Aliases for CSPG4 Gene
Aliases for CSPG4 Gene
External Ids for CSPG4 Gene
- HGNC: 2466
- Entrez Gene: 1464
- Ensembl: ENSG00000173546
- OMIM: 601172
- UniProtKB: Q6UVK1
Previous GeneCards Identifiers for CSPG4 Gene
- GC15M071843
- GC15M069056
- GC15M073542
- GC15M073682
- GC15M073754
- GC15M075966
- GC15M052722
Summaries for CSPG4 Gene
-
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for CSPG4 Gene
CSPG4 (Chondroitin Sulfate Proteoglycan 4) is a Protein Coding gene. Diseases associated with CSPG4 include Melanoma and Demyelinating Disease. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include protein kinase binding and signal transducer activity. An important paralog of this gene is FREM2.
UniProtKB/Swiss-Prot for CSPG4 Gene
-
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSPG4 Gene
Genomics for CSPG4 Gene
Regulatory Elements for CSPG4 Gene
Enhancers for CSPG4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CSPG4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CSPG4 gene promoter:
Regulatory Element Products
Genomic Location for CSPG4 Gene
- Chromosome:
- 15
- Start:
- 75,674,322 bp from pter
- End:
- 75,712,848 bp from pter
- Size:
- 38,527 bases
- Orientation:
- Minus strand
Genomic View for CSPG4 Gene
Genes around CSPG4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.2 by Ensembl
- 15q24.2 by Entrez Gene
- 15q24.2 by HGNC
CSPG4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CSPG4 Gene
Proteins for CSPG4 Gene
-
Protein details for CSPG4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UVK1-CSPG4_HUMAN
- Recommended name:
- Chondroitin sulfate proteoglycan 4
- Protein Accession:
- Q6UVK1
- D3DW77
- Q92675
Protein attributes for CSPG4 Gene
- Size:
- 2322 amino acids
- Molecular mass:
- 250537 Da
- Quaternary structure:
-
- Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2 (By similarity). Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16.
- Miscellaneous:
-
- Valuable marker for several incompletely differentiated precursor cells.
Protein Expression for CSPG4 Gene
Selected DME Specific Peptides for CSPG4 Gene
- Q6UVK1:
-
- LGRSSLS
- PLVVAEG
Post-translational modifications for CSPG4 Gene
- O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4.
- Phosphorylation by PRKCA regulates its subcellular location and function in cell motility.
- Glycosylation at isoforms=130, isoforms=348, isoforms=427, isoforms=685, Asn772, Ser995, isoforms=1131, Asn1202, isoforms=1364, isoforms=1449, isoforms=1645, Asn1909, Asn2016, Asn2034, isoforms=2040, and isoforms=2075
- Modification sites at PhosphoSitePlus
Other Protein References for CSPG4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top CSPG4 Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CSPG4
- R&D Systems Antibodies for CSPG4 (NG2/MCSP)
- Cell Signaling Technology (CST) Antibodies for CSPG4 (NG2)
- Novus Biologicals Antibodies for CSPG4
-
Cloud-Clone Corp. Antibodies for CSPG4
- Invitrogen Antibodies for CSPG4
- antibodies-online Antibodies for CSPG4: See all 99
- GeneTex CSPG4 antibody for CSPG4
-
Santa Cruz Biotechnology (SCBT) Antibodies for CSPG4
Protein Products
- R&D Systems Proteins and Enzymes for CSPG4 (NG2/MCSP)
-
OriGene Purified Proteins for CSPG4
- Search Origene for MassSpec and Protein Over-expression Lysates for CSPG4
- Origene Custom Protein Services for CSPG4
- Novus Biologicals proteins for CSPG4
-
Cloud-Clone Corp. Proteins for CSPG4
- antibodies-online Proteins for CSPG4: See all 12
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CSPG4
Domains & Families for CSPG4 Gene
Gene Families for CSPG4 Gene
- HGNC:
Protein Domains for CSPG4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CSPG4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CSPG4 Gene
Function for CSPG4 Gene
Molecular function for CSPG4 Gene
- UniProtKB/Swiss-Prot Function:
- Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004871 | signal transducer activity | IEA | -- |
| GO:0019901 | protein kinase binding | IPI | 10587647 |
Phenotypes for CSPG4 Gene
- MGI mutant phenotypes for CSPG4:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for CSPG4:
Animal Models for CSPG4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CSPG4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CSPG4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CSPG4 gene
- Search ViGene Biosciences for CSPG4
CRISPR Products
-
OriGene CRISPR knockouts for CSPG4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSPG4
- GenScript: Design CRISPR guide RNA sequences for CSPG4
miRNA for CSPG4 Gene
- miRTarBase miRNAs that target CSPG4
miRNA Products
- Search ViGene Biosciences for CSPG4
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for CSPG4
- Browse OriGene Inhibitory RNA Products For CSPG4
-
ViGene Biosciences ready-to-package AAV shRNAs for CSPG4 gene
Clone Products
-
OriGene ORF clones in human for CSPG4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CSPG4
- VectorBuilder custom plasmid, inducible vectors for CSPG4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSPG4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CSPG4
-
ViGene Biosciences adenoviral particle packaged cDNA for CSPG4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CSPG4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CSPG4 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSPG4 Gene
Localization for CSPG4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CSPG4 Gene
- Cell membrane; Single-pass type I membrane protein; Extracellular side. Apical cell membrane; Single-pass type I membrane protein; Extracellular side. Cell projection, lamellipodium membrane; Single-pass type I membrane protein; Extracellular side. Cell surface. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity). {ECO:0000250 UniProtKB:Q00657, ECO:0000250 UniProtKB:Q8VHY0}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| lysosome | 5 |
| golgi apparatus | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8790396 |
| GO:0005925 | focal adhesion | IDA | 21423176 |
Pathways & Interactions for CSPG4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chondroitin sulfate/dermatan sulfate metabolism | ||
| 2 | Glycosaminoglycan metabolism | ||
| 3 | Neuroscience | ||
| 4 | Wnt / Hedgehog / Notch | ||
| 5 | Neural Stem Cell Differentiation Pathways and Lineage-specific Markers | ||
Pathways by source for CSPG4 Gene
2 Cell Signaling Technology pathways for CSPG4 Gene
1 BioSystems pathway for CSPG4 Gene
1 GeneGo (Thomson Reuters) pathway for CSPG4 Gene
1 R&D Systems pathway for CSPG4 Gene
Interacting Proteins for CSPG4 Gene
Selected Interacting proteins:
Q6UVK1-CSPG4_HUMAN
ENSP00000312506
for CSPG4 Gene via
MINT
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IEA | -- |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for SIGNOR curated interactions for CSPG4 Gene
Drugs & Compounds for CSPG4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Chondroitin sulfate | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CSPG4 Gene
mRNA/cDNA for CSPG4 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (117) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CSPG4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CSPG4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSPG4
- GenScript: Design CRISPR guide RNA sequences for CSPG4
miRNA Products
- Search ViGene Biosciences for CSPG4
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for CSPG4
- Browse OriGene Inhibitory RNA Products For CSPG4
-
ViGene Biosciences ready-to-package AAV shRNAs for CSPG4 gene
Clone Products
-
OriGene ORF clones in human for CSPG4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CSPG4
- VectorBuilder custom plasmid, inducible vectors for CSPG4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSPG4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CSPG4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Oligodendrocyte Precursor Cells Lateral Ganglionic Eminence
- Oligodendrocyte Precursor Cells dP3 Neural Domain
- Oligodendrocyte Precursor Cells Caudal Ganglionic Eminence
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Oligodendrocyte Precursor Cells dP5 Neural Domain
- Cartilage (Muscoskeletal System)
-
Neural Tube (Nervous System)
- Oligodendrocyte Precursor Cells Lateral Ganglionic Eminence
- Oligodendrocyte Precursor Cells dP3 Neural Domain
- Oligodendrocyte Precursor Cells Caudal Ganglionic Eminence
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Oligodendrocyte Precursor Cells dP5 Neural Domain
- Bone (Muscoskeletal System)
-
Spinal Cord (Nervous System)
- Oligodendrocyte Precursor Cells Spinal Cord White Matter
- Oligodendrocyte progenitor cells(Najm FJ et. al. 2011)
- Oligodendrocyte progenitor-like cells(Keirstead HS et. al. 2005)
- B27-induced oligodendrocyte-like cells(Sundberg M et. al. 2010)
- Expanded oligodendrocyte progenitor cells(Najm FJ et. al. 2011)
- Glial Cells
-
Peripheral Nervous System (Nervous System)
- Pro-myelinating Schwann Cells Peripheral Nerve Domain
- Non-myelinating Schwann Cells Peripheral Nerve Domain
- Immature Schwann Cells Peripheral Nerve Domain
- Schwann cells
- Oligodendrocytes (Nervous System)
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Renal Vesicle
- S-shaped Body
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
- Hair follicle stem cells
-
Lung (Respiratory System)
- Chondrocytes Tracheal Cartilage
- Tracheal Cartilage
-
Endothelium (Cardiovascular System)
- Mesenchymal Stem Cells Microvessels
- Pericytes Microvessels
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Microvessels
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Pericytes Splanchnic Mesoderm
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Ovary (Reproductive System)
- Blood (Hematopoietic System)
- NULL (Uncategorized)
- Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for CSPG4 Gene
This gene is overexpressed in Artery - Tibial (x7.1), Artery - Aorta (x4.8), and Artery - Coronary (x4.4).
This gene is overexpressed in Esophagus (7.2), Placenta (6.7), and Uterus (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSPG4 Gene
NURSA nuclear receptor signaling pathways regulating expression of CSPG4 Gene:
CSPG4SOURCE GeneReport for Unigene cluster for CSPG4 Gene:
Hs.513044mRNA Expression by UniProt/SwissProt for CSPG4 Gene:
Q6UVK1-CSPG4_HUMAN
Tissue specificity:
Detected only in malignant melanoma cells.
Evidence on tissue expression from TISSUES for CSPG4 Gene
- Bone marrow(4.1)
- Liver(3.8)
- Nervous system(3)
- Skin(2.9)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for CSPG4
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CSPG4 Gene
Orthologs for CSPG4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CSPG4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CSPG4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Cspg4 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CSPG4 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cspg4 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CSPG4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | CSPG4 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CSPG4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101733782 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cspg4 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | kon 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | C48E7.6 36 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for CSPG4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CSPG4 Gene
(1) SIMAP similar genes for CSPG4 Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for CSPG4 Gene
Variants for CSPG4 Gene
| SNP ID | Clin | Chr 15 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000106936 | -- | 75,709,006(+) | GCAGG(A/T)CTAAC | intron-variant | |
| rs1000269184 | -- | 75,703,294(+) | GAGCG(A/G)GATGG | intron-variant | |
| rs1000533353 | -- | 75,693,079(+) | AGGCG(G/T)CCAGA | reference, synonymous-codon | |
| rs1000703405 | -- | 75,702,897(+) | CCCTG(C/T)CCGCC | intron-variant | |
| rs1000881475 | -- | 75,682,120(+) | CCCTG(C/T)CAGCC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2667001 | CNV | deletion | 23128226 |
| esv2749894 | CNV | deletion | 23290073 |
| esv2749895 | CNV | deletion | 23290073 |
| nsv1116463 | OTHER | inversion | 24896259 |
| nsv527186 | CNV | loss | 19592680 |
| nsv569997 | CNV | loss | 21841781 |
| nsv951997 | CNV | deletion | 24416366 |
| nsv984092 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.72;
93.28% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CSPG4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CSPG4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSPG4 Gene
Disorders for CSPG4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melanoma |
|
|
| demyelinating disease |
|
Search CSPG4 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CSPG4
No data available for UniProtKB/Swiss-Prot and Genatlas for CSPG4 Gene
Publications for CSPG4 Gene
- NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. (PMID: 15181153) Fukushi J. … Stallcup W.B. (Mol. Biol. Cell 2004) 3 4 22 64
- A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family. (PMID: 12220645) Staub E. … Rosenthal A. (FEBS Lett. 2002) 3 4 22 64
- Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan. (PMID: 8790396) Pluschke G. … Reisfeld R.A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 64
- Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP. (PMID: 19776755) Giangreco A. … Watt F.M. (J. Invest. Dermatol. 2010) 3 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
Products for CSPG4 Gene
- R&D Systems Antibodies for CSPG4 (NG2/MCSP)
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- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CSPG4
- Novus Biologicals proteins for CSPG4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for CSPG4
- Cloud-Clone Corp. Proteins for CSPG4
- Cloud-Clone Corp Assay Kits for CSPG4
- Addgene plasmids for CSPG4
- antibodies-online Antibodies for CSPG4: See all 99
- antibodies-online Kits for CSPG4: See all 13
- antibodies-online Proteins for CSPG4: See all 12
- Search antibodies-online for peptides
- GeneTex CSPG4 antibody for CSPG4
- Search GeneTex for Proteins for CSPG4
- ViGene Biosciences adenoviral particle packaged cDNA for CSPG4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CSPG4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CSPG4 gene
- Search ViGene Biosciences for CSPG4
- Santa Cruz Biotechnology (SCBT) Antibodies for CSPG4
- Search Santa Cruz Biotechnology (SCBT) for CSPG4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CSPG4
- Horizon Cell Lines for CSPG4
- Cyagen custom Knockout/knockin (KOKI) mouse models for CSPG4
- VectorBuilder custom plasmid, inducible vectors for CSPG4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSPG4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CSPG4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer