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Aliases for CT45A1 Gene

Aliases for CT45A1 Gene

  • Cancer/Testis Antigen Family 45, Member A1 2 3
  • Cancer/Testis Antigen CT45-1 2 3
  • Cancer/Testis Antigen 45-1 3 4
  • Cancer/Testis Antigen 45A1 3 4
  • CT45-1 3 4
  • CT45.1 3
  • CT45 3

External Ids for CT45A1 Gene

Previous GeneCards Identifiers for CT45A1 Gene

  • GC0XP134675
  • GC0XP134847

Summaries for CT45A1 Gene

GeneCards Summary for CT45A1 Gene

CT45A1 (Cancer/Testis Antigen Family 45, Member A1) is a Protein Coding gene. An important paralog of this gene is CT45A3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CT45A1 Gene

Genomics for CT45A1 Gene

Regulatory Elements for CT45A1 Gene

Genomic Location for CT45A1 Gene

Chromosome:
X
Start:
135,708,398 bp from pter
End:
135,723,539 bp from pter
Size:
15,142 bases
Orientation:
Plus strand

Genomic View for CT45A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CT45A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CT45A1 Gene

Proteins for CT45A1 Gene

  • Protein details for CT45A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYN5-CT451_HUMAN
    Recommended name:
    Cancer/testis antigen family 45 member A1
    Protein Accession:
    Q5HYN5
    Secondary Accessions:
    • B9EIR8

    Protein attributes for CT45A1 Gene

    Size:
    189 amino acids
    Molecular mass:
    21273 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CT45A1 Gene

Proteomics data for CT45A1 Gene at MOPED

Post-translational modifications for CT45A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CT45A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CT45A1 Gene

Domains & Families for CT45A1 Gene

Protein Domains for CT45A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CT45A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5HYN5

UniProtKB/Swiss-Prot:

CT451_HUMAN :
  • Belongs to the CT45 family
Family:
  • Belongs to the CT45 family
genes like me logo Genes that share domains with CT45A1: view

No data available for Gene Families for CT45A1 Gene

Function for CT45A1 Gene

Phenotypes for CT45A1 Gene

GenomeRNAi human phenotypes for CT45A1:
genes like me logo Genes that share phenotypes with CT45A1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CT45A1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CT45A1 Gene

Localization for CT45A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CT45A1 Gene

Pathways & Interactions for CT45A1 Gene

SuperPathways for CT45A1 Gene

No Data Available

Interacting Proteins for CT45A1 Gene

Gene Ontology (GO) - Biological Process for CT45A1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CT45A1 Gene

Drugs & Compounds for CT45A1 Gene

No Compound Related Data Available

Transcripts for CT45A1 Gene

mRNA/cDNA for CT45A1 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CT45A1 Gene

Cancer/testis antigen family 45, member A1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CT45A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CT45A1 Gene

No ASD Table

Relevant External Links for CT45A1 Gene

GeneLoc Exon Structure for
CT45A1
ECgene alternative splicing isoforms for
CT45A1

Expression for CT45A1 Gene

mRNA expression in normal human tissues for CT45A1 Gene

mRNA differential expression in normal tissues according to GTEx for CT45A1 Gene

This gene is overexpressed in Testis (x27.1), Brain - Nucleus accumbens (basal ganglia) (x5.3), and Brain - Hypothalamus (x4.6).

Protein differential expression in normal tissues from HIPED for CT45A1 Gene

This gene is overexpressed in Bone (52.5) and Lung (16.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CT45A1 Gene



SOURCE GeneReport for Unigene cluster for CT45A1 Gene Hs.460937

mRNA Expression by UniProt/SwissProt for CT45A1 Gene

Q5HYN5-CT451_HUMAN
Tissue specificity: Testis specific. Expressed in cancer cell lines.
genes like me logo Genes that share expression patterns with CT45A1: view

Protein tissue co-expression partners for CT45A1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CT45A1 Gene

Orthologs for CT45A1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CT45A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100609226 35
  • 98.06 (n)
  • 94.71 (a)
Species with no ortholog for CT45A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CT45A1 Gene

ENSEMBL:
Gene Tree for CT45A1 (if available)
TreeFam:
Gene Tree for CT45A1 (if available)

Paralogs for CT45A1 Gene

Paralogs for CT45A1 Gene

(7) SIMAP similar genes for CT45A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CT45A1: view

Variants for CT45A1 Gene

Sequence variations from dbSNP and Humsavar for CT45A1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1937730 -- 135,706,975(-) agcag(A/G)gtgtg upstream-variant-2KB
rs1937731 -- 135,706,940(-) cacaa(A/C)gctta upstream-variant-2KB
rs1937733 -- 135,722,905(+) CTATC(C/T)GTCAC intron-variant
rs2489989 -- 135,707,383(+) TTGTG(C/T)GAATA upstream-variant-2KB
rs2489990 -- 135,707,704(+) ATCCA(C/T)GAACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CT45A1 Gene

Variant ID Type Subtype PubMed ID
dgv2477e1 CNV Complex 17122850
esv785 CNV CNV 17122850
esv27752 CNV Gain+Loss 19812545
dgv2479e1 CNV Complex 17122850
esv2740498 CNV Deletion 23290073
nsv517224 CNV Gain+Loss 19592680
nsv527747 CNV Gain 19592680
nsv7105 CNV Loss 18451855
nsv7460 OTHER Inversion 18451855
esv1010013 CNV Gain 20482838
nsv9976 CNV Gain+Loss 18304495
nsv215 CNV Loss 15895083

Variation tolerance for CT45A1 Gene

Gene Damage Index Score: 0.00; 0.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CT45A1 Gene

HapMap Linkage Disequilibrium report
CT45A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CT45A1 Gene

Disorders for CT45A1 Gene

Relevant External Links for CT45A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CT45A1
genes like me logo Genes that share disorders with CT45A1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CT45A1 Gene

Publications for CT45A1 Gene

  1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PMID: 15905330) Chen Y.-T. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 67
  2. CT45A1 acts as a new proto-oncogene to trigger tumorigenesis and cancer metastasis. (PMID: 24901056) Shang B. … Zhou Q. (Cell Death Dis 2014) 67
  3. Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas. (PMID: 20133697) Chen Y.T. … Old L.J. (Proc. Natl. Acad. Sci. U.S.A. 2010) 67
  4. Cancer/testis antigen CT45: analysis of mRNA and protein expression in human cancer. (PMID: 19296537) Chen Y.T. … Old L.J. (Int. J. Cancer 2009) 67
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 67

Products for CT45A1 Gene

Sources for CT45A1 Gene

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