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Aliases for CST7 Gene

Aliases for CST7 Gene

  • Cystatin F (Leukocystatin) 2 3
  • Cystatin-Like Metastasis-Associated Protein 3 4
  • Leukocystatin 3 4
  • Cystatin-7 3 4
  • CMAP 3 4
  • Cystatin-F 3

External Ids for CST7 Gene

Previous GeneCards Identifiers for CST7 Gene

  • GC20P024917
  • GC20P024877
  • GC20P024924

Summaries for CST7 Gene

Entrez Gene Summary for CST7 Gene

  • The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for CST7 Gene

CST7 (Cystatin F (Leukocystatin)) is a Protein Coding gene. GO annotations related to this gene include endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST6.

UniProtKB/Swiss-Prot for CST7 Gene

  • Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system

Gene Wiki entry for CST7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CST7 Gene

Genomics for CST7 Gene

Regulatory Elements for CST7 Gene

Genomic Location for CST7 Gene

Start:
24,949,230 bp from pter
End:
24,959,928 bp from pter
Size:
10,699 bases
Orientation:
Plus strand

Genomic View for CST7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CST7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CST7 Gene

Proteins for CST7 Gene

  • Protein details for CST7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76096-CYTF_HUMAN
    Recommended name:
    Cystatin-F
    Protein Accession:
    O76096
    Secondary Accessions:
    • Q6FH95
    • Q7Z4J8
    • Q9UED4

    Protein attributes for CST7 Gene

    Size:
    145 amino acids
    Molecular mass:
    16454 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=AAH15507.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAP88827.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA34941.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB11886.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB75498.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CST7 Gene

neXtProt entry for CST7 Gene

Proteomics data for CST7 Gene at MOPED

Post-translational modifications for CST7 Gene

  • Glycosylation at Asn62 and Asn115
  • Modification sites at PhosphoSitePlus

Other Protein References for CST7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CST7 Gene

Domains for CST7 Gene

Suggested Antigen Peptide Sequences for CST7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76096

UniProtKB/Swiss-Prot:

CYTF_HUMAN :
  • O76096
Family:
  • Belongs to the cystatin family.
genes like me logo Genes that share domains with CST7: view

No data available for Gene Families for CST7 Gene

Function for CST7 Gene

Molecular function for CST7 Gene

UniProtKB/Swiss-Prot Function: Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system

Gene Ontology (GO) - Molecular Function for CST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity TAS 9632704
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 18256700
genes like me logo Genes that share ontologies with CST7: view

Phenotypes for CST7 Gene

MGI mutant phenotypes for CST7:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CST7: view

Animal Models for CST7 Gene

MGI Knock Outs for CST7:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CST7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CST7 Gene

Localization for CST7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CST7 Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CST7 Gene COMPARTMENTS Subcellular localization image for CST7 gene
Compartment Confidence
extracellular 5
lysosome 2
cytosol 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CST7: view

Pathways for CST7 Gene

SuperPathways for CST7 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 9632704
GO:0010951 negative regulation of endopeptidase activity TAS 9632704
genes like me logo Genes that share ontologies with CST7: view

No data available for Pathways by source for CST7 Gene

Compounds for CST7 Gene

(2) Novoseek inferred chemical compound relationships for CST7 Gene

Compound -log(P) Hits PubMed IDs
mannose 6-phosphate 64.5 3
cysteine 54.6 7
genes like me logo Genes that share compounds with CST7: view

Transcripts for CST7 Gene

mRNA/cDNA for CST7 Gene

(60) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CST7 Gene

Cystatin F (leukocystatin):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CST7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CST7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
SP1: -
SP2:
SP3:

Relevant External Links for CST7 Gene

GeneLoc Exon Structure for
CST7
ECgene alternative splicing isoforms for
CST7

Expression for CST7 Gene

mRNA expression in normal human tissues for CST7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CST7 Gene

This gene is overexpressed in Whole Blood (48.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CST7 Gene

SOURCE GeneReport for Unigene cluster for CST7 Gene Hs.143212

mRNA Expression by UniProt/SwissProt for CST7 Gene

O76096-CYTF_HUMAN
Tissue specificity: Primarily expressed in peripheral blood cells and spleen
genes like me logo Genes that share expressions with CST7: view

In Situ Assay Products

Orthologs for CST7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CST7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CST7 35
  • 97.47 (n)
  • 96.55 (a)
CST7 36
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CST7 35
  • 74.48 (n)
  • 71.72 (a)
CST7 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CST7 35
  • 81.59 (n)
  • 75.24 (a)
CST7 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cst7 35
  • 78.33 (n)
  • 72.14 (a)
Cst7 16
Cst7 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CST7 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cst7 35
  • 77.07 (n)
  • 71.63 (a)
chicken
(Gallus gallus)
Aves CST7 35
  • 57.38 (n)
  • 50.71 (a)
CST7 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cst7 35
  • 56.11 (n)
  • 55 (a)
zebrafish
(Danio rerio)
Actinopterygii CST7 36
  • 32 (a)
OneToOne
Species with no ortholog for CST7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CST7 Gene

ENSEMBL:
Gene Tree for CST7 (if available)
TreeFam:
Gene Tree for CST7 (if available)

Paralogs for CST7 Gene

Paralogs for CST7 Gene

Selected SIMAP similar genes for CST7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CST7: view

Variants for CST7 Gene

Sequence variations from dbSNP and Humsavar for CST7 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1465 -- 24,959,789(-) GGGTC(A/G)TGAGG utr-variant-3-prime
rs127131 -- 24,953,195(+) CCAGT(A/C)GATGC intron-variant
rs227649 -- 24,948,462(+) gttta(C/T)tgcag upstream-variant-2KB
rs227650 -- 24,949,171(-) GGCTG(C/T)CTGCG upstream-variant-2KB
rs227651 -- 24,949,198(-) TGGGA(C/T)GGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CST7 Gene

Variant ID Type Subtype PubMed ID
nsv522873 CNV Gain 19592680
nsv510783 CNV Loss 20534489
nsv524921 CNV Gain 19592680
esv1703823 CNV Insertion 17803354

Relevant External Links for CST7 Gene

HapMap Linkage Disequilibrium report
CST7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CST7 Gene

Disorders for CST7 Gene

(3) Novoseek inferred disease relationships for CST7 Gene

Disease -log(P) Hits PubMed IDs
metastasis 11.4 7
tumors 0 6
cancer 0 6
genes like me logo Genes that share disorders with CST7: view

No data available for UniProtKB/Swiss-Prot for CST7 Gene

Publications for CST7 Gene

  1. Leukocystatin, a new class II cystatin expressed selectively by hematopoietic cells. (PMID: 9632704) Halfon S. … Zurawski G. (J. Biol. Chem. 1998) 2 3 4 23
  2. Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor. (PMID: 9733783) Ni J. … Abrahamson M. (J. Biol. Chem. 1998) 2 3 4 23
  3. Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3). (PMID: 10945474) Morita M. … Nishimura S. (Genomics 2000) 3 4 23
  4. Regulated expression and intracellular localization of cystatin F in human U937 cells. (PMID: 12423348) Nathanson C.M. … Abrahamson M. (Eur. J. Biochem. 2002) 3 4 23
  5. Structural basis of reduction-dependent activation of human cystatin F. (PMID: 16601115) Schuettelkopf A.W. … van Aalten D.M.F. (J. Biol. Chem. 2006) 3 4 23

Products for CST7 Gene

Sources for CST7 Gene

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