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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSNK2A3 Gene

protein-coding   GIFtS: 29
GCID: GC11M011373

Casein Kinase 2, Alpha 3 Polypeptide

(Previous names: casein kinase 2, alpha 1 polypeptide pseudogene)
(Previous symbol: CSNK2A1P)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 8.2

Aliases
Casein Kinase 2, Alpha 3 Polypeptide1 2     EC 2.7.11.13
CSNK2A1P1 2 3     Casein Kinase II Alpha 1 Polypeptide Pseudogene3
Casein Kinase 2, Alpha 1 Polypeptide Pseudogene1 2     CK II Alpha 33
Casein Kinase 2, Alpha 1 Polypeptide-Like2     

External Ids:    HGNC: 24581   Entrez Gene: 2831062   Ensembl: ENSG000002545987   UniProtKB: Q8NEV13   
ORGUL members:    fRNAdb10:FR019783      
H-InvDB12: HIT000461867_04    
NONCODE14:n405455      
RNAdb15:EVF46683    

Export aliases for CSNK2A3 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSNK2A3 Gene:
This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a
serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha
subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility
to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a
protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). (provided by RefSeq, Feb
2012)

GeneCards Summary for CSNK2A3 Gene: 
CSNK2A3 (casein kinase 2, alpha 3 polypeptide) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CSNK2A3 include lung cancer, and among its related super-pathways are Wnt signaling pathway. An important paralog of this gene is CSNK2A1.

UniProtKB/Swiss-Prot: CSK23_HUMAN, Q8NEV1
Function: Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that
phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or
threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating
expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer
development and progression



fRNAdb sequence ontology for CSNK2A3:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for CSNK2A3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CSNK2A3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CSNK2A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK2A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3   Ensembl cytogenetic band:  11p15.3   HGNC cytogenetic band: 11p15.3

CSNK2A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK2A3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M011373:  view genomic region     (about GC identifiers)

Start:
11,373,321 bp from pter      End:
11,374,904 bp from pter
Size:
1,584 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CSNK2A3

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CSK23_HUMAN, Q8NEV1 (See protein sequence)
Recommended Name: Casein kinase II subunit alpha 3  
Size: 391 amino acids; 45220 Da
Subunit: Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory
subunits (beta chains) (By similarity). Interacts with PML

Explore the universe of human proteins at neXtProt for CSNK2A3: NX_Q8NEV1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NEV1

  • CSNK2A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001243615.1  
    ENSEMBL proteins: 
     ENSP00000473553  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8NEV1

    ProtoNet protein and cluster: Q8NEV1

    UniProtKB/Swiss-Prot: CSK23_HUMAN, Q8NEV1
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily
    Similarity: Contains 1 protein kinase domain


    CSNK2A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSK23_HUMAN, Q8NEV1
    Function: Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that
    phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or
    threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating
    expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer
    development and progression
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding ----
         
    CSNK2A3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CSNK2A3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CSNK2A3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt Signaling Pathway NetPath0.37
    2BDNF signaling pathway
    BDNF signaling pathway
    3TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    3 BioSystems Pathways for CSNK2A3
        BDNF signaling pathway
    Wnt Signaling Pathway NetPath
    TNF-alpha/NF-kB Signaling Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CSNK2A3

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0008284positive regulation of cell proliferation ----
    GO:0030307positive regulation of cell growth ----
    GO:0045732positive regulation of protein catabolic process ----

    CSNK2A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CSNK2A3 (CSK23)

    Search CenterWatch for drugs/clinical trials and news about CSNK2A3 / CSK23

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for CSNK2A3 gene: 
    NM_001256686.1  

    Unigene Clusters for CSNK2A3:

    Casein kinase 2, alpha 3 polypeptide
    Hs.654675  [show with all ESTs], Hs.741126
    Unigene Representative Sequences: AY112721, NM_001256686
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000528848(uc001mjp.3)
    miRNA
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    9 DOTS entries:

    DT.101957241  DT.99935781  DT.456148  DT.100821379  DT.100821391  DT.120821972  DT.120821992  DT.91745722 
    DT.95258004 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSNK2A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CSNK2A3 Expression
    About this image


    SOURCE GeneReport for Unigene clusters: Hs.654675 Hs.741126

    UniProtKB/Swiss-Prot: CSK23_HUMAN, Q8NEV1
    Tissue specificity: Detected in blood platelets and megakaryocyte cell lines. Poorly expressed in lung. Highly
    expressed in lung tumor tissues

        SABiosciences Custom PCR Arrays for CSNK2A3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CSNK2A3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CSNK2A16
    Casein kinase II subunit alpha
    96(a)
    possible ortholog
    20(10279230-10302521)
    lizard
    (Anolis carolinensis)
    Reptilia CSNK2A16
    --
    Uncharacterized protein
    95(a)
    88(a)
    1 ↔ many
    possible ortholog
    GL343346.1(62790-83370)
    1(259625956-259653886)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:865986
    ck2a16
    (see all 3)
    casein kinase 2 alpha 1
    (see all 3)
    88(a)
    86(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    19(3697800-3795238)
    16(33740930-33756680)
    fruit fly
    (Drosophila melanogaster)
    Insecta CkIIalpha6
    casein kinase IIalpha
    86(a)
    1 → many
    3L(23090439-23096560)
    worm
    (Caenorhabditis elegans)
    Secernentea kin-36
    Casein kinase II subunit alpha
    77(a)
    1 → many
    I(10734022-10736607)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CKA16
    Alpha catalytic subunit of casein kinase 2 (CK2), ...
    56(a)
    1 → many
    IX(287790-288908)
            Species with no ortholog for CSNK2A3

    ENSEMBL Gene Tree for CSNK2A3 (if available)
    TreeFam Gene Tree for CSNK2A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSNK2A3 gene
    CSNK2A12  CSNK2A22  
    18/32 SIMAP similar genes for CSNK2A3 using alignment to 1 protein entry:     CSK23_HUMAN(see all similar genes):
    CSNK2A1    CSNK2A2    CSNK1A1    RPS6KA1    DYRK4    PHKG2
    RPS6KA2    MAPK8    CDK7    BRSK2    CDC2    MAPK3
    NEK9    ULK1    CDK3    CDKL1    CDK1    CDK2

    CSNK2A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in CSNK2A3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0692254
    A lung carcinoma sample4--see VAR_0692252 I T mis40--------

    HapMap Linkage Disequilibrium report for CSNK2A3 (11373321 - 11374904 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CSNK2A3: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CSNK2A3
    DNA2.0 Custom Variant and Variant Library Synthesis for CSNK2A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CSNK2A3:    About MalaCards
    lung cancer    


    CSNK2A3 for disorders           About GeneDecksing


    Export disorders for CSNK2A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSNK2A3 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with CSNK2A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional polymorphism of the CK2alpha intronless ge ne plays oncogenic roles in lung cancer. (PubMed id 20625391)1, 2, 3 Hung M.S....You L. (2010)
    2. Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line. (PubMed id 12102635)1, 2, 3 Singh L.S. and Kalafatis M. (2002)
    3. Human casein kinase II subunit alpha: sequence of a processed (pseudo)gene and its localization on chromosome 11. (PubMed id 1610905)1, 2, 3 Wirkner U....Pyerin W. (1992)
    4. Structure and sequence of an intronless gene for human casein kinase II-alpha subunit. (PubMed id 8420794)1, 2 Devilat I. and Carvallo P. (1993)
    5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    6. Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation. (PubMed id 15684395)1 Trembley J.H.... Mayeda A. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
    8. Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2. (PubMed id 14646071)1 Pechkova E.... Nicolini C. (2003)
    9. Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis. (PubMed id 14522971)1 Fukuda N.... Takahashi M. (2003)
    10. Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit. (PubMed id 12860116)1 Ermakova I.... Niefind K. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283106 HGNC: 2458 Ensembl:ENSG00000254598 euGenes: HUgn283106 ECgene: CSNK2A3
    H-InvDB: CSNK2A3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSNK2A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CSNK2A3 gene:
    Search GeneIP for patents involving CSNK2A3

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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