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Aliases for CSNK1G1 Gene

Aliases for CSNK1G1 Gene

  • Casein Kinase 1, Gamma 1 2 3
  • CKI-Gamma 1 3 4
  • EC 2.7.11.1 4 63
  • Casein Kinase I Isoform Gamma-1 3
  • CK1gamma1 3
  • EC 2.7.11 63

External Ids for CSNK1G1 Gene

Previous GeneCards Identifiers for CSNK1G1 Gene

  • GC15M060250
  • GC15M057620
  • GC15M062036
  • GC15M062177
  • GC15M062179
  • GC15M062248
  • GC15M064457
  • GC15M041282

Summaries for CSNK1G1 Gene

Entrez Gene Summary for CSNK1G1 Gene

  • This gene encodes a member of the casein kinase I gene family. The encoded protein is a serine/threonine kinase that phosphorylates acidic proteins, and participates in pathways for cell growth. [provided by RefSeq, Nov 2011]

GeneCards Summary for CSNK1G1 Gene

CSNK1G1 (Casein Kinase 1, Gamma 1) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein serine/threonine kinase activity and glycoprotein binding. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for CSNK1G1 Gene

  • Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.

Tocris Summary for CSNK1G1 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in a number of cellular processes including DNA repair, cell division, nuclear localization and membrane transport. CK1 isoforms also have key roles in the developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor, CK1alpha is thought to phosphorylate beta-catenin as part of its degradation process. Upon binding of Wnt to its receptor (Frizzled) CK1epsilon phosphorylates the intracellular signaling protein, Dishevelled and CK1gamma directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1alpha plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound state, and then when Hh binds to Patched, CK1alpha phosphorylates the 7-TM co-receptor, Smoothened.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1G1 Gene

Genomics for CSNK1G1 Gene

Regulatory Elements for CSNK1G1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CSNK1G1 Gene

Start:
64,165,517 bp from pter
End:
64,356,243 bp from pter
Size:
190,727 bases
Orientation:
Minus strand

Genomic View for CSNK1G1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSNK1G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1G1 Gene

Proteins for CSNK1G1 Gene

  • Protein details for CSNK1G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCP0-KC1G1_HUMAN
    Recommended name:
    Casein kinase I isoform gamma-1
    Protein Accession:
    Q9HCP0
    Secondary Accessions:
    • Q5JPH1
    • Q96AE9
    • Q9HCP1

    Protein attributes for CSNK1G1 Gene

    Size:
    422 amino acids
    Molecular mass:
    48511 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CSNK1G1 Gene

    Alternative splice isoforms for CSNK1G1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSNK1G1 Gene

Proteomics data for CSNK1G1 Gene at MOPED

Post-translational modifications for CSNK1G1 Gene

Other Protein References for CSNK1G1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CSNK1G1 (Casein Kinase 1 gamma)

Domains for CSNK1G1 Gene

Gene Families for CSNK1G1 Gene

Suggested Antigen Peptide Sequences for CSNK1G1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCP0

UniProtKB/Swiss-Prot:

KC1G1_HUMAN :
  • Q9HCP0
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1G1: view

Function for CSNK1G1 Gene

Molecular function for CSNK1G1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Repressed by 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine (DB08325)
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.

Enzyme Numbers (IUBMB) for CSNK1G1 Gene

Gene Ontology (GO) - Molecular Function for CSNK1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CSNK1G1: view
genes like me logo Genes that share phenotypes with CSNK1G1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSNK1G1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CSNK1G1 Gene

Localization for CSNK1G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1G1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK1G1 Gene COMPARTMENTS Subcellular localization image for CSNK1G1 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for CSNK1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CSNK1G1: view

Pathways for CSNK1G1 Gene

genes like me logo Genes that share pathways with CSNK1G1: view

Pathways by source for CSNK1G1 Gene

1 GeneGo (Thomson Reuters) pathway for CSNK1G1 Gene
1 R&D Systems pathway for CSNK1G1 Gene
1 Tocris pathway for CSNK1G1 Gene

Gene Ontology (GO) - Biological Process for CSNK1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0006897 endocytosis IBA --
GO:0008360 regulation of cell shape IBA --
GO:0016055 Wnt signaling pathway IBA --
GO:0018105 peptidyl-serine phosphorylation IBA --
genes like me logo Genes that share ontologies with CSNK1G1: view

Compounds for CSNK1G1 Gene

(5) Tocris Compounds for CSNK1G1 Gene

Compound Action Cas Number
D 4476 Selective CK1 inhibitor. Also inhibits TGF-betaRI [301836-43-1]
LH 846 Selective casein kinase 1delta inhibitor [639052-78-1]
PF 4800567 hydrochloride Selective casein kinase 1eta inhibitor [1391052-28-0]
PF 670462 Potent and selective CK1eta and CK1delta inhibitor [950912-80-8]
TA 02 Induces cardiomyocyte differentiation from hESCs

(1) Drugbank Compounds for CSNK1G1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE
target
genes like me logo Genes that share compounds with CSNK1G1: view

Transcripts for CSNK1G1 Gene

mRNA/cDNA for CSNK1G1 Gene

Unigene Clusters for CSNK1G1 Gene

Casein kinase 1, gamma 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSNK1G1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CSNK1G1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: - - - - -
SP8:

ExUns: 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for CSNK1G1 Gene

GeneLoc Exon Structure for
CSNK1G1
ECgene alternative splicing isoforms for
CSNK1G1

Expression for CSNK1G1 Gene

mRNA expression in normal human tissues for CSNK1G1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CSNK1G1 Gene

SOURCE GeneReport for Unigene cluster for CSNK1G1 Gene Hs.646508

genes like me logo Genes that share expressions with CSNK1G1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSNK1G1 Gene

Orthologs for CSNK1G1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSNK1G1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK1G1 35
  • 99.76 (n)
  • 100 (a)
CSNK1G1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSNK1G1 35
  • 93.84 (n)
  • 98.1 (a)
CSNK1G1 36
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 91 (a)
OneToMany
CSNK1G1 35
  • 94.79 (n)
  • 99.29 (a)
mouse
(Mus musculus)
Mammalia Csnk1g1 35
  • 93.68 (n)
  • 97.63 (a)
Csnk1g1 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Csnk1g1 35
  • 90.49 (n)
  • 93.83 (a)
chicken
(Gallus gallus)
Aves CSNK1G1 35
  • 84.88 (n)
  • 94.3 (a)
CSNK1G1 36
  • 88 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk1g1 35
  • 79.39 (n)
  • 92.73 (a)
Str.1580 35
zebrafish
(Danio rerio)
Actinopterygii csnk1g1 35
  • 75.63 (n)
  • 89.76 (a)
csnk1g1 36
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta gish 36
  • 55 (a)
OneToMany
gish 37
  • 80 (a)
CG9962 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea csnk-1 36
  • 65 (a)
OneToMany
Y106G6E.6 37
  • 77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRR25 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2609 36
  • 69 (a)
OneToMany
Species with no ortholog for CSNK1G1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK1G1 Gene

ENSEMBL:
Gene Tree for CSNK1G1 (if available)
TreeFam:
Gene Tree for CSNK1G1 (if available)

Paralogs for CSNK1G1 Gene

Selected SIMAP similar genes for CSNK1G1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CSNK1G1: view

Variants for CSNK1G1 Gene

Sequence variations from dbSNP and Humsavar for CSNK1G1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs4008 -- 64,268,523(+) ttgca(C/T)gttct intron-variant
rs976335 -- 64,297,606(+) AGTAG(A/G)AGGAT intron-variant
rs1018301 -- 64,305,069(+) TTTTT(A/T)AAATT intron-variant
rs1106912 -- 64,247,996(-) AGTGA(A/T)TTATA intron-variant
rs1117087 -- 64,306,624(+) ACATT(G/T)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK1G1 Gene

Variant ID Type Subtype PubMed ID
nsv833036 CNV Loss 17160897
esv2749779 CNV Deletion 23290073
nsv904306 CNV Loss 21882294
esv2749780 CNV Deletion 23290073
esv2551673 CNV Deletion 19546169
nsv512398 CNV Loss 21212237
esv2610243 CNV Deletion 19546169
esv996092 CNV Deletion 20482838
esv2396678 CNV Deletion 18987734
esv2749781 CNV Deletion 23290073
nsv94545 CNV Loss 16902084

Relevant External Links for CSNK1G1 Gene

HapMap Linkage Disequilibrium report
CSNK1G1
Human Gene Mutation Database (HGMD)
CSNK1G1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1G1 Gene

Disorders for CSNK1G1 Gene

No disorders were found for CSNK1G1 Gene.

No data available for UniProtKB/Swiss-Prot for CSNK1G1 Gene

Publications for CSNK1G1 Gene

  1. Cloning, expression analysis and chromosome mapping of human casein kinase 1 gamma1 (CSNK1G1): identification of two types of cDNA encoding the kinase protein associated with heterologous carboxy- terminal sequences. (PMID: 11124537) Kusuda J. … Hashimoto K. (Cytogenet. Cell Genet. 2000) 2 3 4 23
  2. Cyclin T1-dependent genes in activated CD4 T and macrophage cell lines appear enriched in HIV-1 co-factors. (PMID: 18773076) Yu W. … Rice A.P. (PLoS ONE 2008) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. (PMID: 21680713) Meng Z. … Dunphy W.G. (Mol. Biol. Cell 2011) 3 4
  5. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4

Products for CSNK1G1 Gene

Sources for CSNK1G1 Gene

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