Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CSNK1G2 Gene

Aliases for CSNK1G2 Gene

  • Casein Kinase 1 Gamma 2 2 3
  • Casein Kinase 1, Gamma 2 2 3 5
  • CKI-Gamma 2 3 4
  • EC 2.7.11.1 4 63
  • CK1g2 3 4
  • Casein Kinase 1 Isoform Gamma-2 3
  • EC 2.7.11 63

External Ids for CSNK1G2 Gene

Previous GeneCards Identifiers for CSNK1G2 Gene

  • GC19P002032
  • GC19P001881
  • GC19P001892
  • GC19P001920
  • GC19P001713

Summaries for CSNK1G2 Gene

GeneCards Summary for CSNK1G2 Gene

CSNK1G2 (Casein Kinase 1 Gamma 2) is a Protein Coding gene. Among its related pathways are Basal cell carcinoma and Hedgehog Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1A1.

UniProtKB/Swiss-Prot for CSNK1G2 Gene

  • Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Tocris Summary for CSNK1G2 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1G2 Gene

Genomics for CSNK1G2 Gene

Regulatory Elements for CSNK1G2 Gene

Enhancers for CSNK1G2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CSNK1G2 on UCSC Golden Path with GeneCards custom track

Promoters for CSNK1G2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CSNK1G2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CSNK1G2 Gene

Chromosome:
19
Start:
1,941,149 bp from pter
End:
1,981,338 bp from pter
Size:
40,190 bases
Orientation:
Plus strand

Genomic View for CSNK1G2 Gene

Genes around CSNK1G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1G2 Gene

Proteins for CSNK1G2 Gene

  • Protein details for CSNK1G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78368-KC1G2_HUMAN
    Recommended name:
    Casein kinase I isoform gamma-2
    Protein Accession:
    P78368
    Secondary Accessions:
    • B5BU42
    • O00704
    • Q8WUB1

    Protein attributes for CSNK1G2 Gene

    Size:
    415 amino acids
    Molecular mass:
    47457 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with MTA1 (short isoform) in the cytoplasm. Interacts with SMAD3.

    Three dimensional structures from OCA and Proteopedia for CSNK1G2 Gene

neXtProt entry for CSNK1G2 Gene

Proteomics data for CSNK1G2 Gene at MOPED

Post-translational modifications for CSNK1G2 Gene

Domains & Families for CSNK1G2 Gene

Gene Families for CSNK1G2 Gene

Suggested Antigen Peptide Sequences for CSNK1G2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78368

UniProtKB/Swiss-Prot:

KC1G2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1G2: view

Function for CSNK1G2 Gene

Molecular function for CSNK1G2 Gene

GENATLAS Biochemistry:
casein kinase 1 gamma 2,predominantly expressed in testis,may be involved in signaling pathways downstream of RTKS
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by estrogen. Repressed by 5-iodotubercidin (DB04604).
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Enzyme Numbers (IUBMB) for CSNK1G2 Gene

Gene Ontology (GO) - Molecular Function for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
genes like me logo Genes that share ontologies with CSNK1G2: view
genes like me logo Genes that share phenotypes with CSNK1G2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSNK1G2 Gene

Localization for CSNK1G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1G2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK1G2 Gene COMPARTMENTS Subcellular localization image for CSNK1G2 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CSNK1G2: view

Pathways & Interactions for CSNK1G2 Gene

genes like me logo Genes that share pathways with CSNK1G2: view

Pathways by source for CSNK1G2 Gene

SIGNOR curated interactions for CSNK1G2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9403068
GO:0008360 regulation of cell shape IBA --
GO:0018105 peptidyl-serine phosphorylation IDA 25500533
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0046777 protein autophosphorylation IEA --
genes like me logo Genes that share ontologies with CSNK1G2: view

Drugs & Compounds for CSNK1G2 Gene

(6) Drugs for CSNK1G2 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
5-iodotubercidin Experimental Pharma Target Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases 0
IC261 Experimental Pharma Target 0
N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide Experimental Pharma Target 0
TAK-715 Pharma p38 MAPK inhibitor, Potent p38 MAPK inhibitor; anti-inflammatory 0

(5) Additional Compounds for CSNK1G2 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
(R)-CR8
294646-77-8
(R)-DRF053 dihydrochloride
1241675-76-2
D 4476
301836-43-1
PF 670462
950912-80-8

(5) Tocris Compounds for CSNK1G2 Gene

Compound Action Cas Number
(R)-CR8 Dual cdk1/cdk5 inhibitor; also inhibits CK1 294646-77-8
(R)-DRF053 dihydrochloride Dual CK1/cdk inhibitor 1241675-76-2
D 4476 Selective CK1 inhibitor. Also inhibits TGF-betaRI 301836-43-1
PF 670462 Potent and selective CK1epsilon and CK1delta inhibitor 950912-80-8
TAK 715 Potent p38 MAPK inhibitor; anti-inflammatory 303162-79-0
genes like me logo Genes that share compounds with CSNK1G2: view

Transcripts for CSNK1G2 Gene

Unigene Clusters for CSNK1G2 Gene

Casein kinase 1, gamma 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^
SP1: - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - - - - - -
SP5:
SP6: -
SP7: - - -
SP8:
SP9: -
SP10: -
SP11: -
SP12: - - - -

ExUns: 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CSNK1G2 Gene

GeneLoc Exon Structure for
CSNK1G2
ECgene alternative splicing isoforms for
CSNK1G2

Expression for CSNK1G2 Gene

mRNA expression in normal human tissues for CSNK1G2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSNK1G2 Gene

This gene is overexpressed in Placenta (23.5), Spleen (17.4), Spinal cord (11.9), and CD8 Tcells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSNK1G2 Gene



SOURCE GeneReport for Unigene cluster for CSNK1G2 Gene Hs.651905

mRNA Expression by UniProt/SwissProt for CSNK1G2 Gene

P78368-KC1G2_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with CSNK1G2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CSNK1G2 Gene

Orthologs for CSNK1G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSNK1G2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSNK1G2 35
  • 91.87 (n)
  • 95.89 (a)
CSNK1G2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSNK1G2 35
  • 93.32 (n)
  • 95.17 (a)
CSNK1G2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csnk1g2 35
  • 89.64 (n)
  • 95.18 (a)
Csnk1g2 16
Csnk1g2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSNK1G2 35
  • 95.49 (n)
  • 94.37 (a)
CSNK1G2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csnk1g2 35
  • 90.12 (n)
  • 94.94 (a)
oppossum
(Monodelphis domestica)
Mammalia CSNK1G2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSNK1G2 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857862 35
  • 82.85 (n)
  • 88.92 (a)
CSNK1G2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSNK1G2 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25786 35
zebrafish
(Danio rerio)
Actinopterygii csnk1g2a 35
  • 78.26 (n)
  • 89.37 (a)
csnk1g2a 36
  • 89 (a)
OneToMany
csnk1g2b 36
  • 83 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9962 37
  • 42 (a)
gish 37
  • 70 (a)
gish 36
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y106G6E.6 37
  • 67 (a)
csnk-1 35
  • 57.75 (n)
  • 68.05 (a)
csnk-1 36
  • 66 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR040W 35
  • 62.75 (n)
  • 58.48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D11044g 35
  • 50.05 (n)
  • 53.17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCK1 35
  • 53.47 (n)
  • 55.7 (a)
HRR25 36
  • 34 (a)
OneToMany
YCK2 38
bread mold
(Neurospora crassa)
Ascomycetes NCU04005 35
  • 61.82 (n)
  • 63.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cki1 35
  • 55.02 (n)
  • 58.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2609 36
  • 71 (a)
OneToMany
Species with no ortholog for CSNK1G2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CSNK1G2 Gene

ENSEMBL:
Gene Tree for CSNK1G2 (if available)
TreeFam:
Gene Tree for CSNK1G2 (if available)

Paralogs for CSNK1G2 Gene

(8) SIMAP similar genes for CSNK1G2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CSNK1G2 Gene

genes like me logo Genes that share paralogs with CSNK1G2: view

Variants for CSNK1G2 Gene

Sequence variations from dbSNP and Humsavar for CSNK1G2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_042086 -
VAR_042087 -
VAR_042088 -
VAR_042089 -
VAR_042090 -

Structural Variations from Database of Genomic Variants (DGV) for CSNK1G2 Gene

Variant ID Type Subtype PubMed ID
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
dgv3613n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
nsv470107 CNV Loss 18288195
nsv910569 CNV Loss 21882294
nsv910587 CNV Gain+Loss 21882294
nsv910588 CNV Loss 21882294
nsv910589 CNV Gain+Loss 21882294
dgv3621n71 CNV Loss 21882294
nsv910593 CNV Loss 21882294
esv2661504 CNV Deletion 23128226
dgv568n67 CNV Gain 20364138
nsv820901 CNV Deletion 20802225
esv2717856 CNV Deletion 23290073
nsv828388 CNV Gain 20364138
esv2657128 CNV Deletion 23128226
esv26747 CNV Gain+Loss 19812545
esv2717857 CNV Deletion 23290073
esv2717858 CNV Deletion 23290073
esv989730 CNV Deletion 20482838
esv2717859 CNV Deletion 23290073
esv1678175 CNV Deletion 17803354
esv2717860 CNV Deletion 23290073
esv2674106 CNV Deletion 23128226
dgv529e201 CNV Deletion 23290073
esv2717863 CNV Deletion 23290073
esv2717864 CNV Deletion 23290073
esv1623717 CNV Deletion 17803354
nsv910594 CNV Loss 21882294
dgv3622n71 CNV Loss 21882294
esv2717866 CNV Deletion 23290073
esv2717867 CNV Deletion 23290073
nsv138132 CNV Insertion 16902084
dgv3623n71 CNV Loss 21882294
esv2669669 CNV Deletion 23128226

Variation tolerance for CSNK1G2 Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK1G2 Gene

HapMap Linkage Disequilibrium report
CSNK1G2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1G2 Gene

Disorders for CSNK1G2 Gene

Relevant External Links for CSNK1G2

Genetic Association Database (GAD)
CSNK1G2
Human Genome Epidemiology (HuGE) Navigator
CSNK1G2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK1G2

No disorders were found for CSNK1G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK1G2 Gene

Publications for CSNK1G2 Gene

  1. Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2). (PMID: 9403068) Kitabayashi A.N. … Hashimoto K. (Genomics 1997) 2 3 4 23 67
  2. Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. (PMID: 18794808) Guo X. … Wang X.-F. (Oncogene 2008) 3 23
  3. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. (PMID: 15077195) Mishra S.K. … Kumar R. (Oncogene 2004) 3 23
  4. [Five single nucleotide polymorphisms of casein kinase I gamma 2 gene in children with familial febrile convulsions]. (PMID: 15300631) Ma Y.N. … Qi Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004) 3 23
  5. Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population. (PMID: 15342122) Yinan M. … Xiru W. (Neurosci. Lett. 2004) 3 23

Products for CSNK1G2 Gene

Sources for CSNK1G2 Gene

Content