Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSRP2 Gene

protein-coding   GIFtS: 62
GCID: GC12M077185

Cysteine And Glycine-Rich Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cysteine And Glycine-Rich Protein 21 2     LMO-52 3
LMO52 3 5     SmLIM2 3
Cysteine-Rich Protein 22 3     LIM Domain Only Protein 52 3
Smooth Muscle Cell LIM Protein2 3     LIM Domain Only 5, Smooth Muscle2
CRP22 3     SMLIM3

External Ids:    HGNC: 24701   Entrez Gene: 14662   Ensembl: ENSG000001751837   OMIM: 6018715   UniProtKB: Q165273   

Export aliases for CSRP2 gene to outside databases

Previous GC identifers: GC12M076841 GC12M077594 GC12M075754 GC12M074305


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSRP2 Gene:
CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in
regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the
cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in
regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. (provided by RefSeq, Jul 2008)

GeneCards Summary for CSRP2 Gene: 
CSRP2 (cysteine and glycine-rich protein 2) is a protein-coding gene. Diseases associated with CSRP2 include hepatitis, and prostatitis, and among its related super-pathways are Immune response IL-23 signaling pathway. GO annotations related to this gene include molecular_function and zinc ion binding. An important paralog of this gene is CSRP1.

UniProtKB/Swiss-Prot: CSRP2_HUMAN, Q16527
Function: Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell
proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system

Gene Wiki entry for CSRP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSRP2 gene promoter:
         HOXA9B   HOXA9   TBP   Elk-1   Meis-1b   FOXO4   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSRP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CSRP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSRP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.1   Ensembl cytogenetic band:  12q21.2   HGNC cytogenetic band: 12q21.1

CSRP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSRP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M077185:  view genomic region     (about GC identifiers)

Start:
77,252,495 bp from pter      End:
77,272,840 bp from pter
Size:
20,346 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CSRP2_HUMAN, Q16527 (See protein sequence)
Recommended Name: Cysteine and glycine-rich protein 2  
Size: 193 amino acids; 20954 Da
Subunit: Interacts with CSRP2BP. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with
GLRX3 (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q93030

Explore the universe of human proteins at neXtProt for CSRP2: NX_Q16527

Explore proteomics data for CSRP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16527

  • CSRP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CSRP2 Protein Expression
    REFSEQ proteins: NP_001312.1  
    ENSEMBL proteins: 
     ENSP00000310901   ENSP00000449824   ENSP00000450056   ENSP00000450143  

    Human Recombinant Protein Products for CSRP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CSRP2
    OriGene Protein Over-expression Lysate for CSRP2
    OriGene MassSpec for CSRP2 
    OriGene Custom Protein Services for CSRP2
    GenScript Custom Purified and Recombinant Proteins Services for CSRP2
    Novus Biologicals CSRP2 Proteins
    Novus Biologicals CSRP2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CSRP2
    Cloud-Clone Corp. Proteins for CSRP2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8626582

    CSRP2 for ontologies           About GeneDecksing



    CSRP2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CSRP2
    OriGene Antibodies for CSRP2
    OriGene Custom Antibody Services for CSRP2
    GenScript Custom Superior Antibodies Services for CSRP2
    Novus Biologicals CSRP2 Antibodies
    Abcam antibodies for CSRP2
    Cloud-Clone Corp. Antibodies for CSRP2 
    ThermoFisher Antibodies for CSRP2
    LSBio Antibodies in human, mouse, rat for CSRP2 

    Assay Products for CSRP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CSRP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CSRP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CSRP2 
    Cloud-Clone Corp. CLIAs for CSRP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q16527

    ProtoNet protein and cluster: Q16527

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: CSRP2_HUMAN, Q16527
    Similarity: Contains 2 LIM zinc-binding domains


    CSRP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSRP2_HUMAN, Q16527
    Function: Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell
    proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system

         Genatlas biochemistry entry for CSRP2:
    cysteine and glycine rich protein 2,putatively involved in cellular growth control,likely involved in the
    determination of cell lineage and regulation of cell differentiation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    CSRP2 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Csrp2):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  integument  muscle 
     nervous system 

    CSRP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CSRP2: Csrp2tm1Rawe Csrp2tm1Sfy Csrp2tm1.1Acsc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CSRP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSRP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSRP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSRP2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSRP2
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CSRP2 (see all 10):
    hsa-miR-199b-3p hsa-miR-513a-5p hsa-miR-27a hsa-miR-199a-3p hsa-miR-128 hsa-miR-3129-5p hsa-miR-3681* hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidCSRP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CSRP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSRP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CSRP2
    Sirion Biotech Customized adenovirus for overexpression of CSRP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CSRP2 (see all 8)
    OriGene ORF clones in mouse, rat for CSRP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CSRP2 (NM_001321)
    Sino Biological Human cDNA Clone for CSRP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSRP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSRP2
    Sirion Biotech Customized lentivirus for stable overexpression of CSRP2 
                         Customized lentivirus expression plasmids for stable overexpression of CSRP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CSRP2
    Search LifeMap BioReagents cell lines for CSRP2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSRP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CSRP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development PDGF signaling via STATs and NF-kB
    Immune response IL-10 signaling pathway0.38
    2ATF-2 transcription factor network
    ATF-2 transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CSRP2
        Immune response IL-10 signaling pathway


    1 GeneGo (Thomson Reuters) Pathway for CSRP2
        Immune response IL-10 signaling pathway

    1 BioSystems Pathway for CSRP2
        ATF-2 transcription factor network




    CSRP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSRP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for CSRP2 (Q165273 ENSP000003109014) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIAS1O759253, ENSP000002496364I2D: score=3 STRING: ENSP00000249636
    CSRP2BPQ9H8E83, ENSP000002788164I2D: score=2 STRING: ENSP00000278816
    EEF1A1P681043, ENSP000003300544I2D: score=1 STRING: ENSP00000330054
    GABARAPL1Q9H0R83I2D: score=1 
    SLC2A4P146723I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0030154cell differentiation NAS8626582

    CSRP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CSRP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CSRP2

    1 Novoseek inferred chemical compound relationship for CSRP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 53.2 7 11672422 (2), 19052772 (1), 16735029 (1), 9722554 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about CSRP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CSRP2 gene: 
    NM_001321.1  

    Unigene Cluster for CSRP2:

    Cysteine and glycine-rich protein 2
    Hs.530904  [show with all ESTs]
    Unigene Representative Sequence: AB209321
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311083(uc001syl.1) ENST00000548783 ENST00000552330 ENST00000546966
    ENST00000547435 ENST00000547557 ENST00000551725
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSRP2
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CSRP2 (see all 10):
    hsa-miR-199b-3p hsa-miR-513a-5p hsa-miR-27a hsa-miR-199a-3p hsa-miR-128 hsa-miR-3129-5p hsa-miR-3681* hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidCSRP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CSRP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSRP2
    Clone
    Products:
         
    OriGene clones in human, mouse for CSRP2 (see all 8)
    OriGene ORF clones in mouse, rat for CSRP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CSRP2 (NM_001321)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSRP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSRP2
    Sirion Biotech Customized lentivirus for stable overexpression of CSRP2 
                         Customized lentivirus expression plasmids for stable overexpression of CSRP2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CSRP2
    OriGene qSTAR qPCR primer pairs in human, mouse for CSRP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSRP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSRP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSRP2

    Additional mRNA sequence: 

    AB209321.1 AK307205.1 AY349166.1 BC000992.2 BT019913.1 U46006.1 U57646.1 

    11 DOTS entries:

    DT.416006  DT.100668759  DT.100707276  DT.92423667  DT.95159933  DT.97839920  DT.120885188  DT.99941103 
    DT.102828074  DT.120788061  DT.95159932 

    24/150 AceView cDNA sequences (see all 150):

    BU623688 AW957703 BQ427526 W52188 AA955032 AW161336 W63677 BU683308 
    CR611980 AI384066 CD677913 AI433389 BF432851 BC000992 NM_001321 AA583836 
    BX461098 AI368461 AW162313 AA213374 BU622452 BM987325 AI051653 BE349465 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CSRP2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                      -                           
    SP2:                    -                 -                           
    SP3:                                                                  


    ECgene alternative splicing isoforms for CSRP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSRP2 expression in normal human tissues (normalized intensities)      CSRP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAGTAAGA
    CSRP2 Expression
    About this image


    CSRP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Colon (Gastrointestinal Tract)
             Appendix   
     
     Smooth Muscle (Muscoskeletal System)
             Smooth muscle-like cells ( Generation of endothelial progenitor cells and smooth...
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Mesoderm (Gastrulation Derivatives)
             PureStem Z11, Meso Progenitor
     
     Skeletal Muscle (Muscoskeletal System)
             Extraocular Muscles

    See CSRP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSRP2

    SOURCE GeneReport for Unigene cluster: Hs.530904

    UniProtKB/Swiss-Prot: CSRP2_HUMAN, Q16527
    Tissue specificity: Highly expressed in the aorta, but not in heart and skeletal muscle

        SABiosciences Custom PCR Arrays for CSRP2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CSRP2
    OriGene qSTAR qPCR primer pairs in human, mouse for CSRP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSRP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSRP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSRP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSRP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CSRP2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csrp21 , 5 cysteine and glycine-rich protein 21, 5 91.88(n)1
    99.48(a)1
      10 (57.84 cM)5
    130081  NM_007792.41  NP_031818.31 
     1109201765 
    chicken
    (Gallus gallus)
    Aves CSRP21 cysteine and glycine-rich protein 2 82.21(n)
    96.37(a)
      396128  NM_205208.1  NP_990539.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSRP26
    Uncharacterized protein
    89(a)
    1 ↔ 1
    5(40851891-40870747)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151382 Xenopus laevis transcribed sequence with moderate similarity more 80.13(n)    BJ617165.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc777402 hypothetical protein MGC77740 77.88(n)   393871  BC064303.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlp84B3 cell differentiation 43(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea mlp-16
    Protein MLP-1, isoform b
    35(a)
    1 → many
    III(5971530-5973664)


    ENSEMBL Gene Tree for CSRP2 (if available)
    TreeFam Gene Tree for CSRP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSRP2 gene
    CSRP12  CRIP22  CRIP32  ENSG000002573412  CRIP12  CSRP32  
    5 SIMAP similar genes for CSRP2 using alignment to 3 protein entries:     CSRP2_HUMAN (see all proteins):
    DKFZp686P2249    DKFZp686M148    CSRP1    CSRP3    CRIP3

    CSRP2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CSRP2
    PGOHUM00000237734 PGOHUM00000237774


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/474 SNPs in CSRP2 are shown (see all 474)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs568968481,2
    C--74314052(+) AAAAA-/A/AA  
            
    GATTA
    1 -- int12NA 4
    rs563853771,2
    --77252026(+) GAGACA/GGAGTC 1 -- ds50010--------
    rs1811152461,2
    --77252255(+) ATCTCA/GGCCTC 1 -- ds50010--------
    rs1844022061,2
    C--77252285(+) GGCGTA/GAGCTA 1 -- ds50010--------
    rs1893329841,2
    --77252287(+) CGTAAA/GCTACC 1 -- ds50010--------
    rs1807752211,2
    C--77252289(+) TAAGCC/TACCGC 1 -- ds50010--------
    rs1387372741,2
    --77252292(+) GCTACC/TGCGCC 1 -- ds50010--------
    rs1865396921,2
    C--77252293(+) CTACCA/GCGCCC 1 -- ds50010--------
    rs2019102151,2
    --77252411(+) AACAA-/AGGT  
            
    AGGGA
    1 -- ds50010--------
    rs1909924211,2
    --77252618(+) AGGGCA/GATATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CSRP2 (77252495 - 77272840 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CSRP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899318CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CSRP2
    DNA2.0 Custom Variant and Variant Library Synthesis for CSRP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601871    OMIM disorders: --

    2 diseases for CSRP2:    About MalaCards
    hepatitis    prostatitis


    CSRP2 for disorders           About GeneDecksing


    Export disorders for CSRP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSRP2 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with CSRP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2. (PubMed id 9286703)1, 2, 3, 9 Weiskirchen R....Bister K. (1997)
    2. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein. (PubMed id 10924333)1, 2, 9 Weiskirchen R. and Gressner A.M. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells. (PubMed id 8626582)1, 2 Jain M.... Lee M.-E. (1996)
    5. The cysteine-rich protein family of highly related LIM domain proteins. (PubMed id 7499425)1, 3 Weiskirchen R.... Beckerle M.C. (1995)
    6. LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1. (PubMed id 11672422)1, 9 Weiskirchen R.... Gressner A.M. (2001)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1466 HGNC: 2470 AceView: CSRP2 Ensembl:ENSG00000175183 euGenes: HUgn1466
    ECgene: CSRP2 H-InvDB: CSRP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSRP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSRP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CSRP2 gene:
    Search GeneIP for patents involving CSRP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CSRP2 (CSRP2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CSRP2   OriGene RNAi products in human, mouse, rat for CSRP2  
     OriGene qPCR primer pairs and template standards for CSRP2   OriGene Protein Over-expression Lysate for CSRP2  
     OriGene MassSpec something-or-other for CSRP2   OriGene clones in human, mouse for CSRP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CSRP2   OriGene Purified Protein for CSRP2  
     OriGene ORF clones in mouse, rat for CSRP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CSRP2   OriGene Custom Protein Services for CSRP2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CSRP2
     QIAGEN SeqTarget long-range PCR primers for resequencing CSRP2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSRP2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSRP2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSRP2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSRP2
     GenScript Custom Purified and Recombinant Proteins Services for CSRP2 GenScript cDNA clones with any tag delivered in your preferred vector for CSRP2
     GenScript Custom Assay Services for CSRP2 GenScript Custom Superior Antibodies Services for CSRP2
     GenScript Custom overexpressing Cell Line Services for CSRP2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CSRP2 promoter
     Search Chromatin IP Primers for CSRP2
     RT2 qPCR Primer Assay in human, mouse, rat CSRP2
     GNC Network for CSRP2
     SABiosciences Custom PCR Arrays for CSRP2
     Search Tocris compounds for CSRP2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CSRP2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CSRP2 antibodies
     CSRP2 proteins
     CSRP2 lysates
     Antibodies for CSRP2
     See all of Abcam's Antibodies, Kits and Proteins for CSRP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CSRP2




     Proteins for CSRP2
     Antibodies for CSRP2
     ELISAs for CSRP2
     CLIAs for CSRP2
     Search LifeMap BioReagents cell lines for CSRP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSRP2
     SwitchGear 3'UTR luciferase reporter plasmids for CSRP2
     SwitchGear Promoter luciferase reporter plasmids for CSRP2
     ThermoFisher Antibodies for CSRP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSRP2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CSRP2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSRP2
    Customized:
     lentivirus for stable overexpression of CSRP2
     lentivirus expression plasmids for stable overexpression of CSRP2
     adenovirus for overexpression of CSRP2
     LSBio Antibodies in human, mouse, rat for CSRP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CSRP2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4