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Aliases for CSRP1 Gene

Aliases for CSRP1 Gene

  • Cysteine And Glycine-Rich Protein 1 2 3
  • CSRP 3 4 6
  • Epididymis Luminal Protein 141 3 4
  • Cysteine-Rich Protein 1 3 4
  • HEL-141 3 4
  • CRP1 3 4
  • CYRP 3 4
  • CRP 3 4
  • LIM-Domain Protein 3
  • D1S181E 3

External Ids for CSRP1 Gene

Previous Symbols for CSRP1 Gene

  • CYRP

Summaries for CSRP1 Gene

Entrez Gene Summary for CSRP1 Gene

  • This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

GeneCards Summary for CSRP1 Gene

CSRP1 (Cysteine And Glycine-Rich Protein 1) is a Protein Coding gene. Diseases associated with CSRP1 include pontiac fever and endocardial fibroelastosis. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. An important paralog of this gene is CRIP2.

UniProtKB/Swiss-Prot for CSRP1 Gene

  • Could play a role in neuronal development

Gene Wiki entry for CSRP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRP1 Gene

Genomics for CSRP1 Gene

Genomic Location for CSRP1 Gene

Start:
201,483,530 bp from pter
End:
201,509,456 bp from pter
Size:
25,927 bases
Orientation:
Minus strand

Genomic View for CSRP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRP1 Gene

Regulatory Elements for CSRP1 Gene

Proteins for CSRP1 Gene

  • Protein details for CSRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21291-CSRP1_HUMAN
    Recommended name:
    Cysteine and glycine-rich protein 1
    Protein Accession:
    P21291
    Secondary Accessions:
    • A8K268
    • Q5U0J2

    Protein attributes for CSRP1 Gene

    Size:
    193 amino acids
    Molecular mass:
    20567 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for CSRP1 Gene

Proteomics data for CSRP1 Gene at MOPED

Post-translational modifications for CSRP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CSRP1 Gene

Domains for CSRP1 Gene

Protein Domains for CSRP1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CSRP1_HUMAN
Domain:
  • Contains 2 LIM zinc-binding domains.:
    • P21291
genes like me logo Genes that share domains with CSRP1: view

No data available for Gene Families for CSRP1 Gene

Function for CSRP1 Gene

Molecular function for CSRP1 Gene

GENATLAS Biochemistry: cysteine and glycine rich protein,20.5kDa,expressed by a serum-inducible immediate response gene,likely involved in the determination of cell lineage and regulation of cell differentiation
UniProtKB/Swiss-Prot Function: Could play a role in neuronal development

Gene Ontology (GO) - Molecular Function for CSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CSRP1: view

Phenotypes for CSRP1 Gene

genes like me logo Genes that share phenotypes with CSRP1: view

Animal Models for CSRP1 Gene

MGI Knock Outs for CSRP1:

miRNA for CSRP1 Gene

miRTarBase miRNAs that target CSRP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CSRP1 Gene

Localization for CSRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSRP1 Gene COMPARTMENTS Subcellular localization image for CSRP1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CSRP1: view

Pathways for CSRP1 Gene

genes like me logo Genes that share pathways with CSRP1: view

Gene Ontology (GO) - Biological Process for CSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070527 platelet aggregation IMP 23382103
genes like me logo Genes that share ontologies with CSRP1: view

Compounds for CSRP1 Gene

(2) Novoseek inferred chemical compound relationships for CSRP1 Gene

Compound -log(P) Hits PubMed IDs
cysteine 51.7 8
zinc 48.6 5
genes like me logo Genes that share compounds with CSRP1: view

Transcripts for CSRP1 Gene

Unigene Clusters for CSRP1 Gene

Cysteine and glycine-rich protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSRP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - -
SP9: - -
SP10: - - - - - - - - - - - -
SP11: -
SP12: - - - - - - - - - - - -
SP13: - - - - -
SP14:

ExUns: 8f ^ 9a · 9b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for CSRP1 Gene

GeneLoc Exon Structure for
CSRP1
ECgene alternative splicing isoforms for
CSRP1

Expression for CSRP1 Gene

mRNA expression in normal human tissues for CSRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSRP1 Gene

This gene is overexpressed in Colon - Sigmoid (4.8), Artery - Tibial (4.5), and Esophagus - Muscularis (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSRP1 Gene

SOURCE GeneReport for Unigene cluster for CSRP1 Gene Hs.108080

genes like me logo Genes that share expressions with CSRP1: view

Orthologs for CSRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSRP1 36
  • 99.31 (n)
  • 100 (a)
CSRP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSRP1 36
  • 90.33 (n)
  • 96.37 (a)
CSRP1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSRP1 37
  • 97 (a)
OneToOne
LOC607054 36
  • 91.36 (n)
  • 97.41 (a)
mouse
(Mus musculus)
Mammalia Csrp1 36
  • 90.85 (n)
  • 99.48 (a)
Csrp1 16
Csrp1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSRP1 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSRP1 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csrp1 36
  • 89.29 (n)
  • 98.96 (a)
chicken
(Gallus gallus)
Aves CSRP1 36
  • 81.94 (n)
  • 90.62 (a)
CSRP1 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSRP1 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csrp1 36
  • 72.54 (n)
  • 81.35 (a)
zebrafish
(Danio rerio)
Actinopterygii csrp1 36
csrp1a 36
  • 74.13 (n)
  • 83.33 (a)
csrp1a 37
  • 83 (a)
OneToMany
csrp1b 37
  • 82 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mlp60A 37
  • 20 (a)
ManyToMany
Mlp84B 37
  • 20 (a)
ManyToMany
Mlp84B 38
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea mlp-1 37
  • 48 (a)
OneToMany
Species with no ortholog for CSRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRP1 Gene

ENSEMBL:
Gene Tree for CSRP1 (if available)
TreeFam:
Gene Tree for CSRP1 (if available)

Paralogs for CSRP1 Gene

Paralogs for CSRP1 Gene

Selected SIMAP similar genes for CSRP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CSRP1: view

Variants for CSRP1 Gene

Sequence variations from dbSNP and Humsavar for CSRP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15769 -- 201,496,265(-) GTGTG(G/T)TCAGA frameshift-variant
rs475416 -- 201,500,479(-) GAGAC(A/G)TCCTG intron-variant
rs485060 -- 201,503,206(-) GAAAT(A/C)CTACA intron-variant
rs494838 -- 201,483,345(-) GGTGG(C/T)GGGTG downstream-variant-500B
rs495886 -- 201,492,681(-) TTCTC(C/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSRP1 Gene

Variant ID Type Subtype PubMed ID
nsv467961 CNV Gain 19166990
nsv470776 CNV Gain 18288195
nsv832315 CNV Loss 17160897

Relevant External Links for CSRP1 Gene

HapMap Linkage Disequilibrium report
CSRP1

Disorders for CSRP1 Gene

(2) Novoseek inferred disease relationships for CSRP1 Gene

Disease -log(P) Hits PubMed IDs
sepsis 7.75 3
tumors 4.94 1

Relevant External Links for CSRP1

Genetic Association Database (GAD)
CSRP1
Human Genome Epidemiology (HuGE) Navigator
CSRP1
genes like me logo Genes that share disorders with CSRP1: view

No data available for UniProtKB/Swiss-Prot for CSRP1 Gene

Publications for CSRP1 Gene

  1. Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif. (PMID: 2115670) Liebhaber S.A. … Cooke N.E. (Nucleic Acids Res. 1990) 2 3 4
  2. Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes. (PMID: 20415737) Latonen L. … Laiho M. (Photodermatol Photoimmunol Photomed 2010) 3 23
  3. Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc. (PMID: 1374386) Wang X. … Cooke N.E. (J. Biol. Chem. 1992) 3 4
  4. Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization. (PMID: 9925910) Erdel M. … Weiskirchen R. (Cytogenet. Cell Genet. 1998) 2 3
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for CSRP1 Gene

Sources for CSRP1 Gene

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