Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CSRP3 Gene

protein-coding   GIFtS: 60
GCID: GC11M019160

Cysteine And Glycine-Rich Protein 3 (Cardiac LIM Protein)

  See CSRP3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cysteine And Glycine-Rich Protein 3 (Cardiac LIM Protein)1 2     Cysteine And Glycine-Rich Protein 32
CLP2 3 5     LIM Domain Only 42
CRP32 3 5     Muscle Lim Protein Isoform2
MLP2 3     Cardiac LIM Protein3
CMD1M2 5     Cysteine-Rich Protein 33
CMH122 5     LIM Domain Protein, Cardiac3
LMO42     Muscle LIM Protein3
Cardiac LIM Domain Protein2     

External Ids:    HGNC: 24721   Entrez Gene: 80482   Ensembl: ENSG000001291707   OMIM: 6008245   UniProtKB: P504613   

Export aliases for CSRP3 gene to outside databases

Previous GC identifers: GC11M020365 GC11M020147 GC11M019243 GC11M019168 GC11M018887


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CSRP3 Gene:
This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory
processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this
protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic
differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM)
and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but
encoding the same protein, have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CSRP3 Gene:
CSRP3 (cysteine and glycine-rich protein 3 (cardiac LIM protein)) is a protein-coding gene. Diseases associated with CSRP3 include cardiomyopathy, dilated, 1m, and cardiomyopathy, familial hypertrophic, 12. GO annotations related to this gene include structural constituent of muscle and telethonin binding. An important paralog of this gene is CSRP2.

UniProtKB/Swiss-Prot: CSRP3_HUMAN, P50461
Function: Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic
structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that
promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to
the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity)

Gene Wiki entry for CSRP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSRP3 gene promoter:
         RORalpha1   NF-1   Sox9   Hlf   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSRP3 promoter sequence
   Search Chromatin IP Primers for CSRP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSRP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

CSRP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSRP3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M019160:  view genomic region     (about GC identifiers)

Start:
19,203,578 bp from pter      End:
19,232,120 bp from pter
Size:
28,543 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CSRP3_HUMAN, P50461 (See protein sequence)
Recommended Name: Cysteine and glycine-rich protein 3  
Size: 194 amino acids; 20969 Da
Subunit: Interacts with LDHD (By similarity). Interacts with GLRX3 (via C-terminus) (By similarity)
2 PDB 3D structures from and Proteopedia for CSRP3:
2O10 (3D)        2O13 (3D)    
Secondary accessions: Q9P131

Explore the universe of human proteins at neXtProt for CSRP3: NX_P50461

Explore proteomics data for CSRP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CSRP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003467.1  
    ENSEMBL proteins: 
     ENSP00000431813   ENSP00000265968  

    CSRP3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CSRP3
    OriGene Protein Over-expression Lysate for CSRP3
    OriGene MassSpec for CSRP3
    OriGene Custom Protein Services for CSRP3
    GenScript Custom Purified and Recombinant Proteins Services for CSRP3
    Novus Biologicals CSRP3 Proteins
    Novus Biologicals CSRP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CSRP3

     
    Search eBioscience for Proteins for CSRP3 

     
    antibodies-online proteins for CSRP3 (7 products) 

     
    antibodies-online peptides for CSRP3

    CSRP3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CSRP3
    OriGene Custom Antibody Services for CSRP3
    Novus Biologicals CSRP3 Antibodies
    Abcam antibodies for CSRP3
    Cloud-Clone Corp. Antibodies for CSRP3
    ThermoFisher Antibodies for CSRP3
    antibodies-online antibodies for CSRP3 (25 products) 

    CSRP3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CSRP3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CSRP3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CSRP3
    Cloud-Clone Corp. CLIAs for CSRP3
    Search eBioscience for ELISAs for CSRP3 
    antibodies-online kits for CSRP3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry P50461

    ProtoNet protein and cluster: P50461

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: CSRP3_HUMAN, P50461
    Similarity: Contains 2 LIM zinc-binding domains


    Find genes that share domains with CSRP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSRP3_HUMAN, P50461
    Function: Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic
    structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that
    promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to
    the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity)

         Genatlas biochemistry entry for CSRP3:
    Lim only domain protein,cysteine and glycine rich,expressed in cardiac and skeletal muscles,likely involved in the
    determination of cell lineage and regulation of cell differentiation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12127981
    GO:0008270zinc ion binding IEA--
    GO:0008307structural constituent of muscle IMP12507422
    GO:0031433telethonin binding IPI15582318
    GO:0042805actinin binding ISS12507422
         
    Find genes that share ontologies with CSRP3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CSRP3:
     Increased cilium length after  

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Csrp3):
     cardiovascular system  growth/size/body  homeostasis/metabolism  mortality/aging  muscle 
     respiratory system 

    Find genes that share phenotypes with CSRP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Csrp3tm1Crni for CSRP3

       genOway: Develop your customized and physiologically relevant rodent model for CSRP3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CSRP3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CSRP3
    SwitchGear 3'UTR luciferase reporter plasmidCSRP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CSRP3
    Predesigned siRNA for gene silencing in human, mouse, rat CSRP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CSRP3

    Clone
    Products:
         
    OriGene clones in human, mouse for CSRP3 (see all 12)
    OriGene ORF clones in mouse, rat for CSRP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CSRP3 (NM_001127656)
    Sino Biological Human cDNA Clone for CSRP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSRP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSRP3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CSRP3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CSRP3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSRP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CSRP3_HUMAN, P50461: Nucleus (Potential). Cytoplasm. Cytoplasm, cytoskeleton (Potential). Cytoplasm, myofibril,
    sarcomere, Z line (By similarity). Note=Mainly cytoplasmic (By similarity). In the nucleus it associates with the
    actin cytoskeleton (Potential). In the Z line, found associated with GLRX3 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    nucleus3
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005856cytoskeleton IEA--
    GO:0030018Z disc IDA12507422

    Find genes that share ontologies with CSRP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSRP3
    Interactions:

        GeneGlobe Interaction Network for CSRP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for CSRP3 (P504611, 3 ENSP000002659684) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LDHDQ86WU23, ENSP000003000514I2D: score=2 STRING: ENSP00000300051
    MYOD1P151723, ENSP000002500034I2D: score=2 STRING: ENSP00000250003
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    NHLH1Q025753, ENSP000003021894I2D: score=1 STRING: ENSP00000302189
    SPTBP112773, ENSP000003743724I2D: score=1 STRING: ENSP00000374372
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002026regulation of the force of heart contraction ISS--
    GO:0003300cardiac muscle hypertrophy IMP12507422
    GO:0006874cellular calcium ion homeostasis ISS--
    GO:0007519skeletal muscle tissue development TAS7954791
    GO:0033365protein localization to organelle IMP12507422

    Find genes that share ontologies with CSRP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CSRP3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CSRP3 gene: 
    NM_003476.4  

    Unigene Cluster for CSRP3:

    Cysteine and glycine-rich protein 3 (cardiac LIM protein)
    Hs.83577  [show with all ESTs]
    Unigene Representative Sequence: NM_003476
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533783 ENST00000265968(uc001mpk.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CSRP3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CSRP3
    SwitchGear 3'UTR luciferase reporter plasmidCSRP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CSRP3
    Predesigned siRNA for gene silencing in human, mouse, rat CSRP3
    Clone
    Products:
         
    OriGene clones in human, mouse for CSRP3 (see all 12)
    OriGene ORF clones in mouse, rat for CSRP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CSRP3 (NM_001127656)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSRP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSRP3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CSRP3
    OriGene qSTAR qPCR primer pairs in human, mouse for CSRP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSRP3
      QuantiTect SYBR Green Assays in human, mouse, rat CSRP3
      QuantiFast Probe-based Assays in human, mouse, rat CSRP3

    Additional mRNA sequence: 

    AF121260.1 AK313289.1 BC005900.2 BC024010.1 BC057221.1 U20324.1 U49837.1 U72899.1 

    3 DOTS entries:

    DT.417558  DT.95161717  DT.120737913 

    Selected AceView cDNA sequences (see all 131):

    BM091412 U20324 F26127 AI018334 AI184982 AA328566 AU099575 AJ709361 
    U72899 AA179103 NM_003476 AA247199 AI147018 AI969927 BF222629 AA347358 
    AJ573688 AF121260 BC005900 F17381 AJ346411 BF574554 AI024704 BE856189 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CSRP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCGGAGAT
    CSRP3 Expression
    About this image


    CSRP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Eye (Sensory Organs)
             Cholinergic Amacrine Cells Inner Nuclear Layer
    CSRP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSRP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.83577

    UniProtKB/Swiss-Prot: CSRP3_HUMAN, P50461
    Tissue specificity: Cardiac and slow-twitch skeletal muscles

        Custom PCR Arrays for CSRP3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CSRP3
    OriGene qSTAR qPCR primer pairs in human, mouse for CSRP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSRP3
    QuantiTect SYBR Green Assays in human, mouse, rat CSRP3
    QuantiFast Probe-based Assays in human, mouse, rat CSRP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSRP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CSRP3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csrp31 , 5 cysteine and glycine-rich protein 31, 5 91.24(n)1
    97.94(a)1
      7 (31.11 cM)5
    130091  NM_001198841.11  NP_001185770.11 
     488303985 
    chicken
    (Gallus gallus)
    Aves CSRP31 cysteine and glycine-rich protein 3 (cardiac LIM protein) 79.27(n)
    89.12(a)
      422979  NM_001199486.1  NP_001186415.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSRP36
    cysteine and glycine-rich protein 3 (cardiac LIM p...
    89(a)
    1 ↔ 1
    1(56116552-56140945)
    African clawed frog
    (Xenopus laevis)
    Amphibia csrp3-A-prov2 muscle LIM protein 78.12(n)    AF272888.1 
    zebrafish
    (Danio rerio)
    Actinopterygii csrp31 cysteine and glycine-rich protein 3 (cardiac LIM protein) 68.67(n)
    75.41(a)
      450005  NM_001006026.1  NP_001006026.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlp84B3
    Mlp60A1
    cell differentiation3
    Muscle LIM protein at 60A1
    46(a)3
    55.89(n)1
    53.29(a)1
      378531  NM_001144278.21  NP_001137750.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mlp-16
    Protein MLP-1, isoform a
    50(a)
    1 → many
    III(5971530-5973664) WBGene00003375


    ENSEMBL Gene Tree for CSRP3 (if available)
    TreeFam Gene Tree for CSRP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CSRP3 gene
    CSRP22  CSRP12  CRIP22  CRIP32  ENSG000002573412  CRIP12  
    5 SIMAP similar genes for CSRP3 using alignment to 2 protein entries:     CSRP3_HUMAN (see all proteins):
    DKFZp686M148    CSRP1    CSRP2    CRIP2    CRIP3

    Find genes that share paralogs with CSRP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CSRP3 (see all 752)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs455506351,2,,4
    C,FCardiomyopathy, dilated 1M (CMD1M)4 pathogenic119138585(-) CAAACT/CGGGGC 2 /R /W mis16Minor allele frequency- C:0.00NS NA EU 6361
    VAR_0459324
    Cardiomyopathy, familial hypertrophic 12 (CMH12)4--see VAR_0459322 L P mis40--------
    VAR_0459344
    Cardiomyopathy, familial hypertrophic 12 (CMH12)4--see VAR_0459342 C G mis40--------
    rs1378527641,2
    Cpathogenic119134357(-) CCCCAA/GAGGGA 2 K R mis10--------
    rs1048942041,2
    Cpathogenic119134391(-) TCTACG/TGCAAG 2 G C mis10--------
    rs1378527651,2
    Cpathogenic119134427(-) TTGACA/CGCACG 2 S R mis10--------
    rs1048942051,2
    Cpathogenic119134432(-) GGCTCC/TTGACA 2 P L mis10--------
    rs347888421,2
    C--18915763(+) AGCCTT/-TTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1150282591,2
    F--19127691(+) GAGGAG/AGAGGA 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs19912491,2
    C,F,A,H--19127764(-) CACTAC/TGCATG 1 -- ds500142Minor allele frequency- T:0.40EA NA MN NS WA CSA 3734

    HapMap Linkage Disequilibrium report for CSRP3 (19203578 - 19232120 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CSRP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744177CNV Deletion23290073

    Human Gene Mutation Database (HGMD): CSRP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSRP3
    DNA2.0 Custom Variant and Variant Library Synthesis for CSRP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600824   
    OMIM disorders: 607482  612124  
    UniProtKB/Swiss-Prot: CSRP3_HUMAN, P50461
  • Cardiomyopathy, dilated 1M (CMD1M) [MIM:607482]: A disorder characterized by ventricular dilation and
    impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of
    premature death. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Cardiomyopathy, familial hypertrophic 12 (CMH12) [MIM:612124]: A hereditary heart disorder characterized
    by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The
    symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by
    exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high
    risk of cardiac failure and sudden cardiac death. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 8 diseases for CSRP3:    
    About MalaCards
    cardiomyopathy, dilated, 1m    cardiomyopathy, familial hypertrophic, 12    csrp3-related familial hypertrophic cardiomyopathy    csrp3-related dilated cardiomyopathy
    endocardial fibroelastosis    hypertrophic cardiomyopathy    dilated cardiomyopathy    cardiomyopathy, dilated, 1w

    2 diseases from the University of Copenhagen DISEASES database for CSRP3:
    Dilated cardiomyopathy     Hypertrophic cardiomyopathy

    Find genes that share disorders with CSRP3           About GenesLikeMe

    7 Novoseek inferred disease relationships for CSRP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dilated cardiomyopathy 70.7 6 9484605 (1), 11192363 (1), 14567970 (1), 15639480 (1) (see all 6)
    cardiomyopathy 47.6 4 17923363 (1), 20044516 (1)
    cardiac hypertrophy 47 1 19804115 (1)
    heart failure 46.2 3 15639480 (1), 15665106 (1), 19649232 (1)
    hypertrophy 1.42 1 12642365 (1)
    breast cancer 0 3 12906853 (2), 16331278 (1)
    cancer 0 2 19997957 (1), 12906853 (1)

    GeneTests: CSRP3
    GeneReviews: CSRP3
    Genetic Association Database (GAD): CSRP3
    Human Genome Epidemiology (HuGE) Navigator: CSRP3 (10 documents)

    Export disorders for CSRP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CSRP3 gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with CSRP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of a human LIM protein (CLP) to human chromosome 11p15.1 by fluorescence in situ hybridization. (PubMed id 7490106)1, 2, 3 Fung Y.W.... Liew C.C. (Genomics 1995)
    2. Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy. (PubMed id 12642359)1, 2, 9 Geier C....Osterziel K.J. (Circulation 2003)
    3. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. (PubMed id 12507422)1, 2, 9 Knoell R.... Chien K.R. (Cell 2002)
    4. Structure and dynamics of the human muscle LIM protein. (PubMed id 19230835)1, 2, 9 Schallus T.... Muhle-Goll C. (FEBS Lett. 2009)
    5. Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy. (PubMed id 18505755)1, 2, 9 Geier C.... Ozcelik C. (Hum. Mol. Genet. 2008)
    6. The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy. (PubMed id 19293840)1, 4, 9 MA...ber L. (Eur. J. Hum. Genet. 2009)
    7. Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy. (PubMed id 19412328)1, 4, 9 Hershberger R.E....Litt M. (Clin Transl Sci 2008)
    8. A novel custom resequencing array for dilated cardiomyopathy. (PubMed id 20474083)1, 4 Zimmerman R.S....Funke B.H. (Genet. Med. 2010)
    9. Common susceptibility variants examined for association with dilated cardiomyopathy. (PubMed id 20201937)1, 4 Rampersaud E....Martin E.R. (Ann. Hum. Genet. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8048 HGNC: 2472 AceView: CSRP3 Ensembl:ENSG00000129170 euGenes: HUgn8048
    ECgene: CSRP3 H-InvDB: CSRP3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CSRP3 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=CSRP3[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CSRP3 gene:
    Search GeneIP for patents involving CSRP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CSRP3   OriGene RNAi products in human, mouse, rat for CSRP3  
     OriGene qPCR primer pairs and template standards for CSRP3   OriGene Protein Over-expression Lysate for CSRP3  
     OriGene MassSpec for CSRP3   OriGene clones in human, mouse for CSRP3  
     OriGene qSTAR qPCR primer pairs in human, mouse for CSRP3   OriGene Purified Protein for CSRP3  
     OriGene ORF clones in mouse, rat for CSRP3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CSRP3   OriGene Custom Protein Services for CSRP3  

     
     
     Block miRNA regulation of human, mouse, rat CSRP3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CSRP3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSRP3 Predesigned siRNA for gene silencing in human, mouse, rat CSRP3
     QuantiFast Probe-based Assays in human, mouse, rat CSRP3 QuantiTect SYBR Green Assays in human, mouse, rat CSRP3
     Custom PCR Arrays for CSRP3 Search Chromatin IP Primers for CSRP3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSRP3  GeneGlobe Interaction Network for CSRP3
     Regulatory tfbs in CSRP3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CSRP3 GenScript cDNA clones with any tag delivered in your preferred vector for CSRP3
     GenScript Custom Assay Services for CSRP3 GenScript Custom overexpressing Cell Line Services for CSRP3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CSRP3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CSRP3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CSRP3 antibodies
     CSRP3 proteins
     CSRP3 lysates
     Antibodies for CSRP3
     See all of Abcam's Antibodies, Kits and Proteins for CSRP3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CSRP3
     Antibodies for CSRP3
     ELISAs for CSRP3
     CLIAs for CSRP3



     Browse ESI BIO Cell Lines and PureStem Progenitors for CSRP3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSRP3
     SwitchGear 3'UTR luciferase reporter plasmids for CSRP3
     SwitchGear Promoter luciferase reporter plasmids for CSRP3
     ThermoFisher Antibodies for CSRP3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSRP3
     Browse compounds at ApexBio
     Search Addgene for plasmids for CSRP3
      Search eBioscience for proteins for CSRP3
      Search eBioscience for elisas for CSRP3
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CSRP3
     antibodies-online antibodies for CSRP3 (25 products)
     antibodies-online kits for CSRP3 (4 products)
     antibodies-online peptides for CSRP3
     antibodies-online proteins for CSRP3 (7 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CSRP3 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4