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Aliases for CSRNP1 Gene

Aliases for CSRNP1 Gene

  • Cysteine And Serine Rich Nuclear Protein 1 2 3 5
  • TGF-Beta-Induced Apoptosis Protein 3 3 4
  • Axin-1 Up-Regulated Gene 1 Protein 3 4
  • AXIN1 Up-Regulated 1 2 3
  • CSRNP-1 3 4
  • TAIP-3 3 4
  • AXUD1 3 4
  • Cysteine-Serine-Rich Nuclear Protein 1 2
  • Cysteine/Serine-Rich Nuclear Protein 1 3
  • Protein URAX1 4
  • FAM130B 3
  • URAX1 3
  • TAIP3 4

External Ids for CSRNP1 Gene

Previous HGNC Symbols for CSRNP1 Gene

  • AXUD1

Summaries for CSRNP1 Gene

Entrez Gene Summary for CSRNP1 Gene

  • This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for CSRNP1 Gene

CSRNP1 (Cysteine And Serine Rich Nuclear Protein 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. An important paralog of this gene is CSRNP3.

UniProtKB/Swiss-Prot for CSRNP1 Gene

  • Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRNP1 Gene

Genomics for CSRNP1 Gene

Regulatory Elements for CSRNP1 Gene

Enhancers for CSRNP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F039145 1.6 FANTOM5 ENCODE 12 +3.5 3501 10.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GORASP1 TTC21A CSRNP1 MIR6822 XIRP1 SNORA62 CX3CR1 EXOG WDR48 LOC101928263
GH03F039266 1.2 FANTOM5 Ensembl ENCODE 15.3 -113.7 -113694 3.4 ZNF639 KLF1 ZBTB11 EBF1 ZNF589 IKZF1 HMBOX1 IRF1 GORASP1 CSRNP1 XIRP1 CCR8 HNRNPA1P21 MIR6822 TTC21A RPSA WDR48 SLC25A38
GH03F039175 1.3 Ensembl ENCODE 12.5 -25.5 -25450 8.7 HDGF PKNOX1 ARID4B SIN3A YBX1 YY1 FOS KLF13 ZNF263 SP3 GORASP1 CSRNP1 CX3CR1 TTC21A MIR6822 RPSA PIR56273 XIRP1
GH03F039124 1.2 Ensembl ENCODE 12.9 +27.9 27873 3.8 HDGF PKNOX1 YY1 ZNF766 FOS ZNF263 MCM3 NCOA1 REST MBD2 TTC21A CSRNP1 WDR48 XIRP1 CX3CR1 GORASP1 LOC101928263
GH03F039248 1.2 Ensembl ENCODE 11.6 -99.4 -99404 10.4 HDGF PKNOX1 WRNIP1 YY1 ZNF121 CBX5 ZNF143 FOS JUNB REST CX3CR1 XIRP1 CSRNP1 RPSA GORASP1 EXOG LOC102724104
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CSRNP1 on UCSC Golden Path with GeneCards custom track

Promoters for CSRNP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001361536 1397 2801 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF143 FOS KLF13

Genomic Location for CSRNP1 Gene

Chromosome:
3
Start:
39,141,851 bp from pter
End:
39,154,597 bp from pter
Size:
12,747 bases
Orientation:
Minus strand

Genomic View for CSRNP1 Gene

Genes around CSRNP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSRNP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSRNP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRNP1 Gene

Proteins for CSRNP1 Gene

  • Protein details for CSRNP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S65-CSRN1_HUMAN
    Recommended name:
    Cysteine/serine-rich nuclear protein 1
    Protein Accession:
    Q96S65
    Secondary Accessions:
    • Q69YY5

    Protein attributes for CSRNP1 Gene

    Size:
    589 amino acids
    Molecular mass:
    63508 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CSRNP1 Gene

Post-translational modifications for CSRNP1 Gene

  • Ubiquitination at Lys 74
  • Modification sites at PhosphoSitePlus

Other Protein References for CSRNP1 Gene

Antibody Products

  • Abcam antibodies for CSRNP1

No data available for DME Specific Peptides for CSRNP1 Gene

Domains & Families for CSRNP1 Gene

Protein Domains for CSRNP1 Gene

Suggested Antigen Peptide Sequences for CSRNP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S65

UniProtKB/Swiss-Prot:

CSRN1_HUMAN :
  • Belongs to the AXUD1 family.
Family:
  • Belongs to the AXUD1 family.
genes like me logo Genes that share domains with CSRNP1: view

No data available for Gene Families for CSRNP1 Gene

Function for CSRNP1 Gene

Molecular function for CSRNP1 Gene

UniProtKB/Swiss-Prot Function:
Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.

Gene Ontology (GO) - Molecular Function for CSRNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding ISS 17726538
GO:0005515 protein binding IPI 22321011
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CSRNP1: view
genes like me logo Genes that share phenotypes with CSRNP1: view

Animal Models for CSRNP1 Gene

MGI Knock Outs for CSRNP1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CSRNP1 Gene

Localization for CSRNP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRNP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSRNP1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CSRNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 17726538
genes like me logo Genes that share ontologies with CSRNP1: view

Pathways & Interactions for CSRNP1 Gene

SuperPathways for CSRNP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CSRNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006915 apoptotic process NAS 11526492
GO:0009791 post-embryonic development IEA --
genes like me logo Genes that share ontologies with CSRNP1: view

No data available for Pathways by source and SIGNOR curated interactions for CSRNP1 Gene

Transcripts for CSRNP1 Gene

Unigene Clusters for CSRNP1 Gene

Cysteine-serine-rich nuclear protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSRNP1 Gene

No ASD Table

Relevant External Links for CSRNP1 Gene

GeneLoc Exon Structure for
CSRNP1
ECgene alternative splicing isoforms for
CSRNP1

Expression for CSRNP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CSRNP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSRNP1 Gene

This gene is overexpressed in Whole Blood (x6.3).

NURSA nuclear receptor signaling pathways regulating expression of CSRNP1 Gene:

CSRNP1

SOURCE GeneReport for Unigene cluster for CSRNP1 Gene:

Hs.370950

mRNA Expression by UniProt/SwissProt for CSRNP1 Gene:

Q96S65-CSRN1_HUMAN
Tissue specificity: Ubiquitous. Most abundantly expressed in lung, placenta, skeletal muscle, pancreas and leukocyte. Frequently down-regulated in lung, kidney, liver and colon cancers compared with their corresponding normal tissues.
genes like me logo Genes that share expression patterns with CSRNP1: view

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CSRNP1 Gene

Orthologs for CSRNP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRNP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSRNP1 34 35
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia CSRNP1 34 35
  • 83.93 (n)
cow
(Bos Taurus)
Mammalia CSRNP1 34 35
  • 82.74 (n)
mouse
(Mus musculus)
Mammalia Csrnp1 34 16 35
  • 77.93 (n)
rat
(Rattus norvegicus)
Mammalia Csrnp1 34
  • 75.71 (n)
chicken
(Gallus gallus)
Aves CSRNP1 34 35
  • 59.61 (n)
lizard
(Anolis carolinensis)
Reptilia CSRNP1 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csrnp1 34
  • 54.22 (n)
zebrafish
(Danio rerio)
Actinopterygii csrnp1b 34 35
  • 56.85 (n)
csrnp1a 35
  • 37 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Axud1 35
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C41D11.3 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7164 35
  • 25 (a)
OneToMany
Species where no ortholog for CSRNP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRNP1 Gene

ENSEMBL:
Gene Tree for CSRNP1 (if available)
TreeFam:
Gene Tree for CSRNP1 (if available)

Paralogs for CSRNP1 Gene

Paralogs for CSRNP1 Gene

(2) SIMAP similar genes for CSRNP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CSRNP1: view

Variants for CSRNP1 Gene

Sequence variations from dbSNP and Humsavar for CSRNP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs147162469 untested 39,143,393(+) AGGAA(A/G)GCTGC reference, missense
rs10593849 -- 39,147,066(+) ACACA(-/CACA)TGCAT intron-variant
rs10679310 -- 39,147,236(+) TGTGT(-/CTGT/GTAT/GTGT/TA)ATGTG intron-variant, utr-variant-5-prime
rs1105163 -- 39,146,860(+) TGGAG(C/T)TCTGT intron-variant, upstream-variant-2KB
rs111245611 -- 39,148,192(+) GGGAA(A/G)ACTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CSRNP1 Gene

Variant ID Type Subtype PubMed ID
nsv590106 CNV loss 21841781
nsv590102 CNV loss 21841781
dgv8287n54 CNV loss 21841781

Variation tolerance for CSRNP1 Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 29.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSRNP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSRNP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSRNP1 Gene

Disorders for CSRNP1 Gene

Relevant External Links for CSRNP1

Genetic Association Database (GAD)
CSRNP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSRNP1

No disorders were found for CSRNP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSRNP1 Gene

Publications for CSRNP1 Gene

  1. Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney. (PMID: 11526492) Ishiguro H. … Furukawa Y. (Oncogene 2001) 2 3 4 22 64
  2. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). (PMID: 17726538) Gingras S. … Ihle J.N. (PLoS ONE 2007) 2 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence. (PMID: 24564958) St Pourcain B. … Smith G.D. (Mol Autism 2014) 3 64

Products for CSRNP1 Gene

Sources for CSRNP1 Gene

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