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Aliases for CSNK2B Gene

Aliases for CSNK2B Gene

  • Casein Kinase 2 Beta 2 3 5
  • Casein Kinase 2, Beta Polypeptide 2 3
  • Protein G5a 3 4
  • CK II Beta 3 4
  • Phosvitin 3 4
  • CK2N 3 4
  • G5A 3 4
  • Casein Kinase II B Subunit Splicing Isoform 132 3
  • Casein Kinase II B Subunit Splicing Isoform 247 3
  • Casein Kinase II B Subunit Splicing Isoform 318 3
  • Casein Kinase II B Subunit Splicing Isoform 660 3
  • Casein Kinase II B Subunit Splicing Isoform 806 3
  • Chimera CSNK2B-LY6G5B Splicing Isoform 1072 3
  • Chimera CSNK2B-LY6G5B Splicing Isoform 1103 3
  • Chimera CSNK2B-LY6G5B Splicing Isoform 532 3
  • Chimera CSNK2B-LY6G5B Splicing Isoform 560 3
  • Chimera CSNK2B-LY6G5B Splicing Isoform 562 3
  • Alternative Name: G5a, Phosvitin 3
  • Casein Kinase II Beta Subunit 3
  • Casein Kinase II Subunit Beta 3
  • CSNK2B-LY6G5B-1072 3
  • CSNK2B-LY6G5B-1103 3
  • CSNK2B-LY6G5B-532 3
  • CSNK2B-LY6G5B-560 3
  • CSNK2B-LY6G5B-562 3
  • CSK2B 3
  • CK2B 3

External Ids for CSNK2B Gene

Previous GeneCards Identifiers for CSNK2B Gene

  • GC06P031698
  • GC06P031403
  • GC06P031737
  • GC06P031741
  • GC06Pf31767
  • GC06P031633
  • GC06P031419
  • GC06P031666
  • GC06P031711
  • GC06P031770
  • GC06P031779
  • GC06P031789

Summaries for CSNK2B Gene

Entrez Gene Summary for CSNK2B Gene

  • This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for CSNK2B Gene

CSNK2B (Casein Kinase 2 Beta) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and DNA damage_NHEJ mechanisms of DSBs repair. GO annotations related to this gene include identical protein binding and receptor binding.

UniProtKB/Swiss-Prot for CSNK2B Gene

  • Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.

Tocris Summary for CSNK2B Gene

  • Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase thought to have a regulatory function in cell proliferation, differentiation and apoptosis. CK2 functions as a tetrameric complex with 2 regulatory and 2 catalytic subunits.

Gene Wiki entry for CSNK2B Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK2B Gene

Genomics for CSNK2B Gene

Regulatory Elements for CSNK2B Gene

Enhancers for CSNK2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G031567 2.1 FANTOM5 Ensembl ENCODE dbSUPER 34.9 -86.8 -86818 22.2 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 DDX39B TNF LY6G5B LSM2 DHX16 ATF6B TCF19 PPP1R10 VARS CSNK2B
GH06G031829 1.4 ENCODE dbSUPER 23.5 +168.9 168921 9.1 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D LSM2 LY6G5B ATF6B DDX39B SKIV2L VARS LY6G6C GTF2H4 CSNK2B BAG6
GH06G030746 2.1 FANTOM5 Ensembl ENCODE dbSUPER 14.1 -913.8 -913809 9.5 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 IER3 DHX16 LY6G5B GTF2H4 DDX39B PPP1R10 PAIP1P1 ABCF1 HLA-K VARS2
GH06G030777 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -882.9 -882871 10.1 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF263 SP3 NFYC IER3 PPP1R10 PAIP1P1 VARS2 LY6G5B GTF2H4 DHX16 NFKBIL1 DDR1 ETF1P1
GH06G031817 1.8 FANTOM5 ENCODE dbSUPER 14.2 +157.5 157544 10.7 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ATF6B SKIV2L LSM2 DDX39B VARS LY6G5B BAG6 STK19B C4A CSNK2B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CSNK2B on UCSC Golden Path with GeneCards custom track

Promoters for CSNK2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195577 464 2201 MLX CREB3L1 ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC

Genomic Location for CSNK2B Gene

Chromosome:
6
Start:
31,665,236 bp from pter
End:
31,670,343 bp from pter
Size:
5,108 bases
Orientation:
Plus strand

Genomic View for CSNK2B Gene

Genes around CSNK2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for CSNK2B Gene

  • Protein details for CSNK2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P67870-CSK2B_HUMAN
    Recommended name:
    Casein kinase II subunit beta
    Protein Accession:
    P67870
    Secondary Accessions:
    • B0UXA9
    • P07312
    • P13862
    • Q4VX47

    Protein attributes for CSNK2B Gene

    Size:
    215 amino acids
    Molecular mass:
    24942 Da
    Quaternary structure:
    • Tetramer composed of an alpha subunit, an alpha subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.
    SequenceCaution:
    • Sequence=CAI18393.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CSNK2B Gene

neXtProt entry for CSNK2B Gene

Post-translational modifications for CSNK2B Gene

  • Phosphorylated by alpha subunit.
  • Ubiquitination at isoforms=33, Lys100, Lys134, Lys139, isoforms=191, and Lys212
  • Modification sites at PhosphoSitePlus

Other Protein References for CSNK2B Gene

No data available for DME Specific Peptides for CSNK2B Gene

Domains & Families for CSNK2B Gene

Graphical View of Domain Structure for InterPro Entry

P67870

UniProtKB/Swiss-Prot:

CSK2B_HUMAN :
  • Belongs to the casein kinase 2 subunit beta family.
Family:
  • Belongs to the casein kinase 2 subunit beta family.
genes like me logo Genes that share domains with CSNK2B: view

Function for CSNK2B Gene

Molecular function for CSNK2B Gene

GENATLAS Biochemistry:
caseine kinase II,beta unit,likely involved in regulation of cell growth
UniProtKB/Swiss-Prot Function:
Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.

Gene Ontology (GO) - Molecular Function for CSNK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 25519132
GO:0004674 contributes_to protein serine/threonine kinase activity TAS 1856204
GO:0005102 receptor binding IPI 19233263
GO:0005515 protein binding IPI 10094392
GO:0008134 transcription factor binding IPI 19324893
genes like me logo Genes that share ontologies with CSNK2B: view
genes like me logo Genes that share phenotypes with CSNK2B: view

Animal Models for CSNK2B Gene

MGI Knock Outs for CSNK2B:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CSNK2B Gene

Localization for CSNK2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK2B gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for CSNK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 21282530
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 19233263
genes like me logo Genes that share ontologies with CSNK2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CSNK2B Gene

Pathways & Interactions for CSNK2B Gene

genes like me logo Genes that share pathways with CSNK2B: view

Pathways by source for CSNK2B Gene

SIGNOR curated interactions for CSNK2B Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CSNK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0006468 protein phosphorylation IEA --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0007165 signal transduction TAS 2513884
GO:0008285 negative regulation of cell proliferation TAS 19324893
genes like me logo Genes that share ontologies with CSNK2B: view

Drugs & Compounds for CSNK2B Gene

(17) Drugs for CSNK2B Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Ellagic acid Investigational Pharma Casein kinase 2 (CK2) inhibitor, Selective inhibitor of CK2. Also inhibits glutathione S-transferase 0
TTP 22 Pharma CK2 inhibitor, High affinity, selective CK2 inhibitor 0
CX-4945 (Silmitasertib) Pharma CK2 inhibitor 0
TBB Pharma Casein kinase-2 (CK2) inhibitor, Selective cell-permeable CK2 inhibitor 0

(12) Additional Compounds for CSNK2B Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
TBCA
934358-00-6

(5) Tocris Compounds for CSNK2B Gene

Compound Action Cas Number
Ellagic acid Selective inhibitor of CK2. Also inhibits glutathione S-transferase 476-66-4
TBB Selective cell-permeable CK2 inhibitor 17374-26-4
TBCA Selective CK2 inhibitor 934358-00-6
TMCB Dual-kinase inhibitor; inhibits CK2 and ERK8 905105-89-7
TTP 22 High affinity, selective CK2 inhibitor 329907-28-0

(3) ApexBio Compounds for CSNK2B Gene

Compound Action Cas Number
CX-4945 (Silmitasertib) CK2 inhibitor 1009820-21-6
Ellagic acid Casein kinase 2 (CK2) inhibitor 476-66-4
TTP 22 CK2 inhibitor 329907-28-0
genes like me logo Genes that share compounds with CSNK2B: view

Drug Products

Transcripts for CSNK2B Gene

mRNA/cDNA for CSNK2B Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSNK2B Gene

Casein kinase 2, beta polypeptide:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK2B Gene

No ASD Table

Relevant External Links for CSNK2B Gene

GeneLoc Exon Structure for
CSNK2B
ECgene alternative splicing isoforms for
CSNK2B

Expression for CSNK2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSNK2B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSNK2B Gene



Protein tissue co-expression partners for CSNK2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CSNK2B Gene:

CSNK2B

SOURCE GeneReport for Unigene cluster for CSNK2B Gene:

Hs.73527

Evidence on tissue expression from TISSUES for CSNK2B Gene

  • Liver(4.6)
  • Nervous system(4.4)
  • Blood(2.6)
  • Muscle(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with CSNK2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK2B Gene

Orthologs for CSNK2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK2B 34 35
  • 99.84 (n)
oppossum
(Monodelphis domestica)
Mammalia CSNK2B 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSNK2B 34 35
  • 95.81 (n)
cow
(Bos Taurus)
Mammalia CSNK2B 34 35
  • 95.04 (n)
rat
(Rattus norvegicus)
Mammalia Csnk2b 34
  • 94.57 (n)
mouse
(Mus musculus)
Mammalia Csnk2b 34 16 35
  • 93.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CSNK2B 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk2b 34
  • 81.86 (n)
Str.7978 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1152 34
zebrafish
(Danio rerio)
Actinopterygii ck2b 34 35
  • 85.12 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.293 34
fruit fly
(Drosophila melanogaster)
Insecta CkIIbgr 36
  • 89 (a)
CkIIbeta 34 35
  • 74.88 (n)
CkIIbgr2 36
  • 65 (a)
Ssl 36
  • 48 (a)
Ste12DOR 36
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea T01G9.6a 36
  • 81 (a)
kin-10 36 34 35
  • 69.83 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR087C 34
  • 55.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKB2 34 35 37
  • 52.2 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21869g 34
  • 50.33 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons CKB4 34
  • 56.42 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1389 34
rice
(Oryza sativa)
Liliopsida Os07g0495100 34
  • 56.6 (n)
Os.11223 34
corn
(Zea mays)
Liliopsida Zm.808 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4732 35
  • 88 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU02754 34
  • 57.59 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ckb1 34
  • 56.87 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7419 34
Species where no ortholog for CSNK2B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK2B Gene

ENSEMBL:
Gene Tree for CSNK2B (if available)
TreeFam:
Gene Tree for CSNK2B (if available)

Paralogs for CSNK2B Gene

No data available for Paralogs for CSNK2B Gene

Variants for CSNK2B Gene

Sequence variations from dbSNP and Humsavar for CSNK2B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000010643 -- 31,669,921(+) CGATT(C/T)GCTGA upstream-variant-2KB, reference, missense
rs1000552968 -- 31,665,533(+) CCCAC(C/T)CCACC intron-variant, upstream-variant-2KB
rs1000896848 -- 31,665,677(+) CCCAG(A/C)GGATT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1002874034 -- 31,670,103(+) GAAGG(A/G)AAGGT downstream-variant-500B, upstream-variant-2KB
rs1003888690 -- 31,666,216(+) GAGTC(C/T)GAAGT intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CSNK2B Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv1161370 CNV deletion 26073780
nsv830627 CNV loss 17160897

Variation tolerance for CSNK2B Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK2B Gene

Disorders for CSNK2B Gene

Relevant External Links for CSNK2B

Genetic Association Database (GAD)
CSNK2B
Human Genome Epidemiology (HuGE) Navigator
CSNK2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK2B

No disorders were found for CSNK2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK2B Gene

Publications for CSNK2B Gene

  1. Structure of the gene encoding human casein kinase II subunit beta. (PMID: 1856204) Voss A. … Pyerin W. (J. Biol. Chem. 1991) 3 4 22 64
  2. Assignment of the human casein kinase II beta-subunit gene to 6p12----p21. (PMID: 2276748) Yang-Feng T.L. … Canaani D. (Genomics 1990) 2 3 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  5. Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis. (PMID: 18835879) Harney S.M. … Brown M.A. (Rheumatology (Oxford) 2008) 3 46 64

Products for CSNK2B Gene

Sources for CSNK2B Gene