CST2 Gene
protein-coding GIFtS : 51
GCID: GC20 M023805
cystatin SA
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Aliasesfor CST2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Cystatin SA 1 2 Cystatin-SA1 Cystatin 22 Cysteine-Proteinase Inhibitor2 Cystatin S52 Salivary Cysteine (Thiol) Protease Inhibitor2 Cystatin-23 Cystatin-23 Cystatin-S53 Cystatin-S53
Export aliases for CST2 gene to outside databases Previous GC identifers: GC20M023792 GC20M023799 GC20M023752
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Summariesfor CST2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CST2 : The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: CYTT_HUMAN, P09228 Function : Thiol protease inhibitorGene Wiki entry for CST2
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Genomic Viewsfor CST2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000020.10 NC_018931.1 NT_011387.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CST2 gene promoter: Zic1 Nkx5-1 Other transcription factors Search SABiosciences Chromatin IP Primers for CST2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 20p11.21 Ensembl cytogenetic band: 20p11.21 HGNC cytogenetic band: 20p11.2 CST2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20M023805: view genomic region
(about GC identifiers )
Start:
23,804,404 bp from pter
End:
23,807,368 bp from pter
Size:
2,965 bases
Orientation:
minus strand
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Proteinsfor CST2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CYTT_HUMAN, P09228 (See
protein sequence )Recommended Name: Cystatin-SA precursor Size : 141 amino acids; 16445 Da
Subcellular location : Secreted
Mass spectrometry : Mass=14336.9856; Mass_error=0.0158; Method=Electrospray; Range=21-141; Source=PubMed:20189825;
Secondary accessions : Q9UCQ7Explore the universe of human proteins at neXtProt for CST2: NX_P09228 CST2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001313.1 ENSEMBL proteins: ENSP00000307540 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA --
CST2 for ontologies About GeneDecksing CST2 Antibody Products: Assay Products for CST2:
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Protein
Domains / Familiesfor CST2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CST2 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P09228 ProtoNet protein and cluster: P09228
2 Blocks protein families : IPB000010 Cysteine protease inhibitor IPB003243 Proteinase inhibitor I25A and I25B UniProtKB/Swiss-Prot: CYTT_HUMAN, P09228 Similarity : Belongs to the cystatin family
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Functionfor CST2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CYTT_HUMAN, P09228 Function : Thiol protease inhibitor
Genatlas biochemistry entry for CST2 : cystatin SA,cysteine proteinase inhibitor,found at high levels in saliva,tears,seminal plasma,type 2 family,including two variants cystatin SA1 and cystatin SA2 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CST2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CST2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CST2 (NM_001322 ) Sino Biological Human cDNA Clone for CST2 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CST2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CST2
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004869 cysteine-type endopeptidase inhibitor activity
IEA --
CST2 for ontologies About GeneDecksing
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Pathways & Interactionsfor CST2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Gastric acid secretion
Pathway sources See GeneCards unified pathways Show all pathways 1
Kegg Pathway (Kegg details for CST2) :
CST2 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CST2
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Drugs & Compoundsfor CST2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
CST2 for compounds About GeneDecksing Browse Tocris compounds for CST2 2 Novoseek chemical compound relationships for CST2 gene About this table
Search CenterWatch for drugs/clinical trials and news about CST2 / CYTT
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Transcriptsfor CST2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CST2 gene: NM_001322.2 Unigene Cluster for CST2:
Cystatin SA Hs.669305 [show with all ESTs ] Unigene Representative Sequence: BQ683774 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000304725 (uc002wtq.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CST2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CST2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CST2 (NM_001322 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CST2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CST2
Additional cDNA sequence: BC062679.1
4 DOTS entries : DT.70101451 DT.97759874
DT.100678518 DT.120823070 24/25 AceView cDNA sequences (see all 25 ):
CK905411 NM_001322 CK905410 BP334327 CB959441 BC062679 BP334646 BP334323 BP334783 BP334681 BQ683774 BP334802 BP335077 BP334571 BP335021 AI521546 BP334367 BP334101 BM509439 CD611299 AW117764 BP334115 BM509192 BP334272 GeneLoc Exon Structure
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Expression for CST2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CST2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTACACACAC
About this image CST2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See CST2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CST2 SOURCE GeneReport for Unigene cluster: Hs.669305 UniProtKB/Swiss-Prot: CYTT_HUMAN, P09228 Tissue specificity : Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level).Expressed in submandibular gland and parotid gland SABiosciences Custom PCR Arrays for CST2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CST2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat CST2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CST2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CST2
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Orthologsfor CST2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for CST2 gene from 3/7 species (see all 7 ) About this table
ENSEMBL Gene Tree for CST2 (if available)TreeFam Gene Tree for CST2 (if available)
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Paralogsfor CST2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CST2 gene CSTL1 2 CST7 2 CST1 2 CST3 2 CST6 2 CST4 2 CST8 2 CST5 2 CST11 2 10 SIMAP similar genes for CST2 using alignment to 1 protein entry: CYTT_HUMAN :CST1 CST4 CST5 CST3 CST11 CSTL1 CST8 CST6 CST9LP1 CST9L
CST2 for paralogs About GeneDecksing
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Genomic Variantsfor CST2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 20 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CST2 (23804404 - 23807368 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for CST2 2 CNVs : 5129 22932
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CST2
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Disorders
/ Diseasesfor CST2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CST2 for disorders About GeneDecksing
OMIM gene information: 123856
OMIM disorders : --5 diseases for CST2 : About MalaCards cerebral hemorrhage epididymitis gingivitis cerebritis periodontitis Genetic Association Database (GAD): CST2 Human Genome Epidemiology (HuGE) Navigator: CST2 (3 documents) Export disorders for CST2 gene to outside databases
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Publicationsfor CST2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CST2 gene, integrated from 9 sources (see all 67 ): (articles sorted by number of sources associating them with CST2) Utopia : connect your pdf to the dynamic world of online information
Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S. (PubMed id 1778989) 1 , 2 , 9 Isemura S.... Minakata K. (1991) Sac I Restriction Fragment Length Polymorphism (RFLP) related to the human CST2 gene. (PubMed id 12013824) 1 , 4, 9 Minaguchi K....Sanada K. (2002) Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular gland. (PubMed id 11879580) 1 , 2 , 9 Dickinson D.P....Hicks M.J. (2002) Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161) 1 , 2 Zhang Z. and Henzel W.J. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052) 1 , 2 Deloukas P....Rogers J. (2001) Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes. (PubMed id 3202964) 1 , 2 Saitoh E.... Maeda N. (1988) Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family. (PubMed id 3446578) 1 , 2 Saitoh E.... Maeda N. (1987) Characterization and amino acid sequence of a new acidic cysteine proteinase inhibitor (cystatin SA) structurally closely related to cystatin S, from human whole saliva. (PubMed id 3436950) 1 , 2 Isemura S.... Sanada K. (1987) Murine monoclonal antibody which can distinguish cystatins SA1 and SA2. (PubMed id 15829315) 1 , 9 Ito T....Kato T. (2005)
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External Searches for CST2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CST2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CST2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CST2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CST2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CST2 gene: Search GeneIP for patents involving CST2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CST2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for CST2 OriGene shRNA RFP for CST2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CST2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CST2 OriGene Protein Over-expression Lysate for CST2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CST2 OriGene 3'-UTR Clone for CST2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CST2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CST2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for CST2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CST2 OriGene Custom Protein Services for CST2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CST2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CST2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CST2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CST2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CST2
Search Tocris compounds for CST2
CST2 Proteins, Antibodies, CLIAs, and ELISAs
Search ThermoFisher Antibodies for CST2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CST2
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Aliases for CST2
Databases for CST2
Disorders / Diseases for CST2
Domains / Families for CST2
Drugs / Compounds for CST2
Expression for CST2
Function for CST2
Genomic Views for CST2
Intellectual Property for CST2
Orthologs for CST2
Paralogs for CST2
Pathways / Interactions for CST2
Products for CST2
Proteins for CST2
Publications for CST2
Search Box for CST2
Summaries for CST2
Transcripts for CST2
Variants for CST2
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