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Aliases for CSNK2A3 Gene

Aliases for CSNK2A3 Gene

  • Casein Kinase 2, Alpha 3 Polypeptide 2 3
  • Casein Kinase 2, Alpha 1 Polypeptide Pseudogene 2 3
  • CSNK2A1P 3 4
  • Casein Kinase II Alpha 1 Polypeptide Pseudogene 4
  • Casein Kinase 2, Alpha 1 Polypeptide-Like 3
  • CK II Alpha 3 4
  • EC 2.7.11.1 4

External Ids for CSNK2A3 Gene

Previous Symbols for CSNK2A3 Gene

  • CSNK2A1P

Summaries for CSNK2A3 Gene

Entrez Gene Summary for CSNK2A3 Gene

  • This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012]

GeneCards Summary for CSNK2A3 Gene

CSNK2A3 (Casein Kinase 2, Alpha 3 Polypeptide) is a Protein Coding gene. Diseases associated with CSNK2A3 include lung cancer. Among its related pathways are Wnt signaling pathway (KEGG) and TNF-alpha/NF-kB Signaling Pathway. An important paralog of this gene is CSNK2A2.

UniProtKB/Swiss-Prot for CSNK2A3 Gene

  • Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK2A3 Gene

Genomics for CSNK2A3 Gene

Genomic Location for CSNK2A3 Gene

Start:
11,351,942 bp from pter
End:
11,353,357 bp from pter
Size:
1,416 bases
Orientation:
Minus strand

Genomic View for CSNK2A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSNK2A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK2A3 Gene

No data available for Regulatory Elements for CSNK2A3 Gene

Proteins for CSNK2A3 Gene

  • Protein details for CSNK2A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEV1-CSK23_HUMAN
    Recommended name:
    Casein kinase II subunit alpha 3
    Protein Accession:
    Q8NEV1
    Secondary Accessions:

    Protein attributes for CSNK2A3 Gene

    Size:
    391 amino acids
    Molecular mass:
    45220 Da
    Quaternary structure:
    • Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha chain) and two regulatory subunits (beta chains) (By similarity). Interacts with PML.

neXtProt entry for CSNK2A3 Gene

Proteomics data for CSNK2A3 Gene at MOPED

Post-translational modifications for CSNK2A3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys83, Lys102, Lys122, and Lys303

Other Protein References for CSNK2A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CSNK2A3 Gene

Domains for CSNK2A3 Gene

UniProtKB/Swiss-Prot:

CSK23_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q8NEV1
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.:
    • Q8NEV1
genes like me logo Genes that share domains with CSNK2A3: view

No data available for Gene Families for CSNK2A3 Gene

Function for CSNK2A3 Gene

Molecular function for CSNK2A3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function: Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.

Enzyme Numbers (IUBMB) for CSNK2A3 Gene

Gene Ontology (GO) - Molecular Function for CSNK2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding --
GO:0005524 ATP binding --
genes like me logo Genes that share ontologies with CSNK2A3: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CSNK2A3 Gene

Localization for CSNK2A3 Gene

No data available for Gene Ontology (GO) - Cellular Components for CSNK2A3 Gene

Pathways for CSNK2A3 Gene

genes like me logo Genes that share pathways with CSNK2A3: view

Pathways by source for CSNK2A3 Gene

Interacting Proteins for CSNK2A3 Gene

Gene Ontology (GO) - Biological Process for CSNK2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0008284 positive regulation of cell proliferation --
GO:0030307 positive regulation of cell growth --
GO:0045732 positive regulation of protein catabolic process --
genes like me logo Genes that share ontologies with CSNK2A3: view

Transcripts for CSNK2A3 Gene

mRNA/cDNA for CSNK2A3 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK2A3 Gene

No ASD Table

Relevant External Links for CSNK2A3 Gene

GeneLoc Exon Structure for
CSNK2A3
ECgene alternative splicing isoforms for
CSNK2A3

Expression for CSNK2A3 Gene

mRNA expression in normal human tissues for CSNK2A3 Gene

SOURCE GeneReport for Unigene cluster for CSNK2A3 Gene Hs.654675

mRNA Expression by UniProt/SwissProt for CSNK2A3 Gene

Q8NEV1-CSK23_HUMAN
Tissue specificity: Detected in blood platelets and megakaryocyte cell lines. Poorly expressed in lung. Highly expressed in lung tumor tissues.
genes like me logo Genes that share expressions with CSNK2A3: view

Orthologs for CSNK2A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK2A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK2A3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSNK2A1 37
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Csnk2a1 37
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves CSNK2A1 37
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 95 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CU928126.3 37
  • 80 (a)
ManyToMany
zgc:86598 36
  • 76.84 (n)
  • 88.21 (a)
zgc:86598 37
  • 87 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CkIIalpha 37
  • 85 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-3 37
  • 77 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKA2 37
  • 57 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CKA1 36
  • 65.76 (n)
  • 73.03 (a)
rice
(Oryza sativa)
Liliopsida Os07g0114400 36
  • 67.07 (n)
  • 76.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11074 37
  • 85 (a)
OneToMany
Species with no ortholog for CSNK2A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CSNK2A3 Gene

ENSEMBL:
Gene Tree for CSNK2A3 (if available)
TreeFam:
Gene Tree for CSNK2A3 (if available)

Paralogs for CSNK2A3 Gene

Paralogs for CSNK2A3 Gene

genes like me logo Genes that share paralogs with CSNK2A3: view

Variants for CSNK2A3 Gene

Sequence variations from dbSNP and Humsavar for CSNK2A3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_069225 A lung carcinoma sample

Relevant External Links for CSNK2A3 Gene

HapMap Linkage Disequilibrium report
CSNK2A3
Human Gene Mutation Database (HGMD)
CSNK2A3

No data available for Structural Variations from Database of Genomic Variants (DGV) for CSNK2A3 Gene

Disorders for CSNK2A3 Gene

(1) MalaCards Diseases for CSNK2A3 Gene

Search for CSNK2A3 Gene in MalaCards »
genes like me logo Genes that share disorders with CSNK2A3: view

No data available for UniProtKB/Swiss-Prot for CSNK2A3 Gene

Publications for CSNK2A3 Gene

  1. Human casein kinase II subunit alpha: sequence of a processed (pseudo)gene and its localization on chromosome 11. (PMID: 1610905) Wirkner U. … Pyerin W. (Biochim. Biophys. Acta 1992) 2 3 4
  2. Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line. (PMID: 12102635) Singh L.S. … Kalafatis M. (Biochemistry 2002) 2 3 4
  3. Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. (PMID: 20625391) Hung M.S. … You L. (PLoS ONE 2010) 2 3 4
  4. Structure and sequence of an intronless gene for human casein kinase II-alpha subunit. (PMID: 8420794) Devilat I. … Carvallo P. (FEBS Lett. 1993) 3 4
  5. CK2alpha loci in the human genome: structure and transcriptional activity. (PMID: 10094393) Wirkner U. … Pyerin W. (Mol. Cell. Biochem. 1999) 3

Products for CSNK2A3 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate CSNK2A3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CSNK2A3
    • Block miRNA regulation of CSNK2A3 using miScript Target Protectors

    Sources for CSNK2A3 Gene

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