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CSTF2 Gene

protein-coding   GIFtS: 63
GCID: GC0XP100075

Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa

(Previous names: cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kD)
  See CSTF2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa1 2     Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kD1
Cleavage Stimulation Factor 64 KDa Subunit2 3     BetaCstF-64 Variant 22
CstF-642 3     Cleavage Stimulation Factor Subunit 22
CF-1 64 KDa Subunit2 3     CSTF645
CSTF 64 KDa Subunit2 3     

External Ids:    HGNC: 24841   Entrez Gene: 14782   Ensembl: ENSG000001018117   OMIM: 3009075   UniProtKB: P332403   
ORGUL members:         

Export aliases for CSTF2 gene to outside databases

Previous GC identifers: GC0XP095357 GC0XP097036 GC0XP098111 GC0XP098847 GC0XP099881 GC0XP089874


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSTF2 Gene:
This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the
cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of
pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CSTF2 Gene:
CSTF2 (cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa) is a protein-coding gene. Diseases associated with CSTF2 include cytomegalovirus infection. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is CSTF2T.

UniProtKB/Swiss-Prot: CSTF2_HUMAN, P33240
Function: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.
This subunit is directly involved in the binding to pre-mRNAs (By similarity)

Gene Wiki entry for CSTF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSTF2 gene promoter:
         Sox5   AML1a   LCR-F1   C/EBPalpha   PPAR-gamma1   POU2F1   POU2F1a   Cart-1   PPAR-gamma2   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSTF2 promoter sequence
   Search Chromatin IP Primers for CSTF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSTF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1

CSTF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSTF2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP100075:  view genomic region     (about GC identifiers)

Start:
100,075,348 bp from pter      End:
100,095,924 bp from pter
Size:
20,577 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CSTF2_HUMAN, P33240 (See protein sequence)
Recommended Name: Cleavage stimulation factor subunit 2  
Size: 577 amino acids; 60959 Da
Subunit: The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa
subunit). CSTF2 directly interacts with CSTF3, SYMPK and RPO2TC1. Interacts with HSF1 in heat-stressed cells.
Interacts with CPSF2, CPSF3 and FIP1L1. Interacts with DDX1
Sequence caution: Sequence=CAI42681.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for CSTF2:
1P1T (3D)        2J8P (3D)    
Secondary accessions: Q5H951 Q6LA74 Q8N502
Alternative splicing: 2 isoforms:  P33240-1   P33240-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CSTF2: NX_P33240

Explore proteomics data for CSTF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys148, Lys189, Lys572
  • Modification sites at PhosphoSitePlus

  • See CSTF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001316.1  
    ENSEMBL proteins: 
     ENSP00000362063   ENSP00000432060   ENSP00000415705   ENSP00000387996  
    Reactome Protein details: P33240

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR026896 CSTF_C
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom
     IPR025742 CSTF2_hinge

    Graphical View of Domain Structure for InterPro Entry P33240

    ProtoNet protein and cluster: P33240

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: CSTF2_HUMAN, P33240
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with CSTF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSTF2_HUMAN, P33240
    Function: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.
    This subunit is directly involved in the binding to pre-mRNAs (By similarity)
    Induction: Up-regulated during the G0 to S phase transition

         Genatlas biochemistry entry for CSTF2:
    cleavage stimulation factor,subunit 2,component of the 3' pre RNA polyadenylation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS1741396
    GO:0005515protein binding IPI10477523
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CSTF2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CSTF2:
     Decreased TP53 protein express  Synthetic lethal with c-Myc af 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CSTF2

    miRNA
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    hsa-mir-375 (MIRT019784), hsa-mir-149-5p (MIRT045489)

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    5 qRT-PCR Assays for microRNAs that regulate CSTF2:
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    SwitchGear 3'UTR luciferase reporter plasmidCSTF2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CSTF2_HUMAN, P33240: Nucleus. Note=Localized with DDX1 in cleavage bodies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005847mRNA cleavage and polyadenylation specificity factor complex IDA18305108
    GO:0071920cleavage body IDA11598190

    Find genes that share ontologies with CSTF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSTF2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    Processing of Capped Intronless Pre-mRNA0.52
    Cleavage of Growing Transcript in the Termination Region0.80
    Processing of Intronless Pre-mRNAs0.00
    mRNA 3-end processing0.80
    3Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    4Gene Expression
    Gene Expression0.40
    5Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36


    Find genes that share SuperPaths with CSTF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CSTF2
        Epithelial Tight Junctions

    1 BioSystems Pathway for CSTF2
        mRNA processing

    4 Reactome Pathways for CSTF2
        mRNA Splicing - Major Pathway
    mRNA 3'-end processing
    Processing of Intronless Pre-mRNAs
    Cleavage of Growing Transcript in the Termination Region


    1 Kegg Pathway  (Kegg details for CSTF2):
        mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSTF2
    Interactions:

        GeneGlobe Interaction Network for CSTF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSTF2 (P332401, 2, 3 ENSP000003620634) via UniProtKB, MINT, STRING, and/or I2D (see all 218)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF2Q9P2I01, 2, 3, ENSP000002988754EBI-711360,EBI-1043224 MINT-6802591 MINT-6802639 MINT-6802510 MINT-6802560 MINT-6802545 MINT-6802527 MINT-8089129 I2D: score=2 STRING: ENSP00000298875
    PARNO954531, 2, 3, ENSP000003879114EBI-711360,EBI-372832 MINT-7898660 MINT-7898677 MINT-7898584 MINT-7898703 MINT-7898597 MINT-7898644 I2D: score=1 STRING: ENSP00000387911
    BAG6P463792, 3MINT-63680 I2D: score=5 
    ENSG00000096155P463792, 3MINT-63680 I2D: score=5 
    ENSG00000227761P463792, 3MINT-63680 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006378mRNA polyadenylation TAS1741396
    GO:0006379mRNA cleavage TAS1741396

    Find genes that share ontologies with CSTF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for CSTF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CSTF2 gene: 
    NM_001325.2  

    Unigene Cluster for CSTF2:

    Cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa
    Hs.132370  [show with all ESTs]
    Unigene Representative Sequence: AK300600
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372972 ENST00000475126 ENST00000413437 ENST00000415585(uc004egh.3 uc010nnd.3 uc004egi.3)

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    hsa-miR-221* hsa-miR-124* hsa-miR-224 hsa-miR-561 hsa-miR-205*
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    Additional mRNA sequence: 

    AK095684.1 AK300600.1 BC017712.1 BC033135.1 BT009778.1 EU616679.1 M85085.1 

    8 DOTS entries:

    DT.212221  DT.100798009  DT.100691949  DT.99937530  DT.70101699  DT.100798008  DT.121283460  DT.91719867 

    Selected AceView cDNA sequences (see all 191):

    CR594312 CD742962 CB157874 BX380436 BM852311 BC033135 CR617742 AL530885 
    AA504518 BU181005 CR603621 BC017712 CB241553 BM915506 BG763866 BG576992 
    BX341914 BM727546 CR614161 BM549462 BF431014 AI816047 CA426501 AW662212 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CSTF2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b
    SP1:                    -                 -                                                     -                                         -               
    SP2:                    -                 -                                   -                 -                                         -               
    SP3:                    -                 -     -                                                                                                         
    SP4:                                      -                                                                                                               
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for CSTF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSTF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CSTF2 Expression
    About this image


    CSTF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    CSTF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSTF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132370
        Custom PCR Arrays for CSTF2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSTF2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cstf21 , 5 cleavage stimulation factor, 3' pre-RNA subunit 21, 5 89.49(n)1
    93.76(a)1
      X (55.63 cM)5
    1080621  NM_133196.51  NP_573459.11 
     1340591875 
    chicken
    (Gallus gallus)
    Aves CSTF21 cleavage stimulation factor, 3' pre-RNA, subunit 2, more 74.46(n)
    82.4(a)
      422258  NM_001006433.2  NP_001006433.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041291.12   -- 73.91(n)    BC041291.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb11e072 wufb11e07 74.43(n)   386806  BC046091.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CstF-643 mRNA cleavage RNA binding 65(a)   91B8   --
    worm
    (Caenorhabditis elegans)
    Secernentea cpf-26
    Protein CPF-2 (cpf-2) mRNA, complete cds
    41(a)
    1 → many
    III(13266940-13268897) WBGene00000774
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YGR250C)4 Putative RNA binding protein; localizes to stress granules more   --   7(993521-991176) 853165  NP_011766.1 
    rice
    (Oryza sativa)
    Liliopsida Os.218092 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 80.28(n)    AK067921.1 


    ENSEMBL Gene Tree for CSTF2 (if available)
    TreeFam Gene Tree for CSTF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSTF2 gene
    CSTF2T2  RBMX22  
    8 SIMAP similar genes for CSTF2 using alignment to 4 protein entries:     CSTF2_HUMAN (see all proteins):
    CSTF2T    SNRNP70    HNRNPD    RBMY1A1    TIAL1    RBM3
    RBMX2    ELAVL2

    Find genes that share paralogs with CSTF2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CSTF2
    PGOHUM00000261853


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSTF2 (see all 318)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs789638851,2
    F--89873110(+) GGCACA/GTGCCA 1 -- us2k13Minor allele frequency- G:0.38NA 8
    rs1387373691,2
    C--89895087(+) AACATA/GTATAA 1 -- ds50010--------
    rs1876527171,2
    --89895089(+) CATGTA/GTAATT 1 -- ds50010--------
    rs1488209561,2
    C--100039664(+) TGTAAA/GAAGGC 1 -- us2k10--------
    rs1826340351,2
    --100039697(+) AGGCTA/GGCAGT 1 -- us2k10--------
    rs8754501,2
    C,F,A,H--100039791(+) ATTCAA/GTGGGG 1 -- us2k1 tfbs316Minor allele frequency- G:0.35NS EA NA WA CSA 1804
    rs1873303411,2
    --100039824(+) TGCCTG/TGGACA 1 -- us2k10--------
    rs1911514781,2
    --100039829(+) TGGACA/GTGGCA 1 -- us2k10--------
    rs1830345821,2
    --100039960(+) AAGGGA/TAATTT 1 -- us2k10--------
    rs1464544111,2
    C--100040061(+) CAGTGA/GCACTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CSTF2 (100075348 - 100095924 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CSTF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510850CNV Loss20534489

    Locus Specific Mutation Databases (LSDB): CSTF2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSTF2
    DNA2.0 Custom Variant and Variant Library Synthesis for CSTF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300907    OMIM disorders: --

    1 disease for CSTF2:    
    About MalaCards
    cytomegalovirus infection


    Find genes that share disorders with CSTF2           About GenesLikeMe


    Export disorders for CSTF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSTF2 gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with CSTF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs. (PubMed id 1741396)1, 2, 3 Takagaki Y.... Manley J.L. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition. (PubMed id 9736695)1, 2, 9 Martincic K....Milcarek C. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. RNA recognition by the human polyadenylation factor CstF. (PubMed id 9199325)1, 2, 9 Takagaki Y. and Manley J.L. (Mol. Cell. Biol. 1997)
    4. Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA. (PubMed id 11598190)1, 2, 9 Bleoo S.... Godbout R. (Mol. Biol. Cell 2001)
    5. Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. (PubMed id 11389848)1, 2, 9 Calvo O. and Manley J.L. (Mol. Cell 2001)
    6. Complex protein interactions within the human polyadenylation machinery identify a novel component. (PubMed id 10669729)1, 2, 9 Takagaki Y. and Manley J.L. (Mol. Cell. Biol. 2000)
    7. Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3'-end maturation. (PubMed id 18688255)1, 2 Kolev N.G.... Steitz J.A. (EMBO Rep. 2008)
    8. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    9. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PubMed id 14749727)1, 2 Kaufmann I.... Keller W. (EMBO J. 2004)
    10. HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. (PubMed id 14707147)1, 2 Xing H.... Sarge K.D. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1478 HGNC: 2484 AceView: CSTF2 Ensembl:ENSG00000101811 euGenes: HUgn1478
    ECgene: CSTF2 Kegg: 1478 H-InvDB: CSTF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CSTF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CSTF2 gene:
    Search GeneIP for patents involving CSTF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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