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CSNK1G2 Gene(Protein Coding)

Casein Kinase 1 Gamma 2

GCID:
GC19P001941
GIFtS:
64
Genes Participants
UDN Logo

Aliases for CSNK1G2 Gene

Aliases for CSNK1G2 Gene

  • Casein Kinase 1 Gamma 2 2 3 5
  • CKI-Gamma 2 3 4
  • EC 2.7.11.1 4 61
  • CK1g2 3 4
  • Casein Kinase 1 Isoform Gamma-2 3
  • Casein Kinase I Isoform Gamma-2 3
  • Casein Kinase 1, Gamma 2 2
  • Casein Kinase I 3
  • EC 2.7.11 61

External Ids for CSNK1G2 Gene

Previous GeneCards Identifiers for CSNK1G2 Gene

  • GC19P002032
  • GC19P001881
  • GC19P001892
  • GC19P001920
  • GC19P001713

Summaries for CSNK1G2 Gene

GeneCards Summary for CSNK1G2 Gene

CSNK1G2 (Casein Kinase 1 Gamma 2) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and GPCR Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G3.

UniProtKB/Swiss-Prot for CSNK1G2 Gene

  • Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Tocris Summary for CSNK1G2 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1G2 Gene

Genomics for CSNK1G2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CSNK1G2 Gene

Enhancers for CSNK1G2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G001939 1.8 FANTOM5 ENCODE dbSUPER 14.4 +0.9 869 5.4 HDGF CREB3L1 MLX AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 KLF16 CSNK1G2 ZNF555 SF3A2 BTBD2 CSNK1G2-AS1 C19orf35 ENSG00000267283 REXO1 LOC105372239
GH19G002079 1.8 FANTOM5 ENCODE dbSUPER 10.9 +147.7 147704 18.9 CREB3L1 MLX AGO1 DMAP1 YBX1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SF3A2 BTBD2 CIRBP MKNK2 ZNF77 C19orf24 ENSG00000268798 SCAMP4 RPS15 MOB3A
GH19G002038 2.2 FANTOM5 Ensembl ENCODE dbSUPER 7.2 +109.9 109877 24.2 CREB3L1 MLX AGO1 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SF3A2 LOC100288123 MKNK2 ZNF77 BTBD2 ENSG00000268798 CIRBP PLK5 RPS15 C19orf35
GH19G002160 1.8 FANTOM5 ENCODE dbSUPER 7 +226.6 226592 13.7 CREB3L1 MLX ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 SP3 ZNF77 SF3A2 LOC100288123 CIRBP GADD45B ENSG00000267139 DOT1L ENSG00000267317 ZNF554 ADAT3
GH19G001928 1.5 Ensembl ENCODE dbSUPER 7.6 -11.4 -11360 1.7 PKNOX1 AGO1 ZNF133 ARID4B SIN3A ZNF2 ZNF48 GLIS2 ZNF766 ZNF207 BTBD2 TMEM259 SF3A2 REXO1 KLF16 ATP8B3 LOC100288123 ENSG00000267317 CSNK1G2 SCAMP4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CSNK1G2 on UCSC Golden Path with GeneCards custom track

Promoters for CSNK1G2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105775 451 2801 HDGF CREB3L1 MLX AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766

Transcription factor binding sites by QIAGEN in the CSNK1G2 gene promoter:

Genomic Location for CSNK1G2 Gene

Chromosome:
19
Start:
1,941,149 bp from pter
End:
1,981,338 bp from pter
Size:
40,190 bases
Orientation:
Plus strand

Genomic View for CSNK1G2 Gene

Genes around CSNK1G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1G2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CSNK1G2 Gene

Proteins for CSNK1G2 Gene

Products:

  1. Antibody
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  3. Assay

  • Protein details for CSNK1G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78368-KC1G2_HUMAN
    Recommended name:
    Casein kinase I isoform gamma-2
    Protein Accession:
    P78368
    Secondary Accessions:
    • B5BU42
    • O00704
    • Q8WUB1

    Protein attributes for CSNK1G2 Gene

    Size:
    415 amino acids
    Molecular mass:
    47457 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with MTA1 (short isoform) in the cytoplasm. Interacts with SMAD3.

    Three dimensional structures from OCA and Proteopedia for CSNK1G2 Gene

neXtProt entry for CSNK1G2 Gene

Protein Expression for CSNK1G2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CSNK1G2 Gene

P78368:
  • SSGVLMVGPNFRVGKKIGCGNFGEL
  • LIYRDVKPENFL
  • LCENFPEEM
  • TYLRYVRRLDFFEKPDY
  • KSRAPQLHLEYRFYK
  • SNAPITA
  • FDYEYDW
  • LKTVLMIAIQL
  • EQSRRDDLE
  • LTGTARY
  • LPWQGLKA
  • LGKNLYTNEYVAIKLEP
  • GTARYMSINTH
  • TPIEVLC
  • CCCFFKR
  • LLGPSLEDLF
  • IIDFGLA

Post-translational modifications for CSNK1G2 Gene

Other Protein References for CSNK1G2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CSNK1G2 Gene

Gene Families for CSNK1G2 Gene

IUPHAR :

Protein Domains for CSNK1G2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CSNK1G2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78368

UniProtKB/Swiss-Prot:

KC1G2_HUMAN :
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1G2: view

Function for CSNK1G2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CSNK1G2 Gene

GENATLAS Biochemistry:
casein kinase 1 gamma 2,predominantly expressed in testis,may be involved in signaling pathways downstream of RTKS
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by estrogen. Repressed by 5-iodotubercidin (DB04604).
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Enzyme Numbers (IUBMB) for CSNK1G2 Gene

Gene Ontology (GO) - Molecular Function for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0001948 glycoprotein binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS,IEA 9403068
GO:0005515 protein binding IPI 15917222
genes like me logo Genes that share ontologies with CSNK1G2: view
genes like me logo Genes that share phenotypes with CSNK1G2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSNK1G2 Gene

Localization for CSNK1G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1G2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1G2 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CSNK1G2: view

Pathways & Interactions for CSNK1G2 Gene

genes like me logo Genes that share pathways with CSNK1G2: view

SIGNOR curated interactions for CSNK1G2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS,IEA 9403068
GO:0006897 endocytosis IBA --
GO:0007165 signal transduction TAS 9403068
GO:0008360 regulation of cell shape IBA --
GO:0016055 Wnt signaling pathway IEA,IBA --
genes like me logo Genes that share ontologies with CSNK1G2: view

Drugs & Compounds for CSNK1G2 Gene

Products:

  1. Drug

(10) Drugs for CSNK1G2 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
5-iodotubercidin Experimental Pharma Target Adenosine kinase inhibitor,potent, Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases 0
IC261 Experimental Pharma Target 0
N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide Experimental Pharma Target 0
CKI 7 dihydrochloride Pharma CK1 inhibitor 0

(1) Additional Compounds for CSNK1G2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0

(5) Tocris Compounds for CSNK1G2 Gene

Compound Action Cas Number
CKI 7 dihydrochloride CK1 inhibitor 1177141-67-1
D 4476 Selective CK1 inhibitor. Also inhibits TGF-betaRI 301836-43-1
LH 846 Selective casein kinase 1delta inhibitor 639052-78-1
PF 4800567 hydrochloride Selective casein kinase 1eta inhibitor 1391052-28-0
PF 670462 Potent and selective CK1eta and CK1delta inhibitor 950912-80-8

(1) ApexBio Compounds for CSNK1G2 Gene

Compound Action Cas Number
CKI 7 dihydrochloride 1177141-67-1
genes like me logo Genes that share compounds with CSNK1G2: view

Transcripts for CSNK1G2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CSNK1G2 Gene

(7) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(345) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSNK1G2 Gene

Casein kinase 1, gamma 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^
SP1: - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - - - - - -
SP5:
SP6: -
SP7: - - -
SP8:
SP9: -
SP10: -
SP11: -
SP12: - - - -

ExUns: 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CSNK1G2 Gene

GeneLoc Exon Structure for
CSNK1G2
ECgene alternative splicing isoforms for
CSNK1G2

Expression for CSNK1G2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSNK1G2 Gene

mRNA expression in normal human tissues for CSNK1G2 Gene
mRNA expression by BioGPS for CSNK1G2 GenemRNA expression by GTEx for CSNK1G2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSNK1G2 Gene

This gene is overexpressed in Placenta (23.5), Spleen (17.4), Spinal cord (11.9), and CD8 Tcells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSNK1G2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CSNK1G2 Gene:

CSNK1G2

SOURCE GeneReport for Unigene cluster for CSNK1G2 Gene:

Hs.651905

mRNA Expression by UniProt/SwissProt for CSNK1G2 Gene:

P78368-KC1G2_HUMAN
Tissue specificity: Testis.

Evidence on tissue expression from TISSUES for CSNK1G2 Gene

  • Intestine(4.3)
  • Muscle(4.2)
  • Nervous system(2.6)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with CSNK1G2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1G2 Gene

Orthologs for CSNK1G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSNK1G2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CSNK1G2 34 35
  • 95.49 (n)
dog
(Canis familiaris)
 Mammalia CSNK1G2 34 35
  • 93.32 (n)
cow
(Bos Taurus)
 Mammalia CSNK1G2 34 35
  • 91.87 (n)
rat
(Rattus norvegicus)
 Mammalia Csnk1g2 34
  • 90.12 (n)
mouse
(Mus musculus)
 Mammalia Csnk1g2 34 16 35
  • 89.64 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CSNK1G2 35
  • 83 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CSNK1G2 35
  • 82 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LOC100857862 34
  • 82.85 (n)
CSNK1G2 35
  • 81 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CSNK1G2 35
  • 94 (a)
 OneToOne
African clawed frog
(Xenopus laevis)
 Amphibia Xl.25786 34
zebrafish
(Danio rerio)
 Actinopterygii csnk1g2b 35
  • 83 (a)
 OneToMany
csnk1g2a 34 35
  • 78.26 (n)
fruit fly
(Drosophila melanogaster)
 Insecta gish 36 35
  • 70 (a)
CG9962 36
  • 42 (a)
worm
(Caenorhabditis elegans)
 Secernentea Y106G6E.6 36
  • 67 (a)
csnk-1 34 35
  • 57.75 (n)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AFR040W 34
  • 62.75 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes YCK1 34
  • 53.47 (n)
HRR25 35
  • 34 (a)
 OneToMany
YCK2 37
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D11044g 34
  • 50.05 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.2609 35
  • 71 (a)
 OneToMany
bread mold
(Neurospora crassa)
 Ascomycetes NCU04005 34
  • 61.82 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes cki1 34
  • 55.02 (n)
Species where no ortholog for CSNK1G2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CSNK1G2 Gene

ENSEMBL:
Gene Tree for CSNK1G2 (if available)
TreeFam:
Gene Tree for CSNK1G2 (if available)

Paralogs for CSNK1G2 Gene

Paralogs for CSNK1G2 Gene

(8) SIMAP similar genes for CSNK1G2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CSNK1G2 Gene

genes like me logo Genes that share paralogs with CSNK1G2: view

Variants for CSNK1G2 Gene

Sequence variations from dbSNP and Humsavar for CSNK1G2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000019331 -- 1,953,753(+) AGCTG(C/G)CATTG intron-variant, upstream-variant-2KB
rs1000085525 -- 1,980,937(+) CTGCG(A/C/T)CCCGG nc-transcript-variant, utr-variant-3-prime
rs1000107196 -- 1,953,597(+) TGTCC(A/G)GTGCT intron-variant, upstream-variant-2KB
rs1000117357 -- 1,975,069(+) CAGCC(A/G)CACAC intron-variant
rs1000145273 -- 1,957,052(+) TCGTG(A/C/T)CCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK1G2 Gene

Variant ID Type Subtype PubMed ID
dgv488e201 CNV deletion 23290073
dgv568n67 CNV gain 20364138
dgv6212n54 CNV loss 21841781
dgv6213n54 CNV loss 21841781
dgv6214n54 CNV loss 21841781
esv1623717 CNV deletion 17803354
esv1678175 CNV deletion 17803354
esv2657128 CNV deletion 23128226
esv2661504 CNV deletion 23128226
esv2669669 CNV deletion 23128226
esv2674106 CNV deletion 23128226
esv26747 CNV gain+loss 19812545
esv2717856 CNV deletion 23290073
esv2717857 CNV deletion 23290073
esv2717858 CNV deletion 23290073
esv2717859 CNV deletion 23290073
esv2717860 CNV deletion 23290073
esv2717863 CNV deletion 23290073
esv2717864 CNV deletion 23290073
esv2717866 CNV deletion 23290073
esv2717867 CNV deletion 23290073
esv32942 CNV gain+loss 17666407
esv3555852 CNV deletion 23714750
esv3643414 CNV gain 21293372
esv3643415 CNV loss 21293372
esv3893156 CNV loss 25118596
esv989730 CNV deletion 20482838
nsv1070627 CNV deletion 25765185
nsv1071888 CNV deletion 25765185
nsv1072838 CNV deletion 25765185
nsv1118800 CNV deletion 24896259
nsv1123207 CNV deletion 24896259
nsv1126503 CNV deletion 24896259
nsv1160561 CNV deletion 26073780
nsv138132 CNV insertion 16902084
nsv470107 CNV loss 18288195
nsv472610 CNV novel sequence insertion 20440878
nsv578363 CNV loss 21841781
nsv578366 CNV loss 21841781
nsv820901 CNV deletion 20802225
nsv828388 CNV gain 20364138
nsv953942 CNV deletion 24416366

Variation tolerance for CSNK1G2 Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK1G2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK1G2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1G2 Gene

Disorders for CSNK1G2 Gene

Relevant External Links for CSNK1G2

Genetic Association Database (GAD)
CSNK1G2
Human Genome Epidemiology (HuGE) Navigator
CSNK1G2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK1G2

No disorders were found for CSNK1G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK1G2 Gene

Publications for CSNK1G2 Gene

  1. Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population. (PMID: 15342122) Yinan M. … Xiru W. (Neurosci. Lett. 2004) 3 4 22 46 64
  2. Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2). (PMID: 9403068) Kitabayashi A.N. … Hashimoto K. (Genomics 1997) 2 3 4 22 64
  3. Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. (PMID: 18794808) Guo X. … Wang X.-F. (Oncogene 2008) 3 4 22 64
  4. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. (PMID: 15077195) Mishra S.K. … Kumar R. (Oncogene 2004) 3 4 22 64
  5. [Five single nucleotide polymorphisms of casein kinase I gamma 2 gene in children with familial febrile convulsions]. (PMID: 15300631) Ma Y.N. … Qi Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004) 3 22 46 64

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Sources for CSNK1G2 Gene

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