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Aliases for CT45A2 Gene

Aliases for CT45A2 Gene

  • Cancer/Testis Antigen Family 45, Member A2 2 3 5
  • Cancer/Testis Antigen 45-2 3 4
  • Cancer/Testis Antigen 45A2 3 4
  • CT45-2 3 4
  • Cancer/Testis Antigen CT45-2 2
  • Cancer/Testis Antigen CT45 3
  • CT45.2 3

External Ids for CT45A2 Gene

Previous GeneCards Identifiers for CT45A2 Gene

  • GC0XP134695
  • GC0XP134866

Summaries for CT45A2 Gene

Entrez Gene Summary for CT45A2 Gene

  • This gene represents one of a cluster of several similar genes located on the q arm of chromosome X. The genes in this cluster encode members of the cancer/testis (CT) family of antigens, and are distinct from other CT antigens. These antigens are thought to be novel therapeutic targets for human cancers. [provided by RefSeq, Apr 2014]

GeneCards Summary for CT45A2 Gene

CT45A2 (Cancer/Testis Antigen Family 45, Member A2) is a Protein Coding gene. An important paralog of this gene is CT45A6.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CT45A2 Gene

Genomics for CT45A2 Gene

Regulatory Elements for CT45A2 Gene

Enhancers for CT45A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CT45A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CT45A2 Gene

Chromosome:
X
Start:
135,811,668 bp from pter
End:
135,829,348 bp from pter
Size:
17,681 bases
Orientation:
Minus strand

Genomic View for CT45A2 Gene

Genes around CT45A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CT45A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CT45A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CT45A2 Gene

Proteins for CT45A2 Gene

  • Protein details for CT45A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5DJT8-CT452_HUMAN
    Recommended name:
    Cancer/testis antigen family 45 member A2
    Protein Accession:
    Q5DJT8
    Secondary Accessions:
    • Q5JRH3

    Protein attributes for CT45A2 Gene

    Size:
    189 amino acids
    Molecular mass:
    21363 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CT45A2 Gene

Proteomics data for CT45A2 Gene at MOPED

Post-translational modifications for CT45A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CT45A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CT45A2 Gene

Domains & Families for CT45A2 Gene

Protein Domains for CT45A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CT45A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5DJT8

UniProtKB/Swiss-Prot:

CT452_HUMAN :
  • Belongs to the CT45 family.
Family:
  • Belongs to the CT45 family.
genes like me logo Genes that share domains with CT45A2: view

No data available for Gene Families for CT45A2 Gene

Function for CT45A2 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CT45A2 Gene

Localization for CT45A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CT45A2 Gene

Pathways & Interactions for CT45A2 Gene

SuperPathways for CT45A2 Gene

No Data Available

Interacting Proteins for CT45A2 Gene

Gene Ontology (GO) - Biological Process for CT45A2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CT45A2 Gene

Drugs & Compounds for CT45A2 Gene

No Compound Related Data Available

Transcripts for CT45A2 Gene

mRNA/cDNA for CT45A2 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CT45A2 Gene

Cancer/testis antigen family 45, member A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CT45A2 Gene

No ASD Table

Relevant External Links for CT45A2 Gene

GeneLoc Exon Structure for
CT45A2
ECgene alternative splicing isoforms for
CT45A2

Expression for CT45A2 Gene

mRNA expression in normal human tissues for CT45A2 Gene

mRNA differential expression in normal tissues according to GTEx for CT45A2 Gene

This gene is overexpressed in Testis (x25.0).

Protein differential expression in normal tissues from HIPED for CT45A2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CT45A2 Gene



SOURCE GeneReport for Unigene cluster for CT45A2 Gene Hs.632281

mRNA Expression by UniProt/SwissProt for CT45A2 Gene

Q5DJT8-CT452_HUMAN
Tissue specificity: Testis specific. Expressed in cancer cell lines.
genes like me logo Genes that share expression patterns with CT45A2: view

Protein tissue co-expression partners for CT45A2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CT45A2 Gene

Orthologs for CT45A2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CT45A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100609226 35
  • 98.59 (n)
  • 95.77 (a)
Species with no ortholog for CT45A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CT45A2 Gene

ENSEMBL:
Gene Tree for CT45A2 (if available)
TreeFam:
Gene Tree for CT45A2 (if available)

Paralogs for CT45A2 Gene

(7) SIMAP similar genes for CT45A2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CT45A2: view

Variants for CT45A2 Gene

Sequence variations from dbSNP and Humsavar for CT45A2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2125265 -- 135,820,405(+) cccca(C/T)ctcag intron-variant, upstream-variant-2KB
rs2125266 -- 135,820,636(+) tctct(A/G)ctaaa intron-variant, upstream-variant-2KB
rs3752327 -- 135,816,425(+) GAACA(C/G)AGTGT intron-variant
rs3979636 -- 135,817,219(+) ttgaa(A/C)acaag intron-variant
rs4495599 -- 135,815,856(+) CGAAA(C/G)TCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CT45A2 Gene

Variant ID Type Subtype PubMed ID
dgv2477e1 CNV Complex 17122850
esv785 CNV CNV 17122850
esv27752 CNV Gain+Loss 19812545
dgv2479e1 CNV Complex 17122850
esv2740498 CNV Deletion 23290073
nsv517224 CNV Gain+Loss 19592680
nsv527747 CNV Gain 19592680
nsv7105 CNV Loss 18451855
nsv7460 OTHER Inversion 18451855
esv1010013 CNV Gain 20482838
nsv9976 CNV Gain+Loss 18304495
nsv215 CNV Loss 15895083
dgv2480e1 CNV Complex 17122850
essv24688 CNV CNV 17122850
nsv515174 CNV Complex 21397061
nsv469568 CNV Gain 16826518
nsv471605 CNV Gain+Loss 15918152

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for CT45A2 Gene

Disorders for CT45A2 Gene

Relevant External Links for CT45A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CT45A2

No disorders were found for CT45A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CT45A2 Gene

Publications for CT45A2 Gene

  1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PMID: 15905330) Chen Y.-T. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4 67
  2. A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia. (PMID: 20920256) Cerveira N. … Teixeira M.R. (BMC Cancer 2010) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CT45A2 Gene

Sources for CT45A2 Gene

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