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Aliases for CSRNP1 Gene

Aliases for CSRNP1 Gene

  • Cysteine-Serine-Rich Nuclear Protein 1 2 3
  • AXUD1 3 4 6
  • TGF-Beta-Induced Apoptosis Protein 3 3 4
  • Axin-1 Up-Regulated Gene 1 Protein 3 4
  • AXIN1 Up-Regulated 1 2 3
  • CSRNP-1 3 4
  • TAIP-3 3 4
  • Cysteine/Serine-Rich Nuclear Protein 1 3
  • TGF-Beta Induced Apoptosis Protein 3 3
  • Protein URAX1 4
  • FAM130B 3
  • URAX1 3
  • TAIP3 4

External Ids for CSRNP1 Gene

Previous HGNC Symbols for CSRNP1 Gene

  • AXUD1

Summaries for CSRNP1 Gene

Entrez Gene Summary for CSRNP1 Gene

  • This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSRNP1 Gene

CSRNP1 (Cysteine-Serine-Rich Nuclear Protein 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CSRNP2.

UniProtKB/Swiss-Prot for CSRNP1 Gene

  • Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRNP1 Gene

Genomics for CSRNP1 Gene

Regulatory Elements for CSRNP1 Gene

Genomic Location for CSRNP1 Gene

Start:
39,141,851 bp from pter
End:
39,154,602 bp from pter
Size:
12,752 bases
Orientation:
Minus strand

Genomic View for CSRNP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSRNP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRNP1 Gene

Proteins for CSRNP1 Gene

  • Protein details for CSRNP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S65-CSRN1_HUMAN
    Recommended name:
    Cysteine/serine-rich nuclear protein 1
    Protein Accession:
    Q96S65
    Secondary Accessions:
    • Q69YY5

    Protein attributes for CSRNP1 Gene

    Size:
    589 amino acids
    Molecular mass:
    63508 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CSRNP1 Gene

Proteomics data for CSRNP1 Gene at MOPED

Post-translational modifications for CSRNP1 Gene

  • Ubiquitination at Lys74
  • Modification sites at PhosphoSitePlus

Other Protein References for CSRNP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CSRNP1 Gene

Domains for CSRNP1 Gene

Protein Domains for CSRNP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CSRNP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S65

UniProtKB/Swiss-Prot:

CSRN1_HUMAN :
  • Q96S65
Family:
  • Belongs to the AXUD1 family.
genes like me logo Genes that share domains with CSRNP1: view

No data available for Gene Families for CSRNP1 Gene

Function for CSRNP1 Gene

Molecular function for CSRNP1 Gene

UniProtKB/Swiss-Prot Function: Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.

Gene Ontology (GO) - Molecular Function for CSRNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003674 molecular_function ND --
GO:0003700 sequence-specific DNA binding transcription factor activity ISS 17726538
GO:0005515 protein binding IPI 22321011
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CSRNP1: view
genes like me logo Genes that share phenotypes with CSRNP1: view

Animal Models for CSRNP1 Gene

MGI Knock Outs for CSRNP1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CSRNP1 Gene

Localization for CSRNP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRNP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSRNP1 Gene COMPARTMENTS Subcellular localization image for CSRNP1 gene
Compartment Confidence
nucleus 4
chloroplast 2
cytosol 2

Gene Ontology (GO) - Cellular Components for CSRNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 17726538
genes like me logo Genes that share ontologies with CSRNP1: view

Pathways for CSRNP1 Gene

SuperPathways for CSRNP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CSRNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006915 apoptotic process NAS 11526492
GO:0009791 post-embryonic development IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS 17726538
genes like me logo Genes that share ontologies with CSRNP1: view

No data available for Pathways by source for CSRNP1 Gene

Transcripts for CSRNP1 Gene

mRNA/cDNA for CSRNP1 Gene

Unigene Clusters for CSRNP1 Gene

Cysteine-serine-rich nuclear protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSRNP1 Gene

No ASD Table

Relevant External Links for CSRNP1 Gene

GeneLoc Exon Structure for
CSRNP1
ECgene alternative splicing isoforms for
CSRNP1

Expression for CSRNP1 Gene

mRNA expression in normal human tissues for CSRNP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSRNP1 Gene

This gene is overexpressed in Whole Blood (6.3).

SOURCE GeneReport for Unigene cluster for CSRNP1 Gene Hs.370950

mRNA Expression by UniProt/SwissProt for CSRNP1 Gene

Q96S65-CSRN1_HUMAN
Tissue specificity: Ubiquitous. Most abundantly expressed in lung, placenta, skeletal muscle, pancreas and leukocyte. Frequently down-regulated in lung, kidney, liver and colon cancers compared with their corresponding normal tissues.
genes like me logo Genes that share expressions with CSRNP1: view

No data available for Protein expression for CSRNP1 Gene

Orthologs for CSRNP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRNP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSRNP1 35
  • 99.26 (n)
  • 99.14 (a)
CSRNP1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSRNP1 35
  • 82.74 (n)
  • 82.91 (a)
CSRNP1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSRNP1 35
  • 83.93 (n)
  • 83.42 (a)
CSRNP1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csrnp1 35
  • 77.93 (n)
  • 74.61 (a)
Csrnp1 16
Csrnp1 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csrnp1 35
  • 75.71 (n)
  • 72.54 (a)
chicken
(Gallus gallus)
Aves CSRNP1 35
  • 59.61 (n)
  • 52.01 (a)
CSRNP1 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSRNP1 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csrnp1 35
  • 54.22 (n)
  • 48.43 (a)
zebrafish
(Danio rerio)
Actinopterygii csrnp1a 36
  • 37 (a)
OneToMany
csrnp1b 35
  • 56.85 (n)
  • 50.93 (a)
csrnp1b 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Axud1 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C41D11.3 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7164 36
  • 25 (a)
OneToMany
Species with no ortholog for CSRNP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRNP1 Gene

ENSEMBL:
Gene Tree for CSRNP1 (if available)
TreeFam:
Gene Tree for CSRNP1 (if available)

Paralogs for CSRNP1 Gene

Paralogs for CSRNP1 Gene

Selected SIMAP similar genes for CSRNP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CSRNP1: view

Variants for CSRNP1 Gene

Sequence variations from dbSNP and Humsavar for CSRNP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs704960 -- 39,142,862(-) GGACT(A/G/T)GGGGG utr-variant-3-prime
rs784501 -- 39,142,404(-) CTCTG(C/T)GGGCA utr-variant-3-prime
rs784516 -- 39,146,106(-) CAAGC(C/T)GGTCC intron-variant
rs784517 -- 39,145,237(-) AAGCG(A/C/G)GCTCG synonymous-codon, reference
rs784518 -- 39,144,547(-) AGTGG(C/G)GGGGT intron-variant

Relevant External Links for CSRNP1 Gene

HapMap Linkage Disequilibrium report
CSRNP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CSRNP1 Gene

Disorders for CSRNP1 Gene

Relevant External Links for CSRNP1

Genetic Association Database (GAD)
CSRNP1
genes like me logo Genes that share disorders with CSRNP1: view

No data available for UniProtKB/Swiss-Prot for CSRNP1 Gene

Publications for CSRNP1 Gene

  1. Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney. (PMID: 11526492) Ishiguro H. … Furukawa Y. (Oncogene 2001) 2 3 4 23
  2. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). (PMID: 17726538) Gingras S. … Ihle J.N. (PLoS ONE 2007) 2 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for CSRNP1 Gene

Sources for CSRNP1 Gene

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