Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CSNK2A3 Gene

Aliases for CSNK2A3 Gene

  • Casein Kinase 2 Alpha 3 2 3
  • Casein Kinase 2, Alpha 3 Polypeptide 2 3 5
  • Casein Kinase 2, Alpha 1 Polypeptide Pseudogene 2 3
  • CSNK2A1P 3 4
  • Casein Kinase II Alpha 1 Polypeptide Pseudogene 4
  • CK II Alpha 3 4
  • EC 2.7.11.1 4

External Ids for CSNK2A3 Gene

Previous HGNC Symbols for CSNK2A3 Gene

  • CSNK2A1P

Summaries for CSNK2A3 Gene

Entrez Gene Summary for CSNK2A3 Gene

  • This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012]

GeneCards Summary for CSNK2A3 Gene

CSNK2A3 (Casein Kinase 2 Alpha 3) is a Protein Coding gene. Among its related pathways are Adherens junction and Epstein-Barr virus infection. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK2A2.

UniProtKB/Swiss-Prot for CSNK2A3 Gene

  • Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK2A3 Gene

Genomics for CSNK2A3 Gene

Regulatory Elements for CSNK2A3 Gene

Enhancers for CSNK2A3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CSNK2A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CSNK2A3 Gene

Chromosome:
11
Start:
11,351,942 bp from pter
End:
11,353,357 bp from pter
Size:
1,416 bases
Orientation:
Minus strand

Genomic View for CSNK2A3 Gene

Genes around CSNK2A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK2A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK2A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK2A3 Gene

Proteins for CSNK2A3 Gene

  • Protein details for CSNK2A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEV1-CSK23_HUMAN
    Recommended name:
    Casein kinase II subunit alpha 3
    Protein Accession:
    Q8NEV1

    Protein attributes for CSNK2A3 Gene

    Size:
    391 amino acids
    Molecular mass:
    45220 Da
    Quaternary structure:
    • Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha chain) and two regulatory subunits (beta chains) (By similarity). Interacts with PML.

neXtProt entry for CSNK2A3 Gene

Proteomics data for CSNK2A3 Gene at MOPED

Post-translational modifications for CSNK2A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSNK2A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CSNK2A3 Gene

Domains & Families for CSNK2A3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEV1

UniProtKB/Swiss-Prot:

CSK23_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
genes like me logo Genes that share domains with CSNK2A3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CSNK2A3 Gene

Function for CSNK2A3 Gene

Molecular function for CSNK2A3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.

Enzyme Numbers (IUBMB) for CSNK2A3 Gene

Gene Ontology (GO) - Molecular Function for CSNK2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IDA --
GO:0008013 beta-catenin binding IEA --
genes like me logo Genes that share ontologies with CSNK2A3: view
genes like me logo Genes that share phenotypes with CSNK2A3: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CSNK2A3 Gene

Localization for CSNK2A3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CSNK2A3 Gene

Pathways & Interactions for CSNK2A3 Gene

genes like me logo Genes that share pathways with CSNK2A3: view

Interacting Proteins for CSNK2A3 Gene

Gene Ontology (GO) - Biological Process for CSNK2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with CSNK2A3: view

No data available for SIGNOR curated interactions for CSNK2A3 Gene

Drugs & Compounds for CSNK2A3 Gene

(3) Drugs for CSNK2A3 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ellagic acid Investigational Pharma Casein kinase 2 (CK2) inhibitor, Selective inhibitor of CK2. Also inhibits glutathione S-transferase 0
CX-4945 (Silmitasertib) Pharma CK2 inhibitor 0
TTP 22 Pharma CK2 inhibitor, High affinity, selective CK2 inhibitor 0

(3) ApexBio Compounds for CSNK2A3 Gene

Compound Action Cas Number
CX-4945 (Silmitasertib) CK2 inhibitor 1009820-21-6
Ellagic acid Casein kinase 2 (CK2) inhibitor 476-66-4
TTP 22 CK2 inhibitor 329907-28-0
genes like me logo Genes that share compounds with CSNK2A3: view

Transcripts for CSNK2A3 Gene

mRNA/cDNA for CSNK2A3 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK2A3 Gene

No ASD Table

Relevant External Links for CSNK2A3 Gene

GeneLoc Exon Structure for
CSNK2A3
ECgene alternative splicing isoforms for
CSNK2A3

Expression for CSNK2A3 Gene

mRNA expression in normal human tissues for CSNK2A3 Gene

SOURCE GeneReport for Unigene cluster for CSNK2A3 Gene Hs.654675

mRNA Expression by UniProt/SwissProt for CSNK2A3 Gene

Q8NEV1-CSK23_HUMAN
Tissue specificity: Detected in blood platelets and megakaryocyte cell lines. Poorly expressed in lung. Highly expressed in lung tumor tissues.
genes like me logo Genes that share expression patterns with CSNK2A3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CSNK2A3 Gene

Orthologs for CSNK2A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK2A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSNK2A1 36
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Csnk2a1 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CSNK2A3 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves CSNK2A1 36
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 95 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:86598 35
  • 76.84 (n)
  • 88.21 (a)
CU928126.3 36
  • 80 (a)
ManyToMany
zgc:86598 36
  • 87 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CkIIalpha 36
  • 85 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-3 36
  • 77 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKA2 36
  • 57 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CKA1 35
  • 65.76 (n)
  • 73.03 (a)
rice
(Oryza sativa)
Liliopsida Os07g0114400 35
  • 67.07 (n)
  • 76.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11074 36
  • 85 (a)
OneToMany
Species with no ortholog for CSNK2A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CSNK2A3 Gene

ENSEMBL:
Gene Tree for CSNK2A3 (if available)
TreeFam:
Gene Tree for CSNK2A3 (if available)

Paralogs for CSNK2A3 Gene

Paralogs for CSNK2A3 Gene

genes like me logo Genes that share paralogs with CSNK2A3: view

Variants for CSNK2A3 Gene

Sequence variations from dbSNP and Humsavar for CSNK2A3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_069225 A lung carcinoma sample

Variation tolerance for CSNK2A3 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.78; 93.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK2A3 Gene

HapMap Linkage Disequilibrium report
CSNK2A3
Human Gene Mutation Database (HGMD)
CSNK2A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CSNK2A3 Gene

Disorders for CSNK2A3 Gene

Relevant External Links for CSNK2A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK2A3

No disorders were found for CSNK2A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK2A3 Gene

Publications for CSNK2A3 Gene

  1. Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. (PMID: 20625391) Hung M.S. … You L. (PLoS ONE 2010) 2 3 4 67
  2. Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line. (PMID: 12102635) Singh L.S. … Kalafatis M. (Biochemistry 2002) 2 3
  3. Human casein kinase II subunit alpha: sequence of a processed (pseudo)gene and its localization on chromosome 11. (PMID: 1610905) Wirkner U. … Pyerin W. (Biochim. Biophys. Acta 1992) 2 3
  4. Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation. (PMID: 15684395) Trembley J.H. … Mayeda A. (Mol. Cell. Biol. 2005) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for CSNK2A3 Gene

Sources for CSNK2A3 Gene

Content