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CSTF1 Gene

protein-coding   GIFtS: 63
GCID: GC20P054967

Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 1, 50kDa

(Previous names: cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kD)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 1, 50kDa1 2     CSTF 50 KDa Subunit2 3
Cleavage Stimulation Factor 50 KDa Subunit2 3     Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 1, 50kD1
CstF-502 3     CstFp502
CF-1 50 KDa Subunit2 3     Cleavage Stimulation Factor Subunit 12

External Ids:    HGNC: 24831   Entrez Gene: 14772   Ensembl: ENSG000001011387   OMIM: 6003695   UniProtKB: Q050483   

Export aliases for CSTF1 gene to outside databases

Previous GC identifers: GC20P054696 GC20P055605 GC20P055653 GC20P054401 GC20P051752


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSTF1 Gene:
This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved
in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this
protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the
same protein, have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CSTF1 Gene:
CSTF1 (cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa) is a protein-coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is PRPF19.

UniProtKB/Swiss-Prot: CSTF1_HUMAN, Q05048
Function: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May
be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA

Gene Wiki entry for CSTF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSTF1 gene promoter:
         NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSTF1 promoter sequence
   Search Chromatin IP Primers for CSTF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSTF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.2   HGNC cytogenetic band: 20q13.31

CSTF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSTF1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P054967:  view genomic region     (about GC identifiers)

Start:
54,967,427 bp from pter      End:
54,979,582 bp from pter
Size:
12,156 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CSTF1_HUMAN, Q05048 (See protein sequence)
Recommended Name: Cleavage stimulation factor subunit 1  
Size: 431 amino acids; 48358 Da
Subunit: Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77
kDa subunit). Interacts directly with CSTF3. Interacts with BARD1
Sequence caution: Sequence=CAC12718.2; Type=Erroneous gene model prediction;
Secondary accessions: Q5QPD8

Explore the universe of human proteins at neXtProt for CSTF1: NX_Q05048

Explore proteomics data for CSTF1 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CSTF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001028693.1  NP_001028694.1  NP_001315.1  

    ENSEMBL proteins: 
     ENSP00000387968   ENSP00000217109   ENSP00000405171   ENSP00000409035  
    Reactome Protein details: Q05048

    CSTF1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q05048

    ProtoNet protein and cluster: Q05048

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: CSTF1_HUMAN, Q05048
    Domain: The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with
    CSTF3
    Domain: N-terminus mediates homodimerization
    Similarity: Contains 6 WD repeats


    Find genes that share domains with CSTF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSTF1_HUMAN, Q05048
    Function: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May
    be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA

         Genatlas biochemistry entry for CSTF1:
    cleavage stimulation factor,subunit 1,component of the 3' pre-RNA polyadenylation, homolog to the G protein
    beta-subunit

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS1741396
    GO:0005515protein binding IPI10477523
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CSTF1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CSTF1:
     Increased 8N DNA content  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

    Animal Models:
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    hsa-miR-4303 hsa-miR-3200-5p hsa-miR-361-5p hsa-miR-499-3p hsa-miR-548b-3p hsa-miR-1257 hsa-miR-3692 hsa-miR-4276
    SwitchGear 3'UTR luciferase reporter plasmidCSTF1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CSTF1_HUMAN, Q05048: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS1358884
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with CSTF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSTF1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    Processing of Capped Intronless Pre-mRNA0.52
    Cleavage of Growing Transcript in the Termination Region0.80
    Processing of Intronless Pre-mRNAs0.00
    mRNA 3-end processing0.80
    3Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    4Gene Expression
    Gene Expression0.40
    5Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36


    Find genes that share SuperPaths with CSTF1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CSTF1
        Epithelial Tight Junctions

    2 BioSystems Pathways for CSTF1
        mRNA processing
    BARD1 signaling events


    4 Reactome Pathways for CSTF1
        mRNA Splicing - Major Pathway
    mRNA 3'-end processing
    Processing of Intronless Pre-mRNAs
    Cleavage of Growing Transcript in the Termination Region


    1 Kegg Pathway  (Kegg details for CSTF1):
        mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSTF1
    Interactions:

        GeneGlobe Interaction Network for CSTF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSTF1 (Q050481, 3 ENSP000002171094) via UniProtKB, MINT, STRING, and/or I2D (see all 111)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BARD1Q997281, 3, ENSP000002609474EBI-1789619,EBI-473181 I2D: score=4 STRING: ENSP00000260947
    TOLLIPQ9H0E21, 3, ENSP000003147334EBI-1789619,EBI-74615 I2D: score=1 STRING: ENSP00000314733
    BRCA1P383983, ENSP000003502834I2D: score=2 STRING: ENSP00000350283
    CSTF3Q129963, ENSP000003157914I2D: score=2 STRING: ENSP00000315791
    POLR2AP249283, ENSP000003149494I2D: score=2 STRING: ENSP00000314949
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006378mRNA polyadenylation TAS1358884
    GO:0006379mRNA cleavage TAS1358884

    Find genes that share ontologies with CSTF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CSTF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CSTF1 gene (3 alternative transcripts): 
    NM_001033521.1  NM_001033522.1  NM_001324.2  

    Unigene Cluster for CSTF1:

    Cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
    Hs.172865  [show with all ESTs]
    Unigene Representative Sequence: NM_001324
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498689 ENST00000415828 ENST00000217109(uc002xxl.1 uc002xxm.1)
    ENST00000428552 ENST00000452950 ENST00000493039(uc002xxn.1) ENST00000490539

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    hsa-miR-4303 hsa-miR-3200-5p hsa-miR-361-5p hsa-miR-499-3p hsa-miR-548b-3p hsa-miR-1257 hsa-miR-3692 hsa-miR-4276
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    Additional mRNA sequence: 

    AK293182.1 AK307144.1 AK312774.1 BC001011.2 BC007425.2 BT007138.1 L02547.1 

    17 DOTS entries:

    DT.446926  DT.100819283  DT.101979949  DT.95207765  DT.100819285  DT.100819287  DT.100819289  DT.101961447 
    DT.92443079  DT.95207755  DT.100819290  DT.120827407  DT.120827464  DT.91952259  DT.92443086  DT.95207767 
    DT.86853258 

    Selected AceView cDNA sequences (see all 266):

    AA620555 AA075587 BU753997 BG741462 BF724914 CR616080 CR592720 AA370886 
    BM423749 BE883058 BU189971 BM453971 AL602913 BU077567 CR602493 BM510591 
    BP378987 CA489452 BQ613989 AL538423 BM787470 CB305946 BI870514 BE786387 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CSTF1 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ·
    SP1:                                                  -     -     -                       -     -                                                               
    SP2:                                                  -     -     -                       -     -                                                               
    SP3:                          -     -     -     -     -     -     -                       -     -                                                               
    SP4:                                                              -                             -                                                               
    SP5:                    -     -     -     -     -     -     -     -                       -     -                                                               

    ExUns: 9c · 9d ^ 10
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for CSTF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSTF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTCTGAG
    CSTF1 Expression
    About this image

    CSTF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSTF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.172865
        Custom PCR Arrays for CSTF1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSTF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSTF1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cstf11 , 5 cleavage stimulation factor, 3' pre-RNA, subunit 11, 5 87.01(n)1
    99.54(a)1
      2 (94.84 cM)5
    673371  NM_024199.21  NP_077161.11 
     1723706815 
    chicken
    (Gallus gallus)
    Aves CSTF11 cleavage stimulation factor, 3' pre-RNA, subunit 1, more 80.74(n)
    98.14(a)
      419331  XM_004947233.1  XP_004947290.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSTF16
    cleavage stimulation factor, 3' pre-RNA, subunit 1...
    97(a)
    1 ↔ 1
    GL343217.1(2047399-2065773)
    African clawed frog
    (Xenopus laevis)
    Amphibia cstf1-prov2 cleavage stimulation factor, 3' pre-RNA, subunit 1 77.92(n)    BC043798.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc22d102 Danio rerio cDNA clone MGC66207 IMAGE5915050, complete more 78.57(n)    BC054661.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CstF-501 , 3 mRNA cleavage3
    CstF-501
    55(a)3
    57.8(n)1
    56.59(a)1
      100D13
    437341  NM_143626.21  NP_651883.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cpf-11 cpf-1 54.85(n)
    53.19(a)
      174378  NM_063421.5  NP_495822.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP46
    Splicing factor, component of the U4/U6-U5 snRNP c...
    15(a)
    1 → many
    XVI(892332-893729) YPR178W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G609401 AT5G60940 48.41(n)
    39.95(a)
      836215  NM_125487.2  NP_200902.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07549001 Os03g0754900 50.55(n)
    41.06(a)
      4334149  NM_001057844.1  NP_001051309.1 


    ENSEMBL Gene Tree for CSTF1 (if available)
    TreeFam Gene Tree for CSTF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSTF1 gene
    PRPF192  PRPF42  SPAG162  

    Find genes that share paralogs with CSTF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSTF1 (see all 289)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60697241,2
    C,F,A,H--54969377(+) TGGCTT/CGCGCC 3 -- int18Minor allele frequency- C:0.47MN WA NA 294
    rs1473335431,2
    --54969441(+) GTTTCA/GAGACC 3 -- int10--------
    rs1839032991,2
    --54969599(+) GATCGA/CGCCAC 3 -- int10--------
    rs2013668351,2
    --54969648(+) AAAAA-/GAAAAA 3 -- int10--------
    rs1881992941,2
    --54969711(+) TGTAGC/GCTTTT 3 -- int10--------
    rs1410070901,2
    C--54969732(+) CAAACA/TTACAC 3 -- int10--------
    rs1448923691,2
    --54969822(+) ATTTAC/TAGTTT 3 -- int10--------
    rs1161741541,2
    F--54969846(+) ACTGAA/CGGAAA 3 -- int11Minor allele frequency- C:0.01WA 118
    rs1815936531,2
    --54969883(+) GCACAA/GTCCTT 3 -- int10--------
    rs114785281,2
    C--54969903(+) TACTG-/TTTTTT 3 -- int1 trp32Minor allele frequency- T:0.00NA CSA 4

    HapMap Linkage Disequilibrium report for CSTF1 (54967427 - 54979582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CSTF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834013CNV Gain17160897
    nsv525425CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSTF1
    DNA2.0 Custom Variant and Variant Library Synthesis for CSTF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600369    OMIM disorders: --


    Find genes that share disorders with CSTF1           About GenesLikeMe

    Genetic Association Database (GAD): CSTF1
    Human Genome Epidemiology (HuGE) Navigator: CSTF1 (6 documents)

    Export disorders for CSTF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSTF1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with CSTF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human polyadenylation factor is a G protein beta-subunit homologue. (PubMed id 1358884)1, 2, 3 Takagaki Y. and Manley J.L. (J. Biol. Chem. 1992)
    2. Complex protein interactions within the human polyadenylation machinery identify a novel component. (PubMed id 10669729)1, 2, 9 Takagaki Y. and Manley J.L. (Mol. Cell. Biol. 2000)
    3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    6. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    7. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    8. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1477 HGNC: 2483 AceView: CSTF1 Ensembl:ENSG00000101138 euGenes: HUgn1477
    ECgene: CSTF1 Kegg: 1477 H-InvDB: CSTF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CSTF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSTF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSTF1 gene:
    Search GeneIP for patents involving CSTF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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