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CST3 Gene

protein-coding   GIFtS: 66

GC20M023562
cystatin C
(Previous name: cystatin C (amyloid angiopathy and cerebral hemorrhage) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for CST3

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
ARMD11 2, 5
Cystatin-3 3
Gamma-trace 3
MGC117328 2
OTTHUMP00000030440 2
OTTHUMP00000164181 2
OTTHUMP00000164182 2
Post-gamma-globulin 3
gamma-trace 2
post-gamma-globulin 2
Descriptions
Neuroendocrine basic polypeptide 2, 3
bA218C14.4 (cystatin C) 2
cystatin 3 2
cystatin C 2
cystatin C (amyloid angiopathy and cerebral hemorrhage) 1, 2
External Ids
HGNC: 24751
Entrez Gene: 14712
UniProtKB: P010343
Ensembl: ENSG000001014397
Search outside databases for aliases for CST3 gene

Previous GC identifers: GC20M023602 GC20M023609

Summaries
for CST3

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for CST3:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some
of the members are active cysteine protease inhibitors, while others have lost or perhaps never
acquired this inhibitory activity. There are three inhibitory families in the superfamily,
including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin
proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and
secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20
contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the
cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which
is found in high concentrations in biological fluids and is expressed in virtually all organs of
the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this
protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and
aneurysmal aortic lesions, establishing its role in vascular disease. [provided by RefSeq]

UniProtKB/Swiss-Prot: CYTC_HUMAN, P01034
Function: As an inhibitor of cysteine proteinases, this protein is thought to serve an important
physiological role as a local regulator of this enzyme activity

Gene Wiki entry for CST3 (Cystatin_C)

Genomic Location
for CST3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CST3 gene  

Entrez Gene cytogenetic band: 20p11.21   Ensembl cytogenetic band:  20p11.21   HGNC cytogenetic band: 20p11.2

CST3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M023562:     (about GC identifiers)

Start:
 23,556,534 bp from pter
End:
 23,567,110 bp from pter
Size:
 10,577 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000020.9  NT_011387.8  

Proteins
for CST3

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: CYTC_HUMAN, P01034 (See protein sequence)
Recommended Name: Cystatin-C precursor  
Size: 146 amino acids; 15799 Da
Subunit: Homodimer
Subcellular location: Secreted
Miscellaneous: Potential cerebrospinal fluid marker for the diagnosis of Creutzfeldt-Jakob disease
PDB structures from and Proteopedia :
1G96 (3D)    1R4C (3D)    1TIJ (3D)    
Secondary accessions: B2R5J9 Q6FGW9

REFSEQ proteins: NP_000090.1  

ENSEMBL proteins: 
ENSP00000381446 ENSP00000366124 ENSP00000381448 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
R&D Systems Recombinant & Natural Proteins for CST3 (Cystatin C)
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Cystatin C)
Human Recombinant Proteins from Abnova (CST3)
              OriGene Purified Recombinant Human Protein: CST3 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005615 extracellular space IDA18613859
About this table

Antibodies for CST3: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of CST3
Sigma-Aldrich Antibodies for CST3
R&D Systems Antibodies for CST3 (Cystatin C)
Antibodies from Abcam (Cystatin C), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Novus Biologicals Antibodies for CST3

Assays for CST3: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
R&D Systems ELISAs for CST3 (Cystatin C)         (see all)
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for CST3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro domains/families:
 IPR018073 Prot_inh_cystat_CS
 IPR000010 Prot_inh_cystat


   GeneDecks  CST3 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P01034

ProtoNet protein and cluster: P01034

2 Blocks protein families:
IPB000010 Cysteine protease inhibitor
IPB003243 Proteinase inhibitor I25A and I25B


UniProtKB/Swiss-Prot: CYTC_HUMAN, P01034
Similarity: Belongs to the cystatin family

Gene Function
for CST3

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (CST3)
Millipore RNAi Products for the Analysis of CST3 Gene knock-down
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000099

              Applied Biosystems Silencer® siRNAs for CST3

              Sigma-Aldrich siRNA and siRNA Panels for CST3  
                     Sigma-Aldrich shRNA for CST3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for CST3
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000099
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000099
                                 untagged cDNA clone in CMV expression vector: NM_000099 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_000099

UniProtKB/Swiss-Prot: CYTC_HUMAN, P01034
Function: As an inhibitor of cysteine proteinases, this protein is thought to serve an important
physiological role as a local regulator of this enzyme activity

Genatlas biochemistry entry for CST3:
cystatin C,cysteine proteinase inhibitor,found at high levels in saliva,tears,seminal plasma,type 2
family,expressed in all cellular types,inhibitor of cathepsin B

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cst3):

homeostasis/metabolismmusclenervous systemtumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0001540 beta-amyloid binding IPI18026102
GO:0002020 protease binding IPI6203523 7890620
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA--
About this table

Pathways & Interactions
for CST3

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Millipore Pathway for CST3
 Metalloproteases in connective tissue degradation

   GeneDecks  CST3 for the pathways selected above  
About GeneDecksing

 Gene Network CentralTM Interacting Genes and Proteins Network for  CST3 


5/47 Interacting proteins for CST3 (ENSP000003661243 P010342) via UniProtKB, MINT, and/or STRING (see all 47 )
InteractantInteraction Details
GeneCardExternal ID(s)
ATXN1P542532MINT-2857882
CTSBENSP000003456723STRING (score=.994)
CTSL1ENSP000003650733STRING (score=.983)
CTSSENSP000003579813STRING (score=.974)
APOEENSP000002524863STRING (score=.922)
About this table

5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0006952 defense response IDA6203523
GO:0010466 negative regulation of peptidase activity IDA6203523 7890620
GO:0010703 negative regulation of histolysis IC7890620
GO:0010711 negative regulation of collagen catabolic process IEP10545518
GO:0010716 negative regulation of extracellular matrix disassembly IEP10545518
About this table

Drugs & Compounds
for CST3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CST3
10/37 Novoseek chemical compound relationships for CST3 gene (see all 37 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
actinidin 69.85 7 1731767 (4), 8166644 (1), 2049069 (1), 7887904 (1)
inulin 68.49 16 11849470 (2), 16582575 (2), 10794756 (1), 17366002 (1) (see all 13)
51-cr-edta 63.88 7 15719405 (3), 10452279 (1), 17366002 (1), 18793543 (1) (see all 5)
hcca 58.55 1 2122580 (1)
homocysteine 45.54 20 12162587 (3), 10479668 (2), 18057891 (2), 11427458 (1) (see all 15)
urea 37.36 16 16337174 (3), 11772976 (2), 16025834 (1), 11961366 (1) (see all 12)
polysulfone 32.01 4 15750984 (1), 15814541 (1), 17050637 (1)
gold 31.26 8 17210589 (1), 15961546 (1), 16277744 (1), 16337174 (1) (see all 7)
uric acid 21.99 13 17852800 (2), 11763416 (2), 16444458 (1), 17313784 (1) (see all 10)
latex 21.71 6 18454664 (1), 18780660 (1), 8586116 (1), 8587256 (1) (see all 5)
About this table


Transcripts
for CST3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (CST3)
Millipore RNAi Products for the Analysis of CST3 Gene knock-down
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000099

              Sigma-Aldrich siRNA and siRNA Panels for CST3  
                     Sigma-Aldrich shRNA for CST3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_000099  

REFSEQ mRNAs for CST3 gene: 

NM_000099.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_000099  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000099
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000099
                                 untagged cDNA clone in CMV expression vector: NM_000099 

Additional cDNA sequence: 

AK312213.1 BC013083.1 BC110305.1 BT006839.1 BX647523.1 CR541988.1 CR542018.1 CR590218.1 
CR601605.1 CR606174.1 CR612887.1 CR622151.1 X05607.1 

21 DOTS entries:

DT.100877072  DT.455557  DT.91763237  DT.95093929  DT.91723478  DT.100877079  DT.95093846  DT.100045036 
DT.95093848  DT.95297684  DT.97864557  DT.102830035  DT.91726513  DT.91763249  DT.92042672  DT.95093928 
DT.95242542  DT.100877078  DT.86996545  DT.91763245  DT.97788404 

24/1038 AceView cDNA sequences (see all 1038 ):

BM686702 CR601605 BQ029881 F36915 H22416 BM768342 AI304612 AW880787 
AW069713 BF195379 BM973156 CA418793 AA320404 BQ637911 BQ574579 CA418561 
BM707113 BM852193 T29906 AW474084 BU947691 AL698469 BM708828 BI823017 

highest scoring ESTs for CST3:

AA086142 AA284648 AA291655 AA315198 AA325184 AA335397 AA336083 AA363573 AA364028 AA365044 

Unigene Cluster for CST3:

Cystatin C
Hs.304682  [show with all ESTs]
Unigene Representative Sequence: BX647523


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CST3

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1:        -     -     -                       -                     
SP2:                                            -                     
SP3:                                            -                     
SP4:                                                                  

About this scheme

ECgene alternative splicing isoforms for CST3

3 Ensembl transcripts including schematic representations:
ENST00000398409  ENST00000376925  ENST00000398411  

Expression
for CST3

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CST3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for CST3

1 / 2 / 3

5 probe-sets matching CST3 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

73122_at2, 3 U95-E 1 0.38 1.00 1.00 1.00 AW051500 0.60 1.00 0.82 1

237623_at2, 3 U133-B 1 1.00 1.00 -- -- AI829605 0.40 1.00 0.76 1

201360_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000099 0.60 1.00 0.82 1

237623_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

201360_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TGCCTGCACC

SOURCE GeneReport for Unigene cluster: Hs.304682

Expression variation in blood from EXPOLDB for CST3

UniProtKB/Swiss-Prot: CYTC_HUMAN, P01034
Tissue specificity: Found in various body fluids, such as the cerebrospinal fluid and plasma.
Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the
lowest in the submandibular gland

Orthologs
for CST3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for CST3 gene from 4 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
cow
(Bos taurus)		 CST31   -- cystatin C 75.46(n)
68.75(a)		 281102  NM_174029.1  NP_776454.1 
rat
(Rattus norvegicus)		 Cst31   -- cystatin C 75.71(n)
73.57(a)		 25307  NM_012837.1  NP_036969.1 
mouse
(Mus musculus)		 Cst31, 5 2 (84.00 cM)5
 cystatin C1, 5 75.71(n)1
72.14(a)1		 130101  NM_009976.31  NP_034106.21 
 AF3117415  AF4834865  (see all 22)
chicken
(Gallus gallus)		 CST31   -- cystatin C 55.64(n)
43.88(a)		 396497  NM_205500.1  NP_990831.1 
About this table        Species with no ortholog for CST3

ENSEMBL Gene Tree for CST3

Paralogs
for CST3

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for CST3 gene
CST42  CST22  CST82  CSTL12  CST12  RP11-218C14.62  CST52  CST112  

SNPs/Variants
for CST3

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/78 NCBI SNPs in CST3 are shown (see all 78 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 46)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 20 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs38271431,2
A,C,F,H23567617(+) AGGCCA/GCAGGA 1 -- ng318Minor allele frequency- G:0.18EU EA WA 836
--
rs24245801,2
A,C,F,H23567543(+) TCTTCG/AGAGGT 1 -- ng314Minor allele frequency- A:0.06EU EA WA 398
rs24245781,2
A,C,F,H23562087(+) CTCAAC/TGCCTT 1 -- ng514Minor allele frequency- T:0.04EU EA WA 412
--
rs37612801,2
A,C23568076(+) caagcA/Gccctg 1 -- ng310--------
--
rs32092611,2
C,F23562518(-) CACCTC/TTTATG 1 -- ut311Minor allele frequency- T:0.03MN 184
--
rs10591371,2
C23562355(-) TGCTTC/TTCATA 1 -- ut31 ese31Minor allele frequency- T:0.00MN 184
--
rs37612791,2
C23568075(+) tcaagC/Gaccct 1 -- ng310--------
--
rs115041,2
F23562470(-) GTGGCA/CCCTGC 1 -- ut31 ese31Minor allele frequency- C:0.29MN 184
--
rs60489621,2
A23567359(+) tgcccC/Tccttc 1 -- ng31 tfbs3 trp30--------
--
rs147671,2
C23562396(-) TTGTTG/ACTCAG 1 -- ut311Minor allele frequency- A:0.00MN 184
About this table

HapMap Linkage Disequilibrium images for CST3 (up to first 250kb)

Disorders & Mutations
for CST3

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 604312   disorders: 105150  611953  

UniProtKB/Swiss-Prot: CYTC_HUMAN, P01034

  • Defects in CST3 are the cause of amyloidosis type 6 (AMYL6) [MIM:105150]; also known as
    hereditary cerebral hemorrhage with amyloidosis (HCHWA), cerebral amyloid angiopathy (CAA) or
    cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to
    cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries,
    arterioles, and sometimes capillaries and veins of the brain, and in various organs including
    lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral
    vessels results in cerebral amyloid angiopathy, cerebral hemorrage and premature stroke. Cystatin
    C levels in the cerebrospinal fluid are abnormally low
  • Genetic variations in CST3 are associated with age-related macular degeneration type 11
    (ARMD11) [MIM:611953]. ARMD is a multifactorial eye disease and the most common cause of
    irreversible vision loss in the developed world. In most patients, the disease is manifest as
    ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the
    retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane

    • 10/91 Novoseek disease relationships for CST3 gene (see all 91 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerebral amyloid angiopathy 81.15 33 8711812 (4), 1853405 (4), 11760381 (2), 2364630 (2) (see all 17)
    renal disease 80.13 115 16908914 (8), 16408133 (4), 19374014 (3), 18434750 (2) (see all 79)
    kidney dysfunction 73.78 15 16609294 (3), 15603510 (1), 18226769 (1), 16870638 (1) (see all 12)
    sporadic cerebral amyloid angiopathy 71.33 5 11094619 (1), 11760381 (1), 9493177 (1)
    intracerebral hemorrhage 65.35 28 2364630 (4), 8085435 (3), 7482672 (3), 9063500 (2) (see all 16)
    cerebral amyloid angiopathy familial 62.62 1 15152461 (1)
    amyloid deposition 60.65 8 1517744 (1), 8685920 (1), 9860845 (1), 18026100 (1) (see all 6)
    amyloidosis 60.37 19 8085435 (2), 9063500 (1), 15904486 (1), 2201197 (1) (see all 17)
    microalbuminuria 59.61 21 17205961 (3), 16232367 (2), 17720520 (2), 15782299 (1) (see all 14)
    brain hemorrhage 59.58 7 1853405 (4), 2408196 (1), 17470433 (1), 2169252 (1)
    About this table

    Human Gene Mutation Database: CST3
    Genetic Association Database: CST3
    Human Genome Epidemiology Navigator: CST3 (26 documents)

    Medical News
    for CST3

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for CST3

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/709 PubMed articles for CST3 gene (see all 709 ):

    Search for CST3

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CST3

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 1471 HGNC: 2475 AceView: CST3 Ensembl:ENSG00000101439 euGenes: HUgn1471
    ECgene: CST3 H-InvDB: CST3

    Other Databases showing CST3

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing CST3

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for CST3 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for CST3

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for CST3

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for CST3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for CST3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for CST3 Antibodies for CST3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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     Search Tocris compounds for CST3




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for CST3

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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