Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CSNK2A3 Gene

protein-coding   GIFtS: 29
GCID: GC11M011373

Casein Kinase 2, Alpha 3 Polypeptide

(Previous names: casein kinase 2, alpha 1 polypeptide pseudogene)
(Previous symbol: CSNK2A1P)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Casein Kinase 2, Alpha 3 Polypeptide1 2     EC 2.7.11.13
CSNK2A1P1 2 3     Casein Kinase II Alpha 1 Polypeptide Pseudogene3
Casein Kinase 2, Alpha 1 Polypeptide Pseudogene1 2     CK II Alpha 33
Casein Kinase 2, Alpha 1 Polypeptide-Like2     

External Ids:    HGNC: 24581   Entrez Gene: 2831062   Ensembl: ENSG000002545987   UniProtKB: Q8NEV13   

Export aliases for CSNK2A3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CSNK2A3 Gene:
This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a
serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha
subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility
to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a
protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). (provided by RefSeq, Feb
2012)

GeneCards Summary for CSNK2A3 Gene:
CSNK2A3 (casein kinase 2, alpha 3 polypeptide) is a protein-coding gene. Diseases associated with CSNK2A3 include lung cancer. An important paralog of this gene is CSNK2A1.

UniProtKB/Swiss-Prot: CSK23_HUMAN, Q8NEV1
Function: Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that
phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or
threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating
expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer
development and progression




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CSNK2A3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CSNK2A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSNK2A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3   Ensembl cytogenetic band:  11p15.3   HGNC cytogenetic band: 11p15.3

CSNK2A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK2A3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M011373:  view genomic region     (about GC identifiers)

Start:
11,373,321 bp from pter      End:
11,374,904 bp from pter
Size:
1,584 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CSNK2A3

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CSK23_HUMAN, Q8NEV1 (See protein sequence)
Recommended Name: Casein kinase II subunit alpha 3  
Size: 391 amino acids; 45220 Da
Subunit: Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory
subunits (beta chains) (By similarity). Interacts with PML

Explore the universe of human proteins at neXtProt for CSNK2A3: NX_Q8NEV1

Post-translational modifications: 

  • Ubiquitination2 at Lys83, Lys102, Lys122, Lys303
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_001243615.1  
    ENSEMBL proteins: 
     ENSP00000473553  

    CSNK2A3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CSNK2A3
    GenScript Custom Purified and Recombinant Proteins Services for CSNK2A3
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CSNK2A3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CSNK2A3
    Search for Antibodies for CSNK2A3 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for CSNK2A3
    Search LSBio for Antibodies for CSNK2A3

    CSNK2A3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CSNK2A3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CSNK2A3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q8NEV1

    ProtoNet protein and cluster: Q8NEV1

    UniProtKB/Swiss-Prot: CSK23_HUMAN, Q8NEV1
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily
    Similarity: Contains 1 protein kinase domain


    CSNK2A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSK23_HUMAN, Q8NEV1
    Function: Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that
    phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or
    threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating
    expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer
    development and progression
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding ----
         
    CSNK2A3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CSNK2A3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CSNK2A3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSNK2A3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSNK2A3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CSNK2A3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CSNK2A3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse OriGene RNAi
    Predesigned siRNA for gene silencing in human, mouse, rat CSNK2A3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CSNK2A3

    Clone
    Products:
         
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CSNK2A3
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSNK2A3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CSNK2A3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CSNK2A3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CSNK2A3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2A3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CSNK2A3 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt Signaling Pathway NetPath0.37
    2TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    3BDNF signaling pathway
    BDNF signaling pathway


    3 BioSystems Pathways for CSNK2A3
        BDNF signaling pathway
    Wnt Signaling Pathway NetPath
    TNF-alpha/NF-kB Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSNK2A3
    Interactions:

        Search GeneGlobe Interaction Network for CSNK2A3

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0008284positive regulation of cell proliferation ----
    GO:0030307positive regulation of cell growth ----
    GO:0045732positive regulation of protein catabolic process ----

    CSNK2A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CSNK2A3 (CSK23)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CSNK2A3 gene: 
    NM_001256686.1  

    Unigene Cluster for CSNK2A3:

    Casein kinase 2, alpha 3 polypeptide
    Hs.654675  [show with all ESTs]
    Unigene Representative Sequence: AY112721
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000528848(uc001mjp.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CSNK2A3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CSNK2A3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse OriGene RNAi
    Predesigned siRNA for gene silencing in human, mouse, rat CSNK2A3
    Clone
    Products:
         
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CSNK2A3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSNK2A3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CSNK2A3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CSNK2A3
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CSNK2A3
      Search QuantiTect SYBR Green Assays in human, mouse, rat CSNK2A3
      QuantiFast Probe-based Assays in human, mouse, rat CSNK2A3

    Additional mRNA sequence: AY112721.1 

    9 DOTS entries:

    DT.101957241  DT.99935781  DT.456148  DT.100821379  DT.100821391  DT.120821972  DT.120821992  DT.91745722 
    DT.95258004 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CSNK2A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CSNK2A3 Expression
    About this image

    CSNK2A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.654675

    UniProtKB/Swiss-Prot: CSK23_HUMAN, Q8NEV1
    Tissue specificity: Detected in blood platelets and megakaryocyte cell lines. Poorly expressed in lung. Highly
    expressed in lung tumor tissues

        Custom PCR Arrays for CSNK2A3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CSNK2A3
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CSNK2A3
    Search QuantiTect SYBR Green Assays in human, mouse, rat CSNK2A3
    QuantiFast Probe-based Assays in human, mouse, rat CSNK2A3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSNK2A3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CSNK2A16
    Gallus gallus casein kinase 2, alpha 1 polypeptide...
    96(a)
    1 → many
    20(10279230-10302521) ENSGALG00000006197
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    95(a)
    1 → many
    GL343346.1(62790-83370)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:865981 zgc:86598 76.84(n)
    88.21(a)
      415254  NM_001002164.1  NP_001002164.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CkIIalpha6
    casein kinase IIalpha
    85(a)
    1 → many
    3L(23090439-23096560)
    worm
    (Caenorhabditis elegans)
    Secernentea kin-36
    Protein KIN-3 (kin-3) mRNA, complete cds
    77(a)
    1 → many
    I(10734022-10736607) WBGene00002191
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CKA26
    Alpha' catalytic subunit of casein kinase 2 (CK2),...
    57(a)
    1 → many
    XV(441534-442553) YOR061W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CKA11 CKA1 65.76(n)
    73.03(a)
      836873  NM_126138.3  NP_201539.2 
    rice
    (Oryza sativa)
    Liliopsida Os07g01144001 Os07g0114400 67.07(n)
    76.29(a)
      4342248  NM_001065287.1  NP_001058752.1 
            Species with no ortholog for CSNK2A3

    ENSEMBL Gene Tree for CSNK2A3 (if available)
    TreeFam Gene Tree for CSNK2A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CSNK2A3 gene
    CSNK2A12  CSNK2A22  
    Selected SIMAP similar genes for CSNK2A3 using alignment to 1 protein entry:     CSK23_HUMAN(see all similar genes):
    CSNK2A1    CSNK2A2    CSNK1A1    RPS6KA1    DYRK4    PHKG2
    RPS6KA2    MAPK8    CDK7    BRSK2    CDC2    MAPK3
    NEK9    ULK1    CDK3    CDKL1    CDK1    CDK2

    CSNK2A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    1 SNPs for CSNK2A3    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0692254
    A lung carcinoma sample4--see VAR_0692252 I T mis40--------

    HapMap Linkage Disequilibrium report for CSNK2A3 (11373321 - 11374904 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CSNK2A3: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CSNK2A3
    DNA2.0 Custom Variant and Variant Library Synthesis for CSNK2A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease for CSNK2A3:    
    About MalaCards
    lung cancer


    CSNK2A3 for disorders           About GeneDecksing


    Export disorders for CSNK2A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CSNK2A3 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with CSNK2A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. (PubMed id 20625391)1, 2, 3 Hung M.S.... You L. (PLoS ONE 2010)
    2. Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line. (PubMed id 12102635)1, 2, 3 Singh L.S. and Kalafatis M. (Biochemistry 2002)
    3. Human casein kinase II subunit alpha: sequence of a processed (pseudo)gene and its localization on chromosome 11. (PubMed id 1610905)1, 2, 3 Wirkner U.... Pyerin W. (Biochim. Biophys. Acta 1992)
    4. Structure and sequence of an intronless gene for human casein kinase II-alpha subunit. (PubMed id 8420794)1, 2 Devilat I. and Carvallo P. (FEBS Lett. 1993)
    5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    6. Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation. (PubMed id 15684395)1 Trembley J.H.... Mayeda A. (Mol. Cell. Biol. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2. (PubMed id 14646071)1 Pechkova E.... Nicolini C. (Acta Crystallogr. D 2003)
    9. Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis. (PubMed id 14522971)1 Fukuda N.... Takahashi M. (J. Biol. Chem. 2003)
    10. Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit. (PubMed id 12860116)1 Ermakova I.... Niefind K. (J. Mol. Biol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 283106 HGNC: 2458 Ensembl:ENSG00000254598 euGenes: HUgn283106 ECgene: CSNK2A3
    H-InvDB: CSNK2A3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CSNK2A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CSNK2A3 gene:
    Search GeneIP for patents involving CSNK2A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   Browse OriGene RNAi products  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   Browse OriGene clones  
     OriGene qSTAR qPCR primer pairs in human, mouse for CSNK2A3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CSNK2A3   OriGene Custom Protein Services for CSNK2A3  

     
     
     Block miRNA regulation of human, mouse, rat CSNK2A3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CSNK2A3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSNK2A3 Predesigned siRNA for gene silencing in human, mouse, rat CSNK2A3
     QuantiFast Probe-based Assays in human, mouse, rat CSNK2A3 Search QuantiTect SYBR Green Assays in human, mouse, rat CSNK2A3
     Custom PCR Arrays for CSNK2A3 Search Chromatin IP Primers for CSNK2A3
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CSNK2A3 Search GeneGlobe Interaction Network for CSNK2A3
     Search Regulatory tfbs for CSNK2A3
     GenScript Custom Purified and Recombinant Proteins Services for CSNK2A3 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CSNK2A3
     GenScript Custom Assay Services for CSNK2A3 GenScript Custom overexpressing Cell Line Services for CSNK2A3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CSNK2A3 (CSK23)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Search for Antibodies for CSNK2A3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CSNK2A3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for CSNK2A3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2A3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CSNK2A3
     Browse SwitchGear Promoter luciferase reporter plasmids for CSNK2A3
     Search ThermoFisher Antibodies for CSNK2A3
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CSNK2A3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CSNK2A3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CSNK2A3
     Search LSBio for Antibodies for CSNK2A3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CSNK2A3 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4