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CSNK1D Gene

protein-coding   GIFtS: 72
GCID: GC17M080203

Casein Kinase 1, Delta

  See CSNK1D-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Casein Kinase 1, Delta1 2     ASPS2 5
Tau-Protein Kinase CSNK1D2 3     FASPS22 5
CKI-delta2 3     CKIdelta2
CKId2 3     Casein Kinase I Isoform Delta2
HCKID2 3     EC 2.7.11.263
EC 2.7.11.13 8     EC 2.7.118

External Ids:    HGNC: 24521   Entrez Gene: 14532   Ensembl: ENSG000001415517   OMIM: 6008645   UniProtKB: P487303   

Export aliases for CSNK1D gene to outside databases

Previous GC identifers: GC17M079094 GC17M083015 GC17M080732 GC17M080881 GC17M080880 GC17M077795 GC17M075601


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSNK1D Gene:
This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control
of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be
involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and
p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs.
Three transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Feb
2014)

GeneCards Summary for CSNK1D Gene:
CSNK1D (casein kinase 1, delta) is a protein-coding gene. Diseases associated with CSNK1D include advanced sleep-phase syndrome, familial, 2, and advanced sleep phase syndrome. GO annotations related to this gene include protein serine/threonine kinase activity and tau-protein kinase activity. An important paralog of this gene is VRK3.

UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730
Function: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes
including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins.
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as
substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2,
DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a
negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2, leading to retain PER1 in the
cytoplasm. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and
subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and
AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling
pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers
down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A
phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle
apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation.
Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate

Gene Wiki entry for CSNK1D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010663.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSNK1D gene promoter:
         GR   NF-1/L   NF-1   AP-1   Pax-5   FOXD3   C/EBPalpha   SRY   NRF-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CSNK1D promoter sequence
   Search Chromatin IP Primers for CSNK1D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSNK1D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

CSNK1D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK1D gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M080203:  view genomic region     (about GC identifiers)

Start:
80,196,899 bp from pter      End:
80,231,607 bp from pter
Size:
34,709 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730 (See protein sequence)
Recommended Name: Casein kinase I isoform delta  
Size: 415 amino acids; 47330 Da
Subunit: Binds to DNMT1 and MAP1A (By similarity). Monomer. Component of the circadian core oscillator, which
includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins.
Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with MAPT/TAU, SNAPIN,
DBNDD2, AIB1/NCOA3 and ESR1. AKAP9/AKAP450 binding promotes centrosomal subcellular location. Binds to tubulins
in mitotic cells upon DNA damage
Developmental stage: Highly present in extravillous trophoblast cells, which are present at the placenta
implantation site and invade the decidua and decidual vessels
Miscellaneous: May be involved in Alzheimer disease by phosphorylating MAPT/TAU (PubMed:17562708)
Caution: Was shown to phosphorylate and activate DCK in vitro but probably not in vivo (PubMed:20637175)
Selected PDB 3D structures from and Proteopedia for CSNK1D (see all 9):
3UYS (3D)        3UYT (3D)        3UZP (3D)        4HGT (3D)        4HNF (3D)        4KB8 (3D)    
Secondary accessions: A2I2P2 Q96KZ6 Q9BTN5
Alternative splicing: 2 isoforms:  P48730-1   P48730-2   

Explore the universe of human proteins at neXtProt for CSNK1D: NX_P48730

Explore proteomics data for CSNK1D at MOPED

Post-translational modifications: 

  • Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by
    phosphatase-mediated dephosphorylation1
  • Ubiquitination2 at Lys263
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CSNK1D (P48730) (see all 30)
     GIPTIRW  GEEVAIK  QGGVGIP  LGKKGNL 


    See CSNK1D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001884.2  NP_620693.1  

    ENSEMBL proteins: 
     ENSP00000462079   ENSP00000381531   ENSP00000324464   ENSP00000376146   ENSP00000463906  
     ENSP00000269361   ENSP00000385769   ENSP00000463757   ENSP00000464551   ENSP00000462144  
    Reactome Protein details: P48730

    CSNK1D Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CSNK1D
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CSNK1D
    GenScript Custom Purified and Recombinant Proteins Services for CSNK1D
    Novus Biologicals CSNK1D Proteins
    Novus Biologicals CSNK1D Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CSNK1D 

    CSNK1D Antibody Products:

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    OriGene Custom Antibody Services for CSNK1D
    Novus Biologicals CSNK1D Antibodies
    Abcam antibodies for CSNK1D
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CSNK1D
    LSBio Antibodies in human, mouse, rat for CSNK1D

    CSNK1D Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript CSNK1D-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CSNK1D 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: casein kinase 1, delta
    Casein kinase 1 (CK1) family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P48730

    ProtoNet protein and cluster: P48730

    UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I
    subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CSNK1D           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KC1D_HUMAN, P48730
    Function: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes
    including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins.
    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as
    substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2,
    DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a
    negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2, leading to retain PER1 in the
    cytoplasm. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and
    subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and
    AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling
    pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers
    down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A
    phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle
    apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation.
    Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate
    Enzyme regulation: Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of
    the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by
    phosphorylation. Repressed by 3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one (IC261),
    N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide (CKI-7),
    4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide (D4476), 3,4-diaryl-isoxazoles
    and -imidazoles, and 4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl) pyrimidin-2-ylamine (PF670462, PF670)
    Biophysicochemical properties: Kinetic parameters: KM=36.5 uM for alpha-casein; KM=635.8 uM for PER2 peptide;
    KM=180.6 uM for ATP; Note=Maximal velocity nearly identical for the reactions with alpha-casein and PER2 peptide;

         Genatlas biochemistry entry for CSNK1D:
    casein kinase 1,catalytic unit,delta 1,involved in the transduction of WNT signal

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112 EC 2.7.11.261

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IEA--
    GO:0004672protein kinase activity TAS8786104
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16618118
         
    Find genes that share ontologies with CSNK1D           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CSNK1D:
     Decreased substrate adherent c 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Csnk1d):
     behavior/neurological  growth/size/body  mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with CSNK1D           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Csnk1dtm1.1Drw for CSNK1D

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CSNK1D
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CSNK1D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSNK1D
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSNK1D

    miRNA
    Products:
        
    miRTarBase miRNAs that target CSNK1D:
    hsa-mir-590-3p (MIRT016176), hsa-let-7b-5p (MIRT001640)

    Block miRNA regulation of human, mouse, rat CSNK1D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSNK1D (see all 64):
    hsa-miR-548j hsa-miR-4254 hsa-miR-938 hsa-miR-632 hsa-miR-550a* hsa-miR-3116 hsa-miR-548a-5p hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidCSNK1D 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CSNK1D

    Gene Editing
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    Clone
    Products:
         
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    GenScript: all cDNA clones in your preferred vector (see all 2): CSNK1D (NM_001893)
    Sino Biological Human cDNA Clone for CSNK1D
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSNK1D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1D
    Addgene plasmids for CSNK1D 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CSNK1D 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KC1D_HUMAN, P48730: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized
    at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the
    spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase
    activity
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    nucleus5
    plasma membrane5
    cytosol4
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005794Golgi apparatus IDA10826492
    GO:0005813centrosome IDA--
    GO:0005819spindle IDA10826492
    GO:0005829cytosol TAS--

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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSNK1D About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt Signaling Pathways0.40
    Wnt Signaling Pathway NetPath0.37
    2Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    3Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    5Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53


    Find genes that share SuperPaths with CSNK1D           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CSNK1D
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CSNK1D (see all 6)
        GSK3 Signaling
    p53 Signaling
    Signaling in Gap Junctions
    WNT Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    2 Cell Signaling Technology (CST) Pathways for CSNK1D
        Wnt / Hedgehog / Notch
    Neuroscience

    1 Tocris Bioscience Pathway for CSNK1D
        Hedgehog Pathway

    1 GeneGo (Thomson Reuters) Pathway for CSNK1D
        Translation Regulation of EIF2 activity

    Selected BioSystems Pathways for CSNK1D (see all 6)
        Integrated Breast Cancer Pathway
    Wnt Signaling Pathway NetPath
    Canonical Wnt signaling pathway
    FoxO family signaling
    p53 pathway

    2 Sino Biological Pathways for CSNK1D
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    5 Reactome Pathways for CSNK1D
        Circadian Clock
    Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    Loss of Nlp from mitotic centrosomes


    4 Kegg Pathways  (Kegg details for CSNK1D):
        Hedgehog signaling pathway
    Hippo signaling pathway
    Gap junction
    Circadian rhythm

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSNK1D: 
              Circadian Rhythms in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CSNK1D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSNK1D (P487301, 2, 3 ENSP000003244644) via UniProtKB, MINT, STRING, and/or I2D (see all 233)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 3, ENSP000004172814EBI-751621,EBI-389668 I2D: score=2 STRING: ENSP00000417281
    CSNK1EP496742, 3, ENSP000003529294MINT-8387176 I2D: score=1 STRING: ENSP00000352929
    CRAMP1LQ96RY52, 3, ENSP000002939254MINT-8252670 I2D: score=1 STRING: ENSP00000293925
    DVL1O146403, ENSP000003681694I2D: score=4 STRING: ENSP00000368169
    PER1O155343, ENSP000003144204I2D: score=4 STRING: ENSP00000314420
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001934positive regulation of protein phosphorylation IMP--
    GO:0006281DNA repair TAS8786104
    GO:0006468protein phosphorylation IDA16618118

    Find genes that share ontologies with CSNK1D           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CSNK1D (KC1D)

    2 HMDB Compounds for CSNK1D    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 Novoseek inferred chemical compound relationships for CSNK1D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ic261 95 3 14761950 (1), 11103931 (1), 16027726 (1)
    serine 33.1 1 16027726 (1)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CSNK1D gene (2 alternative transcripts): 
    NM_001893.4  NM_139062.2  

    Unigene Cluster for CSNK1D:

    Casein kinase 1, delta
    Hs.631725  [show with all ESTs]
    Unigene Representative Sequence: NM_139062
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000584672 ENST00000398519 ENST00000314028(uc002kei.3 uc002kej.3)
    ENST00000581241(uc010dil.3 uc002keh.3) ENST00000584377 ENST00000577578
    ENST00000392334(uc010wvj.2) ENST00000578501 ENST00000581737 ENST00000580784
    ENST00000269361 ENST00000584913 ENST00000403276 ENST00000580565 ENST00000581108
    ENST00000582844 ENST00000578904(uc010dim.1) ENST00000580446
    miRNA
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    Block miRNA regulation of human, mouse, rat CSNK1D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSNK1D (see all 64):
    hsa-miR-548j hsa-miR-4254 hsa-miR-938 hsa-miR-632 hsa-miR-550a* hsa-miR-3116 hsa-miR-548a-5p hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidCSNK1D 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): CSNK1D (NM_001893)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSNK1D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1D
    Addgene plasmids for CSNK1D 
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      QuantiTect SYBR Green Assays in human, mouse, rat CSNK1D
      QuantiFast Probe-based Assays in human, mouse, rat CSNK1D

    Additional mRNA sequence: 

    AB091044.1 AK096950.1 AK128863.1 AK291758.1 AK295638.1 AK296969.1 AK303365.1 AK308852.1 
    AK311248.1 BC003558.1 BC015775.1 BC047000.1 U29171.1 

    Selected DOTS entries (see all 29):

    DT.95233975  DT.100665142  DT.100872775  DT.454018  DT.100057282  DT.92032849  DT.100051962  DT.100833927 
    DT.91832815  DT.95350220  DT.95298752  DT.100665139  DT.121002050  DT.95261163  DT.100842114  DT.95261164 
    DT.97855745  DT.121002025  DT.100665141  DT.87017155  DT.87017156  DT.95278048  DT.121001918  DT.121002078 

    Selected AceView cDNA sequences (see all 621):

    CR600739 CR618512 AI091138 BU730323 BQ941012 BU753604 AI081494 BU741745 
    AA536181 CN480885 CD516071 BG105907 AA704197 CB127992 BQ643301 BQ423417 
    AK096950 BQ220121 AI086842 W42863 BC047000 BU731145 AW474713 AL079805 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1D (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ·
    SP1:                                                  -     -     -     -     -                       -                       -     -     -                     
    SP2:                                                  -     -     -     -     -                       -                       -     -     -                     
    SP3:                                                  -     -     -     -     -                       -     -     -     -     -     -     -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                          -     -     -                     

    ExUns: 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
    SP1:                    -           -     -           -                                       
    SP2:                    -           -     -           -     -                                 
    SP3:                    -           -     -                                                   
    SP4:                    -           -     -           -                                       
    SP5:                                                                                          


    ECgene alternative splicing isoforms for CSNK1D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSNK1D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGCTTTCT
    CSNK1D Expression
    About this image


    CSNK1D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    CSNK1D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSNK1D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631725

    UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730
    Tissue specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney,
    placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in
    splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and
    lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSNK1D: 
              Circadian Rhythms in human mouse rat
              Gap Junctions in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat CSNK1D
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSNK1D gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csnk1d1 , 5 casein kinase 1, delta1, 5 90.12(n)1
    99.76(a)1
      11 (84.75 cM)5
    1043181  NM_139059.21  NP_620690.11 
     1209617495 
    chicken
    (Gallus gallus)
    Aves CSNK1D1 casein kinase 1, delta 81.37(n)
    96.14(a)
      417378  XM_415634.4  XP_415634.3 
    lizard
    (Anolis carolinensis)
    Reptilia CSNK1D6
    casein kinase 1, delta
    94(a)
    1 ↔ 1
    2(117850235-117888821)
    African clawed frog
    (Xenopus laevis)
    Amphibia csnk1d-prov2 casein kinase 1, delta 78.38(n)    BC044700.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC063953.12   -- 78.95(n)    BC063953.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dco3 cell communication protein
    serine/threonine kinase
    85(a)
    (best of 6)
      100B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea C55B7.103
    kin-201
    casein kinase3
    kin-201
    32(a)
    (best of 2)3
    68.48(n)1
    80.27(a)1
      I(6510365-6511942)3
    1816201  NM_182447.61  NP_872247.41 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRR251 HRR25 61.24(n)
    65.76(a)
      855897   NP_015120.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ckl51 ckl5 65.55(n)
    72.82(a)
      816466  NM_127505.4  NP_179537.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.14832 Transcribed sequence with moderate similarity to protein more 76.15(n)    BE456063.2 


    ENSEMBL Gene Tree for CSNK1D (if available)
    TreeFam Gene Tree for CSNK1D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSNK1D gene
    VRK32  VRK12  CSNK1G32  VRK22  ENSG000002593162  CSNK1A12  CSNK1G22  CSNK1A1L2  
    TTBK12  CSNK1E2  CSNK1G12  TTBK22  
    13 SIMAP similar genes for CSNK1D using alignment to 9 protein entries:     KC1D_HUMAN (see all proteins):
    CSNK1E    CSNK1A1    CSNK1A1L    CSNK1G3    CSNK1G1    STK11
    CSNK1G2    MAPK8    ULK1    STK38L    TTBK2    MAPK3
    TTBK1

    Find genes that share paralogs with CSNK1D           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSNK1D (see all 852)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0698014
    Advanced sleep phase syndrome, familial, 2 (FASPS2)4--see VAR_0698012 H R mis40--------
    VAR_0364514
    Breast cancer samples4--see VAR_0364512 S C mis40--------
    VAR_0290754
    Advanced sleep phase syndrome, familial, 2 (FASPS2)4--see VAR_0290752 T A mis40--------
    rs1048945611,2
    Cpathogenic180223619(-) TCAAAA/GCCAAA 4 T A mis10--------
    rs1897621901,2
    --80200055(+) CCCCGC/GAGGCC 2 -- ds50010--------
    rs1826895131,2
    --80200093(+) TGGGGC/GGGGGG 2 -- ds50010--------
    rs1162833081,2
    C,F--80200151(+) CTCCTG/AGGCTT 2 -- ds50011Minor allele frequency- A:0.08WA 118
    rs1859010311,2
    --80200170(+) CAAGCG/TACAGG 2 -- ds50010--------
    rs1388826491,2
    C--80200462(+) AAAGAA/GGTATT 2 -- ds50010--------
    rs358427551,2
    C--80200484(+) CACCTA/CAACAC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for CSNK1D (80196899 - 80231607 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CSNK1D (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv995451CNV Deletion20482838
    dgv3354n71CNV Loss21882294
    dgv3353n71CNV Loss21882294
    nsv909134CNV Loss21882294
    dgv3356n71CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    dgv3355n71CNV Loss21882294
    nsv909208CNV Loss21882294
    nsv828139CNV Loss20364138

    Human Gene Mutation Database (HGMD): CSNK1D
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSNK1D
    DNA2.0 Custom Variant and Variant Library Synthesis for CSNK1D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600864   
    OMIM disorders: 615224  
    UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730
  • Advanced sleep phase syndrome, familial, 2 (FASPS2) [MIM:615224]: A disorder characterized by very early
    sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and
    melatonin rhythms. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 3 diseases for CSNK1D:    
    About MalaCards
    advanced sleep-phase syndrome, familial, 2    advanced sleep phase syndrome    familial advanced sleep phase syndrome 1


    Find genes that share disorders with CSNK1D           About GenesLikeMe

    5 Novoseek inferred disease relationships for CSNK1D gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibrillary tangles 47.1 1 10814741 (1)
    brain diseases 45.8 1 10814741 (1)
    familial adenomatous polyposis 44.6 1 11818547 (1)
    neurodegenerative diseases 22.9 2 10814741 (1), 10924763 (1)
    alzheimers disease 21.3 5 14761950 (1), 10814741 (1), 10924763 (1)

    Genetic Association Database (GAD): CSNK1D
    Human Genome Epidemiology (HuGE) Navigator: CSNK1D (8 documents)

    Export disorders for CSNK1D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CSNK1D gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with CSNK1D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. (PubMed id 14761950)1, 2, 9 Li G.... Kuret J. (J. Biol. Chem. 2004)
    2. Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. (PubMed id 16027726)1, 2, 9 Stoeter M.... Knippschild U. (Oncogene 2005)
    3. Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle. (PubMed id 9632646)1, 2, 9 Rivers A.... Virshup D.M. (J. Biol. Chem. 1998)
    4. Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization. (PubMed id 8786104)1, 2, 9 Kusuda J.... Hashimoto K. (Genomics 1996)
    5. Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. (PubMed id 15070676)1, 2, 9 Okamura A....Matsui T. (Blood 2004)
    6. Casein kinase idelta mutations in familial migraine and advanced phase. (PubMed id 23636092)1, 2 Brennan K.C.... Ptacek L.J. (Sci. Transl. Med. 2013)
    7. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    8. Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a- dependent neurite outgrowth. (PubMed id 21422228)1, 2 Greer Y.E. and Rubin J.S. (J. Cell Biol. 2011)
    9. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). (PubMed id 20048001)1, 2 Zhao B.... Guan K.-L. (Genes Dev. 2010)
    10. Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity. (PubMed id 20637175)1, 2 Smal C.... Bontemps F. (Arch. Biochem. Biophys. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1453 HGNC: 2452 AceView: CSNK1D Ensembl:ENSG00000141551 euGenes: HUgn1453
    ECgene: CSNK1D Kegg: 1453 H-InvDB: CSNK1D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CSNK1D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSNK1D Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSNK1D gene:
    Search GeneIP for patents involving CSNK1D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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