CSNK2A1 Gene
protein-coding GIFtS: 68
GCID: GC20M000459
|
|
casein kinase 2, alpha 1 polypeptide
| |
Aliases
for CSNK2A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Casein Kinase 2, Alpha 1 Polypeptide1 2 | | Casein Kinase II Alpha 1 Subunit2 | | CK2A12 3 5 | | Casein Kinase II Subunit Alpha2 | | CK II Alpha2 3 | | CK2 Catalytic Subunit Alpha2 | | EC 2.7.11.13 8 | | Protein Kinase CK22 | | CKII2 | | EC 2.7.118 |
Export aliases for CSNK2A1 gene to outside databasesPrevious GC identifers: GC20M000451 GC20M000458 GC20M000414 |
Summaries
for CSNK2A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CSNK2A1:
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinaseexists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits containthe catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this generepresents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found onchromosome 11. Three transcript variants encoding two different proteins have been found for this gene. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CSK21_HUMAN, P68400Function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates alarge number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulatesnumerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection.May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellularresponse. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) thatmaintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediatedapoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis.Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 fromcleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulatestranscription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulatesnumerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB.Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wntsignaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylatesseveral extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral lifecycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV
 summary
for CSNK2A1: Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase
that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2
functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha
and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are
catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the
alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins
implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought
to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the
phosphorylation of Akt.
Gene Wiki entry for CSNK2A1 (Casein kinase 2, alpha 1)
|
Genomic Views
for CSNK2A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CSNK2A1 gene promoter:
TBP TFIID
Other transcription factors
Search SABiosciences Chromatin IP Primers for CSNK2A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK2A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13CSNK2A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M000459: view genomic region
(about GC identifiers)
Start:
|
459,116 bp from pter |
End:
|
524,482 bp from pter |
Size:
|
65,367 bases |
Orientation:
|
minus strand |
|
Proteins
for CSNK2A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CSK21_HUMAN, P68400 (See
protein sequence)Recommended Name: Casein kinase II subunit alpha Size: 391 amino acids; 45144 Da
Subunit: Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatorysubunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha'/2 beta or 1 alpha/1alpha'/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 andCSNK2B, which forms following UV irradiation. Interacts with RNPS1. Interacts with SNAI1
Miscellaneous: Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated torepresent up to one quarter of the eukaryotic phosphoproteome. Casein kinase 2 has been found to be increased atprotein level and up-regulated at the level of enzyme activity in the majority of cancers. However, elevated levels ofcasein kinase 2 are present in certain normal organs such as brain and testes
6/42 PDB 3D structures from  and Proteopedia  for CSNK2A1 (see all 42):1JWH (3D)
1NA7 (3D)
1PJK (3D)
2PVR (3D)
2ZJW (3D)
3AMY (3D)
Secondary accessions: B4DYS6 D3DVV8 P19138 P20426 Q14013 Q5U065Alternative splicing: 2 isoforms: P68400-1 P68400-2 Explore the universe of human proteins at neXtProt for CSNK2A1: NX_P68400
Post-translational modifications:
Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated duringanaphase. Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its regulation byforming binding sites for interacting proteins and/or targeting it to different compartments1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P68400
4/25 DME Specific Peptides for CSNK2A1 (P68400) (see all 25)
CSNK2A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001886.1 NP_808227.1 NP_808228.1
ENSEMBL proteins: ENSP00000339247 ENSP00000217244 ENSP00000383086 ENSP00000383076 Reactome Protein details: P68400
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
CSNK2A1 for ontologies About GeneDecksing
CSNK2A1 Antibody Products:
Assay Products for CSNK2A1: |
Protein
Domains /
Families
for CSNK2A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CSNK2A1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P68400ProtoNet protein and cluster: P68400 UniProtKB/Swiss-Prot: CSK21_HUMAN, P68400Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamilySimilarity: Contains 1 protein kinase domain |
Function
for CSNK2A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CSK21_HUMAN, P68400Function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates alarge number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulatesnumerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection.May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellularresponse. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) thatmaintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediatedapoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis.Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 fromcleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulatestranscription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulatesnumerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB.Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wntsignaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylatesseveral extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral lifecycles of EBV, HSV, HBV, HCV, HIV, CMV and HPVCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Constitutively active protein kinase whose activity is not directly affected by phosphorylation.Seems to be regulated by level of expression and localization Genatlas biochemistry entry for CSNK2A1:casein kinase II,catalytic unit,alpha 1,ubiquitously expressed,likely involved in regulation of cell growth,alsoputative target and regulator of RaF/MAPK signaling,as a free CK2 beta (CSNK2B) form
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Inhib. RNA
Products: |  | EMD Millipore RNAi Products for the Analysis of CSNK2A1 Gene knock-down | |  | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSNK2A1 (see all 7)
OriGene shRNA RFP: CSNK2A1
OriGene siRNA: CSNK2A1
| | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSNK2A1 |
Clone
Products: | | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK2A1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK2A1 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): CSNK2A1 (NM_177559) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CSNK2A1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK2A1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2A1 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
CSNK2A1 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for CSNK2A1:
Animal Models:
Mouse knock-out Csnk2a1tm1Dcs for CSNK2A1
10 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Csnk2a1):
CSNK2A1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CSNK2A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/26 super-pathways (see all 26) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Development_CNTF receptor signaling | | | 3 | M Phase | | | 4 | Cell Cycle | | | 5 | Non-homologous end-joining | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for CSNK2A1
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSNK2A1
2 
Cell Signaling Technology (CST) Pathways for CSNK2A1
1 Tocris Bioscience Pathway for CSNK2A1
4  GeneGo (Thomson Reuters) Pathways for CSNK2A1
5/8  BioSystems Pathways for CSNK2A1 (see all 8)
5/10 
Reactome Pathways for CSNK2A1 (see all 10)
5 
Kegg Pathways (Kegg details for CSNK2A1):
CSNK2A1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSNK2A1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/325 Interacting proteins for CSNK2A1 (P684001, 2, 3 ENSP000002172444) via UniProtKB, MINT, STRING, and/or I2D (see all 325)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PIN1 | Q135262, 3, ENSP000002479704 | MINT-15821 MINT-15822 I2D:
score=4 STRING: ENSP00000247970 | | RELA | Q042062, 3, ENSP000003842734 | MINT-50130 MINT-50090 I2D:
score=4 STRING: ENSP00000384273 | | YWHAB | P319462, 3, ENSP000003001614 | MINT-50947 I2D:
score=5 STRING: ENSP00000300161 | | ZHX1 | Q9UKY12, 3, ENSP000002978574 | MINT-63998 I2D:
score=4 STRING: ENSP00000297857 | | PML | P295901, 3, ENSP000002680584 | EBI-347804,EBI-870812 I2D:
score=3 STRING: ENSP00000268058 |
About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
CSNK2A1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CSNK2A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CSNK2A1 for compounds About GeneDecksing
Compounds for CSNK2A1 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| TMCB | Dual-kinase inhibitor; inhibits CK2 and ERK8 | [905105-89-7] | | TBB | Selective cell-permeable CK2 inhibitor | [17374-26-4] | | Ellagic acid | Selective inhibitor of CK2. Also inhibits glutathione S-transferase | [476-66-4] |
2 HMDB Compounds for CSNK2A1 About this table
10/23 DrugBank Compounds for CSNK2A1 (see all 23) About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| Benzamidine | -- | 618-39-3 | target | -- | 17139284 17016423 10592235 | | Phosphoaminophosphonic Acid-Adenylate Ester | -- | -- | target | -- | 17139284 17016423 10592235 | | Tetrabromo-2-Benzotriazole | -- | -- | target | -- | 17139284 17016423 10592235 | | (5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid | -- | -- | target | -- | 10592235 | | 1,2,5,8-tetrahydroxyanthracene-9,10-dione | -- | -- | target | -- | 10592235 | | 1,8-Di-Hydroxy-4-Nitro-Anthraquinone | -- | -- | target | -- | 10592235 | | 1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One | -- | -- | target | -- | 10592235 | | 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one | -- | -- | target | -- | 10592235 | | 2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione | -- | -- | target | -- | 10592235 | | 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE | -- | -- | target | -- | 10592235 |
10/65 Novoseek chemical compound relationships for CSNK2A1 gene (see all 65) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 4,5,6,7-tetrabromobenzotriazole |
93.2 |
11 |
11988074 (2), 18548199 (1), 16687488 (1), 12869192 (1) (see all 5) |
| dmat |
83.1 |
2 |
20383646 (1), 19424641 (1) |
| 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole |
77.3 |
10 |
18556661 (1), 20026644 (1), 11593402 (1), 12748192 (1) (see all 9) |
| threonine |
76.4 |
67 |
12748192 (2), 1590772 (1), 8529132 (1), 8943850 (1) (see all 64) |
| serine |
75.2 |
101 |
10448092 (3), 8384219 (2), 1425701 (2), 15823605 (2) (see all 87) |
| apigenin |
64.5 |
5 |
11673497 (1), 15302569 (1), 16520553 (1), 16442104 (1) (see all 5) |
| 5,6-dichlorobenzimidazole riboside |
63.8 |
2 |
8765099 (1), 19043076 (1) |
| gtp |
55.4 |
17 |
8049218 (1), 7735321 (1), 10197447 (1), 10398759 (1) (see all 14) |
| phosphocellulose |
54.8 |
6 |
8696255 (1), 9143340 (1), 2040287 (1), 1835512 (1) |
| glycyrrhetinic acid |
53.5 |
2 |
9654140 (1), 10443459 (1) |
Search CenterWatch for drugs/clinical trials and news about CSNK2A1 / CSK21
|
Transcripts
for CSNK2A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CSNK2A1 gene (3 alternative transcripts): NM_001895.3 NM_177559.2 NM_177560.2 Unigene Cluster for CSNK2A1: Casein kinase 2, alpha 1 polypeptide Hs.644056 [show with all ESTs]Unigene Representative Sequence: NM_1775595 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000349736(uc002wdx.1) ENST00000217244(uc002wdw.1) ENST00000460062
ENST00000400227 ENST00000400217(uc002wdy.1)
Inhib. RNA
Products: | | EMD Millipore RNAi Products for the Analysis of CSNK2A1 Gene knock-down | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSNK2A1 (see all 7)
OriGene shRNA RFP: CSNK2A1
OriGene siRNA: CSNK2A1
| | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSNK2A1 |
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK2A1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK2A1 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): CSNK2A1 (NM_177559) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CSNK2A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK2A1 |
Additional cDNA sequence: AB451279.1 AB451411.1 AK302583.1 AK312535.1 AY735339.1 BC002615.2 BC011668.2 BC050036.1 BC053532.1 BC071167.1 BT019792.1 DQ354583.1 J02853.1 M55265.1 S53149.1 21 DOTS entries: DT.99935781 DT.456148 DT.100821389 DT.100821391 DT.101957241 DT.100821379 DT.100821384 DT.97855916 DT.100707032 DT.91745722 DT.100821387 DT.95258504 DT.100739418 DT.120821869 DT.120821893 DT.120821992 DT.40245765 DT.92445999 DT.120821972 DT.95258004 DT.99936596 24/419 AceView cDNA sequences (see all 419): AI968389 CB160720 N35932 BM666326 AU120646 AU132296 AI369514 AU131227 AL601215 AL597675 AI804464 AU133318 BF058791 BU742389 BE550309 BQ000532 BE408670 AW014368 BM784576 BM718736 AI470508 BM683364 BU507740 BG149299
GeneLoc Exon Structure
|
Expression
for CSNK2A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CSNK2A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCATCCAGTG
About this image
See CSNK2A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CSNK2A1
SOURCE GeneReport for Unigene cluster: Hs.644056
SABiosciences Expression via Pathway-Focused PCR Arrays including CSNK2A1 (see all 7):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSNK2A1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSNK2A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSNK2A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSNK2A1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2A1 |
Orthologs
for CSNK2A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CSNK2A1 gene from 9/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CSNK2A11 |
casein kinase 2, alpha 1 polypeptide |
86.87(n)
97.95(a) |
|
432370 NM_001002242.1 NP_001002242.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CSNK2A16 |
-- |
96(a) |
1 ↔ 1 |
GL343346.1(62790-83271) |
African clawed frog
(Xenopus laevis) |
Amphibia |
X62375.22 |
-- |
79.97(n) |
|
X62375.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
ck2a12 |
casein kinase 2 alpha 1 |
80.71(n) |
|
30502 BC044403.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CkIIalpha1 , 3 |
frizzled receptor signaling pathway protein
kinase3
Casein kinase II alpha subunit1 |
88(a)3
73.39(n)1
88.69(a)1 |
|
80D23
484481 NM_080179.41 NP_524918.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
B0205.73
kin-31 |
casein kinase3
Protein KIN-31 |
83(a)3
69.11(n)1
78.59(a)1 |
|
I(10742092-10744293)3
1729781 NM_060410.31 NP_492811.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CKA1(YIL035C)4
CKA21 |
Alpha catalytic subunit of casein kinase 2 (CK2), a more4
Cka2p1 |
57.41(n)1
59.88(a)1 |
|
9(288908-287790)4
8542271 NP_014704.11 8547764
NP_012229.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CKA21 |
casein kinase II, alpha chain 2 |
67.18(n)
75.23(a) |
|
824162 NM_114860.3 NP_190569.2 |
rice
(Oryza sativa) |
Liliopsida |
Os07g01144001 |
hypothetical protein |
67.38(n)
77.2(a) |
|
4342248 NM_001065287.1 NP_001058752.1 |
ENSEMBL Gene Tree for CSNK2A1 (if available)
TreeFam Gene Tree for CSNK2A1 (if available) |
Paralogs
for CSNK2A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CSNK2A1 gene
- CSNK2A22
18/20 SIMAP similar genes for CSNK2A1 using alignment to 4 protein entries: CSK21_HUMAN (see all proteins)
(see all similar genes):CSNK2A2 RPS6KA2 CDK3 CDK2 MAPK3 CDK1
NUAK1 STK11 CCRK CDK4 DKFZp686O0215 CDK5
DKFZp686L20222 MAPK1 MAPK13 CDKL4 MAPK14 MAPK12
CSNK2A1 for paralogs About GeneDecksing
|
Genomic Variants
for CSNK2A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CSNK2A1 (459116 - 524482 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CSNK2A1
2 CNVs: 2250 5120
Locus Specific Mutation Databases (LSDB): CSNK2A1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSNK2A1 |
|
Disorders
/ Diseases
for CSNK2A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CSNK2A1 for disorders About GeneDecksing
OMIM gene information: 115440
OMIM disorders: --
20/52  diseases for CSNK2A1 (see all 52): About MalaCardsdna topoisomerase ii adenomatous polyposis coli squamous cell carcinoma bipolar i disorder
laryngeal squamous cell carcinoma globozoospermia squamous cell carcinoma of the head and neck systemic lupus erythematosus
lupus erythematosus schizoaffective disorder acute lymphoblastic leukemia lymphoblastic leukemia
stomatitis insulin resistance laryngitis adrenocortical carcinoma
wilms tumor polyposis carcinoma multiple myeloma
10/26 Novoseek disease relationships for CSNK2A1 gene (see all 26) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinal neovascularization |
29.9 |
3 |
15557471 (1), 18612802 (1), 16651637 (1) |
| cancer |
27.2 |
25 |
19387548 (2), 14965269 (2), 9820486 (1), 12149649 (1) (see all 22) |
| prostate carcinoma |
25.5 |
2 |
12738992 (1), 16687488 (1) |
| mammary tumor |
22.8 |
1 |
17575143 (1) |
| tumors |
17.1 |
20 |
8037705 (2), 12479100 (1), 9042966 (1), 10862016 (1) (see all 19) |
| prostate cancer |
8.98 |
7 |
17044081 (2), 12738992 (1), 16489027 (1), 18574673 (1) (see all 6) |
| metastasis |
2.81 |
1 |
18062282 (1) |
| carcinoma |
2.33 |
1 |
10533285 (1) |
| t-all |
1.49 |
1 |
8895560 (1) |
| astrocytoma |
0 |
1 |
16520553 (1) |
Human Genome Epidemiology (HuGE) Navigator: CSNK2A1 (8 documents)
Export disorders for CSNK2A1 gene to outside databases
|
Publications
for CSNK2A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CSNK2A1 gene, integrated from 9 sources (see all 798):
(articles sorted by number of sources associating them with CSNK2A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. (PubMed id 2174700)1, 2, 3 Lozeman F.J....Krebs E.G. (1990)
- Protein kinase CK2 in health and disease: CK2: the ki nase controlling the Hsp90 chaperone machinery. (PubMed id 19387550)1, 2, 9 Miyata Y. (2009)
- Mapping of the human casein kinase II catalytic subun it genes: two loci carrying the homologous sequences for the alpha subunit. (PubMed id 1766873)1, 3, 9 Yang-Feng T.L....Canaani D. (1991)
- Phosphorylation of serine 11 and serine 92 as new pos itive regulators of human Snail1 function: potential involvement of casein kina se-2 and the cAMP-activated kinase protein kinase A. (PubMed id 19923321)1, 2 MacPherson M.R....Cano A. (2010)
- Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8. (PubMed id 16193064)1, 2 Shin S....Kim K. (2005)
- Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation. (PubMed id 15684395)1, 2 Trembley J.H.... Mayeda A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2. (PubMed id 14646071)1, 2 Pechkova E.... Nicolini C. (2003)
- Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit. (PubMed id 12860116)1, 2 Ermakova I.... Niefind K. (2003)
- p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. (PubMed id 12393879)1, 2 Keller D.M. and Lu H. (2002)
|
External Searches for CSNK2A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CSNK2A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CSNK2A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CSNK2A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CSNK2A1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CSNK2A1 gene:
Search GeneIP for patents involving CSNK2A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CSNK2A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CSNK2A1 | | OriGene shRNA RFP for CSNK2A1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSNK2A1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSNK2A1 | | | OriGene Protein Over-expression Lysate for CSNK2A1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CSNK2A1 | | OriGene 3'-UTR Clone for CSNK2A1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK2A1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK2A1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CSNK2A1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CSNK2A1 | | OriGene Custom Protein Services for CSNK2A1 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CSNK2A1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSNK2A1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK2A1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSNK2A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSNK2A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSNK2A1 |
| |
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| | | |  |  |  |  | | | | |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2A1 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK2A1 |
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