many
X(5632696-5641287)
worm
(Caenorhabditis elegans)
Secernentea dic-16
Protein DIC-1, isoform b
2(a)
1 → many
IV(8692099-8696456)


ENSEMBL Gene Tree for CT45A3 (if available)
TreeFam Gene Tree for CT45A3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CT45A3 gene
CT45A11 2  CT45A21 2  CT45A41 2  CT45A61 2  INTS62  CT45A52  SAGE12  DDX26B2  
7 SIMAP similar genes for CT45A3 using alignment to 1 protein entry:     CT453_HUMAN:
CT45A1    CT45A2    CT45A4    CT45A6    CT45A5    DDX26B
SAGE1

CT45A3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/14 SNPs in CT45A3 are shown (see all 14)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1387718391,2
C--134883122(+) GGCTGC/GAGTGC 1 -- us2k10--------
rs3702382571,2
----134891935(+) GTATC-/GCAGCC 1 -- ds50010--------
rs3756065161,2
----134882778(+) TCAAGC/TATTCT 1 -- us2k10--------
rs3738479261,2
----134883350(+) TTCCTA/CGCATA 1 -- us2k10--------
rs1435783781,2
----134885795(+) AAAAA-/AATGTCT 1 -- int10--------
rs2013661421,2
----134889381(+) CTTCAC/GTGGTT 2 T S mis10--------
rs2002426451,2
----134889309(+) AAAATC/TTGTTT 1 -- int10--------
rs2009502451,2
----134888833(+) GAGGCC/TGGTTG 1 -- int10--------
rs3746311261,2
----134891994(+) TATTT-/ACCACAC 1 -- ds50010--------
rs3682107071,2
----134882861(+) TTTAGC/TGAGAC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CT45A3 (134883488 - 134893393 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/16 variations for CT45A3 (see all 16):    About this table     
Variant IDTypeSubtypePubMed ID
esv2740498CNV Deletion23290073
nsv7105CNV Loss18451855
nsv215CNV Loss15895083
nsv527747CNV Gain19592680
esv1010013CNV Gain20482838
nsv469568CNV Gain16826518
nsv9976CNV Gain+Loss18304495
nsv471605CNV Gain+Loss15918152
nsv517224CNV Gain+Loss19592680
esv27752CNV Gain+Loss19812545

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 300794    OMIM disorders: --

2 diseases for CT45A3:    About MalaCards
non-small cell lung carcinoma    gastric cancer


CT45A3 for disorders           About GeneDecksing


Export disorders for CT45A3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CT45A3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CT45A3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PubMed id 15905330)1, 2, 3 Chen Y.-T.... Simpson A.J.G. (2005)
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  3. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
  4. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 441519 HGNC: 33268 Ensembl:ENSG00000232417 euGenes: HUgn441519 ECgene: CT45A3
H-InvDB: CT45A3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CT45A3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CT45A3 gene:
Search GeneIP for patents involving CT45A3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CT45A3
 Browse SwitchGear 3'UTR luciferase reporter plasmids for CT45A3
 Browse SwitchGear Promoter luciferase reporter plasmids for CT45A3
 Search ThermoFisher Antibodies for CT45A3
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CT45A3
 inGenious Targeting Laboratory - Custom generated mouse model solutions for CT45A3
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CT45A3
Customized:
 lentivirus for stable overexpression of CT45A3
 lentivirus expression plasmids for stable overexpression of CT45A3
 adenovirus for overexpression of CT45A3
 Search LSBio for Antibodies for CT45A3
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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