CSPG5 Gene

Aliases
for CSPG5 gene

Previous GC identifers: GC03M047401 GC03M046808 GC03M047564 GC03M047578

Summaries
for CSPG5 gene

Genomic Views
for CSPG5 gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_022517.18  

SwitchGear Promoter luciferase reporter plasmid: CSPG5 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSPG5

CSPG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M047603:  view genomic region     (about GC identifiers)

Proteins
for CSPG5 gene

Explore the universe of human proteins at neXtProt for CSPG5: NX_O95196

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CSPG5 (Neuroglycan C/CSPG5)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CSPG5
	GenScript Custom Purified and Recombinant Proteins Services for CSPG5
	Novus Biologicals CSPG5 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CSPG5

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CSPG5 (Neuroglycan C/CSPG5)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CSPG5
	GenScript Custom Superior Antibodies Services for CSPG5
	Novus Biologicals CSPG5 Antibodies
	Search for Antibodies for CSPG5 at Abcam
	Uscn Antibodies for CSPG5
	Search ThermoFisher Antibodies for CSPG5

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CSPG5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CSPG5

Protein Domains /
Families
for CSPG5 gene

ProtoNet protein and cluster: O95196

Function
for CSPG5 gene

miRNA Products:		OriGene 3'-UTR Clone: CSPG5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSPG5
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CSPG5:
		hsa-miR-223 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-548k hsa-miR-3613-3p hsa-miR-486-5p
		SwitchGear 3'UTR luciferase reporter plasmid: CSPG5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSPG5 (see all 7) OriGene shRNA RFP: CSPG5 OriGene siRNA: CSPG5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSPG5

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CSPG5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSPG5 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSPG5 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CSPG5 (NM_006574)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSPG5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSPG5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CSPG5
		Search LifeMap BioReagents cell lines for CSPG5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSPG5

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Cspg5)

Pathways & Interactions
for CSPG5 gene

	Super-pathway	contained gene-specific pathways
1	MPS IIIC - Sanfilippo syndrome C	8/15 pathways (see all 15) MPS IIIC - Sanfilippo syndrome C 1.00 MPS IIID - Sanfilippo syndrome D 1.00 MPS I - Hurler syndrome 1.00 MPS IX - Natowicz syndrome 1.00 Mucopolysaccharidoses 1.00 MPS II - Hunter syndrome 1.00 MPS IV - Morquio syndrome A 1.00 Glycosaminoglycan metabolism 1.00
2	DSPGs are secreted	DSPG and CSPG translocate to the lysosome for degradation 1.00 CSPG is secreted 1.00 DSPGs are secreted 1.00 Dermatan sulfate biosynthesis 0.70 CS is cleaved from its proteoglycan 1.00 CS/DS degradation 0.54 DS is cleaved from its proteoglycan 1.00
3	A tetrasaccharide linker sequence is required for GAG synthesis	A tetrasaccharide linker sequence is required for GAG synthesis 1.00 Chondroitin sulfate/dermatan sulfate metabolism 0.54
4	Disease	Disease 1.00
5	Metabolism	Metabolism 1.00

5/27        Reactome Pathways for CSPG5

	Chondroitin sulfate/dermatan sulfate metabolism
	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	DSPG and CSPG translocate to the lysosome for degradation
	Disease

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

Drugs & Compounds
for CSPG5 gene

Transcripts
for CSPG5 gene

Expression
for CSPG5 gene

CSPG5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTTATGTA

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainBlood Brain BarrierAdult Endothelial Cells			Blood Brain Barrier, Endothelium
	BrainBlood Brain BarrierPostnatal Endothelial Cells			Blood Brain Barrier, Endothelium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSPG5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSPG5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSPG5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSPG5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSPG5

Orthologs
for CSPG5 gene

Paralogs
for CSPG5 gene

Genomic Variants
for CSPG5 gene

10/285 NCBI SNPs in CSPG5 are shown (see all 285)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1840434601,2	C,	other	84875174(+)	AGGACA/GAGGGC	10	L	syn1		0	--	--	--	--
rs1505229681,2		--	47603332(+)	ATAAAC/TAAACA	5	--	ds5001		0	--	--	--	--
rs1930173161,2		--	47603530(+)	ACCTGC/TAGTCC	5	--	ds5001		0	--	--	--	--
rs1394526681,2		--	47603552(+)	AAGGCA/TGAGGT	5	--	ds5001		0	--	--	--	--
rs108659481,2	C,F,A,H,	--	47603627(+)	AGAGCA/GAGATT	5	--	ds5001		12		NS EA NA	542
rs114568031,2	C,	--	47603925(+)	AAGTAT/-TTTTT	5	--	ut31		1		CSA	2
rs114830551,2	C	--	47603927(+)	TTTTTT/-GCCTC	5	--	ut31		1		NA	2
rs1171124861,2	F,	--	47604008(+)	CAAGAA/CATAGA	5	--	ut31		1		EA	120
rs2010158331,2		--	47604065(+)	TACCCA/CCGCTT	5	--	ut31		0	--	--	--	--
rs1435203741,2	C,	--	47604066(+)	ACCCCC/TGCTTC	5	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for CSPG5 (47603728 - 47622282 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CSPG5: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSPG5

DNA2.0 Custom Variant and Variant Library Synthesis for CSPG5

Disorders / Diseases
for CSPG5 gene

Publications
for CSPG5 gene

PubMed articles for CSPG5 gene, integrated from 9 sources (see all 11): (articles sorted by number of sources associating them with CSPG5)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module. (PubMed id 9950058)^{1, 2, 3, 9} Yasuda Y.... Oohira A. (1998)
2. Neuroglycan C, a novel member of the neuregulin family. (PubMed id 15358134)^{1, 2} Kinugasa Y....Higashiyama S. (2004)
3. CALEB/NGC interacts with the Golgi-associated protein PIST. (PubMed id 12885772)^{1, 2} Hassel B.... Schumacher S. (2003)
4. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)^{1, 9} So H.C....Sham P.C. (2009)
5. Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain. (PubMed id 16299773)^{1, 9} Aono S....Oohira A. (2006)
6. LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)² Halim A.... Nilsson J. (2013)
7. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
8. Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells. (PubMed id 16901907)¹ Ichihara-Tanaka K....Muramatsu T. (2006)
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
10. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)¹ Hartley J.L....Brasch M.A. (2000)

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Products
for CSPG5 gene