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CSNK1G3 Gene

protein-coding   GIFtS: 67
GCID: GC05P122848

Casein Kinase 1, Gamma 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Casein Kinase 1, Gamma 31 2
CKI-Gamma 32 3
EC 2.7.11.13 8
CSNK1G3L2
Casein Kinase I Isoform Gamma-32
EC 2.7.118

External Ids:    HGNC: 24561   Entrez Gene: 14562   Ensembl: ENSG000001512927   OMIM: 6042535   UniProtKB: Q9Y6M43   

Export aliases for CSNK1G3 gene to outside databases

Previous GC identifers: GC05P122511 GC05P123217 GC05P122878 GC05P122957 GC05P122909 GC05P118036


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSNK1G3 Gene:
This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other
acidic proteins. A related protein in the African clawed frog participates in the transmission of
Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been
observed for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for CSNK1G3 Gene:
CSNK1G3 (casein kinase 1, gamma 3) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is VRK3.

UniProtKB/Swiss-Prot: KC1G3_HUMAN, Q9Y6M4
Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential
utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins.
Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity)

summary for CSNK1G3 Gene:
Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1,
gamma2, gamma3, delta and epsilon. CK1 is involved in a number of cellular processes including DNA repair,
cell division, nuclear localization and membrane transport. CK1 isoforms also have key roles in the
developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor,
CK1alpha is thought to phosphorylate beta-catenin as part of its degradation process. Upon binding of Wnt to
its receptor (Frizzled) CK1epsilon phosphorylates the intracellular signaling protein, Dishevelled and
CK1gamma directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction
to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1alpha
plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound
state, and then when Hh binds to Patched, CK1alpha phosphorylates the 7-TM co-receptor, Smoothened.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSNK1G3 gene promoter:
         GATA-3   p300   FOXD3   FOXL1   E47   POU2F1   POU2F1a   Hand1   c-Myb   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CSNK1G3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSNK1G3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23   Ensembl cytogenetic band:  5q23.2   HGNC cytogenetic band: 5q23

CSNK1G3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK1G3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P122848:  view genomic region     (about GC identifiers)

Start:
122,847,793 bp from pter      End:
122,952,739 bp from pter
Size:
104,947 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KC1G3_HUMAN, Q9Y6M4 (See protein sequence)
Recommended Name: Casein kinase I isoform gamma-3  
Size: 447 amino acids; 51389 Da
Subunit: Monomer (By similarity)
Miscellaneous: Triazolodiamine 1 is a commercial name for
5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
Selected PDB 3D structures from and Proteopedia for CSNK1G3 (see all 9):
2CHL (3D)        2IZR (3D)        2IZS (3D)        2IZT (3D)        2IZU (3D)        4G16 (3D)    
Secondary accessions: A8K040 B4DSH2 B7Z9Q4 E7EVD0 Q86WZ7 Q9Y6M3
Alternative splicing: 6 isoforms:  Q9Y6M4-1   Q9Y6M4-2   Q9Y6M4-3   Q9Y6M4-4   Q9Y6M4-5   Q9Y6M4-6   (Contains a phosphoserine at position 254)

Explore the universe of human proteins at neXtProt for CSNK1G3: NX_Q9Y6M4

Explore proteomics data for CSNK1G3 at MOPED

Post-translational modifications: 

  • Autophosphorylated (By similarity)1
  • Ubiquitination2 at Lys253
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CSNK1G3 (Q9Y6M4) (see all 19)
     CCCFFKR  IIDFGLA  SNAPITA  FDYEYDW 


    See CSNK1G3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001026982.1  NP_001038188.1  NP_001257501.1  NP_001257502.1  NP_001257503.1  NP_004375.2  

    ENSEMBL proteins: 
     ENSP00000421385   ENSP00000421998   ENSP00000429412   ENSP00000423838   ENSP00000354942  
     ENSP00000353904   ENSP00000429914   ENSP00000378807   ENSP00000378806   ENSP00000334735  

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    antibodies-online proteins for CSNK1G3 (5 products) 

     
    antibodies-online peptides for CSNK1G3

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    antibodies-online antibodies for CSNK1G3 (35 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: casein kinase 1, gamma 3
    Casein kinase 1 (CK1) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR022247 Casein_kinase-1_gamma_C

    Graphical View of Domain Structure for InterPro Entry Q9Y6M4

    ProtoNet protein and cluster: Q9Y6M4

    UniProtKB/Swiss-Prot: KC1G3_HUMAN, Q9Y6M4
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I
    subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CSNK1G3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KC1G3_HUMAN, Q9Y6M4
    Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential
    utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins.
    Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by triazolodiamine 1,
    5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide,
    (S)-propane-1,2-diol, 2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol,
    N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine and
    [4-amino-2-(3-chloroanilino)-1,3-thiazol-5-yl](4-fluorophenyl)methanone

         Genatlas biochemistry entry for CSNK1G3:
    casein kinase 1 gamma 3,predominantly expressed in testis,localized close to D5S622

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9925945
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with CSNK1G3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CSNK1G3:
     Decreased substrate adherent c  Increased cell death HMECs cel  Reduced beta-catenin activity  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CSNK1G3

    miRNA
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    miRTarBase miRNAs that target CSNK1G3:
    hsa-mir-33a-5p (MIRT028223), hsa-mir-30a-5p (MIRT028663)

    Block miRNA regulation of human, mouse, rat CSNK1G3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSNK1G3 (see all 46):
    hsa-miR-429 hsa-miR-200a hsa-miR-624* hsa-miR-650 hsa-miR-141 hsa-miR-649 hsa-miR-133a hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidCSNK1G3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1G3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KC1G3_HUMAN, Q9Y6M4: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    chloroplast2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CSNK1G3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSNK1G3 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    2Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    3GPCR Pathway
    NFAT in Immune Response0.58
    4Translation Insulin regulation of translation
    Translation Regulation activity of EIF20.47
    5Basal cell carcinoma
    Hedgehog signaling pathway0.43


    Find genes that share SuperPaths with CSNK1G3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CSNK1G3
        GSK3 Signaling
    Signaling in Gap Junctions
    WNT Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway
    NFAT in Immune Response

    1 Tocris Bioscience Pathway for CSNK1G3
        Hedgehog Pathway

    1 GeneGo (Thomson Reuters) Pathway for CSNK1G3
        Translation Regulation of EIF2 activity

    3 BioSystems Pathways for CSNK1G3
        FoxO family signaling
    p53 pathway
    Hedgehog signaling events mediated by Gli proteins

    2 Sino Biological Pathways for CSNK1G3
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway


    1 Kegg Pathway  (Kegg details for CSNK1G3):
        Hedgehog signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSNK1G3
    Interactions:

        Search GeneGlobe Interaction Network for CSNK1G3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSNK1G3 (Q9Y6M43 ENSP000003539044) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NSFP464593, ENSP000003812934I2D: score=2 STRING: ENSP00000381293
    PPP1R14AQ96A003, ENSP000003012424I2D: score=1 STRING: ENSP00000301242
    YWHABENSP000003001614STRING: ENSP00000300161
    YWHAEENSP000002643354STRING: ENSP00000264335
    YWHAQENSP000002380814STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS9925945
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction TAS9925945
    GO:0016055Wnt signaling pathway IEA--

    Find genes that share ontologies with CSNK1G3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CSNK1G3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PF 4800567 hydrochlorideSelective casein kinase 1epsilon inhibitor[1188296-52-7]
    D 4476Selective CK1 inhibitor. Also inhibits TGF-betaRI[301836-43-1]
    (R)-DRF053 dihydrochlorideDual CK1/cdk inhibitor[1056016-06-8]
    TAK 715Potent p38 MAPK inhibitor; anti-inflammatory[303162-79-0]
    PF 670462Potent and selective CK1epsilon and CK1delta inhibitor[950912-80-8]

    2 HMDB Compounds for CSNK1G3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    4 DrugBank Compounds for CSNK1G3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE-- --target--10592235
    Purvalanol A6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine (see all 2)212844-53-6target--10592235
    {(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE-- --target--10592235
    {[4-AMINO-2-(3-CHLOROANILINO)-1,3-THIAZOL-5-YL](4-FLUOROPHENYL)METHANONE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CSNK1G3 gene (7 alternative transcripts): 
    NM_001031812.3  NM_001044723.2  NM_001270572.1  NM_001270573.1  NM_001270574.1  NM_004384.4  NM_001044722.1  

    Unigene Cluster for CSNK1G3:

    Casein kinase 1, gamma 3
    Hs.129206  [show with all ESTs]
    Unigene Representative Sequence: NM_001031812
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508708 ENST00000511130 ENST00000512718 ENST00000521364 ENST00000510842
    ENST00000361991 ENST00000360683 ENST00000514131 ENST00000515322 ENST00000395412(uc003ktl.3)
    ENST00000395411(uc003ktm.3) ENST00000345990(uc003ktn.3 uc003kto.3 uc011cwr.2 uc011cws.2 uc010jda.3)

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    Additional mRNA sequence: 

    AF049089.1 AF049090.1 AK289405.1 AK299739.1 AK316019.1 BC047567.1 

    9 DOTS entries:

    DT.312581  DT.100783330  DT.100783329  DT.120885033  DT.100783331  DT.91758761  DT.97842593  DT.120885039 
    DT.40131715 

    Selected AceView cDNA sequences (see all 134):

    AW296409 AI073822 BQ024485 AI492168 AI143312 AV714207 AW976084 BF197397 
    AW768534 BM453983 BX498215 BM829573 AI039515 CA440488 AA417569 BM973922 
    AI394343 AA894367 BM716566 AI831223 AA805363 BF834815 CB250578 AA394099 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                        -                                       
    SP2:                                                        -                       -               
    SP3:                                                        -                                       
    SP4:                                                                                -               


    ECgene alternative splicing isoforms for CSNK1G3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSNK1G3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATGGTGTC
    CSNK1G3 Expression
    About this image


    CSNK1G3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Cerebral Cortex
             Substantia Nigra   
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    CSNK1G3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSNK1G3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129206
        Custom PCR Arrays for CSNK1G3
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CSNK1G3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csnk1g31 , 5 casein kinase 1, gamma 31, 5 92.67(n)1
    99.05(a)1
      18 (29.10 cM)5
    704251  NM_152809.21  NP_690022.21 
     538621135 
    lizard
    (Anolis carolinensis)
    Reptilia CSNK1G36
    casein kinase 1, gamma 3
    96(a)
    1 ↔ 1
    GL343193.1(12660019-12715928)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.334242 Xenopus laevis transcribed sequence with moderate similarity more 84.4(n)    BU914374.1 
    zebrafish
    (Danio rerio)
    Actinopterygii csnk1g2b1 casein kinase 1, gamma 2b 70.83(n)
    81.84(a)
      561724  NM_001045850.1  NP_001039315.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gish1 , 3 glia cell migration casein kinase I3
    gilgamesh1
    72(a)
    (best of 2)3
    62.68(n)1
    71.03(a)1
      89B173
    497011  NM_001260208.21  NP_001247137.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y106G6E.63 casein kinase like 65(a)   I(10236146-10237779)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YCK3(YER123W)4 Palmitoylated, vacuolar membrane-localized casein kinase more   --   5(404813-406387) 856860  NP_011049.2 


    ENSEMBL Gene Tree for CSNK1G3 (if available)
    TreeFam Gene Tree for CSNK1G3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSNK1G3 gene
    VRK32  VRK12  VRK22  CSNK1D2  ENSG000002593162  CSNK1A12  CSNK1G22  CSNK1A1L2  
    TTBK12  CSNK1E2  CSNK1G12  TTBK22  
    6 SIMAP similar genes for CSNK1G3 using alignment to 2 protein entries:     KC1G3_HUMAN (see all proteins):
    CSNK1G2    CSNK1G1    CSNK1E    CSNK1D    CSNK1A1L    CSNK1A1

    Find genes that share paralogs with CSNK1G3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSNK1G3 (see all 1885)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502697471,2
    C--122845806(+) CCTGCC/TTCGGC 3 -- us2k10--------
    rs2007611341,2
    --122845881(+) GGTTA-/CTTG  
            
    CTTTT
    3 -- us2k10--------
    rs746782011,2
    C--122845905(+) TTTTTG/TTTTTG 3 -- us2k10--------
    rs1885963891,2
    --122845941(+) GGCTAA/GCCTTA 3 -- us2k10--------
    rs1929973081,2
    --122845953(+) ACTACA/TGGGAG 3 -- us2k10--------
    rs105933581,2
    C--122845972(+) GCCTC-/AAGCC 
            
    TCCCA
    3 -- us2k10--------
    rs1856492461,2
    --122846069(+) CAAAAA/GTCTTC 3 -- us2k10--------
    rs1902298911,2
    --122846099(+) AAACAA/TTTATT 3 -- us2k10--------
    rs1125879491,2
    F--122846205(+) TCGTTG/TTAAGT 3 -- us2k12Minor allele frequency- T:0.05CSA WA 120
    rs1389720451,2
    --122846231(+) CCAGCC/GCATTT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CSNK1G3 (122847793 - 122952739 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CSNK1G3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730717CNV Deletion23290073
    nsv507289CNV Insertion20534489
    nsv527734CNV Loss19592680
    nsv882817CNV Gain21882294
    nsv882816CNV Gain21882294

    Human Gene Mutation Database (HGMD): CSNK1G3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSNK1G3
    DNA2.0 Custom Variant and Variant Library Synthesis for CSNK1G3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604253    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CSNK1G3:
    Hodgkin's lymphoma

    Find genes that share disorders with CSNK1G3           About GenesLikeMe

    Genetic Association Database (GAD): CSNK1G3

    Export disorders for CSNK1G3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSNK1G3 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with CSNK1G3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3). (PubMed id 9925945)1, 2, 3, 9 Kusuda J.... Hashimoto K. (Cytogenet. Cell Genet. 1998)
    2. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PubMed id 19451621)1, 4 Landers J.E....Brown R.H. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1456 HGNC: 2456 AceView: CSNK1G3 Ensembl:ENSG00000151292 euGenes: HUgn1456
    ECgene: CSNK1G3 Kegg: 1456 H-InvDB: CSNK1G3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CSNK1G3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSNK1G3 gene:
    Search GeneIP for patents involving CSNK1G3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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