Aliases for CSNK1G3 Gene
Aliases for CSNK1G3 Gene
External Ids for CSNK1G3 Gene
- HGNC: 2456
- Entrez Gene: 1456
- Ensembl: ENSG00000151292
- OMIM: 604253
- UniProtKB: Q9Y6M4
Previous GeneCards Identifiers for CSNK1G3 Gene
- GC05P122511
- GC05P123217
- GC05P122878
- GC05P122957
- GC05P122909
- GC05P118036
- GC05P122848
Summaries for CSNK1G3 Gene
-
This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for CSNK1G3 Gene
CSNK1G3 (Casein Kinase 1 Gamma 3) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G2.
UniProtKB/Swiss-Prot for CSNK1G3 Gene
-
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
-
Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.
No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1G3 Gene
Genomics for CSNK1G3 Gene
Regulatory Elements for CSNK1G3 Gene
Enhancers for CSNK1G3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G123548 | 1.1 | FANTOM5 ENCODE | 20.3 | +37.5 | 37493 | 3.0 | PKNOX1 BMI1 EBF1 RELA ARID3A SCRT2 ETV6 RELB IKZF2 CREM | CSNK1G3 CEP120 KRT18P16 |
| GH05G123428 | 1.4 | FANTOM5 Ensembl ENCODE | 11.2 | -82.5 | -82457 | 1.9 | TBP PKNOX1 FEZF1 RAD21 YY1 FOS CEBPB ATF4 CEBPA STAT3 | CSNK1G3 CEP120 HMGB3P17 |
| GH05G123510 | 1.1 | ENCODE | 9 | +0.1 | 116 | 2.9 | HDGF PKNOX1 FOXA2 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 | SNX2 ENSG00000260686 CSNK1G3 PRDM6 KRT18P16 |
| GH05G123707 | 1.2 | Ensembl ENCODE dbSUPER | 4.5 | +196.6 | 196594 | 3.3 | PKNOX1 JUN ZNF10 USF2 EP300 RAD21 ZNF843 NR2F2 CBX8 JUND | CSNK1G3 GC05P123744 KRT18P16 |
| GH05G123672 | 0.8 | Ensembl ENCODE | 5.1 | +160.7 | 160684 | 2.0 | ZNF664 SMARCA4 SCRT2 CEBPB | CSNK1G3 CEP120 KRT18P16 GC05P123744 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CSNK1G3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CSNK1G3 Gene
- Chromosome:
- 5
- Start:
- 123,512,099 bp from pter
- End:
- 123,617,045 bp from pter
- Size:
- 104,947 bases
- Orientation:
- Plus strand
Genomic View for CSNK1G3 Gene
Genes around CSNK1G3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q23.2 by Ensembl
- 5q23.2 by Entrez Gene
- 5q23.2 by HGNC
CSNK1G3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CSNK1G3 Gene
Proteins for CSNK1G3 Gene
-
Protein details for CSNK1G3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6M4-KC1G3_HUMAN
- Recommended name:
- Casein kinase I isoform gamma-3
- Protein Accession:
- Q9Y6M4
- A8K040
- B4DSH2
- B7Z9Q4
- E7EVD0
- Q86WZ7
- Q9Y6M3
Protein attributes for CSNK1G3 Gene
- Size:
- 447 amino acids
- Molecular mass:
- 51389 Da
- Quaternary structure:
-
- Monomer.
- Miscellaneous:
-
- Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.
Three dimensional structures from OCA and Proteopedia for CSNK1G3 Gene
Protein Expression for CSNK1G3 Gene
Selected DME Specific Peptides for CSNK1G3 Gene
- Q9Y6M4:
-
- SSGVLMVGPNFRVGKKIGCGNFGEL
- LIYRDVKPENFL
- TYLRYVRRLDFFEKPDY
- KSRAPQLHLEYRFYK
- SNAPITA
- FDYEYDW
- LKTVLMIAIQL
- DRHGGSVQV
- EQSRRDDLE
- LTGTARY
- LPWQGLKA
- LGKNLYTNEYVAIKLEP
- GTARYMSINTH
- QVVSSTNGELN
- TPIEVLC
- CCCFFKR
- LLGPSLEDLF
- STNGELNTDDPTAG
- IIDFGLA
Post-translational modifications for CSNK1G3 Gene
- Autophosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CSNK1G3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001026982.1
- NP_001038188.1
- NP_001257501.1
- NP_001257502.1
- NP_001257503.1
- NP_004375.2
- XP_005271948.1
- XP_005271949.1
- XP_005271951.1
- XP_005271952.1
- XP_005271953.1
- XP_016864546.1
- XP_016864547.1
- XP_016864548.1
- XP_016864549.1
- XP_016864550.1
- XP_016864551.1
- XP_016864552.1
- XP_016864553.1
- XP_016864554.1
- XP_016864555.1
- XP_016864556.1
- XP_016864557.1
- XP_016864558.1
- XP_016864559.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CSNK1G3
- Novus Biologicals Antibodies for CSNK1G3
-
Abcam antibodies for CSNK1G3
- Invitrogen Antibodies for CSNK1G3
- antibodies-online Antibodies for CSNK1G3: See all 58
- Search GeneTex for Antibodies for CSNK1G3
Protein Products
- EMD Millipore Purified and/or Recombinant CSNK1G3 Protein
- Search Origene for MassSpec and Protein Over-expression Lysates for CSNK1G3
- Origene Custom Protein Services for CSNK1G3
- antibodies-online Proteins for CSNK1G3: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CSNK1G3
-
Abcam proteins for CSNK1G3
Assay Products
Domains & Families for CSNK1G3 Gene
Gene Families for CSNK1G3 Gene
- IUPHAR :
Protein Domains for CSNK1G3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CSNK1G3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y6M4UniProtKB/Swiss-Prot:
KC1G3_HUMAN :- Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Function for CSNK1G3 Gene
Molecular function for CSNK1G3 Gene
- GENATLAS Biochemistry:
- casein kinase 1 gamma 3,predominantly expressed in testis,localized close to D5S622
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by triazolodiamine 1, 5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide, (S)-propane-1,2-diol, 2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine and [4-amino-2-(3-chloroanilino)-1,3-thiazol-5-yl](4-fluorophenyl)methanone.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
Enzyme Numbers (IUBMB) for CSNK1G3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | TAS | 9925945 |
| GO:0004674 | protein serine/threonine kinase activity | IDA | 25500533 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for CSNK1G3 Gene
- MGI mutant phenotypes for CSNK1G3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CSNK1G3:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased cell migration
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Decreased substrate adherent cell growth
- Reduced beta-catenin activity and colon cancer cell proliferation
Animal Models for CSNK1G3 Gene
- MGI Knock Outs for CSNK1G3:
-
- Csnk1g3 tm1a(EUCOMM)Wtsi
Animal Model Products
-
Taconic Biosciences Mouse Models for CSNK1G3
- Cyagen custom Knockout/knockin (KOKI) mouse models for CSNK1G3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CSNK1G3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1G3 gene
- Search ViGene Biosciences for CSNK1G3
CRISPR Products
-
OriGene CRISPR knockouts for CSNK1G3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSNK1G3
- GenScript: Design CRISPR guide RNA sequences for CSNK1G3
miRNA for CSNK1G3 Gene
- miRTarBase miRNAs that target CSNK1G3
-
- hsa-mir-33a-5p (MIRT028223)
- hsa-mir-30a-5p (MIRT028663)
- hsa-mir-5047 (MIRT502677)
- hsa-mir-6516-5p (MIRT502678)
- hsa-mir-7156-3p (MIRT502679)
- hsa-mir-1301-3p (MIRT502680)
- hsa-mir-3663-5p (MIRT502681)
- hsa-mir-503-3p (MIRT502682)
- hsa-mir-5003-3p (MIRT502683)
- hsa-mir-545-3p (MIRT502684)
- hsa-mir-107 (MIRT502685)
- hsa-mir-103a-3p (MIRT502686)
- hsa-mir-5010-3p (MIRT558535)
- hsa-mir-744-3p (MIRT558536)
- hsa-mir-192-3p (MIRT558537)
- hsa-mir-4795-3p (MIRT558538)
- hsa-mir-4423-5p (MIRT558539)
- hsa-mir-6501-5p (MIRT558540)
- hsa-mir-20a-3p (MIRT558541)
- hsa-mir-126-5p (MIRT558542)
- hsa-mir-3591-5p (MIRT710283)
- hsa-mir-142-3p (MIRT710284)
- hsa-mir-6845-3p (MIRT710285)
- hsa-mir-4699-3p (MIRT710286)
- hsa-mir-4280 (MIRT710287)
- hsa-mir-6800-3p (MIRT710288)
miRNA Products
- Search ViGene Biosciences for CSNK1G3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CSNK1G3
- Browse OriGene Inhibitory RNA Products For CSNK1G3
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1G3 gene
Clone Products
-
OriGene ORF clones in human for CSNK1G3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CSNK1G3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CSNK1G3
- VectorBuilder custom plasmid, inducible vectors for CSNK1G3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK1G3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CSNK1G3
-
ViGene Biosciences adenoviral particle packaged cDNA for CSNK1G3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CSNK1G3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1G3 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK1G3 Gene
Localization for CSNK1G3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CSNK1G3 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005737 | cytoplasm | IBA,IEA | -- |
Pathways & Interactions for CSNK1G3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Hedgehog Pathway |
.40
|
|
| 2 | Dopamine-DARPP32 Feedback onto cAMP Pathway | ||
| 3 | Nanog in Mammalian ESC Pluripotency |
.61
|
|
| 4 | GPCR Pathway | ||
| 5 | Signaling in Gap Junctions | ||
Pathways by source for CSNK1G3 Gene
3 BioSystems pathways for CSNK1G3 Gene
1 KEGG pathway for CSNK1G3 Gene
1 GeneGo (Thomson Reuters) pathway for CSNK1G3 Gene
1 Tocris pathway for CSNK1G3 Gene
5 Qiagen pathways for CSNK1G3 Gene
Interacting Proteins for CSNK1G3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006464 | cellular protein modification process | TAS | 9925945 |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006897 | endocytosis | IBA | -- |
| GO:0007165 | signal transduction | TAS | 9925945 |
| GO:0008360 | regulation of cell shape | IBA | -- |
No data available for SIGNOR curated interactions for CSNK1G3 Gene
Drugs & Compounds for CSNK1G3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 | |||
| {(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE | Experimental | Pharma | Target | 0 | ||
| {[4-AMINO-2-(3-CHLOROANILINO)-1,3-THIAZOL-5-YL](4-FLUOROPHENYL)METHANONE | Experimental | Pharma | Target | 0 | ||
| 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | Experimental | Pharma | Target | 0 | ||
| Purvalanol A | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(5) Tocris Compounds for CSNK1G3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CKI 7 dihydrochloride | CK1 inhibitor | 1177141-67-1 |
| D 4476 | Selective CK1 inhibitor. Also inhibits TGF-betaRI | 301836-43-1 |
| LH 846 | Selective casein kinase 1delta inhibitor | 639052-78-1 |
| PF 4800567 hydrochloride | Selective casein kinase 1eta inhibitor | 1391052-28-0 |
| PF 670462 | Potent and selective CK1eta and CK1delta inhibitor | 950912-80-8 |
(1) ApexBio Compounds for CSNK1G3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| PF-670462 | CK1 ε/δ inhibitor | 950912-80-8 |
Drug Products
- ApexBio compounds for CSNK1G3
Transcripts for CSNK1G3 Gene
mRNA/cDNA for CSNK1G3 Gene
- (26) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (134) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CSNK1G3 Gene
- Casein kinase 1, gamma 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CSNK1G3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSNK1G3
- GenScript: Design CRISPR guide RNA sequences for CSNK1G3
miRNA Products
- Search ViGene Biosciences for CSNK1G3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CSNK1G3
- Browse OriGene Inhibitory RNA Products For CSNK1G3
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1G3 gene
Clone Products
-
OriGene ORF clones in human for CSNK1G3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CSNK1G3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CSNK1G3
- VectorBuilder custom plasmid, inducible vectors for CSNK1G3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK1G3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | - |
Expression for CSNK1G3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
This gene is overexpressed in Plasma (58.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSNK1G3 Gene
NURSA nuclear receptor signaling pathways regulating expression of CSNK1G3 Gene:
CSNK1G3SOURCE GeneReport for Unigene cluster for CSNK1G3 Gene:
Hs.129206Evidence on tissue expression from TISSUES for CSNK1G3 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for CSNK1G3
-
OriGene qPCR primer pairs for CSNK1G3
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1G3 Gene
Orthologs for CSNK1G3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CSNK1G3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CSNK1G3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CSNK1G3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Csnk1g3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Csnk1g3 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CSNK1G3 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CSNK1G3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | csnk1g3 34 |
|
||
| Str.7252 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.33424 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | csnk1g2b 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003997 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | gish 36 34 35 |
|
||
| CG9962 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | csnk-1 35 |
|
OneToMany | |
| Y106G6E.6 36 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HRR25 35 |
|
OneToMany | |
| YCK3 37 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2609 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3005 34 |
|
- Species where no ortholog for CSNK1G3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CSNK1G3 Gene
Paralogs for CSNK1G3 Gene
(6) SIMAP similar genes for CSNK1G3 Gene using alignment to 2 proteins:
Variants for CSNK1G3 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000012535 | -- | 123,516,351(+) | TGAAC(C/T)GCTCA | intron-variant | |
| rs1000044655 | -- | 123,552,386(+) | TGATC(C/T)ACCTG | intron-variant | |
| rs1000065318 | -- | 123,612,299(+) | ATGGC(A/G)GAAAT | intron-variant | |
| rs1000070508 | -- | 123,545,499(+) | TTTTA(C/T)GAATG | intron-variant, utr-variant-5-prime | |
| rs1000080910 | -- | 123,538,876(+) | ACTAT(G/T)AAGAT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2730717 | CNV | deletion | 23290073 |
| esv3606611 | CNV | loss | 21293372 |
| esv3606612 | CNV | loss | 21293372 |
| nsv507289 | OTHER | sequence alteration | 20534489 |
| nsv527734 | CNV | loss | 19592680 |
| nsv968239 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.34;
7.55% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CSNK1G3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1G3 Gene
Disorders for CSNK1G3 Gene
Relevant External Links for CSNK1G3
No disorders were found for CSNK1G3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK1G3 Gene
Publications for CSNK1G3 Gene
- Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3). (PMID: 9925945) Kusuda J. … Hashimoto K. (Cytogenet. Cell Genet. 1998) 2 3 4 22 64
- Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PMID: 19451621) Landers J.E. … Brown R.H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. (PMID: 26389662) Raman M. … Harper J.W. (Nat. Cell Biol. 2015) 3 64
Products for CSNK1G3 Gene
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- Custom Antibody ServicesOriGene Antibodies for CSNK1G3
- Browse OriGene ELISA Kits
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- Search Origene for MassSpec and Protein Over-expression Lysates for CSNK1G3
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CSNK1G3
- Browse OriGene Inhibitory RNA Products For CSNK1G3
- OriGene qPCR primer pairs and template standards for CSNK1G3
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- OriGene ORF clones in human for CSNK1G3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CSNK1G3
- GenScript: Next-day shipping cDNA ORF clone for CSNK1G3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CSNK1G3
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- GenScript: Design CRISPR guide RNA sequences for CSNK1G3
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- Novus Biologicals Antibodies for CSNK1G3
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- Abcam antibodies for CSNK1G3
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- Search for Assays for CSNK1G3 at Abcam
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- Taconic Biosciences Mouse Models for CSNK1G3
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- Humanized Mice
- Invitrogen Antibodies for CSNK1G3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CSNK1G3
- Addgene plasmids for CSNK1G3
- antibodies-online Antibodies for CSNK1G3: See all 58
- Search antibodies-online for kits
- antibodies-online Proteins for CSNK1G3: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for CSNK1G3
- Search GeneTex for Proteins for CSNK1G3
- ViGene Biosciences adenoviral particle packaged cDNA for CSNK1G3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CSNK1G3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CSNK1G3 gene
- Search ViGene Biosciences for CSNK1G3
- Search Santa Cruz Biotechnology (SCBT) for CSNK1G3 Antibodies
- Search Santa Cruz Biotechnology (SCBT) for CSNK1G3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CSNK1G3
- Horizon Cell Lines for CSNK1G3
- Cyagen custom Knockout/knockin (KOKI) mouse models for CSNK1G3
- VectorBuilder custom plasmid, inducible vectors for CSNK1G3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK1G3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CSNK1G3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
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- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
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- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
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- (53) GenBank
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- (55) HORDE
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- (62) NCBI
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- (68) Abcam
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- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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- (84) DISEASES
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- (100) COMPARTMENTS
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- (155) Gene ORGANizer