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Aliases for CSRNP3 Gene

Aliases for CSRNP3 Gene

  • Cysteine-Serine-Rich Nuclear Protein 3 2 3
  • Family With Sequence Similarity 130, Member A2 2 3
  • TGF-Beta-Induced Apoptosis Protein 2 3 4
  • TGF Beta Induced Apotosis Protein 2 2 3
  • FAM130A2 3 4
  • CSRNP-3 3 4
  • TAIP-2 3 4
  • TAIP2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 73 3
  • Cysteine/Serine-Rich Nuclear Protein 3 3
  • TGF-Beta Induced Apoptosis Protein 2 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 73 2
  • Protein FAM130A2 4
  • PPP1R73 3

External Ids for CSRNP3 Gene

Previous HGNC Symbols for CSRNP3 Gene

  • FAM130A2

Previous GeneCards Identifiers for CSRNP3 Gene

  • GC02P166036
  • GC02P166138
  • GC02P166326
  • GC02P158208

Summaries for CSRNP3 Gene

GeneCards Summary for CSRNP3 Gene

CSRNP3 (Cysteine-Serine-Rich Nuclear Protein 3) is a Protein Coding gene. Diseases associated with CSRNP3 include leopard syndrome. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CSRNP2.

UniProtKB/Swiss-Prot for CSRNP3 Gene

  • Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity. Plays a role in apoptosis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRNP3 Gene

Genomics for CSRNP3 Gene

Regulatory Elements for CSRNP3 Gene

Genomic Location for CSRNP3 Gene

Start:
165,469,647 bp from pter
End:
165,689,407 bp from pter
Size:
219,761 bases
Orientation:
Plus strand

Genomic View for CSRNP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSRNP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRNP3 Gene

Proteins for CSRNP3 Gene

  • Protein details for CSRNP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYN3-CSRN3_HUMAN
    Recommended name:
    Cysteine/serine-rich nuclear protein 3
    Protein Accession:
    Q8WYN3
    Secondary Accessions:
    • B3KPR4
    • Q53SG0
    • Q6ZTX3
    • Q9HAF9

    Protein attributes for CSRNP3 Gene

    Size:
    585 amino acids
    Molecular mass:
    64900 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13890.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86454.1; Type=Frameshift; Positions=180; Evidence={ECO:0000305}; Sequence=BAC86454.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Alternative splice isoforms for CSRNP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSRNP3 Gene

Proteomics data for CSRNP3 Gene at MOPED

Post-translational modifications for CSRNP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSRNP3 Gene

No data available for DME Specific Peptides for CSRNP3 Gene

Domains for CSRNP3 Gene

Gene Families for CSRNP3 Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for CSRNP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CSRNP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYN3

UniProtKB/Swiss-Prot:

CSRN3_HUMAN :
  • Q8WYN3
Family:
  • Belongs to the AXUD1 family.
genes like me logo Genes that share domains with CSRNP3: view

Function for CSRNP3 Gene

Molecular function for CSRNP3 Gene

UniProtKB/Swiss-Prot Function: Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity. Plays a role in apoptosis (By similarity).

Gene Ontology (GO) - Molecular Function for CSRNP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity ISS 17726538
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CSRNP3: view
genes like me logo Genes that share phenotypes with CSRNP3: view

Animal Models for CSRNP3 Gene

MGI Knock Outs for CSRNP3:

Animal Model Products

CRISPR Products

miRNA for CSRNP3 Gene

miRTarBase miRNAs that target CSRNP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSRNP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CSRNP3 Gene

Localization for CSRNP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRNP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSRNP3 Gene COMPARTMENTS Subcellular localization image for CSRNP3 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for CSRNP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 17726538
genes like me logo Genes that share ontologies with CSRNP3: view

Pathways for CSRNP3 Gene

SuperPathways for CSRNP3 Gene

No Data Available

Interacting Proteins for CSRNP3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000318258%0d%0a9606.ENSP00000326031%0d%0a
Selected Interacting proteins: ENSP00000318258 for CSRNP3 Gene via STRING

Symbol External ID(s) Details
PPP1CA

Gene Ontology (GO) - Biological Process for CSRNP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0043065 positive regulation of apoptotic process ISS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS 17726538
genes like me logo Genes that share ontologies with CSRNP3: view

No data available for Pathways by source for CSRNP3 Gene

Compounds for CSRNP3 Gene

(1) PharmGKB related drug/compound annotations for CSRNP3 Gene

Drug/compound Annotation
Bisphosphonates CA
genes like me logo Genes that share compounds with CSRNP3: view

Transcripts for CSRNP3 Gene

mRNA/cDNA for CSRNP3 Gene

Unigene Clusters for CSRNP3 Gene

Cysteine-serine-rich nuclear protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSRNP3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CSRNP3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSRNP3 Gene

No ASD Table

Relevant External Links for CSRNP3 Gene

GeneLoc Exon Structure for
CSRNP3
ECgene alternative splicing isoforms for
CSRNP3

Expression for CSRNP3 Gene

mRNA expression in normal human tissues for CSRNP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSRNP3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.3), Brain - Anterior cingulate cortex (BA24) (4.8), and Brain - Nucleus accumbens (basal ganglia) (4.3).

SOURCE GeneReport for Unigene cluster for CSRNP3 Gene Hs.470479

genes like me logo Genes that share expressions with CSRNP3: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for CSRNP3 Gene

Orthologs for CSRNP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRNP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSRNP3 35
  • 99.32 (n)
  • 99.32 (a)
CSRNP3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSRNP3 35
  • 89.83 (n)
  • 98.31 (a)
CSRNP3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSRNP3 35
  • 81.01 (n)
  • 85.87 (a)
CSRNP3 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csrnp3 35
  • 86.51 (n)
  • 94 (a)
Csrnp3 16
Csrnp3 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSRNP3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSRNP3 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csrnp3 35
  • 86.22 (n)
  • 93.65 (a)
chicken
(Gallus gallus)
Aves CSRNP3 35
  • 80.67 (n)
  • 86.4 (a)
CSRNP3 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSRNP3 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csrnp3 35
  • 72.38 (n)
  • 74.57 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
CSRNP3 36
  • 58 (a)
OneToOne
LOC100332048 35
  • 64.83 (n)
  • 61.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta Axud1 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C41D11.3 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7164 36
  • 25 (a)
OneToMany
Species with no ortholog for CSRNP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRNP3 Gene

ENSEMBL:
Gene Tree for CSRNP3 (if available)
TreeFam:
Gene Tree for CSRNP3 (if available)

Paralogs for CSRNP3 Gene

Paralogs for CSRNP3 Gene

Selected SIMAP similar genes for CSRNP3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CSRNP3: view

Variants for CSRNP3 Gene

Sequence variations from dbSNP and Humsavar for CSRNP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs699483 -- 165,686,186(+) AATGT(C/T)TCTTT utr-variant-3-prime
rs729867 -- 165,629,810(+) CCTGC(C/T)TTTTT intron-variant
rs729868 -- 165,629,845(+) ATTTG(G/T)CTTCA intron-variant
rs729869 -- 165,629,846(+) TTTGT(C/T)TTCAT intron-variant
rs751371 -- 165,676,824(-) TATAT(C/G)TTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSRNP3 Gene

Variant ID Type Subtype PubMed ID
esv2721070 CNV Deletion 23290073
esv272128 CNV Insertion 20981092
nsv875371 CNV Gain 21882294
nsv3016 CNV Insertion 18451855
esv4871 CNV Deletion 18987735
esv2721071 CNV Deletion 23290073
esv2721072 CNV Deletion 23290073
esv2721074 CNV Deletion 23290073
esv2721075 CNV Deletion 23290073
nsv3017 CNV Loss 18451855

Relevant External Links for CSRNP3 Gene

HapMap Linkage Disequilibrium report
CSRNP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSRNP3 Gene

Disorders for CSRNP3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CSRNP3 Gene including...

Search for CSRNP3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CSRNP3 Gene

Relevant External Links for CSRNP3

Genetic Association Database (GAD)
CSRNP3
Human Genome Epidemiology (HuGE) Navigator
CSRNP3
genes like me logo Genes that share disorders with CSRNP3: view

No data available for UniProtKB/Swiss-Prot for CSRNP3 Gene

Publications for CSRNP3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). (PMID: 17726538) Gingras S. … Ihle J.N. (PLoS ONE 2007) 2 3
  4. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3 48
  5. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick D.M. … Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48

Products for CSRNP3 Gene

Sources for CSRNP3 Gene

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