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Aliases for CSRP3 Gene

Aliases for CSRP3 Gene

  • Cysteine And Glycine Rich Protein 3 2 3 5
  • Cardiac LIM Protein 2 4
  • CRP3 3 4
  • CLP 3 4
  • MLP 3 4
  • Cysteine And Glycine-Rich Protein 3 (Cardiac LIM Protein) 3
  • LIM Domain Protein, Cardiac 4
  • Cardiac LIM Domain Protein 3
  • Muscle Lim Protein Isoform 3
  • Cysteine-Rich Protein 3 4
  • Muscle LIM Protein 4
  • LIM Domain Only 4 3
  • CMD1M 3
  • CMH12 3
  • LMO4 3

External Ids for CSRP3 Gene

Previous GeneCards Identifiers for CSRP3 Gene

  • GC11M020365
  • GC11M020147
  • GC11M019243
  • GC11M019168
  • GC11M018887

Summaries for CSRP3 Gene

Entrez Gene Summary for CSRP3 Gene

  • This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSRP3 Gene

CSRP3 (Cysteine And Glycine Rich Protein 3) is a Protein Coding gene. Diseases associated with CSRP3 include cardiomyopathy, hypertrophic, 12 and cardiomyopathy, dilated, 1m. Among its related pathways are IL6-mediated signaling events and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include structural constituent of muscle and telethonin binding. An important paralog of this gene is CRIP2.

UniProtKB/Swiss-Prot for CSRP3 Gene

  • Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity).

Gene Wiki entry for CSRP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRP3 Gene

Genomics for CSRP3 Gene

Regulatory Elements for CSRP3 Gene

Genomic Location for CSRP3 Gene

Chromosome:
11
Start:
19,182,030 bp from pter
End:
19,210,573 bp from pter
Size:
28,544 bases
Orientation:
Minus strand

Genomic View for CSRP3 Gene

Genes around CSRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRP3 Gene

Proteins for CSRP3 Gene

  • Protein details for CSRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50461-CSRP3_HUMAN
    Recommended name:
    Cysteine and glycine-rich protein 3
    Protein Accession:
    P50461
    Secondary Accessions:
    • Q9P131

    Protein attributes for CSRP3 Gene

    Size:
    194 amino acids
    Molecular mass:
    20969 Da
    Quaternary structure:
    • Interacts with LDHD. Interacts with GLRX3 (via C-terminus).

    Three dimensional structures from OCA and Proteopedia for CSRP3 Gene

neXtProt entry for CSRP3 Gene

Proteomics data for CSRP3 Gene at MOPED

Post-translational modifications for CSRP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSRP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CSRP3 Gene

Domains & Families for CSRP3 Gene

Gene Families for CSRP3 Gene

Protein Domains for CSRP3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CSRP3 Gene

Graphical View of Domain Structure for InterPro Entry

P50461

UniProtKB/Swiss-Prot:

CSRP3_HUMAN :
  • Contains 2 LIM zinc-binding domains.
Domain:
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with CSRP3: view

Function for CSRP3 Gene

Molecular function for CSRP3 Gene

GENATLAS Biochemistry:
Lim only domain protein,cysteine and glycine rich,expressed in cardiac and skeletal muscles,likely involved in the determination of cell lineage and regulation of cell differentiation
UniProtKB/Swiss-Prot Function:
Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity).

Gene Ontology (GO) - Molecular Function for CSRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031433 telethonin binding IPI 15582318
genes like me logo Genes that share ontologies with CSRP3: view
genes like me logo Genes that share phenotypes with CSRP3: view

Human Phenotype Ontology for CSRP3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CSRP3 Gene

MGI Knock Outs for CSRP3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CSRP3 Gene

Localization for CSRP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRP3 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Mainly cytoplasmic (By similarity). In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3 (By similarity). {ECO:0000250, ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSRP3 Gene COMPARTMENTS Subcellular localization image for CSRP3 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for CSRP3 Gene

Pathways & Interactions for CSRP3 Gene

genes like me logo Genes that share pathways with CSRP3: view

Pathways by source for CSRP3 Gene

Gene Ontology (GO) - Biological Process for CSRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling IEA --
GO:0007519 skeletal muscle tissue development TAS 7954791
GO:0033365 protein localization to organelle IMP 12507422
GO:0045662 negative regulation of myoblast differentiation IDA 24860983
GO:0045663 positive regulation of myoblast differentiation IDA 24860983
genes like me logo Genes that share ontologies with CSRP3: view

No data available for SIGNOR curated interactions for CSRP3 Gene

Drugs & Compounds for CSRP3 Gene

No Compound Related Data Available

Transcripts for CSRP3 Gene

mRNA/cDNA for CSRP3 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(131) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSRP3 Gene

Cysteine and glycine-rich protein 3 (cardiac LIM protein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSRP3 Gene

No ASD Table

Relevant External Links for CSRP3 Gene

GeneLoc Exon Structure for
CSRP3
ECgene alternative splicing isoforms for
CSRP3

Expression for CSRP3 Gene

mRNA expression in normal human tissues for CSRP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSRP3 Gene

This gene is overexpressed in Heart - Left Ventricle (x28.5), Heart - Atrial Appendage (x13.9), and Muscle - Skeletal (x9.2).

Protein differential expression in normal tissues from HIPED for CSRP3 Gene

This gene is overexpressed in Heart (34.2) and Fetal heart (27.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSRP3 Gene



SOURCE GeneReport for Unigene cluster for CSRP3 Gene Hs.83577

mRNA Expression by UniProt/SwissProt for CSRP3 Gene

P50461-CSRP3_HUMAN
Tissue specificity: Cardiac and slow-twitch skeletal muscles.
genes like me logo Genes that share expression patterns with CSRP3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CSRP3 Gene

Orthologs for CSRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSRP3 36
  • 99 (a)
OneToOne
CSRP3 35
  • 99.83 (n)
  • 99.48 (a)
cow
(Bos Taurus)
Mammalia CSRP3 35
  • 90.5 (n)
  • 97.93 (a)
CSRP3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSRP3 36
  • 99 (a)
OneToOne
CSRP3 35
  • 91.07 (n)
  • 99.48 (a)
mouse
(Mus musculus)
Mammalia Csrp3 16
Csrp3 35
  • 91.24 (n)
  • 97.94 (a)
Csrp3 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSRP3 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-7434 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csrp3 35
  • 89.86 (n)
  • 95.88 (a)
chicken
(Gallus gallus)
Aves CSRP3 35
  • 79.27 (n)
  • 89.12 (a)
CSRP3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSRP3 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia csrp3-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia csrp3 35
  • 75.35 (n)
  • 81.77 (a)
zebrafish
(Danio rerio)
Actinopterygii csrp3 36
  • 74 (a)
OneToOne
csrp3 35
  • 68.67 (n)
  • 75.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mlp84B 37
  • 46 (a)
Mlp60A 35
  • 55.89 (n)
  • 53.29 (a)
Mlp60A 36
  • 20 (a)
ManyToMany
Mlp84B 36
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea mlp-1 36
  • 50 (a)
OneToMany
Species with no ortholog for CSRP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRP3 Gene

ENSEMBL:
Gene Tree for CSRP3 (if available)
TreeFam:
Gene Tree for CSRP3 (if available)

Paralogs for CSRP3 Gene

Paralogs for CSRP3 Gene

(5) SIMAP similar genes for CSRP3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CSRP3: view

Variants for CSRP3 Gene

Sequence variations from dbSNP and Humsavar for CSRP3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs746207 -- 19,188,188(-) AAGGC(A/G/T)CTGGC reference, missense
rs721067 -- 19,191,179(-) CACTG(A/T)GATTT intron-variant
rs793279 -- 19,209,693(-) gagaa(C/G)aagtg intron-variant
rs1077687 -- 19,187,026(-) GTCAC(A/G)CTCTG intron-variant
rs1077688 -- 19,186,523(+) GGCGA(A/C)ATTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSRP3 Gene

Variant ID Type Subtype PubMed ID
esv2744177 CNV Deletion 23290073

Variation tolerance for CSRP3 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSRP3 Gene

HapMap Linkage Disequilibrium report
CSRP3
Human Gene Mutation Database (HGMD)
CSRP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSRP3 Gene

Disorders for CSRP3 Gene

MalaCards: The human disease database

(14) MalaCards diseases for CSRP3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cardiomyopathy, hypertrophic, 12
  • cardiomyopathy, familial hypertrophic, 12
cardiomyopathy, dilated, 1m
  • cmd1m
csrp3-related dilated cardiomyopathy
  • cardiomyopathy, dilated, 1m
csrp3-related familial hypertrophic cardiomyopathy
familial isolated dilated cardiomyopathy
  • familial or idiopathic dilated cardiomyopathy
- elite association - COSMIC cancer census association via MalaCards
Search CSRP3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CSRP3_HUMAN
  • Cardiomyopathy, dilated 1M (CMD1M) [MIM:607482]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269 PubMed:12507422}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Cardiomyopathy, familial hypertrophic 12 (CMH12) [MIM:612124]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269 PubMed:12642359, ECO:0000269 PubMed:18505755}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CSRP3

Genetic Association Database (GAD)
CSRP3
Human Genome Epidemiology (HuGE) Navigator
CSRP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSRP3
genes like me logo Genes that share disorders with CSRP3: view

No data available for Genatlas for CSRP3 Gene

Publications for CSRP3 Gene

  1. Mapping of a human LIM protein (CLP) to human chromosome 11p15.1 by fluorescence in situ hybridization. (PMID: 7490106) Fung Y.W. … Liew C.C. (Genomics 1995) 2 3 4 67
  2. A common MLP (muscle LIM protein) variant is associated with cardiomyopathy. (PMID: 20044516) KnAPll R. … Chien K.R. (Circ. Res. 2010) 3 23
  3. Structure and dynamics of the human muscle LIM protein. (PMID: 19230835) Schallus T. … Muhle-Goll C. (FEBS Lett. 2009) 3 23
  4. The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy. (PMID: 19293840) MA … ber L. (Eur. J. Hum. Genet. 2009) 3 23
  5. Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle. (PMID: 19752190) Papalouka V. … Sanoudou D. (Mol. Cell. Biol. 2009) 3 23

Products for CSRP3 Gene

Sources for CSRP3 Gene

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