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Aliases for CSNK2A1 Gene

Aliases for CSNK2A1 Gene

  • Casein Kinase 2 Alpha 1 2 3 5
  • Casein Kinase 2, Alpha 1 Polypeptide 2 3
  • EC 2.7.11.1 4 61
  • CK2A1 3 4
  • Casein Kinase II Alpha 1 Polypeptide Pseudogene 3
  • Casein Kinase II Alpha 1 Subunit 3
  • Casein Kinase II Subunit Alpha 3
  • CK2 Catalytic Subunit Alpha 3
  • Protein Kinase CK2 3
  • CK II Alpha 3 3
  • CK II Alpha 4
  • EC 2.7.11 61
  • CSNK2A3 3
  • OCNDS 3
  • CKII 3

External Ids for CSNK2A1 Gene

Previous GeneCards Identifiers for CSNK2A1 Gene

  • GC20M000451
  • GC20M000458
  • GC20M000414

Summaries for CSNK2A1 Gene

Entrez Gene Summary for CSNK2A1 Gene

  • Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for CSNK2A1 Gene

CSNK2A1 (Casein Kinase 2 Alpha 1) is a Protein Coding gene. Diseases associated with CSNK2A1 include Okur-Chung Neurodevelopmental Syndrome and Cardiomyopathy, Dilated, 1P. Among its related pathways are Regulation of TP53 Activity and DNA damage_NHEJ mechanisms of DSBs repair. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK2A3.

UniProtKB/Swiss-Prot for CSNK2A1 Gene

  • Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating Ser-392 of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at Ser-565 and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at Ser-90 which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at Thr-454 in gastric carcinoma tissue (PubMed:24962073).

Tocris Summary for CSNK2A1 Gene

  • Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase thought to have a regulatory function in cell proliferation, differentiation and apoptosis. CK2 functions as a tetrameric complex with 2 regulatory and 2 catalytic subunits.

Gene Wiki entry for CSNK2A1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK2A1 Gene

Genomics for CSNK2A1 Gene

Regulatory Elements for CSNK2A1 Gene

Enhancers for CSNK2A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G000368 2 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +171.3 171318 8.0 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 TBC1D20 TRIB3 RBCK1 SRXN1 ENSG00000206797 CSNK2A1 FAM110A GC20P000387 GC20P000385
GH20G000645 1.6 Ensembl ENCODE dbSUPER 12.1 -102.4 -102385 2.3 FOXA2 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143 SRXN1 TCF15 CSNK2A1 SCRT2 SLC52A3 GC20M000621 GC20M000631
GH20G000571 1.4 Ensembl ENCODE dbSUPER 12.6 -29.5 -29525 3.9 HDAC1 ATF1 KLF17 ARID4B FEZF1 ZNF335 TCF12 EGR1 SCRT2 CREM CSNK2A1 TCF15 GC20M000594
GH20G000360 1.7 Ensembl ENCODE dbSUPER 10.3 +179.9 179909 7.8 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 TBC1D20 RBCK1 ACTG1P3 ENSG00000206797 CSNK2A1 C20orf96 SLC52A3 TRIB3 GC20P000387 GC20P000385
GH20G000727 1.5 Ensembl ENCODE dbSUPER 11.2 -184.6 -184647 1.3 ATF1 ARID4B ZNF48 GLIS2 CBX5 ZNF143 ZNF263 SP5 MIER2 REST SCRT2 SRXN1 SLC52A3 CSNK2A1 ANGPT4 SOX12 GC20P000743 PIR59185
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CSNK2A1 on UCSC Golden Path with GeneCards custom track

Promoters for CSNK2A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133443 538 1801 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Transcription factor binding sites by QIAGEN in the CSNK2A1 gene promoter:

Genomic Location for CSNK2A1 Gene

Chromosome:
20
Start:
472,969 bp from pter
End:
543,838 bp from pter
Size:
70,870 bases
Orientation:
Minus strand

Genomic View for CSNK2A1 Gene

Genes around CSNK2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK2A1 Gene

Proteins for CSNK2A1 Gene

  • Protein details for CSNK2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68400-CSK21_HUMAN
    Recommended name:
    Casein kinase II subunit alpha
    Protein Accession:
    P68400
    Secondary Accessions:
    • B4DYS6
    • D3DVV8
    • P19138
    • P20426
    • Q14013
    • Q5U065

    Protein attributes for CSNK2A1 Gene

    Size:
    391 amino acids
    Molecular mass:
    45144 Da
    Quaternary structure:
    • Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha/2 beta or 1 alpha/1 alpha/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation. Interacts with RNPS1. Interacts with SNAI1. Interacts with PML (isoform PML-12). Interacts with CCAR2.
    Miscellaneous:
    • Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome. Casein kinase 2 has been found to be increased at protein level and up-regulated at the level of enzyme activity in the majority of cancers. However, elevated levels of casein kinase 2 are present in certain normal organs such as brain and testes.

    Three dimensional structures from OCA and Proteopedia for CSNK2A1 Gene

    Alternative splice isoforms for CSNK2A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSNK2A1 Gene

Selected DME Specific Peptides for CSNK2A1 Gene

P68400:
  • RHSRKRWERFVHS
  • LDKLLRYDHQ
  • NQHLVSPEA
  • LIDWGLAE
  • GIMHRDVKPHNVMID
  • EAMEHPYFY
  • LKALDYCHS
  • GRGKYSEVF
  • REYWDYE
  • DNYDQLV
  • MPGGSTPVSSA
  • LDPRFNDILGRHSRKRWERF
  • MIFRKEPFF
  • KILENLRGG
  • DIRFYMYE
  • YQLVRKL
  • YNVRVASR
  • EVFEAIN
  • IAKVLGT
  • KKKIKRE
  • SPEALDFL
  • YDYSLDMWSLGC
  • MLASMIF
  • PFFHGHDN
  • TPALVFE

Post-translational modifications for CSNK2A1 Gene

  • Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase. Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its regulation by forming binding sites for interacting proteins and/or targeting it to different compartments.
  • Ubiquitination at Lys229
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CSNK2A1 (Casein Kinase 2 alpha)
  • Cell Signaling Technology (CST) Antibodies for CSNK2A1 (CK2A1)

Domains & Families for CSNK2A1 Gene

Protein Domains for CSNK2A1 Gene

Graphical View of Domain Structure for InterPro Entry

P68400

UniProtKB/Swiss-Prot:

CSK21_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
genes like me logo Genes that share domains with CSNK2A1: view

Function for CSNK2A1 Gene

Molecular function for CSNK2A1 Gene

GENATLAS Biochemistry:
casein kinase II,catalytic unit,alpha 1,ubiquitously expressed,likely involved in regulation of cell growth,also putative target and regulator of RaF/MAPK signaling,as a free CK2 beta (CSNK2B) form
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating Ser-392 of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at Ser-565 and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at Ser-90 which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at Thr-454 in gastric carcinoma tissue (PubMed:24962073).

Enzyme Numbers (IUBMB) for CSNK2A1 Gene

Gene Ontology (GO) - Molecular Function for CSNK2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IMP,TAS 2174700
GO:0005515 protein binding IPI 10094392
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IDA 18548200
genes like me logo Genes that share ontologies with CSNK2A1: view
genes like me logo Genes that share phenotypes with CSNK2A1: view

Animal Models for CSNK2A1 Gene

MGI Knock Outs for CSNK2A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CSNK2A1

miRNA for CSNK2A1 Gene

miRTarBase miRNAs that target CSNK2A1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK2A1 Gene

Localization for CSNK2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK2A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK2A1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CSNK2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 21282530
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS 10799509
GO:0005956 protein kinase CK2 complex IDA 15723517
genes like me logo Genes that share ontologies with CSNK2A1: view

Pathways & Interactions for CSNK2A1 Gene

genes like me logo Genes that share pathways with CSNK2A1: view

Gene Ontology (GO) - Biological Process for CSNK2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006457 protein folding TAS --
GO:0006468 protein phosphorylation IDA,IEA 18548200
GO:0006656 phosphatidylcholine biosynthetic process TAS --
genes like me logo Genes that share ontologies with CSNK2A1: view

Drugs & Compounds for CSNK2A1 Gene

(65) Drugs for CSNK2A1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Resveratrol Experimental, Investigational Pharma Target Wee1 kinase inhibtor,potent and ATP-competitive, Others, Cyclooxygenase inhibitor 122
(5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid Experimental Pharma Target 0
1,2,5,8-tetrahydroxyanthracene-9,10-dione Experimental Pharma Target 0
1,8-Di-Hydroxy-4-Nitro-Anthraquinone Experimental Pharma Target 0

(31) Additional Compounds for CSNK2A1 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
TBCA
934358-00-6

(5) Tocris Compounds for CSNK2A1 Gene

Compound Action Cas Number
Ellagic acid Selective inhibitor of CK2. Also inhibits glutathione S-transferase 476-66-4
TBB Selective cell-permeable CK2 inhibitor 17374-26-4
TBCA Selective CK2 inhibitor 934358-00-6
TMCB Dual-kinase inhibitor; inhibits CK2 and ERK8 905105-89-7
TTP 22 High affinity, selective CK2 inhibitor 329907-28-0

(6) ApexBio Compounds for CSNK2A1 Gene

Compound Action Cas Number
CX-4945 (Silmitasertib) CK2 inhibitor 1009820-21-6
CX-4945 sodium salt 1309357-15-0
DMAT CK2 inhibitor,potent and selective 749234-11-5
Ellagic acid Casein kinase 2 (CK2) inhibitor 476-66-4
TBB Casein kinase-2 (CK2) inhibitor 17374-26-4
TTP 22 CK2 inhibitor 329907-28-0
genes like me logo Genes that share compounds with CSNK2A1: view

Drug Products

Transcripts for CSNK2A1 Gene

Unigene Clusters for CSNK2A1 Gene

Casein kinase 2, alpha 1 polypeptide:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK2A1 Gene

No ASD Table

Relevant External Links for CSNK2A1 Gene

GeneLoc Exon Structure for
CSNK2A1
ECgene alternative splicing isoforms for
CSNK2A1

Expression for CSNK2A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSNK2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSNK2A1 Gene

This gene is overexpressed in Fetal Brain (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSNK2A1 Gene



Protein tissue co-expression partners for CSNK2A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CSNK2A1 Gene:

CSNK2A1

SOURCE GeneReport for Unigene cluster for CSNK2A1 Gene:

Hs.644056

mRNA Expression by UniProt/SwissProt for CSNK2A1 Gene:

P68400-CSK21_HUMAN
Tissue specificity: Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level).

Evidence on tissue expression from TISSUES for CSNK2A1 Gene

  • Nervous system(4.7)
  • Lung(4.6)
  • Muscle(4.4)
  • Kidney(2.6)
  • Intestine(2.3)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with CSNK2A1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK2A1 Gene

Orthologs for CSNK2A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK2A1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 100 (a)
OneToMany
CSNK2A1 34
  • 96.76 (n)
cow
(Bos Taurus)
Mammalia CSNK2A1 34 35
  • 96.5 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Csnk2a1 34 16 35
  • 94.54 (n)
rat
(Rattus norvegicus)
Mammalia Csnk2a1 34
  • 93.86 (n)
chimpanzee
(Pan troglodytes)
Mammalia CSNK2A1 34
  • 93.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves CSNK2A1 34 35
  • 86.87 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 95 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498392 34
  • 79.26 (n)
Str.714 34
zebrafish
(Danio rerio)
Actinopterygii ck2a1 34 35
  • 87 (a)
LOC100535532 34
  • 73.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta CkIIalpha 36 34 35
  • 73.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005569 34
  • 69.31 (n)
worm
(Caenorhabditis elegans)
Secernentea B0205.7 36
  • 83 (a)
kin-3 34 35
  • 69.11 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16467g 34
  • 59.52 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR204W 34
  • 59.01 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKA2 34 35
  • 57.41 (n)
CKA1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G23070 34
  • 69.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11074 35
  • 86 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03124 34
  • 66.14 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cka1 34
  • 62.95 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14189 34
Species where no ortholog for CSNK2A1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK2A1 Gene

ENSEMBL:
Gene Tree for CSNK2A1 (if available)
TreeFam:
Gene Tree for CSNK2A1 (if available)

Paralogs for CSNK2A1 Gene

Paralogs for CSNK2A1 Gene

genes like me logo Genes that share paralogs with CSNK2A1: view

Variants for CSNK2A1 Gene

Sequence variations from dbSNP and Humsavar for CSNK2A1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_077045 Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062]
VAR_077046 Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062]
VAR_077047 Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062]
VAR_077048 Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062]
rs869312840 Pathogenic 492,282(-) CTTCA(A/G)AGGTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CSNK2A1 Gene

Variant ID Type Subtype PubMed ID
dgv4221n100 CNV gain 25217958
dgv4222n100 CNV gain 25217958
esv2673541 CNV deletion 23128226
esv2674635 CNV deletion 23128226
esv3644952 CNV gain 21293372
esv3644953 CNV gain 21293372
nsv1056266 CNV gain 25217958
nsv1066598 CNV gain 25217958
nsv469833 CNV gain 16826518
nsv833891 CNV gain+loss 17160897

Variation tolerance for CSNK2A1 Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK2A1 Gene

Human Gene Mutation Database (HGMD)
CSNK2A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK2A1 Gene

Disorders for CSNK2A1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CSNK2A1 Gene - From: ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
okur-chung neurodevelopmental syndrome
  • ocnds
cardiomyopathy, dilated, 1p
  • dilated cardiomyopathy 1p
pachygyria
  • broad gyri of cerebrum
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CSK21_HUMAN
  • Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062]: An autosomal dominant neurodevelopmental disorder characterized by developmental delay, intellectual disability, behavioral problems, hypotonia, speech problems, microcephaly, pachygyria and variable dysmorphic features. {ECO:0000269 PubMed:27048600}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CSNK2A1

Genetic Association Database (GAD)
CSNK2A1
Human Genome Epidemiology (HuGE) Navigator
CSNK2A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK2A1
genes like me logo Genes that share disorders with CSNK2A1: view

No data available for Genatlas for CSNK2A1 Gene

Publications for CSNK2A1 Gene

  1. Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. (PMID: 1766873) Yang-Feng T.L. … Canaani D. (Nucleic Acids Res. 1991) 2 3 22 64
  2. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. (PMID: 2174700) Lozeman F.J. … Krebs E.G. (Biochemistry 1990) 2 3 4 64
  3. CK2I+ phosphorylates DBC1 and is involved in the progression of gastric carcinoma and predicts poor survival of gastric carcinoma patients. (PMID: 24962073) Bae J.S. … Jang K.Y. (Int. J. Cancer 2015) 3 4 64
  4. The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. (PMID: 22406621) Rabellino A. … Scaglioni P.P. (Cancer Res. 2012) 3 4 64
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64

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