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Aliases for CSTF1 Gene

Aliases for CSTF1 Gene

  • Cleavage Stimulation Factor Subunit 1 2 3 5
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 1, 50kD 2 3
  • Cleavage Stimulation Factor 50 KDa Subunit 3 4
  • CF-1 50 KDa Subunit 3 4
  • CSTF 50 KDa Subunit 3 4
  • CstF-50 3 4
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 1, 50kDa 3
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 1 2
  • CstFp50 3

External Ids for CSTF1 Gene

Previous GeneCards Identifiers for CSTF1 Gene

  • GC20P054696
  • GC20P055605
  • GC20P055653
  • GC20P054401
  • GC20P054967
  • GC20P051752

Summaries for CSTF1 Gene

Entrez Gene Summary for CSTF1 Gene

  • This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSTF1 Gene

CSTF1 (Cleavage Stimulation Factor Subunit 1) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and RNA Polymerase II Transcription Termination. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for CSTF1 Gene

  • One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.

Gene Wiki entry for CSTF1 Gene

Additional gene information for CSTF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSTF1 Gene

Genomics for CSTF1 Gene

GeneHancer (GH) Regulatory Elements for CSTF1 Gene

Promoters and enhancers for CSTF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I056390 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 574.3 +0.1 63 3.8 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CSTF1 AURKA ENSG00000280387 GCNT7 CASS4
GH20I056629 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 27.2 +240.9 240911 9.4 HDGF PKNOX1 CLOCK NEUROD1 SIN3A ZBTB7B BRCA1 ELK1 ZNF207 ZNF143 TFAP2C CSTF1 ENSG00000280387 RNU6-1146P RAE1 FAM209A PTMAP6
GH20I056408 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.1 +24.7 24743 17 HNRNPUL1 PKNOX1 SMAD1 FOXA2 ARNT ZFP64 YBX1 YY1 POLR2B ZNF766 CASS4 RTF2 RPL39P CSTF1 ENSG00000280387 FAM210B GCNT7 FAM209B
GH20I056358 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 -31.0 -30999 6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 SP3 FAM210B AURKA CSTF1 GC20P056367
GH20I057038 Enhancer 0.8 ENCODE 24.5 +646.6 646629 0.2 HDGF PKNOX1 NFIB ZNF133 NEUROD1 BMI1 ZBTB7B TCF12 ZNF366 ZNF207 CSTF1 FAM209A ENSG00000280387 GCNT7 RAE1 LOC105372683 ENSG00000231078
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CSTF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CSTF1 gene promoter:

Genomic Locations for CSTF1 Gene

Genomic Locations for CSTF1 Gene
chr20:56,392,371-56,406,369
(GRCh38/hg38)
Size:
13,999 bases
Orientation:
Plus strand
chr20:54,967,427-54,979,582
(GRCh37/hg19)

Genomic View for CSTF1 Gene

Genes around CSTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSTF1 Gene

Proteins for CSTF1 Gene

  • Protein details for CSTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05048-CSTF1_HUMAN
    Recommended name:
    Cleavage stimulation factor subunit 1
    Protein Accession:
    Q05048
    Secondary Accessions:
    • Q5QPD8

    Protein attributes for CSTF1 Gene

    Size:
    431 amino acids
    Molecular mass:
    48358 Da
    Quaternary structure:
    • Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts directly with CSTF3. Interacts with BARD1.
    SequenceCaution:
    • Sequence=CAC12718.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CSTF1 Gene

Post-translational modifications for CSTF1 Gene

No data available for DME Specific Peptides for CSTF1 Gene

Domains & Families for CSTF1 Gene

Gene Families for CSTF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q05048

UniProtKB/Swiss-Prot:

CSTF1_HUMAN :
  • The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with CSTF3.
Domain:
  • The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with CSTF3.
  • N-terminus mediates homodimerization.
genes like me logo Genes that share domains with CSTF1: view

Function for CSTF1 Gene

Molecular function for CSTF1 Gene

GENATLAS Biochemistry:
cleavage stimulation factor,subunit 1,component of the 3 pre-RNA polyadenylation, homolog to the G protein beta-subunit
UniProtKB/Swiss-Prot Function:
One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.

Phenotypes From GWAS Catalog for CSTF1 Gene

Gene Ontology (GO) - Molecular Function for CSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22658674
GO:0005515 protein binding IPI 10477523
genes like me logo Genes that share ontologies with CSTF1: view
genes like me logo Genes that share phenotypes with CSTF1: view

Animal Model Products

miRNA for CSTF1 Gene

miRTarBase miRNAs that target CSTF1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSTF1 Gene

Localization for CSTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSTF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSTF1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CSTF1: view

Pathways & Interactions for CSTF1 Gene

genes like me logo Genes that share pathways with CSTF1: view

Pathways by source for CSTF1 Gene

Gene Ontology (GO) - Biological Process for CSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing IEA --
GO:0031124 mRNA 3-end processing TAS --
genes like me logo Genes that share ontologies with CSTF1: view

No data available for SIGNOR curated interactions for CSTF1 Gene

Drugs & Compounds for CSTF1 Gene

No Compound Related Data Available

Transcripts for CSTF1 Gene

Unigene Clusters for CSTF1 Gene

Cleavage stimulation factor, 3 pre-RNA, subunit 1, 50kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSTF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - -
SP9: - - - - - -
SP10: - - - - - - - - - -
SP11: - - - -
SP12: - -

ExUns: 9c · 9d ^ 10
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CSTF1 Gene

GeneLoc Exon Structure for
CSTF1
ECgene alternative splicing isoforms for
CSTF1

Expression for CSTF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSTF1 Gene

Protein differential expression in normal tissues from HIPED for CSTF1 Gene

This gene is overexpressed in Breast (34.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSTF1 Gene



Protein tissue co-expression partners for CSTF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CSTF1 Gene:

CSTF1

SOURCE GeneReport for Unigene cluster for CSTF1 Gene:

Hs.172865

Evidence on tissue expression from TISSUES for CSTF1 Gene

  • Muscle(4.2)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with CSTF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSTF1 Gene

Orthologs for CSTF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSTF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSTF1 33 34
  • 99.3 (n)
oppossum
(Monodelphis domestica)
Mammalia CSTF1 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSTF1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSTF1 33 34
  • 91.57 (n)
cow
(Bos Taurus)
Mammalia CSTF1 33 34
  • 89.64 (n)
rat
(Rattus norvegicus)
Mammalia Cstf1 33
  • 87.24 (n)
mouse
(Mus musculus)
Mammalia Cstf1 33 16 34
  • 87.01 (n)
chicken
(Gallus gallus)
Aves CSTF1 33 34
  • 80.74 (n)
lizard
(Anolis carolinensis)
Reptilia CSTF1 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cstf1 33
  • 76.57 (n)
Str.6242 33
African clawed frog
(Xenopus laevis)
Amphibia cstf1-prov 33
zebrafish
(Danio rerio)
Actinopterygii cstf1 33 34
  • 73.64 (n)
wufc22d10 33
fruit fly
(Drosophila melanogaster)
Insecta CstF-50 35 33 34
  • 57.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002776 33
  • 56.39 (n)
worm
(Caenorhabditis elegans)
Secernentea cpf-1 33 34
  • 54.85 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP4 34
  • 15 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60940 33
  • 48.41 (n)
rice
(Oryza sativa)
Liliopsida Os03g0754900 33
  • 50.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5452 34
  • 60 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14049 33
Species where no ortholog for CSTF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSTF1 Gene

ENSEMBL:
Gene Tree for CSTF1 (if available)
TreeFam:
Gene Tree for CSTF1 (if available)

Paralogs for CSTF1 Gene

No data available for Paralogs for CSTF1 Gene

Variants for CSTF1 Gene

Sequence variations from dbSNP and Humsavar for CSTF1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000195438 -- 56,400,646(+) T/C intron_variant
rs1000209810 -- 56,393,513(+) A/G intron_variant
rs1000407747 -- 56,396,810(+) G/A intron_variant
rs1000638371 -- 56,391,902(+) C/T upstream_transcript_variant
rs1000827368 -- 56,401,743(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CSTF1 Gene

Variant ID Type Subtype PubMed ID
nsv525425 CNV gain 19592680
nsv834013 CNV gain 17160897

Variation tolerance for CSTF1 Gene

Residual Variation Intolerance Score: 11.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSTF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSTF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSTF1 Gene

Disorders for CSTF1 Gene

Additional Disease Information for CSTF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CSTF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSTF1 Gene

Publications for CSTF1 Gene

  1. Complex protein interactions within the human polyadenylation machinery identify a novel component. (PMID: 10669729) Takagaki Y … Manley JL (Molecular and cellular biology 2000) 3 4 22 58
  2. A human polyadenylation factor is a G protein beta-subunit homologue. (PMID: 1358884) Takagaki Y … Manley JL (The Journal of biological chemistry 1992) 2 3 4 58
  3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  4. Nuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damage. (PMID: 20379136) Cevher MA … Kleiman FE (The EMBO journal 2010) 3 22 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for CSTF1 Gene

Sources for CSTF1 Gene

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