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Aliases for CSTF3 Gene

Aliases for CSTF3 Gene

  • Cleavage Stimulation Factor Subunit 3 2 3
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 3 2 3 5
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 3, 77kD 2 3
  • Cleavage Stimulation Factor 77 KDa Subunit 3 4
  • CF-1 77 KDa Subunit 3 4
  • CSTF 77 KDa Subunit 3 4
  • CSTF-77 3 4
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 3, 77kDa 3

External Ids for CSTF3 Gene

Previous GeneCards Identifiers for CSTF3 Gene

  • GC11M034638
  • GC11M033249
  • GC11M033145
  • GC11M033070
  • GC11M033062
  • GC11M032800

Summaries for CSTF3 Gene

Entrez Gene Summary for CSTF3 Gene

  • The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSTF3 Gene

CSTF3 (Cleavage Stimulation Factor Subunit 3) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and mRNA binding.

UniProtKB/Swiss-Prot for CSTF3 Gene

  • One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs.

Gene Wiki entry for CSTF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSTF3 Gene

Genomics for CSTF3 Gene

Regulatory Elements for CSTF3 Gene

Enhancers for CSTF3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CSTF3 on UCSC Golden Path with GeneCards custom track

Promoters for CSTF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CSTF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CSTF3 Gene

Chromosome:
11
Start:
33,077,188 bp from pter
End:
33,162,371 bp from pter
Size:
85,184 bases
Orientation:
Minus strand

Genomic View for CSTF3 Gene

Genes around CSTF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSTF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSTF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSTF3 Gene

Proteins for CSTF3 Gene

  • Protein details for CSTF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12996-CSTF3_HUMAN
    Recommended name:
    Cleavage stimulation factor subunit 3
    Protein Accession:
    Q12996
    Secondary Accessions:
    • A8K471
    • D3DR04
    • E9PB40
    • Q32P22
    • Q96FQ8
    • Q96QD6
    • Q96QK4

    Protein attributes for CSTF3 Gene

    Size:
    717 amino acids
    Molecular mass:
    82922 Da
    Quaternary structure:
    • Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1.

    Alternative splice isoforms for CSTF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSTF3 Gene

Proteomics data for CSTF3 Gene at MOPED

Post-translational modifications for CSTF3 Gene

  • Ubiquitination at Lys 94 and Lys 192
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CSTF3 Gene

Domains & Families for CSTF3 Gene

Protein Domains for CSTF3 Gene

Suggested Antigen Peptide Sequences for CSTF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12996

UniProtKB/Swiss-Prot:

CSTF3_HUMAN :
  • Contains 9 HAT repeats.
Similarity:
  • Contains 9 HAT repeats.
genes like me logo Genes that share domains with CSTF3: view

No data available for Gene Families for CSTF3 Gene

Function for CSTF3 Gene

Molecular function for CSTF3 Gene

GENATLAS Biochemistry:
cleavage stimulation factor,subunit 3,homolog of the Drosophila supressor of forked protein SU(b),component of the 3 pre RNA polyadenylation complex
UniProtKB/Swiss-Prot Function:
One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs.

Gene Ontology (GO) - Molecular Function for CSTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 1741396
genes like me logo Genes that share ontologies with CSTF3: view

Phenotypes for CSTF3 Gene

genes like me logo Genes that share phenotypes with CSTF3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSTF3 Gene

Localization for CSTF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSTF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSTF3 Gene COMPARTMENTS Subcellular localization image for CSTF3 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CSTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CSTF3: view

Pathways & Interactions for CSTF3 Gene

genes like me logo Genes that share pathways with CSTF3: view

Pathways by source for CSTF3 Gene

1 KEGG pathway for CSTF3 Gene
1 Qiagen pathway for CSTF3 Gene

Gene Ontology (GO) - Biological Process for CSTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006379 mRNA cleavage TAS 7984242
GO:0006396 RNA processing IEA --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with CSTF3: view

No data available for SIGNOR curated interactions for CSTF3 Gene

Drugs & Compounds for CSTF3 Gene

(1) Additional Compounds for CSTF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CSTF3: view

Transcripts for CSTF3 Gene

Unigene Clusters for CSTF3 Gene

Cleavage stimulation factor, 3 pre-RNA, subunit 3, 77kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSTF3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2: - -
SP3:
SP4: -

Relevant External Links for CSTF3 Gene

GeneLoc Exon Structure for
CSTF3
ECgene alternative splicing isoforms for
CSTF3

Expression for CSTF3 Gene

mRNA expression in normal human tissues for CSTF3 Gene

Protein differential expression in normal tissues from HIPED for CSTF3 Gene

This gene is overexpressed in Lymph node (20.4) and Fetal ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSTF3 Gene



SOURCE GeneReport for Unigene cluster for CSTF3 Gene Hs.44402

genes like me logo Genes that share expression patterns with CSTF3: view

Protein tissue co-expression partners for CSTF3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSTF3 Gene

Orthologs for CSTF3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSTF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSTF3 35
  • 95.49 (n)
  • 100 (a)
CSTF3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSTF3 35
  • 95.03 (n)
  • 99.86 (a)
CSTF3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cstf3 35
  • 93.44 (n)
  • 99.3 (a)
Cstf3 16
Cstf3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSTF3 35
  • 99.91 (n)
  • 100 (a)
CSTF3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cstf3 35
  • 91.16 (n)
  • 96.98 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CSTF3 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves CSTF3 35
  • 84.52 (n)
  • 98.19 (a)
CSTF3 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSTF3 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cstf3 35
  • 79.66 (n)
  • 94.27 (a)
MGC76035 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16844 35
zebrafish
(Danio rerio)
Actinopterygii cstf3 35
  • 76.58 (n)
  • 91.06 (a)
cstf3 36
  • 91 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8931 35
fruit fly
(Drosophila melanogaster)
Insecta su(f) 37
  • 57 (a)
su(f) 35
  • 56.8 (n)
  • 59.48 (a)
su(f) 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003019 35
  • 57.4 (n)
  • 60.66 (a)
worm
(Caenorhabditis elegans)
Secernentea suf-1 37
  • 49 (a)
suf-1 35
  • 56.4 (n)
  • 51.43 (a)
suf-1 36
  • 48 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR137W 35
  • 42.5 (n)
  • 30.83 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F26290g 35
  • 45.8 (n)
  • 31.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNA14 35
  • 45.56 (n)
  • 31.04 (a)
RNA14 36
  • 24 (a)
OneToOne
RNA14 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CSTF77 35
  • 48.79 (n)
  • 37.83 (a)
rice
(Oryza sativa)
Liliopsida Os12g0571900 35
  • 47.85 (n)
  • 35.48 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09435 35
  • 44.4 (n)
  • 35.18 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rna14 35
  • 46.76 (n)
  • 32.95 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for CSTF3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSTF3 Gene

ENSEMBL:
Gene Tree for CSTF3 (if available)
TreeFam:
Gene Tree for CSTF3 (if available)

Paralogs for CSTF3 Gene

(1) SIMAP similar genes for CSTF3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CSTF3: view

No data available for Paralogs for CSTF3 Gene

Variants for CSTF3 Gene

Sequence variations from dbSNP and Humsavar for CSTF3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs585813 -- 33,146,753(-) cagac(A/G/T)aataa intron-variant
rs585836 -- 33,148,192(-) TATAC(A/G)TCTTA intron-variant
rs601178 -- 33,145,691(-) gacta(C/T)aggtg intron-variant
rs620676 -- 33,158,223(+) AGATG(A/G)CTTCC intron-variant
rs631165 -- 33,146,329(-) GTGTA(C/T)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSTF3 Gene

Variant ID Type Subtype PubMed ID
dgv1065n71 CNV Gain 21882294
nsv467786 CNV Gain 19166990
nsv521130 CNV Gain 19592680
dgv1066n71 CNV Loss 21882294
nsv897199 CNV Loss 21882294
dgv1067n71 CNV Gain 21882294

Variation tolerance for CSTF3 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CSTF3 Gene

Disorders for CSTF3 Gene

Relevant External Links for CSTF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSTF3

No disorders were found for CSTF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSTF3 Gene

Publications for CSTF3 Gene

  1. A subunit of the polyadenylation factor CstF is the human homologue of the Drosophila suppressor of forked protein. (PMID: 7984242) Takagaki Y. … Manley J.L. (Nature 1994) 2 3 4 67
  2. Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila. (PMID: 12149458) Benoit B. … Simonelig M. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23
  3. Complex protein interactions within the human polyadenylation machinery identify a novel component. (PMID: 10669729) Takagaki Y. … Manley J.L. (Mol. Cell. Biol. 2000) 3 23
  4. An LRP16-containing preassembly complex contributes to NF-I_B activation induced by DNA double-strand breaks. (PMID: 25735744) Wu Z. … Han W. (Nucleic Acids Res. 2015) 3
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3

Products for CSTF3 Gene

Sources for CSTF3 Gene

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