Aliases for CSNK2A1 Gene
Aliases for CSNK2A1 Gene
External Ids for CSNK2A1 Gene
- HGNC: 2457
- Entrez Gene: 1457
- Ensembl: ENSG00000101266
- OMIM: 115440
- UniProtKB: P68400
Previous GeneCards Identifiers for CSNK2A1 Gene
- GC20M000451
- GC20M000458
- GC20M000414
Summaries for CSNK2A1 Gene
-
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]
GeneCards Summary for CSNK2A1 Gene
CSNK2A1 (Casein Kinase 2 Alpha 1) is a Protein Coding gene. Diseases associated with CSNK2A1 include Okur-Chung Neurodevelopmental Syndrome and Cardiomyopathy, Dilated, 1P. Among its related pathways are Regulation of TP53 Activity and DNA damage_NHEJ mechanisms of DSBs repair. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK2A3.
UniProtKB/Swiss-Prot for CSNK2A1 Gene
-
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating Ser-392 of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at Ser-565 and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at Ser-90 which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at Thr-454 in gastric carcinoma tissue (PubMed:24962073).
-
Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase thought to have a regulatory function in cell proliferation, differentiation and apoptosis. CK2 functions as a tetrameric complex with 2 regulatory and 2 catalytic subunits.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK2A1 Gene
Genomics for CSNK2A1 Gene
Regulatory Elements for CSNK2A1 Gene
Enhancers for CSNK2A1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CSNK2A1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CSNK2A1 gene promoter:
Regulatory Element Products
Genomic Location for CSNK2A1 Gene
- Chromosome:
- 20
- Start:
- 472,969 bp from pter
- End:
- 543,838 bp from pter
- Size:
- 70,870 bases
- Orientation:
- Minus strand
Genomic View for CSNK2A1 Gene
Genes around CSNK2A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20p13 by Ensembl
- 20p13 by Entrez Gene
- 20p13 by HGNC
CSNK2A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CSNK2A1 Gene
Proteins for CSNK2A1 Gene
-
Protein details for CSNK2A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P68400-CSK21_HUMAN
- Recommended name:
- Casein kinase II subunit alpha
- Protein Accession:
- P68400
- B4DYS6
- D3DVV8
- P19138
- P20426
- Q14013
- Q5U065
Protein attributes for CSNK2A1 Gene
- Size:
- 391 amino acids
- Molecular mass:
- 45144 Da
- Quaternary structure:
-
- Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha/2 beta or 1 alpha/1 alpha/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation. Interacts with RNPS1. Interacts with SNAI1. Interacts with PML (isoform PML-12). Interacts with CCAR2.
- Miscellaneous:
-
- Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome. Casein kinase 2 has been found to be increased at protein level and up-regulated at the level of enzyme activity in the majority of cancers. However, elevated levels of casein kinase 2 are present in certain normal organs such as brain and testes.
Three dimensional structures from OCA and Proteopedia for CSNK2A1 Gene
Protein Expression for CSNK2A1 Gene
Selected DME Specific Peptides for CSNK2A1 Gene
- P68400:
-
- RHSRKRWERFVHS
- LDKLLRYDHQ
- NQHLVSPEA
- LIDWGLAE
- GIMHRDVKPHNVMID
- EAMEHPYFY
- LKALDYCHS
- GRGKYSEVF
- REYWDYE
- DNYDQLV
- MPGGSTPVSSA
- LDPRFNDILGRHSRKRWERF
- MIFRKEPFF
- KILENLRGG
- DIRFYMYE
- YQLVRKL
- YNVRVASR
- EVFEAIN
- IAKVLGT
- KKKIKRE
- SPEALDFL
- YDYSLDMWSLGC
- MLASMIF
- PFFHGHDN
- TPALVFE
Post-translational modifications for CSNK2A1 Gene
- Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase. Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its regulation by forming binding sites for interacting proteins and/or targeting it to different compartments.
- Ubiquitination at Lys229
- Modification sites at PhosphoSitePlus
Other Protein References for CSNK2A1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CSNK2A1
- R&D Systems Antibodies for CSNK2A1 (Casein Kinase 2 alpha)
- Cell Signaling Technology (CST) Antibodies for CSNK2A1 (CK2A1)
-
Custom Antibody ServicesOriGene Antibodies for CSNK2A1
- Novus Biologicals Antibodies for CSNK2A1
- Invitrogen Antibodies for CSNK2A1
- antibodies-online Antibodies for CSNK2A1: See all 148
- GeneTex CSNK2A1 antibody for CSNK2A1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CSNK2A1
Protein Products
- EMD Millipore Purified and/or Recombinant CSNK2A1 Protein
-
OriGene Purified Proteins for CSNK2A1
- Search Origene for MassSpec and Protein Over-expression Lysates for CSNK2A1
- Origene Custom Protein Services for CSNK2A1
- Sino Biological Recombinant Proteins for CSNK2A1
- Sino Biological Cell Lysates for CSNK2A1
- ProSpec Recombinant Proteins for CSNK2A1
- antibodies-online Proteins for CSNK2A1: See all 23
- Search antibodies-online for peptides
- GeneTex Proteins for CSNK2A1
Assay Products
- antibodies-online Kits for CSNK2A1: See all 3
Domains & Families for CSNK2A1 Gene
Gene Families for CSNK2A1 Gene
Protein Domains for CSNK2A1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CSNK2A1 Gene
Graphical View of Domain Structure for InterPro Entry
P68400UniProtKB/Swiss-Prot:
CSK21_HUMAN :- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
Function for CSNK2A1 Gene
Molecular function for CSNK2A1 Gene
- GENATLAS Biochemistry:
- casein kinase II,catalytic unit,alpha 1,ubiquitously expressed,likely involved in regulation of cell growth,also putative target and regulator of RaF/MAPK signaling,as a free CK2 beta (CSNK2B) form
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization.
- UniProtKB/Swiss-Prot Function:
- Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating Ser-392 of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at Ser-565 and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at Ser-90 which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at Thr-454 in gastric carcinoma tissue (PubMed:24962073).
Enzyme Numbers (IUBMB) for CSNK2A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IMP,TAS | 2174700 |
| GO:0005515 | protein binding | IPI | 10094392 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IDA | 18548200 |
Phenotypes for CSNK2A1 Gene
- MGI mutant phenotypes for CSNK2A1:
-
inferred from 1 alleles
- mortality/aging
- growth/size/body region phenotype
- muscle phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- limbs/digits/tail phenotype
- embryo phenotype
- pigmentation phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for CSNK2A1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability ratio
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased circadian period length
- Increased Nanog expression
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased telomerase activity
Animal Models for CSNK2A1 Gene
- MGI Knock Outs for CSNK2A1:
-
- Csnk2a1 tm1Dcs
Animal Model Products
-
Taconic Biosciences Mouse Models for CSNK2A1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CSNK2A1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CSNK2A1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK2A1 gene
- Search ViGene Biosciences for CSNK2A1
CRISPR Products
-
OriGene CRISPR knockouts for CSNK2A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSNK2A1
- GenScript: Design CRISPR guide RNA sequences for CSNK2A1
miRNA for CSNK2A1 Gene
- miRTarBase miRNAs that target CSNK2A1
-
- hsa-mir-216b-5p (MIRT007207)
- hsa-mir-337-3p (MIRT007208)
- hsa-mir-760 (MIRT007209)
- hsa-mir-186-5p (MIRT007210)
- hsa-mir-22-3p (MIRT030638)
- hsa-mir-652-3p (MIRT039530)
- hsa-mir-615-3p (MIRT039801)
- hsa-mir-183-5p (MIRT047136)
- hsa-mir-10b-5p (MIRT047431)
- hsa-mir-10a-5p (MIRT047540)
- hsa-let-7c-5p (MIRT051854)
- hsa-let-7b-5p (MIRT052272)
- hsa-let-7a-5p (MIRT052591)
- hsa-mir-125b-5p (MIRT437426)
- hsa-mir-4799-5p (MIRT513956)
- hsa-mir-6765-5p (MIRT513957)
- hsa-mir-1304-5p (MIRT513958)
- hsa-mir-107 (MIRT513959)
- hsa-mir-103a-3p (MIRT513960)
- hsa-mir-3188 (MIRT513961)
- hsa-mir-2467-5p (MIRT513962)
- hsa-mir-3975 (MIRT513963)
- hsa-mir-5009-3p (MIRT513964)
- hsa-mir-485-5p (MIRT513965)
- hsa-mir-6884-5p (MIRT513966)
- hsa-mir-4662a-5p (MIRT538295)
- hsa-mir-3605-5p (MIRT538296)
- hsa-mir-3679-5p (MIRT538297)
- hsa-mir-1185-5p (MIRT538298)
- hsa-mir-138-1-3p (MIRT538299)
- hsa-mir-4319 (MIRT538300)
- hsa-mir-125a-5p (MIRT538301)
- hsa-mir-625-3p (MIRT538302)
- hsa-mir-504-5p (MIRT538303)
- hsa-mir-580-3p (MIRT538304)
- hsa-mir-6867-3p (MIRT538305)
- hsa-mir-6852-3p (MIRT538306)
- hsa-mir-3909 (MIRT538307)
- hsa-mir-6770-5p (MIRT538308)
- hsa-mir-1253 (MIRT538309)
- hsa-mir-7706 (MIRT538310)
- hsa-mir-4685-3p (MIRT538311)
- hsa-mir-4287 (MIRT538312)
- hsa-mir-7113-3p (MIRT538313)
- hsa-mir-4469 (MIRT538314)
- hsa-mir-3162-3p (MIRT538315)
- hsa-mir-3163 (MIRT538316)
- hsa-mir-4695-5p (MIRT538317)
- hsa-mir-6891-5p (MIRT538318)
- hsa-mir-3173-3p (MIRT538319)
- hsa-mir-518e-3p (MIRT538320)
- hsa-mir-2110 (MIRT544554)
- hsa-mir-6780b-5p (MIRT544555)
- hsa-mir-4271 (MIRT544556)
- hsa-mir-4725-3p (MIRT544557)
- hsa-mir-6888-5p (MIRT544558)
- hsa-mir-570-5p (MIRT544559)
- hsa-mir-548ba (MIRT544560)
- hsa-mir-548ai (MIRT544561)
- hsa-mir-548ag (MIRT544562)
- hsa-mir-6809-3p (MIRT624250)
- hsa-mir-6833-3p (MIRT624251)
- hsa-mir-4768-5p (MIRT624252)
- hsa-mir-6873-3p (MIRT624253)
- hsa-mir-5581-3p (MIRT624254)
- hsa-mir-103a-2-5p (MIRT624255)
- hsa-mir-6499-3p (MIRT624256)
- hsa-mir-1205 (MIRT624257)
- hsa-mir-1184 (MIRT624258)
- hsa-mir-3158-5p (MIRT624259)
- hsa-mir-6817-3p (MIRT624260)
- hsa-mir-7110-3p (MIRT624261)
- hsa-mir-6845-3p (MIRT624262)
- hsa-mir-136-5p (MIRT624263)
- hsa-mir-6872-3p (MIRT624264)
- hsa-mir-193a-5p (MIRT624265)
- hsa-mir-4659b-3p (MIRT659326)
- hsa-mir-4659a-3p (MIRT659327)
- hsa-mir-6875-3p (MIRT659328)
- hsa-mir-6868-3p (MIRT659329)
- hsa-mir-6749-3p (MIRT659330)
- hsa-mir-3124-3p (MIRT659331)
- hsa-mir-1248 (MIRT659332)
- hsa-mir-1237-3p (MIRT659333)
- hsa-mir-3667-3p (MIRT659334)
- hsa-mir-6734-3p (MIRT659335)
- hsa-mir-5088-3p (MIRT659336)
- hsa-mir-1260b (MIRT704448)
- hsa-mir-1260a (MIRT704449)
- hsa-mir-188-3p (MIRT704450)
- hsa-mir-4768-3p (MIRT704451)
- hsa-mir-5690 (MIRT704452)
- hsa-mir-646 (MIRT704453)
- hsa-mir-1183 (MIRT704454)
miRNA Products
- Search ViGene Biosciences for CSNK2A1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CSNK2A1
- Browse OriGene Inhibitory RNA Products For CSNK2A1
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK2A1 gene
Clone Products
- Sino Biological Human cDNA Clone for CSNK2A1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CSNK2A1
- VectorBuilder custom plasmid, inducible vectors for CSNK2A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK2A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CSNK2A1
-
ViGene Biosciences adenoviral particle packaged cDNA for CSNK2A1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CSNK2A1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK2A1 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12284) for CSNK2A1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK2A1 Gene
Localization for CSNK2A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CSNK2A1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IDA | 21282530 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | 10799509 |
| GO:0005956 | protein kinase CK2 complex | IDA | 15723517 |
Pathways & Interactions for CSNK2A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell Cycle, Mitotic |
.83
|
.60
|
| 2 | Regulation of TP53 Activity | ||
| 3 | Influenza A |
.34
|
|
| 4 | Developmental Biology |
.51
|
|
| 5 | Chaperonin-mediated protein folding |
.94
|
|
Pathways by source for CSNK2A1 Gene
1 GeneTex pathway for CSNK2A1 Gene
1 Cell Signaling Technology pathway for CSNK2A1 Gene
8 BioSystems pathways for CSNK2A1 Gene
27 Reactome pathways for CSNK2A1 Gene
8 KEGG pathways for CSNK2A1 Gene
4 GeneGo (Thomson Reuters) pathways for CSNK2A1 Gene
1 R&D Systems pathway for CSNK2A1 Gene
1 Tocris pathway for CSNK2A1 Gene
3 Qiagen pathways for CSNK2A1 Gene
Interacting Proteins for CSNK2A1 Gene
Selected Interacting proteins:
P68400-CSK21_HUMAN
ENSP00000217244
for CSNK2A1 Gene via
MINT
STRING
UniProtKB
IID
SIGNOR curated interactions for CSNK2A1 Gene
- Activates:
-
- LEF1
- ATF1
- SSB
- ESR1
- PPP1R2
- CD5
- PTPRC
- MAZ
- PIP4K2A
- SNCA
- PTEN
- RELA
- HDAC1
- STX1A
- UBE2R2
- HDAC2
- CAV2
- RNF7
- WAS
- LIG1
- VAMP4
- PKD2
- PTGES3
- DEK
- XRCC1
- TLE1
- CDK1
- AKT1
- CAPZA1
- EIF2S2
- EIF5
- NPHP1
- SHOX
- RANGAP1
- MCM2
- PDCL
- ANP32B
- FOSB
- VDR
- MYH9
- PRPF3
- TERF1
- MDC1
- TOP2A
- EXOSC9
- PIAS1
- PDCD5
- TNFAIP1
- SNAI1
- CLIP1
- CDC27
- CBX5
- DAXX
- TWIST1
- TFAP2A
- CFTR
- CORO1C
- ABCC1
- YY1
- Inactivates:
- Is activated by:
- Is inactivated by:
- Other effect:
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006457 | protein folding | TAS | -- |
| GO:0006468 | protein phosphorylation | IDA,IEA | 18548200 |
| GO:0006656 | phosphatidylcholine biosynthetic process | TAS | -- |
Drugs & Compounds for CSNK2A1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 | |||
| Resveratrol | Experimental, Investigational | Pharma | Target | Wee1 kinase inhibtor,potent and ATP-competitive, Others, Cyclooxygenase inhibitor | 122 | |
| (5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid | Experimental | Pharma | Target | 0 | ||
| 1,2,5,8-tetrahydroxyanthracene-9,10-dione | Experimental | Pharma | Target | 0 | ||
| 1,8-Di-Hydroxy-4-Nitro-Anthraquinone | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| TBCA |
|
934358-00-6 |
|
|
(5) Tocris Compounds for CSNK2A1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Ellagic acid | Selective inhibitor of CK2. Also inhibits glutathione S-transferase | 476-66-4 |
| TBB | Selective cell-permeable CK2 inhibitor | 17374-26-4 |
| TBCA | Selective CK2 inhibitor | 934358-00-6 |
| TMCB | Dual-kinase inhibitor; inhibits CK2 and ERK8 | 905105-89-7 |
| TTP 22 | High affinity, selective CK2 inhibitor | 329907-28-0 |
(6) ApexBio Compounds for CSNK2A1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CX-4945 (Silmitasertib) | CK2 inhibitor | 1009820-21-6 |
| CX-4945 sodium salt | 1309357-15-0 | |
| DMAT | CK2 inhibitor,potent and selective | 749234-11-5 |
| Ellagic acid | Casein kinase 2 (CK2) inhibitor | 476-66-4 |
| TBB | Casein kinase-2 (CK2) inhibitor | 17374-26-4 |
| TTP 22 | CK2 inhibitor | 329907-28-0 |
Drug Products
- ApexBio compounds for CSNK2A1
Transcripts for CSNK2A1 Gene
mRNA/cDNA for CSNK2A1 Gene
- (3) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (419) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CSNK2A1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CSNK2A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSNK2A1
- GenScript: Design CRISPR guide RNA sequences for CSNK2A1
miRNA Products
- Search ViGene Biosciences for CSNK2A1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CSNK2A1
- Browse OriGene Inhibitory RNA Products For CSNK2A1
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK2A1 gene
Clone Products
- Sino Biological Human cDNA Clone for CSNK2A1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CSNK2A1
- VectorBuilder custom plasmid, inducible vectors for CSNK2A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK2A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12284) for CSNK2A1
Expression for CSNK2A1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
-
Placenta (Extraembryonic Tissues)
This gene is overexpressed in Fetal Brain (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSNK2A1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CSNK2A1 Gene:
CSNK2A1SOURCE GeneReport for Unigene cluster for CSNK2A1 Gene:
Hs.644056mRNA Expression by UniProt/SwissProt for CSNK2A1 Gene:
P68400-CSK21_HUMAN
Tissue specificity:
Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level).
Evidence on tissue expression from TISSUES for CSNK2A1 Gene
- Nervous system(4.7)
- Lung(4.6)
- Muscle(4.4)
- Kidney(2.6)
- Intestine(2.3)
- Liver(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CSNK2A1
-
OriGene qPCR primer pairs for CSNK2A1
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK2A1 Gene
Orthologs for CSNK2A1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| CSNK2A1 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | CSNK2A1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Csnk2a1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Csnk2a1 34 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | CSNK2A1 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CSNK2A1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100498392 34 |
|
||
| Str.714 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | ck2a1 34 35 |
|
||
| LOC100535532 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CkIIalpha 36 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005569 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | B0205.7 36 |
|
|
|
| kin-3 34 35 |
|
||||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F16467g 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADR204W 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CKA2 34 35 |
|
||
| CKA1 37 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT2G23070 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11074 35 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03124 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cka1 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.14189 34 |
|
- Species where no ortholog for CSNK2A1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CSNK2A1 Gene
(21) SIMAP similar genes for CSNK2A1 Gene using alignment to 7 proteins:
Variants for CSNK2A1 Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_077045 | Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062] | ||||
| VAR_077046 | Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062] | ||||
| VAR_077047 | Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062] | ||||
| VAR_077048 | Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062] | ||||
| rs869312840 | Pathogenic | 492,282(-) | CTTCA(A/G)AGGTC | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4221n100 | CNV | gain | 25217958 |
| dgv4222n100 | CNV | gain | 25217958 |
| esv2673541 | CNV | deletion | 23128226 |
| esv2674635 | CNV | deletion | 23128226 |
| esv3644952 | CNV | gain | 21293372 |
| esv3644953 | CNV | gain | 21293372 |
| nsv1056266 | CNV | gain | 25217958 |
| nsv1066598 | CNV | gain | 25217958 |
| nsv469833 | CNV | gain | 16826518 |
| nsv833891 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.29;
6.51% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CSNK2A1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK2A1 Gene
Disorders for CSNK2A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| okur-chung neurodevelopmental syndrome |
|
|
| cardiomyopathy, dilated, 1p |
|
|
| pachygyria |
|
|
Search CSNK2A1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CSK21_HUMAN- Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062]: An autosomal dominant neurodevelopmental disorder characterized by developmental delay, intellectual disability, behavioral problems, hypotonia, speech problems, microcephaly, pachygyria and variable dysmorphic features. {ECO:0000269 PubMed:27048600}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for CSNK2A1
No data available for Genatlas for CSNK2A1 Gene
Publications for CSNK2A1 Gene
- Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. (PMID: 1766873) Yang-Feng T.L. … Canaani D. (Nucleic Acids Res. 1991) 2 3 22 64
- Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. (PMID: 2174700) Lozeman F.J. … Krebs E.G. (Biochemistry 1990) 2 3 4 64
- CK2I+ phosphorylates DBC1 and is involved in the progression of gastric carcinoma and predicts poor survival of gastric carcinoma patients. (PMID: 24962073) Bae J.S. … Jang K.Y. (Int. J. Cancer 2015) 3 4 64
- The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. (PMID: 22406621) Rabellino A. … Scaglioni P.P. (Cancer Res. 2012) 3 4 64
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
Products for CSNK2A1 Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CSNK2A1
- EMD Millipore Purified and/or Recombinant CSNK2A1 Protein
- Browse Kits and Assays available from EMD Millipore
- EMD Millipore genomic analysis products
- R&D Systems Antibodies for CSNK2A1 (Casein Kinase 2 alpha)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CSNK2A1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CSNK2A1
- Search Origene for MassSpec and Protein Over-expression Lysates for CSNK2A1
- Origene Custom Protein Services for CSNK2A1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CSNK2A1
- Browse OriGene Inhibitory RNA Products For CSNK2A1
- OriGene qPCR primer pairs and template standards for CSNK2A1
- OriGene qPCR primer pairs for CSNK2A1
- OriGene CRISPR knockouts for CSNK2A1
- OriGene ORF clones in human for CSNK2A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CSNK2A1
- GenScript: Next-day shipping cDNA ORF clone for CSNK2A1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CSNK2A1
- GenScript Custom Assay Services for CSNK2A1
- GenScript Custom overexpressing Cell Line Services for CSNK2A1
- GenScript: Design CRISPR guide RNA sequences for CSNK2A1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CSNK2A1
- Cell Signaling Technology (CST) Antibodies for CSNK2A1 (CK2A1)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CSNK2A1
- Sino Biological Recombinant Proteins for CSNK2A1
- Sino Biological Cell Lysates for CSNK2A1
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CSNK2A1
- Novus Biologicals proteins and lysates for CSNK2A1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for CSNK2A1
- Taconic Biosciences Mouse Models for CSNK2A1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CSNK2A1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CSNK2A1
- Addgene plasmids for CSNK2A1
- antibodies-online Antibodies for CSNK2A1: See all 148
- antibodies-online Kits for CSNK2A1: See all 3
- antibodies-online Proteins for CSNK2A1: See all 23
- Search antibodies-online for peptides
- GeneTex CSNK2A1 antibody for CSNK2A1
- GeneTex Proteins for CSNK2A1
- ViGene Biosciences adenoviral particle packaged cDNA for CSNK2A1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CSNK2A1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CSNK2A1 gene
- Search ViGene Biosciences for CSNK2A1
- Santa Cruz Biotechnology (SCBT) Antibodies for CSNK2A1
- Search Santa Cruz Biotechnology (SCBT) for CSNK2A1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CSNK2A1
- Horizon Cell Lines for CSNK2A1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CSNK2A1
- VectorBuilder custom plasmid, inducible vectors for CSNK2A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK2A1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CSNK2A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
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- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (154) TISSUES
- (155) Gene ORGANizer