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Aliases for CST2 Gene

Aliases for CST2 Gene

  • Cystatin SA 2 3
  • Cystatin-S5 3 4
  • Cystatin 2 2 3
  • Cystatin-2 3 4
  • Salivary Cysteine (Thiol) Protease Inhibitor 3
  • Cysteine-Proteinase Inhibitor 3
  • Cystatin S5 3
  • Cystatin-SA 3

External Ids for CST2 Gene

Previous GeneCards Identifiers for CST2 Gene

  • GC20M023792
  • GC20M023799
  • GC20M023752

Summaries for CST2 Gene

Entrez Gene Summary for CST2 Gene

  • The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. [provided by RefSeq, Jul 2008]

GeneCards Summary for CST2 Gene

CST2 (Cystatin SA) is a Protein Coding gene. Diseases associated with CST2 include autoimmune polyendocrine syndrome type 1. Among its related pathways are Salivary secretion. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST8.

UniProtKB/Swiss-Prot for CST2 Gene

  • Thiol protease inhibitor

Gene Wiki entry for CST2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CST2 Gene

Genomics for CST2 Gene

Regulatory Elements for CST2 Gene

Transcription factor binding sites by QIAGEN in the CST2 gene promoter:

Genomic Location for CST2 Gene

Start:
23,823,767 bp from pter
End:
23,826,731 bp from pter
Size:
2,965 bases
Orientation:
Minus strand

Genomic View for CST2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CST2 Gene

Proteins for CST2 Gene

  • Protein details for CST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09228-CYTT_HUMAN
    Recommended name:
    Cystatin-SA
    Protein Accession:
    P09228
    Secondary Accessions:
    • Q9UCQ7

    Protein attributes for CST2 Gene

    Size:
    141 amino acids
    Molecular mass:
    16445 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CST2 Gene

Proteomics data for CST2 Gene at MOPED

Post-translational modifications for CST2 Gene

No Post-translational modifications

Other Protein References for CST2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CST2 Gene

Domains for CST2 Gene

Suggested Antigen Peptide Sequences for CST2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09228

UniProtKB/Swiss-Prot:

CYTT_HUMAN :
  • P09228
Family:
  • Belongs to the cystatin family.
genes like me logo Genes that share domains with CST2: view

No data available for Gene Families for CST2 Gene

Function for CST2 Gene

Molecular function for CST2 Gene

GENATLAS Biochemistry: cystatin SA,cysteine proteinase inhibitor,found at high levels in saliva,tears,seminal plasma,type 2 family,including two variants cystatin SA1 and cystatin SA2
UniProtKB/Swiss-Prot Function: Thiol protease inhibitor

Gene Ontology (GO) - Molecular Function for CST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CST2: view

Animal Model Products

miRNA for CST2 Gene

miRTarBase miRNAs that target CST2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CST2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CST2 Gene

Localization for CST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CST2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CST2 Gene COMPARTMENTS Subcellular localization image for CST2 gene
Compartment Confidence
extracellular 5
cytosol 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
genes like me logo Genes that share ontologies with CST2: view

Pathways for CST2 Gene

SuperPathways for CST2 Gene

Superpath Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with CST2: view

Pathways by source for CST2 Gene

1 KEGG pathway for CST2 Gene

Gene Ontology (GO) - Biological Process for CST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0010951 negative regulation of endopeptidase activity TAS 3446578
genes like me logo Genes that share ontologies with CST2: view

Compounds for CST2 Gene

(2) Novoseek inferred chemical compound relationships for CST2 Gene

Compound -log(P) Hits PubMed IDs
kininogen 73.9 2
cysteine 72.7 14
genes like me logo Genes that share compounds with CST2: view

Transcripts for CST2 Gene

mRNA/cDNA for CST2 Gene

(25) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CST2 Gene

Cystatin SA:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CST2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CST2 Gene

No ASD Table

Relevant External Links for CST2 Gene

GeneLoc Exon Structure for
CST2
ECgene alternative splicing isoforms for
CST2

Expression for CST2 Gene

mRNA expression in normal human tissues for CST2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CST2 Gene

This gene is overexpressed in Adrenal Gland (16.5), Cervix - Ectocervix (7.2), Cervix - Endocervix (5.0), and Prostate (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CST2 Gene

SOURCE GeneReport for Unigene cluster for CST2 Gene Hs.669305

mRNA Expression by UniProt/SwissProt for CST2 Gene

P09228-CYTT_HUMAN
Tissue specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in submandibular gland and parotid gland.
genes like me logo Genes that share expressions with CST2: view

In Situ Assay Products

Orthologs for CST2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CST2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CST2 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CST3 36
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cst10 36
  • 37 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-3526 36
  • 37 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cst3 36
  • 30 (a)
ManyToMany
Species with no ortholog for CST2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CST2 Gene

ENSEMBL:
Gene Tree for CST2 (if available)
TreeFam:
Gene Tree for CST2 (if available)

Paralogs for CST2 Gene

Paralogs for CST2 Gene

Selected SIMAP similar genes for CST2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CST2: view

Variants for CST2 Gene

Sequence variations from dbSNP and Humsavar for CST2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs4239738 -- 23,827,967(+) CCTGG(A/T)GTCTC upstream-variant-2KB
rs4365536 -- 23,827,594(+) AATTC(A/G)CTGTG upstream-variant-2KB
rs4378872 -- 23,827,704(+) CTACA(C/T)AGTGT upstream-variant-2KB
rs4407312 -- 23,826,391(+) CAAAC(A/C)AGGCT intron-variant
rs4432530 -- 23,827,897(+) GTGGG(A/G)TTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CST2 Gene

Variant ID Type Subtype PubMed ID
dgv698e201 CNV Deletion 23290073
esv2722309 CNV Deletion 23290073
nsv458953 CNV Loss 19166990
dgv783e199 CNV Deletion 23128226
esv2722310 CNV Deletion 23290073
nsv912823 CNV Gain 21882294
nsv436326 CNV Deletion 17901297
nsv3336 CNV Loss 18451855
nsv833944 CNV Gain 17160897

Relevant External Links for CST2 Gene

HapMap Linkage Disequilibrium report
CST2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CST2 Gene

Disorders for CST2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CST2 Gene including...

Search for CST2 Gene in MalaCards »

Relevant External Links for CST2

Genetic Association Database (GAD)
CST2
Human Genome Epidemiology (HuGE) Navigator
CST2
genes like me logo Genes that share disorders with CST2: view

No data available for UniProtKB/Swiss-Prot for CST2 Gene

Publications for CST2 Gene

  1. Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S. (PMID: 1778989) Isemura S. … Minakata K. (J. Biochem. 1991) 3 4 23
  2. Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular gland. (PMID: 11879580) Dickinson D.P. … Hicks M.J. (DNA Cell Biol. 2002) 3 4 23
  3. Sac I Restriction Fragment Length Polymorphism (RFLP) related to the human CST2 gene. (PMID: 12013824) Minaguchi K. … Sanada K. (Bull. Tokyo Dent. Coll. 2002) 3 23 48
  4. Salivary cystatins induce interleukin-6 expression via cell surface molecules in human gingival fibroblasts. (PMID: 12413693) Kato T. … Okuda K. (Mol. Immunol. 2002) 3 23
  5. Murine monoclonal antibody which can distinguish cystatins SA1 and SA2. (PMID: 15829315) Ito T. … Kato T. (Mol. Immunol. 2005) 3 23

Products for CST2 Gene

Sources for CST2 Gene

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