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Aliases for CST5 Gene

Aliases for CST5 Gene

  • Cystatin D 2 3 5
  • Cystatin-5 3 4
  • Cysteine-Proteinase Inhibitor 3
  • Cystatin 5 3

External Ids for CST5 Gene

Previous GeneCards Identifiers for CST5 Gene

  • GC20M023844
  • GC20M023804

Summaries for CST5 Gene

Entrez Gene Summary for CST5 Gene

  • The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. [provided by RefSeq, Jul 2008]

GeneCards Summary for CST5 Gene

CST5 (Cystatin D) is a Protein Coding gene. Among its related pathways are Endochondral Ossification and Salivary secretion. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST2.

UniProtKB/Swiss-Prot for CST5 Gene

  • Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.

Gene Wiki entry for CST5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CST5 Gene

Genomics for CST5 Gene

Regulatory Elements for CST5 Gene

Enhancers for CST5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CST5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CST5 Gene

23,875,935 bp from pter
23,879,750 bp from pter
3,816 bases
Minus strand

Genomic View for CST5 Gene

Genes around CST5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CST5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CST5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CST5 Gene

Proteins for CST5 Gene

  • Protein details for CST5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5JRF5
    • Q9UCA0

    Protein attributes for CST5 Gene

    142 amino acids
    Molecular mass:
    16080 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CST5 Gene

neXtProt entry for CST5 Gene

Proteomics data for CST5 Gene at MOPED

Post-translational modifications for CST5 Gene

No Post-translational modifications

Other Protein References for CST5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CST5 Gene

Domains & Families for CST5 Gene

Gene Families for CST5 Gene

Suggested Antigen Peptide Sequences for CST5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cystatin family.
  • Belongs to the cystatin family.
genes like me logo Genes that share domains with CST5: view

Function for CST5 Gene

Molecular function for CST5 Gene

GENATLAS Biochemistry:
cystatin D,cysteine proteinase inhibitor,found at high levels in salviva,tears,seminal plasma,type 2 family
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Temperature dependence: Thermostable. {ECO:0000269 PubMed:8083219};
UniProtKB/Swiss-Prot Function:
Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.

Gene Ontology (GO) - Molecular Function for CST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8083219
genes like me logo Genes that share ontologies with CST5: view
genes like me logo Genes that share phenotypes with CST5: view

Animal Models for CST5 Gene

MGI Knock Outs for CST5:

Animal Model Products

miRNA for CST5 Gene

miRTarBase miRNAs that target CST5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CST5 Gene

Localization for CST5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CST5 Gene


Subcellular locations from

Jensen Localization Image for CST5 Gene COMPARTMENTS Subcellular localization image for CST5 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for CST5 Gene

Pathways & Interactions for CST5 Gene

genes like me logo Genes that share pathways with CST5: view

Pathways by source for CST5 Gene

1 BioSystems pathway for CST5 Gene
1 KEGG pathway for CST5 Gene

Interacting Proteins for CST5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000307132 P28325-CYTD_HUMAN for CST5 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CST5 Gene


No data available for SIGNOR curated interactions for CST5 Gene

Drugs & Compounds for CST5 Gene

(1) Drugs for CST5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CST5: view

Transcripts for CST5 Gene

mRNA/cDNA for CST5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CST5 Gene

Cystatin D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CST5 Gene

No ASD Table

Relevant External Links for CST5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CST5 Gene

mRNA expression in normal human tissues for CST5 Gene

mRNA differential expression in normal tissues according to GTEx for CST5 Gene

This gene is overexpressed in Esophagus - Muscularis (x27.0), Adrenal Gland (x7.5), and Lung (x6.3).

Protein differential expression in normal tissues from HIPED for CST5 Gene

This gene is overexpressed in Skin (37.9) and Salivary gland (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CST5 Gene

SOURCE GeneReport for Unigene cluster for CST5 Gene Hs.121489

mRNA Expression by UniProt/SwissProt for CST5 Gene

Tissue specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in parotid gland but not in seminal vesicle, prostate, epididymis, testis, ovary, placenta, thyroid, gastric corpus, small intestine, liver, or gall bladder tissue.
genes like me logo Genes that share expression patterns with CST5: view

Protein tissue co-expression partners for CST5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CST5 Gene

Orthologs for CST5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CST5 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Cst10 35
  • 57.62 (n)
  • 42.64 (a)
Cst10 16
Cst10 36
  • 39 (a)
(Rattus norvegicus)
Mammalia Cst5 35
  • 59.42 (n)
  • 46.38 (a)
(Bos Taurus)
Mammalia CST3 36
  • 46 (a)
(Canis familiaris)
Mammalia -- 36
  • 46 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
(Gallus gallus)
Aves gga-mir-3526 36
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
(Danio rerio)
Actinopterygii cst3 36
  • 28 (a)
Species with no ortholog for CST5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CST5 Gene

Gene Tree for CST5 (if available)
Gene Tree for CST5 (if available)

Paralogs for CST5 Gene

Paralogs for CST5 Gene

(10) SIMAP similar genes for CST5 Gene using alignment to 1 proteins: Pseudogenes for CST5 Gene

genes like me logo Genes that share paralogs with CST5: view

Variants for CST5 Gene

Sequence variations from dbSNP and Humsavar for CST5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1799841 - 23,879,541(-) TGCAG(C/T)GTGCC reference, missense
rs2071442 -- 23,879,861(-) AGATA(C/G)AGACA upstream-variant-2KB
rs2071443 -- 23,879,116(-) GCCAC(A/G)AGGTT intron-variant
rs2071444 -- 23,877,697(-) AGTGA(C/T)TCAGT intron-variant
rs2071445 -- 23,877,345(-) GGATG(C/T)ATTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CST5 Gene

Variant ID Type Subtype PubMed ID
dgv698e201 CNV Deletion 23290073
nsv833944 CNV Gain 17160897

Variation tolerance for CST5 Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CST5 Gene

Disorders for CST5 Gene

Relevant External Links for CST5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CST5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CST5 Gene

Publications for CST5 Gene

  1. Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor. (PMID: 1939105) Freije J.P. … Lopez-Otin C. (J. Biol. Chem. 1991) 2 3 4 23 67
  2. Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. (PMID: 19662683) Alvarez-DA-az S. … MuA+oz A. (J. Clin. Invest. 2009) 3 23
  3. Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile. (PMID: 15728581) Alvarez-Fernandez M. … Su X.D. (J. Biol. Chem. 2005) 3 23
  4. Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases. (PMID: 8083219) Balbin M. … Abrahamson M. (J. Biol. Chem. 1994) 3 23
  5. Human cystatin D. cDNA cloning, characterization of the Escherichia coli expressed inhibitor, and identification of the native protein in saliva. (PMID: 8340398) Freije J.P. … Lopez-Otin C. (J. Biol. Chem. 1993) 3 23

Products for CST5 Gene

Sources for CST5 Gene