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CSNK1G1 Gene

protein-coding   GIFtS: 63
GCID: GC15M064457

Casein Kinase 1, Gamma 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Casein Kinase 1, Gamma 11 2
CKI-Gamma 12 3
EC 2.7.11.13 8
CK1gamma12
Casein Kinase I Isoform Gamma-12
EC 2.7.118

External Ids:    HGNC: 24541   Entrez Gene: 539442   Ensembl: ENSG000001691187   OMIM: 6062745   UniProtKB: Q9HCP03   

Export aliases for CSNK1G1 gene to outside databases

Previous GC identifers: GC15M060250 GC15M057620 GC15M062036 GC15M062177 GC15M062179 GC15M062248 GC15M041282


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSNK1G1 Gene:
This gene encodes a member of the casein kinase I gene family. The encoded protein is a serine/threonine kinase
that phosphorylates acidic proteins, and participates in pathways for cell growth. (provided by RefSeq, Nov 2011)

GeneCards Summary for CSNK1G1 Gene:
CSNK1G1 (casein kinase 1, gamma 1) is a protein-coding gene. Diseases associated with CSNK1G1 include tonsillitis, and hiv-1. GO annotations related to this gene include protein serine/threonine kinase activity and glycoprotein binding. An important paralog of this gene is VRK3.

UniProtKB/Swiss-Prot: KC1G1_HUMAN, Q9HCP0
Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential
utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins.
Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
Phosphorylates CLSPN

summary for CSNK1G1 Gene:
Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1,
gamma2, gamma3, delta and epsilon. CK1 is involved in a number of cellular processes including DNA repair,
cell division, nuclear localization and membrane transport. CK1 isoforms also have key roles in the
developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor,
CK1alpha is thought to phosphorylate beta-catenin as part of its degradation process. Upon binding of Wnt to
its receptor (Frizzled) CK1epsilon phosphorylates the intracellular signaling protein, Dishevelled and
CK1gamma directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction
to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1alpha
plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound
state, and then when Hh binds to Patched, CK1alpha phosphorylates the 7-TM co-receptor, Smoothened.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSNK1G1 gene promoter:
         Sox5   Pbx1a   MIF-1   Tal-1beta   Nkx5-1   C/EBPalpha   E47   STAT3   LyF-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSNK1G1 promoter sequence
   Search Chromatin IP Primers for CSNK1G1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSNK1G1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.1-q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.1-q22.31

CSNK1G1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK1G1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M064457:  view genomic region     (about GC identifiers)

Start:
64,457,716 bp from pter      End:
64,648,442 bp from pter
Size:
190,727 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KC1G1_HUMAN, Q9HCP0 (See protein sequence)
Recommended Name: Casein kinase I isoform gamma-1  
Size: 422 amino acids; 48511 Da
Subunit: Monomer (By similarity)
1 PDB 3D structure from and Proteopedia for CSNK1G1:
2CMW (3D)    
Secondary accessions: Q5JPH1 Q96AE9 Q9HCP1
Alternative splicing: 2 isoforms:  Q9HCP0-1   Q9HCP0-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CSNK1G1: NX_Q9HCP0

Explore proteomics data for CSNK1G1 at MOPED

Post-translational modifications: 

  • Autophosphorylated (By similarity)1
  • Ubiquitination2 at Lys255
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CSNK1G1 (Q9HCP0) (see all 21)
     CCCFFKR  HCSRPSG  IIDFGLA  SNAPITA 


    See CSNK1G1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071331.2  
    ENSEMBL proteins: 
     ENSP00000305777   ENSP00000475724   ENSP00000475325   ENSP00000307753  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: casein kinase 1, gamma 1
    Casein kinase 1 (CK1) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR022247 Casein_kinase-1_gamma_C

    Graphical View of Domain Structure for InterPro Entry Q9HCP0

    ProtoNet protein and cluster: Q9HCP0

    UniProtKB/Swiss-Prot: KC1G1_HUMAN, Q9HCP0
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I
    subfamily
    Similarity: Contains 1 protein kinase domain


    CSNK1G1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KC1G1_HUMAN, Q9HCP0
    Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential
    utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins.
    Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
    Phosphorylates CLSPN
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Repressed by 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine (DB08325)

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ----
    GO:0001948glycoprotein binding ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    CSNK1G1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CSNK1G1:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased G1 DNA content  Synthetic lethal with Ras 

    Animal Models:
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    Selected qRT-PCR Assays for microRNAs that regulate CSNK1G1 (see all 188):
    hsa-miR-579 hsa-miR-1321 hsa-miR-106a hsa-miR-519a hsa-miR-208b hsa-miR-149 hsa-miR-637 hsa-miR-3649
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KC1G1_HUMAN, Q9HCP0: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    CSNK1G1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSNK1G1 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    2Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    3GPCR Pathway
    NFAT in Immune Response0.58
    4Translation Insulin regulation of translation
    Translation Regulation activity of EIF20.47
    5Basal cell carcinoma
    Hedgehog signaling pathway0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CSNK1G1
        Wnt Signaling Pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CSNK1G1
        GSK3 Signaling
    Signaling in Gap Junctions
    WNT Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway
    NFAT in Immune Response

    1 Tocris Bioscience Pathway for CSNK1G1
        Hedgehog Pathway

    1 GeneGo (Thomson Reuters) Pathway for CSNK1G1
        Translation Regulation of EIF2 activity

    4 BioSystems Pathways for CSNK1G1
        Canonical Wnt signaling pathway
    FoxO family signaling
    p53 pathway
    Hedgehog signaling events mediated by Gli proteins

    2 Sino Biological Pathways for CSNK1G1
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway


    1 Kegg Pathway  (Kegg details for CSNK1G1):
        Hedgehog signaling pathway


    CSNK1G1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSNK1G1
    Interactions:

        Search GeneGlobe Interaction Network for CSNK1G1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSNK1G1 (Q9HCP02, 3 ENSP000003057774) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUNDC3BQ96NL02, 3, ENSP000003377324MINT-8252901 I2D: score=2 STRING: ENSP00000337732
    C2orf44Q9H6R72, 3MINT-8252857 I2D: score=2 
    FAM219AQ8IW502, 3, ENSP000002976204MINT-8252868 I2D: score=2 STRING: ENSP00000297620
    IKZF1Q134222, 3, ENSP000003316144MINT-8252879 I2D: score=2 STRING: ENSP00000331614
    MKRN1Q9UHC72, 3, ENSP000002559774MINT-8252890 I2D: score=2 STRING: ENSP00000255977
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0016055Wnt signaling pathway IEA--
    GO:0046777protein autophosphorylation ----

    CSNK1G1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Compounds for CSNK1G1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PF 4800567 hydrochlorideSelective casein kinase 1epsilon inhibitor[1188296-52-7]
    D 4476Selective CK1 inhibitor. Also inhibits TGF-betaRI[301836-43-1]
    (R)-DRF053 dihydrochlorideDual CK1/cdk inhibitor[1056016-06-8]
    TAK 715Potent p38 MAPK inhibitor; anti-inflammatory[303162-79-0]
    PF 670462Potent and selective CK1epsilon and CK1delta inhibitor[950912-80-8]

    1 DrugBank Compound for CSNK1G1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CSNK1G1 gene: 
    NM_022048.3  

    Unigene Cluster for CSNK1G1:

    Casein kinase 1, gamma 1
    Hs.646508  [show with all ESTs]
    Unigene Representative Sequence: NM_022048
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303052(uc002ane.3 uc002anf.3 uc002ang.1 uc002anh.1)
    ENST00000607537 ENST00000606225 ENST00000303032(uc002anj.3)
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    hsa-miR-579 hsa-miR-1321 hsa-miR-106a hsa-miR-519a hsa-miR-208b hsa-miR-149 hsa-miR-637 hsa-miR-3649
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    Additional mRNA sequence: 

    AB042563.1 AF223357.2 AK023779.1 AK025179.1 AK026957.1 AK126968.1 AK225960.1 AL137522.1 
    AL832551.1 BC017236.2 BC062995.1 BC077731.1 BC130613.1 BC136504.1 

    14 DOTS entries:

    DT.100030717  DT.40295750  DT.40129260  DT.412193  DT.121022711  DT.100693930  DT.91742815  DT.95157509 
    DT.91742816  DT.404122  DT.91949999  DT.97859923  DT.100852729  DT.121022679 

    Selected AceView cDNA sequences (see all 712):

    BQ424836 AI538747 BU753565 CB112446 AL526554 AI335256 AA366593 BM791587 
    AL832551 BM844404 BQ021334 BI258952 AY598324 BF510627 BM462589 H89485 
    BM758573 BG498644 AA279813 BQ010200 AI016853 CR599494 CD364397 CK903174 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
    SP1:                                                  -                             -                                                     -           -         
    SP2:                    -     -                                                                                               -     -                           
    SP3:                                                  -                             -                                         -     -     -           -         
    SP4:              -     -     -                       -                                                                                                         
    SP5:                          -                       -                                                                                                         

    ExUns: 18b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CSNK1G1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CSNK1G1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAACACAA
    CSNK1G1 Expression
    About this image


    CSNK1G1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Medulla Oblongata
     
     Thyroid (Endocrine System)
    CSNK1G1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSNK1G1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.646508
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CSNK1G1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csnk1g11 , 5 casein kinase 1, gamma 11, 5 93.68(n)1
    97.63(a)1
      9 (35.60 cM)5
    2148971  NM_173185.21  NP_775277.21 
     659089745 
    chicken
    (Gallus gallus)
    Aves CSNK1G11 casein kinase 1, gamma 1 84.88(n)
    94.3(a)
      415328  NM_001005800.1  NP_001005800.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    77(a)
    1 → many
    GL343490.1(429457-446293)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.15802 Transcribed sequence with strong similarity to protein more 81.89(n)    BX749209.1 
    zebrafish
    (Danio rerio)
    Actinopterygii csnk1g11 casein kinase 1, gamma 1 75.63(n)
    89.76(a)
      494092  NM_001008635.1  NP_001008635.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gish3 glia cell migration casein kinase I 80(a)
    (best of 2)
      89B17   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y106G6E.63 casein kinase like 77(a)   I(10236146-10237779)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRR256
    Protein kinase involved in regulating diverse even...
    35(a)
    1 → many
    XVI(164276-165760) YPL204W


    ENSEMBL Gene Tree for CSNK1G1 (if available)
    TreeFam Gene Tree for CSNK1G1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSNK1G1 gene
    VRK32  VRK12  CSNK1G32  VRK22  CSNK1D2  ENSG000002593162  CSNK1A12  CSNK1G22  
    CSNK1A1L2  TTBK12  CSNK1E2  TTBK22  
    6 SIMAP similar genes for CSNK1G1 using alignment to 2 protein entries:     KC1G1_HUMAN (see all proteins):
    CSNK1G2    CSNK1G3    CSNK1E    CSNK1D    CSNK1A1    CSNK1A1L

    CSNK1G1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSNK1G1 (see all 3320)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs793089371,2
    C--44646798(+) AAAAT-/CTGTTTT 1 -- int10--------
    rs1900510911,2
    --64457386(+) GGAATA/GTTTAT 1 -- ds50010--------
    rs1503972611,2
    --64457455(+) GCTCAC/TTGCAA 1 -- ds50010--------
    rs1382288091,2
    --64457504(+) CCTCCC/TGAGTA 1 -- ds50010--------
    rs283806071,2
    C--64457511(+) AGTAGT/CTGGGA 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1460926091,2
    --64457537(+) ACCACC/GCCCAA 1 -- ds50010--------
    rs1811673511,2
    --64457671(+) CACTGC/TGCCTG 1 -- ds50010--------
    rs620242511,2
    C,F--64457917(+) ACCAAC/ACAAAC 1 -- ut315Minor allele frequency- A:0.36WA NA CSA 126
    rs1379778591,2
    --64458156(+) CAAATA/CTCTCT 1 -- ut310--------
    rs11860921,2
    C,H--64458280(+) TACATC/TTAAAA 1 -- ut319Minor allele frequency- T:0.00EA NA MN NS 656

    HapMap Linkage Disequilibrium report for CSNK1G1 (64457716 - 64648442 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CSNK1G1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2551673CNV Deletion19546169
    esv996092CNV Deletion20482838
    esv2749780CNV Deletion23290073
    esv2749779CNV Deletion23290073
    esv2749781CNV Deletion23290073
    esv2396678CNV Deletion18987734
    esv2610243CNV Deletion19546169
    nsv904306CNV Loss21882294
    nsv512398CNV Loss21212237
    nsv94545CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSNK1G1
    DNA2.0 Custom Variant and Variant Library Synthesis for CSNK1G1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606274    OMIM disorders: --

    4 diseases for CSNK1G1:    
    About MalaCards
    tonsillitis    hiv-1    thyroiditis    cerebritis


    CSNK1G1 for disorders           About GeneDecksing


    Export disorders for CSNK1G1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSNK1G1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CSNK1G1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression analysis and chromosome mapping of human casein kinase 1 gamma1 (CSNK1G1): identification of two types of cDNA encoding the kinase protein associated with heterologous carboxy- terminal sequences. (PubMed id 11124537)1, 2, 3, 9 Kusuda J.... Hashimoto K. (Cytogenet. Cell Genet. 2000)
    2. Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. (PubMed id 21680713)1, 2 Meng Z.... Dunphy W.G. (Mol. Biol. Cell 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    5. Cyclin T1-dependent genes in activated CD4 T and macrophage cell lines appear enriched in HIV-1 co-factors. (PubMed id 18773076)1, 9 Yu W....Rice A.P. (PLoS ONE 2008)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 53944 HGNC: 2454 AceView: KIAA0101andCSNK1G1 Ensembl:ENSG00000169118 euGenes: HUgn53944
    ECgene: CSNK1G1 Kegg: 53944 H-InvDB: CSNK1G1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CSNK1G1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSNK1G1 gene:
    Search GeneIP for patents involving CSNK1G1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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