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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSPG4 Gene

protein-coding   GIFtS: 65
GCID: GC15M075966

chondroitin sulfate proteoglycan 4

(Previous name: chondroitin sulfate proteoglycan 4 (melanoma-associated)...)
 Explore 21 diseases affiliated with
CSPG4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CSPG4    

Aliases
for CSPG4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chondroitin Sulfate Proteoglycan 41 2     Chondroitin Sulfate Proteoglycan 4 (Melanoma-Associated)1 2
MCSP1 2 3     Chondroitin Sulfate Proteoglycan NG22 3
MCSPG1 2 5     Melanoma Chondroitin Sulfate Proteoglycan2 3
MSK161 2 5     Melanoma-Associated Chondroitin Sulfate Proteoglycan2 3
NG21 2 5     EC 2.7.88
HMW-MAA1 2     EC 3.6.38
MEL-CSPG1 2     

External Ids:    HGNC: 24661   Entrez Gene: 14642   Ensembl: ENSG000001735467   OMIM: 6011725   UniProtKB: Q6UVK13   

Export aliases for CSPG4 gene to outside databases

Previous GC identifers: GC15M071843 GC15M069056 GC15M073542 GC15M073682 GC15M073754 GC15M052722


Summaries
for CSPG4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CSPG4:
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions
during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral
membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CSPG4_HUMAN, Q6UVK1
Function: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility
during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon
regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that
substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their
activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells
invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting
angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding
and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation.
May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling
cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades

Gene Wiki entry for CSPG4


Genomic Views
for CSPG4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSPG4 gene promoter:
         HFH-3   HTF   Lmo2   Pax-2   Pax-2a   Nkx5-1   NF-kappaB   YY1   FOXI1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CSPG4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CSPG4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSPG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q24.2

CSPG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSPG4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M075966:  view genomic region     (about GC identifiers)

Start:
 75,966,663 bp from pter      End:
 76,005,189 bp from pter
Size:
 38,527 bases      Orientation:
 minus strand

Proteins
for CSPG4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CSPG4_HUMAN, Q6UVK1 (See protein sequence)
Recommended Name: Chondroitin sulfate proteoglycan 4 precursor  
Size: 2322 amino acids; 250537 Da
Subunit: Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2.
Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary
complex with GRIP1 and GRIA2 (By similarity). Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3.
Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1.
Interacts with MMP16
Subcellular location: Apical cell membrane; Single-pass type I membrane protein; Extracellular side (By similarity).
Cell projection, lamellipodium membrane; Single-pass type I membrane protein; Extracellular side (By similarity).
Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by
PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity)
Miscellaneous: Valuable marker for several incompletely differentiated precursor cells
Secondary accessions: D3DW77 Q92675

Explore the universe of human proteins at neXtProt for CSPG4: NX_Q6UVK1

Post-translational modifications:

  • O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function
    • in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA41
  • Phosphorylation by PRKCA regulates its subcellular location and function in cell motility (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6UVK1

    • 2 DME Specific Peptides for CSPG4 (Q6UVK1)
     LGRSSLS  PLVVAEG 

    CSPG4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001888.2  
    ENSEMBL proteins: 
     ENSP00000312506  
    Reactome Protein details: Q6UVK1
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for CSPG4 (NG2/MCSP)
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    OriGene Protein Over-expression Lysate: CSPG4
    OriGene Custom Protein Services for CSPG4 
    GenScript Custom Purified and Recombinant Proteins Services for CSPG4
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CSPG4

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005622intracellular ----
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane TAS8790396


    CSPG4 for ontologies           About GeneDecksing



    CSPG4 Antibody Products: 
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    Abcam antibodies for CSPG4 
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    ThermoFisher Antibodies for CSPG4

    Assay Products for CSPG4: 
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    Uscn ELISAs and CLIAs for CSPG4

    Protein Domains /
    Families
    for CSPG4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CSPG4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013320 ConA-like_subgrp
     IPR027210 Cspg4
     IPR001791 Laminin_G
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q6UVK1

    ProtoNet protein and cluster: Q6UVK1

    2 Blocks protein families:
    IPB001791 Laminin G
    IPB012679 Laminin G


    UniProtKB/Swiss-Prot: CSPG4_HUMAN, Q6UVK1
    Similarity: Contains 15 CSPG (NG2) repeats
    Similarity: Contains 2 laminin G-like domains


    Function
    for CSPG4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CSPG4_HUMAN, Q6UVK1
    Function: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility
    during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon
    regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that
    substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their
    activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells
    invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting
    angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding
    and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation.
    May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling
    cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades

    Enzyme Numbers (IUBMB): EC 3.6.32 EC 2.7.82

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSPG4
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CSPG4 (see all 12):
    hsa-miR-3065-3p hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-1324 hsa-miR-486-3p hsa-miR-1285 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: CSPG4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSPG4 (see all 7)
    OriGene shRNA RFP: CSPG4
    OriGene siRNA: CSPG4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSPG4

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for CSPG4

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSPG4

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005518collagen binding ----
    GO:0019901protein kinase binding IPI10587647


    CSPG4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Cspg4tm1Wbst for CSPG4
         8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cspg4):
     adipose tissue  cellular  growth/size  homeostasis/metabolism  immune system 
     liver/biliary system  nervous system  no phenotypic analysis 

    CSPG4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CSPG4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/15 pathways (see all 15)
    		MPS IIIC - Sanfilippo syndrome C1.00
    		MPS IIID - Sanfilippo syndrome D1.00
    		MPS I - Hurler syndrome1.00
    		MPS IX - Natowicz syndrome1.00
    		Mucopolysaccharidoses1.00
    		MPS II - Hunter syndrome1.00
    		MPS IV - Morquio syndrome A1.00
    		Glycosaminoglycan metabolism1.00
    2DSPGs are secreted
    		DSPG and CSPG translocate to the lysosome for degradation1.00
    		CSPG is secreted1.00
    		DSPGs are secreted1.00
    		Dermatan sulfate biosynthesis0.70
    		CS is cleaved from its proteoglycan1.00
    		CS/DS degradation0.54
    		DS is cleaved from its proteoglycan1.00
    3Cell adhesion_Cell-matrix glycoconjugates
    		Cell adhesion_Cell-matrix glycoconjugates1.00
    		Cell adhesion Cell-matrix glycoconjugates0.97
    4A tetrasaccharide linker sequence is required for GAG synthesis
    		A tetrasaccharide linker sequence is required for GAG synthesis1.00
    		Chondroitin sulfate/dermatan sulfate metabolism0.54
    5Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CSPG4
        Cell adhesion Cell-matrix glycoconjugates


    2 Cell Signaling Technology (CST) Pathways for CSPG4
        Wnt / Hedgehog / Notch
    Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for CSPG4
        Cell adhesion Cell-matrix glycoconjugates

    5/27        Reactome Pathways for CSPG4 (see all 27)
        Chondroitin sulfate/dermatan sulfate metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    DSPG and CSPG translocate to the lysosome for degradation
    Disease



    CSPG4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSPG4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/71 Interacting proteins for CSPG4 (Q6UVK12, 3 ENSP000003125064) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61904 I2D: score=3 
    BCAR1P569453, ENSP000001623304I2D: score=1 STRING: ENSP00000162330
    ITGA3P260063, ENSP000000077224I2D: score=1 STRING: ENSP00000007722
    ITGB1P055563, ENSP000003640944I2D: score=1 STRING: ENSP00000364094
    GRIP1Q9Y3R03, ENSP000003810984I2D: score=4 STRING: ENSP00000381098
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0001525angiogenesis IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--
    GO:0008283cell proliferation IEA--


    CSPG4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CSPG4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CSPG4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CSPG4

    1 HMDB Compound for CSPG4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Chondroitin sulfateChondritinsulfate (see all 12)9007-28-7--
    3 Novoseek chemical compound relationships for CSPG4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin sulfate 43.3 9 17217338 (2), 11493670 (2), 9099729 (1)
    glycosaminoglycan 38.1 2 17217338 (1), 9099729 (1)
    glutamate 0.0307 2 15504744 (1), 15949494 (1)

    Search CenterWatch for drugs/clinical trials and news about CSPG4 

    Transcripts
    for CSPG4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CSPG4 gene: 
    NM_001897.4  

    Unigene Cluster for CSPG4:

    Chondroitin sulfate proteoglycan 4
    Hs.513044  [show with all ESTs]
    Unigene Representative Sequence: NM_001897
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000308508(uc002baw.3)

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    hsa-miR-3065-3p hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-1324 hsa-miR-486-3p hsa-miR-1285 hsa-miR-4267
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    Inhib. RNA
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    Additional cDNA sequence: 

    AY359468.1 BC033194.1 BC128110.1 X96753.1 

    7 DOTS entries:

    DT.213407  DT.121052811  DT.95165668  DT.100028178  DT.121052879  DT.70104223  DT.95165669 

    24/117 AceView cDNA sequences (see all 117):

    AI452449 BQ680275 BU167327 BQ677440 CA428796 BG015442 BP362998 AI802991 
    AI423029 CA417234 NM_001897 AI276983 AW082096 AI337443 AY359468 BU190456 
    BF062585 CF272486 BM704556 BU191261 BC033194 BI769212 BU169118 BG765234 

    GeneLoc Exon Structure


    Expression
    for CSPG4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSPG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGCCTGGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CSPG4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EndotheliumMicrovesselsPericytesPericytes
    Lateral Plate MesodermSplanchnic MesodermPericytesPericytes
    LimbAutopod Synovial JointInterzone CellsCartilage
    LimbStylopod Synovial JointInterzone CellsCartilage
    LimbZeugopod Synovial JointInterzone CellsCartilage
    LungTracheal CartilageChondrocytesLung
    BoneMandibular CondyleBone
    BoneMandibular FossaBone
    KidneyRenal VesicleKidney
    LungTracheal CartilageLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage

    See CSPG4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSPG4

    SOURCE GeneReport for Unigene cluster: Hs.513044

    UniProtKB/Swiss-Prot: CSPG4_HUMAN, Q6UVK1
    Tissue specificity: Detected only in malignant melanoma cells

        SABiosciences Custom PCR Arrays for CSPG4
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    Orthologs
    for CSPG4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CSPG4 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CSPG41 chondroitin sulfate proteoglycan 4 60.67(n)
    51.29(a)    		   425524  XM_423277.3  XP_423277.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CSPG46
    		 --
    		 48(a)
    		 1 ↔ 1
    		 GL343374.1(70770-88723)
    zebrafish
    (Danio rerio)    		 Actinopterygii cspg41 chondroitin sulfate proteoglycan 4 47.98(n)
    37.48(a)    		   560393  XM_001923422.2  XP_001923457.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta kon1 kon-tiki 41.2(n)
    27.22(a)    		   35104  NM_136037.3  NP_609881.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea C48E7.63   -- 22(a)   I(6247605-6257509)   --


    ENSEMBL Gene Tree for CSPG4 (if available)
    TreeFam Gene Tree for CSPG4 (if available) 

    Paralogs
    for CSPG4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSPG4 gene
    FREM22  FREM12  FREM32  FRAS12  
    1 SIMAP similar gene for CSPG4 using alignment to 3 protein entries:     CSPG4_HUMAN (see all proteins):
    CSPG4P5

    CSPG4 for paralogs           About GeneDecksing


    5/10 Pseudogenes.org Pseudogenes for CSPG4 (see all 10)
    PGOHUM00000262070 PGOHUM00000246902 PGOHUM00000247189 PGOHUM00000262101 PGOHUM00000262105


    Genomic Variants
    for CSPG4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/728 NCBI SNPs in CSPG4 are shown (see all 728)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2003114111,2
    		Cother75982329(+) TTGACA/TCTGAG 2 R S mis10--------
    rs1892555101,2
    		--75966168(+) GCTGCA/GCTCAG 1 -- ds50010--------
    rs1179420071,2
    		--75966295(+) AGAGGG/ATGGTG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs586896451,2
    		C,--75966529(+) TCCTCC/TCCCTC 1 -- ds50012Minor allele frequency- T:0.09WA 120
    rs1810887801,2
    		--75966644(+) GAGGTC/TGAAAC 1 -- ds50010--------
    rs620272381,2
    		C,F,--75966885(+) GGGCCG/AACCCC 1 -- ut317Minor allele frequency- A:0.20NA WA EA 366
    rs1499040741,2
    		--75967039(+) CTCAGC/GGGGGC 1 -- ut310--------
    rs11276501,2
    		C,F,A,--75967053(-) ACTGCG/AGTGCC 1 -- ut31 ese310Minor allele frequency- A:0.37MN NA WA CSA EA 553
    rs11276491,2
    		C,F,A,--75967054(-) CACTGC/G/TGGTGC 2 -- ut31 ese39MN NA WA CSA EA 551
    rs1133580161,2
    		--75967065(+) GCCTCG/AGCCTG 1 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for CSPG4 (75966663 - 76005189 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CSPG4
         1 CNV: 77008

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    Disorders / Diseases
    for CSPG4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CSPG4 for disorders           About GeneDecksing

    OMIM gene information: 601172    OMIM disorders: --

    20/21 diseases for CSPG4 (see all 21):    About MalaCards
    melanoma    spinal cord injury    acral lentiginous melanoma    lichen planus
    oral lichen planus    soft tissue sarcoma    brain injury    acute lymphoblastic leukemia
    multiple sclerosis    lymphoblastic leukemia    angiofibroma    malignant glioma
    angiomyolipoma    encephalomyelitis    meningitis    sarcoma
    leukemia    neurodegeneration    osteoarthritis    glioblastoma

    1 disease from the University of Copenhagen DISEASES database for CSPG4:
    Melanoma

    9 Novoseek disease relationships for CSPG4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 43.7 14 10571405 (4), 9281375 (3), 11919162 (2), 16365873 (1) (see all 6)
    melanoma 36.2 10 17217338 (3), 16365873 (1), 8523067 (1), 20309546 (1) (see all 7)
    demyelinating diseases 33.3 1 15949494 (1)
    minimal residual disease 33.1 1 12886247 (1)
    demyelination 22.2 1 16753227 (1)
    neovascularization 18.6 2 11919162 (1), 15181153 (1)
    multiple sclerosis 13 2 15949494 (1), 16753227 (1)
    tumors 5.34 14 11919162 (4), 10383148 (2), 19618851 (1), 12220645 (1) (see all 6)
    leukemia 0 3 16643437 (1), 12886247 (1)

    Human Genome Epidemiology (HuGE) Navigator: CSPG4 (2 documents)

    Export disorders for CSPG4 gene to outside databases

    Publications
    for CSPG4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSPG4 gene, integrated from 9 sources (see all 100):
    (articles sorted by number of sources associating them with CSPG4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan. (PubMed id 8790396)1, 2, 3 Pluschke G.... Reisfeld R.A. (1996)
    2. NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. (PubMed id 15181153)1, 2, 9 Fukushi J.... Stallcup W.B. (2004)
    3. A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family. (PubMed id 12220645)1, 2, 9 Staub E.... Rosenthal A. (2002)
    4. Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells. (PubMed id 16407841)1, 3 Luo W....Ferrone S. (2006)
    5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    6. Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms. (PubMed id 15210734)1, 2 Yang J.... McCarthy J.B. (2004)
    7. Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. (PubMed id 11278606)1, 2 Iida J....McCarthy J.B. (2001)
    8. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PubMed id 10587647)1, 2 Eisenmann K.M.... Iida J. (1999)
    9. A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion. (PubMed id 9488735)1, 2 Iida J.... McCarthy J.B. (1998)
    10. The expression of NG2 proteoglycan in the human intervertebral disc. (PubMed id 17268261)1, 9 Akeda K....Masuda K. (2007)

    External Searches for CSPG4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CSPG4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1464 HGNC: 2466 AceView: CSPG4 Ensembl:ENSG00000173546 euGenes: HUgn1464
    ECgene: CSPG4 H-InvDB: CSPG4

    Other Databases showing CSPG4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CSPG4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSPG4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSPG4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CSPG4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CSPG4 gene:
    Search GeneIP for patents involving CSPG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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