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Aliases for CSTF2T Gene

Aliases for CSTF2T Gene

  • Cleavage Stimulation Factor Subunit 2 Tau Variant 2 3 5
  • TauCstF-64 3 4
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 2, 64kDa, Tau Variant 2
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 2, Tau Variant 2
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 2, 64kDa, Tau 3
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 2, Tau 3
  • Cleavage Stimulation Factor 64 KDa Subunit Tau Variant 4
  • Cleavage Stimulation Factor Subunit 2, Tau Variant 2
  • Cleavage Stimulation Factor 64 KDa Subunit Tau 3
  • Cleavage Stimulation Factor Subunit 2, Tau 3
  • CF-1 64 KDa Subunit Tau Variant 4
  • CSTF 64 KDa Subunit Tau Variant 4
  • CF-1 64 KDa Subunit Tau 3
  • CSTF 64 KDa Subunit Tau 3
  • CstF-64T 3
  • KIAA0689 4

External Ids for CSTF2T Gene

Previous GeneCards Identifiers for CSTF2T Gene

  • GC10U990077
  • GC10M052325
  • GC10M053349
  • GC10M052801
  • GC10M053125
  • GC10M053455
  • GC10M047433

Summaries for CSTF2T Gene

GeneCards Summary for CSTF2T Gene

CSTF2T (Cleavage Stimulation Factor Subunit 2 Tau Variant) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Processing of Capped Intronless Pre-mRNA. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CSTF2.

UniProtKB/Swiss-Prot for CSTF2T Gene

  • May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity).

Gene Wiki entry for CSTF2T Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSTF2T Gene

Genomics for CSTF2T Gene

Regulatory Elements for CSTF2T Gene

Enhancers for CSTF2T Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F051697 1.1 ENCODE 7.6 +0.1 129 3.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CSTF2T GC10P051555
GH10F051918 0.7 Ensembl ENCODE 6.5 -219.4 -219445 0.7 JUN NR2F2 TRIM28 CSTF2T GC10P051941
GH10F051832 0.9 Ensembl ENCODE 4.7 -133.5 -133476 0.9 PKNOX1 JUN MAFG ZNF530 FOS NFE2 MAFK NFE2L2 CSTF2T GC10P051941
GH10F051629 0.4 ENCODE 5.3 +69.2 69241 2.5 ZNF610 CSTF2T GC10P051555
GH10F051267 0.4 ENCODE 4.8 +430.8 430796 2.6 IKZF1 ENSG00000231132 CSTF2T GC10P051268 GC10P051300
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CSTF2T on UCSC Golden Path with GeneCards custom track

Promoters for CSTF2T Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000355026 -205 2000 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for CSTF2T Gene

Chromosome:
10
Start:
51,695,486 bp from pter
End:
51,699,595 bp from pter
Size:
4,110 bases
Orientation:
Minus strand

Genomic View for CSTF2T Gene

Genes around CSTF2T on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSTF2T Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSTF2T Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSTF2T Gene

Proteins for CSTF2T Gene

  • Protein details for CSTF2T Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0L4-CSTFT_HUMAN
    Recommended name:
    Cleavage stimulation factor subunit 2 tau variant
    Protein Accession:
    Q9H0L4
    Secondary Accessions:
    • B2RAR9
    • O75174
    • Q53HK6
    • Q7LGE8
    • Q8N6T1

    Protein attributes for CSTF2T Gene

    Size:
    616 amino acids
    Molecular mass:
    64437 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CSTF2T Gene

Post-translational modifications for CSTF2T Gene

  • Ubiquitination at Lys 148, Lys 189, and Lys 194
  • Modification sites at PhosphoSitePlus

Other Protein References for CSTF2T Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CSTF2T Gene

Domains & Families for CSTF2T Gene

Gene Families for CSTF2T Gene

Suggested Antigen Peptide Sequences for CSTF2T Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0L4

UniProtKB/Swiss-Prot:

CSTFT_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with CSTF2T: view

Function for CSTF2T Gene

Molecular function for CSTF2T Gene

UniProtKB/Swiss-Prot Function:
May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity).

Gene Ontology (GO) - Molecular Function for CSTF2T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CSTF2T: view

Phenotypes for CSTF2T Gene

MGI mutant phenotypes for CSTF2T:
inferred from 1 alleles
GenomeRNAi human phenotypes for CSTF2T:
genes like me logo Genes that share phenotypes with CSTF2T: view

Animal Models for CSTF2T Gene

MGI Knock Outs for CSTF2T:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSTF2T Gene

Localization for CSTF2T Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSTF2T Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSTF2T gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CSTF2T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IBA --
genes like me logo Genes that share ontologies with CSTF2T: view

Pathways & Interactions for CSTF2T Gene

genes like me logo Genes that share pathways with CSTF2T: view

Pathways by source for CSTF2T Gene

1 KEGG pathway for CSTF2T Gene
1 Qiagen pathway for CSTF2T Gene

Gene Ontology (GO) - Biological Process for CSTF2T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0031124 mRNA 3-end processing IEA --
GO:0098789 pre-mRNA cleavage required for polyadenylation IBA --
genes like me logo Genes that share ontologies with CSTF2T: view

No data available for SIGNOR curated interactions for CSTF2T Gene

Transcripts for CSTF2T Gene

mRNA/cDNA for CSTF2T Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(110) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSTF2T Gene

Cleavage stimulation factor, 3 pre-RNA, subunit 2, 64kDa, tau variant:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSTF2T Gene

No ASD Table

Relevant External Links for CSTF2T Gene

GeneLoc Exon Structure for
CSTF2T
ECgene alternative splicing isoforms for
CSTF2T

Expression for CSTF2T Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CSTF2T Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSTF2T Gene

This gene is overexpressed in Liver (22.4), Testis (12.7), and Peripheral blood mononuclear cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSTF2T Gene



Protein tissue co-expression partners for CSTF2T Gene

NURSA nuclear receptor signaling pathways regulating expression of CSTF2T Gene:

CSTF2T

SOURCE GeneReport for Unigene cluster for CSTF2T Gene:

Hs.591358
genes like me logo Genes that share expression patterns with CSTF2T: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSTF2T Gene

Orthologs for CSTF2T Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSTF2T Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSTF2T 34 35
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia CSTF2T 34 35
  • 88.63 (n)
mouse
(Mus musculus)
Mammalia Cstf2t 34 16 35
  • 87.42 (n)
rat
(Rattus norvegicus)
Mammalia Cstf2t 34
  • 87.02 (n)
dog
(Canis familiaris)
Mammalia CSTF2T 34 35
  • 76.74 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves CSTF2 35
  • 76 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cstf2 35 35
  • 68 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CstF-64 36 35
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea cpf-2 35
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IST3 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToMany
Species where no ortholog for CSTF2T was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CSTF2T Gene

ENSEMBL:
Gene Tree for CSTF2T (if available)
TreeFam:
Gene Tree for CSTF2T (if available)

Paralogs for CSTF2T Gene

Paralogs for CSTF2T Gene

(1) SIMAP similar genes for CSTF2T Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CSTF2T: view

Variants for CSTF2T Gene

Sequence variations from dbSNP and Humsavar for CSTF2T Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1045767 -- 51,695,648(-) AGTTA(C/T)GCTTA intron-variant, utr-variant-3-prime
rs10998976 -- 51,700,730(+) AATAT(A/T)TGAAA intron-variant, upstream-variant-2KB
rs111331961 -- 51,698,273(+) AGACC(C/T)CAGTT intron-variant, reference, missense
rs112479167 -- 51,701,442(+) GATGC(A/G)CGACA intron-variant, upstream-variant-2KB
rs112627642 -- 51,698,895(+) CCCAG(A/G)GCCAG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CSTF2T Gene

Variant ID Type Subtype PubMed ID
nsv1045692 CNV gain 25217958
nsv831875 CNV gain 17160897

Variation tolerance for CSTF2T Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSTF2T Gene

Human Gene Mutation Database (HGMD)
CSTF2T
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSTF2T

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSTF2T Gene

Disorders for CSTF2T Gene

Relevant External Links for CSTF2T

Genetic Association Database (GAD)
CSTF2T
Human Genome Epidemiology (HuGE) Navigator
CSTF2T
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSTF2T

No disorders were found for CSTF2T Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSTF2T Gene

Publications for CSTF2T Gene

  1. The gene CSTF2T, encoding the human variant CstF-64 polyadenylation protein CstF-64, lacks introns and may be associated with male sterility. (PMID: 12408968) Dass B. … MacDonald C.C. (Genomics 2002) 2 3 4 22 64
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice. (PMID: 11113135) Dass B. … MacDonald C.C. (J. Biol. Chem. 2001) 2 3 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for CSTF2T Gene

Sources for CSTF2T Gene

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