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Aliases for CSRNP1 Gene

Aliases for CSRNP1 Gene

  • Cysteine And Serine Rich Nuclear Protein 1 2 3 5
  • TGF-Beta-Induced Apoptosis Protein 3 3 4
  • Axin-1 Up-Regulated Gene 1 Protein 3 4
  • AXIN1 Up-Regulated 1 2 3
  • CSRNP-1 3 4
  • TAIP-3 3 4
  • AXUD1 3 4
  • Cysteine-Serine-Rich Nuclear Protein 1 2
  • Cysteine/Serine-Rich Nuclear Protein 1 3
  • Protein URAX1 4
  • FAM130B 3
  • URAX1 3
  • TAIP3 4

External Ids for CSRNP1 Gene

Previous HGNC Symbols for CSRNP1 Gene

  • AXUD1

Summaries for CSRNP1 Gene

Entrez Gene Summary for CSRNP1 Gene

  • This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for CSRNP1 Gene

CSRNP1 (Cysteine And Serine Rich Nuclear Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is CSRNP3.

UniProtKB/Swiss-Prot for CSRNP1 Gene

  • Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.

Additional gene information for CSRNP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRNP1 Gene

Genomics for CSRNP1 Gene

GeneHancer (GH) Regulatory Elements for CSRNP1 Gene

Promoters and enhancers for CSRNP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I039145 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 562 +3.5 3500 10.7 CLOCK FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 ZNF263 SP3 MEF2D CSRNP1 LOC101928263 ENSG00000283849 GORASP1 TTC21A SNORA62 CX3CR1 XIRP1 MOBP ACVR2B-AS1
GH03I039106 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.7 +47.0 47002 2.7 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 SP3 SP5 TTC21A GORASP1 CX3CR1 CSRNP1 MOBP SCN11A PIR55888 GC03M039097
GH03I039266 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -113.7 -113694 3.4 KLF1 TEAD4 EBF1 ZNF507 FOSL1 ZNF766 POLR2A PRDM10 IKZF2 RUNX3 GORASP1 CSRNP1 XIRP1 CCR8 HNRNPA1P21 TTC21A RPSA WDR48 SLC25A38 CX3CR1
GH03I039175 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.5 -25.4 -25449 8.7 HDGF CLOCK FOXA2 ARID4B SIN3A YBX1 YY1 POLR2B FOS ZNF263 PIR56273 GORASP1 CSRNP1 CX3CR1 TTC21A RPSA LOC105377035 XIRP1
GH03I039124 Enhancer 1.3 Ensembl ENCODE dbSUPER 13 +28.1 28132 3.2 HDAC1 HDGF ARNT ZSCAN4 NEUROD1 RAD21 ARID2 ZNF143 FOS RUNX3 TTC21A CSRNP1 GORASP1 OXSR1 SNORA62 XIRP1 CX3CR1 MIR6822
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CSRNP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CSRNP1 gene promoter:

Genomic Locations for CSRNP1 Gene

Genomic Locations for CSRNP1 Gene
chr3:39,141,851-39,154,597
(GRCh38/hg38)
Size:
12,747 bases
Orientation:
Minus strand
chr3:39,183,342-39,196,053
(GRCh37/hg19)

Genomic View for CSRNP1 Gene

Genes around CSRNP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSRNP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSRNP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRNP1 Gene

Proteins for CSRNP1 Gene

  • Protein details for CSRNP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S65-CSRN1_HUMAN
    Recommended name:
    Cysteine/serine-rich nuclear protein 1
    Protein Accession:
    Q96S65
    Secondary Accessions:
    • Q69YY5

    Protein attributes for CSRNP1 Gene

    Size:
    589 amino acids
    Molecular mass:
    63508 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CSRNP1 Gene

Post-translational modifications for CSRNP1 Gene

Other Protein References for CSRNP1 Gene

No data available for DME Specific Peptides for CSRNP1 Gene

Domains & Families for CSRNP1 Gene

Gene Families for CSRNP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for CSRNP1 Gene

Suggested Antigen Peptide Sequences for CSRNP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S65

UniProtKB/Swiss-Prot:

CSRN1_HUMAN :
  • Belongs to the AXUD1 family.
Family:
  • Belongs to the AXUD1 family.
genes like me logo Genes that share domains with CSRNP1: view

Function for CSRNP1 Gene

Molecular function for CSRNP1 Gene

UniProtKB/Swiss-Prot Function:
Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.

Phenotypes From GWAS Catalog for CSRNP1 Gene

Gene Ontology (GO) - Molecular Function for CSRNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA --
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity ISS 17726538
GO:0005515 protein binding IPI 22321011
genes like me logo Genes that share ontologies with CSRNP1: view
genes like me logo Genes that share phenotypes with CSRNP1: view

Animal Models for CSRNP1 Gene

MGI Knock Outs for CSRNP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CSRNP1 Gene

Localization for CSRNP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRNP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSRNP1 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CSRNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 17726538
genes like me logo Genes that share ontologies with CSRNP1: view

Pathways & Interactions for CSRNP1 Gene

SuperPathways for CSRNP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CSRNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0006915 apoptotic process NAS 11526492
GO:0009791 post-embryonic development IEA --
genes like me logo Genes that share ontologies with CSRNP1: view

No data available for Pathways by source and SIGNOR curated interactions for CSRNP1 Gene

Drugs & Compounds for CSRNP1 Gene

No Compound Related Data Available

Transcripts for CSRNP1 Gene

Unigene Clusters for CSRNP1 Gene

Cysteine-serine-rich nuclear protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSRNP1 Gene

No ASD Table

Relevant External Links for CSRNP1 Gene

GeneLoc Exon Structure for
CSRNP1
ECgene alternative splicing isoforms for
CSRNP1

Expression for CSRNP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSRNP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSRNP1 Gene

This gene is overexpressed in Whole Blood (x6.3).

NURSA nuclear receptor signaling pathways regulating expression of CSRNP1 Gene:

CSRNP1

SOURCE GeneReport for Unigene cluster for CSRNP1 Gene:

Hs.370950

mRNA Expression by UniProt/SwissProt for CSRNP1 Gene:

Q96S65-CSRN1_HUMAN
Tissue specificity: Ubiquitous. Most abundantly expressed in lung, placenta, skeletal muscle, pancreas and leukocyte. Frequently down-regulated in lung, kidney, liver and colon cancers compared with their corresponding normal tissues.

Evidence on tissue expression from TISSUES for CSRNP1 Gene

  • Kidney(4.2)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with CSRNP1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSRNP1 Gene

Orthologs for CSRNP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRNP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSRNP1 33 34
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia CSRNP1 33 34
  • 83.93 (n)
cow
(Bos Taurus)
Mammalia CSRNP1 33 34
  • 82.74 (n)
mouse
(Mus musculus)
Mammalia Csrnp1 33 16 34
  • 77.93 (n)
rat
(Rattus norvegicus)
Mammalia Csrnp1 33
  • 75.71 (n)
chicken
(Gallus gallus)
Aves CSRNP1 33 34
  • 59.61 (n)
lizard
(Anolis carolinensis)
Reptilia CSRNP1 34
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csrnp1 33
  • 54.22 (n)
zebrafish
(Danio rerio)
Actinopterygii csrnp1b 33 34
  • 56.85 (n)
csrnp1a 34
  • 37 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Axud1 34
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C41D11.3 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7164 34
  • 25 (a)
OneToMany
Species where no ortholog for CSRNP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRNP1 Gene

ENSEMBL:
Gene Tree for CSRNP1 (if available)
TreeFam:
Gene Tree for CSRNP1 (if available)

Paralogs for CSRNP1 Gene

Paralogs for CSRNP1 Gene

(2) SIMAP similar genes for CSRNP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CSRNP1: view

Variants for CSRNP1 Gene

Sequence variations from dbSNP and Humsavar for CSRNP1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs147162469 not-provided, not provided 39,143,393(-) G/A coding_sequence_variant, missense_variant
rs1000184066 -- 39,153,445(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000198980 -- 39,150,353(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000632803 -- 39,150,045(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000639366 -- 39,153,187(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CSRNP1 Gene

Variant ID Type Subtype PubMed ID
dgv8287n54 CNV loss 21841781
nsv590102 CNV loss 21841781
nsv590106 CNV loss 21841781

Variation tolerance for CSRNP1 Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 29.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSRNP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSRNP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSRNP1 Gene

Disorders for CSRNP1 Gene

Additional Disease Information for CSRNP1

No disorders were found for CSRNP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSRNP1 Gene

Publications for CSRNP1 Gene

  1. Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney. (PMID: 11526492) Ishiguro H … Furukawa Y (Oncogene 2001) 2 3 4 22 58
  2. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). (PMID: 17726538) Gingras S … Ihle JN (PloS one 2007) 2 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for CSRNP1 Gene

Sources for CSRNP1 Gene

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