CST9L Gene
protein-coding GIFtS: 46
GCID: GC20M023545
|
|
cystatin 9-like(Previous name: cystatin 9 (mouse)-like )
| |
Aliases
for CST9L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cystatin 9-Like1 2 | | CTES7B1 2 | | BA218C14.11 | | Cystatin 9 (Mouse)-Like1 | | Cystatin-9-Like1 | | Testatin1 |
Export aliases for CST9L gene to outside databasesPrevious GC identifers: GC20M023533 GC20M023493 GC20M023540 GC20M023506 |
Summaries
for CST9L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CST9L:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members areactive cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. Thereare three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and thekininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of humanfluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes andpseudogenes. This gene is located in the cystatin locus and encodes a protein similar to mouse cystatin 9. Based onits testis-specific expression, it is likely to have a role in tissue reorganization during early testis development.(provided by RefSeq, Jul 2008)
Gene Wiki entry for CST9L
|
Genomic Views
for CST9L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CST9L gene promoter:
SRY ISGF-3 POU2F1 POU2F1a Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CST9L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST9L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p11.21 Ensembl cytogenetic band: 20p11.21 HGNC cytogenetic band: 20p11.21CST9L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M023545: view genomic region
(about GC identifiers)
Start:
|
23,545,369 bp from pter |
End:
|
23,549,386 bp from pter |
Size:
|
4,018 bases |
Orientation:
|
minus strand |
|
Proteins
for CST9L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CST9L_HUMAN, Q9H4G1 (See
protein sequence)Recommended Name: Cystatin-9-like precursor Size: 147 amino acids; 17276 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B2R5A1Explore the universe of human proteins at neXtProt for CST9L: NX_Q9H4G1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H4G1
CST9L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_542177.1
ENSEMBL proteins: ENSP00000366178
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CST9L for ontologies About GeneDecksing
CST9L Antibody Products:
Assay Products for CST9L: |
Protein
Domains /
Families
for CST9L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CST9L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H4G1ProtoNet protein and cluster: Q9H4G1 2 Blocks protein families: IPB000010 Cysteine protease inhibitor IPB003243 Proteinase inhibitor I25A and I25B
UniProtKB/Swiss-Prot: CST9L_HUMAN, Q9H4G1Similarity: Belongs to the cystatin family |
Function
for CST9L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CST9L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CST9L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for CST9L | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CST9L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST9L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST9L |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004869 | cysteine-type endopeptidase inhibitor activity |
IEA | -- |
CST9L for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CST9L:
Animal Models:
Mouse knock-outs for CST9L: Cst9tm1Aw Cst9tm1Nnkj
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Cst9):
CST9L for phenotypes About GeneDecksing
|
Pathways & Interactions
for CST9L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CST9L
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for CST9L (ENSP000003661784) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CST9L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CST9L for compounds About GeneDecksing
 Browse Tocris compounds for CST9L
1 Novoseek chemical compound relationship for CST9L gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cysteine |
58.4 |
3 |
11756564 (1), 12586767 (1), 12644294 (1) |
Search CenterWatch for drugs/clinical trials and news about CST9L
|
Transcripts
for CST9L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CST9L gene: NM_080610.2 Unigene Cluster for CST9L: Cystatin 9-like Hs.121554 [show with all ESTs]Unigene Representative Sequence: NM_0806101 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000376979(uc002wtk.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CST9L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CST9L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CST9L | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CST9L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST9L |
Additional cDNA sequence: AK312112.1 AY358615.1 BC029656.1 1 DOTS entry: DT.409828 24/32 AceView cDNA sequences (see all 32): AY358615 BX380551 AW572915 AA608859 BC029656 NM_080610 AI631708 AI638675 BE500968 AA496078 AW024125 AA812885 AA911102 AA973942 AA758532 BI825261 AF494536 BX402568 BX104050 AW104268 AA968716 BP369653 BE041425 AA934362
GeneLoc Exon Structure
|
Expression
for CST9L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CST9L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTGTAGAT
About this image
See CST9L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CST9L
SOURCE GeneReport for Unigene cluster: Hs.121554
SABiosciences Custom PCR Arrays for CST9L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CST9L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CST9L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CST9L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST9L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST9L |
Orthologs
for CST9L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for CST9L (if available)
TreeFam Gene Tree for CST9L (if available) |
Paralogs
for CST9L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CST9L gene
- CST92 CST9LP12
5 SIMAP similar genes for CST9L using alignment to 1 protein entry: CST9L_HUMAN:CST9LP1 CST9 CSTL1 CST2 CST11
CST9L for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CST9L
PGOHUM00000247611
|
Genomic Variants
for CST9L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CST9L (23545369 - 23549386 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CST9L
1 Inversion: 59770 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CST9L |
|
Disorders
/ Diseases
for CST9L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CST9L for disorders About GeneDecksing
1  disease for CST9L: About MalaCardsepididymitis
Human Genome Epidemiology (HuGE) Navigator: CST9L (1 document)
Export disorders for CST9L gene to outside databases
|
Publications
for CST9L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CST9L gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with CST9L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evolution and human tissue expression of the Cres/Tes tatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cys tatins. (PubMed id 20565543)1, 3 Frygelius J....TAPhAPnen V. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Isolation of the human testatin gene and analysis in patients with abnormal gonadal development. (PubMed id 11756564)1, 9 Eriksson A....Nordqvist K. (2002)
- A new subgroup of the family 2 cystatins. (PubMed id 12644294)1, 9 Cornwall G.A. and Hsia N. (2003)
- A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)1 Hwang S.J....Fox C.S. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for CST9L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CST9L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CST9L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CST9L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CST9L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CST9L gene:
Search GeneIP for patents involving CST9L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CST9L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CST9L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CST9L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CST9L | | | OriGene Protein Over-expression Lysate for CST9L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CST9L | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CST9L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CST9L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CST9L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CST9L | | OriGene Custom Protein Services for CST9L | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CST9L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CST9L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST9L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CST9L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST9L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CST9L |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CST9L |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CST9L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST9L |
|  |  |  | | | | Search ThermoFisher Antibodies for CST9L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST9L |
|
|
|
|
