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Aliases for CSNK2A2 Gene

Aliases for CSNK2A2 Gene

  • Casein Kinase 2 Alpha 2 2 3
  • Casein Kinase 2, Alpha Prime Polypeptide 2 3 5
  • Casein Kinase 2 Alpha 2 3
  • CK II Alpha 3 4
  • EC 2.7.11.1 4 63
  • CK2A2 3 4
  • EC 2.7.11 63
  • CK2alpha 3
  • CSNK2A1 3

External Ids for CSNK2A2 Gene

Previous GeneCards Identifiers for CSNK2A2 Gene

  • GC16M048586
  • GC16M058275
  • GC16M057926
  • GC16M057967
  • GC16M056749
  • GC16M044059

Summaries for CSNK2A2 Gene

GeneCards Summary for CSNK2A2 Gene

CSNK2A2 (Casein Kinase 2 Alpha 2) is a Protein Coding gene. Diseases associated with CSNK2A2 include spermatogenic failure 6 and theileriasis. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK2A1.

UniProtKB/Swiss-Prot for CSNK2A2 Gene

  • Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating Ser-392 of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.

Tocris Summary for CSNK2A2 Gene

  • Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase thought to have a regulatory function in cell proliferation, differentiation and apoptosis. CK2 functions as a tetrameric complex with 2 regulatory and 2 catalytic subunits.

Gene Wiki entry for CSNK2A2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK2A2 Gene

Genomics for CSNK2A2 Gene

Regulatory Elements for CSNK2A2 Gene

Promoters for CSNK2A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CSNK2A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CSNK2A2 Gene

Chromosome:
16
Start:
58,157,907 bp from pter
End:
58,197,920 bp from pter
Size:
40,014 bases
Orientation:
Minus strand

Genomic View for CSNK2A2 Gene

Genes around CSNK2A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK2A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK2A2 Gene

Proteins for CSNK2A2 Gene

  • Protein details for CSNK2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19784-CSK22_HUMAN
    Recommended name:
    Casein kinase II subunit alpha
    Protein Accession:
    P19784

    Protein attributes for CSNK2A2 Gene

    Size:
    350 amino acids
    Molecular mass:
    41213 Da
    Quaternary structure:
    • Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha/2 beta or 1 alpha/1 alpha/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation. Interacts with RNPS1.
    Miscellaneous:
    • Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome.

    Three dimensional structures from OCA and Proteopedia for CSNK2A2 Gene

neXtProt entry for CSNK2A2 Gene

Proteomics data for CSNK2A2 Gene at MOPED

Post-translational modifications for CSNK2A2 Gene

  • Ubiquitination at Lys 304
  • Modification sites at PhosphoSitePlus

Other Protein References for CSNK2A2 Gene

Domains & Families for CSNK2A2 Gene

Suggested Antigen Peptide Sequences for CSNK2A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19784

UniProtKB/Swiss-Prot:

CSK22_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
genes like me logo Genes that share domains with CSNK2A2: view

Function for CSNK2A2 Gene

Molecular function for CSNK2A2 Gene

GENATLAS Biochemistry:
casein kinase II,catalytic unit,alpha 2,likely involved in regulation of cell growth,ubiquitous
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization (By similarity).
UniProtKB/Swiss-Prot Function:
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating Ser-392 of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.

Enzyme Numbers (IUBMB) for CSNK2A2 Gene

Gene Ontology (GO) - Molecular Function for CSNK2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0047485 protein N-terminus binding IPI 11972058
genes like me logo Genes that share ontologies with CSNK2A2: view
genes like me logo Genes that share phenotypes with CSNK2A2: view

Animal Models for CSNK2A2 Gene

MGI Knock Outs for CSNK2A2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CSNK2A2

miRNA for CSNK2A2 Gene

miRTarBase miRNAs that target CSNK2A2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK2A2 Gene

Localization for CSNK2A2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK2A2 Gene COMPARTMENTS Subcellular localization image for CSNK2A2 gene
Compartment Confidence
cytosol 5
nucleus 5

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CSNK2A2 Gene

Pathways & Interactions for CSNK2A2 Gene

genes like me logo Genes that share pathways with CSNK2A2: view

SIGNOR curated interactions for CSNK2A2 Gene

Activates:
Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for CSNK2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process IEA --
GO:0007411 axon guidance TAS --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CSNK2A2: view

Drugs & Compounds for CSNK2A2 Gene

(51) Drugs for CSNK2A2 Gene - From: Novoseek, HMDB, ApexBio, Tocris, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Experimental Pharma Target 0
Ellagic acid Investigational Pharma Casein kinase 2 (CK2) inhibitor, Selective inhibitor of CK2. Also inhibits glutathione S-transferase 0
TTP 22 Pharma CK2 inhibitor, High affinity, selective CK2 inhibitor 0
CX-4945 (Silmitasertib) Pharma CK2 inhibitor 0

(32) Additional Compounds for CSNK2A2 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
TBB
17374-26-4
TBCA
934358-00-6
TMCB
905105-89-7
genes like me logo Genes that share compounds with CSNK2A2: view

Transcripts for CSNK2A2 Gene

Unigene Clusters for CSNK2A2 Gene

Casein kinase 2, alpha prime polypeptide:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK2A2 Gene

No ASD Table

Relevant External Links for CSNK2A2 Gene

GeneLoc Exon Structure for
CSNK2A2
ECgene alternative splicing isoforms for
CSNK2A2

Expression for CSNK2A2 Gene

mRNA expression in normal human tissues for CSNK2A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSNK2A2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSNK2A2 Gene



SOURCE GeneReport for Unigene cluster for CSNK2A2 Gene Hs.82201

genes like me logo Genes that share expression patterns with CSNK2A2: view

Protein tissue co-expression partners for CSNK2A2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSNK2A2 Gene

Orthologs for CSNK2A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK2A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK2A2 36
  • 100 (a)
OneToOne
CSNK2A2 35
  • 99.58 (n)
  • 99.37 (a)
cow
(Bos Taurus)
Mammalia CSNK2A2 36
  • 99 (a)
OneToOne
CSNK2A2 35
  • 95.52 (n)
  • 99.14 (a)
dog
(Canis familiaris)
Mammalia CSNK2A2 35
  • 95.68 (n)
  • 99.37 (a)
CSNK2A2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csnk2a2 36
  • 99 (a)
OneToOne
Csnk2a2 16
Csnk2a2 35
  • 94.86 (n)
  • 98.86 (a)
oppossum
(Monodelphis domestica)
Mammalia CSNK2A2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSNK2A2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csnk2a2 35
  • 94.38 (n)
  • 98.29 (a)
chicken
(Gallus gallus)
Aves CSNK2A2 35
  • 86.57 (n)
  • 97.14 (a)
CSNK2A2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSNK2A2 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2127 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6473 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5116 35
zebrafish
(Danio rerio)
Actinopterygii ck2a2a 36
  • 81 (a)
OneToMany
ck2a2b 36
  • 85 (a)
OneToMany
ck2a2 35
ck2a2b 35
  • 76.1 (n)
  • 85.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CkIIalpha 37
  • 81 (a)
worm
(Caenorhabditis elegans)
Secernentea B0205.7 37
  • 79 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL102C 35
  • 60.21 (n)
  • 63.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKA1 35
  • 62.29 (n)
  • 66.87 (a)
CKA2 36
  • 56 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E04247g 35
  • 61.04 (n)
  • 61.87 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10019 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G23080 35
  • 67.38 (n)
  • 71.78 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3941 35
corn
(Zea mays)
Liliopsida Zm.569 35
rice
(Oryza sativa)
Liliopsida Os.1955 35
Os03g0207300 35
  • 69.16 (n)
  • 73.52 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.181 35
Species with no ortholog for CSNK2A2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CSNK2A2 Gene

ENSEMBL:
Gene Tree for CSNK2A2 (if available)
TreeFam:
Gene Tree for CSNK2A2 (if available)

Paralogs for CSNK2A2 Gene

Paralogs for CSNK2A2 Gene

(15) SIMAP similar genes for CSNK2A2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CSNK2A2: view

Variants for CSNK2A2 Gene

Sequence variations from dbSNP and Humsavar for CSNK2A2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs55911801 - 58,167,746(+) TGTAC(G/T)CCTGA reference, missense
rs37360 -- 58,164,911(+) TTTCC(A/C)TCTTG intron-variant
rs37361 -- 58,165,005(+) CACAC(A/G)TTATC intron-variant
rs37362 -- 58,165,013(+) ATCAG(A/T)GGAAA intron-variant
rs37363 -- 58,165,052(+) AACAC(A/G)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK2A2 Gene

Variant ID Type Subtype PubMed ID
nsv819431 CNV Loss 19587683
esv2659878 CNV Deletion 23128226
esv2665560 CNV Deletion 23128226
nsv457491 CNV Loss 19166990
esv23104 CNV Loss 19812545

Variation tolerance for CSNK2A2 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK2A2 Gene

HapMap Linkage Disequilibrium report
CSNK2A2
Human Gene Mutation Database (HGMD)
CSNK2A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK2A2 Gene

Disorders for CSNK2A2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CSNK2A2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
spermatogenic failure 6
  • spermatogenic failure 9
theileriasis
  • infection by theileria
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CSNK2A2

Genetic Association Database (GAD)
CSNK2A2
Human Genome Epidemiology (HuGE) Navigator
CSNK2A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK2A2
genes like me logo Genes that share disorders with CSNK2A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSNK2A2 Gene

Publications for CSNK2A2 Gene

  1. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. (PMID: 2174700) Lozeman F.J. … Krebs E.G. (Biochemistry 1990) 2 3 4 23 67
  2. Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. (PMID: 10806215) Song D.H. … Seldin D.C. (J. Biol. Chem. 2000) 3 23
  3. Phosphorylation of AZT-resistant human immunodeficiency virus type 1 reverse transcriptase by casein kinase II in vitro: effects on inhibitor sensitivity. (PMID: 10944435) Lazaro J.B. … Canard B. (Biochem. Biophys. Res. Commun. 2000) 3 23
  4. Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5. (PMID: 9858576) Kasahara H. … Izumo S. (Mol. Cell. Biol. 1999) 3 23
  5. Differential phosphorylation of syntaxin and synaptosome-associated protein of 25 kDa (SNAP-25) isoforms. (PMID: 9930733) Risinger C. … Bennett M.K. (J. Neurochem. 1999) 3 23

Products for CSNK2A2 Gene

Sources for CSNK2A2 Gene

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