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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSNK1G2 Gene

protein-coding   GIFtS: 68
GCID: GC19P001941

Casein Kinase 1, Gamma 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Casein Kinase 1, Gamma 21 2     Casein Kinase 1 Isoform Gamma-22
CKI-Gamma 22 3     Casein Kinase I Isoform Gamma-22
EC 2.7.11.13 8     CK1G23
CK1g22     EC 2.7.118

External Ids:    HGNC: 24551   Entrez Gene: 14552   Ensembl: ENSG000001332757   OMIM: 6022145   UniProtKB: P783683   

Export aliases for CSNK1G2 gene to outside databases

Previous GC identifers: GC19P002032 GC19P001881 GC19P001892 GC19P001920 GC19P001713


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CSNK1G2 Gene: 
CSNK1G2 (casein kinase 1, gamma 2) is a protein-coding gene. Diseases associated with CSNK1G2 include follicular adenoma, and febrile seizures, and among its related super-pathways are Sphingolipid metabolism and Non-Canonical Wnt Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and glycoprotein binding. An important paralog of this gene is VRK3.

UniProtKB/Swiss-Prot: KC1G2_HUMAN, P78368
Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential
utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins.
Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain
development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast
synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination
and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of
the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus
down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis

summary for CSNK1G2 Gene:
Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1,
gamma2, gamma3, delta and epsilon. CK1 is involved in a number of cellular processes including DNA repair,
cell division, nuclear localization and membrane transport. CK1 isoforms also have key roles in the
developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor,
CK1alpha is thought to phosphorylate beta-catenin as part of its degradation process. Upon binding of Wnt to
its receptor (Frizzled) CK1epsilon phosphorylates the intracellular signaling protein, Dishevelled and
CK1gamma directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction
to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1alpha
plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound
state, and then when Hh binds to Patched, CK1alpha phosphorylates the 7-TM co-receptor, Smoothened.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSNK1G2 gene promoter:
         USF1   SREBP-1c   USF2   USF-1:USF-2   GATA-1   SREBP-1b   SREBP-1a   USF-1   c-Myb   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK1G2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

CSNK1G2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK1G2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001941:  view genomic region     (about GC identifiers)

Start:
1,941,161 bp from pter      End:
1,981,337 bp from pter
Size:
40,177 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KC1G2_HUMAN, P78368 (See protein sequence)
Recommended Name: Casein kinase I isoform gamma-2  
Size: 415 amino acids; 47457 Da
Subunit: Monomer (By similarity). Interacts with MTA1 (short isoform) in the cytoplasm. Binds to PER1 and triggers
its proteasomal degradation. Interacts with SMAD3
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for CSNK1G2:
2C47 (3D)    
Secondary accessions: B5BU42 O00704 Q8WUB1

Explore the universe of human proteins at neXtProt for CSNK1G2: NX_P78368

Explore proteomics data for CSNK1G2 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78368

  • 4/17 DME Specific Peptides for CSNK1G2 (P78368) (see all 17)
     CCCFFKR  IIDFGLA  SNAPITA  FDYEYDW 

    CSNK1G2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CSNK1G2 Protein Expression
    REFSEQ proteins: NP_001310.3  
    ENSEMBL proteins: 
     ENSP00000255641   ENSP00000467214   ENSP00000465106   ENSP00000468637  
    Reactome Protein details: P78368
    Human Recombinant Protein Products for CSNK1G2: 
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    Sino Biological Recombinant Protein for CSNK1G2
    Sino Biological Cell Lysate for CSNK1G2 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    CSNK1G2 for ontologies           About GeneDecksing



    CSNK1G2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: casein kinase 1, gamma 2 
    Casein kinase 1 (CK1) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom
     IPR022247 Casein_kinase-1_gamma_C

    Graphical View of Domain Structure for InterPro Entry P78368

    ProtoNet protein and cluster: P78368

    UniProtKB/Swiss-Prot: KC1G2_HUMAN, P78368
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I
    subfamily
    Similarity: Contains 1 protein kinase domain


    CSNK1G2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KC1G2_HUMAN, P78368
    Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential
    utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins.
    Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain
    development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast
    synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination
    and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of
    the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus
    down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Stimulated by estrogen. Repressed by 5-iodotubercidin (DB04604)

         Genatlas biochemistry entry for CSNK1G2:
    casein kinase 1 gamma 2,predominantly expressed in testis,may be involved in signaling pathways downstream of RTKS

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0001948glycoprotein binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS9403068
    GO:0004713protein tyrosine kinase activity ----
         
    CSNK1G2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CSNK1G2:
     Decreased substrate adherent c  Increased cell death HMECs cel  Stronger migration 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidCSNK1G2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CSNK1G2 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.63
    Sphingolipid de novo biosynthesis0.47
    2Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    4Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    5GPCR Pathway
    NFAT in Immune Response0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CSNK1G2
        Translation Regulation activity of EIF2

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSNK1G2
        GSK3 Signaling
    Signaling in Gap Junctions
    WNT Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway
    NFAT in Immune Response

    1 Tocris Bioscience Pathway for CSNK1G2
        Hedgehog Pathway

    1 GeneGo (Thomson Reuters) Pathway for CSNK1G2
        Translation Regulation of EIF2 activity

    3 BioSystems Pathways for CSNK1G2
        FoxO family signaling
    p53 pathway
    Hedgehog signaling events mediated by Gli proteins

    2 Sino Biological Pathways for CSNK1G2 
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    4        Reactome Pathways for CSNK1G2
        Sphingolipid metabolism
    Metabolism
    Metabolism of lipids and lipoproteins
    Sphingolipid de novo biosynthesis


    1         Kegg Pathway  (Kegg details for CSNK1G2):
        Hedgehog signaling pathway


    CSNK1G2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CSNK1G2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/108 Interacting proteins for CSNK1G2 (P783682, 3 ENSP000002556414) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COL4A3BPQ9Y5P42, 3, ENSP000003698624MINT-67288 I2D: score=5 STRING: ENSP00000369862
    RUNDC3BQ96NL02, 3, ENSP000003377324MINT-8252934 I2D: score=2 STRING: ENSP00000337732
    C2orf44Q9H6R72, 3MINT-8252912 I2D: score=2 
    ENSG00000096150P622693I2D: score=2 
    ENSG00000204221O152133I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS9403068
    GO:0006665sphingolipid metabolic process TAS--
    GO:0007165signal transduction TAS9403068
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030148sphingolipid biosynthetic process TAS--

    CSNK1G2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CSNK1G2 for compounds           About GeneDecksing

    EMD Millipore small molecules for CSNK1G2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CSNK1G2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PF 4800567 hydrochlorideSelective casein kinase 1epsilon inhibitor[1188296-52-7]
    D 4476Selective CK1 inhibitor. Also inhibits TGF-betaRI[301836-43-1]
    (R)-DRF053 dihydrochlorideDual CK1/cdk inhibitor[1056016-06-8]
    TAK 715Potent p38 MAPK inhibitor; anti-inflammatory[303162-79-0]
    PF 670462Potent and selective CK1epsilon and CK1delta inhibitor[950912-80-8]

    2 HMDB Compounds for CSNK1G2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 DrugBank Compounds for CSNK1G2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-iodotubercidin-- 24386-93-4target--10592235
    IC261-- --target--10592235
    N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide-- --target--10592235

    1 Novoseek inferred chemical compound relationship for CSNK1G2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 28.2 1 10409710 (1)

    Search CenterWatch for drugs/clinical trials and news about CSNK1G2 / KC1G2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for CSNK1G2 gene: 
    NM_001319.6  

    Unigene Cluster for CSNK1G2:

    Casein kinase 1, gamma 2
    Hs.651905  [show with all ESTs]
    Unigene Representative Sequence: NM_001319
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255641(uc002lul.4 uc010dsu.3) ENST00000587123 ENST00000591752
    ENST00000589350 ENST00000589385 ENST00000591002 ENST00000585959 ENST00000590106
    ENST00000585957 ENST00000589861
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    Additional mRNA sequence: 

    AB451278.1 AB451410.1 AF001177.1 AY007134.1 BC018693.2 BC018699.2 BC020972.1 BT009922.1 
    U89896.1 

    15 DOTS entries:

    DT.453974  DT.92436540  DT.421279  DT.121448291  DT.95149982  DT.95149981  DT.100030355  DT.100643000 
    DT.121448293  DT.121448314  DT.92047878  DT.92436538  DT.95093598  DT.100869400  DT.121448267 

    24/345 AceView cDNA sequences (see all 345):

    AW005741 BQ013295 AI870297 AA689422 R59106 BM048132 BX093398 BU621187 
    AA436227 AW974420 AI362914 BQ639056 BU607576 BM810192 AI401712 AI673034 
    BI830106 AA344701 BU859555 BQ059450 BM743282 BF591173 CK820273 CD370088 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G2 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^
    SP1:        -     -     -     -     -                                   -                             -                                                         
    SP2:                                                                    -                             -                                                         
    SP3:                          -     -                                   -                                                                                       
    SP4:        -     -     -     -     -     -     -     -                 -                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CSNK1G2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSNK1G2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGACTTTG
    CSNK1G2 Expression
    About this image


    See CSNK1G2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSNK1G2

    SOURCE GeneReport for Unigene cluster: Hs.651905

    UniProtKB/Swiss-Prot: KC1G2_HUMAN, P78368
    Tissue specificity: Testis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CSNK1G2 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csnk1g21 , 5 casein kinase 1, gamma 21, 5 89.64(n)1
    95.18(a)1
      10 (39.72 cM)5
    1032361  NM_001159591.11  NP_001153063.11 
     806227805 
    chicken
    (Gallus gallus)
    Aves LOC1008578621 casein kinase I isoform gamma-2-like 82.85(n)
    88.92(a)
      100857862  XM_003642863.1  XP_003642911.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSNK1G26
    --
    Uncharacterized protein
    94(a)
    92(a)
    1 ↔ 1
    possible ortholog
    AAWZ02040641(1827-5553)
    AAWZ02037766(6980-14374)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.257862 Xenopus laevis transcribed sequence with moderate similarity more 73.58(n)    CA981309.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK397356.12   -- 81.35(n)    CK397356.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YCK2(YNL154C)4
    YCK11
    Palmitoylated plasma membrane-bound casein kinase I more4
    Yck1p1
    53.47(n)1
    55.7(a)1
      14(345276-343636)4
    8565371  NP_012003.11  8555684 
     NP_014245.14 


    ENSEMBL Gene Tree for CSNK1G2 (if available)
    TreeFam Gene Tree for CSNK1G2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSNK1G2 gene
    VRK32  VRK12  CSNK1G32  VRK22  CSNK1D2  ENSG000002593162  CSNK1A12  CSNK1A1L2  
    TTBK12  CSNK1E2  CSNK1G12  TTBK22  
    8 SIMAP similar genes for CSNK1G2 using alignment to 4 protein entries:     KC1G2_HUMAN (see all proteins):
    CSNK1G3    CSNK1G1    CSNK1E    CSNK1D    CSNK1A1    CSNK1A1L
    ULK1    TTBK1

    CSNK1G2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CSNK1G2
    PGOHUM00000236358


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1173 SNPs in CSNK1G2 are shown (see all 1173)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0420944
    ----see VAR_0420942 T M mis40--------
    VAR_0420914
    ----see VAR_0420912 R S mis40--------
    VAR_0420874
    ----see VAR_0420872 E G mis40--------
    VAR_0420884
    ----see VAR_0420882 I T mis40--------
    VAR_0420894
    ----see VAR_0420892 Y C mis40--------
    VAR_0420934
    ----see VAR_0420932 R C mis40--------
    VAR_0420904
    ----see VAR_0420902 Y H mis40--------
    VAR_0420864
    ----see VAR_0420862 F L mis40--------
    VAR_0420924
    ----see VAR_0420922 E Q mis40--------
    rs1445349231,2
    C--1939248(+) ATAAA-/TAAA  
            
    AACCC
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CSNK1G2 (1941161 - 1981337 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/38 variations for CSNK1G2 (see all 38):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717864CNV Deletion23290073
    nsv820901CNV Deletion20802225
    esv1623717CNV Deletion17803354
    esv2674106CNV Deletion23128226
    esv2717867CNV Deletion23290073
    esv2717857CNV Deletion23290073
    esv2717860CNV Deletion23290073
    esv1678175CNV Deletion17803354
    esv2717858CNV Deletion23290073
    dgv529e201CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602214    OMIM disorders: --

    3 diseases for CSNK1G2:    About MalaCards
    follicular adenoma    febrile seizures    adenoma


    CSNK1G2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CSNK1G2
    Human Genome Epidemiology (HuGE) Navigator: CSNK1G2 (2 documents)

    Export disorders for CSNK1G2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSNK1G2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with CSNK1G2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2). (PubMed id 9403068)1, 2, 3, 9 Kitabayashi A.N.... Hashimoto K. (1997)
    2. Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population. (PubMed id 15342122)1, 2, 4, 9 Yinan M....Xiru W. (2004)
    3. Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. (PubMed id 18794808)1, 2, 9 Guo X....Wang X.F. (2008)
    4. [Five single nucleotide polymorphisms of casein kinase I gamma 2 gene in children with familial febrile convulsions] (PubMed id 15300631)1, 4, 9 Ma Y.N....Qi Y. (2004)
    5. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. (PubMed id 15077195)1, 2, 9 Mishra S.K....Kumar R. (2004)
    6. Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin. (PubMed id 19005213)1, 2 Tomishige N....Hanada K. (2009)
    7. SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. (PubMed id 15917222)1, 2 Shirogane T....Harper J.W. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1455 HGNC: 2455 AceView: CSNK1G2 Ensembl:ENSG00000133275 euGenes: HUgn1455
    ECgene: CSNK1G2 Kegg: 1455 H-InvDB: CSNK1G2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSNK1G2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CSNK1G2 gene:
    Search GeneIP for patents involving CSNK1G2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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