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Aliases for CSNK1G3 Gene

Aliases for CSNK1G3 Gene

  • Casein Kinase 1 Gamma 3 2 3
  • Casein Kinase 1, Gamma 3 2 3 5
  • CKI-Gamma 3 3 4
  • EC 2.7.11.1 4 63
  • EC 2.7.11 63
  • CSNK1G3L 3

External Ids for CSNK1G3 Gene

Previous GeneCards Identifiers for CSNK1G3 Gene

  • GC05P122511
  • GC05P123217
  • GC05P122878
  • GC05P122957
  • GC05P122909
  • GC05P118036
  • GC05P122848

Summaries for CSNK1G3 Gene

Entrez Gene Summary for CSNK1G3 Gene

  • This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for CSNK1G3 Gene

CSNK1G3 (Casein Kinase 1 Gamma 3) is a Protein Coding gene. Among its related pathways are p53 pathway (Pathway Interaction Database) and Signaling in Gap Junctions. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for CSNK1G3 Gene

  • Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).

Tocris Summary for CSNK1G3 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1G3 Gene

Genomics for CSNK1G3 Gene

Regulatory Elements for CSNK1G3 Gene

Promoters for CSNK1G3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CSNK1G3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CSNK1G3 Gene

Chromosome:
5
Start:
123,512,099 bp from pter
End:
123,617,045 bp from pter
Size:
104,947 bases
Orientation:
Plus strand

Genomic View for CSNK1G3 Gene

Genes around CSNK1G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1G3 Gene

Proteins for CSNK1G3 Gene

  • Protein details for CSNK1G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6M4-KC1G3_HUMAN
    Recommended name:
    Casein kinase I isoform gamma-3
    Protein Accession:
    Q9Y6M4
    Secondary Accessions:
    • A8K040
    • B4DSH2
    • B7Z9Q4
    • E7EVD0
    • Q86WZ7
    • Q9Y6M3

    Protein attributes for CSNK1G3 Gene

    Size:
    447 amino acids
    Molecular mass:
    51389 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

    Three dimensional structures from OCA and Proteopedia for CSNK1G3 Gene

    Alternative splice isoforms for CSNK1G3 Gene

neXtProt entry for CSNK1G3 Gene

Proteomics data for CSNK1G3 Gene at MOPED

Post-translational modifications for CSNK1G3 Gene

Antibody Products

Domains & Families for CSNK1G3 Gene

Gene Families for CSNK1G3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6M4

UniProtKB/Swiss-Prot:

KC1G3_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1G3: view

Function for CSNK1G3 Gene

Molecular function for CSNK1G3 Gene

GENATLAS Biochemistry:
casein kinase 1 gamma 3,predominantly expressed in testis,localized close to D5S622
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by triazolodiamine 1, 5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide, (S)-propane-1,2-diol, 2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine and [4-amino-2-(3-chloroanilino)-1,3-thiazol-5-yl](4-fluorophenyl)methanone.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).

Enzyme Numbers (IUBMB) for CSNK1G3 Gene

genes like me logo Genes that share phenotypes with CSNK1G3: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSNK1G3 Gene

Localization for CSNK1G3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1G3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK1G3 Gene COMPARTMENTS Subcellular localization image for CSNK1G3 gene
Compartment Confidence
cytosol 3
chloroplast 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for CSNK1G3 Gene

Pathways & Interactions for CSNK1G3 Gene

genes like me logo Genes that share pathways with CSNK1G3: view

Pathways by source for CSNK1G3 Gene

2 Sino Biological pathways for CSNK1G3 Gene
1 KEGG pathway for CSNK1G3 Gene
1 GeneGo (Thomson Reuters) pathway for CSNK1G3 Gene
1 Tocris pathway for CSNK1G3 Gene

Gene Ontology (GO) - Biological Process for CSNK1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 9925945
GO:0008360 regulation of cell shape IBA --
GO:0018105 peptidyl-serine phosphorylation IDA 25500533
genes like me logo Genes that share ontologies with CSNK1G3: view

No data available for SIGNOR curated interactions for CSNK1G3 Gene

Drugs & Compounds for CSNK1G3 Gene

(6) Drugs for CSNK1G3 Gene - From: HMDB, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
{(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE Experimental Pharma Target 0
{[4-AMINO-2-(3-CHLOROANILINO)-1,3-THIAZOL-5-YL](4-FLUOROPHENYL)METHANONE Experimental Pharma Target 0
5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE Experimental Pharma Target 0
Purvalanol A Experimental Pharma Target Cyclin-dependent kinase inhibitor 0

(5) Additional Compounds for CSNK1G3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
(R)-CR8
294646-77-8
(R)-DRF053 dihydrochloride
1241675-76-2
D 4476
301836-43-1
PF 670462
950912-80-8
genes like me logo Genes that share compounds with CSNK1G3: view

Transcripts for CSNK1G3 Gene

Unigene Clusters for CSNK1G3 Gene

Casein kinase 1, gamma 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: -
SP4: -

Relevant External Links for CSNK1G3 Gene

GeneLoc Exon Structure for
CSNK1G3
ECgene alternative splicing isoforms for
CSNK1G3

Expression for CSNK1G3 Gene

mRNA expression in normal human tissues for CSNK1G3 Gene

Protein differential expression in normal tissues from HIPED for CSNK1G3 Gene

This gene is overexpressed in Plasma (58.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSNK1G3 Gene



SOURCE GeneReport for Unigene cluster for CSNK1G3 Gene Hs.129206

genes like me logo Genes that share expression patterns with CSNK1G3: view

Protein tissue co-expression partners for CSNK1G3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSNK1G3 Gene

Orthologs for CSNK1G3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSNK1G3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK1G3 36
  • 100 (a)
OneToOne
CSNK1G3 35
  • 99.93 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CSNK1G3 35
  • 96.29 (n)
  • 99.29 (a)
CSNK1G3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSNK1G3 36
  • 94 (a)
OneToOne
CSNK1G3 35
  • 96.7 (n)
  • 99.56 (a)
mouse
(Mus musculus)
Mammalia Csnk1g3 16
Csnk1g3 36
  • 99 (a)
OneToOne
Csnk1g3 35
  • 92.67 (n)
  • 99.05 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CSNK1G3 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csnk1g3 35
  • 93.44 (n)
  • 98.88 (a)
lizard
(Anolis carolinensis)
Reptilia CSNK1G3 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33424 35
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk1g3 35
  • 85.99 (n)
  • 96.77 (a)
Str.7252 35
zebrafish
(Danio rerio)
Actinopterygii csnk1g2b 35
  • 70.83 (n)
  • 81.84 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003997 35
  • 64.12 (n)
  • 74.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta gish 35
  • 62.68 (n)
  • 71.03 (a)
gish 36
  • 60 (a)
OneToMany
CG9962 37
  • 42 (a)
gish 37
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea Y106G6E.6 37
  • 65 (a)
csnk-1 36
  • 66 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRR25 36
  • 34 (a)
OneToMany
YCK3 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3005 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2609 36
  • 72 (a)
OneToMany
Species with no ortholog for CSNK1G3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK1G3 Gene

ENSEMBL:
Gene Tree for CSNK1G3 (if available)
TreeFam:
Gene Tree for CSNK1G3 (if available)

Paralogs for CSNK1G3 Gene

(6) SIMAP similar genes for CSNK1G3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CSNK1G3: view

Variants for CSNK1G3 Gene

Sequence variations from dbSNP and Humsavar for CSNK1G3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1059259 -- 123,615,217(+) GTGAT(A/G)TATGT utr-variant-3-prime
rs1060557 -- 123,511,295(-) CAAGT(C/T)CTTTC upstream-variant-2KB
rs1004434 -- 123,535,792(-) TGATA(A/T)CTGAA intron-variant
rs1478419 -- 123,610,576(-) GGCTT(G/T)TGCTA intron-variant
rs1422260 -- 123,534,927(+) gtgcc(A/G)ttgta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK1G3 Gene

Variant ID Type Subtype PubMed ID
nsv527734 CNV Loss 19592680
esv2730717 CNV Deletion 23290073
nsv882816 CNV Gain 21882294
nsv882817 CNV Gain 21882294
nsv507289 CNV Insertion 20534489

Variation tolerance for CSNK1G3 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK1G3 Gene

HapMap Linkage Disequilibrium report
CSNK1G3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1G3 Gene

Disorders for CSNK1G3 Gene

Relevant External Links for CSNK1G3

Genetic Association Database (GAD)
CSNK1G3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK1G3

No disorders were found for CSNK1G3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK1G3 Gene

Publications for CSNK1G3 Gene

  1. Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3). (PMID: 9925945) Kusuda J. … Hashimoto K. (Cytogenet. Cell Genet. 1998) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Phosphorylation of LRRK2 by casein kinase 1I+ regulates trans-Golgi clustering via differential interaction with ARHGEF7. (PMID: 25500533) Chia R. … Cookson M.R. (Nat Commun 2014) 3
  4. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3
  5. Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu. (PMID: 23047923) Miyakawa K. … Ryo A. (Sci Signal 2012) 3

Products for CSNK1G3 Gene

Sources for CSNK1G3 Gene

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