CSTF2T Gene
protein-coding GIFtS: 59
GCID: GC10M053455
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cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa,...
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Aliases
for CSTF2T gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa, Tau Variant1 2 | | Cleavage Stimulation Factor Subunit 2 Tau Variant2 | | KIAA06891 3 5 | | CSTF 64 KDa Subunit Tau2 | | CstF-64T1 2 | | TauCstF-643 | | DKFZp434C10131 | | TauCstF-643 | | CF-1 64 KDa Subunit Tau2 | | CF-1 64 KDa Subunit Tau Variant3 | | Cleavage Stimulation Factor 64 KDa Subunit Tau2 | | Cleavage Stimulation Factor 64 KDa Subunit Tau Variant3 | | Cleavage Stimulation Factor Subunit 2 Tau2 | | CSTF 64 KDa Subunit Tau Variant3 |
Export aliases for CSTF2T gene to outside databasesPrevious GC identifers: GC10U990077 GC10M052325 GC10M053349 GC10M052801 GC10M053125 GC10M047433 |
Summaries
for CSTF2T gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CSTFT_HUMAN, Q9H0L4Function: May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved inthe binding to pre-mRNAs (By similarity)
Gene Wiki entry for CSTF2T
|
Genomic Views
for CSTF2T gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CSTF2T gene promoter:
SRF NF-1 NF-1/L SRF (504 AA) NF-kappaB YY1 Ik-2 POU2F1 POU2F1a NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CSTF2T
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSTF2T |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11 Ensembl cytogenetic band: 10q21.1 HGNC cytogenetic band: 10q11CSTF2T Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M053455: view genomic region
(about GC identifiers)
Start:
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53,455,246 bp from pter |
End:
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53,459,355 bp from pter |
Size:
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4,110 bases |
Orientation:
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minus strand |
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Proteins
for CSTF2T gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: CSTFT_HUMAN, Q9H0L4 (See
protein sequence)Recommended Name: Cleavage stimulation factor subunit 2 tau variant Size: 616 amino acids; 64437 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B2RAR9 O75174 Q53HK6 Q7LGE8 Q8N6T1Explore the universe of human proteins at neXtProt for CSTF2T: NX_Q9H0L4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0L4
CSTF2T Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056050.1
ENSEMBL proteins: ENSP00000332444
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CSTF2T for ontologies About GeneDecksing
CSTF2T Antibody Products:
Assay Products for CSTF2T: |
Protein
Domains /
Families
for CSTF2T gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CSTF2T for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H0L4ProtoNet protein and cluster: Q9H0L4 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: CSTFT_HUMAN, Q9H0L4Similarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for CSTF2T gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CSTFT_HUMAN, Q9H0L4Function: May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved inthe binding to pre-mRNAs (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSTF2T (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSTF2T (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSTF2T |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0003723 | RNA binding |
IEA | -- |
CSTF2T for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CSTF2T:
Animal Models:
Mouse knock-out Cstf2ttm1Ccma for CSTF2T
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Cstf2t):
CSTF2T for phenotypes About GeneDecksing
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Pathways & Interactions
for CSTF2T gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | mRNA surveillance pathway | | | 2 | mRNA Splicing - Major Pathway | | | 3 | Sertoli-Sertoli Cell Junction Dynamics | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CSTF2T
1  BioSystems Pathway for CSTF2T
1 
Kegg Pathway (Kegg details for CSTF2T):
CSTF2T for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CSTF2T
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/10 Interacting proteins for CSTF2T (Q9H0L42, 3 ENSP000003324444) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006397 | mRNA processing |
IEA | -- |
CSTF2T for ontologies About GeneDecksing
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Drugs & Compounds
for CSTF2T gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CSTF2T
Search CenterWatch for drugs/clinical trials and news about CSTF2T / CSTFT
|
Transcripts
for CSTF2T gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CSTF2T gene: NM_015235.2 Unigene Cluster for CSTF2T: Cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant Hs.591358 [show with all ESTs]Unigene Representative Sequence: NM_0152351 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000331173(uc001jjp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSTF2T (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSTF2T (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CSTF2T (NM_015235) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CSTF2T | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSTF2T |
Additional cDNA sequence: AB014589.1 AK222574.1 AK314318.1 AL136747.1 AY130299.1 BC017185.2 BC028239.1 4 DOTS entries: DT.100805593 DT.209559 DT.100658904 DT.95269907 24/110 AceView cDNA sequences (see all 110): BE047262 BP365240 AI417901 BU627261 AI949824 CB151320 N48963 AI375861 BM724577 BI789117 BI789188 BM847675 AL136747 BM931261 BI861922 AI872408 NM_015235 AA326683 BI918661 BG122243 BX443250 N45679 AI280778 CD685259
GeneLoc Exon Structure
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Expression
for CSTF2T gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CSTF2T expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGAAAATAA
About this image
See CSTF2T Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CSTF2T
SOURCE GeneReport for Unigene cluster: Hs.591358
SABiosciences Custom PCR Arrays for CSTF2T
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSTF2T
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSTF2T | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSTF2T | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSTF2T | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSTF2T |
Orthologs
for CSTF2T gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CSTF2T gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for CSTF2T (if available)
TreeFam Gene Tree for CSTF2T (if available) |
Paralogs
for CSTF2T gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CSTF2T gene
- CSTF22 RBM8A2
1 SIMAP similar gene for CSTF2T using alignment to 1 protein entry: CSTFT_HUMAN:CSTF2
CSTF2T for paralogs About GeneDecksing
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Genomic Variants
for CSTF2T gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Human Gene Mutation Database (HGMD): CSTF2T
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSTF2T |
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Disorders
/ Diseases
for CSTF2T gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CSTF2T for disorders About GeneDecksing
OMIM gene information: 611968
OMIM disorders: --
2  diseases for CSTF2T: About MalaCardsalzheimer's disease ataxia
1 disease from the University of Copenhagen DISEASES database for CSTF2T:Male infertility Human Genome Epidemiology (HuGE) Navigator: CSTF2T (1 document)
Export disorders for CSTF2T gene to outside databases
|
Publications
for CSTF2T gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CSTF2T gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with CSTF2T) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The gene CSTF2T, encoding the human variant CstF-64 polyadenylation protein CstF-64, lacks introns and may be associated with male sterility. (PubMed id 12408968)1, 2, 3, 9 Dass B.... MacDonald C.C. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice. (PubMed id 11113135)1, 3 Dass B....MacDonald C.C. (2001)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
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External Searches for CSTF2T gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CSTF2T gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CSTF2T gene
(According to HUGE)
About This Section
| |
Specialized Databases showing CSTF2T gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CSTF2T | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CSTF2T gene:
Search GeneIP for patents involving CSTF2T
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CSTF2T gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CSTF2T | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSTF2T | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSTF2T | | | OriGene Protein Over-expression Lysate for CSTF2T | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CSTF2T | | OriGene 3'-UTR Clone for CSTF2T | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSTF2T | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSTF2T | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CSTF2T | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CSTF2T | | OriGene Custom Protein Services for CSTF2T | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CSTF2T | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSTF2T | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSTF2T | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSTF2T | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSTF2T | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSTF2T |
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| | | | Search Tocris compounds for CSTF2T |
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 | | | CSTF2T Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSTF2T |
|  |  |  | | | | Search ThermoFisher Antibodies for CSTF2T |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSTF2T |
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