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Aliases for CSNK1G2 Gene

Aliases for CSNK1G2 Gene

  • Casein Kinase 1, Gamma 2 2 3
  • CKI-Gamma 2 3 4
  • EC 2.7.11.1 4 63
  • CK1g2 3 4
  • Casein Kinase 1 Isoform Gamma-2 3
  • Casein Kinase I Isoform Gamma-2 3
  • EC 2.7.11 63

External Ids for CSNK1G2 Gene

Previous GeneCards Identifiers for CSNK1G2 Gene

  • GC19P002032
  • GC19P001881
  • GC19P001892
  • GC19P001920
  • GC19P001713

Summaries for CSNK1G2 Gene

GeneCards Summary for CSNK1G2 Gene

CSNK1G2 (Casein Kinase 1, Gamma 2) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein serine/threonine kinase activity and glycoprotein binding. An important paralog of this gene is CSNK1A1.

UniProtKB/Swiss-Prot for CSNK1G2 Gene

  • Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Tocris Summary for CSNK1G2 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in a number of cellular processes including DNA repair, cell division, nuclear localization and membrane transport. CK1 isoforms also have key roles in the developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor, CK1alpha is thought to phosphorylate beta-catenin as part of its degradation process. Upon binding of Wnt to its receptor (Frizzled) CK1epsilon phosphorylates the intracellular signaling protein, Dishevelled and CK1gamma directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1alpha plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound state, and then when Hh binds to Patched, CK1alpha phosphorylates the 7-TM co-receptor, Smoothened.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1G2 Gene

Genomics for CSNK1G2 Gene

Regulatory Elements for CSNK1G2 Gene

Genomic Location for CSNK1G2 Gene

Start:
1,941,149 bp from pter
End:
1,981,338 bp from pter
Size:
40,190 bases
Orientation:
Plus strand

Genomic View for CSNK1G2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSNK1G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1G2 Gene

Proteins for CSNK1G2 Gene

  • Protein details for CSNK1G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78368-KC1G2_HUMAN
    Recommended name:
    Casein kinase I isoform gamma-2
    Protein Accession:
    P78368
    Secondary Accessions:
    • B5BU42
    • O00704
    • Q8WUB1

    Protein attributes for CSNK1G2 Gene

    Size:
    415 amino acids
    Molecular mass:
    47457 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with MTA1 (short isoform) in the cytoplasm. Interacts with SMAD3.

    Three dimensional structures from OCA and Proteopedia for CSNK1G2 Gene

neXtProt entry for CSNK1G2 Gene

Proteomics data for CSNK1G2 Gene at MOPED

Post-translational modifications for CSNK1G2 Gene

Other Protein References for CSNK1G2 Gene

Domains for CSNK1G2 Gene

Gene Families for CSNK1G2 Gene

Suggested Antigen Peptide Sequences for CSNK1G2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78368

UniProtKB/Swiss-Prot:

KC1G2_HUMAN :
  • P78368
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1G2: view

Function for CSNK1G2 Gene

Molecular function for CSNK1G2 Gene

GENATLAS Biochemistry: casein kinase 1 gamma 2,predominantly expressed in testis,may be involved in signaling pathways downstream of RTKS
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Stimulated by estrogen. Repressed by 5-iodotubercidin (DB04604).
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Enzyme Numbers (IUBMB) for CSNK1G2 Gene

Gene Ontology (GO) - Molecular Function for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0001948 glycoprotein binding IEA --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS 9403068
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with CSNK1G2: view

Phenotypes for CSNK1G2 Gene

genes like me logo Genes that share phenotypes with CSNK1G2: view

miRNA for CSNK1G2 Gene

miRTarBase miRNAs that target CSNK1G2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CSNK1G2 Gene

Localization for CSNK1G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1G2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK1G2 Gene COMPARTMENTS Subcellular localization image for CSNK1G2 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CSNK1G2: view

Pathways for CSNK1G2 Gene

genes like me logo Genes that share pathways with CSNK1G2: view

Pathways by source for CSNK1G2 Gene

1 KEGG pathway for CSNK1G2 Gene
1 GeneGo (Thomson Reuters) pathway for CSNK1G2 Gene
1 Tocris pathway for CSNK1G2 Gene

Gene Ontology (GO) - Biological Process for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 9403068
GO:0006665 sphingolipid metabolic process TAS --
GO:0006897 endocytosis IBA --
GO:0007165 signal transduction TAS 9403068
GO:0008360 regulation of cell shape IBA --
genes like me logo Genes that share ontologies with CSNK1G2: view

Compounds for CSNK1G2 Gene

(5) Tocris Compounds for CSNK1G2 Gene

Compound Action Cas Number
D 4476 Selective CK1 inhibitor. Also inhibits TGF-betaRI [301836-43-1]
LH 846 Selective casein kinase 1delta inhibitor [639052-78-1]
PF 4800567 hydrochloride Selective casein kinase 1eta inhibitor [1391052-28-0]
PF 670462 Potent and selective CK1eta and CK1delta inhibitor [950912-80-8]
TA 02 Induces cardiomyocyte differentiation from hESCs

(2) HMDB Compounds for CSNK1G2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(3) Drugbank Compounds for CSNK1G2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
5-iodotubercidin
24386-93-4 target
IC261
target
N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide
target

(1) Novoseek inferred chemical compound relationships for CSNK1G2 Gene

Compound -log(P) Hits PubMed IDs
serine 28.2 1
genes like me logo Genes that share compounds with CSNK1G2: view

Transcripts for CSNK1G2 Gene

Unigene Clusters for CSNK1G2 Gene

Casein kinase 1, gamma 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^
SP1: - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - - - - - -
SP5:
SP6: -
SP7: - - -
SP8:
SP9: -
SP10: -
SP11: -
SP12: - - - -

ExUns: 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CSNK1G2 Gene

GeneLoc Exon Structure for
CSNK1G2
ECgene alternative splicing isoforms for
CSNK1G2

Expression for CSNK1G2 Gene

mRNA expression in normal human tissues for CSNK1G2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSNK1G2 Gene

SOURCE GeneReport for Unigene cluster for CSNK1G2 Gene Hs.651905

mRNA Expression by UniProt/SwissProt for CSNK1G2 Gene

P78368-KC1G2_HUMAN
Tissue specificity: Testis
genes like me logo Genes that share expressions with CSNK1G2: view

No data available for mRNA differential expression in normal tissues for CSNK1G2 Gene

Orthologs for CSNK1G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSNK1G2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK1G2 35
  • 95.49 (n)
  • 94.37 (a)
CSNK1G2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSNK1G2 35
  • 91.87 (n)
  • 95.89 (a)
CSNK1G2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSNK1G2 35
  • 93.32 (n)
  • 95.17 (a)
CSNK1G2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csnk1g2 35
  • 89.64 (n)
  • 95.18 (a)
Csnk1g2 16
Csnk1g2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSNK1G2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSNK1G2 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csnk1g2 35
  • 90.12 (n)
  • 94.94 (a)
chicken
(Gallus gallus)
Aves CSNK1G2 36
  • 81 (a)
OneToOne
LOC100857862 35
  • 82.85 (n)
  • 88.92 (a)
lizard
(Anolis carolinensis)
Reptilia CSNK1G2 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25786 35
zebrafish
(Danio rerio)
Actinopterygii csnk1g2a 35
  • 78.26 (n)
  • 89.37 (a)
csnk1g2a 36
  • 89 (a)
OneToMany
csnk1g2b 36
  • 83 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta gish 36
  • 56 (a)
OneToMany
gish 37
  • 70 (a)
CG9962 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea csnk-1 35
  • 57.75 (n)
  • 68.05 (a)
csnk-1 36
  • 66 (a)
OneToMany
Y106G6E.6 37
  • 67 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR040W 35
  • 62.75 (n)
  • 58.48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRR25 36
  • 34 (a)
OneToMany
YCK1 35
  • 53.47 (n)
  • 55.7 (a)
YCK2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D11044g 35
  • 50.05 (n)
  • 53.17 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04005 35
  • 61.82 (n)
  • 63.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cki1 35
  • 55.02 (n)
  • 58.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2609 36
  • 71 (a)
OneToMany
Species with no ortholog for CSNK1G2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CSNK1G2 Gene

ENSEMBL:
Gene Tree for CSNK1G2 (if available)
TreeFam:
Gene Tree for CSNK1G2 (if available)

Paralogs for CSNK1G2 Gene

Selected SIMAP similar genes for CSNK1G2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CSNK1G2 Gene

genes like me logo Genes that share paralogs with CSNK1G2: view

Variants for CSNK1G2 Gene

Sequence variations from dbSNP and Humsavar for CSNK1G2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs740051 -- 1,977,429(+) TGGCC(G/T)CCTCC intron-variant
rs740423 -- 1,978,272(-) CCAGC(A/G)CAGGG intron-variant
rs744385 -- 1,947,777(+) CGTGC(C/T)GTGCC intron-variant
rs878439 -- 1,943,974(-) CCCAC(C/T)GCCAC intron-variant
rs878440 -- 1,943,854(-) GACGG(A/C)CCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK1G2 Gene

Variant ID Type Subtype PubMed ID
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
dgv3613n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
nsv470107 CNV Loss 18288195
nsv910569 CNV Loss 21882294
nsv910587 CNV Gain+Loss 21882294
nsv910588 CNV Loss 21882294
nsv910589 CNV Gain+Loss 21882294
dgv3621n71 CNV Loss 21882294
nsv910593 CNV Loss 21882294
esv2661504 CNV Deletion 23128226
dgv568n67 CNV Gain 20364138
nsv820901 CNV Deletion 20802225
esv2717856 CNV Deletion 23290073
nsv828388 CNV Gain 20364138
esv2657128 CNV Deletion 23128226
esv26747 CNV Gain+Loss 19812545
esv2717857 CNV Deletion 23290073
esv2717858 CNV Deletion 23290073
esv989730 CNV Deletion 20482838
esv2717859 CNV Deletion 23290073
esv1678175 CNV Deletion 17803354
esv2717860 CNV Deletion 23290073
esv2674106 CNV Deletion 23128226
dgv529e201 CNV Deletion 23290073
esv2717863 CNV Deletion 23290073
esv2717864 CNV Deletion 23290073
esv1623717 CNV Deletion 17803354
nsv910594 CNV Loss 21882294
dgv3622n71 CNV Loss 21882294
esv2717866 CNV Deletion 23290073
esv2717867 CNV Deletion 23290073
nsv138132 CNV Insertion 16902084
dgv3623n71 CNV Loss 21882294
esv2669669 CNV Deletion 23128226

Relevant External Links for CSNK1G2 Gene

HapMap Linkage Disequilibrium report
CSNK1G2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1G2 Gene

Disorders for CSNK1G2 Gene

Relevant External Links for CSNK1G2

Genetic Association Database (GAD)
CSNK1G2
Human Genome Epidemiology (HuGE) Navigator
CSNK1G2
genes like me logo Genes that share disorders with CSNK1G2: view

No data available for UniProtKB/Swiss-Prot for CSNK1G2 Gene

Publications for CSNK1G2 Gene

  1. Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population. (PMID: 15342122) Yinan M. … Xiru W. (Neurosci. Lett. 2004) 3 4 23 48
  2. Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2). (PMID: 9403068) Kitabayashi A.N. … Hashimoto K. (Genomics 1997) 2 3 4 23
  3. Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. (PMID: 18794808) Guo X. … Wang X.-F. (Oncogene 2008) 3 4 23
  4. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. (PMID: 15077195) Mishra S.K. … Kumar R. (Oncogene 2004) 3 4 23
  5. [Five single nucleotide polymorphisms of casein kinase I gamma 2 gene in children with familial febrile convulsions]. (PMID: 15300631) Ma Y.N. … Qi Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004) 3 23 48

Products for CSNK1G2 Gene

Sources for CSNK1G2 Gene

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