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CSNK1E Gene

protein-coding   GIFtS: 69
GCID: GC22M038686

Casein Kinase 1, Epsilon

  See CSNK1E-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Casein Kinase 1, Epsilon1 2     CKIepsilon2
CKI-epsilon2 3     HCKIE2
CKIe2 3     Casein Kinase I Isoform Epsilon2
EC 2.7.11.13 8     EC 2.7.118

External Ids:    HGNC: 24531   Entrez Gene: 14542   Ensembl: ENSG000002139237   OMIM: 6008635   UniProtKB: P496743   

Export aliases for CSNK1E gene to outside databases

Previous GC identifers: GC22M035302 GC22M036929 GC22M036930 GC22M037011 GC22M021653


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSNK1E Gene:
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein
family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA
replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a
variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm
protein. Two transcript variants encoding the same protein have been found for this gene. (provided by RefSeq,
Feb 2014)

GeneCards Summary for CSNK1E Gene:
CSNK1E (casein kinase 1, epsilon) is a protein-coding gene. Diseases associated with CSNK1E include advanced sleep phase syndrome. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is VRK3.

UniProtKB/Swiss-Prot: KC1E_HUMAN, P49674
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as
caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling.
Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian
rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced
granuloytic differentiation

Gene Wiki entry for CSNK1E Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSNK1E gene promoter:
         PPAR-gamma1   PPAR-gamma2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CSNK1E promoter sequence
   Search Chromatin IP Primers for CSNK1E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSNK1E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

CSNK1E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK1E gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M038686:  view genomic region     (about GC identifiers)

Start:
38,686,697 bp from pter      End:
38,794,527 bp from pter
Size:
107,831 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KC1E_HUMAN, P49674 (See protein sequence)
Recommended Name: Casein kinase I isoform epsilon  
Size: 416 amino acids; 47315 Da
Subunit: Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2,
BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which
may lead to their degradation. Interacts with ANKRD6, DBNDD2, LRP5, LRP6 and SOCS3. Interacts with SNAI1 (via
zinc fingers)
2 PDB 3D structures from and Proteopedia for CSNK1E:
4HNI (3D)        4HOK (3D)    

Explore the universe of human proteins at neXtProt for CSNK1E: NX_P49674

Explore proteomics data for CSNK1E at MOPED

Post-translational modifications: 

  • Autophosphorylated. Partially dephosphorylated by PPP5C1
  • Ubiquitination2 at Lys263, Lys294
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CSNK1E (P49674) (see all 27)
     GEEVAIK  QGGVGIP  LGKKGNL  TKRQKYE 


    See CSNK1E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001885.1  NP_689407.1  

    ENSEMBL proteins: 
     ENSP00000352929   ENSP00000383067   ENSP00000400494   ENSP00000403610   ENSP00000384074  
     ENSP00000412194   ENSP00000407235   ENSP00000384426   ENSP00000397460   ENSP00000403057  
     ENSP00000412335   ENSP00000380044  
    Reactome Protein details: P49674

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    antibodies-online proteins for CSNK1E (6 products) 

     
    antibodies-online peptides for CSNK1E

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: casein kinase 1, epsilon
    Casein kinase 1 (CK1) family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P49674

    ProtoNet protein and cluster: P49674

    UniProtKB/Swiss-Prot: KC1E_HUMAN, P49674
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I
    subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CSNK1E           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KC1E_HUMAN, P49674
    Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as
    caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling.
    Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian
    rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced
    granuloytic differentiation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylation leads to a decrease of the catalytic activity
    Induction: Down-regulated during granulocytic differentiation

         Genatlas biochemistry entry for CSNK1E:
    casein kinase 1,catalytic unit,epsilon 1,involved in the transduction of WNT signal

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding ----
         
    Find genes that share ontologies with CSNK1E           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for CSNK1E:
     Decreased Wnt reporter activit  Decreased focal adhesion (FA)   Decreased mitotic index  Decreased substrate adherent c 
     Increased circadian period len  Reduced beta-catenin activity   Stronger migration 

         2 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Csnk1e):
     behavior/neurological  no phenotypic analysis 

    Find genes that share phenotypes with CSNK1E           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CSNK1E: Csnk1etm1.1Drw Csnk1etm1.1Asil

       genOway: Develop your customized and physiologically relevant rodent model for CSNK1E

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    Selected qRT-PCR Assays for microRNAs that regulate CSNK1E (see all 46):
    hsa-miR-548j hsa-miR-607 hsa-miR-4328 hsa-miR-548k hsa-miR-200a hsa-miR-218 hsa-miR-570 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidCSNK1E 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KC1E_HUMAN, P49674: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol ----
    GO:0030529ribonucleoprotein complex ----

    Find genes that share ontologies with CSNK1E           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSNK1E About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Circadian rhythm
    Circadian rhythm0.31
    Circadian Clock in Mammals0.31
    3Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    5Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    Wnt Signaling Pathway and Pluripotency0.55


    Find genes that share SuperPaths with CSNK1E           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CSNK1E
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CSNK1E (see all 6)
        GSK3 Signaling
    Circadian Clock in Mammals
    Signaling in Gap Junctions
    WNT Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    2 Cell Signaling Technology (CST) Pathways for CSNK1E
        Wnt / Hedgehog / Notch
    Neuroscience

    2 Tocris Bioscience Pathways for CSNK1E
        Hedgehog Pathway
    Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for CSNK1E
        Translation Regulation of EIF2 activity
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for CSNK1E (see all 8)
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath
    Circadian rhythm pathway
    Canonical Wnt signaling pathway

    2 Sino Biological Pathways for CSNK1E
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    Selected Reactome Pathways for CSNK1E (see all 6)
        Circadian Clock
    WNT mediated activation of DVL
    Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition


    5 Kegg Pathways  (Kegg details for CSNK1E):
        FoxO signaling pathway
    Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Circadian rhythm

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSNK1E: 
              Hedgehog Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CSNK1E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSNK1E (P496741, 2, 3 ENSP000003529294) via UniProtKB, MINT, STRING, and/or I2D (see all 396)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    HIST1H4EP628053I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle ----
    GO:0000278mitotic cell cycle ----
    GO:0006281DNA repair ----
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction ----

    Find genes that share ontologies with CSNK1E           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for CSNK1E (KC1E)

    2 HMDB Compounds for CSNK1E    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    4 Novoseek inferred chemical compound relationships for CSNK1E gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 42.4 1 11524435 (1)
    serine 33.3 7 10542239 (2), 11487578 (1), 11875063 (1), 11475410 (1)
    threonine 31.1 6 10542239 (2), 11875063 (1), 11475410 (1)
    alanine 0 3 10542239 (1), 16513652 (1)



    Find genes that share compounds with CSNK1E           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CSNK1E gene (2 alternative transcripts): 
    NM_001894.4  NM_152221.2  

    Unigene Cluster for CSNK1E:

    Casein kinase 1, epsilon
    Hs.474833  [show with all ESTs]
    Unigene Representative Sequence: NM_152221
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359867(uc003avk.3 uc003avm.2) ENST00000400206(uc010gxm.2)
    ENST00000366216 ENST00000431632 ENST00000495232 ENST00000403904 ENST00000431611
    ENST00000494610 ENST00000413574 ENST00000405675 ENST00000498529 ENST00000442216
    ENST00000451964 ENST00000467976 ENST00000430335 ENST00000396832(uc003avj.3)

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      QuantiTect SYBR Green Assays in human, mouse, rat CSNK1E
      QuantiFast Probe-based Assays in human, mouse, rat CSNK1E

    Additional mRNA sequence: 

    AB024597.1 AB091043.1 AK057067.1 AK223498.1 BC006490.2 BC013088.1 BT019831.1 CR456429.1 
    L37043.1 XR_158965.1 XR_159375.1 

    Selected DOTS entries (see all 42):

    DT.92446756  DT.95170381  DT.100650499  DT.308021  DT.91861089  DT.100650501  DT.95170372  DT.448023 
    DT.100757907  DT.120665210  DT.95170382  DT.95249800  DT.100699899  DT.100858817  DT.100831070  DT.100873290 
    DT.100771514  DT.100866355  DT.99940102  DT.91876099  DT.97855740  DT.100770077  DT.100847709  DT.100876003 

    Selected AceView cDNA sequences (see all 100):

    AI581674 BM556941 AI090109 BM840668 CR599035 BU509736 AK057067 CA443966 
    CR594270 BG679278 AI968610 BG912836 BG031285 CR617099 BU584503 BU585078 
    BF056111 BU168321 BM761879 BX388227 CR618521 F10003 CR609912 CR619665 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSNK1E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CSNK1E Expression
    About this image


    CSNK1E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Cerebral Cortex
    CSNK1E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSNK1E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474833

    UniProtKB/Swiss-Prot: KC1E_HUMAN, P49674
    Tissue specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney,
    placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSNK1E: 
              Hedgehog Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSNK1E gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csnk1e1 , 5 casein kinase 1, epsilon1, 5 90.71(n)1
    98.8(a)1
      15 (37.71 cM)5
    273731  NM_013767.61  NP_038795.31 
     794178565 
    chicken
    (Gallus gallus)
    Aves CSNK1E1 casein kinase 1, epsilon 83.73(n)
    97.12(a)
      378891  NM_204377.2  NP_989708.2 
    lizard
    (Anolis carolinensis)
    Reptilia CSNK1E6
    casein kinase 1, epsilon
    97(a)
    1 ↔ 1
    GL343460.1(472783-524159)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.5532 Xenopus laevis casein kinase I epsilon (CKIe) mRNA, more 85.07(n)    AF183394.1 
    zebrafish
    (Danio rerio)
    Actinopterygii csnk1e1 casein kinase 1, epsilon 74.48(n)
    84.3(a)
      100006858  NM_212747.1  NP_997912.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dco1 , 3 cell communication protein
    serine/threonine kinase3
    discs overgrown1
    86(a)
    (best of 6)3
    76.86(n)1
    85.53(a)1
      100B23
    436731  NM_001276203.11  NP_001263132.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C55B7.103 casein kinase 32(a)
    (best of 2)
      I(6510365-6511942)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ckl121 ckl12 68.81(n)
    77.97(a)
      835804  NM_148142.2  NP_680447.1 
    rice
    (Oryza sativa)
    Liliopsida Os.116422 Oryza sativa (japonica cultivar-group) putative casein more 75.82(n)    NM_191682.1 


    ENSEMBL Gene Tree for CSNK1E (if available)
    TreeFam Gene Tree for CSNK1E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSNK1E gene
    VRK32  VRK12  CSNK1G32  VRK22  CSNK1D2  ENSG000002593162  CSNK1A12  CSNK1G22  
    CSNK1A1L2  TTBK12  CSNK1G12  TTBK22  
    9 SIMAP similar genes for CSNK1E using alignment to 11 protein entries:     KC1E_HUMAN (see all proteins):
    CSNK1D    CSNK1A1L    CSNK1A1    CSNK1G1    CSNK1G3    CSNK1G2
    TTBK1    TTBK2    VRK2

    Find genes that share paralogs with CSNK1E           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSNK1E (see all 555)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0420824
    A lung adenocarcinoma sample4--see VAR_0420822 R L mis40--------
    rs1357501,2
    C,F,O,A,H--22603136(+) GACCTC/GGGCTC 2 -- ds500110Minor allele frequency- G:0.25EA NA NS CSA WA 514
    rs1859457621,2
    --22603137(+) ACCTCA/GGCTCG 2 -- ds50010--------
    rs1150210321,2
    F--22603142(+) GGCTCG/ATCTTG 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1910389331,2
    --22603289(+) CCTTGC/GTTCTC 2 -- ds50010--------
    rs1468689741,2
    C--22603379(+) CCCCC-/GCGTGG
    CACCTGTG
    GCGTG
    2 -- ds50010--------
    rs751542881,2
    C,F--22603529(+) TCCCAA/C/GCAAGA 2 -- ds50011WA 118
    rs1117740081,2
    C,F--22603559(+) GGAGAG/CGCCCT 2 -- ds50011Minor allele frequency- C:0.50NA 2
    rs773162841,2
    F--22603753(+) AAGCTC/TTGCTC 2 -- ut310--------
    rs1386913851,2
    C--22603910(+) GACTCC/TAGGCT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CSNK1E (38686697 - 38794527 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CSNK1E:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834195CNV Loss17160897
    nsv915062CNV Loss21882294
    nsv915061CNV Loss21882294

    Human Gene Mutation Database (HGMD): CSNK1E
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSNK1E
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600863    OMIM disorders: --

    1 disease for CSNK1E:    
    About MalaCards
    advanced sleep phase syndrome


    Find genes that share disorders with CSNK1E           About GenesLikeMe

    1 Novoseek inferred disease relationship for CSNK1E gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial adenomatous polyposis 48.6 1 17131344 (1)

    Genetic Association Database (GAD): CSNK1E
    Human Genome Epidemiology (HuGE) Navigator: CSNK1E (22 documents)

    Export disorders for CSNK1E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSNK1E gene, integrated from 10 sources (see all 146):
    (articles sorted by number of sources associating them with CSNK1E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. (PubMed id 7797465)1, 2, 3, 9 Fish K.J.... Virshup D.M. (J. Biol. Chem. 1995)
    2. Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation. (PubMed id 16513652)1, 2, 9 Swiatek W.... Virshup D.M. (J. Biol. Chem. 2006)
    3. A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders. (PubMed id 15187983)1, 4, 9 Takano A....Ebisawa T. (Neuropsychopharmacology 2004)
    4. Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. (PubMed id 12556519)1, 2, 9 Hino S.... Kikuchi A. (J. Biol. Chem. 2003)
    5. Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. (PubMed id 15070676)1, 2, 9 Okamura A....Matsui T. (Blood 2004)
    6. Association study between casein kinase 1 epsilon gene and methamphetamine dependence. (PubMed id 18991847)1, 4, 9 Kotaka T....Kuroda S. (Ann. N. Y. Acad. Sci. 2008)
    7. Casein kinase I epsilon (CKIvarepsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders. (PubMed id 18571740)1, 4, 9 Castro R.M....Tufik S. (Behav. Brain Res. 2008)
    8. Association between the casein kinase 1 epsilon gene region and subjective response to D-amphetamine. (PubMed id 16237383)1, 4, 9 Veenstra-VanderWeele J....de Wit H. (Neuropsychopharmacology 2006)
    9. Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon. (PubMed id 10790862)1, 2, 9 Keesler G.A.... Yao Z. (NeuroReport 2000)
    10. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PubMed id 20072116)1, 4, 9 Soria V....Urretavizcaya M. (Neuropsychopharmacology 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1454 HGNC: 2453 AceView: CSNK1E Ensembl:ENSG00000213923 euGenes: HUgn1454
    ECgene: CSNK1E Kegg: 1454 H-InvDB: CSNK1E

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CSNK1E Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSNK1E Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSNK1E gene:
    Search GeneIP for patents involving CSNK1E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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