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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CST2 Gene

protein-coding   GIFtS: 51
GCID: GC20M023805

Cystatin SA

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cystatin SA1 2     cystatin-SA2
Cystatin 21 2     Cysteine-Proteinase Inhibitor2
Cystatin S52     Salivary Cysteine (Thiol) Protease Inhibitor2
cystatin-22     Cystatin-23
cystatin-S52     Cystatin-S53

External Ids:    HGNC: 24741   Entrez Gene: 14702   Ensembl: ENSG000001703697   OMIM: 1238565   UniProtKB: P092283   

Export aliases for CST2 gene to outside databases

Previous GC identifers: GC20M023792 GC20M023799 GC20M023752


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CST2 Gene:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members
are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory
activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type
2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found
in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin
locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located
in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and
seminal plasma. (provided by RefSeq, Jul 2008)

GeneCards Summary for CST2 Gene: 
CST2 (cystatin SA) is a protein-coding gene. Diseases associated with CST2 include cerebral hemorrhage, and epididymitis, and among its related super-pathways are Gastric acid secretion. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST4.

UniProtKB/Swiss-Prot: CYTT_HUMAN, P09228
Function: Thiol protease inhibitor

Gene Wiki entry for CST2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CST2 gene promoter:
         Zic1   Nkx5-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCST2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CST2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.21   Ensembl cytogenetic band:  20p11.21   HGNC cytogenetic band: 20p11.2

CST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CST2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M023805:  view genomic region     (about GC identifiers)

Start:
23,804,404 bp from pter      End:
23,807,368 bp from pter
Size:
2,965 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CYTT_HUMAN, P09228 (See protein sequence)
Recommended Name: Cystatin-SA precursor  
Size: 141 amino acids; 16445 Da
Subcellular location: Secreted
Mass spectrometry: Mass=14336.9856; Mass_error=0.0158; Method=Electrospray; Range=21-141; Source=PubMed:20189825;
Secondary accessions: Q9UCQ7

Explore the universe of human proteins at neXtProt for CST2: NX_P09228

Explore proteomics data for CST2 at MOPED 

CST2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CST2 Protein Expression

REFSEQ proteins: NP_001313.1  
ENSEMBL proteins: 
 ENSP00000307540  

Human Recombinant Protein Products for CST2: 
Browse Purified and Recombinant Proteins at EMD Millipore
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Sino Biological Cell Lysate for CST2 
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Cloud-Clone Corp. Proteins for CST2 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

CST2 for ontologies           About GeneDecksing



CST2 Antibody Products: 
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Cloud-Clone Corp. CLIAs for CST2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR018073 Prot_inh_cystat_CS
 IPR000010 Prot_inh_cystat
 IPR027214 Cystatin

Graphical View of Domain Structure for InterPro Entry P09228

ProtoNet protein and cluster: P09228

2 Blocks protein domains:
IPB000010 Cysteine protease inhibitor
IPB003243 Proteinase inhibitor I25A and I25B


UniProtKB/Swiss-Prot: CYTT_HUMAN, P09228
Similarity: Belongs to the cystatin family


CST2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CYTT_HUMAN, P09228
Function: Thiol protease inhibitor

     Genatlas biochemistry entry for CST2:
cystatin SA,cysteine proteinase inhibitor,found at high levels in saliva,tears,seminal plasma,type 2
family,including two variants cystatin SA1 and cystatin SA2

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004869cysteine-type endopeptidase inhibitor activity IEA--
     
CST2 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CST2 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CST2 
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miRNA
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SwitchGear 3'UTR luciferase reporter plasmidCST2 3' UTR sequence
Inhib. RNA
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Gene Editing
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Clone
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Sino Biological Human cDNA Clone for CST2
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST2
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CST2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Gastric acid secretion
Salivary secretion0.34

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways




1         Kegg Pathway  (Kegg details for CST2):
    Salivary secretion


CST2 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CST2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CST2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CST2 (CYTT)

2 Novoseek inferred chemical compound relationships for CST2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
kininogen 73.9 4 2338365 (1), 2107324 (1)
cysteine 72.7 14 12586767 (2), 15196002 (1), 15603510 (1), 9099741 (1) (see all 13)

Search CenterWatch for drugs/clinical trials and news about CST2 / CYTT

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CST2 gene: 
NM_001322.2  

Unigene Cluster for CST2:

Cystatin SA
Hs.669305  [show with all ESTs]
Unigene Representative Sequence: BQ683774
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000304725(uc002wtq.1)
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidCST2 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CST2
Clone
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST2
Sirion Biotech Customized lentivirus for stable overexpression of CST2 
                     Customized lentivirus expression plasmids for stable overexpression of CST2 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CST2
OriGene qSTAR qPCR primer pairs in human, mouse for CST2
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CST2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST2

Additional mRNA sequence: BC062679.1 

4 DOTS entries:

DT.70101451  DT.100678518  DT.120823070  DT.97759874 

24/25 AceView cDNA sequences (see all 25):

NM_001322 CK905411 BP334327 CK905410 CB959441 BP334783 BP334323 BC062679 
BP334646 BP335077 BP334681 BQ683774 BP334802 BP335021 AI521546 BP334571 
BP334367 BM509439 AW117764 CD611299 BP334101 BP334115 BM509192 BP334272 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CST2 expression in normal human tissues (normalized intensities)      CST2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTACACACAC
CST2 Expression
About this image


CST2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Oral Cavity (Gastrointestinal Tract)    fully expand to see all 5 entries
         salivary gland ; glandular cells   
         salivary gland   
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
         hIPS1
 
 Mesenchymal Stem Cells (Muscoskeletal System)    fully expand to see all 2 entries
         Human Mesenchymal Stem Cells (hMSC)   
 
 Cartilage (Muscoskeletal System)
         Normal Human Articular chondrocytes (NHAC)   

See CST2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CST2

SOURCE GeneReport for Unigene cluster: Hs.669305

UniProtKB/Swiss-Prot: CYTT_HUMAN, P09228
Tissue specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level).
Expressed in submandibular gland and parotid gland

    SABiosciences Custom PCR Arrays for CST2
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CST2 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves gga-mir-35266
gga-mir-3526
36(a)
1 → many
3(14928612-14932913)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
36(a)
1 → many
4(82204275-82217421)
zebrafish
(Danio rerio)
Actinopterygii cst36
zgc:1630306
zgc:163030
32(a)
27(a)
many ↔ many
many ↔ many
13(33900031-33908388)
13(33894411-33896169)
        Species with no ortholog for CST2

ENSEMBL Gene Tree for CST2 (if available)
TreeFam Gene Tree for CST2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CST2 gene
CST42  CSTL12  CST82  CST12  CST32  CST52  CST112  
10 SIMAP similar genes for CST2 using alignment to 1 protein entry:     CYTT_HUMAN:
CST1    CST4    CST5    CST3    CST11    CSTL1
CST8    CST6    CST9LP1    CST9L

CST2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/261 SNPs in CST2 are shown (see all 261)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs61143181,2
C,F,H--23803966(+) CATTTG/ATCTAT 1 -- ds500120Minor allele frequency- A:0.25NS EA NA WA CSA 2339
rs1426470371,2
--23804046(+) TCCACC/TGAGGC 1 -- ds50010--------
rs781407431,2
C,F--23804104(+) CAGTAG/ACTCAG 1 -- ds50011Minor allele frequency- A:0.02WA 118
rs1506154391,2
C--23804133(+) CTTCCC/TGGGCA 1 -- ds50010--------
rs1894461741,2
C--23804209(+) TCCAGA/CCCCTG 1 -- ds50010--------
rs1397186101,2
--23804243(+) CTCAGA/GCCTCC 1 -- ds50010--------
rs413093451,2
C--23804265(+) CAGCTC/TCCCTG 1 -- ds50014Minor allele frequency- T:0.19CSA WA NA EA 360
rs1115361071,2
C,F--23804296(+) TCAGGT/CCCCAG 1 -- ds50012Minor allele frequency- C:0.03CSA WA 120
rs1497687801,2
C--23804328(+) AAGCAC/GAACAA 1 -- ds50010--------
rs61381231,2
C,F--23804355(+) AACTGC/TAGAAA 1 -- ds50015Minor allele frequency- T:0.07WA NA CSA 129

HapMap Linkage Disequilibrium report for CST2 (23804404 - 23807368 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for CST2:    About this table     
Variant IDTypeSubtypePubMed ID
nsv436326CNV Deletion17901297
dgv698e201CNV Deletion23290073
dgv783e199CNV Deletion23128226
esv2722309CNV Deletion23290073
esv2722310CNV Deletion23290073
nsv458953CNV Loss19166990
nsv3336CNV Loss18451855
nsv833944CNV Gain17160897
nsv912823CNV Gain21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CST2
DNA2.0 Custom Variant and Variant Library Synthesis for CST2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 123856    OMIM disorders: --

5 diseases for CST2:    About MalaCards
cerebral hemorrhage    epididymitis    gingivitis    periodontitis
cerebritis


CST2 for disorders           About GeneDecksing

Genetic Association Database (GAD): CST2
Human Genome Epidemiology (HuGE) Navigator: CST2 (3 documents)

Export disorders for CST2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CST2 gene, integrated from 9 sources (see all 68):
(articles sorted by number of sources associating them with CST2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S. (PubMed id 1778989)1, 2, 9 Isemura S.... Minakata K. (1991)
  2. Sac I Restriction Fragment Length Polymorphism (RFLP) related to the human CST2 gene. (PubMed id 12013824)1, 4, 9 Minaguchi K....Sanada K. (2002)
  3. Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular gland. (PubMed id 11879580)1, 2, 9 Dickinson D.P....Hicks M.J. (2002)
  4. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
  5. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
  6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
  9. Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes. (PubMed id 3202964)1, 2 Saitoh E.... Maeda N. (1988)
  10. Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family. (PubMed id 3446578)1, 2 Saitoh E.... Maeda N. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 1470 HGNC: 2474 AceView: CST2 Ensembl:ENSG00000170369 euGenes: HUgn1470
ECgene: CST2 Kegg: 1470 H-InvDB: CST2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CST2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CST2 gene:
Search GeneIP for patents involving CST2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for CST2 (Cystatin SA)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
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 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for CST2 (Cystatin SA)  
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 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for CST2   OriGene RNAi products in human, mouse, rat for CST2  
 OriGene qPCR primer pairs and template standards for CST2   OriGene Protein Over-expression Lysate for CST2  
 OriGene MassSpec something-or-other for CST2   OriGene clones in human, mouse for CST2  
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 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for CST2   OriGene Custom Protein Services for CST2  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CST2
 QIAGEN SeqTarget long-range PCR primers for resequencing CST2
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST2
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CST2
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST2
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CST2
 GenScript Custom Purified and Recombinant Proteins Services for CST2 GenScript cDNA clones with any tag delivered in your preferred vector for CST2
 GenScript Custom Assay Services for CST2 GenScript Custom Superior Antibodies Services for CST2
 GenScript Custom overexpressing Cell Line Services for CST2 CloneReady with Over 120,000 Genes
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 Search for Antibodies & Assays

 Regulatory tfbs in CST2 promoter
 Search Chromatin IP Primers for CST2
 RT2 qPCR Primer Assay in human, mouse / rat CST2
 Search GNC Networks for CST2
 SABiosciences Custom PCR Arrays for CST2
 Search Tocris compounds for CST2 (CYTT)
 Proteins and Antibodies for CST2
 Cell Lysates for CST2
 cDNA Clones for CST2
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 CST2 antibodies
 CST2 proteins
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 Antibodies for CST2
 See all of Abcam's Antibodies, Kits and Proteins for CST2
 Custom Antibody / Protein Production Service
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 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Proteins for CST2
 Antibodies for CST2
 ELISAs for CST2
 CLIAs for CST2
 Search LifeMap BioReagents cell lines for CST2
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST2
 SwitchGear 3'UTR luciferase reporter plasmids for CST2
 SwitchGear Promoter luciferase reporter plasmids for CST2
 Search ThermoFisher Antibodies for CST2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST2
 inGenious Targeting Laboratory - Custom generated mouse model solutions for CST2
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CST2
Customized:
 lentivirus for stable overexpression of CST2
 lentivirus expression plasmids for stable overexpression of CST2
 adenovirus for overexpression of CST2
 LSBio Antibodies in human, mouse, rat for CST2
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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