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CSPG5 Gene

protein-coding   GIFtS: 58
GCID: GC03M047603

Chondroitin Sulfate Proteoglycan 5 (Neuroglycan C)

  See CSPG5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chondroitin Sulfate Proteoglycan 5 (Neuroglycan C)1 2
Acidic Leucine-Rich EGF-Like Domain-Containing Brain Protein2 3
NGC2 3
Chondroitin Sulfate Proteoglycan 52
CALEB3
Neuroglycan C3

External Ids:    HGNC: 24671   Entrez Gene: 106752   Ensembl: ENSG000001146467   OMIM: 6067755   UniProtKB: O951963   

Export aliases for CSPG5 gene to outside databases

Previous GC identifers: GC03M047401 GC03M046808 GC03M047564 GC03M047578


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSPG5 Gene:
The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation
factor. Several transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, May 2011)

GeneCards Summary for CSPG5 Gene:
CSPG5 (chondroitin sulfate proteoglycan 5 (neuroglycan C)) is a protein-coding gene. Diseases associated with CSPG5 include spontaneous ocular nystagmus, and dengue disease. GO annotations related to this gene include growth factor activity.

UniProtKB/Swiss-Prot: CSPG5_HUMAN, O95196
Function: May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3
activation

Gene Wiki entry for CSPG5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSPG5 gene promoter:
         GR   GR-beta   SREBP-1c   MIF-1   HNF-1A   Arnt   SREBP-1b   CREB   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSPG5 promoter sequence
   Search Chromatin IP Primers for CSPG5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSPG5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

CSPG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSPG5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M047603:  view genomic region     (about GC identifiers)

Start:
47,603,728 bp from pter      End:
47,622,282 bp from pter
Size:
18,555 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CSPG5_HUMAN, O95196 (See protein sequence)
Recommended Name: Chondroitin sulfate proteoglycan 5 precursor  
Size: 566 amino acids; 60016 Da
Subunit: Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC
Developmental stage: Expressed in brain of 3 months, 5 and 10-year-old individuals
Miscellaneous: Different forms of various molecular weight have been observed. Such forms are possibly due to
different levels of glycosylation, phosphorylation and/or protein cleavage (By similarity)
Secondary accessions: Q71M39 Q71M40
Alternative splicing: 3 isoforms:  O95196-1   O95196-2   O95196-3   

Explore the universe of human proteins at neXtProt for CSPG5: NX_O95196

Explore proteomics data for CSPG5 at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan
    exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms
    depends on tissues and tissues maturation (By similarity)1
  • Phosphorylated; in intracellular and extracellular parts (By similarity)1
  • Glycosylation2 at Asn57, Ser117, Ser162, Ser165, Thr328
  • Modification sites at PhosphoSitePlus

  • See CSPG5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001193871.1  NP_001193872.1  NP_001193873.1  NP_001193874.1  NP_006565.2  

    ENSEMBL proteins: 
     ENSP00000392096   ENSP00000373244   ENSP00000264723  
    Reactome Protein details: O95196

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR009505 Neural_ProG_Cyt
     IPR010555 Chon_Sulph_att

    Graphical View of Domain Structure for InterPro Entry O95196

    ProtoNet protein and cluster: O95196

    UniProtKB/Swiss-Prot: CSPG5_HUMAN, O95196
    Similarity: Contains 1 EGF-like domain


    Find genes that share domains with CSPG5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSPG5_HUMAN, O95196
    Function: May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3
    activation

         Genatlas biochemistry entry for CSPG5:
    neuroglycan,neural transmembrane chondroitin sulfate proteoglycan,brain specific

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12885772
    GO:0008083growth factor activity TAS12885772
         
    Find genes that share ontologies with CSPG5           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cspg5):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with CSPG5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cspg5tm1Fgr for CSPG5

       genOway: Develop your customized and physiologically relevant rodent model for CSPG5

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    miRTarBase miRNAs that target CSPG5:
    hsa-mir-92a-3p (MIRT049719), hsa-mir-26b-5p (MIRT029790), hsa-mir-3691-5p (MIRT052881)

    Block miRNA regulation of human, mouse, rat CSPG5 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CSPG5:
    hsa-miR-223 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-548k hsa-miR-3613-3p hsa-miR-486-5p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CSPG5_HUMAN, O95196: Cell membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum
    membrane; Single-pass type I membrane protein (By similarity). Golgi apparatus membrane; Single-pass type I
    membrane protein (By similarity). Note=In neurons, localizes to synaptic junctions (By similarity). Also detected
    in the endoplasmic reticulum and the Golgi (By similarity). Partially enriched in lipid rafts (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    plasma membrane5
    extracellular4
    lysosome4
    vacuole4
    nucleus2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005794Golgi apparatus IDA12885772
    GO:0005796Golgi lumen TAS--
    GO:0005887integral component of plasma membrane TAS9950058

    Find genes that share ontologies with CSPG5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSPG5 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    CS/DS degradation0.00
    A tetrasaccharide linker sequence is required for GAG synthesis0.51
    Dermatan sulfate biosynthesis0.00
    Chondroitin sulfate biosynthesis0.41
    3Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    4Metabolism
    Metabolism0.38
    5Disease
    Disease


    Find genes that share SuperPaths with CSPG5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Reactome Pathways for CSPG5
        Dermatan sulfate biosynthesis
    CS/DS degradation
    A tetrasaccharide linker sequence is required for GAG synthesis
    Chondroitin sulfate biosynthesis


        Pathway & Disease-focused RT2 Profiler PCR Array including CSPG5: 
              Growth Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CSPG5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSPG5 (O951961, 3 ENSP000002647234) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOPCQ9HD263, ENSP000003574844I2D: score=2 STRING: ENSP00000357484
    YWHABP319463I2D: score=1 
    AGRNENSP000003686784STRING: ENSP00000368678
    BCANENSP000003312104STRING: ENSP00000331210
    BGNENSP000003273364STRING: ENSP00000327336
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007399nervous system development TAS12885772
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--
    GO:0030206chondroitin sulfate biosynthetic process TAS--

    Find genes that share ontologies with CSPG5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CSPG5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CSPG5 gene (5 alternative transcripts): 
    NM_001206942.1  NM_001206943.1  NM_001206944.1  NM_001206945.1  NM_006574.3  

    Unigene Cluster for CSPG5:

    Chondroitin sulfate proteoglycan 5 (neuroglycan C)
    Hs.45127  [show with all ESTs]
    Unigene Representative Sequence: AF461089
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456150(uc003crn.3) ENST00000383738(uc003crp.4 uc011bbb.2)
    ENST00000264723(uc003cro.4 uc021wxh.1 uc021wxi.1) ENST00000465441

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    SwitchGear 3'UTR luciferase reporter plasmidCSPG5 3' UTR sequence
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    Additional mRNA sequence: 

    AF059274.1 AF461087.1 AF461088.1 AF461089.1 AK094639.1 AK294621.1 

    5 DOTS entries:

    DT.210059  DT.102821884  DT.102821885  DT.40210091  DT.95329623 

    Selected AceView cDNA sequences (see all 62):

    AF461088 BM713282 AV706863 BM701174 BF525413 AI369838 BU732090 AF461087 
    AV705054 BM701212 AF461089 NM_006574 AV703143 BM708322 BM676397 AI492262 
    BM718452 AI653158 BU738793 CA440369 BM722719 BM683500 BM715682 AW071879 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CSPG5    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5
    SP1:        -                       -         
    SP2:        -                                 
    SP3:                                -         


    ECgene alternative splicing isoforms for CSPG5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSPG5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTATGTA
    CSPG5 Expression
    About this image


    CSPG5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Eye (Sensory Organs)
     
     Spinal Cord (Nervous System)
    CSPG5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSPG5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.45127

    UniProtKB/Swiss-Prot: CSPG5_HUMAN, O95196
    Tissue specificity: Restricted to brain (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including CSPG5: 
              Growth Factors in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSPG5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CSPG5 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cspg51 , 5 chondroitin sulfate proteoglycan 51, 5 85.63(n)1
    87.16(a)1
      9 (59.89 cM)5
    298731  NM_001166273.11  NP_001159745.11 
     1102437835 
    chicken
    (Gallus gallus)
    Aves CSPG56
    chondroitin sulfate proteoglycan 5 precursor
    40(a)
    1 ↔ 1
    2(836597-844877)
    zebrafish
    (Danio rerio)
    Actinopterygii cspg5a6
    cspg5b6
    chondroitin sulfate proteoglycan 5b
    36(a)
    28(a)
    many → 1
    many → 1
    16(45093086-45161600) ENSDARG00000069981
    19(18859894-18921149) ENSDARG00000070863


    ENSEMBL Gene Tree for CSPG5 (if available)
    TreeFam Gene Tree for CSPG5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSPG5 (see all 351)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1840434601,2
    Cuntested184875174(+) AGGACA/GAGGGC 10 L syn10--------
    rs114568031,2
    C--47603926(+) TTTTTT/-GCCTC 5 -- ut312Minor allele frequency- -:0.25NA CSA 4
    rs613298741,2
    C--47607157(+) GTAGG-/AAAGAGT 5 -- int10--------
    rs113302631,2
    C,F--47607172(+) ATAGGA/-AAAAA 5 -- int1 trp33Minor allele frequency- -:0.50NA CSA 6
    rs360309461,2
    C--47611760(+) TTTTT-/TGTAAA 5 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs712818991,2
    C--47612004(-) GTCTC-/AAAAAA 5 -- int11Minor allele frequency- A:0.50NA 2
    rs1389351671,2
    C--47612585(+) AAATT-/AATAAAA 5 -- int10--------
    rs622607491,2
    C,F--47649158(+) AGATCA/GCGCCA 5 -- ds50012Minor allele frequency- G:0.33NA 6
    rs1505229681,2
    --47649213(+) ATAAAC/TAAACA 5 -- ds50010--------
    rs1930173161,2
    --47649411(+) ACCTGC/TAGTCC 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for CSPG5 (47603728 - 47622282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CSPG5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3807CNV Insertion18451855
    nsv428417CNV Loss18775914

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606775    OMIM disorders: --

    2 diseases for CSPG5:    
    About MalaCards
    spontaneous ocular nystagmus    dengue disease

    3 diseases from the University of Copenhagen DISEASES database for CSPG5:
    Spontaneous ocular nystagmus     Dengue disease     Yellow fever

    Find genes that share disorders with CSPG5           About GenesLikeMe

    Genetic Association Database (GAD): CSPG5
    Human Genome Epidemiology (HuGE) Navigator: CSPG5 (1 document)

    Export disorders for CSPG5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSPG5 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CSPG5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module. (PubMed id 9950058)1, 2, 3, 9 Yasuda Y.... Oohira A. (Neurosci. Res. 1998)
    2. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4, 9 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Neuroglycan C, a novel member of the neuregulin family. (PubMed id 15358134)1, 2 Kinugasa Y....Higashiyama S. (Biochem. Biophys. Res. Commun. 2004)
    4. CALEB/NGC interacts with the Golgi-associated protein PIST. (PubMed id 12885772)1, 2 Hassel B.... Schumacher S. (J. Biol. Chem. 2003)
    5. Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain. (PubMed id 16299773)1, 9 Aono S....Oohira A. (J. Neurosci. Res. 2006)
    6. LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)2 Halim A.... Nilsson J. (J. Proteome Res. 2013)
    7. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    8. Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells. (PubMed id 16901907)1 Ichihara-Tanaka K....Muramatsu T. (J. Biol. Chem. 2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (Genome Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10675 HGNC: 2467 AceView: CSPG5 Ensembl:ENSG00000114646 euGenes: HUgn10675
    ECgene: CSPG5 H-InvDB: CSPG5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CSPG5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CSPG5 gene:
    Search GeneIP for patents involving CSPG5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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