Aliases for CSNK1G1 Gene
Aliases for CSNK1G1 Gene
External Ids for CSNK1G1 Gene
- HGNC: 2454
- Entrez Gene: 53944
- Ensembl: ENSG00000169118
- OMIM: 606274
- UniProtKB: Q9HCP0
Previous GeneCards Identifiers for CSNK1G1 Gene
- GC15M060250
- GC15M057620
- GC15M062036
- GC15M062177
- GC15M062179
- GC15M062248
- GC15M064457
- GC15M041282
Summaries for CSNK1G1 Gene
-
This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE). [provided by RefSeq, Jul 2016]
GeneCards Summary for CSNK1G1 Gene
CSNK1G1 (Casein Kinase 1 Gamma 1) is a Protein Coding gene. Diseases associated with CSNK1G1 include Epileptic Encephalopathy, Early Infantile, 15. Among its related pathways are GPCR Pathway and mTOR signaling pathway (KEGG). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G3.
UniProtKB/Swiss-Prot for CSNK1G1 Gene
-
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.
-
Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.
No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1G1 Gene
Genomics for CSNK1G1 Gene
Regulatory Elements for CSNK1G1 Gene
Enhancers for CSNK1G1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH15G064246 | 1.7 | FANTOM5 Ensembl ENCODE | 10.9 | +107.7 | 107733 | 4.5 | HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 | ZNF609 TRIP4 CSNK1G1 PPIB ENSG00000252774 ENSG00000265967 RNU6-549P SNX22 HERC1 RBPMS2 |
| GH15G064459 | 1.8 | VISTA FANTOM5 ENCODE | 5.1 | -104.7 | -104731 | 3.7 | CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D | TRIP4 CSNK1G1 PLEKHO2 ZNF609 ENSG00000259682 |
| GH15G064378 | 0.8 | ENCODE | 10.8 | -22.7 | -22716 | 1.8 | BCOR HIC1 GTF3C2 ZNF121 ZFHX2 SCRT2 FOS TCF7L2 SCRT1 CEBPB | TRIP4 CSNK1G1 ENSG00000259316 |
| GH15G064150 | 1.3 | ENCODE dbSUPER | 6.6 | +203.4 | 203396 | 3.9 | HDGF AGO1 ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 FOS DEK | TRIP4 SNX22 CSNK1G1 GC15M064164 GC15M064162 |
| GH15G064354 | 1.1 | ENCODE | 5.9 | +0.2 | 239 | 2.9 | HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A ZBTB7B YY1 KLF13 | TRIP4 PCLAF CSNK1G1 GC15P068423 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CSNK1G1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CSNK1G1 gene promoter:
Regulatory Element Products
Genomic Location for CSNK1G1 Gene
- Chromosome:
- 15
- Start:
- 64,165,517 bp from pter
- End:
- 64,356,259 bp from pter
- Size:
- 190,743 bases
- Orientation:
- Minus strand
Genomic View for CSNK1G1 Gene
Genes around CSNK1G1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q22.31 by Ensembl
- 15q22.31 by Entrez Gene
- 15q22.31 by HGNC
CSNK1G1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CSNK1G1 Gene
Proteins for CSNK1G1 Gene
-
Protein details for CSNK1G1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HCP0-KC1G1_HUMAN
- Recommended name:
- Casein kinase I isoform gamma-1
- Protein Accession:
- Q9HCP0
- Q5JPH1
- Q96AE9
- Q9HCP1
Protein attributes for CSNK1G1 Gene
- Size:
- 422 amino acids
- Molecular mass:
- 48511 Da
- Quaternary structure:
-
- Monomer.
Protein Expression for CSNK1G1 Gene
Selected DME Specific Peptides for CSNK1G1 Gene
- Q9HCP0:
-
- SSGVLMVGPNFRVGKKIGCGNFGEL
- LIYRDVKPENFL
- LCENFPEEM
- HCSRPSG
- TYLRYVRRLDFFEKPDY
- KSRAPQLHLEYRFYK
- SNAPITA
- LKTVLMIAIQL
- GSVHVDSG
- YDWVGRPIPTP
- EQSRRDDLE
- LTGTARY
- LPWQGLKA
- LGKNLYTNEYVAIKLEP
- SAITRESH
- GTARYMSINTH
- QVVSSTNGELN
- CCCFFKR
- LLGPSLEDLF
- IIDFGLA
- REKDERQRTTK
Post-translational modifications for CSNK1G1 Gene
- Autophosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CSNK1G1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CSNK1G1 (Casein Kinase 1 gamma)
- Novus Biologicals Antibodies for CSNK1G1
- Invitrogen Antibodies for CSNK1G1
- antibodies-online Antibodies for CSNK1G1: See all 81
- GeneTex CSNK1G1 antibody for CSNK1G1
Protein Products
- EMD Millipore Purified and/or Recombinant CSNK1G1 Protein
-
OriGene Purified Proteins for CSNK1G1
- Search Origene for MassSpec and Protein Over-expression Lysates for CSNK1G1
- Origene Custom Protein Services for CSNK1G1
- Sino Biological Recombinant Proteins for CSNK1G1
- Sino Biological Cell Lysates for CSNK1G1
- antibodies-online Proteins for CSNK1G1: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CSNK1G1
Assay Products
Domains & Families for CSNK1G1 Gene
Gene Families for CSNK1G1 Gene
- IUPHAR :
Protein Domains for CSNK1G1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CSNK1G1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9HCP0UniProtKB/Swiss-Prot:
KC1G1_HUMAN :- Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Function for CSNK1G1 Gene
Molecular function for CSNK1G1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Repressed by 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine (DB08325).
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.
Enzyme Numbers (IUBMB) for CSNK1G1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IDA,IEA | 25500533 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for CSNK1G1 Gene
- GenomeRNAi human phenotypes for CSNK1G1:
-
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Increased G1 DNA content
- Decreased substrate adherent cell growth
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Upregulation of Wnt pathway
- Increased cell migration
- Increased Nanog expression
- Condensed cis-Golgi
Animal Model Products
-
Taconic Biosciences Mouse Models for CSNK1G1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CSNK1G1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CSNK1G1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1G1 gene
- Search ViGene Biosciences for CSNK1G1
CRISPR Products
-
OriGene CRISPR knockouts for CSNK1G1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSNK1G1
- GenScript: Design CRISPR guide RNA sequences for CSNK1G1
miRNA for CSNK1G1 Gene
- miRTarBase miRNAs that target CSNK1G1
-
- hsa-mir-130b-3p (MIRT020171)
- hsa-mir-93-5p (MIRT028049)
- hsa-mir-30a-5p (MIRT028532)
- hsa-mir-26b-5p (MIRT029209)
- hsa-mir-19b-3p (MIRT031148)
- hsa-mir-222-3p (MIRT046652)
- ebv-mir-bart13-3p (MIRT440865)
- hsa-mir-653-3p (MIRT502687)
- hsa-mir-4420 (MIRT502688)
- hsa-mir-181b-3p (MIRT502689)
- hsa-mir-181b-2-3p (MIRT502690)
- hsa-mir-5196-5p (MIRT502691)
- hsa-mir-4747-5p (MIRT502692)
- hsa-mir-4533 (MIRT502693)
- hsa-mir-5192 (MIRT502694)
- hsa-mir-6837-3p (MIRT502695)
- hsa-mir-3607-3p (MIRT502696)
- hsa-mir-1208 (MIRT502697)
- hsa-mir-6760-3p (MIRT502698)
- hsa-mir-4428 (MIRT502699)
- hsa-mir-30d-5p (MIRT502700)
- hsa-mir-30c-5p (MIRT502701)
- hsa-mir-30e-5p (MIRT502702)
- hsa-mir-30b-5p (MIRT502703)
miRNA Products
- Search ViGene Biosciences for CSNK1G1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CSNK1G1
- Browse OriGene Inhibitory RNA Products For CSNK1G1
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1G1 gene
Clone Products
-
OriGene ORF clones in human for CSNK1G1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CSNK1G1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CSNK1G1
- VectorBuilder custom plasmid, inducible vectors for CSNK1G1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK1G1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CSNK1G1
-
ViGene Biosciences adenoviral particle packaged cDNA for CSNK1G1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CSNK1G1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1G1 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSNK1G1 Gene
Localization for CSNK1G1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CSNK1G1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for CSNK1G1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Hedgehog Pathway |
.40
|
|
| 2 | Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling | ||
| 3 | DARPP-32 Phosphorylation | ||
| 4 | mTOR signaling pathway (KEGG) | ||
| 5 | Dopamine-DARPP32 Feedback onto cAMP Pathway | ||
Pathways by source for CSNK1G1 Gene
5 BioSystems pathways for CSNK1G1 Gene
1 KEGG pathway for CSNK1G1 Gene
1 GeneGo (Thomson Reuters) pathway for CSNK1G1 Gene
4 R&D Systems pathways for CSNK1G1 Gene
1 Tocris pathway for CSNK1G1 Gene
5 Qiagen pathways for CSNK1G1 Gene
Interacting Proteins for CSNK1G1 Gene
Selected Interacting proteins:
ENSP00000305777
Q9HCP0-KC1G1_HUMAN
for CSNK1G1 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006897 | endocytosis | IBA | -- |
| GO:0008360 | regulation of cell shape | IBA | -- |
| GO:0016055 | Wnt signaling pathway | IBA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
Drugs & Compounds for CSNK1G1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE | Experimental | Pharma | Target | 0 | ||
| CKI 7 dihydrochloride | Pharma | CK1 inhibitor | 0 | |||
| D4476 | Pharma | CK1/ALK5 inhibitor,specific and cell permeable, Selective CK1 inhibitor. Also inhibits TGF-betaRI | 0 | |||
| LH846 | Pharma | Casein kinases inhibitor, Selective casein kinase 1delta inhibitor | 0 | |||
| PF 4800567 hydrochloride | Pharma | Selective casein kinase 1eta inhibitor | 0 |
(5) Tocris Compounds for CSNK1G1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CKI 7 dihydrochloride | CK1 inhibitor | 1177141-67-1 |
| D 4476 | Selective CK1 inhibitor. Also inhibits TGF-betaRI | 301836-43-1 |
| LH 846 | Selective casein kinase 1delta inhibitor | 639052-78-1 |
| PF 4800567 hydrochloride | Selective casein kinase 1eta inhibitor | 1391052-28-0 |
| PF 670462 | Potent and selective CK1eta and CK1delta inhibitor | 950912-80-8 |
Transcripts for CSNK1G1 Gene
mRNA/cDNA for CSNK1G1 Gene
- (4) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (712) Selected AceView cDNA sequences:
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CSNK1G1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CSNK1G1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSNK1G1
- GenScript: Design CRISPR guide RNA sequences for CSNK1G1
miRNA Products
- Search ViGene Biosciences for CSNK1G1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CSNK1G1
- Browse OriGene Inhibitory RNA Products For CSNK1G1
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1G1 gene
Clone Products
-
OriGene ORF clones in human for CSNK1G1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CSNK1G1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CSNK1G1
- VectorBuilder custom plasmid, inducible vectors for CSNK1G1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK1G1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 18b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: |
Expression for CSNK1G1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Bone (28.9) and Peripheral blood mononuclear cells (25.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CSNK1G1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CSNK1G1 Gene:
CSNK1G1SOURCE GeneReport for Unigene cluster for CSNK1G1 Gene:
Hs.646508Evidence on tissue expression from TISSUES for CSNK1G1 Gene
- Nervous system(4.4)
- Muscle(4.1)
Primer Products
-
OriGene qPCR primer pairs for CSNK1G1
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1G1 Gene
Orthologs for CSNK1G1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CSNK1G1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CSNK1G1 34 |
|
||
| -- 35 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | CSNK1G1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Csnk1g1 34 16 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Csnk1g1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CSNK1G1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | csnk1g1 34 |
|
||
| Str.1580 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | csnk1g1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | gish 36 35 |
|
||
| CG9962 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | Y106G6E.6 36 |
|
|
|
| csnk-1 35 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HRR25 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2609 35 |
|
OneToMany |
- Species where no ortholog for CSNK1G1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CSNK1G1 Gene
Paralogs for CSNK1G1 Gene
(6) SIMAP similar genes for CSNK1G1 Gene using alignment to 2 proteins:
Variants for CSNK1G1 Gene
| SNP ID | Clin | Chr 15 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs587777544 | Uncertain significance | 64,207,586(+) | TCTCC(A/G)GCTTT | reference, missense | |
| rs1000006440 | -- | 64,289,440(+) | TAACC(G/T)TAACA | intron-variant | |
| rs1000058010 | -- | 64,221,867(+) | GTATG(C/G)TGATT | intron-variant | |
| rs1000074630 | -- | 64,306,052(+) | TGCCA(C/T)AGGAA | intron-variant | |
| rs1000083322 | -- | 64,277,075(+) | ATCAT(C/T)AGACA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1223n106 | CNV | deletion | 24896259 |
| esv2396678 | CNV | deletion | 18987734 |
| esv2551673 | CNV | deletion | 19546169 |
| esv2610243 | CNV | deletion | 19546169 |
| esv2749779 | CNV | deletion | 23290073 |
| esv2749780 | CNV | deletion | 23290073 |
| esv2749781 | CNV | deletion | 23290073 |
| esv3552561 | CNV | deletion | 23714750 |
| esv3636730 | CNV | gain | 21293372 |
| esv3636731 | CNV | loss | 21293372 |
| esv3892709 | CNV | loss | 25118596 |
| esv996092 | CNV | deletion | 20482838 |
| nsv1069593 | CNV | deletion | 25765185 |
| nsv1122975 | CNV | deletion | 24896259 |
| nsv1131196 | CNV | deletion | 24896259 |
| nsv1146885 | CNV | duplication | 26484159 |
| nsv472196 | CNV | novel sequence insertion | 20440878 |
| nsv512398 | CNV | loss | 21212237 |
| nsv833036 | CNV | loss | 17160897 |
| nsv94545 | CNV | deletion | 16902084 |
| nsv957993 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.46;
54.90% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CSNK1G1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1G1 Gene
Disorders for CSNK1G1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| epileptic encephalopathy, early infantile, 15 |
|
|
Search CSNK1G1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CSNK1G1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CSNK1G1
No data available for UniProtKB/Swiss-Prot and Genatlas for CSNK1G1 Gene
Publications for CSNK1G1 Gene
- Cloning, expression analysis and chromosome mapping of human casein kinase 1 gamma1 (CSNK1G1): identification of two types of cDNA encoding the kinase protein associated with heterologous carboxy- terminal sequences. (PMID: 11124537) Kusuda J. … Hashimoto K. (Cytogenet. Cell Genet. 2000) 2 3 4 22 64
- Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. (PMID: 21680713) Meng Z. … Dunphy W.G. (Mol. Biol. Cell 2011) 3 4 64
- Cyclin T1-dependent genes in activated CD4 T and macrophage cell lines appear enriched in HIV-1 co-factors. (PMID: 18773076) Yu W. … Rice A.P. (PLoS ONE 2008) 3 22 64
- An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for CSNK1G1 Gene
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Sources for CSNK1G1 Gene
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