Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CSNK1D Gene

Aliases for CSNK1D Gene

  • Casein Kinase 1 Delta 2 3 5
  • Tau-Protein Kinase CSNK1D 3 4
  • EC 2.7.11.1 4 58
  • CKI-Delta 3 4
  • HCKID 3 4
  • CKId 3 4
  • Casein Kinase I Isoform Delta 3
  • Casein Kinase 1, Delta 2
  • Casein Kinase I 3
  • EC 2.7.11.26 4
  • EC 2.7.11 58
  • CKIdelta 3
  • FASPS2 3
  • ASPS 3

External Ids for CSNK1D Gene

Previous GeneCards Identifiers for CSNK1D Gene

  • GC17M079094
  • GC17M083015
  • GC17M080732
  • GC17M080881
  • GC17M080880
  • GC17M077795
  • GC17M080203
  • GC17M075601

Summaries for CSNK1D Gene

Entrez Gene Summary for CSNK1D Gene

  • This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CSNK1D Gene

CSNK1D (Casein Kinase 1 Delta) is a Protein Coding gene. Diseases associated with CSNK1D include Advanced Sleep-Phase Syndrome, Familial, 2 and Advanced Sleep Phase Syndrome. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Hedgehog Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1E.

UniProtKB/Swiss-Prot for CSNK1D Gene

  • Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

Gene Wiki entry for CSNK1D Gene

Additional gene information for CSNK1D Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1D Gene

Genomics for CSNK1D Gene

Regulatory Elements for CSNK1D Gene


Enhancers around CSNK1D on UCSC Golden Path with GeneCards custom track

Promoters for CSNK1D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000099562 642 1401 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for CSNK1D Gene

Chromosome:
17
Start:
82,239,023 bp from pter
End:
82,273,742 bp from pter
Size:
34,720 bases
Orientation:
Minus strand

Genomic View for CSNK1D Gene

Genes around CSNK1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1D Gene

Proteins for CSNK1D Gene

  • Protein details for CSNK1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48730-KC1D_HUMAN
    Recommended name:
    Casein kinase I isoform delta
    Protein Accession:
    P48730
    Secondary Accessions:
    • A2I2P2
    • Q96KZ6
    • Q9BTN5

    Protein attributes for CSNK1D Gene

    Size:
    415 amino acids
    Molecular mass:
    47330 Da
    Quaternary structure:
    • Binds to DNMT1 and MAP1A (By similarity). Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with MAPT/TAU, SNAPIN, DBNDD2, AIB1/NCOA3 and ESR1. AKAP9/AKAP450 binding promotes centrosomal subcellular location. Binds to tubulins in mitotic cells upon DNA damage.
    Miscellaneous:
    • May be involved in Alzheimer disease by phosphorylating MAPT/TAU.

    Three dimensional structures from OCA and Proteopedia for CSNK1D Gene

    Alternative splice isoforms for CSNK1D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSNK1D Gene

Selected DME Specific Peptides for CSNK1D Gene

P48730:
  • GEEVAIK
  • GIPTIRW
  • QGGVGIP
  • LGKKGNL
  • TKRQKYE
  • RERKVSMRLHRGAP
  • RVASSGL
  • ESLGYVL
  • RGLPSTASGRLRGTQEV
  • RSLRFDDKPDY
  • RKIGSGSFG
  • LFRNLFHR
  • SSSDLTGRQ
  • EQSRRDDLE
  • DLESLGY
  • LTGTARY
  • LPWQGLKA
  • QKYERISEKK
  • IHRDVKPDN
  • TKHPQLHIESK
  • PDNFLMG
  • LADQMISRI
  • TPIEVLC
  • LKTVLLLADQ
  • YLRQLFR
  • LLGPSLEDLF
  • DFGLAKKYRD
  • IIDFGLA
  • RKFSLKT
  • GIEQSRRDD

Post-translational modifications for CSNK1D Gene

  • Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for CSNK1D (Casein Kinase 1 delta)
  • Cell Signaling Technology (CST) Antibodies for CSNK1D (CK1D)

Domains & Families for CSNK1D Gene

Gene Families for CSNK1D Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for CSNK1D Gene

Graphical View of Domain Structure for InterPro Entry

P48730

UniProtKB/Swiss-Prot:

KC1D_HUMAN :
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1D: view

Function for CSNK1D Gene

Molecular function for CSNK1D Gene

GENATLAS Biochemistry:
casein kinase 1,catalytic unit,delta 1,involved in the transduction of WNT signal
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=36.5 uM for alpha-casein {ECO:0000269 PubMed:23636092}; KM=635.8 uM for PER2 peptide {ECO:0000269 PubMed:23636092}; KM=180.6 uM for ATP {ECO:0000269 PubMed:23636092}; Note=Maximal velocity nearly identical for the reactions with alpha-casein and PER2 peptide.;
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [tau protein] = ADP + [tau protein] phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by phosphorylation. Repressed by 3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one (IC261), N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide (CKI-7), 4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide (D4476), 3,4-diaryl-isoxazoles and -imidazoles, and 4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl) pyrimidin-2-ylamine (PF670462, PF670).
UniProtKB/Swiss-Prot Function:
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

Enzyme Numbers (IUBMB) for CSNK1D Gene

Phenotypes From GWAS Catalog for CSNK1D Gene

Gene Ontology (GO) - Molecular Function for CSNK1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity TAS,IEA 8786104
GO:0004674 protein serine/threonine kinase activity TAS,IDA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CSNK1D: view
genes like me logo Genes that share phenotypes with CSNK1D: view

Human Phenotype Ontology for CSNK1D Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CSNK1D Gene

MGI Knock Outs for CSNK1D:

Animal Model Products

  • Taconic Biosciences Mouse Models for CSNK1D

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CSNK1D
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Transcription Factor Targets and HOMER Transcription for CSNK1D Gene

Localization for CSNK1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1D Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1D gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 5
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CSNK1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IBA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA,IEA 10826492
genes like me logo Genes that share ontologies with CSNK1D: view

Pathways & Interactions for CSNK1D Gene

genes like me logo Genes that share pathways with CSNK1D: view

SIGNOR curated interactions for CSNK1D Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CSNK1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0001934 positive regulation of protein phosphorylation IMP 20412773
GO:0006364 rRNA processing TAS --
GO:0006468 protein phosphorylation IEA,ISS --
GO:0006897 endocytosis IBA --
genes like me logo Genes that share ontologies with CSNK1D: view

Drugs & Compounds for CSNK1D Gene

(6) Drugs for CSNK1D Gene - From: ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
IC261 Experimental Pharma 0
D4476 Pharma CK1/ALK5 inhibitor,specific and cell permeable, Selective CK1 inhibitor. Also inhibits TGF-betaRI 0
LH846 Pharma Casein kinases inhibitor, Selective casein kinase 1delta inhibitor 0
CASEIN KINASE I INHIBITOR Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for CSNK1D Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(2) ApexBio Compounds for CSNK1D Gene

Compound Action Cas Number
D4476 CK1/ALK5 inhibitor,specific and cell permeable 301836-43-1
LH846 Casein kinases inhibitor 639052-78-1
genes like me logo Genes that share compounds with CSNK1D: view

Drug Products

Transcripts for CSNK1D Gene

Unigene Clusters for CSNK1D Gene

Casein kinase 1, delta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CSNK1D
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1D Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4:
SP5: - - -
SP6: - - - -
SP7: - - - - - - - - - - - -
SP8:
SP9:
SP10:
SP11: - - - - - - - - - - - - -
SP12: - - - - - -
SP13: - - -
SP14: - - - -
SP15: -
SP16: -
SP17: - - - - -

ExUns: 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for CSNK1D Gene

GeneLoc Exon Structure for
CSNK1D
ECgene alternative splicing isoforms for
CSNK1D

Expression for CSNK1D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSNK1D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSNK1D Gene

This gene is overexpressed in Breast (29.0) and Lung (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSNK1D Gene



NURSA nuclear receptor signaling pathways regulating expression of CSNK1D Gene:

CSNK1D

SOURCE GeneReport for Unigene cluster for CSNK1D Gene:

Hs.631725

mRNA Expression by UniProt/SwissProt for CSNK1D Gene:

P48730-KC1D_HUMAN
Tissue specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.

Evidence on tissue expression from TISSUES for CSNK1D Gene

  • Nervous system(5)
  • Liver(4.3)
  • Spleen(4.3)
  • Lung(3.4)
  • Eye(2.8)
  • Kidney(2.6)
  • Skin(2.5)
  • Blood(2.2)
  • Intestine(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1D Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
Organs:
Head and neck:
  • brain
  • ear
  • head
  • mouth
  • pharynx
Thorax:
  • heart
General:
  • blood vessel
  • skin
genes like me logo Genes that share expression patterns with CSNK1D: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CSNK1D Gene

Orthologs for CSNK1D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSNK1D 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSNK1D 33 34
  • 99.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CSNK1D 34
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSNK1D 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSNK1D 33 34
  • 91.07 (n)
mouse
(Mus musculus)
Mammalia Csnk1d 33 16 34
  • 90.12 (n)
rat
(Rattus norvegicus)
Mammalia Csnk1d 33
  • 89.88 (n)
chicken
(Gallus gallus)
Aves CSNK1D 33 34
  • 81.37 (n)
lizard
(Anolis carolinensis)
Reptilia CSNK1D 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk1d 33
  • 78.47 (n)
MGC75636 33
African clawed frog
(Xenopus laevis)
Amphibia csnk1d-prov 33
zebrafish
(Danio rerio)
Actinopterygii csnk1da 34
  • 91 (a)
OneToMany
csnk1db 33 34
  • 78.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta dco 35 34
  • 85 (a)
CkIalpha 35
  • 69 (a)
CG2577 35
  • 59 (a)
CG7094 35
  • 55 (a)
CG12147 35
  • 52 (a)
CG9962 35
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea kin-20 33 34
  • 68.48 (n)
C55B7.10 35
  • 32 (a)
spe-6 35
  • 30 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL091W 33
  • 63.5 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03168g 33
  • 61.47 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRR25 33
  • 61.24 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ckl5 33
  • 65.55 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9978 33
barley
(Hordeum vulgare)
Liliopsida Hv.1483 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9629 34
  • 78 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00685 33
  • 70.62 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hhp1 33
  • 66.1 (n)
Species where no ortholog for CSNK1D was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK1D Gene

ENSEMBL:
Gene Tree for CSNK1D (if available)
TreeFam:
Gene Tree for CSNK1D (if available)

Paralogs for CSNK1D Gene

genes like me logo Genes that share paralogs with CSNK1D: view

Variants for CSNK1D Gene

Sequence variations from dbSNP and Humsavar for CSNK1D Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs104894561 Pathogenic, Advanced sleep phase syndrome, familial, 2 (FASPS2) [MIM:615224] 82,265,743(-) TCAAA(A/G)CCAAA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs397514693 Pathogenic, Advanced sleep phase syndrome, familial, 2 (FASPS2) [MIM:615224] 82,265,736(-) CAAAC(A/G)CCCTC nc-transcript-variant, reference, missense, utr-variant-5-prime
VAR_036451 Breast cancer samples
rs1000015641 -- 82,246,256(+) CTTGC(G/T)CTTAA intron-variant, nc-transcript-variant
rs1000041621 -- 82,244,390(+) AATAA(C/T)TTTTA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CSNK1D Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv2760445 CNV gain 21179565
esv2762577 CNV gain+loss 21179565
esv3376470 CNV duplication 20981092
esv995451 CNV deletion 20482838
nsv428351 CNV gain 18775914
nsv469561 CNV loss 16826518
nsv828138 CNV gain 20364138
nsv828139 CNV loss 20364138
nsv828140 CNV gain 20364138
nsv833572 CNV loss 17160897

Variation tolerance for CSNK1D Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK1D Gene

Human Gene Mutation Database (HGMD)
CSNK1D
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK1D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1D Gene

Disorders for CSNK1D Gene

MalaCards: The human disease database

(3) MalaCards diseases for CSNK1D Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
advanced sleep-phase syndrome, familial, 2
  • advanced sleep phase syndrome 2
advanced sleep phase syndrome
  • familial advanced sleep-phase syndrome
lymphangitis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

KC1D_HUMAN
  • Advanced sleep phase syndrome, familial, 2 (FASPS2) [MIM:615224]: A disorder characterized by very early sleep onset and offset. Individuals are morning larks with a 4 hours advance of the sleep, temperature and melatonin rhythms. {ECO:0000269 PubMed:15800623, ECO:0000269 PubMed:23636092}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CSNK1D

Genetic Association Database (GAD)
CSNK1D
Human Genome Epidemiology (HuGE) Navigator
CSNK1D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK1D
genes like me logo Genes that share disorders with CSNK1D: view

No data available for Genatlas for CSNK1D Gene

Publications for CSNK1D Gene

  1. Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. (PMID: 16027726) Stöter M … Knippschild U (Oncogene 2005) 3 4 22 60
  2. Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. (PMID: 15070676) Okamura A … Matsui T (Blood 2004) 3 4 22 60
  3. Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. (PMID: 14761950) Li G … Kuret J (The Journal of biological chemistry 2004) 3 4 22 60
  4. Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle. (PMID: 9632646) Rivers A … Virshup DM (The Journal of biological chemistry 1998) 3 4 22 60
  5. Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization. (PMID: 8786104) Kusuda J … Hashimoto K (Genomics 1996) 3 4 22 60

Products for CSNK1D Gene

Sources for CSNK1D Gene