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Aliases for CSRP2 Gene

Aliases for CSRP2 Gene

  • Cysteine And Glycine-Rich Protein 2 2 3
  • LMO5 3 4 6
  • Smooth Muscle Cell LIM Protein 3 4
  • LIM Domain Only Protein 5 3 4
  • Cysteine-Rich Protein 2 3 4
  • LMO-5 3 4
  • SmLIM 3 4
  • CRP2 3 4
  • LIM Domain Only 5, Smooth Muscle 3

External Ids for CSRP2 Gene

Previous GeneCards Identifiers for CSRP2 Gene

  • GC12M077594
  • GC12M077185
  • GC12M075754
  • GC12M074305

Summaries for CSRP2 Gene

Entrez Gene Summary for CSRP2 Gene

  • CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for CSRP2 Gene

CSRP2 (Cysteine And Glycine-Rich Protein 2) is a Protein Coding gene. Among its related pathways are ATF-2 transcription factor network and Immune response IL-23 signaling pathway. An important paralog of this gene is CSRP1.

UniProtKB/Swiss-Prot for CSRP2 Gene

  • Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system

Gene Wiki entry for CSRP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRP2 Gene

Genomics for CSRP2 Gene

Regulatory Elements for CSRP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CSRP2 Gene

Start:
76,858,715 bp from pter
End:
76,879,060 bp from pter
Size:
20,346 bases
Orientation:
Minus strand

Genomic View for CSRP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRP2 Gene

Proteins for CSRP2 Gene

  • Protein details for CSRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16527-CSRP2_HUMAN
    Recommended name:
    Cysteine and glycine-rich protein 2
    Protein Accession:
    Q16527
    Secondary Accessions:
    • Q93030

    Protein attributes for CSRP2 Gene

    Size:
    193 amino acids
    Molecular mass:
    20954 Da
    Quaternary structure:
    • Interacts with CSRP2BP. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with GLRX3 (By similarity).

neXtProt entry for CSRP2 Gene

Proteomics data for CSRP2 Gene at MOPED

Post-translational modifications for CSRP2 Gene

  • Ubiquitination at Lys65 and Lys69
  • Modification sites at PhosphoSitePlus

Other Protein References for CSRP2 Gene

No data available for DME Specific Peptides for CSRP2 Gene

Domains for CSRP2 Gene

Protein Domains for CSRP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CSRP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16527

UniProtKB/Swiss-Prot:

CSRP2_HUMAN :
  • Q16527
Domain:
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with CSRP2: view

No data available for Gene Families for CSRP2 Gene

Function for CSRP2 Gene

Molecular function for CSRP2 Gene

GENATLAS Biochemistry: cysteine and glycine rich protein 2,putatively involved in cellular growth control,likely involved in the determination of cell lineage and regulation of cell differentiation
UniProtKB/Swiss-Prot Function: Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system

Gene Ontology (GO) - Molecular Function for CSRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CSRP2: view
genes like me logo Genes that share phenotypes with CSRP2: view

Animal Models for CSRP2 Gene

MGI Knock Outs for CSRP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CSRP2 TF1323 Crp

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CSRP2 Gene

Localization for CSRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSRP2 Gene COMPARTMENTS Subcellular localization image for CSRP2 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CSRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8626582
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CSRP2: view

Pathways for CSRP2 Gene

genes like me logo Genes that share pathways with CSRP2: view

Pathways by source for CSRP2 Gene

1 BioSystems pathway for CSRP2 Gene
1 GeneGo (Thomson Reuters) pathway for CSRP2 Gene

Gene Ontology (GO) - Biological Process for CSRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0030154 cell differentiation NAS 8626582
genes like me logo Genes that share ontologies with CSRP2: view

Compounds for CSRP2 Gene

(1) Novoseek inferred chemical compound relationships for CSRP2 Gene

Compound -log(P) Hits PubMed IDs
cysteine 53.2 6
genes like me logo Genes that share compounds with CSRP2: view

Transcripts for CSRP2 Gene

Unigene Clusters for CSRP2 Gene

Cysteine and glycine-rich protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSRP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSRP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3:

Relevant External Links for CSRP2 Gene

GeneLoc Exon Structure for
CSRP2
ECgene alternative splicing isoforms for
CSRP2

Expression for CSRP2 Gene

mRNA expression in normal human tissues for CSRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSRP2 Gene

This gene is overexpressed in Artery - Tibial (6.3) and Artery - Coronary (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSRP2 Gene

SOURCE GeneReport for Unigene cluster for CSRP2 Gene Hs.530904

mRNA Expression by UniProt/SwissProt for CSRP2 Gene

Q16527-CSRP2_HUMAN
Tissue specificity: Highly expressed in the aorta, but not in heart and skeletal muscle
genes like me logo Genes that share expressions with CSRP2: view

In Situ Assay Products

Orthologs for CSRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSRP2 35
  • 99.65 (n)
  • 100 (a)
CSRP2 36
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSRP2 35
  • 93.78 (n)
  • 100 (a)
CSRP2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSRP2 36
  • 90 (a)
OneToOne
LOC475409 35
  • 85.26 (n)
  • 93.51 (a)
mouse
(Mus musculus)
Mammalia Csrp2 35
  • 91.88 (n)
  • 99.48 (a)
Csrp2 16
Csrp2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CSRP2 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csrp2 35
  • 93.61 (n)
  • 99.48 (a)
chicken
(Gallus gallus)
Aves CSRP2 35
  • 82.21 (n)
  • 96.37 (a)
CSRP2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSRP2 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15138 35
tropical clawed frog
(Silurana tropicalis)
Amphibia csrp2 35
  • 78.82 (n)
  • 88.02 (a)
Str.6131 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8116 35
zebrafish
(Danio rerio)
Actinopterygii csrp2 35
  • 75.99 (n)
  • 87.05 (a)
csrp2 36
  • 87 (a)
OneToOne
zgc77740 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012305 35
  • 55.43 (n)
  • 49.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mlp60A 36
  • 20 (a)
ManyToMany
Mlp84B 35
  • 55.56 (n)
  • 51.11 (a)
Mlp84B 36
  • 20 (a)
ManyToMany
Mlp84B 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea mlp-1 35
  • 50.83 (n)
  • 46.81 (a)
mlp-1 36
  • 48 (a)
OneToMany
Species with no ortholog for CSRP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRP2 Gene

ENSEMBL:
Gene Tree for CSRP2 (if available)
TreeFam:
Gene Tree for CSRP2 (if available)

Paralogs for CSRP2 Gene

Paralogs for CSRP2 Gene

Selected SIMAP similar genes for CSRP2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CSRP2 Gene

genes like me logo Genes that share paralogs with CSRP2: view

Variants for CSRP2 Gene

Sequence variations from dbSNP and Humsavar for CSRP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs762784 -- 76,865,630(-) GTAAA(A/C)CCACC intron-variant
rs762785 -- 76,865,987(-) AGCAG(C/T)GAAGA intron-variant
rs762786 -- 76,865,728(-) GTCTT(C/T)GGTTT intron-variant
rs1587110 -- 76,879,430(+) AGTCA(C/T)GGGCC upstream-variant-2KB
rs2047226 -- 76,862,697(+) AAAAA(C/T)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSRP2 Gene

Variant ID Type Subtype PubMed ID
nsv899318 CNV Loss 21882294

Relevant External Links for CSRP2 Gene

HapMap Linkage Disequilibrium report
CSRP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSRP2 Gene

Disorders for CSRP2 Gene

No disorders were found for CSRP2 Gene.

No data available for UniProtKB/Swiss-Prot for CSRP2 Gene

Publications for CSRP2 Gene

  1. Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2. (PMID: 9286703) Weiskirchen R. … Bister K. (Genomics 1997) 2 3 4 23
  2. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein. (PMID: 10924333) Weiskirchen R. … Gressner A.M. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  3. LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1. (PMID: 11672422) Weiskirchen R. … Gressner A.M. (Biochem. J. 2001) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells. (PMID: 8626582) Jain M. … Lee M.-E. (J. Biol. Chem. 1996) 3 4

Products for CSRP2 Gene

Sources for CSRP2 Gene

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