Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CSNK1E Gene

Aliases for CSNK1E Gene

  • Casein Kinase 1, Epsilon 2 3
  • CKI-Epsilon 3 4
  • EC 2.7.11.1 4 64
  • CKIe 3 4
  • Casein Kinase I Isoform Epsilon 3
  • CKIepsilon 3
  • EC 2.7.11 64
  • HCKIE 3

External Ids for CSNK1E Gene

Summaries for CSNK1E Gene

Entrez Gene Summary for CSNK1E Gene

  • The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CSNK1E Gene

CSNK1E (Casein Kinase 1, Epsilon) is a Protein Coding gene. Diseases associated with CSNK1E include advanced sleep phase syndrome. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for CSNK1E Gene

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.

Gene Wiki entry for CSNK1E Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1E Gene

Genomics for CSNK1E Gene

Genomic Location for CSNK1E Gene

Start:
38,290,691 bp from pter
End:
38,398,522 bp from pter
Size:
107,832 bases
Orientation:
Minus strand

Genomic View for CSNK1E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSNK1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1E Gene

Regulatory Elements for CSNK1E Gene

Proteins for CSNK1E Gene

  • Protein details for CSNK1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49674-KC1E_HUMAN
    Recommended name:
    Casein kinase I isoform epsilon
    Protein Accession:
    P49674
    Secondary Accessions:

    Protein attributes for CSNK1E Gene

    Size:
    416 amino acids
    Molecular mass:
    47315 Da
    Quaternary structure:
    • Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts with ANKRD6, DBNDD2, LRP5, LRP6 and SOCS3. Interacts with SNAI1 (via zinc fingers).

    Three dimensional structures from OCA and Proteopedia for CSNK1E Gene

neXtProt entry for CSNK1E Gene

Proteomics data for CSNK1E Gene at MOPED

Post-translational modifications for CSNK1E Gene

  • Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys263 and Lys294

Domains for CSNK1E Gene

Gene Families for CSNK1E Gene

Protein Domains for CSNK1E Gene

UniProtKB/Swiss-Prot:

KC1E_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P49674
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.:
    • P49674
genes like me logo Genes that share domains with CSNK1E: view

Function for CSNK1E Gene

Molecular function for CSNK1E Gene

GENATLAS Biochemistry: casein kinase 1,catalytic unit,epsilon 1,involved in the transduction of WNT signal
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Phosphorylation leads to a decrease of the catalytic activity.
UniProtKB/Swiss-Prot Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
UniProtKB/Swiss-Prot Induction: Down-regulated during granulocytic differentiation.

Enzyme Numbers (IUBMB) for CSNK1E Gene

Gene Ontology (GO) - Molecular Function for CSNK1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity ISS --
GO:0004674 protein serine/threonine kinase activity TAS 7797465
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 11425858
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CSNK1E: view
genes like me logo Genes that share phenotypes with CSNK1E: view

Animal Models for CSNK1E Gene

MGI Knock Outs for CSNK1E:

miRNA for CSNK1E Gene

miRTarBase miRNAs that target CSNK1E

No data available for Transcription Factor Targeting and HOMER Transcription for CSNK1E Gene

Localization for CSNK1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1E Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK1E Gene COMPARTMENTS Subcellular localization image for CSNK1E gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSNK1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with CSNK1E: view

Pathways for CSNK1E Gene

genes like me logo Genes that share pathways with CSNK1E: view

Gene Ontology (GO) - Biological Process for CSNK1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006281 DNA repair TAS 7797465
GO:0006468 protein phosphorylation ISS --
GO:0006897 endocytosis IBA --
genes like me logo Genes that share ontologies with CSNK1E: view

Compounds for CSNK1E Gene

(2) HMDB Compounds for CSNK1E Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(4) Novoseek inferred chemical compound relationships for CSNK1E Gene

Compound -log(P) Hits PubMed IDs
glycogen 42.4 1
serine 33.3 5
threonine 31.1 4
alanine 0 2
genes like me logo Genes that share compounds with CSNK1E: view

Transcripts for CSNK1E Gene

Unigene Clusters for CSNK1E Gene

Casein kinase 1, epsilon:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1E Gene

No ASD Table

Relevant External Links for CSNK1E Gene

GeneLoc Exon Structure for
CSNK1E
ECgene alternative splicing isoforms for
CSNK1E

Expression for CSNK1E Gene

mRNA expression in normal human tissues for CSNK1E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CSNK1E Gene

SOURCE GeneReport for Unigene cluster for CSNK1E Gene Hs.474833

mRNA Expression by UniProt/SwissProt for CSNK1E Gene

P49674-KC1E_HUMAN
Tissue specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes
genes like me logo Genes that share expressions with CSNK1E: view

Orthologs for CSNK1E Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK1E 36
  • 99.44 (n)
  • 100 (a)
CSNK1E 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 100 (a)
OneToMany
CSNK1E 37
  • 47 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CSNK1E 36
  • 92.63 (n)
  • 99.28 (a)
CSNK1E 37
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csnk1e 36
  • 90.71 (n)
  • 98.8 (a)
Csnk1e 16
Csnk1e 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSNK1E 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSNK1E 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csnk1e 36
  • 90.95 (n)
  • 99.28 (a)
chicken
(Gallus gallus)
Aves CSNK1E 36
  • 83.73 (n)
  • 97.12 (a)
CSNK1E 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSNK1E 37
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.553 36
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk1e 36
  • 78.45 (n)
  • 96.87 (a)
zebrafish
(Danio rerio)
Actinopterygii csnk1e 36
  • 74.48 (n)
  • 84.3 (a)
csnk1e 37
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dco 36
  • 76.86 (n)
  • 85.53 (a)
dco 37
  • 63 (a)
OneToMany
CG7094 38
  • 56 (a)
CkIalpha 38
  • 70 (a)
dco 38
  • 86 (a)
CG9962 38
  • 47 (a)
CG12147 38
  • 53 (a)
CG2577 38
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea kin-20 37
  • 48 (a)
OneToMany
C55B7.10 38
  • 32 (a)
spe-6 38
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRR25 39
thale cress
(Arabidopsis thaliana)
eudicotyledons ckl12 36
  • 68.81 (n)
  • 77.97 (a)
rice
(Oryza sativa)
Liliopsida Os.11642 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9629 37
  • 79 (a)
OneToMany
Species with no ortholog for CSNK1E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK1E Gene

ENSEMBL:
Gene Tree for CSNK1E (if available)
TreeFam:
Gene Tree for CSNK1E (if available)

Paralogs for CSNK1E Gene

genes like me logo Genes that share paralogs with CSNK1E: view

Variants for CSNK1E Gene

Sequence variations from dbSNP and Humsavar for CSNK1E Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
VAR_042082 A lung adenocarcinoma sample
VAR_042083 -

Structural Variations from Database of Genomic Variants (DGV) for CSNK1E Gene

Variant ID Type Subtype PubMed ID
nsv915061 CNV Loss 21882294
nsv915062 CNV Loss 21882294
nsv834195 CNV Loss 17160897

Relevant External Links for CSNK1E Gene

HapMap Linkage Disequilibrium report
CSNK1E
Human Gene Mutation Database (HGMD)
CSNK1E

Disorders for CSNK1E Gene

(1) Novoseek inferred disease relationships for CSNK1E Gene

Disease -log(P) Hits PubMed IDs
familial adenomatous polyposis 48.6 1

Relevant External Links for CSNK1E

Genetic Association Database (GAD)
CSNK1E
Human Genome Epidemiology (HuGE) Navigator
CSNK1E
genes like me logo Genes that share disorders with CSNK1E: view

No data available for UniProtKB/Swiss-Prot for CSNK1E Gene

Publications for CSNK1E Gene

  1. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. (PMID: 7797465) Fish K.J. … Virshup D.M. (J. Biol. Chem. 1995) 2 3 4 23
  2. Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon. (PMID: 10790862) Keesler G.A. … Yao Z. (NeuroReport 2000) 3 4 23
  3. Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. (PMID: 12556519) Hino S. … Kikuchi A. (J. Biol. Chem. 2003) 3 4 23
  4. Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation. (PMID: 16513652) Swiatek W. … Virshup D.M. (J. Biol. Chem. 2006) 3 4 23
  5. Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. (PMID: 15070676) Okamura A. … Matsui T. (Blood 2004) 3 4 23

Products for CSNK1E Gene

Sources for CSNK1E Gene

Back to Top

Content