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CSNK2A2 Gene

protein-coding   GIFtS: 74
GCID: GC16M058191

Casein Kinase 2, Alpha Prime Polypeptide

  See CSNK2A2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Casein Kinase 2, Alpha Prime Polypeptide1 2     CSNK2A12
CK2A22 3     Casein Kinase II Subunit Alpha'2
CK II Alpha'2 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 24591   Entrez Gene: 14592   Ensembl: ENSG000000707707   OMIM: 1154425   UniProtKB: P197843   

Export aliases for CSNK2A2 gene to outside databases

Previous GC identifers: GC16M048586 GC16M058275 GC16M057926 GC16M057967 GC16M056749 GC16M044059


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CSNK2A2 Gene:
CSNK2A2 (casein kinase 2, alpha prime polypeptide) is a protein-coding gene. Diseases associated with CSNK2A2 include theileriasis, and globozoospermia. GO annotations related to this gene include protein serine/threonine kinase activity and protein N-terminus binding. An important paralog of this gene is CSNK2A1.

UniProtKB/Swiss-Prot: CSK22_HUMAN, P19784
Function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates
a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as
viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an
appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle
assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also
required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can
also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3.
Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and
activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also
phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1,
SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential
for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts
as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates
various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV

summary for CSNK2A2 Gene:
Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase
that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2
functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha
and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are
catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the
alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins
implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought
to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the
phosphorylation of Akt.

Gene Wiki entry for CSNK2A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSNK2A2 gene promoter:
         TBP   CREB   PPAR-gamma1   deltaCREB   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSNK2A2 promoter sequence
   Search Chromatin IP Primers for CSNK2A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSNK2A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q21

CSNK2A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK2A2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M058191:  view genomic region     (about GC identifiers)

Start:
58,191,811 bp from pter      End:
58,231,824 bp from pter
Size:
40,014 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CSK22_HUMAN, P19784 (See protein sequence)
Recommended Name: Casein kinase II subunit alpha'  
Size: 350 amino acids; 41213 Da
Subunit: Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory
subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha'/2 beta or 1 alpha/1
alpha'/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and
CSNK2B, which forms following UV irradiation. Interacts with RNPS1
Miscellaneous: Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been
estimated to represent up to one quarter of the eukaryotic phosphoproteome
3 PDB 3D structures from and Proteopedia for CSNK2A2:
3E3B (3D)        3OFM (3D)        3U87 (3D)    

Explore the universe of human proteins at neXtProt for CSNK2A2: NX_P19784

Explore proteomics data for CSNK2A2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys304
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CSNK2A2 (P19784) (see all 21)
     REYWDYE  EVFEAIN  DNYDQLV  IAKVLGT 


    See CSNK2A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001887.1  
    ENSEMBL proteins: 
     ENSP00000262506   ENSP00000456606   ENSP00000457911   ENSP00000454874  
    Reactome Protein details: P19784

    CSNK2A2 Human Recombinant Protein Products:

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    antibodies-online proteins for CSNK2A2 (5 products) 

     
    antibodies-online peptides for CSNK2A2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: casein kinase 2, alpha prime polypeptide subunit
    Selected non-AGC protein kinase activities
    Casein kinase 2 (CK2) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P19784

    ProtoNet protein and cluster: P19784

    UniProtKB/Swiss-Prot: CSK22_HUMAN, P19784
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CSNK2A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSK22_HUMAN, P19784
    Function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates
    a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
    Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as
    viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an
    appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle
    assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also
    required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can
    also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3.
    Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and
    activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also
    phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1,
    SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential
    for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts
    as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates
    various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Constitutively active protein kinase whose activity is not directly affected by
    phosphorylation. Seems to be regulated by level of expression and localization (By similarity)

         Genatlas biochemistry entry for CSNK2A2:
    casein kinase II,catalytic unit,alpha 2,likely involved in regulation of cell growth,ubiquitous

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10094392
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CSNK2A2           About GenesLikeMe


    Phenotypes:
         8 GenomeRNAi human phenotypes for CSNK2A2:
     Decreased cell number  Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability 
     Decreased viability of wild-ty  G0/1 arrest  Increased gamma-H2AX phosphory  Weaker migration 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Csnk2a2):
     cellular  reproductive system 

    Find genes that share phenotypes with CSNK2A2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Csnk2a2tm1Dcs for CSNK2A2

       genOway: Develop your customized and physiologically relevant rodent model for CSNK2A2

    miRNA
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    miRTarBase miRNAs that target CSNK2A2:
    hsa-mir-1 (MIRT024100)

    Block miRNA regulation of human, mouse, rat CSNK2A2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSNK2A2 (see all 10):
    hsa-miR-767-3p hsa-miR-3688-3p hsa-miR-130a* hsa-miR-23c hsa-miR-421 hsa-miR-659 hsa-miR-208a hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidCSNK2A2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005829cytosol TAS--
    GO:0031519colocalizes with PcG protein complex IDA--

    Find genes that share ontologies with CSNK2A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSNK2A2 About   (see all 21)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    4Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Condensation of Prometaphase Chromosomes0.00
    5Translation Insulin regulation of translation
    Translation Regulation activity of EIF20.47
    Cell adhesion PLAU signaling0.35


    Find genes that share SuperPaths with CSNK2A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CSNK2A2
        Notch Signaling Pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CSNK2A2
        NF-KappaB (p50-p65) Pathway
    GSK3 Signaling
    Erythropoietin Pathway

    1 Tocris Bioscience Pathway for CSNK2A2
        NF-kappaB Pathway

    4 GeneGo (Thomson Reuters) Pathways for CSNK2A2
        Cell adhesion PLAU signaling
    DNA damage NHEJ mechanisms of DSBs repair
    Translation Regulation of EIF2 activity
    Regulation of CFTR activity (norm and CF)

    2 BioSystems Pathways for CSNK2A2
        Wnt Signaling Pathway NetPath
    TNF-alpha/NF-kB Signaling Pathway

    1 Sino Biological Pathway for CSNK2A2
        Non-Canonical Wnt Pathway

    3 Reactome Pathways for CSNK2A2
        Signal transduction by L1
    WNT mediated activation of DVL
    Condensation of Prometaphase Chromosomes


    Selected Kegg Pathways  (Kegg details for CSNK2A2) (see all 8):
        Ribosome biogenesis in eukaryotes
    NF-kappa B signaling pathway
    Wnt signaling pathway
    Adherens junction
    Tight junction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSNK2A2 (see all 6): 
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CSNK2A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSNK2A2 (P197841, 2, 3 ENSP000002625064) via UniProtKB, MINT, STRING, and/or I2D (see all 317)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206406P678701, 2, 3EBI-347451,EBI-348169 MINT-62609 MINT-62783 MINT-62707 I2D: score=6 
    ENSG00000224398P678701, 2, 3EBI-347451,EBI-348169 MINT-62609 MINT-62783 MINT-62707 I2D: score=6 
    ENSG00000228875P678701, 2, 3EBI-347451,EBI-348169 MINT-62609 MINT-62783 MINT-62707 I2D: score=6 
    ENSG00000230700P678701, 2, 3EBI-347451,EBI-348169 MINT-62609 MINT-62783 MINT-62707 I2D: score=6 
    ENSG00000224774P678701, 2, 3, ENSP000004156154EBI-347451,EBI-348169 MINT-62609 MINT-62783 MINT-62707 I2D: score=6 STRING: ENSP00000415615
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process IEA--

    Find genes that share ontologies with CSNK2A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Compounds for CSNK2A2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TMCBDual-kinase inhibitor; inhibits CK2 and ERK8[905105-89-7]
    TBBSelective cell-permeable CK2 inhibitor[17374-26-4]
    TTP 22 High affinity, selective CK2 inhibitor [329907-28-0]
    Ellagic acidSelective inhibitor of CK2. Also inhibits glutathione S-transferase[476-66-4]

    2 HMDB Compounds for CSNK2A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for CSNK2A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    [1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for CSNK2A2 gene (see all 74)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 78 8 18556661 (1), 20026644 (1), 11593402 (1), 16901965 (1) (see all 7)
    serine 77.1 58 10329715 (2), 9834084 (2), 1939094 (1), 7697130 (1) (see all 56)
    threonine 74.4 37 8157958 (1), 7518565 (1), 8943850 (1), 2171517 (1) (see all 37)
    phosphoserine 66.4 11 2171517 (2), 14594814 (1), 8427963 (1), 1445320 (1) (see all 6)
    5,6-dichlorobenzimidazole riboside 64.7 3 18404524 (1), 7683660 (1), 8765099 (1)
    orthophosphate 58.2 5 2300566 (3), 10612431 (1), 7838153 (1)
    gtp 54.9 9 8768785 (2), 8049218 (1), 10398759 (1), 8867814 (1) (see all 8)
    okadaic acid 50.5 3 8356082 (1), 16901965 (1), 17088080 (1)
    phosphothreonine 49.9 3 8427963 (1), 2307228 (1)
    atp 47.5 14 8768785 (3), 9630925 (2), 8383533 (2), 10398759 (1) (see all 9)



    Find genes that share compounds with CSNK2A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CSNK2A2 gene: 
    NM_001896.2  

    Unigene Cluster for CSNK2A2:

    Casein kinase 2, alpha prime polypeptide
    Hs.82201  [show with all ESTs]
    Unigene Representative Sequence: AK125922
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566813 ENST00000262506(uc002enc.3) ENST00000567730 ENST00000563307
    ENST00000562367 ENST00000565188
    miRNA
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    hsa-miR-767-3p hsa-miR-3688-3p hsa-miR-130a* hsa-miR-23c hsa-miR-421 hsa-miR-659 hsa-miR-208a hsa-miR-208b
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    Additional mRNA sequence: 

    AK090752.1 AK125922.1 BC008812.2 BC053935.1 M55268.1 

    6 DOTS entries:

    DT.454203  DT.75158116  DT.315256  DT.120687609  DT.100043316  DT.426283 

    Selected AceView cDNA sequences (see all 333):

    AW515251 BU167844 N27700 BF675095 NM_001896 BM828117 AA121924 BM849397 
    CB123078 BU172686 BQ012319 AW503051 BQ020759 AA843669 BM838161 AI420178 
    BU151193 AI419061 AA532455 BX089147 AW269697 BU158536 BM699334 AW952074 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSNK2A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGCAGTTA
    CSNK2A2 Expression
    About this image


    CSNK2A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Testis (Reproductive System)
             Seminiferous Tubules
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    CSNK2A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSNK2A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.82201
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSNK2A2 (see all 6): 
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSNK2A2 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csnk2a21 , 5 casein kinase 2, alpha prime polypeptide1, 5 94.86(n)1
    98.86(a)1
      8 (47.12 cM)5
    130001  NM_009974.31  NP_034104.11 
     954460965 
    chicken
    (Gallus gallus)
    Aves CSNK2A21 casein kinase 2, alpha prime polypeptide 86.57(n)
    97.14(a)
      415626  NM_001012691.1  NP_001012709.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSNK2A26
    casein kinase 2, alpha prime polypeptide
    95(a)
    1 ↔ 1
    GL344501.1(25004-41030)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.21272 Xenopus laevis cDNA clone IMAGE4960119, containing more 76.85(n)    BC059309.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ck2a22 casein kinase 2 alpha 2 80.25(n)   30488  BC044342.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CKA11 CKA1 62.29(n)
    66.87(a)
      854776   NP_012229.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G230801 AT2G23080 67.38(n)
    71.78(a)
      816838  NM_127872.3  NP_179890.1 
    rice
    (Oryza sativa)
    Liliopsida Os.19552 Oryza sativa casein kinase mRNA, partial cds 75.94(n)    NM_194133.1 


    ENSEMBL Gene Tree for CSNK2A2 (if available)
    TreeFam Gene Tree for CSNK2A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSNK2A2 gene
    CSNK2A12  CSNK2A32  
    15 SIMAP similar genes for CSNK2A2 using alignment to 4 protein entries:     CSK22_HUMAN (see all proteins):
    CSNK2A1    CSNK2A3    CSNK1A1    CDK7    DYRK4    CDK2
    CDK3    CDK5    CDK11B    MAPK12    MAPK13    MAPK11
    MAPK14    MAPK1    MOK

    Find genes that share paralogs with CSNK2A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSNK2A2 (see all 784)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422588711,2
    --58191333(+) TCTTAA/CCACCA 1 -- int10--------
    rs1896251331,2
    --58191336(+) TAACAC/TCACTC 1 -- int10--------
    rs1823076111,2
    --58191363(+) CCTTAC/TAAACG 1 -- int10--------
    rs38377541,2
    C--58191499(+) TCTACA/-AAAAA 1 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs373571,2
    C,F,H--58191966(+) CGAGTT/CGAGGG 1 -- ut31 ese330Minor allele frequency- C:0.01EA NA MN NS WA CSA 2495
    rs1460147591,2
    --58192007(+) CTGCAC/TACCCT 1 -- ut310--------
    rs1478301561,2
    --58192068(+) GGCAAA/GTGAGC 1 -- ut310--------
    rs1488682221,2
    --58192180(+) GGAACA/GTGATC 1 -- ut310--------
    rs1876044011,2
    --58192205(+) AAGACA/GTTTGA 1 -- ut310--------
    rs1920330431,2
    --58192209(+) CGTTTA/GATTTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CSNK2A2 (58191811 - 58231824 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CSNK2A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665560CNV Deletion23128226
    esv2659878CNV Deletion23128226
    esv23104CNV Loss19812545
    nsv457491CNV Loss19166990
    nsv819431CNV Loss19587683

    Human Gene Mutation Database (HGMD): CSNK2A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSNK2A2
    DNA2.0 Custom Variant and Variant Library Synthesis for CSNK2A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 115442    OMIM disorders: --

    3 diseases for CSNK2A2:    
    About MalaCards
    theileriasis    globozoospermia    pandas

    1 disease from the University of Copenhagen DISEASES database for CSNK2A2:
    Theileriasis

    Find genes that share disorders with CSNK2A2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CSNK2A2 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    globozoospermia 59.3 6 10471512 (3), 12778326 (1), 15746197 (1)
    theileriosis 31.5 2 7846527 (1), 9172313 (1)
    retinoblastoma 20.3 1 1325643 (1)
    paired helical filament 12.9 1 1576530 (1)
    astrocytoma 0 1 16520553 (1)
    leukemia 0 1 7852847 (1)
    insulin resistance 0 1 1999482 (1)
    herpes simplex 0 2 7991547 (1), 9312161 (1)
    vesicular stomatitis 0 1 9185603 (1)
    necrosis 0 2 15475455 (1), 10938077 (1)

    Genetic Association Database (GAD): CSNK2A2
    Human Genome Epidemiology (HuGE) Navigator: CSNK2A2 (5 documents)

    Export disorders for CSNK2A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSNK2A2 gene, integrated from 10 sources (see all 540):
    (articles sorted by number of sources associating them with CSNK2A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. (PubMed id 2174700)1, 2, 3, 9 Lozeman F.J....Krebs E.G. (Biochemistry 1990)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. (PubMed id 12393879)1, 2 Keller D.M. and Lu H. (J. Biol. Chem. 2002)
    6. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. (PubMed id 11239457)1, 2 Keller D.M.... Lu H. (Mol. Cell 2001)
    7. Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells. (PubMed id 11704824)1, 2 Sayed M.... Salh B. (Oncogene 2001)
    8. Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. (PubMed id 1766873)1, 3 Yang-Feng T.L....Canaani D. (Nucleic Acids Res. 1991)
    9. The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin. (PubMed id 7689229)1, 9 Jin Y.J. and Burakoff S.J. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    10. Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit. (PubMed id 10471512)1, 9 Xu X....Seldin D.C. (Nat. Genet. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1459 HGNC: 2459 AceView: CSNK2A2 Ensembl:ENSG00000070770 euGenes: HUgn1459
    ECgene: CSNK2A2 Kegg: 1459 H-InvDB: CSNK2A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CSNK2A2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSNK2A2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSNK2A2 gene:
    Search GeneIP for patents involving CSNK2A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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