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Aliases for CSNK1E Gene

Aliases for CSNK1E Gene

  • Casein Kinase 1 Epsilon 2 3
  • Casein Kinase 1, Epsilon 2 3 5
  • CKI-Epsilon 3 4
  • EC 2.7.11.1 4 63
  • CKIe 3 4
  • CKIepsilon 3
  • EC 2.7.11 63
  • HCKIE 3

External Ids for CSNK1E Gene

Previous GeneCards Identifiers for CSNK1E Gene

  • GC22M035302
  • GC22M036929
  • GC22M036930
  • GC22M037011
  • GC22M038686
  • GC22M021653
  • GC22M038397
  • GC22M038521

Summaries for CSNK1E Gene

Entrez Gene Summary for CSNK1E Gene

  • The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CSNK1E Gene

CSNK1E (Casein Kinase 1 Epsilon) is a Protein Coding gene. Diseases associated with CSNK1E include advanced sleep phase syndrome. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for CSNK1E Gene

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.

Gene Wiki entry for CSNK1E Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1E Gene

Genomics for CSNK1E Gene

Regulatory Elements for CSNK1E Gene

Promoters for CSNK1E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CSNK1E on UCSC Golden Path with GeneCards custom track

Genomic Location for CSNK1E Gene

Chromosome:
22
Start:
38,290,691 bp from pter
End:
38,398,522 bp from pter
Size:
107,832 bases
Orientation:
Minus strand

Genomic View for CSNK1E Gene

Genes around CSNK1E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1E Gene

Proteins for CSNK1E Gene

  • Protein details for CSNK1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49674-KC1E_HUMAN
    Recommended name:
    Casein kinase I isoform epsilon
    Protein Accession:
    P49674

    Protein attributes for CSNK1E Gene

    Size:
    416 amino acids
    Molecular mass:
    47315 Da
    Quaternary structure:
    • Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts with ANKRD6, DBNDD2, LRP5, LRP6 and SOCS3. Interacts with SNAI1 (via zinc fingers).
    • Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts with ANKRD6, DBNDD2, LRP5, LRP6 and SOCS3. Interacts with SNAI1 (via zinc fingers).

    Three dimensional structures from OCA and Proteopedia for CSNK1E Gene

neXtProt entry for CSNK1E Gene

Proteomics data for CSNK1E Gene at MOPED

Post-translational modifications for CSNK1E Gene

  • Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.
  • Ubiquitination at Lys 294
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CSNK1E (Casein Kinase 1 epsilon)

Domains & Families for CSNK1E Gene

Gene Families for CSNK1E Gene

Protein Domains for CSNK1E Gene

Graphical View of Domain Structure for InterPro Entry

P49674

UniProtKB/Swiss-Prot:

KC1E_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1E: view

Function for CSNK1E Gene

Molecular function for CSNK1E Gene

GENATLAS Biochemistry:
casein kinase 1,catalytic unit,epsilon 1,involved in the transduction of WNT signal
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation leads to a decrease of the catalytic activity.
UniProtKB/Swiss-Prot Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
UniProtKB/Swiss-Prot Induction:
Down-regulated during granulocytic differentiation.

Enzyme Numbers (IUBMB) for CSNK1E Gene

Gene Ontology (GO) - Molecular Function for CSNK1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CSNK1E: view
genes like me logo Genes that share phenotypes with CSNK1E: view

Animal Models for CSNK1E Gene

MGI Knock Outs for CSNK1E:

Animal Model Products

miRNA for CSNK1E Gene

miRTarBase miRNAs that target CSNK1E

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK1E Gene

Localization for CSNK1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1E Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK1E Gene COMPARTMENTS Subcellular localization image for CSNK1E gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CSNK1E Gene

Pathways & Interactions for CSNK1E Gene

genes like me logo Genes that share pathways with CSNK1E: view

SIGNOR curated interactions for CSNK1E Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CSNK1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006468 protein phosphorylation IEA,ISS --
GO:0006996 organelle organization TAS --
GO:0007165 signal transduction TAS 7797465
GO:0008360 regulation of cell shape IBA --
genes like me logo Genes that share ontologies with CSNK1E: view

Drugs & Compounds for CSNK1E Gene

(5) Drugs for CSNK1E Gene - From: HMDB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
IC261 Experimental Pharma 0

(2) Additional Compounds for CSNK1E Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CSNK1E: view

Transcripts for CSNK1E Gene

Unigene Clusters for CSNK1E Gene

Casein kinase 1, epsilon:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1E Gene

No ASD Table

Relevant External Links for CSNK1E Gene

GeneLoc Exon Structure for
CSNK1E
ECgene alternative splicing isoforms for
CSNK1E

Expression for CSNK1E Gene

mRNA expression in normal human tissues for CSNK1E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSNK1E Gene

This gene is overexpressed in Breast (22.5), Fetal Brain (21.0), Frontal cortex (11.7), and Heart (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CSNK1E Gene



SOURCE GeneReport for Unigene cluster for CSNK1E Gene Hs.474833

mRNA Expression by UniProt/SwissProt for CSNK1E Gene

P49674-KC1E_HUMAN
Tissue specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
genes like me logo Genes that share expression patterns with CSNK1E: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CSNK1E Gene

Orthologs for CSNK1E Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1E Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CSNK1E 35
  • 92.63 (n)
  • 99.28 (a)
CSNK1E 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csnk1e 35
  • 90.71 (n)
  • 98.8 (a)
Csnk1e 16
Csnk1e 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSNK1E 35
  • 99.44 (n)
  • 100 (a)
CSNK1E 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csnk1e 35
  • 90.95 (n)
  • 99.28 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 100 (a)
OneToMany
CSNK1E 36
  • 47 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CSNK1E 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSNK1E 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves CSNK1E 35
  • 83.73 (n)
  • 97.12 (a)
CSNK1E 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSNK1E 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk1e 35
  • 78.45 (n)
  • 96.87 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.553 35
zebrafish
(Danio rerio)
Actinopterygii csnk1e 35
  • 74.48 (n)
  • 84.3 (a)
csnk1e 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12147 37
  • 53 (a)
CG2577 37
  • 58 (a)
CG7094 37
  • 56 (a)
CG9962 37
  • 47 (a)
CkIalpha 37
  • 70 (a)
dco 37
  • 86 (a)
dco 35
  • 76.86 (n)
  • 85.53 (a)
dco 36
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C55B7.10 37
  • 32 (a)
spe-6 37
  • 31 (a)
kin-20 36
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRR25 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ckl12 35
  • 68.81 (n)
  • 77.97 (a)
rice
(Oryza sativa)
Liliopsida Os.11642 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9629 36
  • 79 (a)
OneToMany
Species with no ortholog for CSNK1E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK1E Gene

ENSEMBL:
Gene Tree for CSNK1E (if available)
TreeFam:
Gene Tree for CSNK1E (if available)

Paralogs for CSNK1E Gene

genes like me logo Genes that share paralogs with CSNK1E: view

Variants for CSNK1E Gene

Sequence variations from dbSNP and Humsavar for CSNK1E Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_042082 A lung adenocarcinoma sample
VAR_042083 -

Structural Variations from Database of Genomic Variants (DGV) for CSNK1E Gene

Variant ID Type Subtype PubMed ID
nsv915061 CNV Loss 21882294
nsv915062 CNV Loss 21882294
nsv834195 CNV Loss 17160897

Variation tolerance for CSNK1E Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK1E Gene

HapMap Linkage Disequilibrium report
CSNK1E
Human Gene Mutation Database (HGMD)
CSNK1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1E Gene

Disorders for CSNK1E Gene

MalaCards: The human disease database

(1) MalaCards diseases for CSNK1E Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
advanced sleep phase syndrome
  • familial advanced sleep-phase syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CSNK1E

Genetic Association Database (GAD)
CSNK1E
Human Genome Epidemiology (HuGE) Navigator
CSNK1E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK1E
genes like me logo Genes that share disorders with CSNK1E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSNK1E Gene

Publications for CSNK1E Gene

  1. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. (PMID: 7797465) Fish K.J. … Virshup D.M. (J. Biol. Chem. 1995) 2 3 4 23 67
  2. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V. … Urretavizcaya M. (Neuropsychopharmacology 2010) 3 23
  3. CK1epsilon is required for breast cancers dependent on beta-catenin activity. (PMID: 20126544) Kim S.Y. … Hahn W.C. (PLoS ONE 2010) 3 23
  4. Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity. (PMID: 19043076) Grozav A.G. … Ganapathi M.K. (Nucleic Acids Res. 2009) 3 23
  5. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. (PMID: 19934327) Zhu Y. … Stanford J.L. (Cancer Res. 2009) 3 23

Products for CSNK1E Gene

Sources for CSNK1E Gene

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