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Aliases for CSRNP2 Gene

Aliases for CSRNP2 Gene

  • Cysteine And Serine Rich Nuclear Protein 2 2 3
  • Cysteine-Serine-Rich Nuclear Protein 2 2 3 5
  • Family With Sequence Similarity 130, Member A1 2 3
  • TGF-Beta-Induced Apoptosis Protein 12 3 4
  • C12orf22 3 4
  • FAM130A1 3 4
  • CSRNP-2 3 4
  • TAIP-12 3 4
  • Protein Phosphatase 1, Regulatory Subunit 72 3
  • Chromosome 12 Open Reading Frame 22 2
  • Protein Phosphatase 1 2
  • Regulatory Subunit 72 2
  • Protein FAM130A1 4
  • C12orf2 3
  • PPP1R72 3
  • TAIP12 4

External Ids for CSRNP2 Gene

Previous HGNC Symbols for CSRNP2 Gene

  • C12orf22
  • FAM130A1

Previous GeneCards Identifiers for CSRNP2 Gene

  • GC12M049743
  • GC12M051454
  • GC12M048487

Summaries for CSRNP2 Gene

Entrez Gene Summary for CSRNP2 Gene

  • The protein encoded by this gene belongs to the CSRNP family of nuclear proteins that share conserved regions, including cysteine- and serine- rich regions, a basic domain, a transcriptional activation domain, and bind the sequence 'AGAGTG', thus have the hallmark of transcription factors. Studies in mice suggest that these genes may have redundant functions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CSRNP2 Gene

CSRNP2 (Cysteine And Serine Rich Nuclear Protein 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. An important paralog of this gene is CSRNP3.

UniProtKB/Swiss-Prot for CSRNP2 Gene

  • Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity (By similarity). May play a role in apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRNP2 Gene

Genomics for CSRNP2 Gene

Regulatory Elements for CSRNP2 Gene

Promoters for CSRNP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CSRNP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CSRNP2 Gene

Chromosome:
12
Start:
51,061,205 bp from pter
End:
51,083,671 bp from pter
Size:
22,467 bases
Orientation:
Minus strand

Genomic View for CSRNP2 Gene

Genes around CSRNP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSRNP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSRNP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRNP2 Gene

Proteins for CSRNP2 Gene

  • Protein details for CSRNP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H175-CSRN2_HUMAN
    Recommended name:
    Cysteine/serine-rich nuclear protein 2
    Protein Accession:
    Q9H175

    Protein attributes for CSRNP2 Gene

    Size:
    543 amino acids
    Molecular mass:
    59591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CSRNP2 Gene

Proteomics data for CSRNP2 Gene at MOPED

Post-translational modifications for CSRNP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSRNP2 Gene

Antibody Products

No data available for DME Specific Peptides for CSRNP2 Gene

Domains & Families for CSRNP2 Gene

Gene Families for CSRNP2 Gene

Protein Domains for CSRNP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CSRNP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H175

UniProtKB/Swiss-Prot:

CSRN2_HUMAN :
  • Belongs to the AXUD1 family.
Family:
  • Belongs to the AXUD1 family.
genes like me logo Genes that share domains with CSRNP2: view

Function for CSRNP2 Gene

Molecular function for CSRNP2 Gene

UniProtKB/Swiss-Prot Function:
Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity (By similarity). May play a role in apoptosis.

Gene Ontology (GO) - Molecular Function for CSRNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,ISS 17726538
GO:0005515 protein binding IPI 15231748
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CSRNP2: view

Phenotypes for CSRNP2 Gene

genes like me logo Genes that share phenotypes with CSRNP2: view

Animal Models for CSRNP2 Gene

MGI Knock Outs for CSRNP2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSRNP2 Gene

Localization for CSRNP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRNP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSRNP2 Gene COMPARTMENTS Subcellular localization image for CSRNP2 gene
Compartment Confidence
nucleus 5
chloroplast 2
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for CSRNP2 Gene

Pathways & Interactions for CSRNP2 Gene

SuperPathways for CSRNP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CSRNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with CSRNP2: view

No data available for Pathways by source and SIGNOR curated interactions for CSRNP2 Gene

Drugs & Compounds for CSRNP2 Gene

No Compound Related Data Available

Transcripts for CSRNP2 Gene

Unigene Clusters for CSRNP2 Gene

Cysteine-serine-rich nuclear protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSRNP2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - -
SP5: - - - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for CSRNP2 Gene

GeneLoc Exon Structure for
CSRNP2
ECgene alternative splicing isoforms for
CSRNP2

Expression for CSRNP2 Gene

mRNA expression in normal human tissues for CSRNP2 Gene

Protein differential expression in normal tissues from HIPED for CSRNP2 Gene

This gene is overexpressed in Heart (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CSRNP2 Gene



SOURCE GeneReport for Unigene cluster for CSRNP2 Gene Hs.524425

genes like me logo Genes that share expression patterns with CSRNP2: view

Protein tissue co-expression partners for CSRNP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSRNP2 Gene

Orthologs for CSRNP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRNP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSRNP2 35
  • 90.48 (n)
  • 93.37 (a)
CSRNP2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSRNP2 35
  • 90.06 (n)
  • 93.92 (a)
CSRNP2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csrnp2 35
  • 86.45 (n)
  • 92.32 (a)
Csrnp2 16
Csrnp2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSRNP2 35
  • 99.69 (n)
  • 99.63 (a)
CSRNP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csrnp2 35
  • 86.54 (n)
  • 92.71 (a)
chicken
(Gallus gallus)
Aves CSRNP2 35
  • 75.82 (n)
  • 82.11 (a)
CSRNP2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSRNP2 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csrnp2 35
  • 66.67 (n)
  • 70.66 (a)
zebrafish
(Danio rerio)
Actinopterygii csrnp2 35
  • 62.86 (n)
  • 62.38 (a)
csrnp2 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Axud1 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C41D11.3 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7164 36
  • 26 (a)
OneToMany
Species with no ortholog for CSRNP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRNP2 Gene

ENSEMBL:
Gene Tree for CSRNP2 (if available)
TreeFam:
Gene Tree for CSRNP2 (if available)

Paralogs for CSRNP2 Gene

Paralogs for CSRNP2 Gene

(2) SIMAP similar genes for CSRNP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CSRNP2: view

Variants for CSRNP2 Gene

Sequence variations from dbSNP and Humsavar for CSRNP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_053016 -
rs901310 -- 51,081,923(-) AAACT(C/T)TGCAA intron-variant
rs901313 -- 51,081,065(-) AGTGA(G/T)CTGCC intron-variant
rs970097 -- 51,085,630(-) TCTCA(A/C/G)TTCTA upstream-variant-2KB
rs970098 -- 51,085,621(-) TAAAG(C/G)TGAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CSRNP2 Gene

Variant ID Type Subtype PubMed ID
esv34039 CNV Loss 18971310
esv2671499 CNV Deletion 23128226

Variation tolerance for CSRNP2 Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 57.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSRNP2 Gene

HapMap Linkage Disequilibrium report
CSRNP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSRNP2 Gene

Disorders for CSRNP2 Gene

Relevant External Links for CSRNP2

Genetic Association Database (GAD)
CSRNP2
Human Genome Epidemiology (HuGE) Navigator
CSRNP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSRNP2

No disorders were found for CSRNP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSRNP2 Gene

Publications for CSRNP2 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48 67
  2. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). (PMID: 17726538) Gingras S. … Ihle J.N. (PLoS ONE 2007) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A. … Bollen M. (Chem. Biol. 2009) 3

Products for CSRNP2 Gene

Sources for CSRNP2 Gene

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