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Aliases for CST1 Gene

Aliases for CST1 Gene

  • Cystatin SN 2 3
  • Salivary Cystatin-SA-1 3 4
  • Cystain-SA-I 3 4
  • Cystatin-1 3 4
  • Cysteine Proteinase Inhibitor, Type 2 Family 3
  • Cystatin SA-I 3
  • Cystatin-SN 3
  • Cystatin 1 3

External Ids for CST1 Gene

Previous GeneCards Identifiers for CST1 Gene

  • GC20M023716
  • GC20M023676
  • GC20M023723
  • GC20M023687

Summaries for CST1 Gene

Entrez Gene Summary for CST1 Gene

  • The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. [provided by RefSeq, Jul 2008]

GeneCards Summary for CST1 Gene

CST1 (Cystatin SN) is a Protein Coding gene. Diseases associated with CST1 include denture stomatitis and stomatitis. Among its related pathways are Salivary secretion. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST2.

UniProtKB/Swiss-Prot for CST1 Gene

  • Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well

Gene Wiki entry for CST1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CST1 Gene

Genomics for CST1 Gene

Regulatory Elements for CST1 Gene

Genomic Location for CST1 Gene

Start:
23,747,553 bp from pter
End:
23,751,268 bp from pter
Size:
3,716 bases
Orientation:
Minus strand

Genomic View for CST1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CST1 Gene

Proteins for CST1 Gene

  • Protein details for CST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01037-CYTN_HUMAN
    Recommended name:
    Cystatin-SN
    Protein Accession:
    P01037
    Secondary Accessions:
    • Q96LE6
    • Q9UCQ6

    Protein attributes for CST1 Gene

    Size:
    141 amino acids
    Molecular mass:
    16388 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CST1 Gene

Proteomics data for CST1 Gene at MOPED

Post-translational modifications for CST1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CST1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CST1 Gene

Domains for CST1 Gene

Suggested Antigen Peptide Sequences for CST1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01037

UniProtKB/Swiss-Prot:

CYTN_HUMAN :
  • P01037
Family:
  • Belongs to the cystatin family.
genes like me logo Genes that share domains with CST1: view

No data available for Gene Families for CST1 Gene

Function for CST1 Gene

Molecular function for CST1 Gene

GENATLAS Biochemistry: cystatin SN,cysteine proteinase inhibitor,type 2 family
UniProtKB/Swiss-Prot Function: Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well

Gene Ontology (GO) - Molecular Function for CST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CST1: view

Phenotypes for CST1 Gene

GenomeRNAi human phenotypes for CST1:
genes like me logo Genes that share phenotypes with CST1: view

Animal Model Products

miRNA for CST1 Gene

miRTarBase miRNAs that target CST1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CST1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CST1 Gene

Localization for CST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CST1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CST1 Gene COMPARTMENTS Subcellular localization image for CST1 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for CST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
genes like me logo Genes that share ontologies with CST1: view

Pathways for CST1 Gene

SuperPathways for CST1 Gene

Superpath Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with CST1: view

Pathways by source for CST1 Gene

1 KEGG pathway for CST1 Gene

Interacting Proteins for CST1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000305731%0d%0a9606.ENSP00000356022%0d%0a9606.ENSP00000221566%0d%0a
Selected Interacting proteins: ENSP00000305731 P01037-CYTN_HUMAN for CST1 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for CST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0010951 negative regulation of endopeptidase activity TAS 3446578
genes like me logo Genes that share ontologies with CST1: view

Compounds for CST1 Gene

(3) Novoseek inferred chemical compound relationships for CST1 Gene

Compound -log(P) Hits PubMed IDs
kininogen 63.9 2
cysteine 62.1 12
iptg 45.6 1
genes like me logo Genes that share compounds with CST1: view

Transcripts for CST1 Gene

mRNA/cDNA for CST1 Gene

(198) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CST1 Gene

Cystatin SN:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CST1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CST1 Gene

No ASD Table

Relevant External Links for CST1 Gene

GeneLoc Exon Structure for
CST1
ECgene alternative splicing isoforms for
CST1

Expression for CST1 Gene

mRNA expression in normal human tissues for CST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CST1 Gene

This gene is overexpressed in Prostate (19.2), Nerve - Tibial (18.1), and Skin - Not Sun Exposed (Suprapubic) (5.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CST1 Gene

SOURCE GeneReport for Unigene cluster for CST1 Gene Hs.123114

mRNA Expression by UniProt/SwissProt for CST1 Gene

P01037-CYTN_HUMAN
Tissue specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid.
genes like me logo Genes that share expressions with CST1: view

In Situ Assay Products

Orthologs for CST1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CST1 35
  • 97.4 (n)
  • 95.04 (a)
CST1 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CST3 36
  • 52 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 54 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cst10 36
  • 39 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 42 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-3526 36
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cst3 36
  • 32 (a)
ManyToMany
Species with no ortholog for CST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CST1 Gene

ENSEMBL:
Gene Tree for CST1 (if available)
TreeFam:
Gene Tree for CST1 (if available)

Paralogs for CST1 Gene

Paralogs for CST1 Gene

Selected SIMAP similar genes for CST1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CST1: view

Variants for CST1 Gene

Sequence variations from dbSNP and Humsavar for CST1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2982 -- 23,747,705(-) GCCTG(C/T)GCCAA utr-variant-3-prime
rs1048314 -- 23,747,596(-) CACAC(A/C)CCCCC utr-variant-3-prime
rs1141013 -- 23,750,875(-) CCTCT(A/G)AGGAG utr-variant-5-prime
rs2070855 -- 23,751,028(-) ATGGG(A/C)AGAAA upstream-variant-2KB
rs2070856 - 23,750,775(-) AATCC(C/T)GGGTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CST1 Gene

Variant ID Type Subtype PubMed ID
esv2722303 CNV Deletion 23290073
nsv458952 CNV Gain 19166990
nsv912821 CNV Gain+Loss 21882294
dgv697e201 CNV Deletion 23290073
nsv518208 CNV Gain 19592680
dgv698e201 CNV Deletion 23290073
esv2722309 CNV Deletion 23290073
esv33509 CNV Gain 17666407
esv2667835 CNV Deletion 23128226
nsv912822 CNV Loss 21882294
nsv458953 CNV Loss 19166990
nsv515880 CNV Loss 19592680

Relevant External Links for CST1 Gene

HapMap Linkage Disequilibrium report
CST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CST1 Gene

Disorders for CST1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CST1 Gene including...

Search for CST1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CST1 Gene

(1) Novoseek inferred disease relationships for CST1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 0 1

Relevant External Links for CST1

Genetic Association Database (GAD)
CST1
Human Genome Epidemiology (HuGE) Navigator
CST1
genes like me logo Genes that share disorders with CST1: view

No data available for UniProtKB/Swiss-Prot for CST1 Gene

Publications for CST1 Gene

  1. Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S. (PMID: 1778989) Isemura S. … Minakata K. (J. Biochem. 1991) 3 4 23
  2. Human salivary cystatin S. Cloning, sequence analysis, hybridization in situ and immunocytochemistry. (PMID: 1898352) Bobek L.A. … Levine M.J. (Biochem. J. 1991) 3 23
  3. Upregulation of the cysteine protease inhibitor, cystatin SN, contributes to cell proliferation and cathepsin inhibition in gastric cancer. (PMID: 19463800) Choi E.H. … Lee H.G. (Clin. Chim. Acta 2009) 3 23
  4. Identification of Cystatin SN as a novel tumor marker for colorectal cancer. (PMID: 19513549) Yoneda K. … Nakajima A. (Int. J. Oncol. 2009) 3 23
  5. Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry. (PMID: 20189825) Ryan C.M. … Whitelegge J.P. (J. Am. Soc. Mass Spectrom. 2010) 4 23

Products for CST1 Gene

Sources for CST1 Gene

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