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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSNK2A1 Gene

protein-coding   GIFtS: 72
GCID: GC20M000459

Casein Kinase 2, Alpha 1 Polypeptide

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Casein Kinase 2, Alpha 1 Polypeptide1 2     Casein Kinase II Subunit Alpha2
CK2A12 3 5     CK II Alpha 32
EC 2.7.11.13 8     CK2 Catalytic Subunit Alpha2
CKII2     Protein Kinase CK22
CSNK2A32     CK II Alpha3
Casein Kinase II Alpha 1 Polypeptide Pseudogene2     EC 2.7.118
Casein Kinase II Alpha 1 Subunit2     

External Ids:    HGNC: 24571   Entrez Gene: 14572   Ensembl: ENSG000001012667   OMIM: 1154405   UniProtKB: P684003   

Export aliases for CSNK2A1 gene to outside databases

Previous GC identifers: GC20M000451 GC20M000458 GC20M000414


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSNK2A1 Gene:
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The
kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha
subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded
by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed
pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CSNK2A1 Gene: 
CSNK2A1 (casein kinase 2, alpha 1 polypeptide) is a protein-coding gene. Diseases associated with CSNK2A1 include globozoospermia, and bipolar i disorder, and among its related super-pathways are Wnt Signaling Pathway and Axon guidance. GO annotations related to this gene include beta-catenin binding and protein serine/threonine kinase activity. An important paralog of this gene is CSNK2A3.

UniProtKB/Swiss-Prot: CSK21_HUMAN, P68400
Function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates
a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as
viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an
appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle
assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also
required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can
also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3.
Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and
activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also
phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1,
SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential
for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts
as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates
various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at
'Ser-565' and primes it for ubiquitin-mediated degradation

summary for CSNK2A1 Gene:
Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase
that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2
functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha
and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are
catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the
alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins
implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought
to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the
phosphorylation of Akt.

Gene Wiki entry for CSNK2A1 (Casein kinase 2, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSNK2A1 gene promoter:
         TBP   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSNK2A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CSNK2A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

CSNK2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK2A1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M000459:  view genomic region     (about GC identifiers)

Start:
459,116 bp from pter      End:
524,482 bp from pter
Size:
65,367 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CSK21_HUMAN, P68400 (See protein sequence)
Recommended Name: Casein kinase II subunit alpha  
Size: 391 amino acids; 45144 Da
Subunit: Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory
subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha'/2 beta or 1 alpha/1
alpha'/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and
CSNK2B, which forms following UV irradiation. Interacts with RNPS1. Interacts with SNAI1. Interacts with PML
(isoform PML-12)
Miscellaneous: Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been
estimated to represent up to one quarter of the eukaryotic phosphoproteome. Casein kinase 2 has been found to be
increased at protein level and up-regulated at the level of enzyme activity in the majority of cancers. However,
elevated levels of casein kinase 2 are present in certain normal organs such as brain and testes
6/43 PDB 3D structures from and Proteopedia for CSNK2A1 (see all 43):
1JWH (3D)        1NA7 (3D)        1PJK (3D)        2PVR (3D)        2ZJW (3D)        3AMY (3D)    
Secondary accessions: B4DYS6 D3DVV8 P19138 P20426 Q14013 Q5U065
Alternative splicing: 2 isoforms:  P68400-1   P68400-2   

Explore the universe of human proteins at neXtProt for CSNK2A1: NX_P68400

Explore proteomics data for CSNK2A1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated
    during anaphase. Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its
    regulation by forming binding sites for interacting proteins and/or targeting it to different compartments
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P68400

  • 4/25 DME Specific Peptides for CSNK2A1 (P68400) (see all 25)
     REYWDYE  EVFEAIN  DNYDQLV  IAKVLGT 

    CSNK2A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CSNK2A1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001886.1  NP_808227.1  NP_808228.1  

    ENSEMBL proteins: 
     ENSP00000339247   ENSP00000217244   ENSP00000383086   ENSP00000383076  
    Reactome Protein details: P68400
    Human Recombinant Protein Products for CSNK2A1: 
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    Novus Biologicals CSNK2A1 Proteins
    Novus Biologicals CSNK2A1 Lysates
    Sino Biological Recombinant Protein for CSNK2A1
    Sino Biological Cell Lysate for CSNK2A1 
    ProSpec Recombinant Protein for CSNK2A1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS10799509
    GO:0016580Sin3 complex IDA17827154
    GO:0016581NuRD complex IDA17827154

    CSNK2A1 for ontologies           About GeneDecksing



    CSNK2A1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CSNK2A1
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    Cell Signaling Technology (CST) Antibodies for CSNK2A1  (CK2A1)
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    Abcam antibodies for CSNK2A1
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    ThermoFisher Antibody for CSNK2A1
    LSBio Antibodies in human, mouse, rat for CSNK2A1 

    Assay Products for CSNK2A1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CSNK2A1
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: casein kinase 2, alpha 1 polypeptide subunit 
    Selected non-AGC protein kinase activities
    Casein kinase 2 (CK2) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P68400

    ProtoNet protein and cluster: P68400

    UniProtKB/Swiss-Prot: CSK21_HUMAN, P68400
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily
    Similarity: Contains 1 protein kinase domain


    CSNK2A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSK21_HUMAN, P68400
    Function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates
    a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
    Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as
    viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an
    appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle
    assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also
    required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can
    also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3.
    Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and
    activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also
    phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1,
    SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential
    for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts
    as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates
    various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at
    'Ser-565' and primes it for ubiquitin-mediated degradation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Constitutively active protein kinase whose activity is not directly affected by
    phosphorylation. Seems to be regulated by level of expression and localization

         Genatlas biochemistry entry for CSNK2A1:
    casein kinase II,catalytic unit,alpha 1,ubiquitously expressed,likely involved in regulation of cell growth,also
    putative target and regulator of RaF/MAPK signaling,as a free CK2 beta (CSNK2B) form

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS2174700
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10094392
    GO:0005524ATP binding IEA--
         
    CSNK2A1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CSNK2A1:
     Decreased focal adhesion (FA)   Decreased telomerase activity  Gemcitabine induced cell-death  Increased circadian period len 
     Upregulation of Wnt/beta-caten 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Csnk2a1):
     cardiovascular system  craniofacial  embryogenesis  growth/size  hearing/vestibular/ear 
     limbs/digits/tail  mortality/aging  muscle  nervous system  vision/eye 

    CSNK2A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Csnk2a1tm1Dcs for CSNK2A1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CSNK2A1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSNK2A1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSNK2A1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSNK2A1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSNK2A1
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate CSNK2A1 (see all 53):
    hsa-miR-330-5p hsa-miR-1224-3p hsa-miR-200a hsa-miR-605 hsa-miR-548l hsa-miR-4275 hsa-miR-3161 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidCSNK2A1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
    Products:
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    Clone
    Products:
         
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    OriGene ORF clones in mouse, rat for CSNK2A1
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    GenScript: all cDNA clones in your preferred vector (see all 3): CSNK2A1 (NM_177559)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2A1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CSNK2A1 About   (see all 29)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Axon guidance
    Axon guidance0.69
    L1CAM interactions0.39
    Developmental Biology0.69
    Signal transduction by L10.32
    3M Phase
    M Phase0.88
    Mitotic M-M/G1 phases0.88
    4Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    5Translation Insulin regulation of translation
    Translation Regulation activity of EIF20.47
    Cell adhesion PLAU signaling0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for CSNK2A1
        Translation Regulation activity of EIF2
    Cell adhesion PLAU signaling
    DNA damage NHEJ mechanisms of DSBs repair

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSNK2A1
        NF-KappaB (p50-p65) Pathway
    GSK3 Signaling
    Erythropoietin Pathway

    2 Cell Signaling Technology (CST) Pathways for CSNK2A1
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 Tocris Bioscience Pathway for CSNK2A1
        NF-kappaB Pathway

    4 GeneGo (Thomson Reuters) Pathways for CSNK2A1
        Cell adhesion PLAU signaling
    DNA damage NHEJ mechanisms of DSBs repair
    Translation Regulation of EIF2 activity
    Regulation of CFTR activity (norm and CF)

    5/9 BioSystems Pathways for CSNK2A1 (see all 9)
        BDNF signaling pathway
    Wnt Signaling Pathway NetPath
    TNF-alpha/NF-kB Signaling Pathway
    BCR signaling pathway
    PDGFR-alpha signaling pathway

    1 Sino Biological Pathway for CSNK2A1 
        Non-Canonical Wnt Pathway

    5/10        Reactome Pathways for CSNK2A1 (see all 10)
        L1CAM interactions
    Developmental Biology
    Mitotic Prometaphase
    Cell Cycle
    M Phase


    5/8         Kegg Pathways  (Kegg details for CSNK2A1) (see all 8):
        Ribosome biogenesis in eukaryotes
    NF-kappa B signaling pathway
    Wnt signaling pathway
    Adherens junction
    Tight junction


    CSNK2A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSNK2A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/334 Interacting proteins for CSNK2A1 (P684001, 2, 3 ENSP000002172444) via UniProtKB, MINT, STRING, and/or I2D (see all 334)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224398P678701, 2, 3EBI-347804,EBI-348169 MINT-8206396 MINT-8206373 MINT-8206385 MINT-62785 MINT-62611 MINT-62709 I2D: score=15 
    ENSG00000230700P678701, 2, 3EBI-347804,EBI-348169 MINT-8206396 MINT-8206373 MINT-8206385 MINT-62785 MINT-62611 MINT-62709 I2D: score=15 
    ENSG00000224774P678701, 2, 3, ENSP000004156154EBI-347804,EBI-348169 MINT-8206396 MINT-8206373 MINT-8206385 MINT-62785 MINT-62611 MINT-62709 I2D: score=15 STRING: ENSP00000415615
    ENSG00000232960P678701, 2, 3, ENSP000003955464EBI-347804,EBI-348169 MINT-8206396 MINT-8206373 MINT-8206385 MINT-62785 MINT-62611 MINT-62709 I2D: score=15 STRING: ENSP00000395546
    ENSG00000206406P678701, 2, 3, ENSP000003829844EBI-347804,EBI-348169 MINT-8206396 MINT-8206373 MINT-8206385 MINT-62785 MINT-62611 MINT-62709 I2D: score=15 STRING: ENSP00000382984
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006468protein phosphorylation IDA--
    GO:0007165signal transduction TAS2174700

    CSNK2A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CSNK2A1 for compounds           About GeneDecksing

    EMD Millipore small molecules for CSNK2A1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CSNK2A1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TMCBDual-kinase inhibitor; inhibits CK2 and ERK8[905105-89-7]
    TBBSelective cell-permeable CK2 inhibitor[17374-26-4]
    TTP 22 High affinity, selective CK2 inhibitor [329907-28-0]
    Ellagic acidSelective inhibitor of CK2. Also inhibits glutathione S-transferase[476-66-4]

    2 HMDB Compounds for CSNK2A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10/24 DrugBank Compounds for CSNK2A1 (see all 24)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzamidine-- 618-39-3target--17139284 17016423 10592235
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423 10592235
    Tetrabromo-2-Benzotriazole-- --target--17139284 17016423 10592235
    Ellagic Acid-- 476-66-4targetinhibitor16610779 19414254
    (5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid-- --target--10592235
    1,2,5,8-tetrahydroxyanthracene-9,10-dione-- --target--10592235
    1,8-Di-Hydroxy-4-Nitro-Anthraquinone-- --target--10592235
    1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One-- --target--10592235
    19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one-- --target--10592235
    2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione-- --target--10592235

    10/65 Novoseek inferred chemical compound relationships for CSNK2A1 gene (see all 65)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4,5,6,7-tetrabromobenzotriazole 93.2 11 11988074 (2), 18548199 (1), 16687488 (1), 12869192 (1) (see all 5)
    dmat 83.1 2 20383646 (1), 19424641 (1)
    5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 77.3 10 18556661 (1), 20026644 (1), 11593402 (1), 12748192 (1) (see all 9)
    threonine 76.4 67 12748192 (2), 1590772 (1), 8529132 (1), 8943850 (1) (see all 64)
    serine 75.2 101 10448092 (3), 8384219 (2), 1425701 (2), 15823605 (2) (see all 87)
    apigenin 64.5 5 11673497 (1), 15302569 (1), 16520553 (1), 16442104 (1) (see all 5)
    5,6-dichlorobenzimidazole riboside 63.8 2 8765099 (1), 19043076 (1)
    gtp 55.4 17 8049218 (1), 7735321 (1), 10197447 (1), 10398759 (1) (see all 14)
    phosphocellulose 54.8 6 8696255 (1), 9143340 (1), 2040287 (1), 1835512 (1)
    glycyrrhetinic acid 53.5 2 9654140 (1), 10443459 (1)

    Search CenterWatch for drugs/clinical trials and news about CSNK2A1 / CSK21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CSNK2A1 gene (3 alternative transcripts): 
    NM_001895.3  NM_177559.2  NM_177560.2  

    Unigene Cluster for CSNK2A1:

    Casein kinase 2, alpha 1 polypeptide
    Hs.644056  [show with all ESTs]
    Unigene Representative Sequence: NM_177559
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000349736(uc002wdx.1) ENST00000217244(uc002wdw.1) ENST00000460062
    ENST00000400227 ENST00000400217(uc002wdy.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB451279.1 AB451411.1 AK302583.1 AK312535.1 AY735339.1 BC002615.2 BC011668.2 BC050036.1 
    BC053532.1 BC071167.1 BT019792.1 DQ354583.1 J02853.1 M55265.1 S53149.1 

    22 DOTS entries:

    DT.99935781  DT.456148  DT.100821389  DT.100821391  DT.101957241  DT.100821379  DT.100821384  DT.97855916 
    DT.100707032  DT.91745722  DT.100821387  DT.95258504  DT.100739418  DT.120821869  DT.120821893  DT.120821992 
    DT.40245765  DT.92445999  DT.100821390  DT.120821972  DT.95258004  DT.99936596 

    24/419 AceView cDNA sequences (see all 419):

    AW963200 BE326800 BU622644 BU742389 AA954443 AI589577 AW014368 AA741161 
    CA944553 BM932226 AU132296 BM675522 AA713580 AA948280 T81653 BE677579 
    BE550309 BM683364 BG149299 AL601215 AI202077 BM785307 AI674053 BM452475 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSNK2A1 expression in normal human tissues (normalized intensities)      CSNK2A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCATCCAGTG
    CSNK2A1 Expression
    About this image


    CSNK2A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Eye (Sensory Organs)
             Retina

    See CSNK2A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSNK2A1

    SOURCE GeneReport for Unigene cluster: Hs.644056
        SABiosciences Expression via Pathway-Focused PCR Arrays including CSNK2A1 (see all 7): 
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Circadian Rhythms in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSNK2A1 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csnk2a11 , 5 casein kinase 2, alpha 1 polypeptide1, 5 94.54(n)1
    98.72(a)1
      2 (74.83 cM)5
    129951  NM_007788.31  NP_031814.21 
     1522268395 
    chicken
    (Gallus gallus)
    Aves CSNK2A11 casein kinase 2, alpha 1 polypeptide 86.87(n)
    97.95(a)
      432370  NM_001002242.1  NP_001002242.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSNK2A16
    --
    Uncharacterized protein
    96(a)
    90(a)
    many → 1
    possible ortholog
    GL343346.1(62790-83370)
    1(259625956-259653886)
    African clawed frog
    (Xenopus laevis)
    Amphibia X62375.22   -- 79.97(n)    X62375.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ck2a12 casein kinase 2 alpha 1 80.71(n)   30502  BC044403.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CkIIalpha1 , 3 frizzled receptor signaling pathway
    protein kinase3
    Casein kinase II alpha subunit1
    88(a)3
    73.39(n)1
    88.69(a)1
      80D23
    484481  NM_080179.41  NP_524918.11 
    worm
    (Caenorhabditis elegans)
    Secernentea B0205.73
    kin-31
    casein kinase3
    Protein KIN-31
    83(a)3
    69.11(n)1
    78.59(a)1
      I(10742092-10744293)3
    1729781  NM_060410.31  NP_492811.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CKA1(YIL035C)4
    CKA21
    Alpha catalytic subunit of casein kinase 2 (CK2), a more4
    Cka2p1
    57.41(n)1
    59.88(a)1
      9(288908-287790)4
    8542271  NP_014704.11  8547764 
     NP_012229.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CKA21 casein kinase II, alpha chain 2 67.18(n)
    75.23(a)
      824162  NM_114860.3  NP_190569.2 
    rice
    (Oryza sativa)
    Liliopsida Os07g01144001 hypothetical protein 67.38(n)
    77.2(a)
      4342248  NM_001065287.1  NP_001058752.1 


    ENSEMBL Gene Tree for CSNK2A1 (if available)
    TreeFam Gene Tree for CSNK2A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSNK2A1 gene
    CSNK2A32  CSNK2A22  
    18/21 SIMAP similar genes for CSNK2A1 using alignment to 4 protein entries:     CSK21_HUMAN (see all proteins) (see all similar genes):
    CSNK2A3    CSNK2A2    RPS6KA2    CDK3    CDK2    MAPK3
    CDK1    NUAK1    STK11    CCRK    CDK4    DKFZp686O0215
    CDK5    DKFZp686L20222    MAPK1    MAPK13    CDKL4    MAPK14

    CSNK2A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1341 SNPs in CSNK2A1 are shown (see all 1341)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1896797671,2
    --411253(+) AGAGCC/TGATGG 3 -- ds50010--------
    rs1141478901,2
    F--411328(+) GATTAC/GAGTGG 3 -- ds50011Minor allele frequency- G:0.02WA 118
    rs785365371,2
    F--411344(+) CCACTT/CTACAC 3 -- ds50011Minor allele frequency- C:0.01EA 120
    rs1927057071,2
    --411417(+) ACAAAA/GTGAGT 3 -- ds50010--------
    rs1850076311,2
    --411418(+) CAAAAA/TGAGTT 3 -- ds50010--------
    rs61393141,2
    C,H--411439(+) GGATCC/TTTAAT 3 -- ds50016Minor allele frequency- T:0.00NS EA NA 402
    rs2001732811,2
    --411472(+) GGTGC-/TTTTTT 3 -- ds50010--------
    rs61393151,2
    H--411540(+) GGGGCC/TTTGGG 3 -- ds50014Minor allele frequency- T:0.00NS EA 406
    rs750324381,2
    C,F--411572(+) GCAGGC/ACCCTC 3 -- ds50011Minor allele frequency- A:0.09WA 118
    rs1882340781,2
    --411686(+) ACACTA/GGATCT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CSNK2A1 (459116 - 524482 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CSNK2A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673541CNV Deletion23128226
    esv2674635CNV Deletion23128226
    nsv469833CNV Gain16826518
    dgv4509n71CNV Gain21882294
    nsv833891CNV Gain+Loss17160897


    Locus Specific Mutation Databases (LSDB): CSNK2A1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 115440    OMIM disorders: --

    20/49 diseases for CSNK2A1 (see all 49):    About MalaCards
    globozoospermia    bipolar i disorder    adrenocortical carcinoma    schizoaffective disorder
    squamous cell carcinoma of the head and neck    laryngitis    laryngeal carcinoma    vaccinia
    laryngeal squamous cell carcinoma    lissencephaly    malaria    lupus nephritis
    gout    measles    wilms tumor    nephritis
    squamous cell carcinoma    nasopharyngitis    endometrial carcinoma    colon cancer


    CSNK2A1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/26 Novoseek inferred disease relationships for CSNK2A1 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal neovascularization 29.9 3 15557471 (1), 18612802 (1), 16651637 (1)
    cancer 27.2 25 19387548 (2), 14965269 (2), 9820486 (1), 12149649 (1) (see all 22)
    prostate carcinoma 25.5 2 12738992 (1), 16687488 (1)
    mammary tumor 22.8 1 17575143 (1)
    tumors 17.1 20 8037705 (2), 12479100 (1), 9042966 (1), 10862016 (1) (see all 19)
    prostate cancer 8.98 7 17044081 (2), 12738992 (1), 16489027 (1), 18574673 (1) (see all 6)
    metastasis 2.81 1 18062282 (1)
    carcinoma 2.33 1 10533285 (1)
    t-all 1.49 1 8895560 (1)
    astrocytoma 0 1 16520553 (1)

    Genetic Association Database (GAD): CSNK2A1
    Human Genome Epidemiology (HuGE) Navigator: CSNK2A1 (8 documents)

    Export disorders for CSNK2A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSNK2A1 gene, integrated from 9 sources (see all 839):
    (articles sorted by number of sources associating them with CSNK2A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. (PubMed id 2174700)1, 2, 3 Lozeman F.J....Krebs E.G. (1990)
    2. Protein kinase CK2 in health and disease: CK2: the ki nase controlling the Hsp90 chaperone machinery. (PubMed id 19387550)1, 2, 9 Miyata Y. (2009)
    3. Mapping of the human casein kinase II catalytic subun it genes: two loci carrying the homologous sequences for the alpha subunit. (PubMed id 1766873)1, 3, 9 Yang-Feng T.L....Canaani D. (1991)
    4. The SUMO E3-ligase PIAS1 regulates the tumor suppresso r PML and its oncogenic counterpart PML-RARA. (PubMed id 22406621)1, 2 Rabellino A....Scaglioni P.P. (2012)
    5. Phosphorylation of serine 11 and serine 92 as new pos itive regulators of human Snail1 function: potential involvement of casein kina se-2 and the cAMP-activated kinase protein kinase A. (PubMed id 19923321)1, 2 MacPherson M.R....Cano A. (2010)
    6. Functional polymorphism of the CK2alpha intronless ge ne plays oncogenic roles in lung cancer. (PubMed id 20625391)1, 2 Hung M.S....You L. (2010)
    7. Genome-wide association study for colorectal cancer i dentifies risk polymorphisms in German familial cases and implicates MAPK signa lling pathways in disease susceptibility. (PubMed id 20610541)1, 4 Lascorz J....Hemminki K. (2010)
    8. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (PubMed id 19839995)1, 4 Mansour H.A....Nimgaonkar V.L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1457 HGNC: 2457 AceView: CSNK2A1 Ensembl:ENSG00000101266 euGenes: HUgn1457
    ECgene: CSNK2A1 Kegg: 1457 H-InvDB: CSNK2A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSNK2A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CSNK2A1 gene:
    Search GeneIP for patents involving CSNK2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for CSNK2A1
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     Abcam protocols and scientific support
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     Browse Proteins at Cloud-Clone Corp.
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     Search LifeMap BioReagents cell lines for CSNK2A1
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2A1
     SwitchGear 3'UTR luciferase reporter plasmids for CSNK2A1
     SwitchGear Promoter luciferase reporter plasmids for CSNK2A1
     ThermoFisher Antibody for CSNK2A1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK2A1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CSNK2A1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSNK2A1
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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