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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSPP1 Gene

protein-coding   GIFtS: 47
GCID: GC08P067976

centrosome and spindle pole associated protein 1

 Explore 2 diseases affiliated with
CSPP1 via our new
 Human Malady Compendium 
Biological research products
for CSPP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Centrosome And Spindle Pole Associated Protein 11 2
CSPP1 2 3 5
FLJ224901
Centrosome And Spindle Pole-Associated Protein 12

External Ids:    HGNC: 261931   Entrez Gene: 798482   Ensembl: ENSG000001042187   OMIM: 6116545   UniProtKB: Q1MSJ53   

Export aliases for CSPP1 gene to outside databases

Previous GC identifers: GC08P068141 GC08P063469


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSPP1:
CSPP1 interacts with centrosomes and microtubules and plays a role in cell-cycle progression and spindle organization
(Patzke et al., 2005 (PubMed 15580290); Patzke et al., 2006 (PubMed 16826565)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: CSPP1_HUMAN, Q1MSJ5
Function: May play a role in cell-cycle-dependent microtubule organization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSPP1 gene promoter:
         HFH-3   Pax-2   Pax-2a   FOXI1   MEF-2A   Pax-2b   NRF-2   POU2F1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSPP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CSPP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSPP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.2   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q13.2

CSPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSPP1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P067976:  view genomic region     (about GC identifiers)

Start:
67,974,661 bp from pter      End:
68,108,849 bp from pter
Size:
134,189 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CSPP1_HUMAN, Q1MSJ5 (See protein sequence)
Recommended Name: Centrosome and spindle pole-associated protein 1  
Size: 1256 amino acids; 145522 Da
Subunit: Interacts with PLEKHG6 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton,
spindle pole (By similarity). Note=Associated with mitotic spindles
Developmental stage: Isoform 1 expression increases throughout the cell cycle and peaks in G2/M phase. Isoform 2
expression is highest in G1 phase and decreases thereafter
Sequence caution: Sequence=AAH22867.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6ND63 Q70F00 Q8TBC1
Alternative splicing: 3 isoforms:  Q1MSJ5-3   Q1MSJ5-1   Q1MSJ5-2   

Explore the universe of human proteins at neXtProt for CSPP1: NX_Q1MSJ5

Post-translational modifications:

  • Phosphorylated. Phosphorylation increases in colcemide-treated cells1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q1MSJ5

  • CSPP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079066.5  
    ENSEMBL proteins: 
     ENSP00000429546   ENSP00000262210   ENSP00000428793   ENSP00000428694   ENSP00000430092  
     ENSP00000415782  

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    Uscn Proteins for CSPP1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA19129481
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--
    GO:0005819spindle IDA19129481
    GO:0005874microtubule IEA--


    CSPP1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CSPP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026708 CSPP1

    Graphical View of Domain Structure for InterPro Entry Q1MSJ5

    ProtoNet protein and cluster: Q1MSJ5


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CSPP1_HUMAN, Q1MSJ5
    Function: May play a role in cell-cycle-dependent microtubule organization

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    CSPP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CSPP1:
     Decreased p24 protein expressi 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSPP1

    1 Interacting protein for CSPP1 (Q1MSJ53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051781positive regulation of cell division IMP19129481
    GO:0071777positive regulation of cell cycle cytokinesis IMP19129481


    CSPP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CSPP1
    Search CenterWatch for drugs/clinical trials and news about CSPP1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CSPP1 gene (2 alternative transcripts): 
    NM_001077204.1  NM_024790.6  

    Unigene Cluster for CSPP1:

    Centrosome and spindle pole associated protein 1
    Hs.370147  [show with all ESTs]
    Unigene Representative Sequence: NM_024790
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521919 ENST00000262210(uc003xxj.3 uc003xxi.3 uc003xxk.3 uc010lyw.3)
    ENST00000519701 ENST00000519163(uc003xxg.1 uc003xxh.1) ENST00000519668
    ENST00000521168 ENST00000521324 ENST00000412460

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    Inhib. RNA
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    Additional cDNA sequence: 

    AJ583433.1 AK096205.1 AK127108.1 AK308372.1 AM156947.1 BC022867.1 BC029445.1 BX649147.1 

    18 DOTS entries:

    DT.443891  DT.97840977  DT.100023962  DT.91721224  DT.40213904  DT.99964206  DT.100673897  DT.100670730 
    DT.99944378  DT.100044163  DT.103289  DT.75173739  DT.87004357  DT.120640439  DT.120640566  DT.120640598 
    DT.120640610  DT.70104798 

    24/103 AceView cDNA sequences (see all 103):

    AK127108 BE467727 AA721643 BM555375 BF115634 BU685185 BC029445 AI760177 
    BX649147 BM767347 AI125328 AW451189 BQ012105 BF223888 AI400587 AA721639 
    AI621096 H54754 AA883157 AK096205 CB243947 BM914827 AL042666 BM771016 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CSPP1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                          -                                                                                                                                 
    SP2:                          -                 -                                                                                                               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                    -               
    SP5:                                    


    ECgene alternative splicing isoforms for CSPP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSPP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGTAACTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CSPP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSPP1

    SOURCE GeneReport for Unigene cluster: Hs.370147

    UniProtKB/Swiss-Prot: CSPP1_HUMAN, Q1MSJ5
    Tissue specificity: Detected in testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CSPP1 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cspp11 , 5 centrosome and spindle pole associated protein 11, 5 83.52(n)1
    79.45(a)1
      1 (2.30 cM)5
    2116601  NM_026493.31  NP_080769.31 
     100382185 
    chicken
    (Gallus gallus)
    Aves CSPP11 centrosome and spindle pole associated protein 1 67.7(n)
    59.31(a)
      420169  XM_418282.3  XP_418282.3 
    lizard
    (Anolis carolinensis)
    Reptilia CSPP16
    --
    54(a)
    1 ↔ 1
    4(31117171-31171649)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.43862 Xenopus laevis transcribed sequence with weak similarity to protein pirT46481 (H.sapiens) T46481 hypothetical protein DKFZp434A025.1 - human (fragment) less 75.2(n)    CA787974.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-97a13.91 si:dkey-97a13.9 53.94(n)
    44.44(a)
      570598  XM_694098.4  XP_699190.3 


    ENSEMBL Gene Tree for CSPP1 (if available)
    TreeFam Gene Tree for CSPP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1757 NCBI SNPs in CSPP1 are shown (see all 1757    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617353151,2
    --67976577(+) GTTGGC/TGAAGG 1 -- us2k12Minor allele frequency- T:0.02NS NA 196
    rs1814708461,2
    C,F,--67976663(+) GCTGTA/GACCTC 2 V syn11Minor allele frequency- G:0.01EU 1267
    rs2002507311,2
    --67976683(+) CGACGA/GTCCTC 2 D G mis10--------
    rs1172107471,2
    C,F,--67976750(+) AGCCGC/GGGATG 1 -- int11Minor allele frequency- G:0.04NA 120
    rs1143503751,2
    C,F,--67976754(+) GCGGAT/AGGGGA 1 -- int11Minor allele frequency- A:0.25WA 118
    rs132738661,2
    --67976792(+) TGGTGT/CAGGTT 1 -- int12Minor allele frequency- C:0.25NA 4
    rs1862062621,2
    --67976918(+) CTCTGC/GAATCT 1 -- int10--------
    rs1400606051,2
    C,--67976930(+) GGGGT-/GGGGGT 1 -- int10--------
    rs761815001,2
    C,--67977009(+) GTGGAG/TAGTTG 1 -- int13Minor allele frequency- T:0.22NA EA 242
    rs1147906911,2
    F,--67977158(+) CGGTCG/TCTGCT 1 -- int11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for CSPP1 (67974661 - 68108849 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CSPP1
         1 CNV: 1790

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CSPP1 for disorders           About GeneDecksing

    OMIM gene information: 611654    OMIM disorders: --

    2 diseases for CSPP1:    About MalaCards
    plasmodium vivax malaria    malaria

    Human Genome Epidemiology (HuGE) Navigator: CSPP1 (1 document)

    Export disorders for CSPP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSPP1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CSPP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel centrosome/microtubule-associated coiled- coil protein involved in cell-cycle progression and spindle organization. (PubMed id 15580290)1, 2, 3, 9 Patzke S.... Aasheim H.-C. (2005)
    2. CSPP and CSPP-L associate with centrosomes and microtubules and differently affect microtubule organization. (PubMed id 16826565)1, 2, 9 Patzke S.... Aasheim H.-C. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle. (PubMed id 19129481)1, 9 Asiedu M....Wei Q. (2009)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. CSPP is a ciliary protein interacting with Nephrocyst in 8 and required for cilia formation. (PubMed id 20519441)1 Patzke S....Stokke T. (2010)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79848 HGNC: 26193 AceView: FLJ22490 Ensembl:ENSG00000104218 euGenes: HUgn79848
    ECgene: CSPP1 H-InvDB: CSPP1

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for CSPP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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