Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CSRP2 Gene

Aliases for CSRP2 Gene

  • Cysteine And Glycine Rich Protein 2 2 3 5
  • Smooth Muscle Cell LIM Protein 3 4
  • LIM Domain Only Protein 5 3 4
  • Cysteine-Rich Protein 2 3 4
  • LMO-5 3 4
  • SmLIM 3 4
  • CRP2 3 4
  • LMO5 3 4
  • Cysteine And Glycine-Rich Protein 2 3
  • LIM Domain Only 5, Smooth Muscle 3

External Ids for CSRP2 Gene

Previous GeneCards Identifiers for CSRP2 Gene

  • GC12M077594
  • GC12M077185
  • GC12M075754
  • GC12M074305

Summaries for CSRP2 Gene

Entrez Gene Summary for CSRP2 Gene

  • CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for CSRP2 Gene

CSRP2 (Cysteine And Glycine Rich Protein 2) is a Protein Coding gene. Among its related pathways are Immune response IL-23 signaling pathway and ATF-2 transcription factor network. An important paralog of this gene is CSRP1.

UniProtKB/Swiss-Prot for CSRP2 Gene

  • Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

Gene Wiki entry for CSRP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRP2 Gene

Genomics for CSRP2 Gene

Regulatory Elements for CSRP2 Gene

Enhancers for CSRP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CSRP2 on UCSC Golden Path with GeneCards custom track

Promoters for CSRP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CSRP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CSRP2 Gene

Chromosome:
12
Start:
76,858,715 bp from pter
End:
76,879,060 bp from pter
Size:
20,346 bases
Orientation:
Minus strand

Genomic View for CSRP2 Gene

Genes around CSRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRP2 Gene

Proteins for CSRP2 Gene

  • Protein details for CSRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16527-CSRP2_HUMAN
    Recommended name:
    Cysteine and glycine-rich protein 2
    Protein Accession:
    Q16527
    Secondary Accessions:
    • Q93030

    Protein attributes for CSRP2 Gene

    Size:
    193 amino acids
    Molecular mass:
    20954 Da
    Quaternary structure:
    • Interacts with CSRP2BP. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with GLRX3 (By similarity).

neXtProt entry for CSRP2 Gene

Post-translational modifications for CSRP2 Gene

  • Ubiquitination at Lys 69
  • Modification sites at PhosphoSitePlus

Other Protein References for CSRP2 Gene

Antibody Products

  • Abcam antibodies for CSRP2

No data available for DME Specific Peptides for CSRP2 Gene

Domains & Families for CSRP2 Gene

Gene Families for CSRP2 Gene

Protein Domains for CSRP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CSRP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16527

UniProtKB/Swiss-Prot:

CSRP2_HUMAN :
  • Contains 2 LIM zinc-binding domains.
Domain:
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with CSRP2: view

Function for CSRP2 Gene

Molecular function for CSRP2 Gene

GENATLAS Biochemistry:
cysteine and glycine rich protein 2,putatively involved in cellular growth control,likely involved in the determination of cell lineage and regulation of cell differentiation
UniProtKB/Swiss-Prot Function:
Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

Gene Ontology (GO) - Molecular Function for CSRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CSRP2: view
genes like me logo Genes that share phenotypes with CSRP2: view

Animal Models for CSRP2 Gene

MGI Knock Outs for CSRP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSRP2 Gene

Localization for CSRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSRP2 Gene COMPARTMENTS Subcellular localization image for CSRP2 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CSRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8626582
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CSRP2: view

Pathways & Interactions for CSRP2 Gene

genes like me logo Genes that share pathways with CSRP2: view

Pathways by source for CSRP2 Gene

1 BioSystems pathway for CSRP2 Gene
1 GeneGo (Thomson Reuters) pathway for CSRP2 Gene

Gene Ontology (GO) - Biological Process for CSRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation NAS 8626582
GO:0045445 myoblast differentiation IEA --
genes like me logo Genes that share ontologies with CSRP2: view

No data available for SIGNOR curated interactions for CSRP2 Gene

Drugs & Compounds for CSRP2 Gene

(1) Drugs for CSRP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CSRP2: view

Transcripts for CSRP2 Gene

Unigene Clusters for CSRP2 Gene

Cysteine and glycine-rich protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSRP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3:

Relevant External Links for CSRP2 Gene

GeneLoc Exon Structure for
CSRP2
ECgene alternative splicing isoforms for
CSRP2

Expression for CSRP2 Gene

mRNA expression in normal human tissues for CSRP2 Gene

mRNA differential expression in normal tissues according to GTEx for CSRP2 Gene

This gene is overexpressed in Artery - Tibial (x6.3) and Artery - Coronary (x4.3).

Protein differential expression in normal tissues from HIPED for CSRP2 Gene

This gene is overexpressed in Amniocyte (20.8), Placenta (11.2), and Uterus (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSRP2 Gene



Protein tissue co-expression partners for CSRP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CSRP2 Gene:

CSRP2

SOURCE GeneReport for Unigene cluster for CSRP2 Gene:

Hs.530904

mRNA Expression by UniProt/SwissProt for CSRP2 Gene:

Q16527-CSRP2_HUMAN
Tissue specificity: Highly expressed in the aorta, but not in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with CSRP2: view

Primer Products

Orthologs for CSRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSRP2 34
  • 93.78 (n)
  • 100 (a)
CSRP2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC475409 34
  • 85.26 (n)
  • 93.51 (a)
CSRP2 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csrp2 34
  • 91.88 (n)
  • 99.48 (a)
Csrp2 16
Csrp2 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSRP2 34
  • 99.65 (n)
  • 100 (a)
CSRP2 35
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csrp2 34
  • 93.61 (n)
  • 99.48 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CSRP2 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves CSRP2 34
  • 82.21 (n)
  • 96.37 (a)
CSRP2 35
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSRP2 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csrp2 34
  • 78.82 (n)
  • 88.02 (a)
Str.6131 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15138 34
zebrafish
(Danio rerio)
Actinopterygii csrp2 34
  • 75.99 (n)
  • 87.05 (a)
zgc77740 34
csrp2 35
  • 87 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8116 34
fruit fly
(Drosophila melanogaster)
Insecta Mlp84B 36
  • 43 (a)
Mlp84B 34
  • 55.56 (n)
  • 51.11 (a)
Mlp60A 35
  • 20 (a)
ManyToMany
Mlp84B 35
  • 20 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012305 34
  • 55.43 (n)
  • 49.72 (a)
worm
(Caenorhabditis elegans)
Secernentea mlp-1 34
  • 50.83 (n)
  • 46.81 (a)
mlp-1 35
  • 48 (a)
OneToMany
Species where no ortholog for CSRP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRP2 Gene

ENSEMBL:
Gene Tree for CSRP2 (if available)
TreeFam:
Gene Tree for CSRP2 (if available)

Paralogs for CSRP2 Gene

Paralogs for CSRP2 Gene

(5) SIMAP similar genes for CSRP2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CSRP2 Gene

genes like me logo Genes that share paralogs with CSRP2: view

Variants for CSRP2 Gene

Sequence variations from dbSNP and Humsavar for CSRP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1587110 -- 76,879,430(+) AGTCA(C/T)GGGCC upstream-variant-2KB
rs7308963 -- 76,863,828(+) CCTAA(C/T)ACAGA intron-variant
rs7312867 -- 76,862,487(+) AGTGA(A/G)CCGAG intron-variant, downstream-variant-500B
rs2047226 -- 76,862,697(+) AAAAA(C/T)AAGAA intron-variant, utr-variant-3-prime
rs2047227 -- 76,862,901(+) GAAAT(G/T)GAAGT intron-variant, reference, missense

Variation tolerance for CSRP2 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSRP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSRP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CSRP2 Gene

Disorders for CSRP2 Gene

Relevant External Links for CSRP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSRP2

No disorders were found for CSRP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSRP2 Gene

Publications for CSRP2 Gene

  1. Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2. (PMID: 9286703) Weiskirchen R. … Bister K. (Genomics 1997) 2 3 4 22 65
  2. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein. (PMID: 10924333) Weiskirchen R. … Gressner A.M. (Biochem. Biophys. Res. Commun. 2000) 3 4 22 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1. (PMID: 11672422) Weiskirchen R. … Gressner A.M. (Biochem. J. 2001) 3 22 65
  5. Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells. (PMID: 8626582) Jain M. … Lee M.-E. (J. Biol. Chem. 1996) 3 4 65

Products for CSRP2 Gene

Sources for CSRP2 Gene

Content