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Aliases for CSTF3 Gene

Aliases for CSTF3 Gene

  • Cleavage Stimulation Factor Subunit 3 2 3 5
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 3, 77kD 2 3
  • Cleavage Stimulation Factor 77 KDa Subunit 3 4
  • CF-1 77 KDa Subunit 3 4
  • CSTF 77 KDa Subunit 3 4
  • CSTF-77 3 4
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 3, 77kDa 3
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 3 2

External Ids for CSTF3 Gene

Previous GeneCards Identifiers for CSTF3 Gene

  • GC11M034638
  • GC11M033249
  • GC11M033145
  • GC11M033070
  • GC11M033062
  • GC11M032800

Summaries for CSTF3 Gene

Entrez Gene Summary for CSTF3 Gene

  • The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSTF3 Gene

CSTF3 (Cleavage Stimulation Factor Subunit 3) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and mRNA binding.

UniProtKB/Swiss-Prot for CSTF3 Gene

  • One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs.

Gene Wiki entry for CSTF3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSTF3 Gene

Genomics for CSTF3 Gene

Regulatory Elements for CSTF3 Gene

Enhancers for CSTF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G032175 2.6 VISTA ENCODE dbSUPER 11 +985.8 985805 1.2 PKNOX1 ATF1 RAD21 RFX5 ZSCAN5C SCRT2 ZNF143 CREM DEK ZHX1 LOC101928385 CSTF3 LOC100506675 GC11M032121 ENSG00000255375
GH11G033187 1 FANTOM5 Ensembl ENCODE 17.1 -25.8 -25770 1.6 PRDM6 BHLHE40 POU5F1 WT1 CSTF3 CSTF3-AS1 HIPK3 TCP11L1 DEPDC7 GC11M033190 ENSG00000206808 GC11M033171
GH11G033133 1 Ensembl ENCODE 16.8 +27.7 27718 2.5 SIN3A RAD21 YY1 ZNF121 POLR2A ADNP HNF4G NFE2 ZNF362 JUND CSTF3 CSTF3-AS1 TCP11L1 DEPDC7 PIR59958
GH11G033773 1 ENCODE 14.3 -612.0 -611984 1.8 ARID4B SIN3A ZNF48 YY1 GLIS2 SP3 SP5 YY2 REST SMARCB1 CD59 CSTF3 FBXO3 FBXO3-AS1 NAT10 LOC105376617
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CSTF3 on UCSC Golden Path with GeneCards custom track

Promoters for CSTF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CSTF3 Gene

33,077,188 bp from pter
33,162,371 bp from pter
85,184 bases
Minus strand

Genomic View for CSTF3 Gene

Genes around CSTF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSTF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSTF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSTF3 Gene

Proteins for CSTF3 Gene

  • Protein details for CSTF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cleavage stimulation factor subunit 3
    Protein Accession:
    Secondary Accessions:
    • A8K471
    • D3DR04
    • E9PB40
    • Q32P22
    • Q96FQ8
    • Q96QD6
    • Q96QK4

    Protein attributes for CSTF3 Gene

    717 amino acids
    Molecular mass:
    82922 Da
    Quaternary structure:
    • Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1.

    Alternative splice isoforms for CSTF3 Gene


neXtProt entry for CSTF3 Gene

Post-translational modifications for CSTF3 Gene

  • Ubiquitination at Lys94 and isoforms=192
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CSTF3 Gene

Domains & Families for CSTF3 Gene

Gene Families for CSTF3 Gene

Protein Domains for CSTF3 Gene

Suggested Antigen Peptide Sequences for CSTF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CSTF3: view

No data available for UniProtKB/Swiss-Prot for CSTF3 Gene

Function for CSTF3 Gene

Molecular function for CSTF3 Gene

GENATLAS Biochemistry:
cleavage stimulation factor,subunit 3,homolog of the Drosophila supressor of forked protein SU(b),component of the 3 pre RNA polyadenylation complex
UniProtKB/Swiss-Prot Function:
One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs.

Gene Ontology (GO) - Molecular Function for CSTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 7590244
genes like me logo Genes that share ontologies with CSTF3: view
genes like me logo Genes that share phenotypes with CSTF3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSTF3 Gene

Localization for CSTF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSTF3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSTF3 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for CSTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7984242
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CSTF3: view

Pathways & Interactions for CSTF3 Gene

genes like me logo Genes that share pathways with CSTF3: view

Pathways by source for CSTF3 Gene

1 KEGG pathway for CSTF3 Gene
1 Qiagen pathway for CSTF3 Gene

Gene Ontology (GO) - Biological Process for CSTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation TAS 7984242
GO:0006379 mRNA cleavage TAS 7984242
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with CSTF3: view

No data available for SIGNOR curated interactions for CSTF3 Gene

Drugs & Compounds for CSTF3 Gene

(1) Additional Compounds for CSTF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CSTF3: view

Transcripts for CSTF3 Gene

Unigene Clusters for CSTF3 Gene

Cleavage stimulation factor, 3 pre-RNA, subunit 3, 77kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSTF3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2: - -
SP4: -

Relevant External Links for CSTF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CSTF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSTF3 Gene

Protein differential expression in normal tissues from HIPED for CSTF3 Gene

This gene is overexpressed in Lymph node (20.4) and Fetal ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSTF3 Gene

Protein tissue co-expression partners for CSTF3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CSTF3 Gene:


SOURCE GeneReport for Unigene cluster for CSTF3 Gene:


Evidence on tissue expression from TISSUES for CSTF3 Gene

  • Nervous system(4.7)
  • Liver(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with CSTF3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSTF3 Gene

Orthologs for CSTF3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSTF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CSTF3 34 35
  • 99.91 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
-- 35
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia CSTF3 35
  • 97 (a)
(Bos Taurus)
Mammalia CSTF3 34 35
  • 95.49 (n)
(Canis familiaris)
Mammalia CSTF3 34 35
  • 95.03 (n)
(Mus musculus)
Mammalia Cstf3 34 16 35
  • 93.44 (n)
(Rattus norvegicus)
Mammalia Cstf3 34
  • 91.16 (n)
(Gallus gallus)
Aves CSTF3 34 35
  • 84.52 (n)
(Anolis carolinensis)
Reptilia CSTF3 35
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cstf3 34
  • 79.66 (n)
MGC76035 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16844 34
(Danio rerio)
Actinopterygii cstf3 34 35
  • 76.58 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8931 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003019 34
  • 57.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta su(f) 36 34 35
  • 56.8 (n)
(Caenorhabditis elegans)
Secernentea suf-1 36 34 35
  • 56.4 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F26290g 34
  • 45.8 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNA14 34 35 37
  • 45.56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR137W 34
  • 42.5 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons CSTF77 34
  • 48.79 (n)
(Oryza sativa)
Liliopsida Os12g0571900 34
  • 47.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rna14 34
  • 46.76 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09435 34
  • 44.4 (n)
Species where no ortholog for CSTF3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSTF3 Gene

Gene Tree for CSTF3 (if available)
Gene Tree for CSTF3 (if available)

Paralogs for CSTF3 Gene

(1) SIMAP similar genes for CSTF3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CSTF3: view

No data available for Paralogs for CSTF3 Gene

Variants for CSTF3 Gene

Sequence variations from dbSNP and Humsavar for CSTF3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000034650 -- 33,116,607(+) GTGAA(A/G)GTCCA intron-variant
rs1000108214 -- 33,109,379(+) GCAGG(C/T)GAGAA intron-variant
rs1000115825 -- 33,129,754(+) TTTCT(G/T)CTTAC intron-variant
rs1000206325 -- 33,124,145(+) GTAAA(A/G)GATTA intron-variant
rs1000237741 -- 33,136,056(+) TAACA(C/T)TTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSTF3 Gene

Variant ID Type Subtype PubMed ID
dgv1093n100 CNV gain 25217958
dgv1742n54 CNV gain 21841781
esv2761660 CNV gain 21179565
esv2762904 CNV gain 21179565
esv3334264 CNV insertion 20981092
esv3579468 CNV loss 25503493
nsv467786 CNV gain 19166990
nsv521130 CNV gain 19592680
nsv975378 CNV duplication 23825009

Variation tolerance for CSTF3 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSTF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSTF3 Gene

Disorders for CSTF3 Gene

Relevant External Links for CSTF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CSTF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSTF3 Gene

Publications for CSTF3 Gene

  1. Complex protein interactions within the human polyadenylation machinery identify a novel component. (PMID: 10669729) Takagaki Y. … Manley J.L. (Mol. Cell. Biol. 2000) 3 4 22 64
  2. A subunit of the polyadenylation factor CstF is the human homologue of the Drosophila suppressor of forked protein. (PMID: 7984242) Takagaki Y. … Manley J.L. (Nature 1994) 2 3 4 64
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PMID: 14749727) Kaufmann I. … Keller W. (EMBO J. 2004) 3 4 64

Products for CSTF3 Gene

Sources for CSTF3 Gene

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