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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSTA Gene

protein-coding   GIFtS: 64
GCID: GC03P122044

cystatin A (stefin A)


(Previous symbols: STF1, STFA)
 Explore 41 diseases affiliated with
CSTA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CSTA    

Aliases
for CSTA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cystatin A (Stefin A)1 2     Cystatin AS2
STF11 2 3 5     Cystatin-A1
STFA1 2 3 5     Cystatin-AS3
AREI2     Stefin-A3

External Ids:    HGNC: 24811   Entrez Gene: 14752   Ensembl: ENSG000001215527   OMIM: 1846005   UniProtKB: P010403   

Export aliases for CSTA gene to outside databases

Previous GC identifers: GC03P118765 GC03P121992 GC03P123325 GC03P123364 GC03P123526 GC03P119417


Summaries
for CSTA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CSTA:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are
active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There
are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and
kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with
papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in
keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and
diagnostic tools for cancer. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CYTA_HUMAN, P01040
Function: This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell
adhesion in the lower levels of the epidermis

Gene Wiki entry for CSTA (Cystatin A)


Genomic Views
for CSTA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSTA gene promoter:
         HOXA9   GR   AML1a   Tal-1beta   Evi-1   GATA-1   E47   IRF-2   GR-alpha   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CSTA promoter sequence
   Search SABiosciences Chromatin IP Primers for CSTA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSTA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21

CSTA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSTA gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P122044:  view genomic region     (about GC identifiers)

Start:
 122,044,011 bp from pter      End:
 122,060,819 bp from pter
Size:
 16,809 bases      Orientation:
 plus strand

Proteins
for CSTA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CYTA_HUMAN, P01040 (See protein sequence)
Recommended Name: Cystatin-A  
Size: 98 amino acids; 11006 Da
Subcellular location: Cytoplasm
6/12 PDB 3D structures from and Proteopedia for CSTA (see all 12):
1CYU (3D)        1CYV (3D)        1DVC (3D)        1DVD (3D)        1GD3 (3D)        1GD4 (3D)    

Explore the universe of human proteins at neXtProt for CSTA: NX_P01040

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P01040

    • CSTA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005204.1  
    ENSEMBL proteins: 
     ENSP00000264474   ENSP00000418891  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CSTA (Cystatin A)
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    Novus Biologicals CSTA Proteins
    Novus Biologicals CSTA Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CSTA
    Uscn Proteins for CSTA

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001533cornified envelope IDA10908733
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--


    CSTA for ontologies           About GeneDecksing



    CSTA Antibody Products: 
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    Uscn ELISAs and CLIAs for CSTA

    Protein Domains /
    Families
    for CSTA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CSTA for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001713 Prot_inh_stefinA
     IPR018073 Prot_inh_cystat_CS
     IPR000010 Prot_inh_cystat

    Graphical View of Domain Structure for InterPro Entry P01040

    ProtoNet protein and cluster: P01040

    2 Blocks protein families:
    IPB000010 Cysteine protease inhibitor
    IPB001713 Stefin A signature


    UniProtKB/Swiss-Prot: CYTA_HUMAN, P01040
    Similarity: Belongs to the cystatin family


    Function
    for CSTA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CYTA_HUMAN, P01040
    Function: This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell
    adhesion in the lower levels of the epidermis

         Genatlas biochemistry entry for CSTA:
    cystatin A,cysteine proteinase inhibitor,type 2 family

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSTA
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CSTA:
    hsa-miR-575 hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmid: CSTA 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSTA (see all 4)
    OriGene shRNA RFP: CSTA
    OriGene siRNA: CSTA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSTA

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSTA 

    Cell Line
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    Search LifeMap BioReagents cell lines for CSTA

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI6203523
    GO:0004869cysteine-type endopeptidase inhibitor activity IDA6203523
    GO:0005198structural molecule activity IDA10908733
    GO:0030674protein binding, bridging IDA10908733


    CSTA for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CSTA:
     Increased HPV18 LCR reporter a 


    Pathways & Interactions
    for CSTA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSTA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/31 Interacting proteins for CSTA (P010402, 3 ENSP000002644744) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTNP212462, 3MINT-63344 I2D: score=4 
    CTSBP078582, 3, ENSP000003420704MINT-7990451 I2D: score=4 STRING: ENSP00000342070
    LORP234903, ENSP000003577314I2D: score=1 STRING: ENSP00000357731
    PI3P199573, ENSP000002439244I2D: score=1 STRING: ENSP00000243924
    CTSL1P077113, ENSP000003453444I2D: score=3 STRING: ENSP00000345344
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010466negative regulation of peptidase activity IDA6203523
    GO:0016337cell-cell adhesion IMP--
    GO:0018149peptide cross-linking IDA10908733
    GO:0030216keratinocyte differentiation IDA10908733


    CSTA for ontologies           About GeneDecksing



    Drugs & Compounds
    for CSTA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CSTA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CSTA
    10/15 Novoseek chemical compound relationships for CSTA gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 81.2 91 9182808 (3), 10215884 (3), 17208452 (3), 2097084 (2) (see all 57)
    actinidin 66.4 1 7575465 (1)
    kininogen 65.1 10 1801728 (2), 7872798 (1), 2237263 (1), 2107324 (1) (see all 7)
    thioflavin t 37.4 1 16342276 (1)
    allergens 31.4 12 18087159 (4), 19933866 (3), 15990791 (1)
    leupeptin 30.6 1 1316092 (1)
    trifluoroethanol 28.7 7 10398367 (5)
    matrigel 21.2 1 16361563 (1)
    12-o-tetradecanoylphorbol 13-acetate 21.1 2 12682854 (1), 11451947 (1)
    tyrosine 0 1 1859820 (1)

    Search CenterWatch for drugs/clinical trials and news about CSTA / CYTA 

    Transcripts
    for CSTA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CSTA gene: 
    NM_005213.3  

    Unigene Cluster for CSTA:

    Cystatin A (stefin A)
    Hs.518198  [show with all ESTs]
    Unigene Representative Sequence: CD520285
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264474(uc003eex.3) ENST00000479204

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSTA
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CSTA:
    hsa-miR-575 hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmid: CSTA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSTA (see all 4)
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSTA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSTA

    Additional cDNA sequence: 

    AK291308.1 BC010379.1 CR456914.1 X05978.1 

    6 DOTS entries:

    DT.412417  DT.91989276  DT.91829137  DT.92015891  DT.95309312  DT.92391909 

    24/135 AceView cDNA sequences (see all 135):

    AA022874 W77844 AW014844 BM969426 AA583844 BX397459 BX477597 BM955512 
    AW275102 BX330266 AI341447 BG695875 X05978 BX099127 BM955513 CR456914 
    CB126035 AW079037 BC010379 N46874 BF437687 AV716538 AI912935 AI093212 

    GeneLoc Exon Structure


    Expression
    for CSTA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSTA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATCCTTGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CSTA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CSTA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSTA

    SOURCE GeneReport for Unigene cluster: Hs.518198

    UniProtKB/Swiss-Prot: CYTA_HUMAN, P01040
    Tissue specificity: Expressed in the skin throughout the epidermis

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    In Situ
    Assay Products:     
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    Orthologs
    for CSTA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CSTA gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Gm54835
    Csta1    		 predicted gene 54835
    cystatin A1    		 74.23(n)1
    63.92(a)1    		   16 (25.43 cM)5
    2092941  NM_001033239.31  NP_001028411.11 
     361842125 
    chicken
    (Gallus gallus)    		 Aves CSTA1 cystatin A (stefin A) 60.48(n)
    55.67(a)    		   418268  XM_416493.3  XP_416493.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-161h7.66
    zgc:1531296
    (see all 3)    		 zgc:153129
    (see all 3)    		 45(a)
    44(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 24(21525203-21526864)
    5(4447662-4456545)


    ENSEMBL Gene Tree for CSTA (if available)
    TreeFam Gene Tree for CSTA (if available) 

    Paralogs
    for CSTA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSTA gene
    CSTB2  
    1 SIMAP similar gene for CSTA using alignment to 3 protein entries:     CYTA_HUMAN (see all proteins):
    CSTB

    CSTA for paralogs           About GeneDecksing



    Genomic Variants
    for CSTA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/364 NCBI SNPs in CSTA are shown (see all 364)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1928548131,2
    		--122042101(+) AGTGGA/CCTATG 1 -- us2k10--------
    rs1451754771,2
    		--122042127(+) TCTTCA/TGATGA 1 -- us2k10--------
    rs1846547871,2
    		--122042262(+) CTTAGA/CTCCAA 1 -- us2k10--------
    rs1466549711,2
    		--122042417(+) AACCTA/GTATAG 1 -- us2k10--------
    rs1402273791,2
    		--122042425(+) TAGATA/GAATAT 1 -- us2k10--------
    rs622691381,2
    		--122042451(+) TGTGCA/GTGTGT 1 -- us2k10--------
    rs113018271,2
    		C--122042467(+) TTTTT-/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.00NA 2
    rs28776031,2
    		C,--122042492(+) ttgagG/Acacag 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs23321821,2
    		C,--122042500(+) CAGTAT/ATGCTC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs23321831,2
    		C,A,H,--122042510(+) CTGTCG/ACCAGG 1 -- us2k14Minor allele frequency- A:0.00NA 10

    HapMap Linkage Disequilibrium report for CSTA (122044011 - 122060819 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CSTA
         1 CNV: 7357
    Human Gene Mutation Database (HGMD): CSTA

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSTA
    DNA2.0 Custom Variant and Variant Library Synthesis for CSTA

    Disorders / Diseases
    for CSTA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CSTA for disorders           About GeneDecksing

    OMIM gene information: 184600    OMIM disorders: --

    UniProtKB/Swiss-Prot: CYTA_HUMAN, P01040
  • Defects in CSTA are the cause of ichthyosis exfoliative autosomal recessive ichthyosis bullosa of Siemens-like
    • (AREI) [MIM:607936]. A form of congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of
    Siemens and annular epidermolytic ichthyosis. AREI presents shortly after birth as dry, scaly skin over most of the
    body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture
    and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the
    epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments
    in the basal keratinocytes

    20/41 diseases for CSTA (see all 41):    About MalaCards
    ichthyosis bullosa of siemens    exfoliative ichthyosis    inverted papilloma    otitis media
    squamous cell carcinoma    ichthyosis    squamous cell carcinoma of the head and neck    esophageal squamous cell carcinoma
    atopic dermatitis    herpes simplex    pituitary adenoma    skin disease
    papilloma    liver cirrhosis    dermatitis    prostate adenocarcinoma
    carcinoma    ovarian carcinoma    alzheimer's disease    laryngitis

    10/24 Novoseek disease relationships for CSTA gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 41 13 16361563 (3), 12392065 (2), 1326833 (2), 8824783 (1) (see all 7)
    lung tumor 39.6 3 9330706 (2), 8014475 (1)
    meningioma 35.1 3 19747051 (2), 12160137 (1)
    benign prostatic hyperplasia 32.9 6 10652560 (1), 11536307 (1), 17595755 (1), 12539227 (1)
    prostatic intraepithelial neoplasia 29.1 2 17595755 (1), 12539227 (1)
    tumors 22.6 31 17595755 (3), 16361563 (3), 9065652 (2), 8014475 (2) (see all 17)
    psoriasis 22.2 3 15175029 (2), 15187321 (1)
    metastasis 19.3 17 17985332 (5), 16361563 (4), 12392065 (1), 8014475 (1) (see all 7)
    dermatitis atopic 19.2 6 18087159 (2), 17441792 (2), 8844122 (1)
    prostatic adenocarcinoma 17.1 1 12539227 (1)

    Genetic Association Database (GAD): CSTA
    Human Genome Epidemiology (HuGE) Navigator: CSTA (5 documents)

    Export disorders for CSTA gene to outside databases

    Publications
    for CSTA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSTA gene, integrated from 9 sources (see all 205):
    (articles sorted by number of sources associating them with CSTA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Solution structure of a human cystatin A variant, cystatin A2-98 M65L, by NMR spectroscopy. A possible role of the interactions between the N- and C-termini to maintain the inhibitory active form of cystatin A. (PubMed id 7578072)1, 2, 9 Tate S.... Kainosho M. (1995)
    2. The three-dimensional solution structure of human stefin A. (PubMed id 7869384)1, 2, 9 Martin J.R.... Waltho J.P. (1995)
    3. Genomic structure of human cystatin A. (PubMed id 9522124)1, 2, 9 Yamazaki M.... Ogawa H. (1997)
    4. Association analysis of cystatin A and zinc finger protein 148, two genes located at the psoriasis susceptibility locus PSORS5. (PubMed id 15175029)1, 4, 9 Samuelsson L....Wahlstrom J. (2004)
    5. Structure and transcriptional regulation of the human cystatin A gene. The 12-o-tetradecanoylphorbol-13-acetate (tpa) responsive element-2 site (-272 to -278) on cystatin a gene is critical for tpa- dependent regulation. (PubMed id 9651321)1, 2, 9 Takahashi H....Iizuka H. (1998)
    6. Molecular cloning, occurrence, and expression of a novel partially secreted protein 'psoriasin' that is highly up-regulated in psoriatic skin. (PubMed id 1940442)1, 2, 9 Madsen P.... Celis J.E. (1991)
    7. Mutations in CSTA, encoding Cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion. (PubMed id 21944047)1, 2 Blaydon D.C.... Kelsell D.P. (2011)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)
    10. Comparative studies on the primary structure of human cystatin as from epidermis, liver, spleen, and leukocytes. (PubMed id 2768224)1, 2 Takeda A.... Samejima T. (1989)

    External Searches for CSTA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing CSTA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1475 HGNC: 2481 AceView: CSTA Ensembl:ENSG00000121552 euGenes: HUgn1475
    ECgene: CSTA H-InvDB: CSTA

    Other Databases showing CSTA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CSTA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSTA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSTA Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CSTA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CSTA gene:
    Search GeneIP for patents involving CSTA

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