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CSRP1 Gene

protein-coding   GIFtS: 60
GCID: GC01M201452

Cysteine And Glycine-Rich Protein 1


(Previous symbol: CYRP)
  See CSRP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteine And Glycine-Rich Protein 11 2     CRP2 3
CYRP1 2 3     CRP12 3
CSRP2 3 5     HEL-1412 3
Cysteine-Rich Protein 12 3     D1S181E2
Epididymis Luminal Protein 1412 3     LIM-Domain Protein2

External Ids:    HGNC: 24691   Entrez Gene: 14652   Ensembl: ENSG000001591767   OMIM: 1238765   UniProtKB: P212913   

Export aliases for CSRP1 gene to outside databases

Previous GC identifers: GC01M199155 GC01M196889 GC01M197919 GC01M198740 GC01M198184 GC01M199719 GC01M172618


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSRP1 Gene:
This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM
domain proteins, which may be involved in regulatory processes important for development and cellular
differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical
functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants
have been described. (provided by RefSeq, Aug 2010)

GeneCards Summary for CSRP1 Gene:
CSRP1 (cysteine and glycine-rich protein 1) is a protein-coding gene. Diseases associated with CSRP1 include pontiac fever, and endocardial fibroelastosis. An important paralog of this gene is CSRP2.

UniProtKB/Swiss-Prot: CSRP1_HUMAN, P21291
Function: Could play a role in neuronal development

Gene Wiki entry for CSRP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSRP1 gene promoter:
         USF1   GATA-3   USF2   Olf-1   USF-1:USF-2   AP-4   C/EBPalpha   CHOP-10   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CSRP1 promoter sequence
   Search Chromatin IP Primers for CSRP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSRP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

CSRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSRP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M201452:  view genomic region     (about GC identifiers)

Start:
201,452,658 bp from pter      End:
201,478,584 bp from pter
Size:
25,927 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CSRP1_HUMAN, P21291 (See protein sequence)
Recommended Name: Cysteine and glycine-rich protein 1  
Size: 193 amino acids; 20567 Da
Subunit: Monomer (By similarity)
Secondary accessions: A8K268 Q5U0J2

Explore the universe of human proteins at neXtProt for CSRP1: NX_P21291

Explore proteomics data for CSRP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CSRP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001180499.1  NP_001180500.1  NP_001180501.1  NP_004069.1  

    ENSEMBL proteins: 
     ENSP00000356275   ENSP00000432110   ENSP00000434147   ENSP00000436792   ENSP00000436491  
     ENSP00000437218   ENSP00000345079  

    CSRP1 Human Recombinant Protein Products:

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    Novus Biologicals CSRP1 Proteins
    Novus Biologicals CSRP1 Lysate
    Sino Biological Recombinant Protein for CSRP1
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CSRP1

     
    Search eBioscience for Proteins for CSRP1 

     
    antibodies-online proteins for CSRP1 (8 products) 

     
    antibodies-online peptides for CSRP1

    CSRP1 Antibody Products:

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    antibodies-online antibodies for CSRP1 (36 products) 

    CSRP1 Assay Products:

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    Cloud-Clone Corp. CLIAs for CSRP1
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    antibodies-online kits for CSRP1 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry P21291

    ProtoNet protein and cluster: P21291

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: CSRP1_HUMAN, P21291
    Similarity: Contains 2 LIM zinc-binding domains


    Find genes that share domains with CSRP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSRP1_HUMAN, P21291
    Function: Could play a role in neuronal development

         Genatlas biochemistry entry for CSRP1:
    cysteine and glycine rich protein,20.5kDa,expressed by a serum-inducible immediate response gene,likely involved
    in the determination of cell lineage and regulation of cell differentiation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CSRP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CSRP1:
     Decreased focal adhesion (FA)  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Csrp1):
     cardiovascular system  homeostasis/metabolism  muscle 

    Find genes that share phenotypes with CSRP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Csrp1tm1Mbk for CSRP1

       genOway: Develop your customized and physiologically relevant rodent model for CSRP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CSRP1:
    hsa-mir-124-3p (MIRT022790), hsa-mir-122-5p (MIRT023316), hsa-mir-1 (MIRT001373)

    Block miRNA regulation of human, mouse, rat CSRP1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CSRP1:
    hsa-miR-3934 hsa-miR-3606 hsa-miR-1245 hsa-miR-188-3p hsa-miR-921 hsa-miR-1207-5p hsa-miR-4308 hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidCSRP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CSRP1
    Predesigned siRNA for gene silencing in human, mouse, rat CSRP1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): CSRP1 (NM_001193570)
    Sino Biological Human cDNA Clone for CSRP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSRP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSRP1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for CSRP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSRP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CSRP1_HUMAN, P21291: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CSRP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CSRP1
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSRP1
    Interactions:

        GeneGlobe Interaction Network for CSRP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CSRP1 (P212913 ENSP000003450794) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTN1P128143, ENSP000003779414I2D: score=2 STRING: ENSP00000377941
    EGFRP005333, ENSP000002754934I2D: score=2 STRING: ENSP00000275493
    YWHAZP631043I2D: score=1 
    CRPENSP000002550304STRING: ENSP00000255030
    GRB2ENSP000003390074STRING: ENSP00000339007
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CSRP1

    2 Novoseek inferred chemical compound relationships for CSRP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 51.7 12 8286377 (1), 12667067 (1), 10191274 (1), 7664053 (1) (see all 8)
    zinc 48.6 6 9115265 (2), 8632452 (1), 8841116 (1), 17934856 (1)



    Find genes that share compounds with CSRP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CSRP1 gene (5 alternative transcripts): 
    NM_001193570.1  NM_001193571.1  NM_001193572.1  NM_004078.2  NM_001144773.1  

    Unigene Cluster for CSRP1:

    Cysteine and glycine-rich protein 1
    Hs.108080  [show with all ESTs]
    Unigene Representative Sequence: CR627407
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000367306(uc021phg.1 uc021phh.1 uc001gws.3 uc010ppr.2)
    ENST00000533402 ENST00000527662(uc001gwr.2) ENST00000532313 ENST00000531916
    ENST00000532460 ENST00000526256 ENST00000533432 ENST00000530120 ENST00000526723
    ENST00000526317 ENST00000524951 ENST00000458271(uc010pps.2) ENST00000527573
    ENST00000529975 ENST00000533188 ENST00000471596 ENST00000481851
    miRNA
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    Block miRNA regulation of human, mouse, rat CSRP1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CSRP1:
    hsa-miR-3934 hsa-miR-3606 hsa-miR-1245 hsa-miR-188-3p hsa-miR-921 hsa-miR-1207-5p hsa-miR-4308 hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidCSRP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CSRP1
    Predesigned siRNA for gene silencing in human, mouse, rat CSRP1
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    OriGene clones in human, mouse for CSRP1 (see all 16)
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    GenScript: all cDNA clones in your preferred vector (see all 4): CSRP1 (NM_001193570)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSRP1
    Primer
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    OriGene qPCR primer pairs and template standards for CSRP1
    OriGene qSTAR qPCR primer pairs in human, mouse for CSRP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSRP1
      QuantiTect SYBR Green Assays in human, mouse, rat CSRP1
      QuantiFast Probe-based Assays in human, mouse, rat CSRP1

    Additional mRNA sequence: 

    AB209756.1 AK057876.1 AK122812.1 AK126445.1 AK126507.1 AK290133.1 AK293053.1 AK302237.1 
    AK304415.1 BC004265.1 BC007492.2 BC018806.1 BC032493.1 BT019520.1 BX537488.1 BX641046.1 
    CR627407.1 M33146.1 

    Selected DOTS entries (see all 36):

    DT.95107072  DT.100879890  DT.40189536  DT.100879897  DT.91717746  DT.100646778  DT.97836273  DT.95249407 
    DT.101985493  DT.100879896  DT.101985492  DT.100879879  DT.95087014  DT.100879888  DT.100032992  DT.95217240 
    DT.121461440  DT.121461475  DT.100879887  DT.100879889  DT.92468624  DT.97858197  DT.100759569  DT.100835566 

    Selected AceView cDNA sequences (see all 967):

    AL602874 BP341667 CB267283 BU507571 BM759183 BQ680289 CR614180 BP374061 
    CR601068 H50329 BQ772489 BP341167 CB216804 BP373128 BP374347 AL560715 
    BP374614 AL556026 BP342020 CR613755 BP338400 BP372060 CR595754 BQ691957 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CSRP1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ·
    SP1:                          -                                                                       -     -     -     -                                       
    SP2:                          -                                                                 -     -     -     -     -                                       
    SP3:                          -     -                                                                 -     -     -     -                                       
    SP4:                          -                                         -     -                       -     -     -     -                                       
    SP5:                          -                       -     -                                         -     -     -     -                                       

    ExUns: 8f ^ 9a · 9b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for CSRP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSRP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGTACCC
    CSRP1 Expression
    About this image


    CSRP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 31) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Metanephros
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
    CSRP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSRP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.108080
        Custom PCR Arrays for CSRP1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSRP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CSRP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csrp11 , 5 cysteine and glycine-rich protein 11, 5 90.85(n)1
    99.48(a)1
      1 (59.23 cM)5
    130071  NM_007791.51  NP_031817.11 
     1357200615 
    chicken
    (Gallus gallus)
    Aves CSRP11 cysteine and glycine-rich protein 1 81.94(n)
    90.62(a)
      396176  NM_205248.1  NP_990579.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSRP16
    cysteine and glycine-rich protein 1
    89(a)
    1 ↔ 1
    4(131542858-131576325)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia csrp11 cysteine and glycine-rich protein 1 72.54(n)
    81.35(a)
      448688  NM_001006880.2  NP_001006881.1 
    zebrafish
    (Danio rerio)
    Actinopterygii csrp12 cysteine and glycine-rich protein 1 75.67(n)   378726  CK026064.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlp84B3 cell differentiation 48(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea mlp-16
    Protein MLP-1, isoform a
    48(a)
    1 → many
    III(5971530-5973664) WBGene00003375


    ENSEMBL Gene Tree for CSRP1 (if available)
    TreeFam Gene Tree for CSRP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSRP1 gene
    CSRP22  CRIP22  CRIP32  ENSG000002573412  CRIP12  CSRP32  
    10 SIMAP similar genes for CSRP1 using alignment to 4 protein entries:     CSRP1_HUMAN (see all proteins):
    DKFZp686M148    DKFZp686P2249    CSRP3    CSRP2    AJUBA    CRIP1
    CRIP3    LHX8    CRIP2    LIMS2

    Find genes that share paralogs with CSRP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSRP1 (see all 594)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106768301,2
    C--172637168(+) ATAAA-/TAAA/ 
    TAAATAAA
    GTCTG
    3 -- int10--------
    rs5865071,2
    C,F,A,H--201452356(-) ACAAAC/TGTGAA 4 -- ds500115Minor allele frequency- T:0.15NA WA CSA EA 381
    rs4948381,2
    C,F,A,H--201452473(-) GGTGGT/CGGGTG 4 -- ds500112Minor allele frequency- C:0.31MN NA WA CSA 572
    rs10536351,2
    C,H--201452906(-) AGAATC/TTTCCC 4 -- ut31 trp37Minor allele frequency- T:0.02MN NS EA NA 604
    rs562427491,2
    C--201453022(+) CTGGGC/ATCTGC 4 -- ut312Minor allele frequency- A:0.09WA 120
    rs1867361591,2
    --201453063(+) CCAGAC/GATAAA 4 -- ut310--------
    rs1911787491,2
    --201453079(+) ATTTGA/GGCCAT 4 -- ut310--------
    rs5766971,2
    C,F,A,H--201453289(+) GACCCC/G/TGCCTG 8 -- ut31 ese321EA NA WA CSA 1987
    rs1382570591,2
    --201453314(+) TCCAAC/TAGTGA 4 -- ut310--------
    rs1412146021,2
    --201453407(+) ATCCAA/GAAAAC 4 -- ut310--------

    HapMap Linkage Disequilibrium report for CSRP1 (201452658 - 201478584 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CSRP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832315CNV Loss17160897
    nsv467961CNV Gain19166990
    nsv470776CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSRP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CSRP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123876    OMIM disorders: --

    2 diseases for CSRP1:    
    About MalaCards
    pontiac fever    endocardial fibroelastosis


    Find genes that share disorders with CSRP1           About GenesLikeMe

    2 Novoseek inferred disease relationships for CSRP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sepsis 7.75 4 10208949 (1), 17691022 (1), 10452048 (1)
    tumors 4.94 1 11119586 (1)

    Genetic Association Database (GAD): CSRP1
    Human Genome Epidemiology (HuGE) Navigator: CSRP1 (1 document)

    Export disorders for CSRP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSRP1 gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with CSRP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif. (PubMed id 2115670)1, 2, 3 Liebhaber S.A.... Cooke N.E. (Nucleic Acids Res. 1990)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization. (PubMed id 9925910)1, 3 Erdel M. and Weiskirchen R. (Cytogenet. Cell Genet. 1998)
    8. Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc. (PubMed id 1374386)1, 2 Wang X.... Cooke N.E. (J. Biol. Chem. 1992)
    9. Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes. (PubMed id 20415737)1, 9 Latonen L....Laiho M. (amp 2010)
    10. Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma. (PubMed id 17341888)1, 9 Hirasawa Y....Yokosuka O. (Oncology 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1465 HGNC: 2469 AceView: CSRP1 Ensembl:ENSG00000159176 euGenes: HUgn1465
    ECgene: CSRP1 H-InvDB: CSRP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CSRP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CSRP1 gene:
    Search GeneIP for patents involving CSRP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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