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CT45A2 Gene

protein-coding   GIFtS: 32
GCID: GC0XP134866

Cancer/Testis Antigen Family 45, Member A2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cancer/Testis Antigen Family 45, Member A21 2     CT45.22 5
Cancer/Testis Antigen 45-22 3     Cancer/Testis Antigen CT45-21
Cancer/Testis Antigen 45A22 3     Cancer/Testis Antigen CT452
CT45-22 3     Cancer/Testis Antigen Family 45 Member A22

External Ids:    HGNC: 284001   Entrez Gene: 7289112   Ensembl: ENSG000002421857   OMIM: 3007935   UniProtKB: Q5DJT83   

Export aliases for CT45A2 gene to outside databases

Previous GC identifer: GC0XP134695


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CT45A2 Gene:
This gene represents one of a cluster of six similar genes located on the q arm of chromosome X. The genes in this
cluster encode members of the cancer/testis (CT) family of antigens, and are distinct from other CT antigens.
These antigens are thought to be novel therapeutic targets for human cancers. (provided by RefSeq, May 2010)

GeneCards Summary for CT45A2 Gene:
CT45A2 (cancer/testis antigen family 45, member A2) is a protein-coding gene. An important paralog of this gene is CT45A4.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CT45A2 gene promoter:
         Nkx3-1 v2   Nkx3-1   SRF   Nkx3-1 v4   HNF-1   SRF (504 AA)   Nkx3-1 v3   Nkx3-1 v1   HNF-1A   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CT45A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CT45A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26.3

CT45A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CT45A2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP134866:  view genomic region     (about GC identifiers)

Start:
134,866,214 bp from pter      End:
134,874,614 bp from pter
Size:
8,401 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CT452_HUMAN, Q5DJT8 (See protein sequence)
Recommended Name: Cancer/testis antigen family 45 member A2  
Size: 189 amino acids; 21303 Da
Secondary accessions: Q5JRH3

Explore the universe of human proteins at neXtProt for CT45A2: NX_Q5DJT8

Explore proteomics data for CT45A2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CT45A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689795.3  
    ENSEMBL proteins: 
     ENSP00000359772   ENSP00000421296   ENSP00000426611  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5DJT8


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CT45A2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    extracellular1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CT45A2
    Interactions:

        Search GeneGlobe Interaction Network for CT45A2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CT45A2 (CT452)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CT45A2 gene: 
    NM_152582.5  

    Unigene Cluster for CT45A2:

    Cancer/testis antigen family 45, member A2
    Hs.632281  [show with all ESTs]
    Unigene Representative Sequence: AK098689
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370736(uc004eyz.3 uc004ezb.3) ENST00000471213 ENST00000495729

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    Additional mRNA sequence: 

    AK098689.1 AY743710.1 

    2 DOTS entries:

    DT.121307899  DT.100021754 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CT45A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CT45A2 Expression
    About this image

    CT45A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CT45A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632281

    UniProtKB/Swiss-Prot: CT452_HUMAN, Q5DJT8
    Tissue specificity: Testis specific. Expressed in cancer cell lines

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CT45A2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    Uncharacterized protein
    26(a)
    1 → many
    X(106183890-106201175)
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    8(a)
    1 → many
    4(4111910-4145007)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    6(a)
    1 → many
    GL343761.1(61201-94435)
    zebrafish
    (Danio rerio)
    Actinopterygii ddx26b6
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
    5(a)
    1 → many
    14(32436381-32478038) ENSDARG00000017931
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS66
    Integrator 6
    3(a)
    1 → many
    X(5632696-5641287)
    worm
    (Caenorhabditis elegans)
    Secernentea dic-16
    Protein DIC-1, isoform b
    4(a)
    1 → many
    IV(8692099-8696456) WBGene00000994


    ENSEMBL Gene Tree for CT45A2 (if available)
    TreeFam Gene Tree for CT45A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CT45A2 gene
    CT45A61 2  CT45A31 2  LOC102723680  LOC102723737  LOC101060211  CT45A11 2  CT45A42  INTS62  
    CT45A52  SAGE12  DDX26B2  
    7 SIMAP similar genes for CT45A2 using alignment to 1 protein entry:     CT452_HUMAN:
    CT45A1    CT45A3    CT45A4    CT45A6    CT45A5    DDX26B
    SAGE1

    Find genes that share paralogs with CT45A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CT45A2 (see all 16)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998404191,2
    ----134873816(+) TATGAA/GGGTTC 1 -- int10--------
    rs3749679221,2
    ----134874705(+) TTTAA-/TGTGTGT 1 -- ds50010--------
    rs2003928271,2
    ----134873839(+) ACCCTC/TGCCAG 1 -- int10--------
    rs3744892921,2
    ----134874570(+) AACACA/GGAGGA 1 -- ds50010--------
    rs2019945471,2
    ----134872726(+) AGGACC/GTACTG 2 P R mis10--------
    rs2017652281,2
    ----134865586(+) TTTAGC/TAGAGA 1 -- us2k10--------
    rs2002171391,2
    ----134873795(+) TTTATA/GTTCCC 1 -- int10--------
    rs2012631451,2
    ----134872044(+) AAAATC/TTGTTT 1 -- int10--------
    rs2005971351,2
    ----134873747(+) TAGTTG/TTTTGA 1 -- int10--------
    rs2013663951,2
    ----134873867(+) AGACTA/GCCTCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CT45A2 (134866214 - 134874614 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CT45A2 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740498CNV Deletion23290073
    nsv7105CNV Loss18451855
    nsv215CNV Loss15895083
    nsv527747CNV Gain19592680
    esv1010013CNV Gain20482838
    nsv469568CNV Gain16826518
    nsv9976CNV Gain+Loss18304495
    nsv471605CNV Gain+Loss15918152
    nsv517224CNV Gain+Loss19592680
    esv27752CNV Gain+Loss19812545

    Locus Specific Mutation Databases (LSDB): CT45A2

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300793    OMIM disorders: --


    Find genes that share disorders with CT45A2           About GenesLikeMe


    Export disorders for CT45A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CT45A2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CT45A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PubMed id 15905330)1, 2, 3 Chen Y.-T.... Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    2. A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia. (PubMed id 20920256)1 Cerveira N....Teixeira M.R. (BMC Cancer 2010)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 728911 HGNC: 28400 Ensembl:ENSG00000242185 euGenes: HUgn728911 ECgene: CT45A2
    H-InvDB: CT45A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CT45A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CT45A2 gene:
    Search GeneIP for patents involving CT45A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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