Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CST8 Gene

protein-coding   GIFtS: 48
GCID: GC20P023471

cystatin 8 (cystatin-related epididymal specific)

 Explore 7 diseases affiliated with
CST8 via our new
 Human Malady Compendium 
Biological research products
for CST8
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cystatin 8 (Cystatin-Related Epididymal Specific)1 2
CRES1 2 3
CTES51 2
Cystatin-Related Epididymal Spermatogenic Protein2 3
Cystatin-81
Cystatin-Related Epididymal-Specific2

External Ids:    HGNC: 24801   Entrez Gene: 100472   Ensembl: ENSG000001258157   OMIM: 6086835   UniProtKB: O606763   

Export aliases for CST8 gene to outside databases

Previous GC identifers: GC20P023459 GC20P023466 GC20P023419


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CST8:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are
active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There
are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the
kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human
fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and
pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The protein
exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction.
Alternative splicing identified in mouse is suggested in human based on EST evidence but the full-length nature of
putative variants has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CST8_HUMAN, O60676
Function: Performs a specialized role during sperm development and maturation

Gene Wiki entry for CST8


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CST8 gene promoter:
         Sox5   C/EBPbeta   AP-1   ATF-2   C/EBPalpha   PPAR-gamma1   Ik-2   GATA-6   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCST8 promoter sequence
   Search SABiosciences Chromatin IP Primers for CST8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.21   Ensembl cytogenetic band:  20p11.21   HGNC cytogenetic band: 20p11.21

CST8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CST8 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P023471:  view genomic region     (about GC identifiers)

Start:
23,471,738 bp from pter      End:
23,476,660 bp from pter
Size:
4,923 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CST8_HUMAN, O60676 (See protein sequence)
Recommended Name: Cystatin-8 precursor  
Size: 142 amino acids; 16275 Da
Subcellular location: Secreted
Secondary accessions: Q2M2X6

Explore the universe of human proteins at neXtProt for CST8: NX_O60676

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60676

  • CST8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005483.1  
    ENSEMBL proteins: 
     ENSP00000399144   ENSP00000246012  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CST8
    OriGene Custom Protein Services for CST8 
    GenScript Custom Purified and Recombinant Proteins Services for CST8
    Novus Biologicals CST8 Proteins
    Novus Biologicals CST8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CST8

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IEA--
    GO:0009986cell surface IEA--


    CST8 for ontologies           About GeneDecksing



    CST8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CST8 
    GenScript Custom Superior Antibodies Services for CST8
    Novus Biologicals CST8 Antibodies
    Search for Antibodies for CST8 at Abcam  
    Uscn Antibodies for CST8
    ThermoFisher Antibody for CST8

    Assay Products for CST8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CST8
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CST8


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CST8 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000010 Prot_inh_cystat
     IPR027214 Cystatin

    Graphical View of Domain Structure for InterPro Entry O60676

    ProtoNet protein and cluster: O60676

    2 Blocks protein families:
    IPB000010 Cysteine protease inhibitor
    IPB003243 Proteinase inhibitor I25A and I25B


    UniProtKB/Swiss-Prot: CST8_HUMAN, O60676
    Similarity: Belongs to the cystatin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CST8_HUMAN, O60676
    Function: Performs a specialized role during sperm development and maturation

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CST8
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CST8
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CST8 (see all 7)
    OriGene shRNA RFP: CST8
    OriGene siRNA: CST8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CST8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CST8

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CST8 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CST8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CST8 (NM_005492)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CST8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CST8
    Search LifeMap BioReagents cell lines for CST8

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST8

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004869cysteine-type endopeptidase inhibitor activity IEA--


    CST8 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CST8:
     Decreased viability of wild-ty 

    Animal Models:
         Mouse knock-out Cst8tm1Cnw for CST8
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cst8):
     no phenotypic analysis 

    CST8 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CST8

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CST8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CST8
    1 Novoseek chemical compound relationship for CST8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 55.7 4 12586767 (1), 12644294 (1), 17589787 (1)

    Search CenterWatch for drugs/clinical trials and news about CST8 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CST8 gene: 
    NM_005492.2  

    Unigene Cluster for CST8:

    Cystatin 8 (cystatin-related epididymal specific)
    Hs.121602  [show with all ESTs]
    Unigene Representative Sequence: AF059244
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449810 ENST00000246012(uc002wth.1)

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CST8
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CST8
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CST8 (see all 7)
    OriGene shRNA RFP: CST8
    OriGene siRNA: CST8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CST8
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CST8 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CST8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CST8 (NM_005492)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CST8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST8 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CST8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CST8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CST8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST8

    Additional cDNA sequence: 

    AF059244.1 BC069496.1 BC069536.1 BC105113.1 BC105119.1 

    2 DOTS entries:

    DT.310273  DT.92023909 

    11 AceView cDNA sequences:

    NM_005492 AA843468 BC069536 BX096109 AF059244 BC069496 AA918572 AW665128 
    AA759355 AA436982 AW665453 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CST8    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
    SP1:              -                           
    SP2:                                          


    ECgene alternative splicing isoforms for CST8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CST8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CST8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FollicleGranulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CST8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CST8

    SOURCE GeneReport for Unigene cluster: Hs.121602

    UniProtKB/Swiss-Prot: CST8_HUMAN, O60676
    Tissue specificity: Proximal caput region of the epididymis. Lower expression in the testis. Within the testis it is
    localized to the elongating spermatids, whereas within the epididymis it is exclusively synthesized by the proximal
    caput epithelium

        SABiosciences Custom PCR Arrays for CST8
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CST8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CST8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CST8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CST8 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii cst36
    zgc:1630306
    zgc:163030
    30(a)
    29(a)
    many ↔ many
    many ↔ many
    13(33900031-33908388)
    13(33894411-33896169)


    ENSEMBL Gene Tree for CST8 (if available)
    TreeFam Gene Tree for CST8 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CST8 gene
    CST22  CSTL12  CST72  CST12  CST32  CST62  CST42  CST52  
    CST112  
    9 SIMAP similar genes for CST8 using alignment to 2 protein entries:     CST8_HUMAN (see all proteins):
    CST11    CST1    CST2    CST4    CST5    CST3
    CSTL1    CST7    CST6

    CST8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/219 NCBI SNPs in CST8 are shown (see all 219    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919837931,2
    --23469806(+) GAAGTA/GCAGAT 1 -- us2k10--------
    rs1393943061,2
    --23469851(+) GGAACC/TCCTGG 1 -- us2k10--------
    rs1845829081,2
    --23469857(+) CCTGGA/GGAACT 1 -- us2k10--------
    rs61379841,2
    C,--23469864(+) AACTTT/AAAAAA 1 -- us2k1 tfbs33Minor allele frequency- A:0.15NA EA 242
    rs750024831,2
    C,F,--23469910(+) ATTTTA/GTCAGT 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1441706901,2
    --23469960(+) TAACAC/TGCAGC 1 -- us2k10--------
    rs750394181,2
    F,--23470003(+) AGTGAC/TGAACA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs760736881,2
    --23470015(+) TTTGGC/TAATAA 1 -- us2k10--------
    rs1487044881,2
    --23470026(+) ATAATA/GAATTT 1 -- us2k10--------
    rs1894509781,2
    --23470040(+) TTTGCA/GTAAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CST8 (23471738 - 23476660 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CST8: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CST8
    DNA2.0 Custom Variant and Variant Library Synthesis for CST8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CST8 for disorders           About GeneDecksing

    OMIM gene information: 608683    OMIM disorders: --

    7 diseases for CST8:    About MalaCards
    epididymitis    cerebral hemorrhage    choriocarcinoma    t-cell leukemia
    cerebritis    leukemia    melanoma

    Human Genome Epidemiology (HuGE) Navigator: CST8 (1 document)

    Export disorders for CST8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CST8 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with CST8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transient appearance of CRES protein during spermatogenesis and caput epididymal sperm maturation. (PubMed id 7619504)2, 3, 9 Cornwall G.A. and Hann S.R. (1995)
    2. Evolution and human tissue expression of the Cres/Tes tatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cys tatins. (PubMed id 20565543)1, 3 Frygelius J....TAPhAPnen V. (2010)
    3. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Identification and characterization of cystatin-related epididymal spermatogenic protein in human spermatozoa: localization in the equatorial segment. (PubMed id 12193387)1, 9 Wassler M....Cornwall G.A. (2002)
    7. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1 Chapuis J....Lambert J.C. (2009)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Structure, alternative splicing and chromosomal localization of the cystatin-related epididymal spermatogenic gene. (PubMed id 10229662)1 Cornwall G.A....Sutton H.G. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10047 HGNC: 2480 AceView: CST8 Ensembl:ENSG00000125815 euGenes: HUgn10047
    ECgene: CST8 H-InvDB: CST8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CST8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CST8 gene:
    Search GeneIP for patents involving CST8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CST8  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CST8   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CST8  
     OriGene Protein Over-expression Lysate for CST8   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CST8   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CST8   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CST8  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CST8   OriGene Custom Protein Services for CST8  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CST8
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CST8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CST8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CST8
     GenScript Custom Purified and Recombinant Proteins Services for CST8 GenScript cDNA clones with any tag delivered in your preferred vector for CST8
     GenScript Custom Assay Services for CST8 GenScript Custom Superior Antibodies Services for CST8
     GenScript Custom overexpressing Cell Line Services for CST8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CST8 promoter
     Search Chromatin IP Primers for CST8
     RT2 qPCR Primer Assay in human, mouse, rat CST8
     GNC Network for CST8
     SABiosciences Custom PCR Arrays for CST8
     Search Tocris compounds for CST8
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CST8 antibodies
     CST8 proteins
     CST8 lysates
     Search for Antibodies for CST8 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CST8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CST8 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CST8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST8
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CST8
     SwitchGear Promoter luciferase reporter plasmids for CST8
     ThermoFisher Antibody for CST8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST8
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CST8 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4