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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CSNK2B Gene

protein-coding GIFtS: 65
GCID: GC06P031633

casein kinase 2, beta polypeptide

Explore 29 diseases affiliated with
CSNK2B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Casein Kinase 2, Beta Polypeptide¹ ²		CSK2B²
Protein G5a² ³		Alternative Name: G5a, Phosvitin²
CK2N² ³		Casein Kinase II Beta Subunit²
G5A² ³		Casein Kinase II Subunit Beta²
CK II Beta² ³		Phosvitin³
CK2B²		Phosvitin³

External Ids:	HGNC: 2460¹	Entrez Gene: 1460²	Ensembl: ENSG00000204435⁷	OMIM: 115441⁵	UniProtKB: P67870³

Export aliases for CSNK2B gene to outside databases

Previous GC identifers: GC06P031698 GC06P031403 GC06P031737 GC06P031741 GC06Pf31767 GC06P031419

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSNK2B:

This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways,

signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha,

alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the

beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CSK2B_HUMAN, P67870

Function: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic

activity of the alpha subunit

summary for CSNK2B:

Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase

that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2

functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha

and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are

catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the

alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins

implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought

to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the

phosphorylation of Akt.

Gene Wiki entry for CSNK2B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1

NT_167249.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CSNK2B gene promoter:
PPAR-gamma1 Pax-5 Hand1 HNF-4alpha2 PPAR-gamma2 E47 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CSNK2B promoter sequence

Search SABiosciences Chromatin IP Primers for CSNK2B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK2B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.33

CSNK2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK2B gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P031633: view genomic region (about GC identifiers)

Start:	31,633,013 bp from pter	End:	31,638,120 bp from pter
Size:	5,108 bases	Orientation:	plus strand

6 alternative locations:

Chr6+,ALT_REF_LOCI_4 31,596,206-31,600,392	Chr6+,ALT_REF_LOCI_6 31,623,259-31,663,670	Chr6+,ALT_REF_LOCI_3 31,615,195-31,631,064
Chr6+,ALT_REF_LOCI_2 31,620,429-31,664,447	Chr6+,ALT_REF_LOCI_5 31,624,760-31,628,946	Chr6+,ALT_REF_LOCI_7 31,553,927-31,558,113

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CSK2B_HUMAN, P67870 (See protein sequence)

Recommended Name: Casein kinase II subunit beta

Size: 215 amino acids; 24942 Da

Subunit: Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization

is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a

CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV

irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is

increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to

FGF1

Sequence caution: Sequence=CAI18393.2; Type=Erroneous initiation;

5 PDB 3D structures from and Proteopedia for CSNK2B:

1DS5 (3D)

1JWH (3D)

1QF8 (3D)

3EED (3D)

4DGL (3D)

Secondary accessions: B0UXA9 P07312 P13862 Q4VX47

Explore the universe of human proteins at neXtProt for CSNK2B: NX_P67870

Post-translational modifications:

Phosphorylated by alpha subunit¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P67870

CSNK2B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001311.3

ENSEMBL proteins:

ENSP00000365046 ENSP00000365042 ENSP00000365025 ENSP00000365026

Reactome Protein details: P67870
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for CSNK2B
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	19233263
GO:0005829	cytosol	TAS	--
GO:0005886	colocalizes with plasma membrane	IDA	19233263
GO:0005956	protein kinase CK2 complex	NAS	2666134

CSNK2B for ontologies About GeneDecksing

CSNK2B Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CSNK2B
	R&D Systems Antibodies for CSNK2B (Casein Kinase 2 beta)
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	GenScript Custom Superior Antibodies Services for CSNK2B
	Novus Biologicals CSNK2B Antibodies
	Abcam antibodies for CSNK2B
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for CSNK2B

Assay Products for CSNK2B:

	EMD Millipore Kits and Assays for the Analysis of CSNK2B
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CSNK2B
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CSNK2B for domains About GeneDecksing

3 InterPro domains/families:

IPR016149 Casein_kin_II_reg-sub_a-hlx

IPR016150 Casein_kin_II_reg-sub_b-sht

IPR000704 Casein_kinase_II_reg-sub

Graphical View of Domain Structure for InterPro Entry P67870

ProtoNet protein and cluster: P67870

1 Blocks protein family: IPB000704 Casein kinase II

UniProtKB/Swiss-Prot: CSK2B_HUMAN, P67870

Similarity: Belongs to the casein kinase 2 subunit beta family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CSK2B_HUMAN, P67870

Function: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic

activity of the alpha subunit

Genatlas biochemistry entry for CSNK2B:

caseine kinase II,beta unit,likely involved in regulation of cell growth

miRNA Products:		OriGene 3'-UTR Clone: CSNK2B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSNK2B
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CSNK2B:
		hsa-miR-548am hsa-miR-548d-3p hsa-miR-548x hsa-miR-205* hsa-miR-1260b hsa-miR-32* hsa-miR-1260 hsa-miR-548aa

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSNK2B (see all 7) OriGene shRNA RFP: CSNK2B OriGene siRNA: CSNK2B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSNK2B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CSNK2B

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2B

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004674	contributes to protein serine/threonine kinase activity	TAS	1856204
GO:0005102	receptor binding	IPI	19592636
GO:0005515	protein binding	IPI	--
GO:0008134	transcription factor binding	IPI	19324893
GO:0016301	kinase activity	--	--

CSNK2B for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for CSNK2B:

G0/1 arrest

Increased G1 DNA content

Increased cell death in HCC-19

Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-out Csnk2b^tm1.2Bb for CSNK2B
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Csnk2b):

behavior/neurological

embryogenesis

growth/size

mortality/aging

nervous system

CSNK2B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69			Signal transduction by L1	0.12

Development_CNTF receptor signaling

	Cell adhesion_PLAU signaling	0.35			Translation _Regulation of EIF2 activity	0.25
	Cell adhesion PLAU signaling	0.35			Translation Regulation activity of EIF2	0.25

M Phase

M Phase

1.00

Mitotic M-M/G1 phases

0.88

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Non-homologous end-joining

DNA damage NHEJ mechanisms of DSBs repair

0.36

DNA damage_NHEJ mechanisms of DSBs repair

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CSNK2B

	Translation Regulation activity of EIF2
	Cell adhesion PLAU signaling
	DNA damage NHEJ mechanisms of DSBs repair

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSNK2B

	NF-KappaB (p50-p65) Pathway
	Erythropoietin Pathway

1 Tocris Bioscience Pathway for CSNK2B

NF-kappaB Pathway

4 GeneGo (Thomson Reuters) Pathways for CSNK2B

	Cell adhesion PLAU signaling
	DNA damage NHEJ mechanisms of DSBs repair
	Translation Regulation of EIF2 activity
	Regulation of CFTR activity (norm and CF)

3 BioSystems Pathways for CSNK2B

	TNF-alpha/NF-kB Signaling Pathway
	Wnt Signaling Pathway NetPath
	ALK1 signaling events

5/10 Reactome Pathways for CSNK2B (see all 10)

	L1CAM interactions
	Developmental Biology
	Mitotic Prometaphase
	Cell Cycle
	M Phase

5 Kegg Pathways (Kegg details for CSNK2B):

	Ribosome biogenesis in eukaryotes
	Wnt signaling pathway
	Adherens junction
	Tight junction
	Measles

CSNK2B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CSNK2B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/199 Interacting proteins for CSNK2B (P67870^{1, 2, 3} ENSP00000365025⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 199)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CSNK2A2	P19784¹^,²^,³, ENSP00000262506⁴	EBI-3866975,EBI-347451 MINT-62609 MINT-62783 MINT-62707 I2D: score=6 STRING: ENSP00000262506
CHEK1	O14757²^,³, ENSP00000278916⁴	MINT-51390 MINT-51392 MINT-51394 MINT-51391 MINT-51393 I2D: score=2 STRING: ENSP00000278916
SIRT1	Q96EB6²^,³	MINT-8206425 MINT-8206396 MINT-8206373 MINT-8206385 MINT-8206442 MINT-8206407 I2D: score=1
RPL5	P46777²^,³, ENSP00000359345⁴	MINT-62613 MINT-62787 MINT-62711 I2D: score=6 STRING: ENSP00000359345
ZNHIT1	O43257²^,³, ENSP00000304593⁴	MINT-62614 MINT-62712 MINT-62788 I2D: score=4 STRING: ENSP00000304593

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	2513884
GO:0007411	axon guidance	TAS	--
GO:0008285	negative regulation of cell proliferation	TAS	19324893
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IDA	19592636
GO:0016055	Wnt receptor signaling pathway	IEA	--

CSNK2B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CSNK2B for compounds About GeneDecksing

EMD Millipore small molecules for CSNK2B:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for CSNK2B available from Tocris Bioscience About this table

Compound	Action	CAS #
TMCB	Dual-kinase inhibitor; inhibits CK2 and ERK8	[905105-89-7]
TBB	Selective cell-permeable CK2 inhibitor	[17374-26-4]
Ellagic acid	Selective inhibitor of CK2. Also inhibits glutathione S-transferase	[476-66-4]

2 HMDB Compounds for CSNK2B About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

10/21 Novoseek chemical compound relationships for CSNK2B gene (see all 21) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lipovitellin	82.6	3	11513694 (1), 8502607 (1), 9037702 (1)
kemptide	65.1	3	8527311 (3)
phosphoserine	62.9	2	1791469 (1), 1965857 (1)
threonine	53.9	3	1295885 (2), 7864634 (1)
serine	48.9	6	1791469 (2), 1590772 (1), 1295885 (1), 12551973 (1) (see all 5)
hydroxyapatite	44.7	41	2170349 (6), 1659832 (4), 16851965 (4), 16055080 (2) (see all 5)
gtp	40	3	7735321 (1), 11853545 (1), 1295885 (1)
atp	35.4	5	7735321 (1), 11853545 (1), 1295885 (1), 8527311 (1) (see all 5)
nacl	35.3	1	7735321 (1)
protamine	31.1	2	1311309 (1), 7864634 (1)

Search CenterWatch for drugs/clinical trials and news about CSNK2B / CSK2B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CSNK2B gene:

NM_001320.5

Unigene Cluster for CSNK2B:

Casein kinase 2, beta polypeptide

Hs.73527 [show with all ESTs]

Unigene Representative Sequence: BM912855

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375885 ENST00000375882(uc003nvr.1) ENST00000468255(uc010jta.1 uc021yuv.1)

ENST00000465481 ENST00000481269 ENST00000496869 ENST00000475875(uc010jsz.1)

ENST00000375865 ENST00000375866

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSNK2B
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CSNK2B:
		hsa-miR-548am hsa-miR-548d-3p hsa-miR-548x hsa-miR-205* hsa-miR-1260b hsa-miR-32* hsa-miR-1260 hsa-miR-548aa

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSNK2B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSNK2B

Additional cDNA sequence:

AK300671.1 AK308742.1 AK310551.1 AK310954.1 AK311860.1 AY113186.1 BC112017.1 BC112019.1

CR541699.1 X16312.1 X16937.1

23 DOTS entries:

DT.100803539 DT.40250887 DT.100660707 DT.91854909 DT.95365897 DT.100753713 DT.91855355 DT.100749818

DT.91855284 DT.95175640 DT.121325864 DT.121325866 DT.95142818 DT.121325878 DT.100044302 DT.100863724

DT.121325850 DT.121325906 DT.95288045 DT.95365932 DT.95365998 DT.100732064 DT.95365933

1 AceView cDNA sequence:

AJ711351

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CSNK2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCATCCCG

About this image

CSNK2B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Mandibular Condyle

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CSNK2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CSNK2B

SOURCE GeneReport for Unigene cluster: Hs.73527

SABiosciences Expression via Pathway-Focused PCR Arrays including CSNK2B:

Adherens Junctions in human mouse rat

Tight Junctions in human mouse rat

Polycomb & Trithorax Complexes in human mouse rat

EGF / PDGF Signaling Pathway in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSNK2B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK2B gene from 8/39 species (see all 39) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CSNK2B⁶	--	100(a)	1 → many	2(193368790-193374398)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1152²	X.laevis mRNA for beta subunit of casein kinase II	80.95(n)		X62376.1
zebrafish (Danio rerio)	Actinopterygii	ck2b²	casein kinase 2 beta	85.32(n)		30428 NM_131187.1
fruit fly (Drosophila melanogaster)	Insecta	CkII&bgr;³ CkIIbeta¹	protein amino acid phosphorylation protein kinase³ Casein kinase II beta subunit¹	89(a) (best of 4)³ 74.73(n)¹ 88.37(a)¹		10E3³ 32132¹ NM_206692.2¹ NP_996415.1¹
worm (Caenorhabditis elegans)	Secernentea	kin-10^{1 , 3}	KIN-10 casein kinase³ Protein KIN-10¹	81(a) (best of 2)³ 70.22(n)¹ 81.73(a)¹		I(8297260-8298873)³ 172610¹ NM_059853.2¹ NP_492254.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CKB2(YOR039W)⁴ CKB2¹	Beta' regulatory subunit of casein kinase 2 (CK2), more⁴ Ckb2p¹	51.78(n)¹ 47.57(a)¹		15(405768-406544)⁴ 854204^{1, 4} NP_014682.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	CKB4¹	casein kinase 2, beta polypeptide	56.25(n) 57.81(a)		819076 NM_130032.2 NP_181996.1
rice (Oryza sativa)	Liliopsida	Os.11223²	Oryza sativa (japonica cultivar-group) putative casein more	71.23(n)		AK111555.1

ENSEMBL Gene Tree for CSNK2B (if available)
TreeFam Gene Tree for CSNK2B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CSNK2B gene

ENSG00000263020²

CSNK2B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199937819^1,2		--	31632272(+)	`GAACTA/GAGAAA`	6	--	ut5¹ us2k¹		0	--	--	--	--
rs144821605^1,2		--	31632329(+)	`GTGACA/CCTGTA`	5	--	ut5¹		0	--	--	--	--
rs80012618^1,2	C	--	31632389(+)	`CACTTC/TCCTGC`	6	--	int¹ us2k¹		0	--	--	--	--
rs147546957^1,2		--	31632443(+)	`GAGAGA/GGACTT`	5	--	int¹		0	--	--	--	--
rs56194675^1,2	C,	--	31632527(+)	`TGTCCG/AGAGGT`	6	--	int¹ us2k¹		1		WA	2
rs13930^1,2	C	--	31632651(-)	`GAAGAC/ATTAAA`	6	--	ut5¹ us2k¹		1		NA	2
rs2295665^1,2	C,F,H,	--	31632686(-)	`TGTTTG/AGGAAG`	6	--	ut5¹ us2k¹ trp³		27		EA NA NS CSA WA	4646
rs62395807^1,2		--	31632808(+)	`TCAAAA/TAGCCA`	6	--	ut5¹ int¹ us2k¹		0	--	--	--	--
rs35377600^1,2	C,F,	--	31632899(+)	`AGCTCC/TGGGTT`	6	--	int¹ ut5¹ us2k¹		4		NS WA NA	322
rs118127996^1,2		--	31632900(+)	`GCTCCG/AGGTTC`	5	--	int¹ ut5¹		1		EA	120

HapMap Linkage Disequilibrium report for CSNK2B (31633013 - 31638120 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CSNK2B: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSNK2B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CSNK2B for disorders           About GeneDecksing

OMIM gene information: 115441    OMIM disorders: --

20/29 diseases for CSNK2B (see all 29):    About MalaCards

egg allergy adenomatous polyposis coli xeroderma pigmentosum theileriasis

laryngeal squamous cell carcinoma systemic lupus erythematosus squamous cell carcinoma orchitis

lupus erythematosus macular degeneration chronic lymphocytic leukemia herpes simplex

lymphocytic leukemia polyposis laryngitis rheumatoid arthritis

teratocarcinoma endometrial carcinoma gout parkinson's disease

Human Genome Epidemiology (HuGE) Navigator: CSNK2B (6 documents)

Export disorders for CSNK2B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CSNK2B gene, integrated from 9 sources (see all 278):
(articles sorted by number of sources associating them with CSNK2B)

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Structure of the gene encoding human casein kinase II subunit beta. (PubMed id 1856204)^{1, 2, 9} Voss A.... Pyerin W. (1991)
Assignment of the human casein kinase II beta-subunit gene to 6p12----p21. (PubMed id 2276748)^{1, 3, 9} Yang-Feng T.L....Canaani D. (1990)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)^{1, 2} Xie T.... Hood L. (2003)
p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. (PubMed id 12393879)^{1, 2} Keller D.M. and Lu H. (2002)
Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line. (PubMed id 12102635)^{1, 2} Singh L.S. and Kalafatis M. (2002)
Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C. (PubMed id 11298324)^{1, 2} Ritter M.... Schmitz G. (2001)
A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. (PubMed id 11239457)^{1, 2} Keller D.M....Lu H. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1460	HGNC: 2460	AceView: CSNK2B	Ensembl:ENSG00000204435	euGenes: HUgn1460
ECgene: CSNK2B	Kegg: 1460	H-InvDB: CSNK2B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CSNK2B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CSNK2B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CSNK2B gene
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Patent Information for CSNK2B gene:
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CSNK2B Gene

casein kinase 2, beta polypeptide

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CSNK2B Gene

casein kinase 2, beta polypeptide

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