Aliases for CSNK1G1 Gene
External Ids for CSNK1G1 Gene
Previous GeneCards Identifiers for CSNK1G1 Gene
This gene encodes a member of the casein kinase I gene family. The encoded protein is a serine/threonine kinase that phosphorylates acidic proteins, and participates in pathways for cell growth. [provided by RefSeq, Nov 2011]
GeneCards Summary for CSNK1G1 Gene
CSNK1G1 (Casein Kinase 1, Gamma 1) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein serine/threonine kinase activity and glycoprotein binding. An important paralog of this gene is CSNK1G2.
UniProtKB/Swiss-Prot for CSNK1G1 Gene
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.
Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in a number of cellular processes including DNA repair, cell division, nuclear localization and membrane transport. CK1 isoforms also have key roles in the developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor, CK1alpha is thought to phosphorylate beta-catenin as part of its degradation process. Upon binding of Wnt to its receptor (Frizzled) CK1epsilon phosphorylates the intracellular signaling protein, Dishevelled and CK1gamma directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1alpha plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound state, and then when Hh binds to Patched, CK1alpha phosphorylates the 7-TM co-receptor, Smoothened.