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Aliases for CSNK2A2 Gene

Aliases for CSNK2A2 Gene

  • Casein Kinase 2, Alpha Prime Polypeptide 2 3
  • CK II Alpha 3 4
  • EC 2.7.11.1 4 63
  • CK2A2 3 4
  • Casein Kinase II Subunit Alpha 3
  • EC 2.7.11 63
  • CSNK2A1 3

External Ids for CSNK2A2 Gene

Previous GeneCards Identifiers for CSNK2A2 Gene

  • GC16M048586
  • GC16M058275
  • GC16M057926
  • GC16M057967
  • GC16M056749
  • GC16M044059

Summaries for CSNK2A2 Gene

GeneCards Summary for CSNK2A2 Gene

CSNK2A2 (Casein Kinase 2, Alpha Prime Polypeptide) is a Protein Coding gene. Diseases associated with CSNK2A2 include theileriasis and pandas. Among its related pathways are L1CAM interactions and NF-KappaB Family Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein N-terminus binding. An important paralog of this gene is CSNK2A1.

UniProtKB/Swiss-Prot for CSNK2A2 Gene

  • Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating Ser-392 of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.

Tocris Summary for CSNK2A2 Gene

  • Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.

Gene Wiki entry for CSNK2A2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK2A2 Gene

Genomics for CSNK2A2 Gene

Regulatory Elements for CSNK2A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CSNK2A2 Gene

Start:
58,157,907 bp from pter
End:
58,197,920 bp from pter
Size:
40,014 bases
Orientation:
Minus strand

Genomic View for CSNK2A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSNK2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK2A2 Gene

Proteins for CSNK2A2 Gene

  • Protein details for CSNK2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19784-CSK22_HUMAN
    Recommended name:
    Casein kinase II subunit alpha
    Protein Accession:
    P19784
    Secondary Accessions:

    Protein attributes for CSNK2A2 Gene

    Size:
    350 amino acids
    Molecular mass:
    41213 Da
    Quaternary structure:
    • Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha/2 beta or 1 alpha/1 alpha/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation. Interacts with RNPS1.
    Miscellaneous:
    • Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome

    Three dimensional structures from OCA and Proteopedia for CSNK2A2 Gene

neXtProt entry for CSNK2A2 Gene

Proteomics data for CSNK2A2 Gene at MOPED

Post-translational modifications for CSNK2A2 Gene

  • Ubiquitination at Lys304
  • Modification sites at PhosphoSitePlus

Other Protein References for CSNK2A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CSNK2A2 Gene

Suggested Antigen Peptide Sequences for CSNK2A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19784

UniProtKB/Swiss-Prot:

CSK22_HUMAN :
  • P19784
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
genes like me logo Genes that share domains with CSNK2A2: view

Function for CSNK2A2 Gene

Molecular function for CSNK2A2 Gene

GENATLAS Biochemistry:
casein kinase II,catalytic unit,alpha 2,likely involved in regulation of cell growth,ubiquitous
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization (By similarity).
UniProtKB/Swiss-Prot Function:
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating Ser-392 of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.

Enzyme Numbers (IUBMB) for CSNK2A2 Gene

Gene Ontology (GO) - Molecular Function for CSNK2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 10094392
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CSNK2A2: view
genes like me logo Genes that share phenotypes with CSNK2A2: view

Animal Models for CSNK2A2 Gene

MGI Knock Outs for CSNK2A2:

Animal Model Products

miRNA for CSNK2A2 Gene

miRTarBase miRNAs that target CSNK2A2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSNK2A2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CSNK2A2 Gene

Localization for CSNK2A2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK2A2 Gene COMPARTMENTS Subcellular localization image for CSNK2A2 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CSNK2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21282530
GO:0005829 cytosol TAS --
GO:0031519 colocalizes_with PcG protein complex IDA 21282530
genes like me logo Genes that share ontologies with CSNK2A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CSNK2A2 Gene

Pathways for CSNK2A2 Gene

genes like me logo Genes that share pathways with CSNK2A2: view

Pathways by source for CSNK2A2 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for CSNK2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with CSNK2A2: view

Compounds for CSNK2A2 Gene

(4) Tocris Compounds for CSNK2A2 Gene

Compound Action Cas Number
Ellagic acid Selective inhibitor of CK2. Also inhibits glutathione S-transferase [476-66-4]
TBB Selective cell-permeable CK2 inhibitor [17374-26-4]
TMCB Dual-kinase inhibitor; inhibits CK2 and ERK8 [905105-89-7]
TTP 22 High affinity, selective CK2 inhibitor [329907-28-0]

(3) ApexBio Compounds for CSNK2A2 Gene

Compound Action Cas Number
CX-4945 (Silmitasertib) CK2 inhibitor [1009820-21-6]
Ellagic acid Casein kinase 2 (CK2) inhibitor [476-66-4]
TTP 22 CK2 inhibitor [329907-28-0]

(2) HMDB Compounds for CSNK2A2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(1) Drugbank Compounds for CSNK2A2 Gene

(74) Novoseek inferred chemical compound relationships for CSNK2A2 Gene

Compound -log(P) Hits PubMed IDs
5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 78 7
serine 77.1 58
threonine 74.4 37
phosphoserine 66.4 7
5,6-dichlorobenzimidazole riboside 64.7 3
genes like me logo Genes that share compounds with CSNK2A2: view

Transcripts for CSNK2A2 Gene

Unigene Clusters for CSNK2A2 Gene

Casein kinase 2, alpha prime polypeptide:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSNK2A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK2A2 Gene

No ASD Table

Relevant External Links for CSNK2A2 Gene

GeneLoc Exon Structure for
CSNK2A2
ECgene alternative splicing isoforms for
CSNK2A2

Expression for CSNK2A2 Gene

mRNA expression in normal human tissues for CSNK2A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CSNK2A2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSNK2A2 Gene

SOURCE GeneReport for Unigene cluster for CSNK2A2 Gene Hs.82201

genes like me logo Genes that share expressions with CSNK2A2: view

Expression partners for CSNK2A2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSNK2A2 Gene

Orthologs for CSNK2A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK2A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSNK2A2 35
  • 95.52 (n)
  • 99.14 (a)
CSNK2A2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSNK2A2 35
  • 95.68 (n)
  • 99.37 (a)
CSNK2A2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csnk2a2 35
  • 94.86 (n)
  • 98.86 (a)
Csnk2a2 16
Csnk2a2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSNK2A2 35
  • 99.58 (n)
  • 99.37 (a)
CSNK2A2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csnk2a2 35
  • 94.38 (n)
  • 98.29 (a)
oppossum
(Monodelphis domestica)
Mammalia CSNK2A2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSNK2A2 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves CSNK2A2 35
  • 86.57 (n)
  • 97.14 (a)
CSNK2A2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSNK2A2 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6473 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2127 35
zebrafish
(Danio rerio)
Actinopterygii ck2a2 35
ck2a2b 35
  • 76.1 (n)
  • 85.71 (a)
ck2a2a 36
  • 81 (a)
OneToMany
ck2a2b 36
  • 85 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5116 35
fruit fly
(Drosophila melanogaster)
Insecta CkIIalpha 37
  • 81 (a)
worm
(Caenorhabditis elegans)
Secernentea B0205.7 37
  • 79 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL102C 35
  • 60.21 (n)
  • 63.12 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E04247g 35
  • 61.04 (n)
  • 61.87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKA1 35
  • 62.29 (n)
  • 66.87 (a)
CKA2 36
  • 56 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G23080 35
  • 67.38 (n)
  • 71.78 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10019 35
barley
(Hordeum vulgare)
Liliopsida Hv.3941 35
rice
(Oryza sativa)
Liliopsida Os.1955 35
Os03g0207300 35
  • 69.16 (n)
  • 73.52 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.181 35
corn
(Zea mays)
Liliopsida Zm.569 35
Species with no ortholog for CSNK2A2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CSNK2A2 Gene

ENSEMBL:
Gene Tree for CSNK2A2 (if available)
TreeFam:
Gene Tree for CSNK2A2 (if available)

Paralogs for CSNK2A2 Gene

Paralogs for CSNK2A2 Gene

Selected SIMAP similar genes for CSNK2A2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CSNK2A2: view

Variants for CSNK2A2 Gene

Sequence variations from dbSNP and Humsavar for CSNK2A2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs37359 -- 58,164,904(+) GTGAA(C/T)GTTTC intron-variant
rs37360 -- 58,164,911(+) TTTCC(A/C)TCTTG intron-variant
rs37361 -- 58,165,005(+) CACAC(A/G)TTATC intron-variant
rs37362 -- 58,165,013(+) ATCAG(A/T)GGAAA intron-variant
rs37363 -- 58,165,052(+) AACAC(A/G)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK2A2 Gene

Variant ID Type Subtype PubMed ID
nsv819431 CNV Loss 19587683
esv2659878 CNV Deletion 23128226
esv2665560 CNV Deletion 23128226
nsv457491 CNV Loss 19166990
esv23104 CNV Loss 19812545

Relevant External Links for CSNK2A2 Gene

HapMap Linkage Disequilibrium report
CSNK2A2
Human Gene Mutation Database (HGMD)
CSNK2A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK2A2 Gene

Disorders for CSNK2A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CSNK2A2 Gene in MalaCards »

(2) Diseases for CSNK2A2 Gene including...

(1) University of Copenhagen DISEASES for CSNK2A2 Gene

(24) Novoseek inferred disease relationships for CSNK2A2 Gene

Disease -log(P) Hits PubMed IDs
globozoospermia 59.3 5
theileriosis 31.5 2
retinoblastoma 20.3 1
paired helical filament 12.9 1
astrocytoma 0 1

Relevant External Links for CSNK2A2

Genetic Association Database (GAD)
CSNK2A2
Human Genome Epidemiology (HuGE) Navigator
CSNK2A2
genes like me logo Genes that share disorders with CSNK2A2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CSNK2A2 Gene

Publications for CSNK2A2 Gene

  1. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. (PMID: 2174700) Lozeman F.J. … Krebs E.G. (Biochemistry 1990) 2 3 4 23
  2. Interaction between casein kinase II and the 90-kDa stress protein, HSP90. (PMID: 7794926) Miyata Y. … Yahara I. (Biochemistry 1995) 3 23
  3. Human-immunodeficiency-virus-type-1-encoded Vpu protein is phosphorylated by casein kinase II. (PMID: 1541298) Schubert U. … Porstmann T. (Eur. J. Biochem. 1992) 3 23
  4. Phosphorylation of cardiac and skeletal muscle calsequestrin isoforms by casein kinase II. Demonstration of a cluster of unique rapidly phosphorylated sites in cardiac calsequestrin. (PMID: 1985907) Cala S.E. … Jones L.R. (J. Biol. Chem. 1991) 3 23
  5. The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin. (PMID: 7689229) Jin Y.J. … Burakoff S.J. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 23

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