CST9 Gene
protein-coding GIFtS: 43
GCID: GC20M023583
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cystatin 9 (testatin)
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Aliases
for CST9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cystatin 9 (Testatin)1 2 | | CLM1 2 3 | | CTES7A1 2 | | Cystatin-Like Molecule2 3 | | Cystatin-91 |
Export aliases for CST9 gene to outside databasesPrevious GC identifers: GC20M023579 GC20M023532 GC20M023534 GC20M023535 GC20M023536 GC20M023537 GC20M023538 GC20M023539 GC20M023541 |
Summaries
for CST9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CST9:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members areactive cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. Thereare three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and thekininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of humanfluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 containsthe majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes asecreted protein that may play a role in hematopoietic differentiation or inflammation. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CST9_HUMAN, Q5W186Function: May play a role in hematopoietic differentiation or inflammation
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Genomic Views
for CST9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CST9 gene promoter:
STAT5B Bach1 ISGF-3 HTF Bach2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) Nkx2-5 POU3F2 FOXC1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CST9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p11.21 Ensembl cytogenetic band: 20p11.21 HGNC cytogenetic band: 20p11.21CST9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M023583: view genomic region
(about GC identifiers)
Start:
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23,583,047 bp from pter |
End:
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23,586,610 bp from pter |
Size:
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3,564 bases |
Orientation:
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minus strand |
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Proteins
for CST9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CST9_HUMAN, Q5W186 (See
protein sequence)Recommended Name: Cystatin-9 precursor Size: 159 amino acids; 18135 Da
Subcellular location: Secreted. Note=May be targeted through the Golgi via the secretory pathway
Secondary accessions: B2RP76 Q8TD53Explore the universe of human proteins at neXtProt for CST9: NX_Q5W186
CST9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001008693.2
ENSEMBL proteins: ENSP00000366170
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CST9 for ontologies About GeneDecksing
CST9 Antibody Products:
Assay Products for CST9: |
Protein
Domains /
Families
for CST9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CST9 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5W186ProtoNet protein and cluster: Q5W186 UniProtKB/Swiss-Prot: CST9_HUMAN, Q5W186Similarity: Belongs to the cystatin family |
Function
for CST9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CST9_HUMAN, Q5W186Function: May play a role in hematopoietic differentiation or inflammationInduction: Up-regulated by bacterial lipopolysaccharides (LPS), in some cancer cells such as promyelocytic leukemiacells (HL-60) or myelomonocytic leukemia cells (U-937)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CST9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST9 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004869 | cysteine-type endopeptidase inhibitor activity |
IEA | -- |
CST9 for ontologies About GeneDecksing
|
Pathways & Interactions
for CST9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CST9
|
Drugs & Compounds
for CST9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CST9
Search CenterWatch for drugs/clinical trials and news about CST9
|
Transcripts
for CST9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CST9 gene: NM_001008693.2 Unigene Cluster for CST9: Cystatin 9 (testatin) Hs.698020 [show with all ESTs]Unigene Representative Sequence: NM_0010086931 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000376971(uc002wtl.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CST9
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CST9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CST9 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CST9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST9 |
Additional cDNA sequence: AF494536.1 BC137302.1 BC137303.1 1 DOTS entry: DT.91682323 24/32 AceView cDNA sequences (see all 32): BX380551 AW572915 BC029656 AA496078 AI638675 AA608859 AI631708 BE500968 NM_080610 AY358615 AW024125 BX104050 AA911102 AA758532 BI825261 AA973942 AA812885 AA968716 BX402568 AF494536 AW104268 AA513329 AA934362 BF056783
GeneLoc Exon Structure
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Expression
for CST9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CST9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCCCCCTC
About this image
See CST9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CST9
SOURCE GeneReport for Unigene cluster: Hs.698020
UniProtKB/Swiss-Prot: CST9_HUMAN, Q5W186Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle and pancreas. Not expressed in brain.Barely expressed in tumor cell lines except for breast adenocarcinoma MCF-7 cells and U-251MG cells
SABiosciences Custom PCR Arrays for CST9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CST9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CST9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CST9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST9 |
Orthologs
for CST9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for CST9 (if available)
TreeFam Gene Tree for CST9 (if available) |
Paralogs
for CST9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CST9 gene
- CST9LP12 CST9L2
2 SIMAP similar genes for CST9 using alignment to 1 protein entry: CST9_HUMAN:CST9LP1 CST9L
CST9 for paralogs About GeneDecksing
|
Genomic Variants
for CST9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CST9 (23583047 - 23586610 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CST9: --
Human Gene Mutation Database (HGMD): CST9
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CST9 |
|
Disorders
/ Diseases
for CST9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CST9 for disorders About GeneDecksing
5  diseases for CST9: About MalaCardsmyelomonocytic leukemia kidney disease breast adenocarcinoma adenocarcinoma
leukemia
Human Genome Epidemiology (HuGE) Navigator: CST9 (1 document)
Export disorders for CST9 gene to outside databases
|
Publications
for CST9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CST9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CST9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of a novel cystatin-like molecule, CLM, from human bone marrow stromal cells. (PubMed id 12535658)1, 2, 9 Sun H.... Cao X. (2003)
- Evolution and human tissue expression of the Cres/Tes tatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cys tatins. (PubMed id 20565543)1, 3 Frygelius J....TAPhAPnen V. (2010)
- New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1 KAPttgen A....Fox C.S. (2010)
- A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)1 Hwang S.J....Fox C.S. (2007)
- A genomic analysis of rat proteases and protease inhibitors. (PubMed id 15060002)1 Puente X.S. and Lopez-Otin C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)2 Deloukas P....Rogers J. (2001)
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External Searches for CST9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CST9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CST9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CST9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CST9 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CST9 gene:
Search GeneIP for patents involving CST9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CST9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | | | Recombinant Protein for CST9 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST9 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST9 |
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