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Aliases for CSNK1D Gene

Aliases for CSNK1D Gene

  • Casein Kinase 1 Delta 2 3
  • Casein Kinase 1, Delta 2 3 5
  • Tau-Protein Kinase CSNK1D 3 4
  • EC 2.7.11.1 4 63
  • CKI-Delta 3 4
  • HCKID 3 4
  • CKId 3 4
  • EC 2.7.11.26 4
  • EC 2.7.11 63
  • CKIdelta 3
  • FASPS2 3
  • ASPS 3

External Ids for CSNK1D Gene

Previous GeneCards Identifiers for CSNK1D Gene

  • GC17M079094
  • GC17M083015
  • GC17M080732
  • GC17M080881
  • GC17M080880
  • GC17M077795
  • GC17M080203
  • GC17M075601

Summaries for CSNK1D Gene

Entrez Gene Summary for CSNK1D Gene

  • This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CSNK1D Gene

CSNK1D (Casein Kinase 1 Delta) is a Protein Coding gene. Diseases associated with CSNK1D include advanced sleep-phase syndrome, familial, 2 and advanced sleep phase syndrome. Among its related pathways are Circadian rhythm and Signaling in Gap Junctions. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for CSNK1D Gene

  • Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

Gene Wiki entry for CSNK1D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1D Gene

Genomics for CSNK1D Gene

Regulatory Elements for CSNK1D Gene

Enhancers for CSNK1D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CSNK1D on UCSC Golden Path with GeneCards custom track

Promoters for CSNK1D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CSNK1D on UCSC Golden Path with GeneCards custom track

Genomic Location for CSNK1D Gene

Chromosome:
17
Start:
82,239,023 bp from pter
End:
82,273,742 bp from pter
Size:
34,720 bases
Orientation:
Minus strand

Genomic View for CSNK1D Gene

Genes around CSNK1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1D Gene

Proteins for CSNK1D Gene

  • Protein details for CSNK1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48730-KC1D_HUMAN
    Recommended name:
    Casein kinase I isoform delta
    Protein Accession:
    P48730
    Secondary Accessions:
    • A2I2P2
    • Q96KZ6
    • Q9BTN5

    Protein attributes for CSNK1D Gene

    Size:
    415 amino acids
    Molecular mass:
    47330 Da
    Quaternary structure:
    • Binds to DNMT1 and MAP1A (By similarity). Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with MAPT/TAU, SNAPIN, DBNDD2, AIB1/NCOA3 and ESR1. AKAP9/AKAP450 binding promotes centrosomal subcellular location. Binds to tubulins in mitotic cells upon DNA damage.
    Miscellaneous:
    • May be involved in Alzheimer disease by phosphorylating MAPT/TAU.

    Three dimensional structures from OCA and Proteopedia for CSNK1D Gene

    Alternative splice isoforms for CSNK1D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSNK1D Gene

Proteomics data for CSNK1D Gene at MOPED

Post-translational modifications for CSNK1D Gene

  • Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for CSNK1D (Casein Kinase 1 delta)

Domains & Families for CSNK1D Gene

Gene Families for CSNK1D Gene

Protein Domains for CSNK1D Gene

Graphical View of Domain Structure for InterPro Entry

P48730

UniProtKB/Swiss-Prot:

KC1D_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1D: view

Function for CSNK1D Gene

Molecular function for CSNK1D Gene

GENATLAS Biochemistry:
casein kinase 1,catalytic unit,delta 1,involved in the transduction of WNT signal
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=36.5 uM for alpha-casein {ECO:0000269 PubMed:23636092}; KM=635.8 uM for PER2 peptide {ECO:0000269 PubMed:23636092}; KM=180.6 uM for ATP {ECO:0000269 PubMed:23636092}; Note=Maximal velocity nearly identical for the reactions with alpha-casein and PER2 peptide.;
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [tau protein] = ADP + [tau protein] phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by phosphorylation. Repressed by 3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one (IC261), N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide (CKI-7), 4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide (D4476), 3,4-diaryl-isoxazoles and -imidazoles, and 4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl) pyrimidin-2-ylamine (PF670462, PF670).
UniProtKB/Swiss-Prot Function:
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

Enzyme Numbers (IUBMB) for CSNK1D Gene

Gene Ontology (GO) - Molecular Function for CSNK1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050321 tau-protein kinase activity IEA --
genes like me logo Genes that share ontologies with CSNK1D: view
genes like me logo Genes that share phenotypes with CSNK1D: view

Human Phenotype Ontology for CSNK1D Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CSNK1D Gene

MGI Knock Outs for CSNK1D:

Animal Model Products

  • Taconic Biosciences Mouse Models for CSNK1D

No data available for Transcription Factor Targets and HOMER Transcription for CSNK1D Gene

Localization for CSNK1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1D Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK1D Gene COMPARTMENTS Subcellular localization image for CSNK1D gene
Compartment Confidence
cytoskeleton 5
cytosol 5
golgi apparatus 5
nucleus 5
plasma membrane 5
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSNK1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0005876 spindle microtubule IDA 10826492
GO:0048471 perinuclear region of cytoplasm IDA 16027726
genes like me logo Genes that share ontologies with CSNK1D: view

Pathways & Interactions for CSNK1D Gene

genes like me logo Genes that share pathways with CSNK1D: view

SIGNOR curated interactions for CSNK1D Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CSNK1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006364 rRNA processing TAS --
GO:0006996 organelle organization TAS --
GO:0007030 Golgi organization IMP 24648492
GO:0007165 signal transduction TAS 8786104
genes like me logo Genes that share ontologies with CSNK1D: view

Drugs & Compounds for CSNK1D Gene

(4) Drugs for CSNK1D Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
IC261 Experimental Pharma 0
CASEIN KINASE I INHIBITOR Pharma 0

(1) Additional Compounds for CSNK1D Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CSNK1D: view

Transcripts for CSNK1D Gene

Unigene Clusters for CSNK1D Gene

Casein kinase 1, delta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1D Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4:
SP5: - - -
SP6: - - - -
SP7: - - - - - - - - - - - -
SP8:
SP9:
SP10:
SP11: - - - - - - - - - - - - -
SP12: - - - - - -
SP13: - - -
SP14: - - - -
SP15: -
SP16: -
SP17: - - - - -

ExUns: 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for CSNK1D Gene

GeneLoc Exon Structure for
CSNK1D
ECgene alternative splicing isoforms for
CSNK1D

Expression for CSNK1D Gene

mRNA expression in normal human tissues for CSNK1D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSNK1D Gene

This gene is overexpressed in Breast (29.0) and Lung (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSNK1D Gene



SOURCE GeneReport for Unigene cluster for CSNK1D Gene Hs.631725

mRNA Expression by UniProt/SwissProt for CSNK1D Gene

P48730-KC1D_HUMAN
Tissue specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
genes like me logo Genes that share expression patterns with CSNK1D: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CSNK1D Gene

Orthologs for CSNK1D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1D Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CSNK1D 35
  • 91.07 (n)
  • 98.47 (a)
CSNK1D 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csnk1d 35
  • 90.12 (n)
  • 99.76 (a)
Csnk1d 16
Csnk1d 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSNK1D 35
  • 99.76 (n)
  • 100 (a)
CSNK1D 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csnk1d 35
  • 89.88 (n)
  • 99.76 (a)
cow
(Bos Taurus)
Mammalia CSNK1D 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSNK1D 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSNK1D 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves CSNK1D 35
  • 81.37 (n)
  • 96.14 (a)
CSNK1D 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSNK1D 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk1d 35
  • 78.47 (n)
  • 96.63 (a)
MGC75636 35
African clawed frog
(Xenopus laevis)
Amphibia csnk1d-prov 35
zebrafish
(Danio rerio)
Actinopterygii csnk1db 35
  • 78.89 (n)
  • 94.97 (a)
csnk1da 36
  • 91 (a)
OneToMany
csnk1db 36
  • 92 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12147 37
  • 52 (a)
CG2577 37
  • 59 (a)
CG7094 37
  • 55 (a)
CG9962 37
  • 46 (a)
CkIalpha 37
  • 69 (a)
dco 37
  • 85 (a)
dco 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C55B7.10 37
  • 32 (a)
spe-6 37
  • 30 (a)
kin-20 35
  • 68.48 (n)
  • 80.27 (a)
kin-20 36
  • 48 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL091W 35
  • 63.5 (n)
  • 68.47 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03168g 35
  • 61.47 (n)
  • 68.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRR25 35
  • 61.24 (n)
  • 65.76 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ckl5 35
  • 65.55 (n)
  • 72.82 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9978 35
barley
(Hordeum vulgare)
Liliopsida Hv.1483 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00685 35
  • 70.62 (n)
  • 77.97 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hhp1 35
  • 66.1 (n)
  • 76.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9629 36
  • 78 (a)
OneToMany
Species with no ortholog for CSNK1D:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK1D Gene

ENSEMBL:
Gene Tree for CSNK1D (if available)
TreeFam:
Gene Tree for CSNK1D (if available)

Paralogs for CSNK1D Gene

genes like me logo Genes that share paralogs with CSNK1D: view

Variants for CSNK1D Gene

Sequence variations from dbSNP and Humsavar for CSNK1D Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12444 -- 82,243,005(+) GTCTA(C/T)CTTCA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1804578 -- 82,244,399(-) TCATT(C/T)TGCTA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1130773 -- 82,251,385(-) ATGCT(C/T)AAATT nc-transcript-variant, reference, synonymous-codon
rs1130774 -- 82,249,499(-) CACAG(A/C)CTCCG nc-transcript-variant, reference, missense
rs1130792 -- 82,244,366(+) GTAAA(A/C/G/T)AAAAT intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CSNK1D Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3332n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3341n71 CNV Loss 21882294
dgv3353n71 CNV Loss 21882294
dgv3354n71 CNV Loss 21882294
nsv833572 CNV Loss 17160897
dgv3355n71 CNV Loss 21882294
nsv909208 CNV Loss 21882294
nsv909211 CNV Loss 21882294
esv995451 CNV Deletion 20482838
nsv828138 CNV Gain 20364138
nsv469561 CNV Complex 16826518
nsv828139 CNV Loss 20364138
nsv828140 CNV Gain 20364138
dgv3356n71 CNV Loss 21882294
nsv909217 CNV Loss 21882294

Variation tolerance for CSNK1D Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK1D Gene

HapMap Linkage Disequilibrium report
CSNK1D
Human Gene Mutation Database (HGMD)
CSNK1D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1D Gene

Disorders for CSNK1D Gene

MalaCards: The human disease database

(4) MalaCards diseases for CSNK1D Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
advanced sleep-phase syndrome, familial, 2
  • advanced sleep phase syndrome, familial, 2
advanced sleep phase syndrome
  • familial advanced sleep-phase syndrome
lymphangitis
  • lymphangitis nos
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

KC1D_HUMAN
  • Advanced sleep phase syndrome, familial, 2 (FASPS2) [MIM:615224]: A disorder characterized by very early sleep onset and offset. Individuals are morning larks with a 4 hours advance of the sleep, temperature and melatonin rhythms. {ECO:0000269 PubMed:15800623, ECO:0000269 PubMed:23636092}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CSNK1D

Genetic Association Database (GAD)
CSNK1D
Human Genome Epidemiology (HuGE) Navigator
CSNK1D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK1D
genes like me logo Genes that share disorders with CSNK1D: view

No data available for Genatlas for CSNK1D Gene

Publications for CSNK1D Gene

  1. Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. (PMID: 14761950) Li G. … Kuret J. (J. Biol. Chem. 2004) 3 4 23 67
  2. Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. (PMID: 17131344) Tsai I.C. … Virshup D.M. (Int. J. Cancer 2007) 3 23
  3. Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. (PMID: 16027726) Stoeter M. … Knippschild U. (Oncogene 2005) 3 23
  4. Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. (PMID: 15070676) Okamura A. … Matsui T. (Blood 2004) 3 23
  5. Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. (PMID: 11818547) Gao Z.H. … Virshup D.M. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23

Products for CSNK1D Gene

Sources for CSNK1D Gene

Content