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Aliases for CSNK1G1 Gene

Aliases for CSNK1G1 Gene

  • Casein Kinase 1 Gamma 1 2 3 5
  • EC 2.7.11.1 4 61
  • Casein Kinase I Isoform Gamma-1 3
  • Casein Kinase 1, Gamma 1 2
  • CKI-Gamma 1 4
  • CK1gamma1 3
  • EC 2.7.11 61

External Ids for CSNK1G1 Gene

Previous GeneCards Identifiers for CSNK1G1 Gene

  • GC15M060250
  • GC15M057620
  • GC15M062036
  • GC15M062177
  • GC15M062179
  • GC15M062248
  • GC15M064457
  • GC15M041282

Summaries for CSNK1G1 Gene

Entrez Gene Summary for CSNK1G1 Gene

  • This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE). [provided by RefSeq, Jul 2016]

GeneCards Summary for CSNK1G1 Gene

CSNK1G1 (Casein Kinase 1 Gamma 1) is a Protein Coding gene. Diseases associated with CSNK1G1 include Epileptic Encephalopathy, Early Infantile, 15. Among its related pathways are GPCR Pathway and mTOR signaling pathway (KEGG). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G3.

UniProtKB/Swiss-Prot for CSNK1G1 Gene

  • Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.

Tocris Summary for CSNK1G1 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1G1 Gene

Genomics for CSNK1G1 Gene

Regulatory Elements for CSNK1G1 Gene

Enhancers for CSNK1G1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G064246 1.7 FANTOM5 Ensembl ENCODE 10.9 +107.7 107733 4.5 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF609 TRIP4 CSNK1G1 PPIB ENSG00000252774 ENSG00000265967 RNU6-549P SNX22 HERC1 RBPMS2
GH15G064459 1.8 VISTA FANTOM5 ENCODE 5.1 -104.7 -104731 3.7 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D TRIP4 CSNK1G1 PLEKHO2 ZNF609 ENSG00000259682
GH15G064378 0.8 ENCODE 10.8 -22.7 -22716 1.8 BCOR HIC1 GTF3C2 ZNF121 ZFHX2 SCRT2 FOS TCF7L2 SCRT1 CEBPB TRIP4 CSNK1G1 ENSG00000259316
GH15G064150 1.3 ENCODE dbSUPER 6.6 +203.4 203396 3.9 HDGF AGO1 ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 FOS DEK TRIP4 SNX22 CSNK1G1 GC15M064162 GC15M064164
GH15G064354 1.1 ENCODE 6 +0.2 239 2.9 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A ZBTB7B YY1 KLF13 TRIP4 PCLAF CSNK1G1 GC15P068423
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CSNK1G1 on UCSC Golden Path with GeneCards custom track

Promoters for CSNK1G1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000077933 359 1801 HDGF PKNOX1 AGO1 ZFP64 ARID4B SIN3A ZBTB7B YY1 KLF13 ZNF263

Genomic Location for CSNK1G1 Gene

Chromosome:
15
Start:
64,165,517 bp from pter
End:
64,356,259 bp from pter
Size:
190,743 bases
Orientation:
Minus strand

Genomic View for CSNK1G1 Gene

Genes around CSNK1G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1G1 Gene

Proteins for CSNK1G1 Gene

  • Protein details for CSNK1G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCP0-KC1G1_HUMAN
    Recommended name:
    Casein kinase I isoform gamma-1
    Protein Accession:
    Q9HCP0
    Secondary Accessions:
    • Q5JPH1
    • Q96AE9
    • Q9HCP1

    Protein attributes for CSNK1G1 Gene

    Size:
    422 amino acids
    Molecular mass:
    48511 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CSNK1G1 Gene

    Alternative splice isoforms for CSNK1G1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSNK1G1 Gene

Selected DME Specific Peptides for CSNK1G1 Gene

Q9HCP0:
  • SSGVLMVGPNFRVGKKIGCGNFGEL
  • LIYRDVKPENFL
  • LCENFPEEM
  • HCSRPSG
  • TYLRYVRRLDFFEKPDY
  • KSRAPQLHLEYRFYK
  • SNAPITA
  • LKTVLMIAIQL
  • GSVHVDSG
  • YDWVGRPIPTP
  • EQSRRDDLE
  • LTGTARY
  • LPWQGLKA
  • LGKNLYTNEYVAIKLEP
  • SAITRESH
  • GTARYMSINTH
  • QVVSSTNGELN
  • CCCFFKR
  • LLGPSLEDLF
  • IIDFGLA
  • REKDERQRTTK

Post-translational modifications for CSNK1G1 Gene

Domains & Families for CSNK1G1 Gene

Gene Families for CSNK1G1 Gene

Suggested Antigen Peptide Sequences for CSNK1G1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCP0

UniProtKB/Swiss-Prot:

KC1G1_HUMAN :
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1G1: view

Function for CSNK1G1 Gene

Molecular function for CSNK1G1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Repressed by 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine (DB08325).
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.

Enzyme Numbers (IUBMB) for CSNK1G1 Gene

Gene Ontology (GO) - Molecular Function for CSNK1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA,IEA 25500533
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CSNK1G1: view
genes like me logo Genes that share phenotypes with CSNK1G1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CSNK1G1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSNK1G1 Gene

Localization for CSNK1G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1G1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1G1 gene
Compartment Confidence
cytosol 5
nucleus 4

Gene Ontology (GO) - Cellular Components for CSNK1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CSNK1G1: view

Pathways & Interactions for CSNK1G1 Gene

genes like me logo Genes that share pathways with CSNK1G1: view

SIGNOR curated interactions for CSNK1G1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CSNK1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006897 endocytosis IBA --
GO:0008360 regulation of cell shape IBA --
GO:0016055 Wnt signaling pathway IBA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CSNK1G1: view

Drugs & Compounds for CSNK1G1 Gene

(6) Drugs for CSNK1G1 Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE Experimental Pharma Target 0
CKI 7 dihydrochloride Pharma CK1 inhibitor 0
D4476 Pharma CK1/ALK5 inhibitor,specific and cell permeable, Selective CK1 inhibitor. Also inhibits TGF-betaRI 0
LH846 Pharma Casein kinases inhibitor, Selective casein kinase 1delta inhibitor 0
PF 4800567 hydrochloride Pharma Selective casein kinase 1eta inhibitor 0

(5) Tocris Compounds for CSNK1G1 Gene

Compound Action Cas Number
CKI 7 dihydrochloride CK1 inhibitor 1177141-67-1
D 4476 Selective CK1 inhibitor. Also inhibits TGF-betaRI 301836-43-1
LH 846 Selective casein kinase 1delta inhibitor 639052-78-1
PF 4800567 hydrochloride Selective casein kinase 1eta inhibitor 1391052-28-0
PF 670462 Potent and selective CK1eta and CK1delta inhibitor 950912-80-8
genes like me logo Genes that share compounds with CSNK1G1: view

Transcripts for CSNK1G1 Gene

Unigene Clusters for CSNK1G1 Gene

Casein kinase 1, gamma 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: - - - - -
SP8:

ExUns: 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for CSNK1G1 Gene

GeneLoc Exon Structure for
CSNK1G1
ECgene alternative splicing isoforms for
CSNK1G1

Expression for CSNK1G1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSNK1G1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSNK1G1 Gene

This gene is overexpressed in Bone (28.9) and Peripheral blood mononuclear cells (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CSNK1G1 Gene



Protein tissue co-expression partners for CSNK1G1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CSNK1G1 Gene:

CSNK1G1

SOURCE GeneReport for Unigene cluster for CSNK1G1 Gene:

Hs.646508

Evidence on tissue expression from TISSUES for CSNK1G1 Gene

  • Nervous system(4.4)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with CSNK1G1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1G1 Gene

Orthologs for CSNK1G1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSNK1G1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK1G1 34 35
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia CSNK1G1 34
  • 94.79 (n)
-- 35
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CSNK1G1 34 35
  • 93.84 (n)
mouse
(Mus musculus)
Mammalia Csnk1g1 34 16
  • 93.68 (n)
rat
(Rattus norvegicus)
Mammalia Csnk1g1 34
  • 90.49 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 87 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves CSNK1G1 34 35
  • 84.88 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 77 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk1g1 34
  • 79.39 (n)
Str.1580 34
zebrafish
(Danio rerio)
Actinopterygii csnk1g1 34 35
  • 75.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta gish 35 36
  • 55 (a)
OneToMany
CG9962 36
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea Y106G6E.6 36
  • 77 (a)
csnk-1 35
  • 65 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRR25 35
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2609 35
  • 69 (a)
OneToMany
Species where no ortholog for CSNK1G1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK1G1 Gene

ENSEMBL:
Gene Tree for CSNK1G1 (if available)
TreeFam:
Gene Tree for CSNK1G1 (if available)

Paralogs for CSNK1G1 Gene

(6) SIMAP similar genes for CSNK1G1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CSNK1G1: view

Variants for CSNK1G1 Gene

Sequence variations from dbSNP and Humsavar for CSNK1G1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs587777544 Uncertain significance 64,207,586(+) TCTCC(A/G)GCTTT reference, missense
rs1000006440 -- 64,289,440(+) TAACC(G/T)TAACA intron-variant
rs1000058010 -- 64,221,867(+) GTATG(C/G)TGATT intron-variant
rs1000074630 -- 64,306,052(+) TGCCA(C/T)AGGAA intron-variant
rs1000083322 -- 64,277,075(+) ATCAT(C/T)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK1G1 Gene

Variant ID Type Subtype PubMed ID
dgv1223n106 CNV deletion 24896259
esv2396678 CNV deletion 18987734
esv2551673 CNV deletion 19546169
esv2610243 CNV deletion 19546169
esv2749779 CNV deletion 23290073
esv2749780 CNV deletion 23290073
esv2749781 CNV deletion 23290073
esv3552561 CNV deletion 23714750
esv3636730 CNV gain 21293372
esv3636731 CNV loss 21293372
esv3892709 CNV loss 25118596
esv996092 CNV deletion 20482838
nsv1069593 CNV deletion 25765185
nsv1122975 CNV deletion 24896259
nsv1131196 CNV deletion 24896259
nsv1146885 CNV duplication 26484159
nsv472196 CNV novel sequence insertion 20440878
nsv512398 CNV loss 21212237
nsv833036 CNV loss 17160897
nsv94545 CNV deletion 16902084
nsv957993 CNV deletion 24416366

Variation tolerance for CSNK1G1 Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK1G1 Gene

Human Gene Mutation Database (HGMD)
CSNK1G1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK1G1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1G1 Gene

Disorders for CSNK1G1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CSNK1G1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
epileptic encephalopathy, early infantile, 15
  • ohtahara syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CSNK1G1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK1G1
genes like me logo Genes that share disorders with CSNK1G1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSNK1G1 Gene

Publications for CSNK1G1 Gene

  1. Cloning, expression analysis and chromosome mapping of human casein kinase 1 gamma1 (CSNK1G1): identification of two types of cDNA encoding the kinase protein associated with heterologous carboxy- terminal sequences. (PMID: 11124537) Kusuda J. … Hashimoto K. (Cytogenet. Cell Genet. 2000) 2 3 4 22 64
  2. Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. (PMID: 21680713) Meng Z. … Dunphy W.G. (Mol. Biol. Cell 2011) 3 4 64
  3. Cyclin T1-dependent genes in activated CD4 T and macrophage cell lines appear enriched in HIV-1 co-factors. (PMID: 18773076) Yu W. … Rice A.P. (PLoS ONE 2008) 3 22 64
  4. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CSNK1G1 Gene

Sources for CSNK1G1 Gene

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