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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CST11 Gene

protein-coding   GIFtS: 46
GCID: GC20M023379

Cystatin 11


(Previous symbol: CST8L)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cystatin 111 2     SC13delta2
CST8L1 2 3 5     cystatin-112
CTES22     Cystatin-Related Epididymal-Specific Protein2
SC132     dJ322G13.62

External Ids:    HGNC: 159591   Entrez Gene: 1408802   Ensembl: ENSG000001258317   OMIM: 6097315   UniProtKB: Q9H1123   

Export aliases for CST11 gene to outside databases

Previous GC identifers: GC20M023419 GC20M023426


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CST11 Gene:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members
are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory
activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type
2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found
in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the
type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an
epididymal-specific protein whose specific function has not been determined. Alternative splicing yields two
variants encoding distinct isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for CST11 Gene: 
CST11 (cystatin 11) is a protein-coding gene. Diseases associated with CST11 include epididymitis, and cerebral hemorrhage. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST4.

UniProtKB/Swiss-Prot: CST11_HUMAN, Q9H112
Function: Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm
maturation and fertilization

Gene Wiki entry for CST11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CST11 gene promoter:
         Max1   TBP   Tal-1   AML1a   MyoD   Arnt   GATA-1   E47   STAT3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCST11 promoter sequence
   Search SABiosciences Chromatin IP Primers for CST11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CST11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.21   Ensembl cytogenetic band:  20p11.21   HGNC cytogenetic band: 20p11.21

CST11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CST11 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M023379:  view genomic region     (about GC identifiers)

Start:
23,431,040 bp from pter      End:
23,433,494 bp from pter
Size:
2,455 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CST11_HUMAN, Q9H112 (See protein sequence)
Recommended Name: Cystatin-11 precursor  
Size: 138 amino acids; 16506 Da
Subcellular location: Nucleus. Cytoplasm. Note=Nuclear and cytoplasmic in the epididymis. Localized to the
postacrosomal and tail regions of sperm. Probably localized to the outer surface of sperm
Secondary accessions: Q0VAF2 Q0VAF3 Q8WXU5 Q8WXU6 Q9H113
Alternative splicing: 2 isoforms:  Q9H112-1   Q9H112-2   

Explore the universe of human proteins at neXtProt for CST11: NX_Q9H112

Explore proteomics data for CST11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H112

  • CST11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CST11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_543020.2  NP_570612.1  

    ENSEMBL proteins: 
     ENSP00000366208   ENSP00000366206  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    CST11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000010 Prot_inh_cystat
     IPR027214 Cystatin

    Graphical View of Domain Structure for InterPro Entry Q9H112

    ProtoNet protein and cluster: Q9H112

    2 Blocks protein domains:
    IPB000010 Cysteine protease inhibitor
    IPB003243 Proteinase inhibitor I25A and I25B


    UniProtKB/Swiss-Prot: CST11_HUMAN, Q9H112
    Similarity: Belongs to the cystatin family


    CST11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CST11_HUMAN, Q9H112
    Function: Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm
    maturation and fertilization

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004869cysteine-type endopeptidase inhibitor activity IEA--
         
    CST11 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CST11 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CST11 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CST11

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042742defense response to bacterium IEA--

    CST11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CST11

    Search CenterWatch for drugs/clinical trials and news about CST11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CST11 gene (2 alternative transcripts): 
    NM_080830.2  NM_130794.1  

    Unigene Cluster for CST11:

    Cystatin 11
    Hs.128100  [show with all ESTs]
    Unigene Representative Sequence: AF335480
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377009(uc002wtf.1) ENST00000377007(uc002wtg.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CST11
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CST11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CST11
    Clone
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    OriGene ORF clones in mouse, rat for CST11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CST11 (NM_080830)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CST11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CST11
    Sirion Biotech Customized lentivirus for stable overexpression of CST11 
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CST11
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CST11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST11

    Additional mRNA sequence: 

    AF335480.1 AF335481.1 BC121079.2 BC121080.2 

    2 DOTS entries:

    DT.40127248  DT.97831568 

    8 AceView cDNA sequences:

    AF335480 NM_080830 NM_130794 AI200857 BX103081 AF335481 AI025187 AA971242 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CST11    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3
    SP1:                        
    SP2:              -         


    ECgene alternative splicing isoforms for CST11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CST11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGAGAATC
    CST11 Expression
    About this image


    See CST11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CST11

    SOURCE GeneReport for Unigene cluster: Hs.128100

    UniProtKB/Swiss-Prot: CST11_HUMAN, Q9H112
    Tissue specificity: Detected in the epithelium and lumen of the epididymis, and in sperm (at protein level)

        SABiosciences Custom PCR Arrays for CST11
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CST11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CST11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CST11 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cst111 , 5 cystatin 111, 5 71.57(n)1
    54.41(a)1
      2 (73.54 cM)5
    782401  NM_030059.21  NP_084335.11 
     1487686095 
    zebrafish
    (Danio rerio)
    Actinopterygii cst36
    zgc:1630306
    zgc:163030
    23(a)
    22(a)
    many ↔ many
    many ↔ many
    13(33900031-33908388)
    13(33894411-33896169)


    ENSEMBL Gene Tree for CST11 (if available)
    TreeFam Gene Tree for CST11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CST11 gene
    CST42  CST22  CSTL12  CST82  CST12  CST32  CST52  
    8 SIMAP similar genes for CST11 using alignment to 1 protein entry:     CST11_HUMAN:
    CST8    CST2    CST4    CSTL1    CST1    CST5
    CST3    CST9L

    CST11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/138 SNPs in CST11 are shown (see all 138)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1412546781,2
    --23430558(+) GAAGTC/TTAATT 2 -- ds50010--------
    rs1886108851,2
    --23430641(+) GTAGCA/CAAGGC 2 -- ds50010--------
    rs1922771531,2
    C--23430645(+) CAAAGA/GCCTTG 2 -- ds50010--------
    rs1843369121,2
    --23430704(+) GGAGAC/GAGGGT 2 -- ds50010--------
    rs116961161,2
    H--23430730(+) CCTCAC/GACGTG 2 -- ds50010--------
    rs1469750291,2
    --23430733(+) CAGACA/GTGCCA 2 -- ds50010--------
    rs1151440701,2
    F--23430994(+) GAGCTG/AAAGAA 2 -- ds50011Minor allele frequency- A:0.01WA 118
    rs22732371,2
    C,F--23431011(-) TTTTCT/CTTTTA 2 -- ds50016Minor allele frequency- C:0.19WA NA CSA EA 364
    rs1999617151,2
    C--23431121(+) TGGCCA/GCAGTT 2 -- ut310--------
    rs10551831,2
    C--23431131(-) TGGAGT/GGTACA 2 -- ut312Minor allele frequency- G:0.00NA 4

    HapMap Linkage Disequilibrium report for CST11 (23431040 - 23433494 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CST11:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv458949CNV Gain19166990
    dgv4559n71CNV Gain21882294
    nsv470544CNV Gain18288195
    nsv912820CNV Gain+Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609731    OMIM disorders: --

    5 diseases for CST11:    About MalaCards
    epididymitis    cerebral hemorrhage    synovial sarcoma    cerebritis
    sarcoma


    CST11 for disorders           About GeneDecksing


    Export disorders for CST11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CST11 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with CST11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolution and human tissue expression of the Cres/Tes tatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cys tatins. (PubMed id 20565543)1, 3 Frygelius J....TAPhAPnen V. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Cystatin 11: a new member of the cystatin type 2 family. (PubMed id 12072414)1, 2 Hamil K.G.... Hall S.H. (2002)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. Reactivation of p53 function in synovial sarcoma cells by inhibition of p53-HDM2 interaction. (PubMed id 19081178)1 D'Arcy P....Brodin B. (2009)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Friends and relations of the cystatin superfamily--new members and their evolution. (PubMed id 9007972)1 Brown W.M. and Dziegielewska K.M. (1997)
    8. The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20. (PubMed id 8179826)1 Thiesse M....Dickinson D.P. (1994)
    9. Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2. (PubMed id 7896273)1 Dickinson D.P....Siciliano M.J. (1994)
    10. Genomic cloning, physical mapping, and expression of human type 2 cystatin genes. (PubMed id 7690606)1 Dickinson D.P....Millar S.J. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140880 HGNC: 15959 AceView: CST11 Ensembl:ENSG00000125831 euGenes: HUgn140880
    ECgene: CST11 H-InvDB: CST11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CST11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CST11 gene:
    Search GeneIP for patents involving CST11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CST11
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     Regulatory tfbs in CST11 promoter
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     Browse Sino Biological Proteins and Antibodies
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     Proteins for CST11
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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