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Aliases for CSRNP3 Gene

Aliases for CSRNP3 Gene

  • Cysteine And Serine Rich Nuclear Protein 3 2 3
  • Cysteine-Serine-Rich Nuclear Protein 3 2 3 5
  • Family With Sequence Similarity 130, Member A2 2 3
  • TGF-Beta-Induced Apoptosis Protein 2 3 4
  • TGF Beta Induced Apotosis Protein 2 2 3
  • FAM130A2 3 4
  • CSRNP-3 3 4
  • TAIP-2 3 4
  • TAIP2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 73 3
  • TGF-Beta Induced Apoptosis Protein 2 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 73 2
  • Protein FAM130A2 4
  • PPP1R73 3

External Ids for CSRNP3 Gene

Previous HGNC Symbols for CSRNP3 Gene

  • FAM130A2

Previous GeneCards Identifiers for CSRNP3 Gene

  • GC02P166036
  • GC02P166138
  • GC02P166326
  • GC02P158208

Summaries for CSRNP3 Gene

GeneCards Summary for CSRNP3 Gene

CSRNP3 (Cysteine And Serine Rich Nuclear Protein 3) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. An important paralog of this gene is CSRNP2.

UniProtKB/Swiss-Prot for CSRNP3 Gene

  • Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity. Plays a role in apoptosis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRNP3 Gene

Genomics for CSRNP3 Gene

Regulatory Elements for CSRNP3 Gene

Enhancers for CSRNP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CSRNP3 on UCSC Golden Path with GeneCards custom track

Promoters for CSRNP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CSRNP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CSRNP3 Gene

165,469,647 bp from pter
165,689,407 bp from pter
219,761 bases
Plus strand

Genomic View for CSRNP3 Gene

Genes around CSRNP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSRNP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSRNP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRNP3 Gene

Proteins for CSRNP3 Gene

  • Protein details for CSRNP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine/serine-rich nuclear protein 3
    Protein Accession:
    Secondary Accessions:
    • B3KPR4
    • Q53SG0
    • Q6ZTX3
    • Q9HAF9

    Protein attributes for CSRNP3 Gene

    585 amino acids
    Molecular mass:
    64900 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB13890.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86454.1; Type=Frameshift; Positions=180; Evidence={ECO:0000305}; Sequence=BAC86454.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Alternative splice isoforms for CSRNP3 Gene


neXtProt entry for CSRNP3 Gene

Proteomics data for CSRNP3 Gene at MOPED

Post-translational modifications for CSRNP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSRNP3 Gene

No data available for DME Specific Peptides for CSRNP3 Gene

Domains & Families for CSRNP3 Gene

Gene Families for CSRNP3 Gene

Protein Domains for CSRNP3 Gene


Suggested Antigen Peptide Sequences for CSRNP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AXUD1 family.
  • Belongs to the AXUD1 family.
genes like me logo Genes that share domains with CSRNP3: view

Function for CSRNP3 Gene

Molecular function for CSRNP3 Gene

UniProtKB/Swiss-Prot Function:
Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity. Plays a role in apoptosis (By similarity).

Gene Ontology (GO) - Molecular Function for CSRNP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,ISS 17726538
genes like me logo Genes that share ontologies with CSRNP3: view
genes like me logo Genes that share phenotypes with CSRNP3: view

Animal Models for CSRNP3 Gene

MGI Knock Outs for CSRNP3:

Animal Model Products

miRNA for CSRNP3 Gene

miRTarBase miRNAs that target CSRNP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSRNP3 Gene

Localization for CSRNP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRNP3 Gene

Subcellular locations from

Jensen Localization Image for CSRNP3 Gene COMPARTMENTS Subcellular localization image for CSRNP3 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for CSRNP3 Gene

Pathways & Interactions for CSRNP3 Gene

SuperPathways for CSRNP3 Gene

No Data Available

Interacting Proteins for CSRNP3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000318258 for CSRNP3 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CSRNP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with CSRNP3: view

No data available for Pathways by source and SIGNOR curated interactions for CSRNP3 Gene

Drugs & Compounds for CSRNP3 Gene

(1) Drugs for CSRNP3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bisphosphonates Pharma 0
genes like me logo Genes that share compounds with CSRNP3: view

Transcripts for CSRNP3 Gene

mRNA/cDNA for CSRNP3 Gene

Unigene Clusters for CSRNP3 Gene

Cysteine-serine-rich nuclear protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSRNP3 Gene

No ASD Table

Relevant External Links for CSRNP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CSRNP3 Gene

mRNA expression in normal human tissues for CSRNP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSRNP3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.3), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Nucleus accumbens (basal ganglia) (x4.3).

SOURCE GeneReport for Unigene cluster for CSRNP3 Gene Hs.470479

genes like me logo Genes that share expression patterns with CSRNP3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CSRNP3 Gene

Orthologs for CSRNP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRNP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CSRNP3 35
  • 89.83 (n)
  • 98.31 (a)
  • 87 (a)
(Canis familiaris)
Mammalia CSRNP3 35
  • 81.01 (n)
  • 85.87 (a)
  • 76 (a)
(Mus musculus)
Mammalia Csrnp3 35
  • 86.51 (n)
  • 94 (a)
Csrnp3 16
Csrnp3 36
  • 92 (a)
(Pan troglodytes)
Mammalia CSRNP3 35
  • 99.32 (n)
  • 99.32 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Csrnp3 35
  • 86.22 (n)
  • 93.65 (a)
(Monodelphis domestica)
Mammalia CSRNP3 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia CSRNP3 36
  • 87 (a)
(Gallus gallus)
Aves CSRNP3 35
  • 80.67 (n)
  • 86.4 (a)
  • 85 (a)
(Anolis carolinensis)
Reptilia CSRNP3 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia csrnp3 35
  • 72.38 (n)
  • 74.57 (a)
(Danio rerio)
Actinopterygii -- 35
LOC100332048 35
  • 64.83 (n)
  • 61.65 (a)
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Axud1 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea C41D11.3 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7164 36
  • 25 (a)
Species with no ortholog for CSRNP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRNP3 Gene

Gene Tree for CSRNP3 (if available)
Gene Tree for CSRNP3 (if available)

Paralogs for CSRNP3 Gene

Paralogs for CSRNP3 Gene

(2) SIMAP similar genes for CSRNP3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CSRNP3: view

Variants for CSRNP3 Gene

Sequence variations from dbSNP and Humsavar for CSRNP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035993 A colorectal cancer sample
rs699483 -- 165,686,186(+) AATGT(C/T)TCTTT utr-variant-3-prime
rs1551336 -- 165,603,969(+) GGGCT(C/T)TCAAA intron-variant
rs1551337 -- 165,604,079(+) ATGGA(C/T)ATTTA intron-variant
rs751371 -- 165,676,824(-) TATAT(C/G)TTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSRNP3 Gene

Variant ID Type Subtype PubMed ID
esv2721070 CNV Deletion 23290073
esv272128 CNV Insertion 20981092
nsv875371 CNV Gain 21882294
nsv3016 CNV Insertion 18451855
esv4871 CNV Deletion 18987735
esv2721071 CNV Deletion 23290073
esv2721072 CNV Deletion 23290073
esv2721074 CNV Deletion 23290073
esv2721075 CNV Deletion 23290073
nsv3017 CNV Loss 18451855

Variation tolerance for CSRNP3 Gene

Residual Variation Intolerance Score: 21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CSRNP3 Gene

Disorders for CSRNP3 Gene

Relevant External Links for CSRNP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CSRNP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSRNP3 Gene

Publications for CSRNP3 Gene

  1. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick D.M. … Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48 67
  2. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). (PMID: 17726538) Gingras S. … Ihle J.N. (PLoS ONE 2007) 2 3
  3. Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. (PMID: 24688116) Deelen J. … Slagboom P.E. (Hum. Mol. Genet. 2014) 3
  4. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3
  5. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A. … Bollen M. (Chem. Biol. 2009) 3

Products for CSRNP3 Gene

Sources for CSRNP3 Gene