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Aliases for CST9L Gene

Aliases for CST9L Gene

  • Cystatin 9-Like 2 3 5
  • Testatin 3 4
  • CTES7B 3 4
  • Testicular Tissue Protein Li 45 3
  • Cystatin 9 (Mouse)-Like 2
  • BA218C14.1 3

External Ids for CST9L Gene

Previous GeneCards Identifiers for CST9L Gene

  • GC20M023533
  • GC20M023493
  • GC20M023540
  • GC20M023506

Summaries for CST9L Gene

Entrez Gene Summary for CST9L Gene

  • The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to mouse cystatin 9. Based on its testis-specific expression, it is likely to have a role in tissue reorganization during early testis development. [provided by RefSeq, Jul 2008]

GeneCards Summary for CST9L Gene

CST9L (Cystatin 9-Like) is a Protein Coding gene. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST9.

Gene Wiki entry for CST9L Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CST9L Gene

Genomics for CST9L Gene

Regulatory Elements for CST9L Gene

Genomic Location for CST9L Gene

Chromosome:
20
Start:
23,564,732 bp from pter
End:
23,568,749 bp from pter
Size:
4,018 bases
Orientation:
Minus strand

Genomic View for CST9L Gene

Genes around CST9L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CST9L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CST9L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CST9L Gene

Proteins for CST9L Gene

  • Protein details for CST9L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4G1-CST9L_HUMAN
    Recommended name:
    Cystatin-9-like
    Protein Accession:
    Q9H4G1
    Secondary Accessions:
    • B2R5A1

    Protein attributes for CST9L Gene

    Size:
    147 amino acids
    Molecular mass:
    17276 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Lacks critical consensus sites important for cysteine protease inhibition.

neXtProt entry for CST9L Gene

Proteomics data for CST9L Gene at MOPED

Post-translational modifications for CST9L Gene

  • Glycosylation at Asn 117 and Asn 139
  • Modification sites at PhosphoSitePlus

Other Protein References for CST9L Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CST9L

No data available for DME Specific Peptides for CST9L Gene

Domains & Families for CST9L Gene

Gene Families for CST9L Gene

Suggested Antigen Peptide Sequences for CST9L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4G1

UniProtKB/Swiss-Prot:

CST9L_HUMAN :
  • Belongs to the cystatin family.
Family:
  • Belongs to the cystatin family.
genes like me logo Genes that share domains with CST9L: view

Function for CST9L Gene

Gene Ontology (GO) - Molecular Function for CST9L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CST9L: view
genes like me logo Genes that share phenotypes with CST9L: view

Animal Models for CST9L Gene

MGI Knock Outs for CST9L:

Animal Model Products

CRISPR Products

miRNA for CST9L Gene

miRTarBase miRNAs that target CST9L

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CST9L Gene

Localization for CST9L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CST9L Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CST9L Gene COMPARTMENTS Subcellular localization image for CST9L gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for CST9L Gene

Pathways & Interactions for CST9L Gene

SuperPathways for CST9L Gene

No Data Available

Gene Ontology (GO) - Biological Process for CST9L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CST9L Gene

Drugs & Compounds for CST9L Gene

(1) Drugs for CST9L Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CST9L: view

Transcripts for CST9L Gene

mRNA/cDNA for CST9L Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CST9L Gene

Cystatin 9-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CST9L Gene

No ASD Table

Relevant External Links for CST9L Gene

GeneLoc Exon Structure for
CST9L
ECgene alternative splicing isoforms for
CST9L

Expression for CST9L Gene

mRNA expression in normal human tissues for CST9L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CST9L Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for CST9L Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CST9L Gene



SOURCE GeneReport for Unigene cluster for CST9L Gene Hs.121554

mRNA Expression by UniProt/SwissProt for CST9L Gene

Q9H4G1-CST9L_HUMAN
Tissue specificity: Specifically espressed in testis.
genes like me logo Genes that share expression patterns with CST9L: view

Protein tissue co-expression partners for CST9L Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CST9L Gene

This gene was present in the common ancestor of mammals.

Orthologs for CST9L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC740314 35
  • 98.64 (n)
  • 96.58 (a)
CST9L 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 41 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
LOC505033 35
  • 68.16 (n)
  • 52.99 (a)
dog
(Canis familiaris)
Mammalia CST9 35
  • 67.73 (n)
  • 55.2 (a)
CST9L 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 9230104L09Rik 36
  • 41 (a)
ManyToMany
Cst9 16
Cst9 35
  • 64.42 (n)
  • 56.73 (a)
rat
(Rattus norvegicus)
Mammalia Cst9l 35
  • 65.06 (n)
  • 54.81 (a)
Species with no ortholog for CST9L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CST9L Gene

ENSEMBL:
Gene Tree for CST9L (if available)
TreeFam:
Gene Tree for CST9L (if available)

Paralogs for CST9L Gene

Paralogs for CST9L Gene

(5) SIMAP similar genes for CST9L Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CST9L Gene

genes like me logo Genes that share paralogs with CST9L: view

Variants for CST9L Gene

Sequence variations from dbSNP and Humsavar for CST9L Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2295564 - 23,566,002(+) GGAAA(A/G/T)GGCAG reference, missense
rs1467502 -- 23,568,694(+) CTAGG(C/G)CAGCA utr-variant-5-prime
rs2247337 -- 23,567,764(+) ACTGG(C/T)GGGGG intron-variant
rs1966183 -- 23,570,094(+) cctcc(A/G)cctcc upstream-variant-2KB
rs1973958 -- 23,570,095(+) ctccg(C/T)ctccc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CST9L Gene

Variant ID Type Subtype PubMed ID
dgv4559n71 CNV Gain 21882294
nsv912820 CNV Gain+Loss 21882294
nsv470544 CNV Gain 18288195
nsv458949 CNV Gain 19166990
esv7185 OTHER Inversion 19470904

Variation tolerance for CST9L Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 50.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CST9L Gene

HapMap Linkage Disequilibrium report
CST9L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CST9L Gene

Disorders for CST9L Gene

Relevant External Links for CST9L

Genetic Association Database (GAD)
CST9L
Human Genome Epidemiology (HuGE) Navigator
CST9L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CST9L

No disorders were found for CST9L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CST9L Gene

Publications for CST9L Gene

  1. Evolution and human tissue expression of the Cres/Testatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cystatins. (PMID: 20565543) Frygelius J. … TAPhAPnen V. (Evol. Dev. 2010) 2 3 4 67
  2. A new subgroup of the family 2 cystatins. (PMID: 12644294) Cornwall G.A. … Hsia N. (Mol. Cell. Endocrinol. 2003) 3 23
  3. Isolation of the human testatin gene and analysis in patients with abnormal gonadal development. (PMID: 11756564) Eriksson A. … Nordqvist K. (Mol. Hum. Reprod. 2002) 3 23
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for CST9L Gene

Sources for CST9L Gene

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