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Aliases for CSTF2T Gene

Aliases for CSTF2T Gene

  • Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa, Tau Variant 2
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 2, 64kDa, Tau Variant 2 3
  • TauCstF-64 3 4
  • KIAA0689 4 6
  • Cleavage Stimulation Factor 64 KDa Subunit Tau Variant 4
  • Cleavage Stimulation Factor Subunit 2 Tau Variant 3
  • Cleavage Stimulation Factor 64 KDa Subunit Tau 3
  • Cleavage Stimulation Factor Subunit 2 Tau 3
  • CF-1 64 KDa Subunit Tau Variant 4
  • CSTF 64 KDa Subunit Tau Variant 4
  • CF-1 64 KDa Subunit Tau 3
  • CSTF 64 KDa Subunit Tau 3
  • CstF-64T 3

External Ids for CSTF2T Gene

Summaries for CSTF2T Gene

GeneCards Summary for CSTF2T Gene

CSTF2T (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa, Tau Variant) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBMX2.

UniProtKB/Swiss-Prot for CSTF2T Gene

  • May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity).

Gene Wiki entry for CSTF2T Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSTF2T Gene

Genomics for CSTF2T Gene

Genomic Location for CSTF2T Gene

Start:
51,695,486 bp from pter
End:
51,699,595 bp from pter
Size:
4,110 bases
Orientation:
Minus strand

Genomic View for CSTF2T Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSTF2T Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSTF2T Gene

Regulatory Elements for CSTF2T Gene

Proteins for CSTF2T Gene

  • Protein details for CSTF2T Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0L4-CSTFT_HUMAN
    Recommended name:
    Cleavage stimulation factor subunit 2 tau variant
    Protein Accession:
    Q9H0L4
    Secondary Accessions:
    • B2RAR9
    • O75174
    • Q53HK6
    • Q7LGE8
    • Q8N6T1

    Protein attributes for CSTF2T Gene

    Size:
    616 amino acids
    Molecular mass:
    64437 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CSTF2T Gene

Proteomics data for CSTF2T Gene at MOPED

Post-translational modifications for CSTF2T Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys148, Lys189, and Lys194

Other Protein References for CSTF2T Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CSTF2T Gene

Domains for CSTF2T Gene

Gene Families for CSTF2T Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

UniProtKB/Swiss-Prot:

CSTFT_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q9H0L4
genes like me logo Genes that share domains with CSTF2T: view

Function for CSTF2T Gene

Molecular function for CSTF2T Gene

UniProtKB/Swiss-Prot Function: May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity).

Gene Ontology (GO) - Molecular Function for CSTF2T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CSTF2T: view

Phenotypes for CSTF2T Gene

MGI mutant phenotypes for CSTF2T:
inferred from 1 alleles
GenomeRNAi human phenotypes for CSTF2T:
genes like me logo Genes that share phenotypes with CSTF2T: view

Animal Models for CSTF2T Gene

MGI Knock Outs for CSTF2T:

miRNA for CSTF2T Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CSTF2T Gene

Localization for CSTF2T Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSTF2T Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSTF2T Gene COMPARTMENTS Subcellular localization image for CSTF2T gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CSTF2T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CSTF2T: view

Pathways for CSTF2T Gene

genes like me logo Genes that share pathways with CSTF2T: view

Pathways by source for CSTF2T Gene

1 Qiagen pathway for CSTF2T Gene
1 BioSystems pathway for CSTF2T Gene
1 KEGG pathway for CSTF2T Gene

Gene Ontology (GO) - Biological Process for CSTF2T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with CSTF2T: view

Transcripts for CSTF2T Gene

mRNA/cDNA for CSTF2T Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(110) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSTF2T Gene

Cleavage stimulation factor, 3 pre-RNA, subunit 2, 64kDa, tau variant:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSTF2T Gene

No ASD Table

Relevant External Links for CSTF2T Gene

GeneLoc Exon Structure for
CSTF2T
ECgene alternative splicing isoforms for
CSTF2T

Expression for CSTF2T Gene

mRNA expression in normal human tissues for CSTF2T Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSTF2T Gene

SOURCE GeneReport for Unigene cluster for CSTF2T Gene Hs.591358

genes like me logo Genes that share expressions with CSTF2T: view

Orthologs for CSTF2T Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSTF2T Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSTF2T 36
  • 99.29 (n)
  • 99.18 (a)
CSTF2T 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSTF2T 36
  • 88.63 (n)
  • 92.42 (a)
CSTF2T 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSTF2T 36
  • 76.74 (n)
  • 85.74 (a)
CSTF2T 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cstf2t 36
  • 87.42 (n)
  • 92.09 (a)
Cstf2t 16
Cstf2t 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cstf2t 36
  • 87.02 (n)
  • 91.33 (a)
chicken
(Gallus gallus)
Aves CSTF2 37
  • 76 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cstf2 37
  • 68 (a)
ManyToMany
cstf2 37
  • 68 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CstF-64 37
  • 51 (a)
OneToMany
CstF-64 38
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea cpf-2 37
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IST3 37
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToMany
Species with no ortholog for CSTF2T:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CSTF2T Gene

ENSEMBL:
Gene Tree for CSTF2T (if available)
TreeFam:
Gene Tree for CSTF2T (if available)

Paralogs for CSTF2T Gene

Paralogs for CSTF2T Gene

Selected SIMAP similar genes for CSTF2T Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CSTF2T: view

Variants for CSTF2T Gene

Structural Variations from Database of Genomic Variants (DGV) for CSTF2T Gene

Variant ID Type Subtype PubMed ID
nsv831875 CNV Gain 17160897

Relevant External Links for CSTF2T Gene

HapMap Linkage Disequilibrium report
CSTF2T
Human Gene Mutation Database (HGMD)
CSTF2T

No data available for Sequence variations from dbSNP and Humsavar for CSTF2T Gene

Disorders for CSTF2T Gene

(1) University of Copenhagen DISEASES for CSTF2T Gene

Relevant External Links for CSTF2T

Genetic Association Database (GAD)
CSTF2T
Human Genome Epidemiology (HuGE) Navigator
CSTF2T
genes like me logo Genes that share disorders with CSTF2T: view

No data available for UniProtKB/Swiss-Prot for CSTF2T Gene

Publications for CSTF2T Gene

  1. The gene CSTF2T, encoding the human variant CstF-64 polyadenylation protein CstF-64, lacks introns and may be associated with male sterility. (PMID: 12408968) Dass B. … MacDonald C.C. (Genomics 2002) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4
  4. The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice. (PMID: 11113135) Dass B. … MacDonald C.C. (J. Biol. Chem. 2001) 2 3
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for CSTF2T Gene

Sources for CSTF2T Gene

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