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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CST5 Gene

protein-coding GIFtS: 55
GCID: GC20M023851

cystatin D

Explore 8 diseases affiliated with
CST5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cystatin D¹ ²
Cystatin 5²
Cystatin-5³
Cystatin-D¹
Cysteine-Proteinase Inhibitor²
Cystatin-5³

External Ids:	HGNC: 2477¹	Entrez Gene: 1473²	Ensembl: ENSG00000170367⁷	OMIM: 123858⁵	UniProtKB: P28325³

Export aliases for CST5 gene to outside databases

Previous GC identifers: GC20M023844 GC20M023804

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CST5:

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are

active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There

are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the

kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human

fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and

pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded

protein may play a protective role against proteinases present in the oral cavity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CYTD_HUMAN, P28325

Function: Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral

cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B

Gene Wiki entry for CST5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CST5 gene promoter:
SREBP-1a Zic1 SREBP-1c MyoD Nkx2-5 Nkx5-1 TGIF SREBP-1b
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CST5 promoter sequence

Search SABiosciences Chromatin IP Primers for CST5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.21 Ensembl cytogenetic band: 20p11.21 HGNC cytogenetic band: 20p11.21

CST5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CST5 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M023851: view genomic region (about GC identifiers)

Start:	23,856,572 bp from pter	End:	23,860,387 bp from pter
Size:	3,816 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CYTD_HUMAN, P28325 (See protein sequence)

Recommended Name: Cystatin-D precursor

Size: 142 amino acids; 16080 Da

Subunit: Monomer

Subcellular location: Secreted

Mass spectrometry: Mass=13154.4675; Mass_error=0.0101; Method=Electrospray; Range=29-142; Note=Variant Arg-46;

Source=PubMed:20189825;

Mass spectrometry: Mass=13596.7015; Mass_error=0.0049; Method=Electrospray; Range=25-142; Note=Variant Arg-46;

Source=PubMed:20189825;

Caution: The truncated forms found may result from N-terminal proteolysis (PubMed:20189825)

2 PDB 3D structures from and Proteopedia for CST5:

1RN7 (3D)

1ROA (3D)

Secondary accessions: Q5JRF5 Q9UCA0

Explore the universe of human proteins at neXtProt for CST5: NX_P28325

CST5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001891.2

ENSEMBL proteins:

ENSP00000307132

Human Recombinant Protein Products:

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	Uscn Proteins for CST5

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IDA	8083219

CST5 for ontologies About GeneDecksing

CST5 Antibody Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CST5 for domains About GeneDecksing

3 InterPro domains/families:

IPR018073 Prot_inh_cystat_CS

IPR000010 Prot_inh_cystat

IPR027214 Cystatin

Graphical View of Domain Structure for InterPro Entry P28325

ProtoNet protein and cluster: P28325

2 Blocks protein families:

IPB000010 Cysteine protease inhibitor

IPB003243 Proteinase inhibitor I25A and I25B

UniProtKB/Swiss-Prot: CYTD_HUMAN, P28325

Similarity: Belongs to the cystatin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CYTD_HUMAN, P28325

Function: Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral

cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B

Biophysicochemical properties: Temperature dependence: Thermostable;

Genatlas biochemistry entry for CST5:

cystatin D,cysteine proteinase inhibitor,found at high levels in salviva,tears,seminal plasma,type 2 family

miRNA Products:		OriGene 3'-UTR Clone: CST5 Browse MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CST5
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST5

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004869	cysteine-type endopeptidase inhibitor activity	IDA	8083219
GO:0005515	protein binding	IPI	8083219

CST5 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CST5:

Decreased cilium length after

Animal Models:
Mouse knock-out Cst10^tm1Hkaw for CST5
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cst10):

homeostasis/metabolism

limbs/digits/tail

skeleton

CST5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Endochondral Ossification

Endochondral Ossification

1.00

Gastric acid secretion

Salivary secretion

0.35

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for CST5

Endochondral Ossification

1 Kegg Pathway (Kegg details for CST5):

Salivary secretion

CST5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CST5

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for CST5 (P28325³ ENSP00000307132⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTSS	P25774³, ENSP00000357981⁴	I2D: score=2 STRING: ENSP00000357981

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CST5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CST5
1 Novoseek chemical compound relationship for CST5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cysteine	65.7	16	8083219 (4), 9573825 (2), 1939105 (2), 8340398 (1) (see all 8)

Search CenterWatch for drugs/clinical trials and news about CST5 / CYTD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CST5 gene:

NM_001900.4

Unigene Cluster for CST5:

Cystatin D

Hs.121489 [show with all ESTs]

Unigene Representative Sequence: CB987021

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000304710(uc002wtr.1)

miRNA Products:		OriGene 3'-UTR Clone: CST5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CST5
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST5

Additional cDNA sequence:

BC062678.1 BC069514.1 X70377.1

1 DOTS entry:

DT.204835

13 AceView cDNA sequences:

NM_001900 BC062678 BC069514 X70377 BP333996 BP334744 BP334786 BP334002

BP334304 CB957678 CB987021 BP333854 CB985957

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CST5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCCTGCACC

About this image

CST5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CST5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CST5

SOURCE GeneReport for Unigene cluster: Hs.121489

UniProtKB/Swiss-Prot: CYTD_HUMAN, P28325

Tissue specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level).

Expressed in parotid gland but not in seminal vesicle, prostate, epididymis, testis, ovary, placenta, thyroid, gastric

corpus, small intestine, liver, or gall bladder tissue

SABiosciences Custom PCR Arrays for CST5

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CST5 gene from 3/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CYT_CHICK⁶	Cystatin	35(a)	1 → many	3(16498156-16500488)
lizard (Anolis carolinensis)	Reptilia	--	--	32(a)	1 → many	4(82204275-82217421)
zebrafish (Danio rerio)	Actinopterygii	zgc:163030⁶ cst3⁶	zgc:163030 cystatin C (amyloid angiopathy and cerebral hemorr...	28(a) 28(a)	many ↔ many many ↔ many	13(33894411-33896169) 13(33900031-33908388)

ENSEMBL Gene Tree for CST5 (if available)
TreeFam Gene Tree for CST5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CST5 gene

CST2² CSTL1² CST7² CST1² CST3² CST6² CST4² CST8²

CST11²

10 SIMAP similar genes for CST5 using alignment to 1 protein entry: CYTD_HUMAN:

CST2 CST4 CST1 CST3 CST9LP1 CST11

CST8 CST6 CSTL1 CST7

CST5 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CST5
PGOHUM00000247471

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145378412^1,2		--	23856120(+)	`CCCTGA/GGGCAC`	1	--	int¹		0	--	--	--	--
rs113912147^1,2		--	23856176(+)	`TCTTGC/TCCATC`	1	--	int¹		2		CSA WA	119
rs192623144^1,2		--	23856226(+)	`CACATA/TCACAC`	1	--	int¹		0	--	--	--	--
rs75018625^1,2	C	--	23856272(+)	`CTTGTG/TGAAAG`	1	--	int¹		0	--	--	--	--
rs78001899^1,2	C	--	23856273(+)	`TTGTGA/GAAAGA`	1	--	int¹		0	--	--	--	--
rs76968158^1,2	C	--	23856274(+)	`TGTGGA/TAAGAA`	1	--	int¹		0	--	--	--	--
rs149188932^1,2		--	23856292(+)	`TCGATC/TGCTAT`	1	--	int¹		0	--	--	--	--
rs6049201^1,2	F,H,	--	23856378(+)	`ATCCAC/TGGCCT`	1	--	int¹		6		NS EA CSA WA	540
rs201950445^1,2		--	23856508(+)	`GCTTC-/ATAAAGG`	1	--	int¹		0	--	--	--	--
rs117440485^1,2	F,	--	23856551(+)	`CCAAAC/TAGCCA`	1	--	int¹		1		EA	120

HapMap Linkage Disequilibrium report for CST5 (23856572 - 23860387 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CST5
1 CNV: 5129

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CST5

DNA2.0 Custom Variant and Variant Library Synthesis for CST5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CST5 for disorders           About GeneDecksing

OMIM gene information: 123858    OMIM disorders: --

8 diseases for CST5:    About MalaCards

herpes simplex cerebral hemorrhage rheumatoid arthritis cerebritis

colon cancer arthritis thyroiditis prostatitis

Human Genome Epidemiology (HuGE) Navigator: CST5 (1 document)

Export disorders for CST5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CST5 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with CST5)

Utopia: connect your pdf to the dynamic
world of online information

Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor. (PubMed id 1939105)^{1, 2, 3, 9} Freije J.P....Lopez-Otin C. (1991)
Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases. (PubMed id 8083219)^{1, 2, 9} Balbin M....Abrahamson M. (1994)
Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile. (PubMed id 15728581)^{1, 2, 9} Alvarez-Fernandez M.... Su X.D. (2005)
Human cystatin D. cDNA cloning, characterization of the Escherichia coli expressed inhibitor, and identification of the native protein in saliva. (PubMed id 8340398)^{1, 2, 9} Freije J.P.... Lopez-Otin C. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level. (PubMed id 8444475)^{1, 2} Balbin M.... Lopez-Otin C. (1993)
Cystatin D is a candidate tumor suppressor gene induc ed by vitamin D in human colon cancer cells. (PubMed id 19662683)^{1, 9} Alvarez-DA-az S....MuA+oz A. (2009)
Localization of the human cystatin D gene (CST5) to chromosome 20p11.21 by in situ hybridization. (PubMed id 8422752)^{1, 9} Freije J.P....Lopez-Otin C. (1993)
Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry. (PubMed id 20189825)^{2, 9} Ryan C.M....Whitelegge J.P. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1473	HGNC: 2477	AceView: CST5	Ensembl:ENSG00000170367	euGenes: HUgn1473
ECgene: CST5	Kegg: 1473	H-InvDB: CST5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CST5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CST5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CST5 gene:
Search GeneIP for patents involving CST5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CST5 (Cystatin D)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for CST5 (Cystatin D)

	Browse OriGene Antibodies		OriGene shRNA RFP for CST5
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CST5		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CST5
	OriGene Protein Over-expression Lysate for CST5		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CST5		OriGene 3'-UTR Clone for CST5
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CST5		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CST5
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CST5		OriGene Custom Protein Services for CST5
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CST5
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CST5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CST5
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST5
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CST5

	GenScript Custom Purified and Recombinant Proteins Services for CST5		GenScript cDNA clones with any tag delivered in your preferred vector for CST5
	GenScript Custom Assay Services for CST5		GenScript Custom Superior Antibodies Services for CST5
	GenScript Custom overexpressing Cell Line Services for CST5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CST5 promoter
	Search Chromatin IP Primers for CST5
	RT² qPCR Primer Assay in human, mouse, rat CST5
	Search GNC Networks for CST5
	SABiosciences Custom PCR Arrays for CST5

Search Tocris compounds for CST5

	Proteins and Antibodies for CST5
	cDNA Clones for CST5
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CST5 antibodies
	CST5 proteins
	CST5 lysates

	Search for Antibodies for CST5 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CST5
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CST5 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CST5

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST5

	SwitchGear 3'UTR luciferase reporter plasmids for CST5
	SwitchGear Promoter luciferase reporter plasmids for CST5

Search ThermoFisher Antibodies for CST5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST5

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CST5 gene at Home site.

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CST5 Gene

cystatin D

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CST5 Gene

cystatin D

Aliasesfor CST5 gene

Summariesfor CST5 gene

Genomic Viewsfor CST5 gene

Proteinsfor CST5 gene

Protein Domains /Familiesfor CST5 gene

Functionfor CST5 gene

Pathways & Interactionsfor CST5 gene

Drugs & Compoundsfor CST5 gene

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Expression for CST5 gene

Orthologsfor CST5 gene

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Genomic Variantsfor CST5 gene

Disorders / Diseasesfor CST5 gene

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External Searches for CST5 gene

Genome Databases showing CST5 gene

Other Databases showing CST5 gene

Specialized Databases showing CST5 gene

Intellectual Propertyfor CST5 gene

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View Random Gene

Aliases
for CST5 gene

Summaries
for CST5 gene

Genomic Views
for CST5 gene

Proteins
for CST5 gene

Protein Domains /
Families
for CST5 gene

Function
for CST5 gene

Pathways & Interactions
for CST5 gene

Drugs & Compounds
for CST5 gene

Transcripts
for CST5 gene

Expression
for CST5 gene

Orthologs
for CST5 gene

Paralogs
for CST5 gene

Genomic Variants
for CST5 gene

Disorders / Diseases
for CST5 gene

Publications
for CST5 gene

Intellectual Property
for CST5 gene

Products
for CST5 gene