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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSNK1E Gene

protein-coding   GIFtS: 66
GCID: GC22M038686

casein kinase 1, epsilon
 Explore 19 diseases affiliated with
CSNK1E via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CSNK1E    

Aliases
for CSNK1E gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Casein Kinase 1, Epsilon1 2     EC 2.7.11.13 8
CKIepsilon1 2     CKIE1
HCKIE1 2     Casein Kinase I Isoform Epsilon2
CKI-Epsilon1     EC 2.7.118
CKIe2 3     

External Ids:    HGNC: 24531   Entrez Gene: 14542   Ensembl: ENSG000002139237   OMIM: 6008635   UniProtKB: P496743   

Export aliases for CSNK1E gene to outside databases

Previous GC identifers: GC22M035302 GC22M036929 GC22M036930 GC22M037011 GC22M021653


Summaries
for CSNK1E gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CSNK1E:
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein
family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA
replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of
proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KC1E_HUMAN, P49674
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins
as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1.
Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating
PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation

Gene Wiki entry for CSNK1E


Genomic Views
for CSNK1E gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSNK1E gene promoter:
         PPAR-gamma1   PPAR-gamma2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CSNK1E promoter sequence
   Search SABiosciences Chromatin IP Primers for CSNK1E

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK1E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

CSNK1E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK1E gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M038686:  view genomic region     (about GC identifiers)

Start:
 38,686,697 bp from pter      End:
 38,794,527 bp from pter
Size:
 107,831 bases      Orientation:
 minus strand

Proteins
for CSNK1E gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KC1E_HUMAN, P49674 (See protein sequence)
Recommended Name: Casein kinase I isoform epsilon  
Size: 416 amino acids; 47315 Da
Subunit: Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1
or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to
their degradation. Interacts with ANKRD6, DBNDD2, LRP5, LRP6 and SOCS3. Interacts with SNAI1 (via zinc fingers)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
2 PDB 3D structures from and Proteopedia for CSNK1E:
4HNI (3D)        4HOK (3D)    

Explore the universe of human proteins at neXtProt for CSNK1E: NX_P49674

Post-translational modifications:

  • Autophosphorylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49674

    • 4/27 DME Specific Peptides for CSNK1E (P49674) (see all 27)
     GEEVAIK  QGGVGIP  LGKKGNL  TKRQKYE 

    CSNK1E Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001885.1  NP_689407.1  

    ENSEMBL proteins: 
     ENSP00000352929   ENSP00000385582   ENSP00000383067   ENSP00000400494   ENSP00000403610  
     ENSP00000384074   ENSP00000412194   ENSP00000407235   ENSP00000384426   ENSP00000397460  
     ENSP00000403057   ENSP00000412335   ENSP00000380044  
    Reactome Protein details: P49674
    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): CSNK1E
    OriGene Protein Over-expression Lysate (see all 2): CSNK1E
    OriGene Custom Protein Services for CSNK1E 
    GenScript Custom Purified and Recombinant Proteins Services for CSNK1E
    Novus Biologicals CSNK1E Proteins
    Novus Biologicals CSNK1E Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005829cytosol TAS--
    GO:0030529ribonucleoprotein complex IEA--


    CSNK1E for ontologies           About GeneDecksing



    CSNK1E Antibody Products: 
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    ThermoFisher Antibodies for CSNK1E

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    Protein Domains /
    Families
    for CSNK1E gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CSNK1E for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P49674

    ProtoNet protein and cluster: P49674

    UniProtKB/Swiss-Prot: KC1E_HUMAN, P49674
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CSNK1E gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KC1E_HUMAN, P49674
    Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins
    as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1.
    Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating
    PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: Down-regulated during granulocytic differentiation

         Genatlas biochemistry entry for CSNK1E:
    casein kinase 1,catalytic unit,epsilon 1,involved in the transduction of WNT signal

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSNK1E
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate CSNK1E (see all 46):
    hsa-miR-548j hsa-miR-607 hsa-miR-4328 hsa-miR-548k hsa-miR-200a hsa-miR-218 hsa-miR-570 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmid: CSNK1E 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSNK1E (see all 7)
    OriGene shRNA RFP: CSNK1E
    OriGene siRNA: CSNK1E
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSNK1E

    Gene Editing
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    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CSNK1E (NM_001894)
    Sino Biological Human cDNA Clone for CSNK1E
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSNK1E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1E 

    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ISS--
    GO:0004674protein serine/threonine kinase activity TAS7797465
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    CSNK1E for ontologies           About GeneDecksing


    7 GenomeRNAi human phenotypes for CSNK1E:
     Decreased Wnt reporter activit  Decreased focal adhesion (FA)   Decreased mitotic index  Decreased substrate adherent c 
     Increased circadian period len  Reduced beta-catenin activity   Stronger migration 

    Animal Models:
         Mouse knock-outs for CSNK1E: Csnk1etm1.1Drw Csnk1etm1.1Asil
         2 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Csnk1e):
     behavior/neurological  no phenotypic analysis 

    CSNK1E for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CSNK1E gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Recruitment of mitotic centrosome proteins and complexes
    		Recruitment of mitotic centrosome proteins and complexes1.00
    		Mitotic G2-G2/M phases0.81
    		Centrosome maturation1.00
    		Loss of proteins required for interphase microtubule organization from the centrosome0.78
    		G2/M Transition0.83
    		Loss of Nlp from mitotic centrosomes0.78
    2Circadian rhythm - mammal
    		Circadian rhythm - mammal1.00
    		Translocation of CRY:PER:Kinase Ternary Complex into the Nucleus0.26
    		Circadian Clock0.41
    		Formation of CRY:PER:Kinase Complex0.26
    		Circadian Clock in Mammals0.40
    3Wnt Signaling Pathway
    		Wnt Signaling Pathway1.00
    		Wnt signaling pathway0.30
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt Signaling Pathway NetPath0.22
    		Wnt Signaling Pathway0.33
    4Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84
    5Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    		Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling1.00
    		Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling0.98

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for CSNK1E
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Translation Regulation activity of EIF2

    1 R&D Systems Pathway for CSNK1E
        Wnt Signaling Pathway

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSNK1E (see all 6)
        GSK3 Signaling
    Circadian Clock in Mammals
    Signaling in Gap Junctions
    WNT Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    2 Cell Signaling Technology (CST) Pathways for CSNK1E
        Wnt / Hedgehog / Notch
    Neuroscience

    2 Tocris Bioscience Pathways for CSNK1E
        Hedgehog Pathway
    Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for CSNK1E
        Translation Regulation of EIF2 activity
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5/8 BioSystems Pathways for CSNK1E (see all 8) 
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath
    FoxO family signaling
    p53 pathway

    5/11        Reactome Pathways for CSNK1E (see all 11)
        Circadian Clock
    Centrosome maturation
    Formation of CRY:PER:Kinase Complex
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes


    3         Kegg Pathways  (Kegg details for CSNK1E):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Circadian rhythm - mammal


    CSNK1E for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSNK1E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/334 Interacting proteins for CSNK1E (P496741, 2, 3 ENSP000003529294) via UniProtKB, MINT, STRING, and/or I2D (see all 334)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    HIST1H4EP628053I2D: score=3 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006281DNA repair TAS7797465
    GO:0006468protein phosphorylation ISS--
    GO:0007165signal transduction TAS7797465


    CSNK1E for ontologies           About GeneDecksing



    Drugs & Compounds
    for CSNK1E gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CSNK1E for compounds           About GeneDecksing

    EMD Millipore small molecules for CSNK1E:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CSNK1E available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PF 4800567Selective casein kinase 1epsilon inhibitor[1188296-52-7]
    (R)-DRF053 dihydrochlorideDual CK1/cdk inhibitor[1056016-06-8]
    D 4476Selective CK1 inhibitor. Also inhibits TGF-betaRI[301836-43-1]
    PF 670462Potent and selective CK1epsilon and CK1delta inhibitor[950912-80-8]

    2 HMDB Compounds for CSNK1E    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    4 Novoseek chemical compound relationships for CSNK1E gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 42.4 1 11524435 (1)
    serine 33.3 7 10542239 (2), 11487578 (1), 11875063 (1), 11475410 (1)
    threonine 31.1 6 10542239 (2), 11875063 (1), 11475410 (1)
    alanine 0 3 10542239 (1), 16513652 (1)

    Search CenterWatch for drugs/clinical trials and news about CSNK1E / KC1E 

    Transcripts
    for CSNK1E gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CSNK1E gene (2 alternative transcripts): 
    NM_001894.4  NM_152221.2  

    Unigene Cluster for CSNK1E:

    Casein kinase 1, epsilon
    Hs.474833  [show with all ESTs]
    Unigene Representative Sequence: NM_152221
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359867(uc003avk.3 uc003avm.2) ENST00000402865 ENST00000400206(uc010gxm.2)
    ENST00000366216 ENST00000431632 ENST00000495232 ENST00000403904 ENST00000431611
    ENST00000494610 ENST00000413574 ENST00000405675 ENST00000498529 ENST00000442216
    ENST00000451964 ENST00000467976 ENST00000430335 ENST00000396832(uc003avj.3)


    miRNA
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    hsa-miR-548j hsa-miR-607 hsa-miR-4328 hsa-miR-548k hsa-miR-200a hsa-miR-218 hsa-miR-570 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmid: CSNK1E 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSNK1E (see all 7)
    OriGene shRNA RFP: CSNK1E
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSNK1E
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CSNK1E (NM_001894)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1E 
    Primer
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    Additional cDNA sequence: 

    AB024597.1 AB091043.1 AK057067.1 AK223498.1 BC006490.2 BC013088.1 BT019831.1 CR456429.1 
    L37043.1 XR_158965.1 XR_159375.1 

    24/42 DOTS entries (see all 42):

    DT.92446756  DT.95170381  DT.100650499  DT.308021  DT.91861089  DT.100650501  DT.448023  DT.95170372 
    DT.100757907  DT.120665210  DT.95249800  DT.100699899  DT.100858817  DT.95170382  DT.100831070  DT.100873290 
    DT.100771514  DT.100866355  DT.99940102  DT.91876099  DT.97855740  DT.100770077  DT.100847709  DT.100876003 

    24/100 AceView cDNA sequences (see all 100):

    BG033119 CR618521 AI828030 BF056111 BM999831 BQ689779 CR619665 BM989377 
    AI301919 BI912803 BG676490 CR601194 BM459275 AB024597 F10003 BU160976 
    BX341526 AI591325 CR601968 BQ424425 CK821728 CR614988 BG574406 CR591261 

    GeneLoc Exon Structure


    Expression
    for CSNK1E gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSNK1E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CSNK1E expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    EyeRetinaEye
    HeartOutflow TractHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CSNK1E Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSNK1E

    SOURCE GeneReport for Unigene cluster: Hs.474833

    UniProtKB/Swiss-Prot: KC1E_HUMAN, P49674
    Tissue specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta
    and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including CSNK1E: 
              Hedgehog Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat

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    Orthologs
    for CSNK1E gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSNK1E gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CSNK1E1 casein kinase 1, epsilon 83.73(n)
    97.12(a)    		   378891  NM_204377.2  NP_989708.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CSNK1E6
    		 --
    		 97(a)
    		 1 ↔ 1
    		 GL343460.1(476431-518227)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.5532 Xenopus laevis casein kinase I epsilon (CKIe) mRNA, more 85.07(n)    AF183394.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii csnk1da1 casein kinase 1, delta a 75.17(n)
    87.37(a)    		   322106  NM_199583.1  NP_955877.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta dco1 , 3 cell communication protein serine/threonine
    kinase3
    discs overgrown1    		 86(a)
    (best of 6)3
    76.69(n)1
    84.97(a)1    		   100B23
    436731  NM_170536.21  NP_733415.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea C55B7.103
    kin-201    		 casein kinase3
    Protein KIN-201    		 32(a)
    (best of 2)3
    66.78(n)1
    79.59(a)1    		   I(6510365-6511942)3
    1816201  NM_001029498.21  NP_001024669.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CKL21 casein kinase 1-like protein 2 68.37(n)
    77.21(a)    		   843603  NM_105930.2  NP_177415.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.116422 Oryza sativa (japonica cultivar-group) putative casein more 75.82(n)    NM_191682.1 


    ENSEMBL Gene Tree for CSNK1E (if available)
    TreeFam Gene Tree for CSNK1E (if available) 

    Paralogs
    for CSNK1E gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSNK1E gene
    VRK32  VRK12  CSNK1G32  VRK22  CSNK1D2  CSNK1A12  CSNK1G22  CSNK1A1L2  
    TTBK12  CSNK1G12  TTBK22  
    9 SIMAP similar genes for CSNK1E using alignment to 11 protein entries:     KC1E_HUMAN (see all proteins):
    CSNK1D    CSNK1A1L    CSNK1A1    CSNK1G1    CSNK1G3    CSNK1G2
    TTBK1    TTBK2    VRK2

    CSNK1E for paralogs           About GeneDecksing



    Genomic Variants
    for CSNK1E gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/523 NCBI SNPs in CSNK1E are shown (see all 523)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs22673831,2
    		C,F,H,--21658277(+) CACTCG/AGTTGC 1 -- ds500113Minor allele frequency- A:0.05NA NS EA WA 1452
    rs1158556001,2
    		C,F,--21659078(+) AGGTGC/TTCCTG 1 -- nc-transcript-variant1Minor allele frequency- T:0.02WA 118
    rs582066851,2
    		C,F,--21659670(+) GCCCTG/CTGGTG 1 -- nc-transcript-variant3Minor allele frequency- C:0.13WA CSA 122
    rs738846761,2
    		C,--21659917(+) CCGACC/TTTGGC 1 -- nc-transcript-variant2Minor allele frequency- T:0.04WA 120
    rs121699561,2
    		--21660279(+) CTGGCA/GACATC 1 -- int10--------
    rs37885401,2
    		C,F,H,--21660563(+) TGTCAT/CGGGGC 1 -- us2k15Minor allele frequency- C:0.04EA NS 1886
    rs10054731,2
    		C,F,O,A,H,--21660766(+) AGAAGA/CAAGCA 1 -- us2k113Minor allele frequency- C:0.09MN NS EA NA WA 1118
    rs115489261,2
    		H--21661213(-) TGACTA/GCGTCT 1 -- us2k14Minor allele frequency- G:0.00NS EA 402
    rs757745951,2
    		F,--21661531(+) CCTCTG/ACTGCT 1 -- us2k12Minor allele frequency- A:0.14CSA WA 124
    rs802078191,2
    		--21661679(+) ATTCAA/GAGGAC 1 -- us2k11Minor allele frequency- G:0.01NA 120

    HapMap Linkage Disequilibrium report for CSNK1E (38686697 - 38794527 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CSNK1E: --
    Human Gene Mutation Database (HGMD): CSNK1E

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    Disorders / Diseases
    for CSNK1E gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CSNK1E for disorders           About GeneDecksing

    OMIM gene information: 600863    OMIM disorders: --

    19 diseases for CSNK1E:    About MalaCards
    advanced sleep phase syndrome    familial adenomatous polyposis    adenomatous polyposis coli    heroin dependence
    autism spectrum disorder    bipolar i disorder    schizoaffective disorder    polyposis
    epithelial ovarian cancer    mood disorder    sleep disorder    bipolar disorder
    ovarian cancer    hermaphroditism    prostate cancer    breast cancer
    prostatitis    schizophrenia    malaria

    1 Novoseek disease relationship for CSNK1E gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial adenomatous polyposis 48.6 1 17131344 (1)

    Genetic Association Database (GAD): CSNK1E
    Human Genome Epidemiology (HuGE) Navigator: CSNK1E (22 documents)

    Export disorders for CSNK1E gene to outside databases

    Publications
    for CSNK1E gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSNK1E gene, integrated from 9 sources (see all 136):
    (articles sorted by number of sources associating them with CSNK1E)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. (PubMed id 7797465)1, 2, 3, 9 Fish K.J.... Virshup D.M. (1995)
    2. Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation. (PubMed id 16513652)1, 2, 9 Swiatek W....Virshup D.M. (2006)
    3. A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders. (PubMed id 15187983)1, 4, 9 Takano A....Ebisawa T. (2004)
    4. Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. (PubMed id 12556519)1, 2, 9 Hino S.... Kikuchi A. (2003)
    5. Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. (PubMed id 15070676)1, 2, 9 Okamura A....Matsui T. (2004)
    6. Association between the casein kinase 1 epsilon gene region and subjective response to D-amphetamine. (PubMed id 16237383)1, 4, 9 Veenstra-VanderWeele J....de Wit H. (2006)
    7. Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon. (PubMed id 10790862)1, 2, 9 Keesler G.A.... Yao Z. (2000)
    8. Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1. (PubMed id 16618118)1, 2 Yin H.... Kuret J. (2006)
    9. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for CSNK1E gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CSNK1E gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1454 HGNC: 2453 AceView: CSNK1E Ensembl:ENSG00000213923 euGenes: HUgn1454
    ECgene: CSNK1E Kegg: 1454 H-InvDB: CSNK1E

    Other Databases showing CSNK1E gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CSNK1E gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSNK1E Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSNK1E Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CSNK1E gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CSNK1E gene:
    Search GeneIP for patents involving CSNK1E

    GeneCards and IP:
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