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CSNK2B Gene

protein-coding   GIFtS: 68
GCID: GC06P031633

Casein Kinase 2, Beta Polypeptide

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Casein Kinase 2, Beta Polypeptide1 2     Casein Kinase II B Subunit Splicing Isoform 3182
Protein G5a2 3     Casein Kinase II B Subunit Splicing Isoform 6602
CK2N2 3     Casein Kinase II B Subunit Splicing Isoform 8062
G5A2 3     Casein Kinase II Beta Subunit2
CK II Beta2 3     Casein Kinase II Subunit Beta2
CK2B2     Chimera CSNK2B-LY6G5B Splicing Isoform 5322
CSK2B2     Chimera CSNK2B-LY6G5B Splicing Isoform 5602
CSNK2B-LY6G5B-5322     phosvitin2
CSNK2B-LY6G5B-5602     Phosvitin3
Alternative Name: G5a, Phosvitin2     

External Ids:    HGNC: 24601   Entrez Gene: 14602   Ensembl: ENSG000002044357   OMIM: 1154415   UniProtKB: P678703   

Export aliases for CSNK2B gene to outside databases

Previous GC identifers: GC06P031698 GC06P031403 GC06P031737 GC06P031741 GC06Pf31767 GC06P031419


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSNK2B Gene:
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic
pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three
subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are
catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum
and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2013)

GeneCards Summary for CSNK2B Gene:
CSNK2B (casein kinase 2, beta polypeptide) is a protein-coding gene. Diseases associated with CSNK2B include theileriasis, and egg allergy. GO annotations related to this gene include identical protein binding and receptor binding. An important paralog of this gene is ENSG00000263020.

UniProtKB/Swiss-Prot: CSK2B_HUMAN, P67870
Function: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic
activity of the alpha subunit

summary for CSNK2B Gene:
Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase
that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2
functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha
and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are
catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the
alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins
implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought
to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the
phosphorylation of Akt.

Gene Wiki entry for CSNK2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSNK2B gene promoter:
         PPAR-gamma1   Pax-5   Hand1   HNF-4alpha2   PPAR-gamma2   E47   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSNK2B promoter sequence
   Search Chromatin IP Primers for CSNK2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSNK2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.33

CSNK2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK2B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031633:  view genomic region     (about GC identifiers)

Start:
31,633,013 bp from pter      End:
31,638,120 bp from pter
Size:
5,108 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167249 2,964,462-2,968,648      Chr6+,NT_167245 2,919,236-2,923,423      Chr6+,NT_167246 2,976,547-2,980,733     
Chr6+,NT_167248 2,927,300-2,931,486      Chr6+,NT_113891.2 3,143,277-3,147,463      Chr6+,NT_167247 3,013,337-3,017,523     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CSK2B_HUMAN, P67870 (See protein sequence)
Recommended Name: Casein kinase II subunit beta  
Size: 215 amino acids; 24942 Da
Subunit: Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit
dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also
component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex
associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts
with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction
between CSNKB and FIBP in binding to FGF1
Sequence caution: Sequence=CAI18393.2; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for CSNK2B (see all 8):
1DS5 (3D)        1JWH (3D)        1QF8 (3D)        3EED (3D)        4DGL (3D)        4MD7 (3D)    
Secondary accessions: B0UXA9 P07312 P13862 Q4VX47

Explore the universe of human proteins at neXtProt for CSNK2B: NX_P67870

Explore proteomics data for CSNK2B at MOPED

Post-translational modifications: 

  • Phosphorylated by alpha subunit1
  • Ubiquitination2 at Lys33, Lys100, Lys134, Lys139, Lys191, Lys208, Lys212
  • Modification sites at PhosphoSitePlus

  • See CSNK2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269314.1  NP_001311.3  

    ENSEMBL proteins: 
     ENSP00000365046   ENSP00000365042   ENSP00000365025   ENSP00000365026  
    Reactome Protein details: P67870

    CSNK2B Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CSNK2B Protein
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    OriGene Protein Over-expression Lysate for CSNK2B
    OriGene MassSpec for CSNK2B
    OriGene Custom Protein Services for CSNK2B
    GenScript Custom Purified and Recombinant Proteins Services for CSNK2B
    Novus Biologicals CSNK2B Proteins
    Novus Biologicals CSNK2B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CSNK2B
    Browse Proteins at Cloud-Clone Corp.

    CSNK2B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CSNK2B
    R&D Systems Antibodies for CSNK2B (Casein Kinase 2 beta)
    OriGene Antibodies for CSNK2B
    OriGene Custom Antibody Services for CSNK2B
    Novus Biologicals CSNK2B Antibodies
    Abcam antibodies for CSNK2B
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CSNK2B
    LSBio Antibodies in human, mouse, rat for CSNK2B

    CSNK2B Assay Products:

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    GenScript Custom Assay Services for CSNK2B
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: casein kinase 2, beta polypeptide subunit
    Selected non-AGC protein kinase activities
    Casein kinase 2 (CK2) family

    3 InterPro protein domains:
     IPR016149 Casein_kin_II_reg-sub_a-hlx
     IPR016150 Casein_kin_II_reg-sub_b-sht
     IPR000704 Casein_kinase_II_reg-sub

    Graphical View of Domain Structure for InterPro Entry P67870

    ProtoNet protein and cluster: P67870

    1 Blocks protein domain: IPB000704 Casein kinase II

    UniProtKB/Swiss-Prot: CSK2B_HUMAN, P67870
    Similarity: Belongs to the casein kinase 2 subunit beta family


    CSNK2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSK2B_HUMAN, P67870
    Function: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic
    activity of the alpha subunit

         Genatlas biochemistry entry for CSNK2B:
    caseine kinase II,beta unit,likely involved in regulation of cell growth

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674contributes to protein serine/threonine kinase activity TAS1856204
    GO:0005102receptor binding IPI19233263
    GO:0005515protein binding IPI10094392
    GO:0008134transcription factor binding IPI19324893
    GO:0016301kinase activity ----
         
    CSNK2B for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CSNK2B:
     G0/1 arrest  Increased G1 DNA content  Increased cell death in HCC-19  Upregulation of Wnt/beta-caten 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Csnk2b):
     behavior/neurological  embryogenesis  growth/size/body  mortality/aging  nervous system 

    CSNK2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Csnk2btm1.2Bb for CSNK2B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CSNK2B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CSNK2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSNK2B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSNK2B

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CSNK2B using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CSNK2B:
    hsa-miR-548am hsa-miR-548d-3p hsa-miR-548x hsa-miR-205* hsa-miR-1260b hsa-miR-32* hsa-miR-1260 hsa-miR-548aa
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CSNK2B
    Predesigned siRNA for gene silencing in human, mouse, rat CSNK2B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CSNK2B

    Clone
    Products:
         
    OriGene clones in human, mouse for CSNK2B (see all 6)
    OriGene ORF clones in mouse, rat for CSNK2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CSNK2B (NM_001320)
    Sino Biological Human cDNA Clone for CSNK2B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSNK2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK2B

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CSNK2B 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular2
    plasma membrane2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA19233263
    GO:0005829cytosol TAS--
    GO:0005886colocalizes with plasma membrane IDA19233263
    GO:0005956protein kinase CK2 complex NAS2666134

    CSNK2B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSNK2B About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    4Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Condensation of Prometaphase Chromosomes0.00
    5Translation Insulin regulation of translation
    Translation Regulation activity of EIF20.47
    Cell adhesion PLAU signaling0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CSNK2B
        Notch Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CSNK2B
        NF-KappaB (p50-p65) Pathway
    Erythropoietin Pathway

    1 Tocris Bioscience Pathway for CSNK2B
        NF-kappaB Pathway

    4 GeneGo (Thomson Reuters) Pathways for CSNK2B
        Cell adhesion PLAU signaling
    DNA damage NHEJ mechanisms of DSBs repair
    Translation Regulation of EIF2 activity
    Regulation of CFTR activity (norm and CF)

    3 BioSystems Pathways for CSNK2B
        Wnt Signaling Pathway NetPath
    TNF-alpha/NF-kB Signaling Pathway
    ALK1 signaling events


    3 Reactome Pathways for CSNK2B
        Signal transduction by L1
    WNT mediated activation of DVL
    Condensation of Prometaphase Chromosomes


    Selected Kegg Pathways  (Kegg details for CSNK2B) (see all 8):
        Ribosome biogenesis in eukaryotes
    NF-kappa B signaling pathway
    Wnt signaling pathway
    Adherens junction
    Tight junction


    CSNK2B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSNK2B: 
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CSNK2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSNK2B (P678701, 2, 3 ENSP000003650254) via UniProtKB, MINT, STRING, and/or I2D (see all 278)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT1Q96EB61, 2, 3EBI-348169,EBI-1802965 MINT-8206425 MINT-8206396 MINT-8206373 MINT-8206385 MINT-8206442 MINT-8206407 I2D: score=1 
    CSNK2A2P197841, 2, 3, ENSP000002625064EBI-348169,EBI-347451 MINT-62609 MINT-62783 MINT-62707 I2D: score=6 STRING: ENSP00000262506
    PACS1Q6VY071, 2, 3EBI-348169,EBI-2555014 MINT-3372585 MINT-3372614 MINT-3372643 I2D: score=1 
    C6orf136Q5SQH82, 3MINT-8253099 I2D: score=2 
    ENSG00000206487Q5SQH82, 3MINT-8253099 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006468protein phosphorylation TAS1856204
    GO:0007165signal transduction TAS2513884
    GO:0007411axon guidance TAS--
    GO:0008285negative regulation of cell proliferation TAS19324893

    CSNK2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CSNK2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TMCBDual-kinase inhibitor; inhibits CK2 and ERK8[905105-89-7]
    TBBSelective cell-permeable CK2 inhibitor[17374-26-4]
    TTP 22 High affinity, selective CK2 inhibitor [329907-28-0]
    Ellagic acidSelective inhibitor of CK2. Also inhibits glutathione S-transferase[476-66-4]

    2 HMDB Compounds for CSNK2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected Novoseek inferred chemical compound relationships for CSNK2B gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipovitellin 82.6 3 11513694 (1), 8502607 (1), 9037702 (1)
    kemptide 65.1 3 8527311 (3)
    phosphoserine 62.9 2 1791469 (1), 1965857 (1)
    threonine 53.9 3 1295885 (2), 7864634 (1)
    serine 48.9 6 1791469 (2), 1590772 (1), 1295885 (1), 12551973 (1) (see all 5)
    hydroxyapatite 44.7 41 2170349 (6), 1659832 (4), 16851965 (4), 16055080 (2) (see all 5)
    gtp 40 3 7735321 (1), 11853545 (1), 1295885 (1)
    atp 35.4 5 7735321 (1), 11853545 (1), 1295885 (1), 8527311 (1) (see all 5)
    nacl 35.3 1 7735321 (1)
    protamine 31.1 2 1311309 (1), 7864634 (1)



    CSNK2B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CSNK2B gene (2 alternative transcripts): 
    NM_001282385.1  NM_001320.6  

    Unigene Cluster for CSNK2B:

    Casein kinase 2, beta polypeptide
    Hs.73527  [show with all ESTs]
    Unigene Representative Sequence: BM912855
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375885 ENST00000375882(uc003nvr.1) ENST00000468255(uc010jta.1 uc021yuv.1)
    ENST00000465481 ENST00000481269 ENST00000475875(uc010jsz.1) ENST00000375865
    ENST00000375866
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate CSNK2B:
    hsa-miR-548am hsa-miR-548d-3p hsa-miR-548x hsa-miR-205* hsa-miR-1260b hsa-miR-32* hsa-miR-1260 hsa-miR-548aa
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector: CSNK2B (NM_001320)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSNK2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK2B
    Primer
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    OriGene qPCR primer pairs and template standards for CSNK2B
    OriGene qSTAR qPCR primer pairs in human, mouse for CSNK2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSNK2B
      QuantiTect SYBR Green Assays in human, mouse, rat CSNK2B
      QuantiFast Probe-based Assays in human, mouse, rat CSNK2B

    Additional mRNA sequence: 

    AK300671.1 AK308742.1 AK310551.1 AK310954.1 AK311860.1 AY113186.1 BC112017.1 BC112019.1 
    CR541699.1 X16312.1 X16937.1 

    23 DOTS entries:

    DT.100803539  DT.40250887  DT.100660707  DT.91854909  DT.95365897  DT.100753713  DT.91855355  DT.91855284 
    DT.95175640  DT.100749818  DT.121325864  DT.121325866  DT.95142818  DT.121325878  DT.100044302  DT.100863724 
    DT.121325850  DT.121325906  DT.95288045  DT.95365932  DT.95365998  DT.100732064  DT.95365933 

    1 AceView cDNA sequence:

    AJ711351 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSNK2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCATCCCG
    CSNK2B Expression
    About this image

    CSNK2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSNK2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73527
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSNK2B: 
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSNK2B gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csnk2b1 , 5 casein kinase 2, beta polypeptide1, 5 93.8(n)1
    100(a)1
      17 (18.59 cM)5
    130011  NM_009975.21  NP_034105.11 
     351161965 
    lizard
    (Anolis carolinensis)
    Reptilia CSNK2B6
    casein kinase 2, beta polypeptide
    92(a)
    1 ↔ 1
    2(193368686-193374412)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.11522 X.laevis mRNA for beta subunit of casein kinase II 80.95(n)    X62376.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ck2b2 casein kinase 2 beta 85.32(n)   30428  NM_131187.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CkII&bgr;3
    CkIIbeta1
    protein amino acid phosphorylation
    protein kinase3
    Casein kinase II beta subunit1
    89(a)
    (best of 4)3
    74.88(n)1
    88.37(a)1
      10E33
    321321  NM_206692.31  NP_996415.11 
    worm
    (Caenorhabditis elegans)
    Secernentea kin-101 , 3 KIN-10 casein kinase3
    kin-101
    81(a)
    (best of 2)3
    69.83(n)1
    81(a)1
      I(8297260-8298873)3
    1726101  NM_059853.31  NP_492254.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CKB2(YOR039W)4
    CKB21
    Beta' regulatory subunit of casein kinase 2 (CK2), more4
    CKB21
    52.2(n)1
    47.8(a)1
      15(405768-406544)4
    8542041, 4  NP_014682.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CKB41 CKB4 56.42(n)
    57.81(a)
      819076  NM_130032.2  NP_181996.1 
    rice
    (Oryza sativa)
    Liliopsida Os.112232 Oryza sativa (japonica cultivar-group) putative casein more 71.23(n)    AK111555.1 


    ENSEMBL Gene Tree for CSNK2B (if available)
    TreeFam Gene Tree for CSNK2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSNK2B gene
    ENSG000002630202  
    7 SIMAP similar genes for CSNK2B using alignment to 7 protein entries:     CSK2B_HUMAN (see all proteins):
    CSNK2B-LY6G5B-182    CSNK2B-LY6G5B-696    CSNK2B-LY6G5B--991    CSNK2B-LY6G5B-1181    CSNK2B-LY6G5B-560    CSNK2B-LY6G5B-1072
    CSNK2B-LY6G5B-562

    CSNK2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    7 SNPs for CSNK2B    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1496426951,2
    C--31636083(+) AGTTGA/GGAGGG 1 -- int10--------
    rs1443654181,2
    C--31636141(+) TCTTCA/GTTTGA 1 -- int10--------
    rs1998724041,2
    ----31636368(+) GCAGCC/TGAGAT 2 A syn11Minor allele frequency- T:0.00EU 1323
    rs3750599361,2
    ----31636609(+) GTTTTC/TAGGGA 1 -- int10--------
    rs3756847471,2
    ----31636514(+) AGCCCC/TTTTAA 1 -- int10--------
    rs3721258071,2
    ----31636397(+) CGCCCA/GCTACA 2 H R mis10--------
    rs3720305501,2
    ----31636519(+) TGTTTA/GAGGAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for CSNK2B (31633013 - 31638120 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CSNK2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830627CNV Loss17160897
    nsv884418CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSNK2B
    DNA2.0 Custom Variant and Variant Library Synthesis for CSNK2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 115441    OMIM disorders: --

    Selected diseases for CSNK2B (see all 27):    
    About MalaCards
    theileriasis    egg allergy    orchitis    vaccinia
    laryngeal squamous cell carcinoma    xeroderma pigmentosum    gout    teratocarcinoma
    measles    laryngitis    herpes simplex    polycystic kidney disease
    endometrial carcinoma    hiv-1    systemic lupus erythematosus    ataxia
    chronic lymphocytic leukemia    lupus erythematosus    parkinson's disease    kidney disease


    CSNK2B for disorders           About GeneDecksing

    Genetic Association Database (GAD): CSNK2B
    Human Genome Epidemiology (HuGE) Navigator: CSNK2B (6 documents)

    Export disorders for CSNK2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSNK2B gene, integrated from 10 sources (see all 303):
    (articles sorted by number of sources associating them with CSNK2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the gene encoding human casein kinase II subunit beta. (PubMed id 1856204)1, 2, 9 Voss A.... Pyerin W. (J. Biol. Chem. 1991)
    2. Assignment of the human casein kinase II beta-subunit gene to 6p12----p21. (PubMed id 2276748)1, 3, 9 Yang-Feng T.L....Canaani D. (Genomics 1990)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    5. Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis. (PubMed id 18835879)1, 4 Harney S.M....Brown M.A. (Rheumatology (Oxford) 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (Genome Res. 2003)
    9. p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. (PubMed id 12393879)1, 2 Keller D.M. and Lu H. (J. Biol. Chem. 2002)
    10. Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line. (PubMed id 12102635)1, 2 Singh L.S. and Kalafatis M. (Biochemistry 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1460 HGNC: 2460 AceView: CSNK2B Ensembl:ENSG00000204435 euGenes: HUgn1460
    ECgene: CSNK2B Kegg: 1460 H-InvDB: CSNK2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CSNK2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSNK2B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSNK2B gene:
    Search GeneIP for patents involving CSNK2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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