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Aliases for CST2 Gene

Aliases for CST2 Gene

  • Cystatin SA 2 3
  • Cystatin-S5 3 4
  • Cystatin 2 2 3
  • Cystatin-2 3 4
  • Salivary Cysteine (Thiol) Protease Inhibitor 3
  • Cysteine-Proteinase Inhibitor 3
  • Cystatin S5 3

External Ids for CST2 Gene

Previous GeneCards Identifiers for CST2 Gene

  • GC20M023792
  • GC20M023799
  • GC20M023752

Summaries for CST2 Gene

Entrez Gene Summary for CST2 Gene

  • The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. [provided by RefSeq, Jul 2008]

GeneCards Summary for CST2 Gene

CST2 (Cystatin SA) is a Protein Coding gene. Among its related pathways are Salivary secretion. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST8.

UniProtKB/Swiss-Prot for CST2 Gene

  • Thiol protease inhibitor

Gene Wiki entry for CST2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CST2 Gene

Genomics for CST2 Gene

Regulatory Elements for CST2 Gene

Transcription factor binding sites by QIAGEN in the CST2 gene promoter:

Genomic Location for CST2 Gene

23,823,767 bp from pter
23,826,731 bp from pter
2,965 bases
Minus strand

Genomic View for CST2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CST2 Gene

Proteins for CST2 Gene

  • Protein details for CST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q9UCQ7

    Protein attributes for CST2 Gene

    141 amino acids
    Molecular mass:
    16445 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CST2 Gene

Proteomics data for CST2 Gene at MOPED

Post-translational modifications for CST2 Gene

No Post-translational modifications

Other Protein References for CST2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CST2 Gene

Domains & Families for CST2 Gene

Gene Families for CST2 Gene

Suggested Antigen Peptide Sequences for CST2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cystatin family.
  • Belongs to the cystatin family.
genes like me logo Genes that share domains with CST2: view

Function for CST2 Gene

Molecular function for CST2 Gene

GENATLAS Biochemistry:
cystatin SA,cysteine proteinase inhibitor,found at high levels in saliva,tears,seminal plasma,type 2 family,including two variants cystatin SA1 and cystatin SA2
UniProtKB/Swiss-Prot Function:
Thiol protease inhibitor

Gene Ontology (GO) - Molecular Function for CST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CST2: view

Phenotypes for CST2 Gene

GenomeRNAi human phenotypes for CST2:
genes like me logo Genes that share phenotypes with CST2: view

miRNA for CST2 Gene

miRTarBase miRNAs that target CST2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CST2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CST2 Gene

Localization for CST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CST2 Gene


Subcellular locations from

Jensen Localization Image for CST2 Gene COMPARTMENTS Subcellular localization image for CST2 gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
genes like me logo Genes that share ontologies with CST2: view

Pathways & Interactions for CST2 Gene

SuperPathways for CST2 Gene

Superpath Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with CST2: view

Pathways by source for CST2 Gene

1 KEGG pathway for CST2 Gene

Gene Ontology (GO) - Biological Process for CST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0010951 negative regulation of endopeptidase activity TAS 3446578
genes like me logo Genes that share ontologies with CST2: view

No data available for SIGNOR curated interactions for CST2 Gene

Drugs & Compounds for CST2 Gene

(1) Drugs for CST2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cysteine Nutra 143

(1) Additional Compounds for CST2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CST2: view

Transcripts for CST2 Gene

mRNA/cDNA for CST2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CST2 Gene

Cystatin SA:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CST2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CST2 Gene

No ASD Table

Relevant External Links for CST2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CST2 Gene

mRNA expression in normal human tissues for CST2 Gene

mRNA differential expression in normal tissues according to GTEx for CST2 Gene

This gene is overexpressed in Adrenal Gland (x16.5), Cervix - Ectocervix (x7.2), Cervix - Endocervix (x5.0), and Prostate (x4.7).

Protein differential expression in normal tissues from HIPED for CST2 Gene

This gene is overexpressed in Skin (41.7), Saliva (13.6), and Salivary gland (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CST2 Gene

SOURCE GeneReport for Unigene cluster for CST2 Gene Hs.669305

mRNA Expression by UniProt/SwissProt for CST2 Gene

Tissue specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in submandibular gland and parotid gland.
genes like me logo Genes that share expression patterns with CST2: view

Protein tissue co-expression partners for CST2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CST2 Gene

Orthologs for CST2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CST2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CST3 36
  • 49 (a)
(Canis familiaris)
Mammalia -- 36
  • 53 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
(Mus musculus)
Mammalia Cst10 36
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
(Pan troglodytes)
Mammalia CST2 36
  • 93 (a)
(Gallus gallus)
Aves gga-mir-3526 36
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
(Danio rerio)
Actinopterygii cst3 36
  • 30 (a)
Species with no ortholog for CST2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CST2 Gene

Gene Tree for CST2 (if available)
Gene Tree for CST2 (if available)

Paralogs for CST2 Gene

Paralogs for CST2 Gene

(10) SIMAP similar genes for CST2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CST2: view

Variants for CST2 Gene

Sequence variations from dbSNP and Humsavar for CST2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs4239738 -- 23,827,967(+) CCTGG(A/T)GTCTC upstream-variant-2KB
rs4365536 -- 23,827,594(+) AATTC(A/G)CTGTG upstream-variant-2KB
rs4378872 -- 23,827,704(+) CTACA(C/T)AGTGT upstream-variant-2KB
rs4407312 -- 23,826,391(+) CAAAC(A/C/T)AGGCT intron-variant
rs4432530 -- 23,827,897(+) GTGGG(A/G)TTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CST2 Gene

Variant ID Type Subtype PubMed ID
dgv698e201 CNV Deletion 23290073
esv2722309 CNV Deletion 23290073
nsv458953 CNV Loss 19166990
dgv783e199 CNV Deletion 23128226
esv2722310 CNV Deletion 23290073
nsv912823 CNV Gain 21882294
nsv436326 CNV Deletion 17901297
nsv3336 CNV Loss 18451855
nsv833944 CNV Gain 17160897

Variation tolerance for CST2 Gene

Residual Variation Intolerance Score: 96.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CST2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CST2 Gene

Disorders for CST2 Gene

Relevant External Links for CST2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CST2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CST2 Gene

Publications for CST2 Gene

  1. Crystal structure of human cystatin C stabilized against amyloid formation. (PMID: 20175878) Kolodziejczyk R. … Jaskolski M. (FEBS J. 2010) 23 67
  2. Beta2-strand of salivary S cystatins: a "chemeleon sequence". (PMID: 19555661) Vitali A. … Petruzzelli R. (Biochem. Biophys. Res. Commun. 2009) 23 67
  3. Relationship between antimicrobial protein levels in whole saliva and periodontitis. (PMID: 18251646) Ito T. … Kato T. (J. Periodontol. 2008) 23 67
  4. Extracellular production of human cystatin S and cystatin SA by Bacillus subtilis. (PMID: 16737825) Akiba S. … Saitoh E. (Protein Expr. Purif. 2006) 23 67
  5. Differences in glomerular filtration rate estimates by 2 cystatin C-based equations. (PMID: 16244309) Risch L. … Huber A.R. (Clin. Chem. 2005) 23 67

Products for CST2 Gene

Sources for CST2 Gene

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