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Aliases for CST11 Gene

Aliases for CST11 Gene

  • Cystatin 11 2 3
  • CST8L 3 4 6
  • Cystatin-Related Epididymal-Specific Protein 3
  • Cystatin-11 3
  • DJ322G13.6 3
  • SC13delta 3
  • CTES2 3
  • SC13 3

External Ids for CST11 Gene

Previous HGNC Symbols for CST11 Gene

  • CST8L

Previous GeneCards Identifiers for CST11 Gene

  • GC20M023419
  • GC20M023426
  • GC20M023379

Summaries for CST11 Gene

Entrez Gene Summary for CST11 Gene

  • The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014]

GeneCards Summary for CST11 Gene

CST11 (Cystatin 11) is a Protein Coding gene. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST2.

UniProtKB/Swiss-Prot for CST11 Gene

  • Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.

Gene Wiki entry for CST11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CST11 Gene

Genomics for CST11 Gene

Regulatory Elements for CST11 Gene

Genomic Location for CST11 Gene

Start:
23,450,403 bp from pter
End:
23,452,857 bp from pter
Size:
2,455 bases
Orientation:
Minus strand

Genomic View for CST11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CST11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CST11 Gene

Proteins for CST11 Gene

  • Protein details for CST11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H112-CST11_HUMAN
    Recommended name:
    Cystatin-11
    Protein Accession:
    Q9H112
    Secondary Accessions:
    • Q0VAF2
    • Q0VAF3
    • Q8WXU5
    • Q8WXU6
    • Q9H113

    Protein attributes for CST11 Gene

    Size:
    138 amino acids
    Molecular mass:
    16506 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CST11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CST11 Gene

Proteomics data for CST11 Gene at MOPED

Post-translational modifications for CST11 Gene

  • Glycosylation at Asn132
  • Modification sites at PhosphoSitePlus

Other Protein References for CST11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CST11 Gene

Domains for CST11 Gene

Suggested Antigen Peptide Sequences for CST11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H112

UniProtKB/Swiss-Prot:

CST11_HUMAN :
  • Q9H112
Family:
  • Belongs to the cystatin family.
genes like me logo Genes that share domains with CST11: view

No data available for Gene Families for CST11 Gene

Function for CST11 Gene

Molecular function for CST11 Gene

UniProtKB/Swiss-Prot Function: Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.

Gene Ontology (GO) - Molecular Function for CST11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with CST11: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CST11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CST11 Gene

Localization for CST11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CST11 Gene

Nucleus. Cytoplasm. Note=Nuclear and cytoplasmic in the epididymis. Localized to the postacrosomal and tail regions of sperm. Probably localized to the outer surface of sperm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CST11 Gene COMPARTMENTS Subcellular localization image for CST11 gene
Compartment Confidence
nucleus 5
extracellular 3

Gene Ontology (GO) - Cellular Components for CST11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CST11: view

Pathways for CST11 Gene

SuperPathways for CST11 Gene

No Data Available

Interacting Proteins for CST11 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366208%0d%0a9606.ENSP00000414516%0d%0a
Selected Interacting proteins: ENSP00000366208 for CST11 Gene via STRING

Symbol External ID(s) Details
SS18

Gene Ontology (GO) - Biological Process for CST11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with CST11: view

No data available for Pathways by source for CST11 Gene

Transcripts for CST11 Gene

mRNA/cDNA for CST11 Gene

(8) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CST11 Gene

Cystatin 11:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CST11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CST11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CST11 Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2: -

Relevant External Links for CST11 Gene

GeneLoc Exon Structure for
CST11
ECgene alternative splicing isoforms for
CST11

Expression for CST11 Gene

mRNA expression in normal human tissues for CST11 Gene

mRNA differential expression in normal tissues according to GTEx for CST11 Gene

This gene is overexpressed in Stomach (13.0), Testis (9.4), Colon - Sigmoid (5.5), and Bladder (4.8).

SOURCE GeneReport for Unigene cluster for CST11 Gene Hs.128100

mRNA Expression by UniProt/SwissProt for CST11 Gene

Q9H112-CST11_HUMAN
Tissue specificity: Detected in the epithelium and lumen of the epididymis, and in sperm (at protein level).
genes like me logo Genes that share expressions with CST11: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for CST11 Gene

Orthologs for CST11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CST11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CST11 35
  • 98.07 (n)
  • 96.38 (a)
CST11 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CST11 35
  • 66.42 (n)
  • 49.64 (a)
CST11 36
  • 49 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CST11 35
  • 74.45 (n)
  • 62.04 (a)
CST11 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cst11 35
  • 71.57 (n)
  • 54.41 (a)
Cst11 16
Cst11 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cst11 35
  • 69.32 (n)
  • 50 (a)
chicken
(Gallus gallus)
Aves gga-mir-3526 36
  • 25 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 24 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:163030 36
  • 23 (a)
ManyToMany
Species with no ortholog for CST11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CST11 Gene

ENSEMBL:
Gene Tree for CST11 (if available)
TreeFam:
Gene Tree for CST11 (if available)

Paralogs for CST11 Gene

Paralogs for CST11 Gene

Selected SIMAP similar genes for CST11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CST11: view

Variants for CST11 Gene

Sequence variations from dbSNP and Humsavar for CST11 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1055183 -- 23,450,494(-) TGGAG(G/T)GTACA utr-variant-3-prime
rs2064587 -- 23,452,965(+) GCAGC(C/T)GAACT upstream-variant-2KB
rs2073271 -- 23,452,910(-) CACCA(A/G/T)CTGCT upstream-variant-2KB
rs2236021 -- 23,451,891(-) CTGAA(C/T)GTGGA intron-variant, synonymous-codon, reference
rs2249239 -- 23,452,254(-) AGTTA(C/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CST11 Gene

Variant ID Type Subtype PubMed ID
dgv4559n71 CNV Gain 21882294
nsv912820 CNV Gain+Loss 21882294
nsv470544 CNV Gain 18288195
nsv458949 CNV Gain 19166990

Relevant External Links for CST11 Gene

HapMap Linkage Disequilibrium report
CST11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CST11 Gene

Disorders for CST11 Gene

No disorders were found for CST11 Gene.

No data available for UniProtKB/Swiss-Prot for CST11 Gene

Publications for CST11 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  2. Cystatin 11: a new member of the cystatin type 2 family. (PMID: 12072414) Hamil K.G. … Hall S.H. (Endocrinology 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Evolution and human tissue expression of the Cres/Testatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cystatins. (PMID: 20565543) Frygelius J. … TAPhAPnen V. (Evol. Dev. 2010) 2 3
  5. Reactivation of p53 function in synovial sarcoma cells by inhibition of p53-HDM2 interaction. (PMID: 19081178) D'Arcy P. … Brodin B. (Cancer Lett. 2009) 3

Products for CST11 Gene

Sources for CST11 Gene

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