Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CSRP1 Gene

Aliases for CSRP1 Gene

  • Cysteine And Glycine Rich Protein 1 2 3 5
  • Epididymis Luminal Protein 141 3 4
  • Cysteine-Rich Protein 1 3 4
  • HEL-141 3 4
  • CRP1 3 4
  • CYRP 3 4
  • CSRP 3 4
  • CRP 3 4
  • Cysteine And Glycine-Rich Protein 1 3
  • Epididymis Secretory Protein Li 286 3
  • LIM-Domain Protein 3
  • HEL-S-286 3
  • D1S181E 3

External Ids for CSRP1 Gene

Previous HGNC Symbols for CSRP1 Gene

  • CYRP

Previous GeneCards Identifiers for CSRP1 Gene

  • GC01M199155
  • GC01M196889
  • GC01M197919
  • GC01M198740
  • GC01M198184
  • GC01M199719
  • GC01M172618

Summaries for CSRP1 Gene

Entrez Gene Summary for CSRP1 Gene

  • This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

GeneCards Summary for CSRP1 Gene

CSRP1 (Cysteine And Glycine Rich Protein 1) is a Protein Coding gene. Diseases associated with CSRP1 include Pontiac Fever. Among its related pathways are MECP2 and Associated Rett Syndrome. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is CSRP2.

UniProtKB/Swiss-Prot for CSRP1 Gene

  • Could play a role in neuronal development.

Gene Wiki entry for CSRP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRP1 Gene

Genomics for CSRP1 Gene

Regulatory Elements for CSRP1 Gene

Enhancers for CSRP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G201530 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -22.0 -22012 2.8 PKNOX1 FOXA2 ATF1 ZNF493 ZFP64 SIN3A ZNF2 YY1 ZNF121 GLIS2 IPO9-AS1 NAV1 IPO9 ENSG00000235121 ENSG00000224536 CSRP1 PHLDA3 ENSG00000224818 ELF3-AS1 RNU6-501P
GH01G201474 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +33.1 33101 3.1 ATF1 RB1 ZNF121 SCRT2 RCOR1 RELB IKZF2 CREM DEK EGR2 ENSG00000224818 CSRP1 ENSG00000224536 NAV1 GC01P201469 GC01M201488
GH01G201709 2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -203.9 -203886 8.7 HDGF PKNOX1 SIN3A ZNF2 ZBTB7B ZNF143 ZNF548 FOS DEK SP3 IPO9 NAV1 IPO9-AS1 MIR1231 RPS27P8 ENSG00000236390 CSRP1 ENSG00000224536 PHLDA3 ENSG00000224818
GH01G201769 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -260.8 -260830 1.7 CTCF HDGF GTF2F1 MXI1 NFIB SIN3A RBBP5 RAD21 MTA3 ZFHX2 ENSG00000224536 NAV1 CSRP1 ENSG00000235121 RNU6-501P ENSG00000236390 SHISA4 MIR1231
GH01G201772 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -264.5 -264516 3.9 PKNOX1 ZFP64 GATA2 ZSCAN5C FOS RCOR1 ZNF202 ZNF426 ZNF623 ZNF781 ENSG00000235121 IPO9-AS1 IPO9 NAV1 MIR1231 RNU6-501P CSRP1 ENSG00000236390 ENSG00000224536
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CSRP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CSRP1 Gene

Chromosome:
1
Start:
201,483,530 bp from pter
End:
201,509,456 bp from pter
Size:
25,927 bases
Orientation:
Minus strand

Genomic View for CSRP1 Gene

Genes around CSRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRP1 Gene

Proteins for CSRP1 Gene

  • Protein details for CSRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21291-CSRP1_HUMAN
    Recommended name:
    Cysteine and glycine-rich protein 1
    Protein Accession:
    P21291
    Secondary Accessions:
    • A8K268
    • Q5U0J2

    Protein attributes for CSRP1 Gene

    Size:
    193 amino acids
    Molecular mass:
    20567 Da
    Quaternary structure:
    • Interacts with ASCC1; ASCC2 AND TRIP4.

neXtProt entry for CSRP1 Gene

Post-translational modifications for CSRP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for CSRP1

No data available for DME Specific Peptides for CSRP1 Gene

Domains & Families for CSRP1 Gene

Gene Families for CSRP1 Gene

Protein Domains for CSRP1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CSRP1: view

No data available for UniProtKB/Swiss-Prot for CSRP1 Gene

Function for CSRP1 Gene

Molecular function for CSRP1 Gene

GENATLAS Biochemistry:
cysteine and glycine rich protein,20.5kDa,expressed by a serum-inducible immediate response gene,likely involved in the determination of cell lineage and regulation of cell differentiation
UniProtKB/Swiss-Prot Function:
Could play a role in neuronal development.

Gene Ontology (GO) - Molecular Function for CSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0008270 zinc ion binding TAS 1374386
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CSRP1: view
genes like me logo Genes that share phenotypes with CSRP1: view

Animal Models for CSRP1 Gene

MGI Knock Outs for CSRP1:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSRP1 Gene

Localization for CSRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSRP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 26924529
GO:0005925 focal adhesion IDA 21423176
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CSRP1: view

Pathways & Interactions for CSRP1 Gene

genes like me logo Genes that share pathways with CSRP1: view

Pathways by source for CSRP1 Gene

1 BioSystems pathway for CSRP1 Gene

Gene Ontology (GO) - Biological Process for CSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070527 platelet aggregation IMP 23382103
genes like me logo Genes that share ontologies with CSRP1: view

No data available for SIGNOR curated interactions for CSRP1 Gene

Drugs & Compounds for CSRP1 Gene

(2) Drugs for CSRP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CSRP1: view

Transcripts for CSRP1 Gene

Unigene Clusters for CSRP1 Gene

Cysteine and glycine-rich protein 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSRP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - -
SP9: - -
SP10: - - - - - - - - - - - -
SP11: -
SP12: - - - - - - - - - - - -
SP13: - - - - -
SP14:

ExUns: 8f ^ 9a · 9b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for CSRP1 Gene

GeneLoc Exon Structure for
CSRP1
ECgene alternative splicing isoforms for
CSRP1

Expression for CSRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSRP1 Gene

mRNA differential expression in normal tissues according to GTEx for CSRP1 Gene

This gene is overexpressed in Colon - Sigmoid (x4.8), Artery - Tibial (x4.5), and Esophagus - Muscularis (x4.0).

Protein differential expression in normal tissues from HIPED for CSRP1 Gene

This gene is overexpressed in Prostate (8.9), Cardia (8.4), Urinary Bladder (7.9), and Colon muscle (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSRP1 Gene



Protein tissue co-expression partners for CSRP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CSRP1 Gene:

CSRP1

SOURCE GeneReport for Unigene cluster for CSRP1 Gene:

Hs.108080

Evidence on tissue expression from TISSUES for CSRP1 Gene

  • Nervous system(5)
  • Intestine(4.6)
  • Liver(4.3)
  • Lung(3.8)
  • Stomach(3.8)
  • Kidney(3.7)
  • Skin(3.5)
  • Muscle(2.5)
  • Eye(2.2)
  • Gall bladder(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with CSRP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSRP1 Gene

Orthologs for CSRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSRP1 34 35
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia CSRP1 35
  • 97 (a)
OneToOne
LOC607054 34
  • 91.36 (n)
mouse
(Mus musculus)
Mammalia Csrp1 34 16 35
  • 90.85 (n)
cow
(Bos Taurus)
Mammalia CSRP1 34 35
  • 90.33 (n)
rat
(Rattus norvegicus)
Mammalia Csrp1 34
  • 89.29 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CSRP1 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSRP1 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves CSRP1 34 35
  • 81.94 (n)
lizard
(Anolis carolinensis)
Reptilia CSRP1 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csrp1 34
  • 72.54 (n)
zebrafish
(Danio rerio)
Actinopterygii csrp1b 35
  • 82 (a)
OneToMany
csrp1a 34 35
  • 74.13 (n)
csrp1 34
fruit fly
(Drosophila melanogaster)
Insecta Mlp84B 36 35
  • 48 (a)
Mlp60A 35
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea mlp-1 35
  • 48 (a)
OneToMany
Species where no ortholog for CSRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRP1 Gene

ENSEMBL:
Gene Tree for CSRP1 (if available)
TreeFam:
Gene Tree for CSRP1 (if available)

Paralogs for CSRP1 Gene

Paralogs for CSRP1 Gene

(10) SIMAP similar genes for CSRP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CSRP1: view

Variants for CSRP1 Gene

Sequence variations from dbSNP and Humsavar for CSRP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000037925 -- 201,492,219(+) GTGTA(C/T)TTTGG intron-variant
rs1000091437 -- 201,500,439(+) TGGGT(A/G)AAACC intron-variant
rs1000106423 -- 201,486,128(+) CAGGA(G/T)AATCC intron-variant
rs1000191763 -- 201,494,026(+) CACTG(A/G)CCCTG intron-variant
rs1000388937 -- 201,491,948(+) CTAAA(C/T)AAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSRP1 Gene

Variant ID Type Subtype PubMed ID
esv3578371 CNV loss 25503493
nsv1009060 CNV gain 25217958
nsv1145393 CNV deletion 24896259
nsv467961 CNV gain 19166990
nsv470776 CNV gain 18288195
nsv548997 CNV gain 21841781
nsv832315 CNV loss 17160897
nsv947466 CNV duplication 23825009

Variation tolerance for CSRP1 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSRP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSRP1 Gene

Disorders for CSRP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CSRP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
pontiac fever
- elite association - COSMIC cancer census association via MalaCards
Search CSRP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CSRP1

Genetic Association Database (GAD)
CSRP1
Human Genome Epidemiology (HuGE) Navigator
CSRP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSRP1
genes like me logo Genes that share disorders with CSRP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSRP1 Gene

Publications for CSRP1 Gene

  1. Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif. (PMID: 2115670) Liebhaber S.A. … Cooke N.E. (Nucleic Acids Res. 1990) 2 3 4 64
  2. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. (PMID: 26924529) Knierim E. … Schuelke M. (Am. J. Hum. Genet. 2016) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes. (PMID: 20415737) Latonen L. … Laiho M. (Photodermatol Photoimmunol Photomed 2010) 3 22 64
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64

Products for CSRP1 Gene

Sources for CSRP1 Gene

Content
Loading form....