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Aliases for CSPG5 Gene

Aliases for CSPG5 Gene

  • Chondroitin Sulfate Proteoglycan 5 (Neuroglycan C) 2 3
  • Acidic Leucine-Rich EGF-Like Domain-Containing Brain Protein 3 4
  • NGC 3 4
  • Chondroitin Sulfate Proteoglycan 5 3
  • Neuroglycan C 4
  • CALEB 4

External Ids for CSPG5 Gene

Previous GeneCards Identifiers for CSPG5 Gene

  • GC03M047401
  • GC03M046808
  • GC03M047564
  • GC03M047578
  • GC03M047603

Summaries for CSPG5 Gene

Entrez Gene Summary for CSPG5 Gene

  • The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for CSPG5 Gene

CSPG5 (Chondroitin Sulfate Proteoglycan 5 (Neuroglycan C)) is a Protein Coding gene. Diseases associated with CSPG5 include spontaneous ocular nystagmus and dengue disease. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include growth factor activity.

UniProtKB/Swiss-Prot for CSPG5 Gene

  • May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.

Gene Wiki entry for CSPG5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSPG5 Gene

Genomics for CSPG5 Gene

Regulatory Elements for CSPG5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CSPG5 Gene

Start:
47,562,238 bp from pter
End:
47,580,792 bp from pter
Size:
18,555 bases
Orientation:
Minus strand

Genomic View for CSPG5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSPG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSPG5 Gene

Proteins for CSPG5 Gene

  • Protein details for CSPG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95196-CSPG5_HUMAN
    Recommended name:
    Chondroitin sulfate proteoglycan 5
    Protein Accession:
    O95196
    Secondary Accessions:
    • Q71M39
    • Q71M40

    Protein attributes for CSPG5 Gene

    Size:
    566 amino acids
    Molecular mass:
    60016 Da
    Quaternary structure:
    • Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC.
    Miscellaneous:
    • Different forms of various molecular weight have been observed. Such forms are possibly due to different levels of glycosylation, phosphorylation and/or protein cleavage (By similarity).

    Alternative splice isoforms for CSPG5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSPG5 Gene

Proteomics data for CSPG5 Gene at MOPED

Post-translational modifications for CSPG5 Gene

  • N-glycosylated.
  • O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissues maturation (By similarity).
  • Phosphorylated; in intracellular and extracellular parts.
  • Glycosylation at Asn57, Ser117, Ser162, Ser165, and Thr328
  • Modification sites at PhosphoSitePlus

Other Protein References for CSPG5 Gene

No data available for DME Specific Peptides for CSPG5 Gene

Domains for CSPG5 Gene

Protein Domains for CSPG5 Gene

Suggested Antigen Peptide Sequences for CSPG5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95196

UniProtKB/Swiss-Prot:

CSPG5_HUMAN :
  • O95196
Domain:
  • Contains 1 EGF-like domain.
genes like me logo Genes that share domains with CSPG5: view

No data available for Gene Families for CSPG5 Gene

Function for CSPG5 Gene

Molecular function for CSPG5 Gene

GENATLAS Biochemistry: neuroglycan,neural transmembrane chondroitin sulfate proteoglycan,brain specific
UniProtKB/Swiss-Prot Function: May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.

Gene Ontology (GO) - Molecular Function for CSPG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12885772
GO:0008083 growth factor activity TAS 12885772
genes like me logo Genes that share ontologies with CSPG5: view

Phenotypes for CSPG5 Gene

genes like me logo Genes that share phenotypes with CSPG5: view

Animal Models for CSPG5 Gene

MGI Knock Outs for CSPG5:

Animal Model Products

miRNA for CSPG5 Gene

miRTarBase miRNAs that target CSPG5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CSPG5 Gene

Localization for CSPG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSPG5 Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=In neurons, localizes to synaptic junctions. Also detected in the endoplasmic reticulum and the Golgi. Partially enriched in lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSPG5 Gene COMPARTMENTS Subcellular localization image for CSPG5 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 5
extracellular 4
lysosome 4
vacuole 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSPG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA 12885772
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with CSPG5: view

Pathways for CSPG5 Gene

genes like me logo Genes that share pathways with CSPG5: view

Pathways by source for CSPG5 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Growth Factors in human,mouse,rat

Gene Ontology (GO) - Biological Process for CSPG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0005975 carbohydrate metabolic process TAS --
GO:0007399 nervous system development TAS 12885772
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
genes like me logo Genes that share ontologies with CSPG5: view

Transcripts for CSPG5 Gene

Unigene Clusters for CSPG5 Gene

Chondroitin sulfate proteoglycan 5 (neuroglycan C):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSPG5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CSPG5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSPG5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5
SP1: - -
SP2: -
SP3: -

Relevant External Links for CSPG5 Gene

GeneLoc Exon Structure for
CSPG5
ECgene alternative splicing isoforms for
CSPG5

Expression for CSPG5 Gene

mRNA expression in normal human tissues for CSPG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSPG5 Gene

This gene is overexpressed in Brain - Amygdala (6.2), Brain - Nucleus accumbens (basal ganglia) (5.4), Brain - Anterior cingulate cortex (BA24) (5.1), Brain - Caudate (basal ganglia) (4.9), Brain - Frontal Cortex (BA9) (4.7), Brain - Putamen (basal ganglia) (4.7), Brain - Cortex (4.5), and Brain - Hippocampus (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CSPG5 Gene

SOURCE GeneReport for Unigene cluster for CSPG5 Gene Hs.45127

mRNA Expression by UniProt/SwissProt for CSPG5 Gene

O95196-CSPG5_HUMAN
Tissue specificity: Restricted to brain (at protein level).
genes like me logo Genes that share expressions with CSPG5: view

In Situ Assay Products

Orthologs for CSPG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CSPG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSPG5 35
  • 99.83 (n)
  • 99.5 (a)
CSPG5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSPG5 35
  • 89.43 (n)
  • 88.39 (a)
CSPG5 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSPG5 35
  • 89.17 (n)
  • 89.6 (a)
CSPG5 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cspg5 35
  • 85.63 (n)
  • 87.16 (a)
Cspg5 16
Cspg5 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSPG5 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cspg5 35
  • 85.45 (n)
  • 87.27 (a)
chicken
(Gallus gallus)
Aves CSPG5 36
  • 40 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9906 35
zebrafish
(Danio rerio)
Actinopterygii cspg5a 36
  • 36 (a)
OneToMany
cspg5b 36
  • 28 (a)
OneToMany
Species with no ortholog for CSPG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CSPG5 Gene

ENSEMBL:
Gene Tree for CSPG5 (if available)
TreeFam:
Gene Tree for CSPG5 (if available)

Paralogs for CSPG5 Gene

No data available for Paralogs for CSPG5 Gene

Variants for CSPG5 Gene

Sequence variations from dbSNP and Humsavar for CSPG5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs869508 -- 47,571,812(+) TCTCT(G/T)GGGTC intron-variant
rs1471711 -- 47,563,008(-) ATGGC(A/C)CAAAT intron-variant
rs1880020 -- 47,576,030(-) AACCC(A/G)GGAGG intron-variant
rs2280567 -- 47,572,923(-) TGTGG(C/T)CGTGG intron-variant
rs3732530 - 47,577,463(+) CTGGC(A/C)CTTGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CSPG5 Gene

Variant ID Type Subtype PubMed ID
nsv428417 CNV Loss 18775914
nsv3807 CNV Insertion 18451855

Relevant External Links for CSPG5 Gene

HapMap Linkage Disequilibrium report
CSPG5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSPG5 Gene

Disorders for CSPG5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CSPG5 Gene including...

Search for CSPG5 Gene in MalaCards »

(3) University of Copenhagen DISEASES for CSPG5 Gene

Relevant External Links for CSPG5

Genetic Association Database (GAD)
CSPG5
Human Genome Epidemiology (HuGE) Navigator
CSPG5
genes like me logo Genes that share disorders with CSPG5: view

No data available for UniProtKB/Swiss-Prot for CSPG5 Gene

Publications for CSPG5 Gene

  1. Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module. (PMID: 9950058) Yasuda Y. … Oohira A. (Neurosci. Res. 1998) 2 3 4 23
  2. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PMID: 19367581) So H.C. … Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 23 48
  3. CALEB/NGC interacts with the Golgi-associated protein PIST. (PMID: 12885772) Hassel B. … Schumacher S. (J. Biol. Chem. 2003) 3 4
  4. Neuroglycan C, a novel member of the neuregulin family. (PMID: 15358134) Kinugasa Y. … Higashiyama S. (Biochem. Biophys. Res. Commun. 2004) 3 4
  5. Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain. (PMID: 16299773) Aono S. … Oohira A. (J. Neurosci. Res. 2006) 3 23

Products for CSPG5 Gene

Sources for CSPG5 Gene

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