Aliases for CST11 Gene
External Ids for CST11 Gene
Previous HGNC Symbols for CST11 Gene
Previous GeneCards Identifiers for CST11 Gene
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014]
GeneCards Summary for CST11 Gene
CST11 (Cystatin 11) is a Protein Coding gene. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST8.
UniProtKB/Swiss-Prot for CST11 Gene
Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.