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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSNK1D Gene

protein-coding   GIFtS: 71
GCID: GC17M080203

Casein Kinase 1, Delta

Microbiology & Infectious Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Casein Kinase 1, Delta1 2     ASPS2
Tau-Protein Kinase CSNK1D2 3     CKIdelta2
CKI-delta2 3     FASPS22
CKId2 3     Casein Kinase I Isoform Delta2
HCKID2 3     EC 2.7.11.263
EC 2.7.11.13 8     EC 2.7.118

External Ids:    HGNC: 24521   Entrez Gene: 14532   Ensembl: ENSG000001415517   OMIM: 6008645   UniProtKB: P487303   

Export aliases for CSNK1D gene to outside databases

Previous GC identifers: GC17M079094 GC17M083015 GC17M080732 GC17M080881 GC17M080880 GC17M077795 GC17M075601


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSNK1D Gene:
This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control
of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is highly similar
to the mouse and rat CK1 delta homologs. Two transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CSNK1D Gene: 
CSNK1D (casein kinase 1, delta) is a protein-coding gene. Diseases associated with CSNK1D include advanced sleep phase syndrome, and hermaphroditism, and among its related super-pathways are Wnt signaling pathway and Circadian Clock. GO annotations related to this gene include protein serine/threonine kinase activity and tau-protein kinase activity. An important paralog of this gene is VRK3.

UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730
Function: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes
including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins.
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as
substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2,
DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a
negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2, leading to retain PER1 in the
cytoplasm. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and
subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and
AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling
pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers
down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A
phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle
apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation.
Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate

Gene Wiki entry for CSNK1D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010663.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSNK1D gene promoter:
         GR   NF-1/L   NF-1   AP-1   Pax-5   FOXD3   C/EBPalpha   SRY   NRF-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CSNK1D promoter sequence
   Search SABiosciences Chromatin IP Primers for CSNK1D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK1D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

CSNK1D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK1D gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M080203:  view genomic region     (about GC identifiers)

Start:
80,196,899 bp from pter      End:
80,231,607 bp from pter
Size:
34,709 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730 (See protein sequence)
Recommended Name: Casein kinase I isoform delta  
Size: 415 amino acids; 47330 Da
Subunit: Binds to DNMT1 and MAP1A (By similarity). Monomer. Component of the circadian core oscillator, which
includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins.
Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with MAPT/TAU, SNAPIN,
DBNDD2, AIB1/NCOA3 and ESR1. AKAP9/AKAP450 binding promotes centrosomal subcellular location. Binds to tubulins
in mitotic cells upon DNA damage
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized
at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the
spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase
activity
Developmental stage: Highly present in extravillous trophoblast cells, which are present at the placenta
implantation site and invade the decidua and decidual vessels
Miscellaneous: May be involved in Alzheimer disease by phosphorylating MAPT/TAU (PubMed:17562708)
Caution: Was shown to phosphorylate and activate DCK in vitro but probably not in vivo (PubMed:20637175)
5 PDB 3D structures from and Proteopedia for CSNK1D:
3UYS (3D)        3UYT (3D)        3UZP (3D)        4HGT (3D)        4HNF (3D)    
Secondary accessions: A2I2P2 Q96KZ6 Q9BTN5
Alternative splicing: 2 isoforms:  P48730-1   P48730-2   

Explore the universe of human proteins at neXtProt for CSNK1D: NX_P48730

Explore proteomics data for CSNK1D at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by
    phosphatase-mediated dephosphorylation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48730

  • 4/30 DME Specific Peptides for CSNK1D (P48730) (see all 30)
     GIPTIRW  GEEVAIK  QGGVGIP  LGKKGNL 

    CSNK1D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CSNK1D Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001884.2  NP_620693.1  

    ENSEMBL proteins: 
     ENSP00000462079   ENSP00000381531   ENSP00000324464   ENSP00000376146   ENSP00000463906  
     ENSP00000269361   ENSP00000385769   ENSP00000463757   ENSP00000464551   ENSP00000462144  
    Reactome Protein details: P48730
    Human Recombinant Protein Products for CSNK1D: 
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    Novus Biologicals CSNK1D Proteins
    Novus Biologicals CSNK1D Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005794Golgi apparatus IDA10826492
    GO:0005813centrosome IDA--
    GO:0005819spindle IDA10826492
    GO:0005829cytosol TAS--

    CSNK1D for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: casein kinase 1, delta 
    Casein kinase 1 (CK1) family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P48730

    ProtoNet protein and cluster: P48730

    UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I
    subfamily
    Similarity: Contains 1 protein kinase domain


    CSNK1D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KC1D_HUMAN, P48730
    Function: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes
    including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins.
    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as
    substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2,
    DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a
    negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2, leading to retain PER1 in the
    cytoplasm. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and
    subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and
    AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling
    pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers
    down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A
    phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle
    apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation.
    Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate
    Enzyme regulation: Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of
    the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by
    phosphorylation. Repressed by 3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one (IC261),
    N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide (CKI-7),
    4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide (D4476), 3,4-Diaryl-isoxazoles
    and -imidazoles, and 4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl) pyrimidin-2-ylamine (PF670462, PF670)

         Genatlas biochemistry entry for CSNK1D:
    casein kinase 1,catalytic unit,delta 1,involved in the transduction of WNT signal

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112 EC 2.7.11.261

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS8786104
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16618118
    GO:0005524ATP binding IEA--
         
    CSNK1D for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CSNK1D:
     Decreased substrate adherent c 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Csnk1d):
     behavior/neurological  growth/size  mortality/aging  no phenotypic analysis 

    CSNK1D for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Csnk1dtm1.1Drw for CSNK1D

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CSNK1D 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSNK1D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSNK1D 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSNK1D 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CSNK1D:
    hsa-let-7b (MIRT001640)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSNK1D
    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate CSNK1D (see all 64):
    hsa-miR-548j hsa-miR-4254 hsa-miR-938 hsa-miR-632 hsa-miR-550a* hsa-miR-3116 hsa-miR-548a-5p hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidCSNK1D 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CSNK1D (NM_001893)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1D
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1D


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CSNK1D About   (see all 22)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt Signaling Pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Circadian Clock
    Circadian Clock0.40
    Circadian rhythm0.35
    3Signaling in Gap Junctions
    Signaling in Gap Junctions0.31
    Gap junction0.31
    4Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    Mitotic G2-G2/M phases0.81
    Centrosome maturation0.83
    Loss of Nlp from mitotic centrosomes0.78
    G2/M Transition0.83
    Loss of proteins required for interphase microtubule organization,from the centrosome0.78
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CSNK1D
        Translation Regulation activity of EIF2

    1 R&D Systems Pathway for CSNK1D
        Wnt Signaling Pathway

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSNK1D (see all 6)
        GSK3 Signaling
    p53 Signaling
    Signaling in Gap Junctions
    WNT Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    2 Cell Signaling Technology (CST) Pathways for CSNK1D
        Wnt / Hedgehog / Notch
    Neuroscience

    1 Tocris Bioscience Pathway for CSNK1D
        Hedgehog Pathway

    1 GeneGo (Thomson Reuters) Pathway for CSNK1D
        Translation Regulation of EIF2 activity

    5/6 BioSystems Pathways for CSNK1D (see all 6)
        Integrated Breast Cancer Pathway
    Wnt Signaling Pathway NetPath
    Canonical Wnt signaling pathway
    FoxO family signaling
    p53 pathway

    2 Sino Biological Pathways for CSNK1D 
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    5/9        Reactome Pathways for CSNK1D (see all 9)
        Circadian Clock
    Centrosome maturation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    G2/M Transition


    4         Kegg Pathways  (Kegg details for CSNK1D):
        Hedgehog signaling pathway
    Hippo signaling pathway
    Gap junction
    Circadian rhythm


    CSNK1D for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CSNK1D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/163 Interacting proteins for CSNK1D (P487301, 2, 3 ENSP000003244644) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 3, ENSP000004172814EBI-751621,EBI-389668 I2D: score=2 STRING: ENSP00000417281
    CSNK1EP496742, 3, ENSP000003529294MINT-8387176 I2D: score=1 STRING: ENSP00000352929
    CRAMP1LQ96RY52, 3, ENSP000002939254MINT-8252670 I2D: score=1 STRING: ENSP00000293925
    PER1O155343, ENSP000003144204I2D: score=4 STRING: ENSP00000314420
    GJA1P173023, ENSP000002825614I2D: score=3 STRING: ENSP00000282561
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001934positive regulation of protein phosphorylation IMP--
    GO:0006281DNA repair TAS8786104
    GO:0006468protein phosphorylation IDA16618118

    CSNK1D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CSNK1D for compounds           About GeneDecksing

    EMD Millipore small molecules for CSNK1D:
    Small Molecule - inhibitor
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    2 HMDB Compounds for CSNK1D    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 Novoseek inferred chemical compound relationships for CSNK1D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ic261 95 3 14761950 (1), 11103931 (1), 16027726 (1)
    serine 33.1 1 16027726 (1)

    Search CenterWatch for drugs/clinical trials and news about CSNK1D / KC1D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CSNK1D gene (2 alternative transcripts): 
    NM_001893.4  NM_139062.2  

    Unigene Cluster for CSNK1D:

    Casein kinase 1, delta
    Hs.631725  [show with all ESTs]
    Unigene Representative Sequence: NM_139062
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000584672 ENST00000398519 ENST00000314028(uc002kei.3 uc002kej.3)
    ENST00000581241(uc010dil.3 uc002keh.3) ENST00000584377 ENST00000577578
    ENST00000392334(uc010wvj.2) ENST00000578501 ENST00000581737 ENST00000580784
    ENST00000269361 ENST00000584913 ENST00000403276 ENST00000580565 ENST00000581108
    ENST00000582844 ENST00000578904(uc010dim.1) ENST00000580446
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate CSNK1D (see all 64):
    hsa-miR-548j hsa-miR-4254 hsa-miR-938 hsa-miR-632 hsa-miR-550a* hsa-miR-3116 hsa-miR-548a-5p hsa-miR-374b*
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    Additional mRNA sequence: 

    AB091044.1 AK096950.1 AK128863.1 AK291758.1 AK295638.1 AK296969.1 AK303365.1 AK308852.1 
    AK311248.1 BC003558.1 BC015775.1 BC047000.1 U29171.1 

    24/29 DOTS entries (see all 29):

    DT.95233975  DT.100665142  DT.100872775  DT.454018  DT.100057282  DT.92032849  DT.100051962  DT.100833927 
    DT.91832815  DT.95350220  DT.95298752  DT.100665139  DT.121002050  DT.95261163  DT.100842114  DT.95261164 
    DT.97855745  DT.121002025  DT.100665141  DT.87017155  DT.87017156  DT.95278048  DT.121001918  DT.121002078 

    24/621 AceView cDNA sequences (see all 621):

    AI926021 BU178376 AA704197 CD246013 AA536181 CN480885 BM976166 CD106644 
    BM854749 NM_001893 BG675637 BM423752 CR593622 T34296 BG681672 CF147153 
    BM828594 BQ883881 AI123950 AA235836 CD366501 AW438652 BM685382 BQ643301 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1D (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ·
    SP1:                                                  -     -     -     -     -                       -                       -     -     -                     
    SP2:                                                  -     -     -     -     -                       -                       -     -     -                     
    SP3:                                                  -     -     -     -     -                       -     -     -     -     -     -     -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                          -     -     -                     

    ExUns: 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
    SP1:                    -           -     -           -                                       
    SP2:                    -           -     -           -     -                                 
    SP3:                    -           -     -                                                   
    SP4:                    -           -     -           -                                       
    SP5:                                                                                          


    ECgene alternative splicing isoforms for CSNK1D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSNK1D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGCTTTCT
    CSNK1D Expression
    About this image


    See CSNK1D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSNK1D

    SOURCE GeneReport for Unigene cluster: Hs.631725

    UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730
    Tissue specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney,
    placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in
    splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and
    lymphocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including CSNK1D: 
              Circadian Rhythms in human mouse rat
              Gap Junctions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSNK1D gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csnk1d1 , 5 casein kinase 1, delta1, 5 90.06(n)1
    99.76(a)1
      11 (84.75 cM)5
    1043181  NM_027874.21  NP_082150.11 
     1209617495 
    chicken
    (Gallus gallus)
    Aves CSNK1D1 casein kinase 1, delta 81.62(n)
    97.49(a)
      417378  XM_415634.3  XP_415634.3 
    lizard
    (Anolis carolinensis)
    Reptilia CSNK1D6
    casein kinase 1, delta
    94(a)
    1 ↔ 1
    2(117850235-117888821)
    African clawed frog
    (Xenopus laevis)
    Amphibia csnk1d-prov2 casein kinase 1, delta 78.38(n)    BC044700.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC063953.12   -- 78.95(n)    BC063953.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dco3 cell communication protein
    serine/threonine kinase
    85(a)
    (best of 6)
      100B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea C55B7.103 casein kinase 32(a)
    (best of 2)
      I(6510365-6511942)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRR256
    Protein kinase involved in regulating diverse even...
    41(a)
    1 → many
    XVI(164276-165760)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ckl51 casein kinase I-like 5 64.49(n)
    71.24(a)
      816466  NM_127505.4  NP_179537.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.14832 Transcribed sequence with moderate similarity to protein more 76.15(n)    BE456063.2 


    ENSEMBL Gene Tree for CSNK1D (if available)
    TreeFam Gene Tree for CSNK1D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSNK1D gene
    VRK32  VRK12  CSNK1G32  VRK22  ENSG000002593162  CSNK1A12  CSNK1G22  CSNK1A1L2  
    TTBK12  CSNK1E2  CSNK1G12  TTBK22  
    13 SIMAP similar genes for CSNK1D using alignment to 9 protein entries:     KC1D_HUMAN (see all proteins):
    CSNK1E    CSNK1A1    CSNK1A1L    CSNK1G1    CSNK1G3    STK11
    CSNK1G2    MAPK8    ULK1    STK38L    TTBK2    MAPK3
    TTBK1

    CSNK1D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/851 SNPs in CSNK1D are shown (see all 851)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364514
    Breast cancer samples4--see VAR_0364512 S C mis40--------
    VAR_0290754
    Advanced sleep phase syndrome, familial, 1 (FASPS1)4--see VAR_0290752 T A mis40--------
    rs1048945611,2
    Cpathogenic180223619(-) TCAAAA/GCCAAA 4 T A mis10--------
    rs1897621901,2
    --80200055(+) CCCCGC/GAGGCC 2 -- ds50010--------
    rs1826895131,2
    --80200093(+) TGGGGC/GGGGGG 2 -- ds50010--------
    rs1162833081,2
    C,F--80200151(+) CTCCTG/AGGCTT 2 -- ds50011Minor allele frequency- A:0.08WA 118
    rs1859010311,2
    --80200170(+) CAAGCG/TACAGG 2 -- ds50010--------
    rs1388826491,2
    C--80200462(+) AAAGAA/GGTATT 2 -- ds50010--------
    rs358427551,2
    C--80200484(+) CACCTA/CAACAC 2 -- ds50010--------
    rs1490106231,2
    --80200552(+) GTAGAA/CGTCAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CSNK1D (80196899 - 80231607 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for CSNK1D (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv995451CNV Deletion20482838
    dgv3354n71CNV Loss21882294
    dgv3353n71CNV Loss21882294
    nsv909134CNV Loss21882294
    dgv3356n71CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    dgv3355n71CNV Loss21882294
    nsv909208CNV Loss21882294
    nsv828139CNV Loss20364138


    Human Gene Mutation Database (HGMD): CSNK1D
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600864    OMIM disorders: --

    UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730
  • Advanced sleep phase syndrome, familial, 1 (FASPS1) [MIM:604348]: A disorder characterized by very early
    sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and
    melatonin rhythms. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 15 diseases for CSNK1D:    About MalaCards
    advanced sleep phase syndrome    hermaphroditism    sleep disorder    bipolar i disorder
    brain disease    familial adenomatous polyposis    schizoaffective disorder    bipolar disorder
    alzheimer's disease    thyroid cancer    parkinson's disease    hypoxia
    schizophrenia    thyroiditis    breast cancer


    CSNK1D for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for CSNK1D gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibrillary tangles 47.1 1 10814741 (1)
    brain diseases 45.8 1 10814741 (1)
    familial adenomatous polyposis 44.6 1 11818547 (1)
    neurodegenerative diseases 22.9 2 10814741 (1), 10924763 (1)
    alzheimers disease 21.3 5 14761950 (1), 10814741 (1), 10924763 (1)

    Genetic Association Database (GAD): CSNK1D
    Human Genome Epidemiology (HuGE) Navigator: CSNK1D (8 documents)

    Export disorders for CSNK1D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSNK1D gene, integrated from 9 sources (see all 109):
    (articles sorted by number of sources associating them with CSNK1D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. (PubMed id 14761950)1, 2, 9 Li G....Kuret J. (2004)
    2. Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. (PubMed id 16027726)1, 2, 9 Stoter M....Knippschild U. (2005)
    3. Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle. (PubMed id 9632646)1, 2, 9 Rivers A....Virshup D.M. (1998)
    4. Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization. (PubMed id 8786104)1, 2, 9 Kusuda J.... Hashimoto K. (1996)
    5. Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. (PubMed id 15070676)1, 2, 9 Okamura A....Matsui T. (2004)
    6. Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth. (PubMed id 21422228)1, 2 Greer Y.E. and Rubin J.S. (2011)
    7. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    8. A coordinated phosphorylation by Lats and CK1 regulat es YAP stability through SCF(beta-TRCP). (PubMed id 20048001)1, 2 Zhao B....Guan K.L. (2010)
    9. Casein kinase 1delta activates human recombinant deox ycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity. (PubMed id 20637175)1, 2 Smal C....Bontemps F. (2010)
    10. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (PubMed id 19839995)1, 4 Mansour H.A....Nimgaonkar V.L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1453 HGNC: 2452 AceView: CSNK1D Ensembl:ENSG00000141551 euGenes: HUgn1453
    ECgene: CSNK1D Kegg: 1453 H-InvDB: CSNK1D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSNK1D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSNK1D Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CSNK1D gene:
    Search GeneIP for patents involving CSNK1D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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