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Aliases for CST6 Gene

Aliases for CST6 Gene

  • Cystatin E/M 2 3
  • Cystatin-6 3 4
  • Cystatin-E 3 4
  • Cysteine Proteinase Inhibitor 3
  • Cystatin M/E 3
  • Cystatin 6 3
  • Cystatin M 3
  • Cystatin-M 3

External Ids for CST6 Gene

Previous GeneCards Identifiers for CST6 Gene

  • GC11P068313
  • GC11P067460
  • GC11P065554
  • GC11P065536
  • GC11P065779
  • GC11P062105

Summaries for CST6 Gene

Entrez Gene Summary for CST6 Gene

  • The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]

GeneCards Summary for CST6 Gene

CST6 (Cystatin E/M) is a Protein Coding gene. Diseases associated with CST6 include breast cancer. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST7.

UniProtKB/Swiss-Prot for CST6 Gene

  • Shows moderate inhibition of cathepsin B but is not active against cathepsin C

Gene Wiki entry for CST6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CST6 Gene

Genomics for CST6 Gene

Regulatory Elements for CST6 Gene

Genomic Location for CST6 Gene

66,011,841 bp from pter
66,013,505 bp from pter
1,665 bases
Plus strand

Genomic View for CST6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CST6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CST6 Gene

Proteins for CST6 Gene

  • Protein details for CST6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q540N7

    Protein attributes for CST6 Gene

    149 amino acids
    Molecular mass:
    16511 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CST6 Gene

neXtProt entry for CST6 Gene

Proteomics data for CST6 Gene at MOPED

Post-translational modifications for CST6 Gene

  • Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor
  • Glycosylation at Asn137
  • Modification sites at PhosphoSitePlus

Other Protein References for CST6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CST6 Gene

Domains for CST6 Gene

Suggested Antigen Peptide Sequences for CST6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q15828
  • Belongs to the cystatin family.
genes like me logo Genes that share domains with CST6: view

No data available for Gene Families for CST6 Gene

Function for CST6 Gene

Molecular function for CST6 Gene

GENATLAS Biochemistry: cystatin M,member of type 2 cystatin gene family,found at high levels in saliva,tears,seminal plasma,type 2 family
UniProtKB/Swiss-Prot Function: Shows moderate inhibition of cathepsin B but is not active against cathepsin C

Gene Ontology (GO) - Molecular Function for CST6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with CST6: view
genes like me logo Genes that share phenotypes with CST6: view

miRNA for CST6 Gene

miRTarBase miRNAs that target CST6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CST6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CST6 Gene

Localization for CST6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CST6 Gene


Subcellular locations from

Jensen Localization Image for CST6 Gene COMPARTMENTS Subcellular localization image for CST6 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CST6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CST6: view

Pathways for CST6 Gene

SuperPathways for CST6 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CST6 Gene

Gene Ontology (GO) - Biological Process for CST6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development IEA --
GO:0009653 anatomical structure morphogenesis TAS 9099741
GO:0010951 negative regulation of endopeptidase activity TAS 8995380
genes like me logo Genes that share ontologies with CST6: view

No data available for Pathways by source for CST6 Gene

Compounds for CST6 Gene

(4) Novoseek inferred chemical compound relationships for CST6 Gene

Compound -log(P) Hits PubMed IDs
cysteine 69.8 22
5-aza-2deoxycytidine 62.4 3
matrigel 57.6 5
kininogen 54.5 1
genes like me logo Genes that share compounds with CST6: view

Transcripts for CST6 Gene

mRNA/cDNA for CST6 Gene

(72) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CST6 Gene

Cystatin E/M:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CST6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CST6 Gene

No ASD Table

Relevant External Links for CST6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CST6 Gene

mRNA expression in normal human tissues for CST6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CST6 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (30.0) and Skin - Sun Exposed (Lower leg) (16.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CST6 Gene

SOURCE GeneReport for Unigene cluster for CST6 Gene Hs.139389

mRNA Expression by UniProt/SwissProt for CST6 Gene

Tissue specificity: Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity.
genes like me logo Genes that share expressions with CST6: view

In Situ Assay Products

Orthologs for CST6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CST6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CST6 35
  • 99.78 (n)
  • 99.33 (a)
CST6 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 81 (a)
CST6 35
  • 86.09 (n)
  • 77.95 (a)
CST6 36
  • 69 (a)
(Canis familiaris)
Mammalia CST6 35
  • 82.8 (n)
  • 75.4 (a)
CST6 36
  • 74 (a)
(Mus musculus)
Mammalia Cst6 35
  • 80.09 (n)
  • 69.13 (a)
Cst6 16
Cst6 36
  • 69 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
-- 36
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia CST6 36
  • 47 (a)
(Rattus norvegicus)
Mammalia Cst6 35
  • 79.19 (n)
  • 69.8 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
-- 36
  • 41 (a)
Species with no ortholog for CST6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CST6 Gene

Gene Tree for CST6 (if available)
Gene Tree for CST6 (if available)

Paralogs for CST6 Gene

Paralogs for CST6 Gene

Selected SIMAP similar genes for CST6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CST6: view

Variants for CST6 Gene

Sequence variations from dbSNP and Humsavar for CST6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs603598 -- 66,010,523(-) gagtt(C/G)gagac upstream-variant-2KB
rs615646 -- 66,010,073(-) ttcag(C/T)ggaat upstream-variant-2KB
rs632578 -- 66,013,724(+) GAGCC(A/C)CCACA downstream-variant-500B
rs632640 -- 66,013,771(+) GGTGG(C/G)GGCAG downstream-variant-500B
rs1051196 -- 66,013,456(+) CTTCA(C/G)GTCCG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CST6 Gene

Variant ID Type Subtype PubMed ID
nsv832191 CNV Loss 17160897
dgv1186n71 CNV Loss 21882294
nsv825952 CNV Gain 20364138

Relevant External Links for CST6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CST6 Gene

Disorders for CST6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CST6 Gene including...

Search for CST6 Gene in MalaCards »

(10) Novoseek inferred disease relationships for CST6 Gene

Disease -log(P) Hits PubMed IDs
harlequin ichthyosis 84.3 5
primary tumor 51.2 10
breast cancer metastatic 42.3 3
breast cancer 40.7 21
breast carcinoma 36.3 9
genes like me logo Genes that share disorders with CST6: view

No data available for UniProtKB/Swiss-Prot for CST6 Gene

Publications for CST6 Gene

  1. Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins. (PMID: 9099741) Ni J. … Gentz R. (J. Biol. Chem. 1997) 2 3 4 23
  2. The human cystatin M/E gene (CST6): exclusion candidate gene for harlequin ichthyosis. (PMID: 12839564) Zeeuwen P.L. … Schalkwijk J. (J. Invest. Dermatol. 2003) 3 4 23
  3. Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: a new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase. (PMID: 11348457) Zeeuwen P.L. … Schalkwijk J. (J. Invest. Dermatol. 2001) 3 4 23
  4. Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer. (PMID: 8995380) Sotiropoulou G. … Sager R. (J. Biol. Chem. 1997) 3 4 23
  5. Assignment of a novel cysteine proteinase inhibitor (CST6) to 11q13 by fluorescence in situ hybridization. (PMID: 9154125) Stenman G. … Sager R. (Cytogenet. Cell Genet. 1997) 2 3

Products for CST6 Gene

Sources for CST6 Gene

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