Aliases for CSRP3 Gene
External Ids for CSRP3 Gene
Previous GeneCards Identifiers for CSRP3 Gene
This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CSRP3 Gene
CSRP3 (Cysteine And Glycine Rich Protein 3) is a Protein Coding gene. Diseases associated with CSRP3 include cardiomyopathy, hypertrophic, 12 and cardiomyopathy, dilated, 1m. Among its related pathways are IL6-mediated signaling events and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include structural constituent of muscle and telethonin binding. An important paralog of this gene is CRIP2.
UniProtKB/Swiss-Prot for CSRP3 Gene
Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity).