Aliases for CSNK1E Gene
Aliases for CSNK1E Gene
External Ids for CSNK1E Gene
- HGNC: 2453
- Entrez Gene: 1454
- Ensembl: ENSG00000213923
- OMIM: 600863
- UniProtKB: P49674
Previous GeneCards Identifiers for CSNK1E Gene
- GC22M035302
- GC22M036929
- GC22M036930
- GC22M037011
- GC22M038686
- GC22M021653
- GC22M038397
- GC22M038521
- GC22M038831
- GC22M039969
- GC22M040661
Summaries for CSNK1E Gene
-
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
GeneCards Summary for CSNK1E Gene
CSNK1E (Casein Kinase 1 Epsilon) is a Protein Coding gene. Diseases associated with CSNK1E include Advanced Sleep Phase Syndrome. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Circadian rythm related genes. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is LOC400927-CSNK1E.
UniProtKB/Swiss-Prot for CSNK1E Gene
-
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1E Gene
Genomics for CSNK1E Gene
Regulatory Elements for CSNK1E Gene
Enhancers for CSNK1E Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CSNK1E on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CSNK1E gene promoter:
Regulatory Element Products
Genomic Location for CSNK1E Gene
- Chromosome:
- 22
- Start:
- 38,290,691 bp from pter
- End:
- 38,318,084 bp from pter
- Size:
- 27,394 bases
- Orientation:
- Minus strand
Genomic View for CSNK1E Gene
Genes around CSNK1E on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.1 by Ensembl
- 22q13.1 by Entrez Gene
- 22q13.1 by HGNC
CSNK1E Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CSNK1E Gene
Proteins for CSNK1E Gene
-
Protein details for CSNK1E Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49674-KC1E_HUMAN
- Recommended name:
- Casein kinase I isoform epsilon
- Protein Accession:
- P49674
Protein attributes for CSNK1E Gene
- Size:
- 416 amino acids
- Molecular mass:
- 47315 Da
- Quaternary structure:
-
- Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts with ANKRD6, DBNDD2, LRP5, LRP6 and SOCS3. Interacts with SNAI1 (via zinc fingers).
- Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts with ANKRD6, DBNDD2, LRP5, LRP6 and SOCS3. Interacts with SNAI1 (via zinc fingers).
Protein Expression for CSNK1E Gene
Selected DME Specific Peptides for CSNK1E Gene
- P49674:
-
- GEEVAIK
- QGGVGIP
- LGKKGNL
- TKRQKYE
- RERKVSMRLHRGAP
- ESLGYVL
- RSLRFDDKPDY
- RKIGSGSFG
- LFRNLFHR
- SSSDLTGRQ
- EQSRRDDLE
- DLESLGY
- LTGTARY
- LPWQGLKA
- QKYERISEKK
- IHRDVKPDN
- TKHPQLHIESK
- PDNFLMG
- LADQMISRI
- TPIEVLC
- LKTVLLLADQ
- YLRQLFR
- LLGPSLEDLF
- DFGLAKKYRD
- IIDFGLA
- RKFSLKT
- GIEQSRRDD
Post-translational modifications for CSNK1E Gene
- Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.
- Ubiquitination at Lys294
- Modification sites at PhosphoSitePlus
Other Protein References for CSNK1E Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CSNK1E (Casein Kinase 1 epsilon)
- Cell Signaling Technology (CST) Antibodies for CSNK1E (CK1E)
-
Custom Antibody ServicesOriGene Antibodies for CSNK1E
- Novus Biologicals Antibodies for CSNK1E
- Invitrogen Antibodies for CSNK1E
- antibodies-online Antibodies for CSNK1E: See all 120
- GeneTex CSNK1E antibody for CSNK1E
-
Santa Cruz Biotechnology (SCBT) Antibodies for CSNK1E
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CSNK1E
- Origene Custom Protein Services for CSNK1E
- antibodies-online Proteins for CSNK1E: See all 13
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CSNK1E
Assay Products
- antibodies-online Kits for CSNK1E: See all 3
Domains & Families for CSNK1E Gene
Gene Families for CSNK1E Gene
- IUPHAR :
Protein Domains for CSNK1E Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CSNK1E Gene
Graphical View of Domain Structure for InterPro Entry
P49674UniProtKB/Swiss-Prot:
KC1E_HUMAN :- Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Function for CSNK1E Gene
Molecular function for CSNK1E Gene
- GENATLAS Biochemistry:
- casein kinase 1,catalytic unit,epsilon 1,involved in the transduction of WNT signal
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Phosphorylation leads to a decrease of the catalytic activity.
- UniProtKB/Swiss-Prot Function:
- Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated during granulocytic differentiation.
Enzyme Numbers (IUBMB) for CSNK1E Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003723 | RNA binding | IDA | 22681889 |
| GO:0004672 | protein kinase activity | ISS,IDA | -- |
| GO:0004674 | protein serine/threonine kinase activity | TAS | 7797465 |
| GO:0005515 | protein binding | IPI | 11425858 |
Phenotypes for CSNK1E Gene
- MGI mutant phenotypes for CSNK1E:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CSNK1E:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Increased shRNA abundance (Z-score > 2)
- Decreased substrate adherent cell growth
- Decreased IL-8 secretion
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Decreased shRNA abundance (Z-score < -2)
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased circadian period length
- Increased mitotic index
- Increased cell migration
- Decreased viability
- Condensed cis-Golgi
- Decreased IL-13 protein expression
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- Synthetic lethal with gemcitabine
- Reduced beta-catenin activity and colon cancer cell proliferation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CSNK1E
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CSNK1E gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1E gene
- Search ViGene Biosciences for CSNK1E
CRISPR Products
-
OriGene CRISPR knockouts for CSNK1E
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSNK1E
- GenScript: Design CRISPR guide RNA sequences for CSNK1E
miRNA for CSNK1E Gene
- miRTarBase miRNAs that target CSNK1E
-
- hsa-mir-149-5p (MIRT045612)
- hsa-mir-30c-5p (MIRT047921)
- hsa-mir-4268 (MIRT158075)
- hsa-mir-6748-5p (MIRT158115)
- hsa-mir-6756-5p (MIRT158117)
- hsa-mir-6766-5p (MIRT158120)
- hsa-mir-1976 (MIRT352739)
- hsa-mir-3653-5p (MIRT352741)
- hsa-mir-210-3p (MIRT440866)
- hsa-mir-6772-3p (MIRT453733)
- hsa-mir-6880-5p (MIRT453734)
- hsa-mir-3907 (MIRT453735)
- hsa-mir-4483 (MIRT453736)
- hsa-mir-1293 (MIRT453737)
- hsa-mir-6745 (MIRT453738)
- hsa-mir-363-5p (MIRT453739)
- hsa-mir-5192 (MIRT453740)
- hsa-mir-4644 (MIRT453741)
- hsa-mir-4306 (MIRT453742)
- hsa-mir-185-5p (MIRT453743)
- hsa-mir-4448 (MIRT453744)
- hsa-mir-4530 (MIRT453745)
- hsa-mir-194-3p (MIRT453746)
- hsa-mir-4519 (MIRT453747)
- hsa-mir-6838-5p (MIRT453748)
- hsa-mir-497-5p (MIRT453749)
- hsa-mir-424-5p (MIRT453750)
- hsa-mir-195-5p (MIRT453751)
- hsa-mir-16-5p (MIRT453752)
- hsa-mir-15b-5p (MIRT453753)
- hsa-mir-15a-5p (MIRT453754)
- hsa-mir-634 (MIRT453755)
- hsa-mir-5096 (MIRT515259)
- hsa-mir-6839-3p (MIRT515260)
- hsa-mir-3187-3p (MIRT515261)
- hsa-mir-4435 (MIRT515262)
- hsa-mir-588 (MIRT515263)
- hsa-mir-4701-5p (MIRT515264)
- hsa-mir-548s (MIRT515265)
- hsa-mir-197-3p (MIRT515266)
- hsa-mir-629-5p (MIRT515267)
- hsa-mir-411-5p (MIRT515268)
- hsa-mir-4755-3p (MIRT515269)
- hsa-mir-4716-5p (MIRT515270)
- hsa-mir-4781-3p (MIRT515271)
- hsa-mir-5680 (MIRT515272)
- hsa-mir-4506 (MIRT515273)
- hsa-mir-498 (MIRT676617)
- hsa-mir-5089-5p (MIRT676618)
- hsa-mir-4279 (MIRT676619)
- hsa-mir-23b-5p (MIRT676620)
- hsa-mir-23a-5p (MIRT676621)
- hsa-mir-6778-3p (MIRT676622)
- hsa-mir-6506-5p (MIRT676623)
- hsa-mir-619-5p (MIRT676624)
- hsa-mir-150-5p (MIRT676625)
- hsa-mir-6747-3p (MIRT676626)
- hsa-mir-6727-3p (MIRT676627)
- hsa-mir-4722-3p (MIRT676628)
- hsa-mir-6814-5p (MIRT676629)
- hsa-mir-1207-3p (MIRT676630)
- hsa-mir-6504-3p (MIRT676631)
- hsa-mir-646 (MIRT676632)
- hsa-mir-6783-3p (MIRT678204)
- hsa-mir-1343-3p (MIRT678205)
- hsa-mir-6742-3p (MIRT678206)
- hsa-mir-6852-5p (MIRT678207)
- hsa-mir-939-3p (MIRT678208)
miRNA Products
- Search ViGene Biosciences for CSNK1E
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CSNK1E
- Browse OriGene Inhibitory RNA Products For CSNK1E
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1E gene
Clone Products
- Sino Biological Human cDNA Clone for CSNK1E
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CSNK1E
- VectorBuilder custom plasmid, inducible vectors for CSNK1E
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK1E
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CSNK1E
-
ViGene Biosciences adenoviral particle packaged cDNA for CSNK1E gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CSNK1E gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1E gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK1E Gene
Localization for CSNK1E Gene
Subcellular locations from UniProtKB/Swiss-Prot for CSNK1E Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IDA | 17244647 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0030426 | growth cone | IEA | -- |
Pathways & Interactions for CSNK1E Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
| 2 | Hedgehog Pathway |
.40
|
|
| 3 | Wnt Signaling Pathway and Pluripotency | ||
| 4 | rRNA processing in the nucleus and cytosol |
.89
|
|
| 5 | Circadian rhythm |
.30
|
|
Pathways by source for CSNK1E Gene
2 Cell Signaling Technology pathways for CSNK1E Gene
10 BioSystems pathways for CSNK1E Gene
22 Reactome pathways for CSNK1E Gene
6 KEGG pathways for CSNK1E Gene
2 GeneGo (Thomson Reuters) pathways for CSNK1E Gene
4 R&D Systems pathways for CSNK1E Gene
2 Tocris pathways for CSNK1E Gene
6 Qiagen pathways for CSNK1E Gene
Interacting Proteins for CSNK1E Gene
Selected Interacting proteins:
P49674-KC1E_HUMAN
ENSP00000352929
for CSNK1E Gene via
MINT
STRING
UniProtKB
IID
SIGNOR curated interactions for CSNK1E Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
| GO:0006281 | DNA repair | TAS | 7797465 |
| GO:0006364 | rRNA processing | TAS | -- |
| GO:0006468 | protein phosphorylation | ISS,TAS | -- |
| GO:0006897 | endocytosis | IBA | -- |
Drugs & Compounds for CSNK1E Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for CSNK1E Gene
mRNA/cDNA for CSNK1E Gene
- (2) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (100) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CSNK1E Gene
CRISPR Products
-
OriGene CRISPR knockouts for CSNK1E
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSNK1E
- GenScript: Design CRISPR guide RNA sequences for CSNK1E
miRNA Products
- Search ViGene Biosciences for CSNK1E
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CSNK1E
- Browse OriGene Inhibitory RNA Products For CSNK1E
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1E gene
Clone Products
- Sino Biological Human cDNA Clone for CSNK1E
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CSNK1E
- VectorBuilder custom plasmid, inducible vectors for CSNK1E
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK1E
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CSNK1E Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Outflow Tract
- Neural Tube (Nervous System)
- Brain (Nervous System)
- Eye (Sensory Organs)
This gene is overexpressed in Breast (22.5), Fetal Brain (21.0), Frontal cortex (11.7), and Heart (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CSNK1E Gene
NURSA nuclear receptor signaling pathways regulating expression of CSNK1E Gene:
CSNK1ESOURCE GeneReport for Unigene cluster for CSNK1E Gene:
Hs.474833mRNA Expression by UniProt/SwissProt for CSNK1E Gene:
P49674-KC1E_HUMAN
Tissue specificity:
Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
Evidence on tissue expression from TISSUES for CSNK1E Gene
- Lung(4.6)
- Nervous system(4.4)
- Liver(4.3)
- Skin(3.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CSNK1E
-
OriGene qPCR primer pairs for CSNK1E
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1E Gene
Orthologs for CSNK1E Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| CSNK1E 35 |
|
OneToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | CSNK1E 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CSNK1E 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CSNK1E 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Csnk1e 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Csnk1e 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CSNK1E 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CSNK1E 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CSNK1E 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | csnk1e 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.553 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | csnk1e 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | dco 36 34 35 |
|
||
| CkIalpha 36 |
|
|
|||
| CG2577 36 |
|
|
|||
| CG7094 36 |
|
|
|||
| CG12147 36 |
|
|
|||
| CG9962 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | kin-20 35 |
|
OneToMany | |
| C55B7.10 36 |
|
|
|||
| spe-6 36 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HRR25 37 |
|
|
|
| thale cress (Arabidopsis thaliana) |
eudicotyledons | ckl12 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os.11642 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9629 35 |
|
OneToMany |
- Species where no ortholog for CSNK1E was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CSNK1E Gene
Paralogs for CSNK1E Gene
(9) SIMAP similar genes for CSNK1E Gene using alignment to 11 proteins:
Variants for CSNK1E Gene
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_042082 | A lung adenocarcinoma sample | ||||
| rs1000114570 | -- | 38,317,554(+) | GCCGC(-/A)GCTGC | intron-variant, upstream-variant-2KB | |
| rs1000213875 | -- | 38,295,400(+) | TCCTG(G/T)GGCCG | intron-variant | |
| rs1000260491 | -- | 38,295,486(+) | GCCTG(C/T)TCATG | intron-variant | |
| rs1000311407 | -- | 38,295,820(+) | GCAGG(A/C)CTGGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv831e199 | CNV | deletion | 23128226 |
| esv2667907 | CNV | deletion | 23128226 |
| esv29271 | CNV | loss | 19812545 |
| esv3647726 | CNV | loss | 21293372 |
| esv3647727 | CNV | loss | 21293372 |
| nsv1072210 | CNV | deletion | 25765185 |
| nsv1072637 | CNV | deletion | 25765185 |
| nsv1072638 | CNV | deletion | 25765185 |
| nsv1126631 | CNV | deletion | 24896259 |
| nsv1143410 | CNV | deletion | 24896259 |
| nsv834195 | CNV | loss | 17160897 |
| nsv964629 | CNV | duplication | 23825009 |
| nsv979674 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.25;
24.99% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CSNK1E Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1E Gene
Disorders for CSNK1E Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| advanced sleep phase syndrome |
|
|
Search CSNK1E in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CSNK1E
No data available for UniProtKB/Swiss-Prot and Genatlas for CSNK1E Gene
Publications for CSNK1E Gene
- Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. (PMID: 7797465) Fish K.J. … Virshup D.M. (J. Biol. Chem. 1995) 2 3 4 22 64
- Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V. … Urretavizcaya M. (Neuropsychopharmacology 2010) 3 22 46 64
- Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. (PMID: 19934327) Zhu Y. … Stanford J.L. (Cancer Res. 2009) 3 22 46 64
- Genetic susceptibility to heroin addiction: a candidate gene association study. (PMID: 18518925) Levran O. … Kreek M.J. (Genes Brain Behav. 2008) 3 22 46 64
- Casein kinase I epsilon (CKIvarepsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders. (PMID: 18571740) Castro R.M. … Tufik S. (Behav. Brain Res. 2008) 3 22 46 64
Products for CSNK1E Gene
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