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Aliases for CSPG4 Gene

Aliases for CSPG4 Gene

  • Chondroitin Sulfate Proteoglycan 4 2 3
  • Melanoma-Associated Chondroitin Sulfate Proteoglycan 2 3 4
  • Chondroitin Sulfate Proteoglycan 4 (Melanoma-Associated) 2 3
  • Melanoma Chondroitin Sulfate Proteoglycan 3 4
  • Chondroitin Sulfate Proteoglycan NG2 3 4
  • MCSPG 3 6
  • MSK16 3 6
  • MCSP 3 4
  • NG2 3 6
  • MEL-CSPG 3
  • EC 2.7.8 63
  • EC 3.6.3 63
  • HMW-MAA 3

External Ids for CSPG4 Gene

Previous GeneCards Identifiers for CSPG4 Gene

  • GC15M071843
  • GC15M069056
  • GC15M073542
  • GC15M073682
  • GC15M073754
  • GC15M075966
  • GC15M052722

Summaries for CSPG4 Gene

Entrez Gene Summary for CSPG4 Gene

  • A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSPG4 Gene

CSPG4 (Chondroitin Sulfate Proteoglycan 4) is a Protein Coding gene. Diseases associated with CSPG4 include melanoma and acral lentiginous melanoma. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include protein kinase binding and signal transducer activity. An important paralog of this gene is FREM3.

UniProtKB/Swiss-Prot for CSPG4 Gene

  • Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

Gene Wiki entry for CSPG4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSPG4 Gene

Genomics for CSPG4 Gene

Regulatory Elements for CSPG4 Gene

Genomic Location for CSPG4 Gene

Start:
75,674,322 bp from pter
End:
75,712,848 bp from pter
Size:
38,527 bases
Orientation:
Minus strand

Genomic View for CSPG4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSPG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSPG4 Gene

Proteins for CSPG4 Gene

  • Protein details for CSPG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UVK1-CSPG4_HUMAN
    Recommended name:
    Chondroitin sulfate proteoglycan 4
    Protein Accession:
    Q6UVK1
    Secondary Accessions:
    • D3DW77
    • Q92675

    Protein attributes for CSPG4 Gene

    Size:
    2322 amino acids
    Molecular mass:
    250537 Da
    Quaternary structure:
    • Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2 (By similarity). Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16.
    Miscellaneous:
    • Valuable marker for several incompletely differentiated precursor cells

neXtProt entry for CSPG4 Gene

Proteomics data for CSPG4 Gene at MOPED

Selected DME Specific Peptides for CSPG4 Gene

Post-translational modifications for CSPG4 Gene

  • O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4.
  • Phosphorylation by PRKCA regulates its subcellular location and function in cell motility.
  • Glycosylation at Asn130, Asn348, Asn427, Asn685, Asn772, Ser995, Asn1131, Asn1202, Asn1364, Asn1449, Asn1645, Asn1909, Asn2016, Asn2034, Asn2040, and Asn2075
  • Modification sites at PhosphoSitePlus

Other Protein References for CSPG4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CSPG4 Gene

Gene Families for CSPG4 Gene

HGNC:
  • CSPG :Proteoglycans / Cell surface : Other

Protein Domains for CSPG4 Gene

Suggested Antigen Peptide Sequences for CSPG4 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UVK1

UniProtKB/Swiss-Prot:

CSPG4_HUMAN :
  • Q6UVK1
Domain:
  • Contains 2 laminin G-like domains.
Similarity:
  • Contains 15 CSPG (NG2) repeats.
genes like me logo Genes that share domains with CSPG4: view

Function for CSPG4 Gene

Molecular function for CSPG4 Gene

UniProtKB/Swiss-Prot Function: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

Enzyme Numbers (IUBMB) for CSPG4 Gene

Gene Ontology (GO) - Molecular Function for CSPG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding --
GO:0019901 protein kinase binding IPI 10587647
genes like me logo Genes that share ontologies with CSPG4: view
genes like me logo Genes that share phenotypes with CSPG4: view

Animal Models for CSPG4 Gene

MGI Knock Outs for CSPG4:

Animal Model Products

CRISPR Products

miRNA for CSPG4 Gene

miRTarBase miRNAs that target CSPG4

No data available for Transcription Factor Targeting and HOMER Transcription for CSPG4 Gene

Localization for CSPG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSPG4 Gene

Apical cell membrane; Single-pass type I membrane protein; Extracellular side. Cell projection, lamellipodium membrane; Single-pass type I membrane protein; Extracellular side. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSPG4 Gene COMPARTMENTS Subcellular localization image for CSPG4 gene
Compartment Confidence
plasma membrane 5
extracellular 4
golgi apparatus 4
lysosome 4
vacuole 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CSPG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane TAS 8790396
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CSPG4: view

Pathways for CSPG4 Gene

genes like me logo Genes that share pathways with CSPG4: view

Pathways by source for CSPG4 Gene

2 Cell Signaling Technology pathways for CSPG4 Gene
1 BioSystems pathway for CSPG4 Gene

Gene Ontology (GO) - Biological Process for CSPG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0001525 angiogenesis IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with CSPG4: view

Compounds for CSPG4 Gene

(1) HMDB Compounds for CSPG4 Gene

Compound Synonyms Cas Number PubMed IDs
Chondroitin sulfate
  • Chondritinsulfate
9007-28-7

(3) Novoseek inferred chemical compound relationships for CSPG4 Gene

Compound -log(P) Hits PubMed IDs
chondroitin sulfate 43.3 5
glycosaminoglycan 38.1 2
glutamate 0.0307 2
genes like me logo Genes that share compounds with CSPG4: view

Transcripts for CSPG4 Gene

mRNA/cDNA for CSPG4 Gene

(117) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSPG4 Gene

Chondroitin sulfate proteoglycan 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSPG4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CSPG4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSPG4 Gene

No ASD Table

Relevant External Links for CSPG4 Gene

GeneLoc Exon Structure for
CSPG4
ECgene alternative splicing isoforms for
CSPG4

Expression for CSPG4 Gene

mRNA expression in normal human tissues for CSPG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSPG4 Gene

This gene is overexpressed in Artery - Tibial (7.1), Artery - Aorta (4.8), and Artery - Coronary (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSPG4 Gene

SOURCE GeneReport for Unigene cluster for CSPG4 Gene Hs.513044

mRNA Expression by UniProt/SwissProt for CSPG4 Gene

Q6UVK1-CSPG4_HUMAN
Tissue specificity: Detected only in malignant melanoma cells.
genes like me logo Genes that share expressions with CSPG4: view

In Situ Assay Products

Orthologs for CSPG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSPG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSPG4 35
  • 98.38 (n)
  • 98.54 (a)
CSPG4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSPG4 35
  • 86.7 (n)
  • 87.15 (a)
CSPG4 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSPG4 35
  • 82.8 (n)
  • 82.98 (a)
CSPG4 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cspg4 35
  • 83.02 (n)
  • 83.55 (a)
Cspg4 16
Cspg4 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSPG4 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cspg4 35
  • 82.74 (n)
  • 83.29 (a)
chicken
(Gallus gallus)
Aves CSPG4 35
  • 60.68 (n)
  • 51.32 (a)
CSPG4 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSPG4 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733782 35
  • 48.35 (n)
  • 39.42 (a)
zebrafish
(Danio rerio)
Actinopterygii cspg4 35
  • 48.05 (n)
  • 37.67 (a)
cspg4 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta kon 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C48E7.6 36
  • 20 (a)
OneToOne
C48E7.6 37
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for CSPG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSPG4 Gene

ENSEMBL:
Gene Tree for CSPG4 (if available)
TreeFam:
Gene Tree for CSPG4 (if available)

Paralogs for CSPG4 Gene

Paralogs for CSPG4 Gene

Selected SIMAP similar genes for CSPG4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CSPG4: view

Variants for CSPG4 Gene

Sequence variations from dbSNP and Humsavar for CSPG4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1127646 -- 75,675,473(-) ATGCC(C/T)GGTGC utr-variant-3-prime
rs1127647 -- 75,675,115(-) TTTTC(C/T)ACTCC utr-variant-3-prime
rs1127648 -- 75,674,754(-) GCAGG(C/T)TAGGC utr-variant-3-prime
rs1127649 -- 75,674,713(-) CACTG(C/G/T)GGTGC utr-variant-3-prime
rs1127650 -- 75,674,712(-) ACTGC(A/G)GTGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CSPG4 Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV Deletion 23290073
esv2749895 CNV Deletion 23290073
nsv527186 CNV Loss 19592680
dgv2415n71 CNV Loss 21882294
dgv2416n71 CNV Loss 21882294
nsv904395 CNV Loss 21882294
esv2667001 CNV Deletion 23128226

Relevant External Links for CSPG4 Gene

HapMap Linkage Disequilibrium report
CSPG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSPG4 Gene

Disorders for CSPG4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CSPG4 Gene including...

Search for CSPG4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CSPG4 Gene

(9) Novoseek inferred disease relationships for CSPG4 Gene

Disease -log(P) Hits PubMed IDs
glioma 43.7 12
melanoma 36.2 9
demyelinating diseases 33.3 1
minimal residual disease 33.1 1
demyelination 22.2 1

Relevant External Links for CSPG4

Genetic Association Database (GAD)
CSPG4
Human Genome Epidemiology (HuGE) Navigator
CSPG4
genes like me logo Genes that share disorders with CSPG4: view

No data available for UniProtKB/Swiss-Prot for CSPG4 Gene

Publications for CSPG4 Gene

  1. A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family. (PMID: 12220645) Staub E. … Rosenthal A. (FEBS Lett. 2002) 3 4 23
  2. NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. (PMID: 15181153) Fukushi J. … Stallcup W.B. (Mol. Biol. Cell 2004) 3 4 23
  3. Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan. (PMID: 8790396) Pluschke G. … Reisfeld R.A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4
  4. Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility. (PMID: 15504744) Makagiansar I.T. … Stallcup W.B. (J. Biol. Chem. 2004) 3 23
  5. Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. (PMID: 11278606) Iida J. … McCarthy J.B. (J. Biol. Chem. 2001) 3 4

Products for CSPG4 Gene

Sources for CSPG4 Gene

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