CST11 Gene
protein-coding GIFtS: 44
GCID: GC20M023379
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cystatin 11
(Previous symbol: CST8L)
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Aliases
for CST11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cystatin 111 2 | | SC132 | | CST8L1 2 3 5 | | SC13delta2 | | CTES21 2 | | Cystatin-111 | | DJ322G13.61 | | Cystatin-Related Epididymal-Specific Protein2 |
Export aliases for CST11 gene to outside databasesPrevious GC identifers: GC20M023419 GC20M023426 |
Summaries
for CST11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CST11:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members areactive cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. Thereare three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and thekininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of humanfluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes andpseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein whose specificfunction has not been determined. Alternative splicing yields two variants encoding distinct isoforms. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CST11_HUMAN, Q9H112Function: Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation andfertilization
Gene Wiki entry for CST11
|
Genomic Views
for CST11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CST11 gene promoter:
Max1 TBP Tal-1 AML1a MyoD Arnt GATA-1 E47 STAT3 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for CST11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p11.21 Ensembl cytogenetic band: 20p11.21 HGNC cytogenetic band: 20p11.21CST11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M023379: view genomic region
(about GC identifiers)
Start:
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23,431,040 bp from pter |
End:
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23,433,494 bp from pter |
Size:
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2,455 bases |
Orientation:
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minus strand |
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Proteins
for CST11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CST11_HUMAN, Q9H112 (See
protein sequence)Recommended Name: Cystatin-11 precursor Size: 138 amino acids; 16506 Da
Subcellular location: Nucleus. Cytoplasm. Note=Nuclear and cytoplasmic in the epididymis. Localized to thepostacrosomal and tail regions of sperm. Probably localized to the outer surface of sperm
Secondary accessions: Q0VAF2 Q0VAF3 Q8WXU5 Q8WXU6 Q9H113Alternative splicing: 2 isoforms: Q9H112-1 Q9H112-2 Explore the universe of human proteins at neXtProt for CST11: NX_Q9H112
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H112
CST11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_543020.2 NP_570612.1
ENSEMBL proteins: ENSP00000366208 ENSP00000366206
Human Recombinant Protein Products for CST11:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CST11 for ontologies About GeneDecksing
CST11 Antibody Products:
Assay Products for CST11: |
Protein
Domains /
Families
for CST11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CST11 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H112ProtoNet protein and cluster: Q9H112 2 Blocks protein families: IPB000010 Cysteine protease inhibitor IPB003243 Proteinase inhibitor I25A and I25B
UniProtKB/Swiss-Prot: CST11_HUMAN, Q9H112Similarity: Belongs to the cystatin family |
Function
for CST11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CST11_HUMAN, Q9H112Function: Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation andfertilization Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004869 | cysteine-type endopeptidase inhibitor activity |
IEA | -- |
CST11 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CST11 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CST11 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CST11 (NM_080830) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CST11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST11 |
|
Pathways & Interactions
for CST11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CST11
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042742 | defense response to bacterium |
IEA | -- |
CST11 for ontologies About GeneDecksing
|
Drugs & Compounds
for CST11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CST11
Search CenterWatch for drugs/clinical trials and news about CST11
|
Transcripts
for CST11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CST11 gene (2 alternative transcripts): NM_080830.2 NM_130794.1 Unigene Cluster for CST11: Cystatin 11 Hs.128100 [show with all ESTs]Unigene Representative Sequence: AF3354802 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377009(uc002wtf.1) ENST00000377007(uc002wtg.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CST11 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CST11 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CST11 (NM_080830) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CST11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST11 |
Additional cDNA sequence: AF335480.1 AF335481.1 BC121079.2 BC121080.2 2 DOTS entries: DT.40127248 DT.97831568 8 AceView cDNA sequences: NM_130794 AF335480 NM_080830 AF335481 BX103081 AI200857 AI025187 AA971242
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CST11 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 |
|---|
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| SP1: | | | | | | | | | |
| SP2: | | | | | - | | | |
ECgene alternative splicing isoforms for CST11
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Expression
for CST11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CST11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAGAGAATC
About this image
See CST11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CST11
SOURCE GeneReport for Unigene cluster: Hs.128100
UniProtKB/Swiss-Prot: CST11_HUMAN, Q9H112Tissue specificity: Detected in the epithelium and lumen of the epididymis, and in sperm (at protein level)
SABiosciences Custom PCR Arrays for CST11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CST11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CST11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CST11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST11 |
Orthologs
for CST11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CST11 gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
cst36zgc:1630306 |
zgc:163030 |
23(a)20(a) |
many ↔ manymany ↔ many |
13(33900031-33908388) 13(33894411-33896169) |
ENSEMBL Gene Tree for CST11 (if available)
TreeFam Gene Tree for CST11 (if available) |
Paralogs
for CST11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CST11 gene
- CST42 CST22 CSTL12 CST82 CST72 CST12 CST32 CST52
- CST62
8 SIMAP similar genes for CST11 using alignment to 1 protein entry: CST11_HUMAN:CST8 CST2 CST4 CSTL1 CST1 CST5
CST3 CST9L
CST11 for paralogs About GeneDecksing
|
Genomic Variants
for CST11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CST11 (23431040 - 23433494 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CST11: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CST11 |
|
Disorders
/ Diseases
for CST11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CST11 for disorders About GeneDecksing
OMIM gene information: 609731
OMIM disorders: --
3  diseases for CST11: About MalaCardsepididymitis cerebral hemorrhage cerebritis
Export disorders for CST11 gene to outside databases
|
Publications
for CST11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CST11 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with CST11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evolution and human tissue expression of the Cres/Tes tatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cys tatins. (PubMed id 20565543)1, 3 Frygelius J....TAPhAPnen V. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cystatin 11: a new member of the cystatin type 2 family. (PubMed id 12072414)1, 2 Hamil K.G.... Hall S.H. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Reactivation of p53 function in synovial sarcoma cells by inhibition of p53-HDM2 interaction. (PubMed id 19081178)1 D'Arcy P....Brodin B. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Friends and relations of the cystatin superfamily--new members and their evolution. (PubMed id 9007972)1 Brown W.M. and Dziegielewska K.M. (1997)
- The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20. (PubMed id 8179826)1 Thiesse M....Dickinson D.P. (1994)
- Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2. (PubMed id 7896273)1 Dickinson D.P....Siciliano M.J. (1994)
- Genomic cloning, physical mapping, and expression of human type 2 cystatin genes. (PubMed id 7690606)1 Dickinson D.P....Millar S.J. (1993)
|
External Searches for CST11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CST11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CST11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CST11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CST11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CST11 gene:
Search GeneIP for patents involving CST11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CST11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CST11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CST11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CST11 | | | OriGene Protein Over-expression Lysate for CST11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CST11 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CST11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CST11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CST11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CST11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CST11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CST11 |
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| | | | Search Tocris compounds for CST11 |
| |  |  |  |  | | | | |
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 | | | CST11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST11 |
|  |  |  |  | | | | ThermoFisher Antibodies for CST11 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST11 |
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