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CSNK2A1 Gene

protein-coding   GIFtS: 73
GCID: GC20M000459

Casein Kinase 2, Alpha 1 Polypeptide

  See CSNK2A1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Casein Kinase 2, Alpha 1 Polypeptide1 2     Casein Kinase II Subunit Alpha2
CK2A12 3 5     CK II Alpha 32
EC 2.7.11.13 8     CK2 Catalytic Subunit Alpha2
CKII2     Protein Kinase CK22
CSNK2A32     CK II Alpha3
Casein Kinase II Alpha 1 Polypeptide Pseudogene2     EC 2.7.118
Casein Kinase II Alpha 1 Subunit2     

External Ids:    HGNC: 24571   Entrez Gene: 14572   Ensembl: ENSG000001012667   OMIM: 1154405   UniProtKB: P684003   

Export aliases for CSNK2A1 gene to outside databases

Previous GC identifers: GC20M000451 GC20M000458 GC20M000414


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSNK2A1 Gene:
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is
involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The
kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha
subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded
by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed
pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found
for this gene. (provided by RefSeq, Feb 2014)

GeneCards Summary for CSNK2A1 Gene:
CSNK2A1 (casein kinase 2, alpha 1 polypeptide) is a protein-coding gene. Diseases associated with CSNK2A1 include globozoospermia. GO annotations related to this gene include beta-catenin binding and protein serine/threonine kinase activity. An important paralog of this gene is CSNK2A3.

UniProtKB/Swiss-Prot: CSK21_HUMAN, P68400
Function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates
a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as
viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an
appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle
assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also
required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can
also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3.
Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and
activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also
phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1,
SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential
for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts
as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates
various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at
'Ser-565' and primes it for ubiquitin-mediated degradation

summary for CSNK2A1 Gene:
Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase
that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2
functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha
and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are
catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the
alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins
implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought
to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the
phosphorylation of Akt.

Gene Wiki entry for CSNK2A1 (Casein kinase 2, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSNK2A1 gene promoter:
         TBP   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSNK2A1 promoter sequence
   Search Chromatin IP Primers for CSNK2A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSNK2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

CSNK2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK2A1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M000459:  view genomic region     (about GC identifiers)

Start:
459,116 bp from pter      End:
524,482 bp from pter
Size:
65,367 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CSK21_HUMAN, P68400 (See protein sequence)
Recommended Name: Casein kinase II subunit alpha  
Size: 391 amino acids; 45144 Da
Subunit: Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory
subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha'/2 beta or 1 alpha/1
alpha'/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and
CSNK2B, which forms following UV irradiation. Interacts with RNPS1. Interacts with SNAI1. Interacts with PML
(isoform PML-12)
Miscellaneous: Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been
estimated to represent up to one quarter of the eukaryotic phosphoproteome. Casein kinase 2 has been found to be
increased at protein level and up-regulated at the level of enzyme activity in the majority of cancers. However,
elevated levels of casein kinase 2 are present in certain normal organs such as brain and testes
Selected PDB 3D structures from and Proteopedia for CSNK2A1 (see all 50):
1JWH (3D)        1NA7 (3D)        1PJK (3D)        2PVR (3D)        2ZJW (3D)        3AMY (3D)    
Secondary accessions: B4DYS6 D3DVV8 P19138 P20426 Q14013 Q5U065
Alternative splicing: 2 isoforms:  P68400-1   P68400-2   

Explore the universe of human proteins at neXtProt for CSNK2A1: NX_P68400

Explore proteomics data for CSNK2A1 at MOPED

Post-translational modifications: 

  • Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated
    during anaphase. Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its
    regulation by forming binding sites for interacting proteins and/or targeting it to different compartments1
  • Ubiquitination2 at Lys83, Lys102, Lys122, Lys229, Lys303, Lys329
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CSNK2A1 (P68400) (see all 25)
     REYWDYE  EVFEAIN  DNYDQLV  IAKVLGT 


    See CSNK2A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001886.1  NP_808227.1  NP_808228.1  

    ENSEMBL proteins: 
     ENSP00000339247   ENSP00000217244   ENSP00000383076   ENSP00000477147   ENSP00000476486  
     ENSP00000476547   ENSP00000383086  
    Reactome Protein details: P68400

    CSNK2A1 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CSNK2A1
    Sino Biological Cell Lysate for CSNK2A1
    ProSpec Recombinant Protein for CSNK2A1
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CSNK2A1 (13 products) 

     
    antibodies-online peptides for CSNK2A1

    CSNK2A1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CSNK2A1
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    Novus Biologicals CSNK2A1 Antibodies
    Abcam antibodies for CSNK2A1
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    antibodies-online antibodies for CSNK2A1 (109 products) 

    CSNK2A1 Assay Products:

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    antibodies-online kits for CSNK2A1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: casein kinase 2, alpha 1 polypeptide subunit
    Selected non-AGC protein kinase activities
    Casein kinase 2 (CK2) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P68400

    ProtoNet protein and cluster: P68400

    UniProtKB/Swiss-Prot: CSK21_HUMAN, P68400
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CSNK2A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSK21_HUMAN, P68400
    Function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates
    a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
    Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as
    viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an
    appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle
    assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also
    required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can
    also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3.
    Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and
    activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also
    phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1,
    SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential
    for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts
    as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates
    various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at
    'Ser-565' and primes it for ubiquitin-mediated degradation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Constitutively active protein kinase whose activity is not directly affected by
    phosphorylation. Seems to be regulated by level of expression and localization

         Genatlas biochemistry entry for CSNK2A1:
    casein kinase II,catalytic unit,alpha 1,ubiquitously expressed,likely involved in regulation of cell growth,also
    putative target and regulator of RaF/MAPK signaling,as a free CK2 beta (CSNK2B) form

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS2174700
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10094392
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CSNK2A1           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for CSNK2A1:
     Decreased focal adhesion (FA)   Decreased telomerase activity  Gemcitabine induced cell-death  Increased circadian period len 
     Upregulation of Wnt/beta-caten 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Csnk2a1):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  hearing/vestibular/ear 
     limbs/digits/tail  mortality/aging  muscle  nervous system  pigmentation 
     vision/eye 

    Find genes that share phenotypes with CSNK2A1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Csnk2a1tm1Dcs for CSNK2A1

       genOway: Develop your customized and physiologically relevant rodent model for CSNK2A1

    miRNA
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    miRTarBase miRNAs that target CSNK2A1:
    hsa-mir-183-5p (MIRT047136), hsa-let-7a-5p (MIRT052591), hsa-let-7c-5p (MIRT051854), hsa-mir-10a-5p (MIRT047540), hsa-let-7b-5p (MIRT052272), hsa-mir-337-3p (MIRT007208), hsa-mir-216b-5p (MIRT007207), hsa-mir-615-3p (MIRT039801), hsa-mir-10b-5p (MIRT047431), hsa-mir-652-3p (MIRT039530), hsa-mir-760 (MIRT007209), hsa-mir-186-5p (MIRT007210), hsa-mir-22-3p (MIRT030638)

    Block miRNA regulation of human, mouse, rat CSNK2A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSNK2A1 (see all 53):
    hsa-miR-330-5p hsa-miR-1224-3p hsa-miR-200a hsa-miR-605 hsa-miR-548l hsa-miR-4275 hsa-miR-3161 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidCSNK2A1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSNK2A1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    plasma membrane4
    cytoskeleton2
    chloroplast1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS10799509
    GO:0016580Sin3 complex IDA17827154
    GO:0016581NuRD complex IDA17827154

    Find genes that share ontologies with CSNK2A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSNK2A1 About   (see all 28)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    4Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Condensation of Prometaphase Chromosomes0.00
    5Translation Insulin regulation of translation
    Translation Regulation activity of EIF20.47
    Cell adhesion PLAU signaling0.35


    Find genes that share SuperPaths with CSNK2A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CSNK2A1
        NF-KappaB (p50-p65) Pathway
    GSK3 Signaling
    Erythropoietin Pathway

    2 Cell Signaling Technology (CST) Pathways for CSNK2A1
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 Tocris Bioscience Pathway for CSNK2A1
        NF-kappaB Pathway

    4 GeneGo (Thomson Reuters) Pathways for CSNK2A1
        Cell adhesion PLAU signaling
    DNA damage NHEJ mechanisms of DSBs repair
    Translation Regulation of EIF2 activity
    Regulation of CFTR activity (norm and CF)

    Selected BioSystems Pathways for CSNK2A1 (see all 9)
        BDNF signaling pathway
    Wnt Signaling Pathway NetPath
    TNF-alpha/NF-kB Signaling Pathway
    Lissencephaly gene (LIS1) in neuronal migration and development
    Role of Calcineurin-dependent NFAT signaling in lymphocytes

    1 Sino Biological Pathway for CSNK2A1
        Non-Canonical Wnt Pathway

    3 Reactome Pathways for CSNK2A1
        Signal transduction by L1
    WNT mediated activation of DVL
    Condensation of Prometaphase Chromosomes


    Selected Kegg Pathways  (Kegg details for CSNK2A1) (see all 8):
        Ribosome biogenesis in eukaryotes
    NF-kappa B signaling pathway
    Wnt signaling pathway
    Adherens junction
    Tight junction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSNK2A1 (see all 7): 
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CSNK2A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSNK2A1 (P684001, 2, 3 ENSP000002172444) via UniProtKB, MINT, STRING, and/or I2D (see all 470)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224398P678701, 2, 3EBI-347804,EBI-348169 MINT-8206396 MINT-8206373 MINT-8206385 MINT-62785 MINT-62611 MINT-62709 I2D: score=15 
    ENSG00000228875P678701, 2, 3EBI-347804,EBI-348169 MINT-8206396 MINT-8206373 MINT-8206385 MINT-62785 MINT-62611 MINT-62709 I2D: score=15 
    ENSG00000230700P678701, 2, 3EBI-347804,EBI-348169 MINT-8206396 MINT-8206373 MINT-8206385 MINT-62785 MINT-62611 MINT-62709 I2D: score=15 
    ENSG00000224774P678701, 2, 3, ENSP000004156154EBI-347804,EBI-348169 MINT-8206396 MINT-8206373 MINT-8206385 MINT-62785 MINT-62611 MINT-62709 I2D: score=15 STRING: ENSP00000415615
    ENSG00000232960P678701, 2, 3, ENSP000003955464EBI-347804,EBI-348169 MINT-8206396 MINT-8206373 MINT-8206385 MINT-62785 MINT-62611 MINT-62709 I2D: score=15 STRING: ENSP00000395546
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006468protein phosphorylation IDA--
    GO:0007165signal transduction TAS2174700

    Find genes that share ontologies with CSNK2A1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Compounds for CSNK2A1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TMCBDual-kinase inhibitor; inhibits CK2 and ERK8[905105-89-7]
    TBBSelective cell-permeable CK2 inhibitor[17374-26-4]
    TTP 22 High affinity, selective CK2 inhibitor [329907-28-0]
    Ellagic acidSelective inhibitor of CK2. Also inhibits glutathione S-transferase[476-66-4]

    2 HMDB Compounds for CSNK2A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected DrugBank Compounds for CSNK2A1 (see all 24)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzamidine-- 618-39-3target--17139284 17016423 10592235
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423 10592235
    Tetrabromo-2-Benzotriazole-- --target--17139284 17016423 10592235
    Ellagic Acid-- 476-66-4targetinhibitor16610779 19414254
    (5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid-- --target--10592235
    1,2,5,8-tetrahydroxyanthracene-9,10-dione-- --target--10592235
    1,8-Di-Hydroxy-4-Nitro-Anthraquinone-- --target--10592235
    1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One-- --target--10592235
    19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one-- --target--10592235
    2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for CSNK2A1 gene (see all 65)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4,5,6,7-tetrabromobenzotriazole 93.2 11 11988074 (2), 18548199 (1), 16687488 (1), 12869192 (1) (see all 5)
    dmat 83.1 2 20383646 (1), 19424641 (1)
    5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 77.3 10 18556661 (1), 20026644 (1), 11593402 (1), 12748192 (1) (see all 9)
    threonine 76.4 67 12748192 (2), 1590772 (1), 8529132 (1), 8943850 (1) (see all 64)
    serine 75.2 101 10448092 (3), 8384219 (2), 1425701 (2), 15823605 (2) (see all 87)
    apigenin 64.5 5 11673497 (1), 15302569 (1), 16520553 (1), 16442104 (1) (see all 5)
    5,6-dichlorobenzimidazole riboside 63.8 2 8765099 (1), 19043076 (1)
    gtp 55.4 17 8049218 (1), 7735321 (1), 10197447 (1), 10398759 (1) (see all 14)
    phosphocellulose 54.8 6 8696255 (1), 9143340 (1), 2040287 (1), 1835512 (1)
    glycyrrhetinic acid 53.5 2 9654140 (1), 10443459 (1)



    Find genes that share compounds with CSNK2A1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for CSNK2A1 gene (3 alternative transcripts): 
    NM_001895.3  NM_177559.2  NM_177560.2  

    Unigene Cluster for CSNK2A1:

    Casein kinase 2, alpha 1 polypeptide
    Hs.644056  [show with all ESTs]
    Unigene Representative Sequence: NM_177559
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000349736(uc002wdx.1) ENST00000217244(uc002wdw.1) ENST00000400217(uc002wdy.1)
    ENST00000460062 ENST00000609606 ENST00000608066 ENST00000609525 ENST00000608490
    ENST00000400227
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CSNK2A1 (see all 53):
    hsa-miR-330-5p hsa-miR-1224-3p hsa-miR-200a hsa-miR-605 hsa-miR-548l hsa-miR-4275 hsa-miR-3161 hsa-miR-141
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    eBioscience FlowRNA Probe Sets ( VA1-12284) for CSNK2A1 

    Additional mRNA sequence: 

    AB451279.1 AB451411.1 AK302583.1 AK312535.1 AY735339.1 BC002615.2 BC011668.2 BC050036.1 
    BC053532.1 BC071167.1 BT019792.1 DQ354583.1 J02853.1 M55265.1 S53149.1 

    22 DOTS entries:

    DT.99935781  DT.456148  DT.100821389  DT.100821391  DT.101957241  DT.100821379  DT.100821384  DT.97855916 
    DT.100707032  DT.91745722  DT.100821387  DT.95258504  DT.100739418  DT.120821869  DT.120821893  DT.120821992 
    DT.40245765  DT.92445999  DT.100821390  DT.120821972  DT.95258004  DT.99936596 

    Selected AceView cDNA sequences (see all 419):

    BF035072 AA885685 AW014368 AI049677 BQ433960 AU131227 AI205526 CA944553 
    AA954443 AI631874 BC071167 BM785307 BE326800 BE550309 F09562 AU133318 
    BM718229 BM999563 AI286069 AA948280 BM742757 AU120646 BU742389 CA487264 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSNK2A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCATCCAGTG
    CSNK2A1 Expression
    About this image


    CSNK2A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Lens
     
     Placenta (Extraembryonic Tissues)
    CSNK2A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSNK2A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.644056
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSNK2A1 (see all 7): 
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Circadian Rhythms in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSNK2A1 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csnk2a11 , 5 casein kinase 2, alpha 1 polypeptide1, 5 94.54(n)1
    98.72(a)1
      2 (74.83 cM)5
    129951  NM_007788.31  NP_031814.21 
     1522268395 
    chicken
    (Gallus gallus)
    Aves CSNK2A11 casein kinase 2, alpha 1 polypeptide 86.87(n)
    97.95(a)
      432370  NM_001002242.1  NP_001002242.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    95(a)
    1 → many
    GL343346.1(62790-83370)
    African clawed frog
    (Xenopus laevis)
    Amphibia X62375.22   -- 79.97(n)    X62375.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ck2a12 casein kinase 2 alpha 1 80.71(n)   30502  BC044403.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CkIIalpha1 , 3 frizzled receptor signaling pathway
    protein kinase3
    casein kinase IIalpha1
    88(a)3
    73.39(n)1
    88.69(a)1
      80D23
    484481  NM_168986.21  NP_730775.11 
    worm
    (Caenorhabditis elegans)
    Secernentea B0205.73
    kin-31
    casein kinase3
    kin-31
    83(a)3
    69.11(n)1
    78.59(a)1
      I(10742092-10744293)3
    1729781  NM_060410.41  NP_492811.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CKA1(YIL035C)4
    CKA21
    Alpha catalytic subunit of casein kinase 2 (CK2), a more4
    CKA21
    57.41(n)1
    59.88(a)1
      9(288908-287790)4
    8542271  NP_014704.11  8547764 
     NP_012229.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G230701 AT2G23070 69.35(n)
    75.54(a)
      816837  NM_127871.4  NP_179889.1 


    ENSEMBL Gene Tree for CSNK2A1 (if available)
    TreeFam Gene Tree for CSNK2A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSNK2A1 gene
    CSNK2A32  CSNK2A22  
    Selected SIMAP similar genes for CSNK2A1 using alignment to 7 protein entries:     CSK21_HUMAN (see all proteins) (see all similar genes):
    CSNK2A3    CSNK2A2    RPS6KA2    CDK3    CDK2    MAPK3
    CDK1    NUAK1    STK11    CCRK    CDK4    DKFZp686O0215
    CDK5    DKFZp686L20222    MAPK1    MAPK13    CDKL4    MAPK14

    Find genes that share paralogs with CSNK2A1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSNK2A1 (see all 1341)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1896797671,2
    --411253(+) AGAGCC/TGATGG 3 -- ds50010--------
    rs1141478901,2
    F--411328(+) GATTAC/GAGTGG 3 -- ds50011Minor allele frequency- G:0.02WA 118
    rs785365371,2
    F--411344(+) CCACTT/CTACAC 3 -- ds50011Minor allele frequency- C:0.01EA 120
    rs1927057071,2
    --411417(+) ACAAAA/GTGAGT 3 -- ds50010--------
    rs1850076311,2
    --411418(+) CAAAAA/TGAGTT 3 -- ds50010--------
    rs61393141,2
    C,H--411439(+) GGATCC/TTTAAT 3 -- ds50016Minor allele frequency- T:0.00NS EA NA 402
    rs2001732811,2
    --411472(+) GGTGC-/TTTTTT 3 -- ds50010--------
    rs61393151,2
    H--411540(+) GGGGCC/TTTGGG 3 -- ds50014Minor allele frequency- T:0.00NS EA 406
    rs750324381,2
    C,F--411572(+) GCAGGC/ACCCTC 3 -- ds50011Minor allele frequency- A:0.09WA 118
    rs1882340781,2
    --411686(+) ACACTA/GGATCT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CSNK2A1 (459116 - 524482 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CSNK2A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673541CNV Deletion23128226
    esv2674635CNV Deletion23128226
    nsv469833CNV Gain16826518
    dgv4509n71CNV Gain21882294
    nsv833891CNV Gain+Loss17160897

    Locus Specific Mutation Databases (LSDB): CSNK2A1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSNK2A1
    DNA2.0 Custom Variant and Variant Library Synthesis for CSNK2A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 115440    OMIM disorders: --

    1 disease for CSNK2A1:    
    About MalaCards
    globozoospermia


    Find genes that share disorders with CSNK2A1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CSNK2A1 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal neovascularization 29.9 3 15557471 (1), 18612802 (1), 16651637 (1)
    cancer 27.2 25 19387548 (2), 14965269 (2), 9820486 (1), 12149649 (1) (see all 22)
    prostate carcinoma 25.5 2 12738992 (1), 16687488 (1)
    mammary tumor 22.8 1 17575143 (1)
    tumors 17.1 20 8037705 (2), 12479100 (1), 9042966 (1), 10862016 (1) (see all 19)
    prostate cancer 8.98 7 17044081 (2), 12738992 (1), 16489027 (1), 18574673 (1) (see all 6)
    metastasis 2.81 1 18062282 (1)
    carcinoma 2.33 1 10533285 (1)
    t-all 1.49 1 8895560 (1)
    astrocytoma 0 1 16520553 (1)

    Genetic Association Database (GAD): CSNK2A1
    Human Genome Epidemiology (HuGE) Navigator: CSNK2A1 (8 documents)

    Export disorders for CSNK2A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSNK2A1 gene, integrated from 10 sources (see all 849):
    (articles sorted by number of sources associating them with CSNK2A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. (PubMed id 2174700)1, 2, 3 Lozeman F.J....Krebs E.G. (Biochemistry 1990)
    2. Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery. (PubMed id 19387550)1, 2, 9 Miyata Y. (Cell. Mol. Life Sci. 2009)
    3. Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. (PubMed id 1766873)1, 3, 9 Yang-Feng T.L....Canaani D. (Nucleic Acids Res. 1991)
    4. The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. (PubMed id 22406621)1, 2 Rabellino A....Scaglioni P.P. (Cancer Res. 2012)
    5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    6. Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A. (PubMed id 19923321)1, 2 MacPherson M.R.... Cano A. (Mol. Biol. Cell 2010)
    7. Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. (PubMed id 20625391)1, 2 Hung M.S.... You L. (PLoS ONE 2010)
    8. Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility. (PubMed id 20610541)1, 4 Lascorz J....Hemminki K. (Carcinogenesis 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (PubMed id 19839995)1, 4 Mansour H.A....Nimgaonkar V.L. (Bipolar Disord 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1457 HGNC: 2457 AceView: CSNK2A1 Ensembl:ENSG00000101266 euGenes: HUgn1457
    ECgene: CSNK2A1 Kegg: 1457 H-InvDB: CSNK2A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CSNK2A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CSNK2A1 gene:
    Search GeneIP for patents involving CSNK2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Browse ELISAs at Cloud-Clone Corp.
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     Browse ESI BIO Cell Lines and PureStem Progenitors for CSNK2A1
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK2A1
     SwitchGear 3'UTR luciferase reporter plasmids for CSNK2A1
     SwitchGear Promoter luciferase reporter plasmids for CSNK2A1
     ThermoFisher Antibody for CSNK2A1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK2A1
     Browse compounds at ApexBio
     Addgene plasmids for CSNK2A1
      Search eBioscience for proteins for CSNK2A1
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CSNK2A1
     antibodies-online antibodies for CSNK2A1 (109 products)
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     antibodies-online proteins for CSNK2A1 (13 products)
           
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