CSNK1G2 Gene
protein-coding GIFtS: 65
GCID: GC19P001941
|
|
casein kinase 1, gamma 2
| |
Aliases
for CSNK1G2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Casein Kinase 1, Gamma 21 2 | | Casein Kinase 1 Isoform Gamma-22 | | CK1g21 2 | | Casein Kinase I Isoform Gamma-22 | | CKI-Gamma 22 3 | | CK1G23 | | EC 2.7.11.13 8 | | EC 2.7.118 |
Export aliases for CSNK1G2 gene to outside databasesPrevious GC identifers: GC19P002032 GC19P001881 GC19P001892 GC19P001920 GC19P001713 |
Summaries
for CSNK1G2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KC1G2_HUMAN, P78368Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilizationof acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wntsignaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesiculartrafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediatedby glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasomedegradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif ofCOL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgitransport of ceramide and sphingomyelin synthesis
 summary
for CSNK1G2: Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1,
gamma2, gamma3, delta and epsilon. CK1 is involved in a number of cellular processes including DNA repair,
cell division, nuclear localization and membrane transport. CK1 isoforms also have key roles in the
developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor,
CK1alpha is thought to phosphorylate beta-catenin as part of its degradation process. Upon binding of Wnt to
its receptor (Frizzled) CK1epsilon phosphorylates the intracellular signaling protein, Dishevelled and
CK1gamma directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction
to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1alpha
plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound
state, and then when Hh binds to Patched, CK1alpha phosphorylates the 7-TM co-receptor, Smoothened.
|
Genomic Views
for CSNK1G2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CSNK1G2 gene promoter:
USF1 SREBP-1c USF2 USF-1:USF-2 GATA-1 SREBP-1b SREBP-1a USF-1 c-Myb Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for CSNK1G2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK1G2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3CSNK1G2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P001941: view genomic region
(about GC identifiers)
Start:
|
1,941,161 bp from pter |
End:
|
1,981,337 bp from pter |
Size:
|
40,177 bases |
Orientation:
|
plus strand |
|
Proteins
for CSNK1G2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KC1G2_HUMAN, P78368 (See
protein sequence)Recommended Name: Casein kinase I isoform gamma-2 Size: 415 amino acids; 47457 Da
Subunit: Monomer (By similarity). Interacts with MTA1 (short isoform) in the cytoplasm. Binds to PER1 and triggers itsproteasomal degradation. Interacts with SMAD3
Subcellular location: Cytoplasm
1 PDB 3D structure from  and Proteopedia  for CSNK1G2:2C47 (3D)
Secondary accessions: B5BU42 O00704 Q8WUB1Explore the universe of human proteins at neXtProt for CSNK1G2: NX_P78368
Post-translational modifications:
Autophosphorylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P78368
4/17 DME Specific Peptides for CSNK1G2 (P78368) (see all 17)
CSNK1G2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001310.3
ENSEMBL proteins: ENSP00000255641 ENSP00000467214 ENSP00000465106 ENSP00000468637 Reactome Protein details: P78368
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CSNK1G2 for ontologies About GeneDecksing
CSNK1G2 Antibody Products:
Assay Products for CSNK1G2: |
Protein
Domains /
Families
for CSNK1G2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CSNK1G2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P78368ProtoNet protein and cluster: P78368 UniProtKB/Swiss-Prot: KC1G2_HUMAN, P78368Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamilySimilarity: Contains 1 protein kinase domain |
Function
for CSNK1G2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KC1G2_HUMAN, P78368Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilizationof acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wntsignaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesiculartrafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediatedby glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasomedegradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif ofCOL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgitransport of ceramide and sphingomyelin synthesisCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Stimulated by estrogen. Repressed by 5-iodotubercidin (DB04604) Genatlas biochemistry entry for CSNK1G2:casein kinase 1 gamma 2,predominantly expressed in testis,may be involved in signaling pathways downstream of RTKS
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1G2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1G2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CSNK1G2 (NM_001319) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CSNK1G2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1G2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1G2 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
CSNK1G2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for CSNK1G2:
|
Pathways & Interactions
for CSNK1G2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sphingolipid metabolism | | | 2 | Metabolism | | | 3 | Development_CNTF receptor signaling | | | 4 | WNT Signaling | | | 5 | Signaling in Gap Junctions | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CSNK1G2
5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSNK1G2
1 Tocris Bioscience Pathway for CSNK1G2
1  GeneGo (Thomson Reuters) Pathway for CSNK1G2
3  BioSystems Pathways for CSNK1G2
4 
Reactome Pathways for CSNK1G2
1 
Kegg Pathway (Kegg details for CSNK1G2):
CSNK1G2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CSNK1G2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/100 Interacting proteins for CSNK1G2 (P783682, 3 ENSP000002556414) via UniProtKB, MINT, STRING, and/or I2D (see all 100)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
CSNK1G2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CSNK1G2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CSNK1G2 for compounds About GeneDecksing
Compounds for CSNK1G2 available from Tocris Bioscience About this table
2 HMDB Compounds for CSNK1G2 About this table
3 DrugBank Compounds for CSNK1G2 About this table
1 Novoseek chemical compound relationship for CSNK1G2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| serine |
28.2 |
1 |
10409710 (1) |
Search CenterWatch for drugs/clinical trials and news about CSNK1G2 / KC1G2
|
Transcripts
for CSNK1G2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CSNK1G2 gene: NM_001319.6 Unigene Cluster for CSNK1G2: Casein kinase 1, gamma 2 Hs.651905 [show with all ESTs]Unigene Representative Sequence: NM_00131910 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000255641(uc002lul.4 uc010dsu.3) ENST00000587123 ENST00000591752
ENST00000589350 ENST00000589385 ENST00000591002 ENST00000585959 ENST00000590106
ENST00000585957 ENST00000589861
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1G2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1G2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CSNK1G2 (NM_001319) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CSNK1G2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1G2 |
Additional cDNA sequence: AB451278.1 AB451410.1 AF001177.1 AY007134.1 BC018693.2 BC018699.2 BC020972.1 BT009922.1 U89896.1 15 DOTS entries: DT.453974 DT.92436540 DT.421279 DT.121448291 DT.95149982 DT.95149981 DT.100030355 DT.100643000 DT.121448293 DT.121448314 DT.92047878 DT.92436538 DT.95093598 DT.100869400 DT.121448267 24/345 AceView cDNA sequences (see all 345): BG178730 AI916075 BF590743 BM561324 BI911256 AW001370 BM725062 AA936613 BU173957 AW873011 AI401712 AI873325 BM695823 BQ013295 CA310779 CK820273 BM743456 AI570365 BQ639056 CD611289 BM969429 BE313914 CB241824 AI698541
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G2 (see all 12) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15 | ^ |
|---|
|
| SP1: | | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16a | · | 16b |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for CSNK1G2
|
Expression
for CSNK1G2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CSNK1G2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGACTTTG
About this image
See CSNK1G2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CSNK1G2
SOURCE GeneReport for Unigene cluster: Hs.651905
UniProtKB/Swiss-Prot: KC1G2_HUMAN, P78368Tissue specificity: Testis
SABiosciences Custom PCR Arrays for CSNK1G2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSNK1G2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSNK1G2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSNK1G2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSNK1G2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1G2 |
Orthologs
for CSNK1G2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for CSNK1G2 gene from 7/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008578621 |
casein kinase I isoform gamma-2-like |
82.85(n)
88.92(a) |
|
100857862 XM_003642863.1 XP_003642911.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CSNK1G26-- |
-- |
94(a)91(a) |
possible orthologpossible ortholog |
AAWZ02040641(1861-3853) AAWZ02037766(6980-14305) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.257862 |
Xenopus laevis transcribed sequence with moderate similarity more |
73.58(n) |
|
CA981309.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CK397356.12 |
-- |
81.35(n) |
|
CK397356.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
gish3 |
glia cell migration casein kinase I |
70(a)
(best of 2) |
|
89B17 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y106G6E.63 |
casein kinase like |
67(a) |
|
I(10236146-10237779) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
YCK2(YNL154C)4
YCK11 |
Palmitoylated plasma membrane-bound casein kinase I more4
Yck1p1 |
53.47(n)1
55.7(a)1 |
|
14(345276-343636)4
8565371 NP_012003.11 8555684
NP_014245.14 |
ENSEMBL Gene Tree for CSNK1G2 (if available)
TreeFam Gene Tree for CSNK1G2 (if available) |
Paralogs
for CSNK1G2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CSNK1G2 gene
- VRK32 VRK12 CSNK1G32 VRK22 CSNK1D2 CSNK1A12 CSNK1A1L2 TTBK12
- CSNK1G12 CSNK1E2 TTBK22
8 SIMAP similar genes for CSNK1G2 using alignment to 4 protein entries: KC1G2_HUMAN (see all proteins):CSNK1G3 CSNK1G1 CSNK1E CSNK1D CSNK1A1 CSNK1A1L
ULK1 TTBK1
CSNK1G2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CSNK1G2
PGOHUM00000236358
|
Genomic Variants
for CSNK1G2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CSNK1G2 (1941161 - 1981337 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for CSNK1G2
4 CNVs: 30062 7191 30063 73278
2 Indels: 26206 26208 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSNK1G2 |
|
Disorders
/ Diseases
for CSNK1G2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CSNK1G2 for disorders About GeneDecksing
OMIM gene information: 602214
OMIM disorders: --
6  diseases for CSNK1G2: About MalaCardsfebrile convulsions febrile seizures convulsions follicular adenoma
seizures adenoma
Genetic Association Database (GAD): CSNK1G2
Human Genome Epidemiology (HuGE) Navigator: CSNK1G2 (2 documents)
Export disorders for CSNK1G2 gene to outside databases
|
Publications
for CSNK1G2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CSNK1G2 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with CSNK1G2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2). (PubMed id 9403068)1, 2, 3, 9 Kitabayashi A.N.... Hashimoto K. (1997)
- Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population. (PubMed id 15342122)1, 2, 4, 9 Yinan M....Xiru W. (2004)
- Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. (PubMed id 18794808)1, 2, 9 Guo X....Wang X.F. (2008)
- [Five single nucleotide polymorphisms of casein kinase I gamma 2 gene in children with familial febrile convulsions] (PubMed id 15300631)1, 4, 9 Ma Y.N....Qi Y. (2004)
- Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. (PubMed id 15077195)1, 2, 9 Mishra S.K....Kumar R. (2004)
- Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin. (PubMed id 19005213)1, 2 Tomishige N....Hanada K. (2009)
- SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. (PubMed id 15917222)1, 2 Shirogane T....Harper J.W. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
|
External Searches for CSNK1G2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CSNK1G2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CSNK1G2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CSNK1G2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CSNK1G2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CSNK1G2 gene:
Search GeneIP for patents involving CSNK1G2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CSNK1G2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CSNK1G2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSNK1G2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSNK1G2 | | | OriGene Protein Over-expression Lysate for CSNK1G2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CSNK1G2 | | OriGene 3'-UTR Clone for CSNK1G2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1G2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1G2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CSNK1G2 | | OriGene Custom Protein Services for CSNK1G2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CSNK1G2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSNK1G2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK1G2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSNK1G2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSNK1G2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSNK1G2 |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1G2 |
|  |  |  | | | | ThermoFisher Antibodies for CSNK1G2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1G2 |
|
|
|
|
