Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CSTF2 Gene

Aliases for CSTF2 Gene

  • Cleavage Stimulation Factor Subunit 2 2
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 2 2 3 5
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 2, 64kD 2 3
  • Cleavage Stimulation Factor 64 KDa Subunit 3 4
  • CF-1 64 KDa Subunit 3 4
  • CSTF 64 KDa Subunit 3 4
  • CstF-64 3 4
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 2, 64kDa 3
  • BetaCstF-64 Variant 2 3

External Ids for CSTF2 Gene

Previous GeneCards Identifiers for CSTF2 Gene

  • GC0XP095357
  • GC0XP097036
  • GC0XP098111
  • GC0XP098847
  • GC0XP099881
  • GC0XP100075
  • GC0XP089874

Summaries for CSTF2 Gene

Entrez Gene Summary for CSTF2 Gene

  • This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSTF2 Gene

CSTF2 (Cleavage Stimulation Factor Subunit 2) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CSTF2T.

UniProtKB/Swiss-Prot for CSTF2 Gene

  • One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).

Gene Wiki entry for CSTF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSTF2 Gene

Genomics for CSTF2 Gene

Regulatory Elements for CSTF2 Gene

Enhancers for CSTF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CSTF2 on UCSC Golden Path with GeneCards custom track

Promoters for CSTF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CSTF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CSTF2 Gene

Chromosome:
X
Start:
100,820,359 bp from pter
End:
100,841,520 bp from pter
Size:
21,162 bases
Orientation:
Plus strand

Genomic View for CSTF2 Gene

Genes around CSTF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSTF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSTF2 Gene

Proteins for CSTF2 Gene

  • Protein details for CSTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33240-CSTF2_HUMAN
    Recommended name:
    Cleavage stimulation factor subunit 2
    Protein Accession:
    P33240
    Secondary Accessions:
    • Q5H951
    • Q6LA74
    • Q8N502

    Protein attributes for CSTF2 Gene

    Size:
    577 amino acids
    Molecular mass:
    60959 Da
    Quaternary structure:
    • The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF2 directly interacts with CSTF3, SYMPK and RPO2TC1. Interacts with HSF1 in heat-stressed cells. Interacts with CPSF2, CPSF3 and FIP1L1. Interacts with DDX1.
    SequenceCaution:
    • Sequence=CAI42681.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CSTF2 Gene

    Alternative splice isoforms for CSTF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSTF2 Gene

Proteomics data for CSTF2 Gene at MOPED

Post-translational modifications for CSTF2 Gene

  • Ubiquitination at Lys 148, Lys 189, and Lys 572
  • Modification sites at PhosphoSitePlus

Other Protein References for CSTF2 Gene

No data available for DME Specific Peptides for CSTF2 Gene

Domains & Families for CSTF2 Gene

Gene Families for CSTF2 Gene

Graphical View of Domain Structure for InterPro Entry

P33240

UniProtKB/Swiss-Prot:

CSTF2_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with CSTF2: view

Function for CSTF2 Gene

Molecular function for CSTF2 Gene

GENATLAS Biochemistry:
cleavage stimulation factor,subunit 2,component of the 3 pre RNA polyadenylation
UniProtKB/Swiss-Prot Function:
One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated during the G0 to S phase transition.

Gene Ontology (GO) - Molecular Function for CSTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding TAS 1741396
GO:0003729 mRNA binding IBA --
genes like me logo Genes that share ontologies with CSTF2: view
genes like me logo Genes that share phenotypes with CSTF2: view

Animal Model Products

miRNA for CSTF2 Gene

miRTarBase miRNAs that target CSTF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSTF2 Gene

Localization for CSTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSTF2 Gene

Nucleus. Note=Localized with DDX1 in cleavage bodies.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSTF2 Gene COMPARTMENTS Subcellular localization image for CSTF2 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071920 cleavage body IDA 11598190
genes like me logo Genes that share ontologies with CSTF2: view

Pathways & Interactions for CSTF2 Gene

genes like me logo Genes that share pathways with CSTF2: view

Pathways by source for CSTF2 Gene

1 KEGG pathway for CSTF2 Gene
1 Qiagen pathway for CSTF2 Gene

Gene Ontology (GO) - Biological Process for CSTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IEA,TAS --
GO:0006379 mRNA cleavage TAS 1741396
genes like me logo Genes that share ontologies with CSTF2: view

No data available for SIGNOR curated interactions for CSTF2 Gene

Drugs & Compounds for CSTF2 Gene

No Compound Related Data Available

Transcripts for CSTF2 Gene

Unigene Clusters for CSTF2 Gene

Cleavage stimulation factor, 3 pre-RNA, subunit 2, 64kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSTF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5:
SP6: - - - - - - - -
SP7: -

Relevant External Links for CSTF2 Gene

GeneLoc Exon Structure for
CSTF2
ECgene alternative splicing isoforms for
CSTF2

Expression for CSTF2 Gene

mRNA expression in normal human tissues for CSTF2 Gene

Protein differential expression in normal tissues from HIPED for CSTF2 Gene

This gene is overexpressed in Liver (48.3) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSTF2 Gene



SOURCE GeneReport for Unigene cluster for CSTF2 Gene Hs.132370

genes like me logo Genes that share expression patterns with CSTF2: view

Protein tissue co-expression partners for CSTF2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSTF2 Gene

Orthologs for CSTF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSTF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSTF2 35
  • 92.25 (n)
  • 95.98 (a)
CSTF2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSTF2 35
  • 92.72 (n)
  • 96.36 (a)
CSTF2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cstf2 35
  • 89.49 (n)
  • 93.76 (a)
Cstf2 16
Cstf2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSTF2 35
  • 99.94 (n)
  • 100 (a)
CSTF2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cstf2 35
  • 90.44 (n)
  • 94.06 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves CSTF2 35
  • 74.46 (n)
  • 82.4 (a)
CSTF2 36
  • 77 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cstf2 35
  • 71.84 (n)
  • 78.98 (a)
Str.5893 35
zebrafish
(Danio rerio)
Actinopterygii LOC100534697 35
  • 70.76 (n)
  • 76.27 (a)
wufb11e07 35
cstf2 36
  • 69 (a)
ManyToMany
cstf2 36
  • 69 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7345 35
fruit fly
(Drosophila melanogaster)
Insecta CstF-64 37
  • 65 (a)
CstF-64 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpf-2 36
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IST3 36
  • 22 (a)
OneToMany
-- 38
rice
(Oryza sativa)
Liliopsida Os.21809 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for CSTF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSTF2 Gene

ENSEMBL:
Gene Tree for CSTF2 (if available)
TreeFam:
Gene Tree for CSTF2 (if available)

Paralogs for CSTF2 Gene

Paralogs for CSTF2 Gene

(8) SIMAP similar genes for CSTF2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CSTF2 Gene

genes like me logo Genes that share paralogs with CSTF2: view

Variants for CSTF2 Gene

Sequence variations from dbSNP and Humsavar for CSTF2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747717349 -- 100,820,783(+) GTACT(A/G)CTTCT intron-variant
rs747731267 -- 100,825,772(+) CAACC(A/C)CTGCT intron-variant
rs748011738 -- 100,828,048(+) GAATG(C/T)AGGCT reference, stop-gained
rs748045325 -- 100,840,967(+) AAAAA(C/G)CTTAA downstream-variant-500B, utr-variant-3-prime
rs748167665 -- 100,833,339(+) AATGG(A/C)AGTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CSTF2 Gene

Variant ID Type Subtype PubMed ID
nsv510850 CNV Loss 20534489

Variation tolerance for CSTF2 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSTF2 Gene

HapMap Linkage Disequilibrium report
CSTF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSTF2 Gene

Disorders for CSTF2 Gene

Relevant External Links for CSTF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSTF2

No disorders were found for CSTF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSTF2 Gene

Publications for CSTF2 Gene

  1. The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs. (PMID: 1741396) Takagaki Y. … Manley J.L. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 67
  2. The hinge domain of the cleavage stimulation factor protein CstF-64 is essential for CstF-77 interaction, nuclear localization, and polyadenylation. (PMID: 19887456) Hockert J.A. … MacDonald C.C. (J. Biol. Chem. 2010) 3 23
  3. Protein and RNA dynamics play key roles in determining the specific recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein. (PMID: 15769465) Deka P. … Varani G. (J. Mol. Biol. 2005) 3 23
  4. Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA. (PMID: 11598190) Bleoo S. … Godbout R. (Mol. Biol. Cell 2001) 3 23
  5. Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. (PMID: 11389848) Calvo O. … Manley J.L. (Mol. Cell 2001) 3 23

Products for CSTF2 Gene

Sources for CSTF2 Gene

Content