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CSRP2 Gene

protein-coding   GIFtS: 62
GCID: GC12M077185

Cysteine And Glycine-Rich Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteine And Glycine-Rich Protein 21 2     LMO-52 3
LMO52 3 5     SmLIM2 3
Cysteine-Rich Protein 22 3     LIM Domain Only Protein 52 3
Smooth Muscle Cell LIM Protein2 3     LIM Domain Only 5, Smooth Muscle2
CRP22 3     SMLIM3

External Ids:    HGNC: 24701   Entrez Gene: 14662   Ensembl: ENSG000001751837   OMIM: 6018715   UniProtKB: Q165273   

Export aliases for CSRP2 gene to outside databases

Previous GC identifers: GC12M076841 GC12M077594 GC12M075754 GC12M074305


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSRP2 Gene:
CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in
regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the
cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in
regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. (provided by RefSeq, Jul 2008)

GeneCards Summary for CSRP2 Gene:
CSRP2 (cysteine and glycine-rich protein 2) is a protein-coding gene. Diseases associated with CSRP2 include hepatitis, and prostatitis. An important paralog of this gene is CSRP1.

UniProtKB/Swiss-Prot: CSRP2_HUMAN, Q16527
Function: Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell
proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system

Gene Wiki entry for CSRP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSRP2 gene promoter:
         HOXA9B   HOXA9   TBP   Elk-1   Meis-1b   FOXO4   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSRP2 promoter sequence
   Search Chromatin IP Primers for CSRP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSRP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.1   Ensembl cytogenetic band:  12q21.2   HGNC cytogenetic band: 12q21.1

CSRP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSRP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M077185:  view genomic region     (about GC identifiers)

Start:
77,252,495 bp from pter      End:
77,272,840 bp from pter
Size:
20,346 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CSRP2_HUMAN, Q16527 (See protein sequence)
Recommended Name: Cysteine and glycine-rich protein 2  
Size: 193 amino acids; 20954 Da
Subunit: Interacts with CSRP2BP. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with
GLRX3 (By similarity)
Secondary accessions: Q93030

Explore the universe of human proteins at neXtProt for CSRP2: NX_Q16527

Explore proteomics data for CSRP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys65, Lys69
  • Modification sites at PhosphoSitePlus

  • See CSRP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001312.1  
    ENSEMBL proteins: 
     ENSP00000310901   ENSP00000449824   ENSP00000450056   ENSP00000450143  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q16527

    ProtoNet protein and cluster: Q16527

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: CSRP2_HUMAN, Q16527
    Similarity: Contains 2 LIM zinc-binding domains


    CSRP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSRP2_HUMAN, Q16527
    Function: Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell
    proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system

         Genatlas biochemistry entry for CSRP2:
    cysteine and glycine rich protein 2,putatively involved in cellular growth control,likely involved in the
    determination of cell lineage and regulation of cell differentiation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    CSRP2 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Csrp2):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  integument  muscle 
     nervous system 

    CSRP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CSRP2: Csrp2tm1Rawe Csrp2tm1Sfy Csrp2tm1.1Acsc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CSRP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CSRP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSRP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSRP2

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CSRP2 (see all 10):
    hsa-miR-199b-3p hsa-miR-513a-5p hsa-miR-27a hsa-miR-199a-3p hsa-miR-128 hsa-miR-3129-5p hsa-miR-3681* hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidCSRP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CSRP2

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    GenScript: all cDNA clones in your preferred vector: CSRP2 (NM_001321)
    Sino Biological Human cDNA Clone for CSRP2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSRP2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSRP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CSRP2_HUMAN, Q16527: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8626582

    CSRP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSRP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response IL 23 signaling pathway
    Immune response IL 10 signaling pathway0.38
    2ATF-2 transcription factor network
    ATF-2 transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CSRP2
        Immune response IL-10 signaling pathway

    1 BioSystems Pathway for CSRP2
        ATF-2 transcription factor network



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSRP2
    Interactions:

        GeneGlobe Interaction Network for CSRP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CSRP2 (Q165273 ENSP000003109014) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIAS1O759253, ENSP000002496364I2D: score=3 STRING: ENSP00000249636
    EEF1A1P681043, ENSP000003300544I2D: score=1 STRING: ENSP00000330054
    CSRP2BPQ9H8E83I2D: score=2 
    GABARAPL1Q9H0R83I2D: score=1 
    SLC2A4P146723I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0030154cell differentiation NAS8626582

    CSRP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CSRP2

    1 Novoseek inferred chemical compound relationship for CSRP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 53.2 7 11672422 (2), 19052772 (1), 16735029 (1), 9722554 (1) (see all 5)



    CSRP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CSRP2 gene: 
    NM_001321.1  

    Unigene Cluster for CSRP2:

    Cysteine and glycine-rich protein 2
    Hs.530904  [show with all ESTs]
    Unigene Representative Sequence: AB209321
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311083(uc001syl.1) ENST00000548783 ENST00000552330 ENST00000546966
    ENST00000547435 ENST00000547557 ENST00000551725
    miRNA
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    Block miRNA regulation of human, mouse, rat CSRP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSRP2 (see all 10):
    hsa-miR-199b-3p hsa-miR-513a-5p hsa-miR-27a hsa-miR-199a-3p hsa-miR-128 hsa-miR-3129-5p hsa-miR-3681* hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidCSRP2 3' UTR sequence
    Inhib. RNA
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    OriGene qPCR primer pairs and template standards for CSRP2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSRP2
      QuantiTect SYBR Green Assays in human, mouse, rat CSRP2
      QuantiFast Probe-based Assays in human, mouse, rat CSRP2

    Additional mRNA sequence: 

    AB209321.1 AK307205.1 AY349166.1 BC000992.2 BT019913.1 U46006.1 U57646.1 

    11 DOTS entries:

    DT.416006  DT.100668759  DT.100707276  DT.92423667  DT.95159933  DT.97839920  DT.120885188  DT.99941103 
    DT.102828074  DT.120788061  DT.95159932 

    Selected AceView cDNA sequences (see all 150):

    AW072648 AI051653 CR598239 W63677 BF432851 BX461098 AA553531 AW162313 
    AA583836 CD677913 BM987325 AI537636 BQ225537 AI368461 AA213374 BE349465 
    AI384066 AW162034 CR611980 AW161336 AA955032 BU623688 NM_001321 BQ427526 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CSRP2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                      -                           
    SP2:                    -                 -                           
    SP3:                                                                  


    ECgene alternative splicing isoforms for CSRP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSRP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAGTAAGA
    CSRP2 Expression
    About this image


    CSRP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Smooth Muscle (Muscoskeletal System)
             Smooth muscle-like cells
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Eye (Sensory Organs)
             Retina
     
     Skeletal Muscle (Muscoskeletal System)
             Extraocular Muscles
     
     Esophagus (Gastrointestinal Tract)
    CSRP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSRP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530904

    UniProtKB/Swiss-Prot: CSRP2_HUMAN, Q16527
    Tissue specificity: Highly expressed in the aorta, but not in heart and skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CSRP2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csrp21 , 5 cysteine and glycine-rich protein 21, 5 91.88(n)1
    99.48(a)1
      10 (57.84 cM)5
    130081  NM_007792.41  NP_031818.31 
     1109201765 
    chicken
    (Gallus gallus)
    Aves CSRP21 cysteine and glycine-rich protein 2 82.21(n)
    96.37(a)
      396128  NM_205208.1  NP_990539.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSRP26
    cysteine and glycine-rich protein 2
    89(a)
    1 ↔ 1
    5(40851891-40870747)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151382 Xenopus laevis transcribed sequence with moderate similarity more 80.13(n)    BJ617165.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc777402 hypothetical protein MGC77740 77.88(n)   393871  BC064303.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlp84B1 , 3 cell differentiation3
    Muscle LIM protein at 84B1
    43(a)3
    55.56(n)1
    51.11(a)1
      408491  NM_057774.51  NP_477122.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mlp-11 mlp-1 50.83(n)
    46.81(a)
      175847  NM_065900.2  NP_498301.2 


    ENSEMBL Gene Tree for CSRP2 (if available)
    TreeFam Gene Tree for CSRP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSRP2 gene
    CSRP12  CRIP22  CRIP32  ENSG000002573412  CRIP12  CSRP32  
    5 SIMAP similar genes for CSRP2 using alignment to 3 protein entries:     CSRP2_HUMAN (see all proteins):
    DKFZp686P2249    DKFZp686M148    CSRP1    CSRP3    CRIP3

    CSRP2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CSRP2
    PGOHUM00000237734 PGOHUM00000237774


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSRP2 (see all 474)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs568968481,2
    C--74314052(+) AAAAA-/A/AA  
            
    GATTA
    1 -- int12NA 4
    rs563853771,2
    --77252026(+) GAGACA/GGAGTC 1 -- ds50010--------
    rs1811152461,2
    --77252255(+) ATCTCA/GGCCTC 1 -- ds50010--------
    rs1844022061,2
    C--77252285(+) GGCGTA/GAGCTA 1 -- ds50010--------
    rs1893329841,2
    --77252287(+) CGTAAA/GCTACC 1 -- ds50010--------
    rs1807752211,2
    C--77252289(+) TAAGCC/TACCGC 1 -- ds50010--------
    rs1387372741,2
    --77252292(+) GCTACC/TGCGCC 1 -- ds50010--------
    rs1865396921,2
    C--77252293(+) CTACCA/GCGCCC 1 -- ds50010--------
    rs2019102151,2
    --77252411(+) AACAA-/AGGT  
            
    AGGGA
    1 -- ds50010--------
    rs1909924211,2
    --77252618(+) AGGGCA/GATATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CSRP2 (77252495 - 77272840 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CSRP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899318CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSRP2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601871    OMIM disorders: --

    3 diseases for CSRP2:    
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    hepatitis    prostatitis    endotheliitis


    CSRP2 for disorders           About GeneDecksing


    Export disorders for CSRP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSRP2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CSRP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2. (PubMed id 9286703)1, 2, 3, 9 Weiskirchen R.... Bister K. (Genomics 1997)
    2. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein. (PubMed id 10924333)1, 2, 9 Weiskirchen R. and Gressner A.M. (Biochem. Biophys. Res. Commun. 2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells. (PubMed id 8626582)1, 2 Jain M.... Lee M.-E. (J. Biol. Chem. 1996)
    5. The cysteine-rich protein family of highly related LIM domain proteins. (PubMed id 7499425)1, 3 Weiskirchen R.... Beckerle M.C. (J. Biol. Chem. 1995)
    6. LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1. (PubMed id 11672422)1, 9 Weiskirchen R.... Gressner A.M. (Biochem. J. 2001)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1466 HGNC: 2470 AceView: CSRP2 Ensembl:ENSG00000175183 euGenes: HUgn1466
    ECgene: CSRP2 H-InvDB: CSRP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CSRP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSRP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSRP2 gene:
    Search GeneIP for patents involving CSRP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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