Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CSTF3 Gene

protein-coding   GIFtS: 59
GCID: GC11M033106

Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 3, 77kDa

(Previous names: cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kD)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 3, 77kDa1 2     Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 3, 77kD1
Cleavage Stimulation Factor 77 KDa Subunit2 3     CSTF-772
CF-1 77 KDa Subunit2 3     Cleavage Stimulation Factor Subunit 32
CSTF 77 KDa Subunit2 3     CstF-773

External Ids:    HGNC: 24851   Entrez Gene: 14792   Ensembl: ENSG000001761027   OMIM: 6003675   UniProtKB: Q129963   

Export aliases for CSTF3 gene to outside databases

Previous GC identifers: GC11M034638 GC11M033249 GC11M033145 GC11M033070 GC11M033062 GC11M032800


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CSTF3 Gene:
The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that
combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation
and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both
CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding
different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for CSTF3 Gene:
CSTF3 (cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa) is a protein-coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: CSTF3_HUMAN, Q12996
Function: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs

Gene Wiki entry for CSTF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSTF3 gene promoter:
         TBP   GR   Elk-1   Sp1   Pbx1a   Pax-6   GR-beta   HFH-1   TFIID   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSTF3 promoter sequence
   Search Chromatin IP Primers for CSTF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSTF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

CSTF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSTF3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M033106:  view genomic region     (about GC identifiers)

Start:
33,098,734 bp from pter      End:
33,183,917 bp from pter
Size:
85,184 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CSTF3_HUMAN, Q12996 (See protein sequence)
Recommended Name: Cleavage stimulation factor subunit 3  
Size: 717 amino acids; 82922 Da
Subunit: Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77
kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1
Secondary accessions: A8K471 D3DR04 E9PB40 Q32P22 Q96FQ8 Q96QD6 Q96QK4
Alternative splicing: 3 isoforms:  Q12996-1   Q12996-2   Q12996-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CSTF3: NX_Q12996

Explore proteomics data for CSTF3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys94, Lys192
  • Modification sites at PhosphoSitePlus

  • See CSTF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001028677.1  NP_001028678.1  NP_001317.1  

    ENSEMBL proteins: 
     ENSP00000435138   ENSP00000315791   ENSP00000431355   ENSP00000388711   ENSP00000393064  
     ENSP00000434753   ENSP00000431903  
    Reactome Protein details: Q12996

    CSTF3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CSTF3
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for CSTF3
    OriGene Custom Protein Services for CSTF3
    GenScript Custom Purified and Recombinant Proteins Services for CSTF3
    Novus Biologicals CSTF3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CSTF3

     
    Search eBioscience for Proteins for CSTF3 

     
    antibodies-online proteins for CSTF3 (3 products) 

     
    antibodies-online peptides for CSTF3

    CSTF3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CSTF3
    Novus Biologicals CSTF3 Antibodies
    Abcam antibodies for CSTF3
    Cloud-Clone Corp. Antibodies for CSTF3
    Search ThermoFisher Antibodies for CSTF3
    antibodies-online antibodies for CSTF3 (43 products) 

    CSTF3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CSTF3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CSTF3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CSTF3
    Cloud-Clone Corp. CLIAs for CSTF3
    Search eBioscience for ELISAs for CSTF3 
    antibodies-online kits for CSTF3 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR003107 HAT
     IPR008847 Suf

    Graphical View of Domain Structure for InterPro Entry Q12996

    ProtoNet protein and cluster: Q12996

    1 Blocks protein domain: IPB003107 RNA-processing protein

    UniProtKB/Swiss-Prot: CSTF3_HUMAN, Q12996
    Similarity: Contains 9 HAT repeats


    Find genes that share domains with CSTF3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSTF3_HUMAN, Q12996
    Function: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs

         Genatlas biochemistry entry for CSTF3:
    cleavage stimulation factor,subunit 3,homolog of the Drosophila supressor of forked protein SU(b),component of the
    3' pre RNA polyadenylation complex

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS1741396
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CSTF3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CSTF3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CSTF3:
    hsa-mir-132-3p (MIRT045842), hsa-mir-378a-3p (MIRT043935), hsa-mir-24-3p (MIRT030582), hsa-mir-1 (MIRT023876), hsa-mir-124-3p (MIRT022875)

    Block miRNA regulation of human, mouse, rat CSTF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSTF3 (see all 17):
    hsa-miR-513c hsa-miR-548a-3p hsa-miR-3667-5p hsa-miR-548g hsa-miR-1286 hsa-miR-1283 hsa-miR-409-3p hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidCSTF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CSTF3
    Predesigned siRNA for gene silencing in human, mouse, rat CSTF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CSTF3

    Clone
    Products:
         
    OriGene clones in human, mouse for CSTF3 (see all 21)
    OriGene ORF clones in mouse, rat for CSTF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CSTF3 (NM_001326)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSTF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSTF3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CSTF3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CSTF3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSTF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CSTF3_HUMAN, Q12996: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion2
    plasma membrane2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with CSTF3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CSTF3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    Processing of Capped Intronless Pre-mRNA0.52
    Cleavage of Growing Transcript in the Termination Region0.80
    Processing of Intronless Pre-mRNAs0.00
    mRNA 3-end processing0.80
    3Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    4Gene Expression
    Gene Expression0.40
    5Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36


    Find genes that share SuperPaths with CSTF3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CSTF3
        Epithelial Tight Junctions

    1 BioSystems Pathway for CSTF3
        mRNA processing

    4 Reactome Pathways for CSTF3
        mRNA Splicing - Major Pathway
    mRNA 3'-end processing
    Processing of Intronless Pre-mRNAs
    Cleavage of Growing Transcript in the Termination Region


    1 Kegg Pathway  (Kegg details for CSTF3):
        mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSTF3
    Interactions:

        Search GeneGlobe Interaction Network for CSTF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSTF3 (Q129962, 3 ENSP000003157914) via UniProtKB, MINT, STRING, and/or I2D (see all 939)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC73Q6P1J92, 3, ENSP000003564054MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000356405
    CPSF3Q9UKF62, ENSP000002381124MINT-7945693 MINT-8286479 MINT-7947479 STRING: ENSP00000238112
    CPSF7Q8N6842, ENSP000003454124MINT-7945693 MINT-7947479 STRING: ENSP00000345412
    HNRNPA2B1P226262, ENSP000003466944MINT-7945693 MINT-7947479 STRING: ENSP00000346694
    HNRNPCP079102, ENSP000003196904MINT-7945693 MINT-7947479 STRING: ENSP00000319690
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006378mRNA polyadenylation TAS7984242
    GO:0006379mRNA cleavage TAS7984242

    Find genes that share ontologies with CSTF3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CSTF3

    1 Novoseek inferred chemical compound relationship for CSTF3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 47.2 1 12149458 (1)



    Find genes that share compounds with CSTF3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CSTF3 gene (3 alternative transcripts): 
    NM_001033505.1  NM_001033506.1  NM_001326.2  

    Unigene Cluster for CSTF3:

    Cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
    Hs.44402  [show with all ESTs]
    Unigene Representative Sequence: NM_001326
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528865 ENST00000323959(uc001muh.3) ENST00000524827 ENST00000526480
    ENST00000438862(uc001mui.3) ENST00000431742(uc001muj.3) ENST00000524556
    ENST00000524775
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CSTF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSTF3 (see all 17):
    hsa-miR-513c hsa-miR-548a-3p hsa-miR-3667-5p hsa-miR-548g hsa-miR-1286 hsa-miR-1283 hsa-miR-409-3p hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidCSTF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CSTF3
    Predesigned siRNA for gene silencing in human, mouse, rat CSTF3
    Clone
    Products:
         
    OriGene clones in human, mouse for CSTF3 (see all 21)
    OriGene ORF clones in mouse, rat for CSTF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CSTF3 (NM_001326)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSTF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSTF3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CSTF3
    OriGene qSTAR qPCR primer pairs in human, mouse for CSTF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSTF3
      QuantiTect SYBR Green Assays in human, mouse, rat CSTF3
      QuantiFast Probe-based Assays in human, mouse, rat CSTF3

    Additional mRNA sequence: 

    AK290836.1 AK294204.1 AK297371.1 BC009792.1 BC010533.1 BC059948.1 BC108319.1 U15782.1 

    15 DOTS entries:

    DT.453153  DT.120739051  DT.86846375  DT.75167345  DT.92434063  DT.100754176  DT.100787504  DT.100754177 
    DT.92434067  DT.308156  DT.100672398  DT.120739023  DT.40263325  DT.92434066  DT.97780095 

    Selected AceView cDNA sequences (see all 240):

    BX954416 BG232033 BM836120 BC009792 CA312681 AI400050 BM556939 BM781901 
    AA614554 AA764823 BC059948 U15782 BU734496 AJ708686 BF725198 AA721477 
    BQ954077 CF121148 BM473491 BI518533 AU133883 CA418384 AA748501 AA465251 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CSTF3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -                                             
    SP2:        -           -                                             
    SP3:                                                                  
    SP4:                    -                                             


    ECgene alternative splicing isoforms for CSTF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CSTF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGGAGACG
    CSTF3 Expression
    About this image


    CSTF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CSTF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSTF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.44402
        Custom PCR Arrays for CSTF3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CSTF3
    OriGene qSTAR qPCR primer pairs in human, mouse for CSTF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSTF3
    QuantiTect SYBR Green Assays in human, mouse, rat CSTF3
    QuantiFast Probe-based Assays in human, mouse, rat CSTF3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSTF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSTF3 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cstf31 , 5 cleavage stimulation factor, 3' pre-RNA, subunit 31, 5 93.44(n)1
    99.3(a)1
      2 (54.84 cM)5
    2284101  NM_145529.31  NP_663504.11 
     1045905235 
    chicken
    (Gallus gallus)
    Aves CSTF31 cleavage stimulation factor, 3' pre-RNA, subunit 3, more 84.52(n)
    98.19(a)
      421595  NM_001012568.1  NP_001012586.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSTF36
    cleavage stimulation factor, 3' pre-RNA, subunit 3...
    96(a)
    1 ↔ 1
    1(61511002-61573197)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.168442 Xenopus laevis transcribed sequence with strong similarity more 82.18(n)    CA981633.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045871.12   -- 76.26(n)    BC045871.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta su(f)1 , 3 mRNA cleavage3
    suppressor of forked1
    57(a)3
    56.8(n)1
    59.48(a)1
      1 20E3
    33549941  NM_001015240.31  NP_001015240.11 
    worm
    (Caenorhabditis elegans)
    Secernentea suf-11 , 3 polyadenylation factor like3
    suf-11
    49(a)3
    56.4(n)1
    51.43(a)1
      II(8603783-8606467)3
    1743801  NM_063424.61  NP_495825.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RNA14(YMR061W)4
    RNA141
    Cleavage and polyadenylation factor I (CF I) component; more4
    RNA141
    45.56(n)1
    31.04(a)1
      13(392755-394788)4
    8550831, 4  NP_013777.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CSTF771 CSTF77 48.79(n)
    37.83(a)
      838354  NM_101639.3  NP_173218.2 
    rice
    (Oryza sativa)
    Liliopsida Os12g05719001 Os12g0571900 47.85(n)
    35.48(a)
      4352587  NM_001073620.1  NP_001067088.1 


    ENSEMBL Gene Tree for CSTF3 (if available)
    TreeFam Gene Tree for CSTF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CSTF3 gene
    1 SIMAP similar gene for CSTF3 using alignment to 5 protein entries:     CSTF3_HUMAN (see all proteins):
    FAM138C

    Find genes that share paralogs with CSTF3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CSTF3 (see all 1260)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913527811,2
    --33105640(+) CCAACA/GTGATG 1 -- ds50010--------
    rs105355951,2
    C--33105982(+) AAAAA-/AGAC  
            
    AGACC
    1 -- ds50012Minor allele frequency- AGAC:0.00NA CSA 4
    rs73947841,2
    C,F,A,H--33105996(+) AGGAAG/AGAGTA 1 -- ds500114Minor allele frequency- A:0.36NS EA NA CSA WA 788
    rs748471451,2
    F--33106001(+) AGAGTA/GTGTGA 1 -- ds50010--------
    rs73947941,2
    C,A,H--33106017(+) ACATTT/CAGTAA 1 -- ds500112Minor allele frequency- C:0.33NA WA CSA EA 375
    rs1831085561,2
    --33106114(+) AAAGAA/GGCAGA 1 -- ds50010--------
    rs1859611651,2
    --33106220(+) CAAACA/TATAAG 1 -- ut310--------
    rs1396781381,2
    --33106543(+) CAAGAA/TCCTTG 1 -- ut310--------
    rs2019980071,2
    --33106599(+) AATCCC/TGGACA 1 -- ut310--------
    rs37587411,2
    C,F,A,H--33106616(-) CCTCTA/GCAGAA 1 -- ut31 ese329Minor allele frequency- N:0.00MN EA NA NS WA EU 4443

    HapMap Linkage Disequilibrium report for CSTF3 (33098734 - 33183917 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CSTF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1066n71CNV Loss21882294
    nsv897199CNV Loss21882294
    nsv521130CNV Gain19592680
    dgv1067n71CNV Gain21882294
    dgv1065n71CNV Gain21882294
    nsv467786CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSTF3
    DNA2.0 Custom Variant and Variant Library Synthesis for CSTF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600367    OMIM disorders: --


    Find genes that share disorders with CSTF3           About GenesLikeMe


    Export disorders for CSTF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CSTF3 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with CSTF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A subunit of the polyadenylation factor CstF is the human homologue of the Drosophila suppressor of forked protein. (PubMed id 7984242)1, 2, 3 Takagaki Y. and Manley J.L. (Nature 1994)
    2. Complex protein interactions within the human polyadenylation machinery identify a novel component. (PubMed id 10669729)1, 2, 9 Takagaki Y. and Manley J.L. (Mol. Cell. Biol. 2000)
    3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PubMed id 14749727)1, 2 Kaufmann I.... Keller W. (EMBO J. 2004)
    7. Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila. (PubMed id 12149458)1, 9 Benoit B....Simonelig M. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. The conserved intronic cleavage and polyadenylation site of CstF-77 gene imparts control of 3' end processing activity through feedback autoregulation and by U1 snRNP. (PubMed id 23874216)1 Luo W....Tian B. (PLoS Genet. 2013)
    9. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1479 HGNC: 2485 AceView: CSTF3 Ensembl:ENSG00000176102 euGenes: HUgn1479
    ECgene: CSTF3 Kegg: 1479 H-InvDB: CSTF3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CSTF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CSTF3 gene:
    Search GeneIP for patents involving CSTF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CSTF3  
     OriGene qPCR primer pairs and template standards for CSTF3   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec for CSTF3   OriGene clones in human, mouse for CSTF3  
     OriGene qSTAR qPCR primer pairs in human, mouse for CSTF3   OriGene Purified Protein for CSTF3  
     OriGene ORF clones in mouse, rat for CSTF3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CSTF3   OriGene Custom Protein Services for CSTF3  

     
     
     Block miRNA regulation of human, mouse, rat CSTF3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CSTF3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSTF3 Predesigned siRNA for gene silencing in human, mouse, rat CSTF3
     QuantiFast Probe-based Assays in human, mouse, rat CSTF3 QuantiTect SYBR Green Assays in human, mouse, rat CSTF3
     Custom PCR Arrays for CSTF3 Search Chromatin IP Primers for CSTF3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSTF3  Search GeneGlobe Interaction Network for CSTF3
     Regulatory tfbs in CSTF3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CSTF3 GenScript cDNA clones with any tag delivered in your preferred vector for CSTF3
     GenScript Custom Assay Services for CSTF3 GenScript Custom overexpressing Cell Line Services for CSTF3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CSTF3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CSTF3 antibodies
     CSTF3 proteins
     Antibodies for CSTF3
     See all of Abcam's Antibodies, Kits and Proteins for CSTF3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CSTF3
     Antibodies for CSTF3
     ELISAs for CSTF3
     CLIAs for CSTF3



     Browse ESI BIO Cell Lines and PureStem Progenitors for CSTF3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSTF3
     SwitchGear 3'UTR luciferase reporter plasmids for CSTF3
     SwitchGear Promoter luciferase reporter plasmids for CSTF3
     Search ThermoFisher Antibodies for CSTF3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSTF3
     Browse compounds at ApexBio
     Search Addgene for plasmids for CSTF3
      Search eBioscience for proteins for CSTF3
      Search eBioscience for elisas for CSTF3
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CSTF3
     antibodies-online antibodies for CSTF3 (43 products)
     antibodies-online kits for CSTF3 (2 products)
     antibodies-online peptides for CSTF3
     antibodies-online proteins for CSTF3 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CSTF3 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4