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Aliases for CSNK2A1 Gene

Aliases for CSNK2A1 Gene

  • Casein Kinase 2, Alpha 1 Polypeptide 2 3
  • CK2A1 3 4 6
  • EC 2.7.11.1 4 63
  • Casein Kinase II Alpha 1 Polypeptide Pseudogene 3
  • Casein Kinase II Alpha 1 Subunit 3
  • Casein Kinase II Subunit Alpha 3
  • CK2 Catalytic Subunit Alpha 3
  • Protein Kinase CK2 3
  • CK II Alpha 3 3
  • CK II Alpha 4
  • EC 2.7.11 63
  • CSNK2A3 3
  • CKII 3

External Ids for CSNK2A1 Gene

Previous GeneCards Identifiers for CSNK2A1 Gene

  • GC20M000451
  • GC20M000458
  • GC20M000414

Summaries for CSNK2A1 Gene

Entrez Gene Summary for CSNK2A1 Gene

  • Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for CSNK2A1 Gene

CSNK2A1 (Casein Kinase 2, Alpha 1 Polypeptide) is a Protein Coding gene. Diseases associated with CSNK2A1 include malaria. Among its related pathways are L1CAM interactions and NF-KappaB Family Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and beta-catenin binding. An important paralog of this gene is CSNK2A2.

UniProtKB/Swiss-Prot for CSNK2A1 Gene

  • Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating Ser-392 of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at Ser-565 and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at Ser-90 which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry.

Tocris Summary for CSNK2A1 Gene

  • Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.

Gene Wiki entry for CSNK2A1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK2A1 Gene

Genomics for CSNK2A1 Gene

Regulatory Elements for CSNK2A1 Gene

Transcription factor binding sites by QIAGEN in the CSNK2A1 gene promoter:

Genomic Location for CSNK2A1 Gene

Start:
473,322 bp from pter
End:
543,838 bp from pter
Size:
70,517 bases
Orientation:
Minus strand

Genomic View for CSNK2A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSNK2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK2A1 Gene

Proteins for CSNK2A1 Gene

  • Protein details for CSNK2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68400-CSK21_HUMAN
    Recommended name:
    Casein kinase II subunit alpha
    Protein Accession:
    P68400
    Secondary Accessions:
    • B4DYS6
    • D3DVV8
    • P19138
    • P20426
    • Q14013
    • Q5U065

    Protein attributes for CSNK2A1 Gene

    Size:
    391 amino acids
    Molecular mass:
    45144 Da
    Quaternary structure:
    • Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha/2 beta or 1 alpha/1 alpha/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation. Interacts with RNPS1. Interacts with SNAI1. Interacts with PML (isoform PML-12).
    Miscellaneous:
    • Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome. Casein kinase 2 has been found to be increased at protein level and up-regulated at the level of enzyme activity in the majority of cancers. However, elevated levels of casein kinase 2 are present in certain normal organs such as brain and testes

    Three dimensional structures from OCA and Proteopedia for CSNK2A1 Gene

    Alternative splice isoforms for CSNK2A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSNK2A1 Gene

Proteomics data for CSNK2A1 Gene at MOPED

Post-translational modifications for CSNK2A1 Gene

  • Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase. Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its regulation by forming binding sites for interacting proteins and/or targeting it to different compartments.
  • Ubiquitination at Lys83, Lys102, Lys122, Lys229, Lys303, and Lys329
  • Modification sites at PhosphoSitePlus

Other Protein References for CSNK2A1 Gene

Domains for CSNK2A1 Gene

Graphical View of Domain Structure for InterPro Entry

P68400

UniProtKB/Swiss-Prot:

CSK21_HUMAN :
  • P68400
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
genes like me logo Genes that share domains with CSNK2A1: view

Function for CSNK2A1 Gene

Molecular function for CSNK2A1 Gene

GENATLAS Biochemistry: casein kinase II,catalytic unit,alpha 1,ubiquitously expressed,likely involved in regulation of cell growth,also putative target and regulator of RaF/MAPK signaling,as a free CK2 beta (CSNK2B) form
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization
UniProtKB/Swiss-Prot Function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating Ser-392 of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at Ser-565 and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at Ser-90 which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry.

Enzyme Numbers (IUBMB) for CSNK2A1 Gene

Gene Ontology (GO) - Molecular Function for CSNK2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS 2174700
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 10094392
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CSNK2A1: view
genes like me logo Genes that share phenotypes with CSNK2A1: view

Animal Models for CSNK2A1 Gene

MGI Knock Outs for CSNK2A1:

No data available for Transcription Factor Targeting and HOMER Transcription for CSNK2A1 Gene

Localization for CSNK2A1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK2A1 Gene COMPARTMENTS Subcellular localization image for CSNK2A1 gene
Compartment Confidence
cytosol 4
nucleus 4
plasma membrane 4
cytoskeleton 2
chloroplast 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSNK2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21282530
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS 10799509
GO:0016580 Sin3 complex IDA 17827154
GO:0016581 NuRD complex IDA 17827154
genes like me logo Genes that share ontologies with CSNK2A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CSNK2A1 Gene

Pathways for CSNK2A1 Gene

genes like me logo Genes that share pathways with CSNK2A1: view

Gene Ontology (GO) - Biological Process for CSNK2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IDA 20625391
GO:0007165 signal transduction TAS 2174700
genes like me logo Genes that share ontologies with CSNK2A1: view

Compounds for CSNK2A1 Gene

(4) Tocris Compounds for CSNK2A1 Gene

Compound Action Cas Number
Ellagic acid Selective inhibitor of CK2. Also inhibits glutathione S-transferase [476-66-4]
TBB Selective cell-permeable CK2 inhibitor [17374-26-4]
TMCB Dual-kinase inhibitor; inhibits CK2 and ERK8 [905105-89-7]
TTP 22 High affinity, selective CK2 inhibitor [329907-28-0]

(2) HMDB Compounds for CSNK2A1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(65) Novoseek inferred chemical compound relationships for CSNK2A1 Gene

Compound -log(P) Hits PubMed IDs
4,5,6,7-tetrabromobenzotriazole 93.2 6
dmat 83.1 2
5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 77.3 9
threonine 76.4 65
serine 75.2 92
genes like me logo Genes that share compounds with CSNK2A1: view

Transcripts for CSNK2A1 Gene

Unigene Clusters for CSNK2A1 Gene

Casein kinase 2, alpha 1 polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK2A1 Gene

No ASD Table

Relevant External Links for CSNK2A1 Gene

GeneLoc Exon Structure for
CSNK2A1
ECgene alternative splicing isoforms for
CSNK2A1

Expression for CSNK2A1 Gene

mRNA expression in normal human tissues for CSNK2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSNK2A1 Gene

SOURCE GeneReport for Unigene cluster for CSNK2A1 Gene Hs.644056

genes like me logo Genes that share expressions with CSNK2A1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSNK2A1 Gene

Orthologs for CSNK2A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK2A1 35
  • 93.25 (n)
  • 91.41 (a)
cow
(Bos Taurus)
Mammalia CSNK2A1 35
  • 96.5 (n)
  • 99.74 (a)
CSNK2A1 36
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 100 (a)
OneToMany
CSNK2A1 35
  • 96.76 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Csnk2a1 35
  • 94.54 (n)
  • 98.72 (a)
Csnk2a1 16
Csnk2a1 36
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Csnk2a1 35
  • 93.86 (n)
  • 98.47 (a)
chicken
(Gallus gallus)
Aves CSNK2A1 35
  • 86.87 (n)
  • 97.95 (a)
CSNK2A1 36
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 95 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498392 35
  • 79.26 (n)
  • 94.14 (a)
Str.714 35
zebrafish
(Danio rerio)
Actinopterygii ck2a1 35
ck2a1 36
  • 87 (a)
ManyToMany
LOC100535532 35
  • 73.2 (n)
  • 81.44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005569 35
  • 69.31 (n)
  • 86.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CkIIalpha 35
  • 73.39 (n)
  • 88.69 (a)
CkIIalpha 36
  • 86 (a)
OneToMany
CkIIalpha 37
  • 88 (a)
worm
(Caenorhabditis elegans)
Secernentea kin-3 35
  • 69.11 (n)
  • 78.59 (a)
kin-3 36
  • 78 (a)
OneToMany
B0205.7 37
  • 83 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR204W 35
  • 59.01 (n)
  • 59.01 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKA1 38
CKA2 35
  • 57.41 (n)
  • 59.88 (a)
CKA2 36
  • 57 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16467g 35
  • 59.52 (n)
  • 59.63 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G23070 35
  • 69.35 (n)
  • 75.54 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03124 35
  • 66.14 (n)
  • 71.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cka1 35
  • 62.95 (n)
  • 66.25 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14189 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11074 36
  • 86 (a)
OneToMany
Species with no ortholog for CSNK2A1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK2A1 Gene

ENSEMBL:
Gene Tree for CSNK2A1 (if available)
TreeFam:
Gene Tree for CSNK2A1 (if available)

Paralogs for CSNK2A1 Gene

Paralogs for CSNK2A1 Gene

genes like me logo Genes that share paralogs with CSNK2A1: view

Variants for CSNK2A1 Gene

Sequence variations from dbSNP and Humsavar for CSNK2A1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs68488 -- 507,789(+) TATCA(A/C)TTCTC intron-variant
rs74119 -- 508,286(-) AGTGA(A/G)GAAGC intron-variant
rs77725 -- 475,808(-) TCATG(A/G)ATCAC intron-variant
rs77726 -- 475,605(-) ATTAC(A/G)GGGGA intron-variant
rs87167 -- 475,191(-) gtgag(A/C)caccg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK2A1 Gene

Variant ID Type Subtype PubMed ID
dgv4509n71 CNV Gain 21882294
nsv469833 CNV Gain 16826518
nsv833891 CNV Gain+Loss 17160897
esv2673541 CNV Deletion 23128226
esv2674635 CNV Deletion 23128226

Relevant External Links for CSNK2A1 Gene

HapMap Linkage Disequilibrium report
CSNK2A1
Locus Specific Mutation Databases (LSDB)
CSNK2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK2A1 Gene

Disorders for CSNK2A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CSNK2A1 Gene including...

Search for CSNK2A1 Gene in MalaCards »

(26) Novoseek inferred disease relationships for CSNK2A1 Gene

Disease -log(P) Hits PubMed IDs
retinal neovascularization 29.9 3
cancer 27.2 24
prostate carcinoma 25.5 2
mammary tumor 22.8 1
tumors 17.1 20

Relevant External Links for CSNK2A1

Genetic Association Database (GAD)
CSNK2A1
Human Genome Epidemiology (HuGE) Navigator
CSNK2A1
genes like me logo Genes that share disorders with CSNK2A1: view

No data available for UniProtKB/Swiss-Prot for CSNK2A1 Gene

Publications for CSNK2A1 Gene

  1. Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. (PMID: 1766873) Yang-Feng T.L. … Canaani D. (Nucleic Acids Res. 1991) 2 3 23
  2. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. (PMID: 2174700) Lozeman F.J. … Krebs E.G. (Biochemistry 1990) 2 3 4
  3. Involvement of reactive oxygen species in apoptosis induced by pharmacological inhibition of protein kinase CK2. (PMID: 19723109) Hanif I.M. … Pervaiz S. (Ann. N. Y. Acad. Sci. 2009) 3 23
  4. [Effect of protein kinase CK2 gene silencing on radiosensitization in human nasopharyngeal carcinoma cells]. (PMID: 19726289) Liu L. … Wu D.H. (Nan Fang Yi Ke Da Xue Xue Bao 2009) 3 23
  5. Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol. (PMID: 20026644) von Knethen A. … BrA1ne B. (J. Cell. Sci. 2010) 3 23

Products for CSNK2A1 Gene

Sources for CSNK2A1 Gene

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