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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSTF2 Gene

protein-coding   GIFtS: 61
GCID: GC0XP100075

Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa

(Previous names: cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa1 2     CSTF 64 KDa Subunit2 3
Cleavage Stimulation Factor 64 KDa Subunit2 3     Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kD1
CstF-642 3     BetaCstF-64 Variant 22
CF-1 64 KDa Subunit2 3     Cleavage Stimulation Factor Subunit 22

External Ids:    HGNC: 24841   Entrez Gene: 14782   Ensembl: ENSG000001018117   OMIM: 6003685   UniProtKB: P332403   

Export aliases for CSTF2 gene to outside databases

Previous GC identifers: GC0XP095357 GC0XP097036 GC0XP098111 GC0XP098847 GC0XP099881 GC0XP089874


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSTF2 Gene:
This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the
cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of
pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CSTF2 Gene: 
CSTF2 (cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa) is a protein-coding gene. Diseases associated with CSTF2 include cytomegalovirus infection, and lung cancer, and among its related super-pathways are mRNA Processing and Post-Elongation Processing of Intron-Containing pre-mRNA. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is CSTF2T.

UniProtKB/Swiss-Prot: CSTF2_HUMAN, P33240
Function: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.
This subunit is directly involved in the binding to pre-mRNAs (By similarity)

Gene Wiki entry for CSTF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011651.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSTF2 gene promoter:
         Sox5   AML1a   LCR-F1   C/EBPalpha   PPAR-gamma1   POU2F1   POU2F1a   Cart-1   PPAR-gamma2   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSTF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CSTF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSTF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1

CSTF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSTF2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP100075:  view genomic region     (about GC identifiers)

Start:
100,075,348 bp from pter      End:
100,095,924 bp from pter
Size:
20,577 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CSTF2_HUMAN, P33240 (See protein sequence)
Recommended Name: Cleavage stimulation factor subunit 2  
Size: 577 amino acids; 60959 Da
Subunit: The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa
subunit). CSTF2 directly interacts with CSTF3, SYMPK and RPO2TC1. Interacts with HSF1 in heat-stressed cells.
Interacts with CPSF2, CPSF3 and FIP1L1. Interacts with DDX1
Subcellular location: Nucleus. Note=Localized with DDX1 in cleavage bodies
Sequence caution: Sequence=CAI42681.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for CSTF2:
1P1T (3D)        2J8P (3D)    
Secondary accessions: Q5H951 Q6LA74 Q8N502
Alternative splicing: 2 isoforms:  P33240-1   P33240-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CSTF2: NX_P33240

Explore proteomics data for CSTF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P33240

  • CSTF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CSTF2 Protein Expression
    REFSEQ proteins: NP_001316.1  
    ENSEMBL proteins: 
     ENSP00000362063   ENSP00000432060   ENSP00000415705   ENSP00000387996  
    Reactome Protein details: P33240
    Human Recombinant Protein Products for CSTF2: 
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    Cloud-Clone Corp. Proteins for CSTF2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005847mRNA cleavage and polyadenylation specificity factor complex IDA18305108
    GO:0071920cleavage body IDA11598190

    CSTF2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR026896 CSTF_C
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom
     IPR025742 CSTF2_hinge

    Graphical View of Domain Structure for InterPro Entry P33240

    ProtoNet protein and cluster: P33240

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: CSTF2_HUMAN, P33240
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    CSTF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSTF2_HUMAN, P33240
    Function: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.
    This subunit is directly involved in the binding to pre-mRNAs (By similarity)
    Induction: Up-regulated during the G0 to S phase transition

         Genatlas biochemistry entry for CSTF2:
    cleavage stimulation factor,subunit 2,component of the 3' pre RNA polyadenylation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI10477523
         
    CSTF2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CSTF2:
     Decreased TP53 protein express  Synthetic lethal with c-Myc af 

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CSTF2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA processing0.46
    mRNA Splicing - Major Pathway0.82
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.79
    Post-Elongation Processing of the Transcript0.79
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    3Post-Elongation Processing of Intronless pre-mRNA
    Post-Elongation Processing of Intronless pre-mRNA0.61
    Processing of Capped Intronless Pre-mRNA0.61
    Processing of Intronless Pre-mRNAs0.61
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CSTF2
        Epithelial Tight Junctions

    1 BioSystems Pathway for CSTF2
        mRNA processing

    5/15        Reactome Pathways for CSTF2 (see all 15)
        mRNA Splicing - Major Pathway
    mRNA Splicing
    RNA Polymerase II Transcription
    Transcription
    Cleavage of Growing Transcript in the Termination Region


    1         Kegg Pathway  (Kegg details for CSTF2):
        mRNA surveillance pathway


    CSTF2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSTF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/125 Interacting proteins for CSTF2 (P332401, 2, 3 ENSP000003620634) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF2Q9P2I02, 3, ENSP000002988754MINT-6802591 MINT-6802639 MINT-6802510 MINT-6802560 MINT-6802545 MINT-6802527 MINT-8089129 I2D: score=2 STRING: ENSP00000298875
    BAG6P463792, 3MINT-63680 I2D: score=5 
    ENSG00000096155P463792, 3MINT-63680 I2D: score=5 
    ENSG00000227761P463792, 3MINT-63680 I2D: score=5 
    ENSG00000228760P463792, 3MINT-63680 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006378mRNA polyadenylation TAS1741396
    GO:0006379mRNA cleavage TAS1741396

    CSTF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CSTF2

    Search CenterWatch for drugs/clinical trials and news about CSTF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CSTF2 gene: 
    NM_001325.2  

    Unigene Cluster for CSTF2:

    Cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa
    Hs.132370  [show with all ESTs]
    Unigene Representative Sequence: AK300600
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372972 ENST00000486615 ENST00000475126 ENST00000413437 ENST00000415585(uc004egh.3 uc010nnd.3 uc004egi.3)

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    Additional mRNA sequence: 

    AK095684.1 AK300600.1 BC017712.1 BC033135.1 BT009778.1 EU616679.1 M85085.1 

    8 DOTS entries:

    DT.212221  DT.100798009  DT.100691949  DT.99937530  DT.70101699  DT.100798008  DT.121283460  DT.91719867 

    24/191 AceView cDNA sequences (see all 191):

    BF063389 BU157798 BQ431827 BC017712 NM_001325 AL530885 AI357676 BF431014 
    CD742962 BM041999 CB241553 CR603621 CR593825 BM852311 BX380436 CR617742 
    BM727546 BM681761 BQ880371 BE048916 AA504518 BU181005 BU633840 CR598613 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CSTF2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b
    SP1:                    -                 -                                                     -                                         -               
    SP2:                    -                 -                                   -                 -                                         -               
    SP3:                    -                 -     -                                                                                                         
    SP4:                                      -                                                                                                               
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for CSTF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSTF2 expression in normal human tissues (normalized intensities)      CSTF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CSTF2 Expression
    About this image


    CSTF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See CSTF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSTF2

    SOURCE GeneReport for Unigene cluster: Hs.132370
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSTF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSTF2 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cstf21 , 5 cleavage stimulation factor, 3' pre-RNA subunit 21, 5 89.49(n)1
    93.76(a)1
      X (55.63 cM)5
    1080621  NM_133196.51  NP_573459.11 
     1340591875 
    chicken
    (Gallus gallus)
    Aves CSTF21 cleavage stimulation factor, 3' pre-RNA, subunit 2, more 74.46(n)
    82.4(a)
      422258  NM_001006433.1  NP_001006433.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041291.12   -- 73.91(n)    BC041291.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb11e072 wufb11e07 74.43(n)   386806  BC046091.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CstF-643 mRNA cleavage RNA binding 65(a)   91B8   --
    worm
    (Caenorhabditis elegans)
    Secernentea R06C1.46
    R09B3.26
    (see all 4)
    Protein R09B3.2
    (see all 4)
    46(a)
    45(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    I(11930725-11931759)
    I(11909356-11910104)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YGR250C)4 Putative RNA binding protein; localizes to stress granules more   --   7(993521-991176) 853165  NP_011766.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CSTF641 cleavage stimulating factor 64 48.48(n)
    40.06(a)
      843510  NM_105838.4  NP_177325.2 
    rice
    (Oryza sativa)
    Liliopsida Os.218092 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 80.28(n)    AK067921.1 


    ENSEMBL Gene Tree for CSTF2 (if available)
    TreeFam Gene Tree for CSTF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSTF2 gene
    CSTF2T2  RBMX22  
    8 SIMAP similar genes for CSTF2 using alignment to 4 protein entries:     CSTF2_HUMAN (see all proteins):
    CSTF2T    SNRNP70    HNRNPD    RBMY1A1    TIAL1    RBM3
    RBMX2    ELAVL2

    CSTF2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CSTF2
    PGOHUM00000261853


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/318 SNPs in CSTF2 are shown (see all 318)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs789638851,2
    F--89873110(+) GGCACA/GTGCCA 1 -- us2k13Minor allele frequency- G:0.38NA 8
    rs1387373691,2
    C--89895087(+) AACATA/GTATAA 1 -- ds50010--------
    rs1876527171,2
    --89895089(+) CATGTA/GTAATT 1 -- ds50010--------
    rs1488209561,2
    C--100039664(+) TGTAAA/GAAGGC 1 -- us2k10--------
    rs1826340351,2
    --100039697(+) AGGCTA/GGCAGT 1 -- us2k10--------
    rs8754501,2
    C,F,A,H--100039791(+) ATTCAA/GTGGGG 1 -- us2k1 tfbs316Minor allele frequency- G:0.35NS EA NA WA CSA 1804
    rs1873303411,2
    --100039824(+) TGCCTG/TGGACA 1 -- us2k10--------
    rs1911514781,2
    --100039829(+) TGGACA/GTGGCA 1 -- us2k10--------
    rs1830345821,2
    --100039960(+) AAGGGA/TAATTT 1 -- us2k10--------
    rs1464544111,2
    C--100040061(+) CAGTGA/GCACTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CSTF2 (100075348 - 100095924 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CSTF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510850CNV Loss20534489


    Locus Specific Mutation Databases (LSDB): CSTF2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CSTF2
    DNA2.0 Custom Variant and Variant Library Synthesis for CSTF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600368    OMIM disorders: --

    3 diseases for CSTF2:    About MalaCards
    cytomegalovirus infection    lung cancer    sarcoma


    CSTF2 for disorders           About GeneDecksing


    Export disorders for CSTF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSTF2 gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with CSTF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs. (PubMed id 1741396)1, 2, 3 Takagaki Y.... Manley J.L. (1992)
    2. Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition. (PubMed id 9736695)1, 2, 9 Martincic K....Milcarek C. (1998)
    3. RNA recognition by the human polyadenylation factor CstF. (PubMed id 9199325)1, 2, 9 Takagaki Y. and Manley J.L. (1997)
    4. Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA. (PubMed id 11598190)1, 2, 9 Bleoo S....Godbout R. (2001)
    5. Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. (PubMed id 11389848)1, 2, 9 Calvo O. and Manley J.L. (2001)
    6. Complex protein interactions within the human polyadenylation machinery identify a novel component. (PubMed id 10669729)1, 2, 9 Takagaki Y. and Manley J.L. (2000)
    7. Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3'-end maturation. (PubMed id 18688255)1, 2 Kolev N.G.... Steitz J.A. (2008)
    8. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    9. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PubMed id 14749727)1, 2 Kaufmann I.... Keller W. (2004)
    10. HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. (PubMed id 14707147)1, 2 Xing H.... Sarge K.D. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1478 HGNC: 2484 AceView: CSTF2 Ensembl:ENSG00000101811 euGenes: HUgn1478
    ECgene: CSTF2 Kegg: 1478 H-InvDB: CSTF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSTF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CSTF2 gene:
    Search GeneIP for patents involving CSTF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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