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Aliases for CSNK1G3 Gene

Aliases for CSNK1G3 Gene

  • Casein Kinase 1, Gamma 3 2 3
  • CKI-Gamma 3 3 4
  • EC 2.7.11.1 4 64
  • Casein Kinase I Isoform Gamma-3 3
  • EC 2.7.11 64
  • CSNK1G3L 3

External Ids for CSNK1G3 Gene

Summaries for CSNK1G3 Gene

Entrez Gene Summary for CSNK1G3 Gene

  • This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for CSNK1G3 Gene

CSNK1G3 (Casein Kinase 1, Gamma 3) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for CSNK1G3 Gene

  • Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).

Tocris Summary for CSNK1G3 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in a number of cellular processes including DNA repair, cell division, nuclear localization and membrane transport. CK1 isoforms also have key roles in the developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor, CK1alpha is thought to phosphorylate beta-catenin as part of its degradation process. Upon binding of Wnt to its receptor (Frizzled) CK1epsilon phosphorylates the intracellular signaling protein, Dishevelled and CK1gamma directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1alpha plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound state, and then when Hh binds to Patched, CK1alpha phosphorylates the 7-TM co-receptor, Smoothened.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1G3 Gene

Genomics for CSNK1G3 Gene

Genomic Location for CSNK1G3 Gene

Start:
123,512,099 bp from pter
End:
123,617,045 bp from pter
Size:
104,947 bases
Orientation:
Plus strand

Genomic View for CSNK1G3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSNK1G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1G3 Gene

Regulatory Elements for CSNK1G3 Gene

Proteins for CSNK1G3 Gene

  • Protein details for CSNK1G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6M4-KC1G3_HUMAN
    Recommended name:
    Casein kinase I isoform gamma-3
    Protein Accession:
    Q9Y6M4
    Secondary Accessions:
    • A8K040
    • B4DSH2
    • B7Z9Q4
    • E7EVD0
    • Q86WZ7
    • Q9Y6M3

    Protein attributes for CSNK1G3 Gene

    Size:
    447 amino acids
    Molecular mass:
    51389 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide

    Three dimensional structures from OCA and Proteopedia for CSNK1G3 Gene

    Alternative splice isoforms for CSNK1G3 Gene

neXtProt entry for CSNK1G3 Gene

Proteomics data for CSNK1G3 Gene at MOPED

Post-translational modifications for CSNK1G3 Gene

Domains for CSNK1G3 Gene

Gene Families for CSNK1G3 Gene

UniProtKB/Swiss-Prot:

KC1G3_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q9Y6M4
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.:
    • Q9Y6M4
genes like me logo Genes that share domains with CSNK1G3: view

Function for CSNK1G3 Gene

Molecular function for CSNK1G3 Gene

GENATLAS Biochemistry: casein kinase 1 gamma 3,predominantly expressed in testis,localized close to D5S622
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by triazolodiamine 1, 5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide, (S)-propane-1,2-diol, 2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine and [4-amino-2-(3-chloroanilino)-1,3-thiazol-5-yl](4-fluorophenyl)methanone
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).

Enzyme Numbers (IUBMB) for CSNK1G3 Gene

Gene Ontology (GO) - Molecular Function for CSNK1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9925945
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with CSNK1G3: view
genes like me logo Genes that share phenotypes with CSNK1G3: view

miRNA for CSNK1G3 Gene

miRTarBase miRNAs that target CSNK1G3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CSNK1G3 Gene

Localization for CSNK1G3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1G3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK1G3 Gene COMPARTMENTS Subcellular localization image for CSNK1G3 gene
Compartment Confidence
cytosol 3
chloroplast 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CSNK1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CSNK1G3: view

Pathways for CSNK1G3 Gene

genes like me logo Genes that share pathways with CSNK1G3: view

Pathways by source for CSNK1G3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for CSNK1G3 Gene
2 Sino Biological pathways for CSNK1G3 Gene
1 Tocris pathway for CSNK1G3 Gene

Gene Ontology (GO) - Biological Process for CSNK1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 9925945
GO:0006468 protein phosphorylation --
GO:0006897 endocytosis IBA --
GO:0007165 signal transduction TAS 9925945
GO:0008360 regulation of cell shape IBA --
genes like me logo Genes that share ontologies with CSNK1G3: view

Compounds for CSNK1G3 Gene

(5) Tocris Compounds for CSNK1G3 Gene

Compound Action Cas Number
(R)-DRF053 dihydrochloride Dual CK1/cdk inhibitor [1056016-06-8]
D 4476 Selective CK1 inhibitor. Also inhibits TGF-betaRI [301836-43-1]
PF 4800567 hydrochloride Selective casein kinase 1epsilon inhibitor [1188296-52-7]
PF 670462 Potent and selective CK1epsilon and CK1delta inhibitor [950912-80-8]
TAK 715 Potent p38 MAPK inhibitor; anti-inflammatory [303162-79-0]

(2) HMDB Compounds for CSNK1G3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(4) Drugbank Compounds for CSNK1G3 Gene

genes like me logo Genes that share compounds with CSNK1G3: view

Transcripts for CSNK1G3 Gene

Unigene Clusters for CSNK1G3 Gene

Casein kinase 1, gamma 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: -
SP4: -

Relevant External Links for CSNK1G3 Gene

GeneLoc Exon Structure for
CSNK1G3
ECgene alternative splicing isoforms for
CSNK1G3

Expression for CSNK1G3 Gene

mRNA expression in normal human tissues for CSNK1G3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSNK1G3 Gene

SOURCE GeneReport for Unigene cluster for CSNK1G3 Gene Hs.129206

genes like me logo Genes that share expressions with CSNK1G3: view

Orthologs for CSNK1G3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSNK1G3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK1G3 36
  • 99.93 (n)
  • 100 (a)
CSNK1G3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSNK1G3 36
  • 96.29 (n)
  • 99.29 (a)
CSNK1G3 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSNK1G3 36
  • 96.7 (n)
  • 99.56 (a)
CSNK1G3 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csnk1g3 36
  • 92.67 (n)
  • 99.05 (a)
Csnk1g3 16
Csnk1g3 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSNK1G3 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csnk1g3 36
  • 93.44 (n)
  • 98.88 (a)
lizard
(Anolis carolinensis)
Reptilia CSNK1G3 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33424 36
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk1g3 36
  • 85.99 (n)
  • 96.77 (a)
Str.7252 36
zebrafish
(Danio rerio)
Actinopterygii csnk1g2b 36
  • 70.83 (n)
  • 81.84 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003997 36
  • 64.12 (n)
  • 74.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta gish 36
  • 62.68 (n)
  • 71.03 (a)
gish 37
  • 60 (a)
OneToMany
gish 38
  • 72 (a)
CG9962 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea csnk-1 37
  • 66 (a)
OneToMany
Y106G6E.6 38
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRR25 37
  • 34 (a)
OneToMany
YCK3 39
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3005 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2609 37
  • 72 (a)
OneToMany
Species with no ortholog for CSNK1G3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK1G3 Gene

ENSEMBL:
Gene Tree for CSNK1G3 (if available)
TreeFam:
Gene Tree for CSNK1G3 (if available)

Paralogs for CSNK1G3 Gene

Selected SIMAP similar genes for CSNK1G3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CSNK1G3: view

Variants for CSNK1G3 Gene

Sequence variations from dbSNP and Humsavar for CSNK1G3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs922433 -- 123,602,107(-) CACTT(C/G)CTTCC intron-variant
rs931060 -- 123,599,086(-) TAAAA(C/T)GGAAT intron-variant
rs964284 -- 123,592,490(-) TCTTC(A/G)ATAAA intron-variant
rs982529 -- 123,595,365(+) TATGC(A/T)ACAAT intron-variant
rs1002112 -- 123,536,948(-) atcct(C/T)gccaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK1G3 Gene

Variant ID Type Subtype PubMed ID
nsv527734 CNV Loss 19592680
esv2730717 CNV Deletion 23290073
nsv882816 CNV Gain 21882294
nsv882817 CNV Gain 21882294
nsv507289 CNV Insertion 20534489

Relevant External Links for CSNK1G3 Gene

HapMap Linkage Disequilibrium report
CSNK1G3

Disorders for CSNK1G3 Gene

(1) University of Copenhagen DISEASES for CSNK1G3 Gene

Relevant External Links for CSNK1G3

Genetic Association Database (GAD)
CSNK1G3
genes like me logo Genes that share disorders with CSNK1G3: view

No data available for UniProtKB/Swiss-Prot for CSNK1G3 Gene

Publications for CSNK1G3 Gene

  1. Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3). (PMID: 9925945) Kusuda J. … Hashimoto K. (Cytogenet. Cell Genet. 1998) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PMID: 19451621) Landers J.E. … Brown R.H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 49
  4. Network organization of the human autophagy system. (PMID: 20562859) Behrends C. … Harper J.W. (Nature 2010) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for CSNK1G3 Gene

Sources for CSNK1G3 Gene

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