Aliases for CSNK2A3 Gene
Aliases for CSNK2A3 Gene
External Ids for CSNK2A3 Gene
- HGNC: 2458
- Entrez Gene: 283106
- Ensembl: ENSG00000254598
- UniProtKB: Q8NEV1
Previous HGNC Symbols for CSNK2A3 Gene
- CSNK2A1P
Summaries for CSNK2A3 Gene
-
This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012]
GeneCards Summary for CSNK2A3 Gene
CSNK2A3 (Casein Kinase 2 Alpha 3) is a Protein Coding gene. Among its related pathways are Mitophagy - animal and Influenza A. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK2A1.
UniProtKB/Swiss-Prot for CSNK2A3 Gene
-
Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK2A3 Gene
Genomics for CSNK2A3 Gene
Regulatory Elements for CSNK2A3 Gene
Enhancers for CSNK2A3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G010597 | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 12.7 | +755.5 | 755540 | 1.2 | ATF1 CEBPG IRF9 ELK1 ZNF584 RNF2 L3MBTL2 NR4A1 HLF CEBPB | CSNK2A3 MRVI1 ZBED5 RNF141 MRVI1-AS1 LYVE1 GC11M010566 |
| GH11G011391 | 1.1 | Ensembl ENCODE dbSUPER | 10.3 | -38.7 | -38671 | 1.1 | PKNOX1 JUN BHLHE40 ZMYM3 ZIC2 CTBP1 FOS KDM1A | ENSG00000255351 CSNK2A3 ENSG00000255462 PIR58328 |
| GH11G011426 | 1.1 | Ensembl ENCODE dbSUPER | 10.1 | -73.9 | -73929 | 2.1 | NFIC ZFHX2 POLR2A NFIB ZNF623 EGR2 | CSNK2A3 ENSG00000255351 USP47 PIR58328 |
| GH11G011313 | 0.9 | Ensembl ENCODE | 10.8 | +39.4 | 39362 | 1.9 | CTCF BHLHE40 MAFG ATF2 NR2F2 ZNF316 NFE2 FOS MAFK NFE2L2 | ENSG00000255351 CSNK2A3 GC11P011307 GC11M011353 |
| GH11G011462 | 0.9 | ENCODE | 10.6 | -110.2 | -110225 | 1.4 | PKNOX1 ARNT ZSCAN4 INSM2 KLF17 FEZF1 GLIS2 ZNF366 ZSCAN5C ZNF391 | ENSG00000255351 CSNK2A3 PIR58328 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CSNK2A3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CSNK2A3 Gene
- Chromosome:
- 11
- Start:
- 11,351,942 bp from pter
- End:
- 11,353,357 bp from pter
- Size:
- 1,416 bases
- Orientation:
- Minus strand
Genomic View for CSNK2A3 Gene
Genes around CSNK2A3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.4 by Ensembl
- 11p15.4 by Entrez Gene
- 11p15.4 by HGNC
CSNK2A3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CSNK2A3 Gene
Proteins for CSNK2A3 Gene
-
Protein details for CSNK2A3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NEV1-CSK23_HUMAN
- Recommended name:
- Casein kinase II subunit alpha 3
- Protein Accession:
- Q8NEV1
Protein attributes for CSNK2A3 Gene
- Size:
- 391 amino acids
- Molecular mass:
- 45220 Da
- Quaternary structure:
-
- Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha chain) and two regulatory subunits (beta chains) (By similarity). Interacts with PML.
Post-translational modifications for CSNK2A3 Gene
Other Protein References for CSNK2A3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CSNK2A3
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- Search GeneTex for Proteins for CSNK2A3
Assay Products
No data available for DME Specific Peptides for CSNK2A3 Gene
Domains & Families for CSNK2A3 Gene
Protein Domains for CSNK2A3 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
Q8NEV1UniProtKB/Swiss-Prot:
CSK23_HUMAN :- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
No data available for Gene Families and Suggested Antigen Peptide Sequences for CSNK2A3 Gene
Function for CSNK2A3 Gene
Molecular function for CSNK2A3 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.
Enzyme Numbers (IUBMB) for CSNK2A3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for CSNK2A3 Gene
- GenomeRNAi human phenotypes for CSNK2A3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CSNK2A3
-
- Search ViGene Biosciences for CSNK2A3
CRISPR Products
- Browse CRISPR knockouts for CSNK2A3
- GenScript: Design CRISPR guide RNA sequences for CSNK2A3
miRNA Products
- Search ViGene Biosciences for CSNK2A3
Inhibitory RNA Products
- Search ViGene Biosciences for CSNK2A3
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CSNK2A3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK2A3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CSNK2A3 Gene
Localization for CSNK2A3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CSNK2A3 Gene
Pathways & Interactions for CSNK2A3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Influenza A |
.34
|
|
| 2 | Adherens junction | ||
| 3 | Epstein-Barr virus infection | ||
| 4 | Mitophagy - animal | ||
| 5 | NF-kappa B signaling pathway | ||
Pathways by source for CSNK2A3 Gene
8 KEGG pathways for CSNK2A3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IDA | -- |
| GO:0008284 | positive regulation of cell proliferation | IDA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0030307 | positive regulation of cell growth | IDA | -- |
| GO:0045732 | positive regulation of protein catabolic process | IDA | -- |
No data available for SIGNOR curated interactions for CSNK2A3 Gene
Drugs & Compounds for CSNK2A3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cisplatin | Approved | Pharma | Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 | 2770 | ||
| Ellagic acid | Investigational | Pharma | Casein kinase 2 (CK2) inhibitor, Selective inhibitor of CK2. Also inhibits glutathione S-transferase | 0 | ||
| CX-4945 (Silmitasertib) | Pharma | CK2 inhibitor | 0 | |||
| TTP 22 | Pharma | CK2 inhibitor, High affinity, selective CK2 inhibitor | 0 |
(3) ApexBio Compounds for CSNK2A3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CX-4945 (Silmitasertib) | CK2 inhibitor | 1009820-21-6 |
| Ellagic acid | Casein kinase 2 (CK2) inhibitor | 476-66-4 |
| TTP 22 | CK2 inhibitor | 329907-28-0 |
Drug Products
- ApexBio compounds for CSNK2A3
Transcripts for CSNK2A3 Gene
mRNA/cDNA for CSNK2A3 Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for CSNK2A3
- GenScript: Design CRISPR guide RNA sequences for CSNK2A3
miRNA Products
- Search ViGene Biosciences for CSNK2A3
Inhibitory RNA Products
- Search ViGene Biosciences for CSNK2A3
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CSNK2A3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK2A3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CSNK2A3 Gene
NURSA nuclear receptor signaling pathways regulating expression of CSNK2A3 Gene:
CSNK2A3SOURCE GeneReport for Unigene cluster for CSNK2A3 Gene:
Hs.654675mRNA Expression by UniProt/SwissProt for CSNK2A3 Gene:
Q8NEV1-CSK23_HUMAN
Tissue specificity:
Detected in blood platelets and megakaryocyte cell lines. Poorly expressed in lung. Highly expressed in lung tumor tissues.
Primer Products
-
OriGene qPCR primer pairs for CSNK2A3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK2A3 Gene
Orthologs for CSNK2A3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CSNK2A3 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Csnk2a1 35 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | CSNK2A1 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CSNK2A1 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | CU928126.3 35 |
|
ManyToMany | |
| zgc:86598 34 35 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CkIIalpha 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | kin-3 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CKA2 35 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | CKA1 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0114400 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11074 35 |
|
OneToMany |
- Species where no ortholog for CSNK2A3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for CSNK2A3 Gene
(32) SIMAP similar genes for CSNK2A3 Gene using alignment to 1 proteins:
Variants for CSNK2A3 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2071460 | A lung carcinoma sample | 11,352,722(-) | TGATA(C/T)TCGAT | intron-variant, downstream-variant-500B, reference, missense | |
| rs1000624108 | -- | 11,354,263(+) | CTGAA(A/G)GGAAC | intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime | |
| rs1000655481 | -- | 11,354,624(+) | CCTAA(A/G)TATCA | intron-variant, upstream-variant-2KB, utr-variant-3-prime | |
| rs1002060430 | -- | 11,354,648(+) | TCACT(A/G)TAATA | intron-variant, upstream-variant-2KB, utr-variant-3-prime | |
| rs1002346731 | -- | 11,355,174(+) | CTTTA(A/G)TGCAG | intron-variant, upstream-variant-2KB, utr-variant-3-prime |
Residual Variation Intolerance Score:
97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.78;
93.37% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CSNK2A3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK2A3 Gene
Disorders for CSNK2A3 Gene
Relevant External Links for CSNK2A3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CSNK2A3
No disorders were found for CSNK2A3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK2A3 Gene
Publications for CSNK2A3 Gene
- Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. (PMID: 20625391) Hung M.S. … You L. (PLoS ONE 2010) 2 3 4 64
- Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line. (PMID: 12102635) Singh L.S. … Kalafatis M. (Biochemistry 2002) 2 3 4 64
- Human casein kinase II subunit alpha: sequence of a processed (pseudo)gene and its localization on chromosome 11. (PMID: 1610905) Wirkner U. … Pyerin W. (Biochim. Biophys. Acta 1992) 2 3 4 64
- Structure and sequence of an intronless gene for human casein kinase II-alpha subunit. (PMID: 8420794) Devilat I. … Carvallo P. (FEBS Lett. 1993) 3 4 64
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
Products for CSNK2A3 Gene
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- VectorBuilder custom plasmid, inducible vectors for CSNK2A3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK2A3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CSNK2A3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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- (24) DrugBank
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- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
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- (62) NCBI
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- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
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- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
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