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Aliases for CSNK2B Gene

Aliases for CSNK2B Gene

  • Casein Kinase 2, Beta Polypeptide 2 3
  • Protein G5a 3 4
  • CK II Beta 3 4
  • Phosvitin 3 4
  • CK2N 3 4
  • G5A 3 4
  • Casein Kinase II B Subunit Splicing Isoform 132 3
  • Casein Kinase II B Subunit Splicing Isoform 247 3
  • Casein Kinase II B Subunit Splicing Isoform 318 3
  • Casein Kinase II B Subunit Splicing Isoform 660 3
  • Casein Kinase II B Subunit Splicing Isoform 806 3
  • Chimera CSNK2B-LY6G5B Splicing Isoform 1072 3
  • Chimera CSNK2B-LY6G5B Splicing Isoform 1103 3
  • Chimera CSNK2B-LY6G5B Splicing Isoform 532 3
  • Chimera CSNK2B-LY6G5B Splicing Isoform 560 3
  • Chimera CSNK2B-LY6G5B Splicing Isoform 562 3
  • Alternative Name: G5a, Phosvitin 3
  • Casein Kinase II Beta Subunit 3
  • CSNK2B-LY6G5B-1072 3
  • CSNK2B-LY6G5B-1103 3
  • CSNK2B-LY6G5B-532 3
  • CSNK2B-LY6G5B-560 3
  • CSNK2B-LY6G5B-562 3
  • CSK2B 3
  • CK2B 3

External Ids for CSNK2B Gene

Previous GeneCards Identifiers for CSNK2B Gene

  • GC06P031698
  • GC06P031403
  • GC06P031737
  • GC06P031741
  • GC06Pf31767
  • GC06P031633
  • GC06P031419
  • GC06P031666

Summaries for CSNK2B Gene

Entrez Gene Summary for CSNK2B Gene

  • This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for CSNK2B Gene

CSNK2B (Casein Kinase 2, Beta Polypeptide) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Developmental Biology. GO annotations related to this gene include identical protein binding and receptor binding. An important paralog of this gene is ENSG00000263020.

UniProtKB/Swiss-Prot for CSNK2B Gene

  • Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.

Tocris Summary for CSNK2B Gene

  • Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase thought to have a regulatory function in cell proliferation, differentiation and apoptosis. CK2 functions as a tetrameric complex with 2 regulatory and 2 catalytic subunits.

Gene Wiki entry for CSNK2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK2B Gene

Genomics for CSNK2B Gene

Regulatory Elements for CSNK2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CSNK2B Gene

Chromosome:
6
Start:
31,665,236 bp from pter
End:
31,670,343 bp from pter
Size:
5,108 bases
Orientation:
Plus strand

Genomic View for CSNK2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSNK2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for CSNK2B Gene

  • Protein details for CSNK2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P67870-CSK2B_HUMAN
    Recommended name:
    Casein kinase II subunit beta
    Protein Accession:
    P67870
    Secondary Accessions:
    • B0UXA9
    • P07312
    • P13862
    • Q4VX47

    Protein attributes for CSNK2B Gene

    Size:
    215 amino acids
    Molecular mass:
    24942 Da
    Quaternary structure:
    • Tetramer composed of an alpha subunit, an alpha subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.
    SequenceCaution:
    • Sequence=CAI18393.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CSNK2B Gene

neXtProt entry for CSNK2B Gene

Proteomics data for CSNK2B Gene at MOPED

Post-translational modifications for CSNK2B Gene

  • Phosphorylated by alpha subunit.
  • Ubiquitination at Lys 33, Lys 100, Lys 134, Lys 139, Lys 191, and Lys 212
  • Modification sites at PhosphoSitePlus

Other Protein References for CSNK2B Gene

Antibody Products

  • R&D Systems Antibodies for CSNK2B (Casein Kinase 2 beta)

No data available for DME Specific Peptides for CSNK2B Gene

Domains & Families for CSNK2B Gene

Graphical View of Domain Structure for InterPro Entry

P67870

UniProtKB/Swiss-Prot:

CSK2B_HUMAN :
  • Belongs to the casein kinase 2 subunit beta family.
Family:
  • Belongs to the casein kinase 2 subunit beta family.
genes like me logo Genes that share domains with CSNK2B: view

Function for CSNK2B Gene

Molecular function for CSNK2B Gene

GENATLAS Biochemistry:
caseine kinase II,beta unit,likely involved in regulation of cell growth
UniProtKB/Swiss-Prot Function:
Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.

Gene Ontology (GO) - Molecular Function for CSNK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 25519132
GO:0004674 contributes_to protein serine/threonine kinase activity TAS 1856204
GO:0005102 receptor binding IPI 19233263
GO:0005515 protein binding IPI 10094392
GO:0008134 transcription factor binding IPI 19324893
genes like me logo Genes that share ontologies with CSNK2B: view
genes like me logo Genes that share phenotypes with CSNK2B: view

Animal Models for CSNK2B Gene

MGI Knock Outs for CSNK2B:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSNK2B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CSNK2B Gene

Localization for CSNK2B Gene

Gene Ontology (GO) - Cellular Components for CSNK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21282530
GO:0005737 cytoplasm IDA 19233263
GO:0005829 cytosol TAS --
GO:0005886 colocalizes_with plasma membrane IDA 19233263
GO:0005956 protein kinase CK2 complex NAS 2666134
genes like me logo Genes that share ontologies with CSNK2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CSNK2B Gene

Pathways & Interactions for CSNK2B Gene

genes like me logo Genes that share pathways with CSNK2B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for CSNK2B Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CSNK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006468 protein phosphorylation TAS 1856204
GO:0007165 signal transduction TAS 2513884
GO:0007411 axon guidance TAS --
GO:0008285 negative regulation of cell proliferation TAS 19324893
genes like me logo Genes that share ontologies with CSNK2B: view

Drugs & Compounds for CSNK2B Gene

(15) Drugs for CSNK2B Gene - From: NovoSeek, HMDB, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Heparin Approved, Investigational Pharma Antagonist 672,226
Iron Approved Pharma 957
Zinc Approved Pharma 1404
Vitamin C Approved Nutra 398,398

(13) Additional Compounds for CSNK2B Gene - From: HMDB, NovoSeek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
TBB
17374-26-4
TMCB
905105-89-7
gtp
Partial agonist, Agonist
H2O2
genes like me logo Genes that share compounds with CSNK2B: view

Transcripts for CSNK2B Gene

mRNA/cDNA for CSNK2B Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSNK2B Gene

Casein kinase 2, beta polypeptide:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSNK2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK2B Gene

No ASD Table

Relevant External Links for CSNK2B Gene

GeneLoc Exon Structure for
CSNK2B
ECgene alternative splicing isoforms for
CSNK2B

Expression for CSNK2B Gene

mRNA expression in normal human tissues for CSNK2B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSNK2B Gene



SOURCE GeneReport for Unigene cluster for CSNK2B Gene Hs.73527

genes like me logo Genes that share expression patterns with CSNK2B: view

Protein tissue co-expression partners for CSNK2B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSNK2B Gene

Orthologs for CSNK2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSNK2B 35
  • 95.04 (n)
  • 100 (a)
CSNK2B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSNK2B 35
  • 95.81 (n)
  • 100 (a)
CSNK2B 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csnk2b 35
  • 93.8 (n)
  • 100 (a)
Csnk2b 16
Csnk2b 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSNK2B 35
  • 99.84 (n)
  • 100 (a)
CSNK2B 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csnk2b 35
  • 94.57 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia CSNK2B 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CSNK2B 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk2b 35
  • 81.86 (n)
  • 99.53 (a)
Str.7978 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1152 35
zebrafish
(Danio rerio)
Actinopterygii ck2b 35
  • 85.12 (n)
  • 99.07 (a)
ck2b 36
  • 99 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.293 35
fruit fly
(Drosophila melanogaster)
Insecta CkIIbgr 37
  • 89 (a)
CkIIbgr2 37
  • 65 (a)
Ssl 37
  • 48 (a)
Ste12DOR 37
  • 42 (a)
CkIIbeta 35
  • 74.88 (n)
  • 88.37 (a)
CkIIbeta 36
  • 80 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-10 37
  • 81 (a)
T01G9.6a 37
  • 81 (a)
kin-10 35
  • 69.83 (n)
  • 81 (a)
kin-10 36
  • 70 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR087C 35
  • 55.72 (n)
  • 46.38 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21869g 35
  • 50.33 (n)
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKB2 35
  • 52.2 (n)
  • 47.8 (a)
CKB2 36
  • 38 (a)
OneToMany
CKB2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CKB4 35
  • 56.42 (n)
  • 57.81 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1389 35
rice
(Oryza sativa)
Liliopsida Os.11223 35
Os07g0495100 35
  • 56.6 (n)
  • 59.37 (a)
corn
(Zea mays)
Liliopsida Zm.808 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7419 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02754 35
  • 57.59 (n)
  • 52.88 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ckb1 35
  • 56.87 (n)
  • 61.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4732 36
  • 88 (a)
OneToMany
Species with no ortholog for CSNK2B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK2B Gene

ENSEMBL:
Gene Tree for CSNK2B (if available)
TreeFam:
Gene Tree for CSNK2B (if available)

Paralogs for CSNK2B Gene

Paralogs for CSNK2B Gene

genes like me logo Genes that share paralogs with CSNK2B: view

Variants for CSNK2B Gene

Structural Variations from Database of Genomic Variants (DGV) for CSNK2B Gene

Variant ID Type Subtype PubMed ID
nsv830627 CNV Loss 17160897
nsv884418 CNV Gain 21882294

Variation tolerance for CSNK2B Gene

Residual Variation Intolerance Score: 49.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK2B Gene

HapMap Linkage Disequilibrium report
CSNK2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CSNK2B Gene

Disorders for CSNK2B Gene

Relevant External Links for CSNK2B

Genetic Association Database (GAD)
CSNK2B
Human Genome Epidemiology (HuGE) Navigator
CSNK2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK2B
genes like me logo Genes that share disorders with CSNK2B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK2B Gene

Publications for CSNK2B Gene

  1. Assignment of the human casein kinase II beta-subunit gene to 6p12----p21. (PMID: 2276748) Yang-Feng T.L. … Canaani D. (Genomics 1990) 2 23 67
  2. Phosvitin-calcium aggregation and organization at the air-water interface. (PMID: 18068959) Belhomme C. … Anton M. (Colloids Surf B Biointerfaces 2008) 23 67
  3. CK2alpha/CK1alpha chimeras are sensitive to regulation by the CK2beta subunit. (PMID: 18622690) Jedlicki A. … Allende J.E. (Mol. Cell. Biochem. 2008) 23 67
  4. Rapid and sensitive determination of phosphoamino acids in phosvitin by N-hydroxysuccinimidyl fluorescein-O-acetate derivatization and capillary zone electrophoresis with laser-induced fluorescence detection. (PMID: 18648781) Deng Y.H. … Wang H. (Anal Bioanal Chem 2008) 23 67
  5. Immobilized metal affinity electrophoresis: a novel method of capturing phosphoproteins by electrophoresis. (PMID: 19137092) Lee B.S. … Gupta S. (J Biomol Tech 2008) 23 67

Products for CSNK2B Gene

Sources for CSNK2B Gene

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