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Aliases for CSRNP2 Gene

Aliases for CSRNP2 Gene

  • Cysteine-Serine-Rich Nuclear Protein 2 2 3
  • Family With Sequence Similarity 130, Member A1 2 3
  • TGF-Beta-Induced Apoptosis Protein 12 3 4
  • C12orf22 3 4
  • FAM130A1 3 4
  • CSRNP-2 3 4
  • TAIP-12 3 4
  • Protein Phosphatase 1, Regulatory Subunit 72 3
  • Cysteine/Serine-Rich Nuclear Protein 2 3
  • Chromosome 12 Open Reading Frame 22 2
  • Protein Phosphatase 1 2
  • Regulatory Subunit 72 2
  • Protein FAM130A1 4
  • C12orf2 3
  • PPP1R72 3
  • TAIP12 4

External Ids for CSRNP2 Gene

Previous Symbols for CSRNP2 Gene

  • C12orf22
  • FAM130A1

Summaries for CSRNP2 Gene

Entrez Gene Summary for CSRNP2 Gene

  • The protein encoded by this gene belongs to the CSRNP family of nuclear proteins that share conserved regions, including cysteine- and serine- rich regions, a basic domain, a transcriptional activation domain, and bind the sequence 'AGAGTG', thus have the hallmark of transcription factors. Studies in mice suggest that these genes may have redundant functions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CSRNP2 Gene

CSRNP2 (Cysteine-Serine-Rich Nuclear Protein 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and phosphatase binding. An important paralog of this gene is CSRNP3.

UniProtKB/Swiss-Prot for CSRNP2 Gene

  • Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity (By similarity). May play a role in apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRNP2 Gene

Genomics for CSRNP2 Gene

Genomic Location for CSRNP2 Gene

51,061,205 bp from pter
51,083,671 bp from pter
22,467 bases
Minus strand

Genomic View for CSRNP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSRNP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRNP2 Gene

Regulatory Elements for CSRNP2 Gene

Proteins for CSRNP2 Gene

  • Protein details for CSRNP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine/serine-rich nuclear protein 2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CSRNP2 Gene

    543 amino acids
    Molecular mass:
    59591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CSRNP2 Gene

Proteomics data for CSRNP2 Gene at MOPED

Post-translational modifications for CSRNP2 Gene

No Post-translational modifications

Other Protein References for CSRNP2 Gene

No data available for DME Specific Peptides for CSRNP2 Gene

Domains for CSRNP2 Gene

Gene Families for CSRNP2 Gene

  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for CSRNP2 Gene



  • Belongs to the AXUD1 family.:
    • Q9H175
genes like me logo Genes that share domains with CSRNP2: view

Function for CSRNP2 Gene

Molecular function for CSRNP2 Gene

UniProtKB/Swiss-Prot Function: Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity (By similarity). May play a role in apoptosis.

Gene Ontology (GO) - Molecular Function for CSRNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity ISS 17726538
GO:0005515 protein binding IPI 15231748
GO:0019902 phosphatase binding IDA 19389623
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CSRNP2: view
genes like me logo Genes that share phenotypes with CSRNP2: view

Animal Models for CSRNP2 Gene

MGI Knock Outs for CSRNP2:

miRNA for CSRNP2 Gene

miRTarBase miRNAs that target CSRNP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CSRNP2 Gene

Localization for CSRNP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRNP2 Gene

Subcellular locations from

Jensen Localization Image for CSRNP2 Gene COMPARTMENTS Subcellular localization image for CSRNP2 gene
Compartment Confidence
nucleus 5
chloroplast 2
cytosol 2

Gene Ontology (GO) - Cellular Components for CSRNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 17726538
genes like me logo Genes that share ontologies with CSRNP2: view

Pathways for CSRNP2 Gene

SuperPathways for CSRNP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CSRNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS 17726538
genes like me logo Genes that share ontologies with CSRNP2: view

No data available for Pathways by source for CSRNP2 Gene

Transcripts for CSRNP2 Gene

Unigene Clusters for CSRNP2 Gene

Cysteine-serine-rich nuclear protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSRNP2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - -
SP5: - - - - -
SP6: - -
SP7: -

Relevant External Links for CSRNP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CSRNP2 Gene

mRNA expression in normal human tissues for CSRNP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CSRNP2 Gene

SOURCE GeneReport for Unigene cluster for CSRNP2 Gene Hs.524425

genes like me logo Genes that share expressions with CSRNP2: view

Orthologs for CSRNP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRNP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CSRNP2 36
  • 99.69 (n)
  • 99.63 (a)
  • 100 (a)
(Bos Taurus)
Mammalia CSRNP2 36
  • 90.48 (n)
  • 93.37 (a)
  • 90 (a)
(Canis familiaris)
Mammalia CSRNP2 36
  • 90.06 (n)
  • 93.92 (a)
  • 92 (a)
(Mus musculus)
Mammalia Csrnp2 36
  • 86.45 (n)
  • 92.32 (a)
Csrnp2 16
Csrnp2 37
  • 91 (a)
(Rattus norvegicus)
Mammalia Csrnp2 36
  • 86.54 (n)
  • 92.71 (a)
(Gallus gallus)
Aves CSRNP2 36
  • 75.82 (n)
  • 82.11 (a)
  • 93 (a)
(Anolis carolinensis)
Reptilia CSRNP2 37
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia csrnp2 36
  • 66.67 (n)
  • 70.66 (a)
(Danio rerio)
Actinopterygii csrnp2 36
  • 62.86 (n)
  • 62.38 (a)
csrnp2 37
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Axud1 37
  • 18 (a)
(Caenorhabditis elegans)
Secernentea C41D11.3 37
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7164 37
  • 26 (a)
Species with no ortholog for CSRNP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRNP2 Gene

Gene Tree for CSRNP2 (if available)
Gene Tree for CSRNP2 (if available)

Paralogs for CSRNP2 Gene

Paralogs for CSRNP2 Gene

Selected SIMAP similar genes for CSRNP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CSRNP2: view

Variants for CSRNP2 Gene

Sequence variations from dbSNP and Humsavar for CSRNP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs901310 -- 51,081,923(-) AAACT(C/T)TGCAA intron-variant, upstream-variant-2KB
rs901313 -- 51,081,065(-) AGTGA(G/T)CTGCC intron-variant
rs970097 -- 51,085,630(-) TCTCA(A/C)TTCTA upstream-variant-2KB
rs970098 -- 51,085,621(-) TAAAG(C/G)TGAGA upstream-variant-2KB
rs970099 -- 51,085,485(-) ATCAT(A/G)CTCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CSRNP2 Gene

Variant ID Type Subtype PubMed ID
esv34039 CNV Loss 18971310
esv2671499 CNV Deletion 23128226

Relevant External Links for CSRNP2 Gene

HapMap Linkage Disequilibrium report

Disorders for CSRNP2 Gene

Relevant External Links for CSRNP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CSRNP2: view

No data available for UniProtKB/Swiss-Prot for CSRNP2 Gene

Publications for CSRNP2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). (PMID: 17726538) Gingras S. … Ihle J.N. (PLoS ONE 2007) 2 3
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 49
  4. Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling. (PMID: 25391492) Lamoliatte F. … Thibault P. (Nat Commun 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CSRNP2 Gene

Sources for CSRNP2 Gene

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