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Aliases for CSTF1 Gene

Aliases for CSTF1 Gene

  • Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 1, 50kDa 2
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 1, 50kDa 2 3
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 1, 50kD 2 3
  • Cleavage Stimulation Factor 50 KDa Subunit 3 4
  • CF-1 50 KDa Subunit 3 4
  • CSTF 50 KDa Subunit 3 4
  • CstF-50 3 4
  • CstFp50 3

External Ids for CSTF1 Gene

Previous GeneCards Identifiers for CSTF1 Gene

  • GC20P054696
  • GC20P055605
  • GC20P055653
  • GC20P054401
  • GC20P054967
  • GC20P051752

Summaries for CSTF1 Gene

Entrez Gene Summary for CSTF1 Gene

  • This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSTF1 Gene

CSTF1 (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 1, 50kDa) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and RNA binding. An important paralog of this gene is PRPF4.

UniProtKB/Swiss-Prot for CSTF1 Gene

  • One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA

Gene Wiki entry for CSTF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSTF1 Gene

Genomics for CSTF1 Gene

Regulatory Elements for CSTF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CSTF1 Gene

Chromosome:
20
Start:
56,392,371 bp from pter
End:
56,406,369 bp from pter
Size:
13,999 bases
Orientation:
Plus strand

Genomic View for CSTF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for CSTF1 Gene

Proteins for CSTF1 Gene

  • Protein details for CSTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05048-CSTF1_HUMAN
    Recommended name:
    Cleavage stimulation factor subunit 1
    Protein Accession:
    Q05048
    Secondary Accessions:
    • Q5QPD8

    Protein attributes for CSTF1 Gene

    Size:
    431 amino acids
    Molecular mass:
    48358 Da
    Quaternary structure:
    • Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts directly with CSTF3. Interacts with BARD1.
    SequenceCaution:
    • Sequence=CAC12718.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CSTF1 Gene

Proteomics data for CSTF1 Gene at MOPED

Post-translational modifications for CSTF1 Gene

Antibody Products

No data available for DME Specific Peptides for CSTF1 Gene

Domains & Families for CSTF1 Gene

Gene Families for CSTF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q05048

UniProtKB/Swiss-Prot:

CSTF1_HUMAN :
  • The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with CSTF3
  • Contains 6 WD repeats.
Domain:
  • The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with CSTF3
  • N-terminus mediates homodimerization
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with CSTF1: view

Function for CSTF1 Gene

Molecular function for CSTF1 Gene

GENATLAS Biochemistry:
cleavage stimulation factor,subunit 1,component of the 3 pre-RNA polyadenylation, homolog to the G protein beta-subunit
UniProtKB/Swiss-Prot Function:
One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA

Gene Ontology (GO) - Molecular Function for CSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 1741396
GO:0005515 protein binding IPI 10477523
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CSTF1: view
genes like me logo Genes that share phenotypes with CSTF1: view

Animal Model Products

miRNA for CSTF1 Gene

miRTarBase miRNAs that target CSTF1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CSTF1 Gene

Localization for CSTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSTF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSTF1 Gene COMPARTMENTS Subcellular localization image for CSTF1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CSTF1: view

Pathways & Interactions for CSTF1 Gene

genes like me logo Genes that share pathways with CSTF1: view

Gene Ontology (GO) - Biological Process for CSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation TAS 1358884
GO:0006379 mRNA cleavage TAS 1358884
genes like me logo Genes that share ontologies with CSTF1: view

No data available for SIGNOR curated interactions for CSTF1 Gene

Drugs & Compounds for CSTF1 Gene

No Compound Related Data Available

Transcripts for CSTF1 Gene

Unigene Clusters for CSTF1 Gene

Cleavage stimulation factor, 3 pre-RNA, subunit 1, 50kDa:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSTF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSTF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - -
SP9: - - - - - -
SP10: - - - - - - - - - -
SP11: - - - -
SP12: - -

ExUns: 9c · 9d ^ 10
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CSTF1 Gene

GeneLoc Exon Structure for
CSTF1
ECgene alternative splicing isoforms for
CSTF1

Expression for CSTF1 Gene

mRNA expression in normal human tissues for CSTF1 Gene

Protein differential expression in normal tissues from HIPED for CSTF1 Gene

This gene is overexpressed in Breast (34.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSTF1 Gene



SOURCE GeneReport for Unigene cluster for CSTF1 Gene Hs.172865

genes like me logo Genes that share expression patterns with CSTF1: view

Protein tissue co-expression partners for CSTF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSTF1 Gene

Orthologs for CSTF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSTF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSTF1 35
  • 89.64 (n)
  • 99.54 (a)
CSTF1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSTF1 35
  • 91.57 (n)
  • 99.77 (a)
CSTF1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cstf1 35
  • 87.01 (n)
  • 99.54 (a)
Cstf1 16
Cstf1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSTF1 35
  • 99.3 (n)
  • 100 (a)
CSTF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cstf1 35
  • 87.24 (n)
  • 99.54 (a)
oppossum
(Monodelphis domestica)
Mammalia CSTF1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSTF1 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves CSTF1 35
  • 80.74 (n)
  • 98.14 (a)
CSTF1 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSTF1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cstf1 35
  • 76.57 (n)
  • 95.13 (a)
Str.6242 35
African clawed frog
(Xenopus laevis)
Amphibia cstf1-prov 35
zebrafish
(Danio rerio)
Actinopterygii cstf1 35
  • 73.64 (n)
  • 83.64 (a)
wufc22d10 35
cstf1 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CstF-50 37
  • 55 (a)
CstF-50 35
  • 57.8 (n)
  • 56.59 (a)
CstF-50 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002776 35
  • 56.39 (n)
  • 58.5 (a)
worm
(Caenorhabditis elegans)
Secernentea cpf-1 35
  • 54.85 (n)
  • 53.19 (a)
cpf-1 36
  • 52 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP4 36
  • 15 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60940 35
  • 48.41 (n)
  • 39.95 (a)
rice
(Oryza sativa)
Liliopsida Os03g0754900 35
  • 50.55 (n)
  • 41.06 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14049 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5452 36
  • 60 (a)
OneToOne
Species with no ortholog for CSTF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSTF1 Gene

ENSEMBL:
Gene Tree for CSTF1 (if available)
TreeFam:
Gene Tree for CSTF1 (if available)

Paralogs for CSTF1 Gene

Paralogs for CSTF1 Gene

genes like me logo Genes that share paralogs with CSTF1: view

Variants for CSTF1 Gene

Sequence variations from dbSNP and Humsavar for CSTF1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs7806 -- 56,404,115(+) TTTCC(C/T)TTCCA utr-variant-3-prime
rs1884911 -- 56,401,144(+) TAAAA(A/C)CAATA intron-variant
rs1884912 -- 56,401,332(+) AGAAA(A/C)GGTGG intron-variant
rs2426617 -- 56,399,368(+) TGAGA(A/C)GTTGA intron-variant
rs2426618 -- 56,399,584(+) CTCAC(A/G)CCGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSTF1 Gene

Variant ID Type Subtype PubMed ID
nsv834013 CNV Gain 17160897
nsv525425 CNV Gain 19592680

Variation tolerance for CSTF1 Gene

Residual Variation Intolerance Score: 11.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSTF1 Gene

HapMap Linkage Disequilibrium report
CSTF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSTF1 Gene

Disorders for CSTF1 Gene

Relevant External Links for CSTF1

Genetic Association Database (GAD)
CSTF1
Human Genome Epidemiology (HuGE) Navigator
CSTF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSTF1
genes like me logo Genes that share disorders with CSTF1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSTF1 Gene

Publications for CSTF1 Gene

  1. Nuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damage. (PMID: 20379136) Cevher M.A. … Kleiman F.E. (EMBO J. 2010) 23 67
  2. The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50. (PMID: 18842000) Edwards R.A. … Glover J.N. (Biochemistry 2008) 23 67
  3. The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. (PMID: 11257228) Kleiman F.E. … Manley J.L. (Cell 2001) 2 67
  4. Complex protein interactions within the human polyadenylation machinery identify a novel component. (PMID: 10669729) Takagaki Y. … Manley J.L. (Mol. Cell. Biol. 2000) 23 67
  5. A human polyadenylation factor is a G protein beta-subunit homologue. (PMID: 1358884) Takagaki Y. … Manley J.L. (J. Biol. Chem. 1992) 2 67

Products for CSTF1 Gene

Sources for CSTF1 Gene

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