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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSTF3 Gene

protein-coding   GIFtS: 57
GCID: GC11M033106

Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 3, 77kDa

(Previous names: cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kD)
  Search for CSTF3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 3, 77kDa1 2     Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 3, 77kD1
Cleavage Stimulation Factor 77 KDa Subunit2 3     CSTF-772
CF-1 77 KDa Subunit2 3     Cleavage Stimulation Factor Subunit 32
CSTF 77 KDa Subunit2 3     CstF-773

External Ids:    HGNC: 24851   Entrez Gene: 14792   Ensembl: ENSG000001761027   OMIM: 6003675   UniProtKB: Q129963   

Export aliases for CSTF3 gene to outside databases

Previous GC identifers: GC11M034638 GC11M033249 GC11M033145 GC11M033070 GC11M033062 GC11M032800


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSTF3 Gene:
The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that
combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation
and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both
CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding
different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for CSTF3 Gene: 
CSTF3 (cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa) is a protein-coding gene. Among its related super-pathways are mRNA Processing and Post-Elongation Processing of Intron-Containing pre-mRNA. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: CSTF3_HUMAN, Q12996
Function: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs

Gene Wiki entry for CSTF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSTF3 gene promoter:
         TBP   GR   Elk-1   Sp1   Pbx1a   Pax-6   GR-beta   HFH-1   TFIID   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSTF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CSTF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSTF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

CSTF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSTF3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M033106:  view genomic region     (about GC identifiers)

Start:
33,098,734 bp from pter      End:
33,183,917 bp from pter
Size:
85,184 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CSTF3_HUMAN, Q12996 (See protein sequence)
Recommended Name: Cleavage stimulation factor subunit 3  
Size: 717 amino acids; 82922 Da
Subunit: Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77
kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1
Subcellular location: Nucleus
Secondary accessions: A8K471 D3DR04 E9PB40 Q32P22 Q96FQ8 Q96QD6 Q96QK4
Alternative splicing: 3 isoforms:  Q12996-1   Q12996-2   Q12996-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CSTF3: NX_Q12996

Explore proteomics data for CSTF3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12996

  • CSTF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CSTF3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001028677.1  NP_001028678.1  NP_001317.1  

    ENSEMBL proteins: 
     ENSP00000435138   ENSP00000315791   ENSP00000431355   ENSP00000388711   ENSP00000393064  
     ENSP00000434753   ENSP00000431903  
    Reactome Protein details: Q12996
    Human Recombinant Protein Products for CSTF3: 
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    Cloud-Clone Corp. Proteins for CSTF3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    CSTF3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003107 HAT
     IPR008847 Suf

    Graphical View of Domain Structure for InterPro Entry Q12996

    ProtoNet protein and cluster: Q12996

    1 Blocks protein domain: IPB003107 RNA-processing protein

    UniProtKB/Swiss-Prot: CSTF3_HUMAN, Q12996
    Similarity: Contains 9 HAT repeats


    CSTF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSTF3_HUMAN, Q12996
    Function: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs

         Genatlas biochemistry entry for CSTF3:
    cleavage stimulation factor,subunit 3,homolog of the Drosophila supressor of forked protein SU(b),component of the
    3' pre RNA polyadenylation complex

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS1741396
         
    CSTF3 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidCSTF3 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CSTF3 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA processing0.46
    mRNA Splicing - Major Pathway0.82
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.79
    Post-Elongation Processing of the Transcript0.79
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    3Post-Elongation Processing of Intronless pre-mRNA
    Post-Elongation Processing of Intronless pre-mRNA0.61
    Processing of Capped Intronless Pre-mRNA0.61
    Processing of Intronless Pre-mRNAs0.61
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CSTF3
        Epithelial Tight Junctions

    1 BioSystems Pathway for CSTF3
        mRNA processing

    5/15        Reactome Pathways for CSTF3 (see all 15)
        mRNA Splicing - Major Pathway
    mRNA Splicing
    RNA Polymerase II Transcription
    Transcription
    Cleavage of Growing Transcript in the Termination Region


    1         Kegg Pathway  (Kegg details for CSTF3):
        mRNA surveillance pathway


    CSTF3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CSTF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/833 Interacting proteins for CSTF3 (Q129962, 3 ENSP000003157914) via UniProtKB, MINT, STRING, and/or I2D (see all 833)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC73Q6P1J92, 3, ENSP000003564054MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000356405
    CPSF3Q9UKF62, ENSP000002381124MINT-7945693 MINT-8286479 MINT-7947479 STRING: ENSP00000238112
    CPSF7Q8N6842, ENSP000003454124MINT-7945693 MINT-7947479 STRING: ENSP00000345412
    HNRNPA2B1P226262, ENSP000003466944MINT-7945693 MINT-7947479 STRING: ENSP00000346694
    HNRNPCP079102, ENSP000003196904MINT-7945693 MINT-7947479 STRING: ENSP00000319690
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006378mRNA polyadenylation TAS7984242
    GO:0006379mRNA cleavage TAS7984242

    CSTF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CSTF3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CSTF3

    1 Novoseek inferred chemical compound relationship for CSTF3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 47.2 1 12149458 (1)

    Search CenterWatch for drugs/clinical trials and news about CSTF3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CSTF3 gene (3 alternative transcripts): 
    NM_001033505.1  NM_001033506.1  NM_001326.2  

    Unigene Cluster for CSTF3:

    Cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
    Hs.44402  [show with all ESTs]
    Unigene Representative Sequence: NM_001326
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528865 ENST00000323959(uc001muh.3) ENST00000524827 ENST00000526480
    ENST00000438862(uc001mui.3) ENST00000431742(uc001muj.3) ENST00000524556
    ENST00000524775
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    Additional mRNA sequence: 

    AK290836.1 AK294204.1 AK297371.1 BC009792.1 BC010533.1 BC059948.1 BC108319.1 U15782.1 

    15 DOTS entries:

    DT.453153  DT.120739051  DT.86846375  DT.75167345  DT.92434063  DT.100754176  DT.100787504  DT.100754177 
    DT.92434067  DT.308156  DT.100672398  DT.120739023  DT.40263325  DT.92434066  DT.97780095 

    24/240 AceView cDNA sequences (see all 240):

    AI559515 AI763436 BM669021 BE349966 AA282801 BU178306 AU133365 BQ954077 
    BU685495 BM791131 BX644187 AA922378 AW274511 BU685894 BX952724 AA744581 
    AA156426 AA721477 BX954416 CB250473 NM_001326 AA748501 BM562604 CF121148 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CSTF3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -                                             
    SP2:        -           -                                             
    SP3:                                                                  
    SP4:                    -                                             


    ECgene alternative splicing isoforms for CSTF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSTF3 expression in normal human tissues (normalized intensities)      CSTF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGGAGACG
    CSTF3 Expression
    About this image


    CSTF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             hematopoietic stem cells   

    See CSTF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSTF3

    SOURCE GeneReport for Unigene cluster: Hs.44402
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSTF3 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cstf31 , 5 cleavage stimulation factor, 3' pre-RNA, subunit 31, 5 93.44(n)1
    99.3(a)1
      2 (54.84 cM)5
    2284101  NM_145529.31  NP_663504.11 
     1045905235 
    chicken
    (Gallus gallus)
    Aves CSTF31 cleavage stimulation factor, 3' pre-RNA, subunit 3, more 84.52(n)
    98.19(a)
      421595  NM_001012568.1  NP_001012586.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSTF36
    cleavage stimulation factor, 3' pre-RNA, subunit 3...
    96(a)
    1 ↔ 1
    1(61511002-61573197)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.168442 Xenopus laevis transcribed sequence with strong similarity more 82.18(n)    CA981633.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045871.12   -- 76.26(n)    BC045871.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta su(f)1 , 3 mRNA cleavage3
    suppressor of forked1
    57(a)3
    57.03(n)1
    59.23(a)1
      1 20E3
    33549941  NM_001015240.31  NP_001015240.11 
    worm
    (Caenorhabditis elegans)
    Secernentea suf-11 , 3 polyadenylation factor like3
    Protein SUF-11
    49(a)3
    56.4(n)1
    51.43(a)1
      II(8603783-8606467)3
    1743801  NM_063424.51  NP_495825.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RNA14(YMR061W)4
    RNA141
    Cleavage and polyadenylation factor I (CF I) component; more4
    Rna14p1
    44.19(n)1
    29.48(a)1
      13(392755-394788)4
    8550831, 4  NP_013777.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CSTF771 tetratricopeptide repeat-containing protein 48.42(n)
    37.31(a)
      838354  NM_101639.3  NP_173218.2 
    rice
    (Oryza sativa)
    Liliopsida Os12g05719001 hypothetical protein 47.8(n)
    35.48(a)
      4352587  NM_001073620.1  NP_001067088.1 


    ENSEMBL Gene Tree for CSTF3 (if available)
    TreeFam Gene Tree for CSTF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSTF3 gene
    5 SIMAP similar genes for CSTF3 using alignment to 5 protein entries:     CSTF3_HUMAN (see all proteins):
    FAM138A    FAM138B    FAM138C    FAM138F    FAM138D

    CSTF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1260 SNPs in CSTF3 are shown (see all 1260)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913527811,2
    --33105640(+) CCAACA/GTGATG 1 -- ds50010--------
    rs105355951,2
    C--33105982(+) AAAAA-/AGAC  
            
    AGACC
    1 -- ds50012Minor allele frequency- AGAC:0.00NA CSA 4
    rs73947841,2
    C,F,A,H--33105996(+) AGGAAG/AGAGTA 1 -- ds500114Minor allele frequency- A:0.36NS EA NA CSA WA 788
    rs748471451,2
    F--33106001(+) AGAGTA/GTGTGA 1 -- ds50010--------
    rs73947941,2
    C,A,H--33106017(+) ACATTT/CAGTAA 1 -- ds500112Minor allele frequency- C:0.33NA WA CSA EA 375
    rs1831085561,2
    --33106114(+) AAAGAA/GGCAGA 1 -- ds50010--------
    rs1859611651,2
    --33106220(+) CAAACA/TATAAG 1 -- ut310--------
    rs1396781381,2
    --33106543(+) CAAGAA/TCCTTG 1 -- ut310--------
    rs2019980071,2
    --33106599(+) AATCCC/TGGACA 1 -- ut310--------
    rs37587411,2
    C,F,A,H--33106616(-) CCTCTA/GCAGAA 1 -- ut31 ese329Minor allele frequency- N:0.00MN EA NA NS WA EU 4443

    HapMap Linkage Disequilibrium report for CSTF3 (33098734 - 33183917 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CSTF3:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1066n71CNV Loss21882294
    nsv897199CNV Loss21882294
    nsv521130CNV Gain19592680
    dgv1067n71CNV Gain21882294
    dgv1065n71CNV Gain21882294
    nsv467786CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CSTF3 for disorders           About MalaCards
    OMIM gene information: 600367    OMIM disorders: --


    CSTF3 for disorders           About GeneDecksing


    Export disorders for CSTF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSTF3 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with CSTF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A subunit of the polyadenylation factor CstF is the human homologue of the Drosophila suppressor of forked protein. (PubMed id 7984242)1, 2, 3 Takagaki Y. and Manley J.L. (1994)
    2. Complex protein interactions within the human polyadenylation machinery identify a novel component. (PubMed id 10669729)1, 2, 9 Takagaki Y. and Manley J.L. (2000)
    3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PubMed id 14749727)1, 2 Kaufmann I.... Keller W. (2004)
    7. Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila. (PubMed id 12149458)1, 9 Benoit B....Simonelig M. (2002)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
    10. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)1 Chu L....Tomasson M.H. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1479 HGNC: 2485 AceView: CSTF3 Ensembl:ENSG00000176102 euGenes: HUgn1479
    ECgene: CSTF3 Kegg: 1479 H-InvDB: CSTF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSTF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CSTF3 gene:
    Search GeneIP for patents involving CSTF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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