Aliases for CST6 Gene
External Ids for CST6 Gene
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]
GeneCards Summary for CST6 Gene
CST6 (Cystatin E/M) is a Protein Coding gene. Diseases associated with CST6 include breast cancer. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST7.
UniProtKB/Swiss-Prot for CST6 Gene
Shows moderate inhibition of cathepsin B but is not active against cathepsin C