CT45A2 Gene
protein-coding GIFtS: 35
GCID: GC0XP134866
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|
cancer/testis antigen family 45, member A2
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Aliases
for CT45A2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cancer/Testis Antigen Family 45, Member A21 2 | | Cancer/Testis Antigen 45A22 3 | | CT45-21 2 3 | | Cancer/Testis Antigen CT452 | | CT45.21 2 5 | | Cancer/Testis Antigen Family 45 Member A22 | | Cancer/Testis Antigen 45-22 3 | | |
Export aliases for CT45A2 gene to outside databasesPrevious GC identifer: GC0XP134695 |
Summaries
for CT45A2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CT45A2:
This gene represents one of a cluster of six similar genes located on the q arm of chromosome X. The genes in thiscluster encode members of the cancer/testis (CT) family of antigens, and are distinct from other CT antigens. Theseantigens are thought to be novel therapeutic targets for human cancers. (provided by RefSeq, May 2010)
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Genomic Views
for CT45A2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CT45A2 gene promoter:
Nkx3-1 v2 Nkx3-1 SRF Nkx3-1 v4 HNF-1 SRF (504 AA) Nkx3-1 v3 Nkx3-1 v1 HNF-1A
Other transcription factors
Search SABiosciences Chromatin IP Primers for CT45A2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CT45A2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26.3 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26.3CT45A2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP134866: view genomic region
(about GC identifiers)
Start:
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134,866,214 bp from pter |
End:
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134,875,839 bp from pter |
Size:
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9,626 bases |
Orientation:
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plus strand |
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Proteins
for CT45A2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CT452_HUMAN, Q5DJT8 (See
protein sequence)Recommended Name: Cancer/testis antigen family 45 member A2 Size: 189 amino acids; 21303 Da
Secondary accessions: Q5JRH3Explore the universe of human proteins at neXtProt for CT45A2: NX_Q5DJT8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5DJT8
CT45A2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689795.3
ENSEMBL proteins: ENSP00000359772 ENSP00000421296 ENSP00000426611
Human Recombinant Protein Products:
CT45A2 Antibody Products:
Assay Products for CT45A2: |
Protein
Domains /
Families
for CT45A2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CT45A2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5DJT8ProtoNet protein and cluster: Q5DJT8 |
Function
for CT45A2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CT45A2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CT45A2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CT45A2 (NM_152582) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CT45A2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CT45A2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CT45A2 |
|
Pathways & Interactions
for CT45A2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CT45A2
|
Drugs & Compounds
for CT45A2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CT45A2
Search CenterWatch for drugs/clinical trials and news about CT45A2 / CT452
|
Transcripts
for CT45A2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CT45A2 gene: NM_152582.5 Unigene Cluster for CT45A2: Cancer/testis antigen family 45, member A2 Hs.632281 [show with all ESTs]Unigene Representative Sequence: AK0986893 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370736(uc004eyz.3 uc004ezb.3) ENST00000471213 ENST00000495729
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CT45A2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CT45A2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CT45A2 (NM_152582) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CT45A2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CT45A2 |
Additional cDNA sequence: AK098689.1 AY743710.1 2 DOTS entries: DT.121307899 DT.100021754
GeneLoc Exon Structure
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Expression
for CT45A2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CT45A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CT45A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CT45A2
SOURCE GeneReport for Unigene cluster: Hs.632281
UniProtKB/Swiss-Prot: CT452_HUMAN, Q5DJT8Tissue specificity: Testis specific. Expressed in cancer cell lines
SABiosciences Custom PCR Arrays for CT45A2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CT45A2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CT45A2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CT45A2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CT45A2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CT45A2 |
Orthologs
for CT45A2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for CT45A2 gene from 2/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
fruit fly
(Drosophila melanogaster) |
Insecta |
IntS66 |
Integrator 6 |
3(a) |
1 → many |
X(5632696-5641287) |
worm
(Caenorhabditis elegans) |
Secernentea |
dic-16 |
-- |
3(a) |
1 → many |
IV(8692086-8696443) |
ENSEMBL Gene Tree for CT45A2 (if available)
TreeFam Gene Tree for CT45A2 (if available) |
Paralogs
for CT45A2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CT45A2 gene
- CT45A41 2 CT45A61 2 CT45A31 2 CT45A11 2 INTS62 CT45A52 SAGE12 DDX26B2
7 SIMAP similar genes for CT45A2 using alignment to 1 protein entry: CT452_HUMAN:CT45A1 CT45A3 CT45A4 CT45A6 CT45A5 DDX26B
SAGE1
CT45A2 for paralogs About GeneDecksing
|
Genomic Variants
for CT45A2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CT45A2 (134866214 - 134875839 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for CT45A2
14 CNVs: 31563 33178 74057 37000 0669 83765 96995 4174 74056 83764 52935 74058 3256 96994
1 Inversion: 37350
Locus Specific Mutation Databases (LSDB): CT45A2
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CT45A2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CT45A2 for disorders About GeneDecksing
OMIM gene information: 300793
OMIM disorders: --
5  diseases for CT45A2: About MalaCardsnon-small cell lung carcinoma lung carcinoma acute leukemia carcinoma
leukemia
Export disorders for CT45A2 gene to outside databases
|
Publications
for CT45A2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CT45A2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CT45A2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PubMed id 15905330)1, 2, 3 Chen Y.-T.... Simpson A.J.G. (2005)
- A novel spliced fusion of MLL with CT45A2 in a pediat ric biphenotypic acute leukemia. (PubMed id 20920256)1 Cerveira N....Teixeira M.R. (2010)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CT45A2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CT45A2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CT45A2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CT45A2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CT45A2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CT45A2 gene:
Search GeneIP for patents involving CT45A2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CT45A2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CT45A2 |
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