CSNK1D Gene
protein-coding GIFtS: 69
GCID: GC17M080203
|
|
casein kinase 1, delta
| |
Aliases
for CSNK1D gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Casein Kinase 1, Delta1 2 | | EC 2.7.11.13 8 | | HCKID1 2 3 | | CKID1 | | CKIdelta1 2 | | Casein Kinase I Isoform Delta2 | | Tau-Protein Kinase CSNK1D2 3 | | EC 2.7.11.263 | | CKI-Delta1 | | EC 2.7.118 | | CKId2 3 | | |
Export aliases for CSNK1D gene to outside databasesPrevious GC identifers: GC17M079094 GC17M083015 GC17M080732 GC17M080881 GC17M080880 GC17M077795 GC17M075601 |
Summaries
for CSNK1D gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CSNK1D:
This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control ofcytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is highly similar to themouse and rat CK1 delta homologs. Two transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730Function: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processesincluding Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Caseinkinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1,AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negativeregulator of circadian rhythmicity by phosphorylating PER1 and PER2, leading to retain PER1 in the cytoplasm. YAP1phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation.DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates theiractivity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neuriteoutgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in theforebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation.May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptictransmission mediated by glutamate
Gene Wiki entry for CSNK1D
|
Genomic Views
for CSNK1D gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010663.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CSNK1D gene promoter:
GR NF-1/L NF-1 AP-1 Pax-5 FOXD3 C/EBPalpha SRY NRF-2 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for CSNK1D
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK1D |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25CSNK1D Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M080203: view genomic region
(about GC identifiers)
Start:
|
80,196,899 bp from pter |
End:
|
80,231,607 bp from pter |
Size:
|
34,709 bases |
Orientation:
|
minus strand |
|
Proteins
for CSNK1D gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730 (See
protein sequence)Recommended Name: Casein kinase I isoform delta Size: 415 amino acids; 47330 Da
Subunit: Binds to DNMT1 and MAP1A (By similarity). Monomer. Component of the circadian core oscillator, which includesthe CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interactsdirectly with PER1 and PER2 which may lead to their degradation. Interacts with MAPT/TAU, SNAPIN, DBNDD2, AIB1/NCOA3and ESR1. AKAP9/AKAP450 binding promotes centrosomal subcellular location. Binds to tubulins in mitotic cells upon DNAdamage
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, perinuclear region. Cellmembrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized at mitotic spindle microtubules, and atthe centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in responseto DNA-damage. Correct subcellular localization requires kinase activity
Developmental stage: Highly present in extravillous trophoblast cells, which are present at the placenta implantationsite and invade the decidua and decidual vessels
Miscellaneous: May be involved in Alzheimer disease by phosphorylating MAPT/TAU (PubMed:17562708)
Caution: Was shown to phosphorylate and activate DCK in vitro but probably not in vivo (PubMed:20637175)
5 PDB 3D structures from  and Proteopedia  for CSNK1D:3UYS (3D)
3UYT (3D)
3UZP (3D)
4HGT (3D)
4HNF (3D)
Secondary accessions: A2I2P2 Q96KZ6 Q9BTN5Alternative splicing: 2 isoforms: P48730-1 P48730-2 Explore the universe of human proteins at neXtProt for CSNK1D: NX_P48730
Post-translational modifications:
Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated byphosphatase-mediated dephosphorylation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P48730
4/30 DME Specific Peptides for CSNK1D (P48730) (see all 30)
CSNK1D Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001884.2 NP_620693.1
ENSEMBL proteins: ENSP00000462079 ENSP00000381531 ENSP00000324464 ENSP00000376146 ENSP00000463906 ENSP00000269361 ENSP00000385769 ENSP00000463757 ENSP00000464551 ENSP00000462144 Reactome Protein details: P48730
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
CSNK1D for ontologies About GeneDecksing
CSNK1D Antibody Products:
Assay Products for CSNK1D: |
Protein
Domains /
Families
for CSNK1D gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CSNK1D for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P48730ProtoNet protein and cluster: P48730 UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamilySimilarity: Contains 1 protein kinase domain |
Function
for CSNK1D gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730Function: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processesincluding Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Caseinkinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1,AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negativeregulator of circadian rhythmicity by phosphorylating PER1 and PER2, leading to retain PER1 in the cytoplasm. YAP1phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation.DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates theiractivity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neuriteoutgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in theforebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation.May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptictransmission mediated by glutamateCatalytic activity: ATP + a protein = ADP + a phosphoproteinCatalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphateEnzyme regulation: Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of theoscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited byphosphorylation. Repressed by 3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one (IC261),N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide (CKI-7),4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide (D4476), 3,4-Diaryl-isoxazoles and-imidazoles, and 4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl) pyrimidin-2-ylamine (PF670462, PF670) Genatlas biochemistry entry for CSNK1D:casein kinase 1,catalytic unit,delta 1,involved in the transduction of WNT signal
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112 EC 2.7.11.261
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1D (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1D (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CSNK1D (NM_001893) | |  | Sino Biological Human cDNA Clone for CSNK1D | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CSNK1D | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1D |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1D |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
CSNK1D for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CSNK1D:
Animal Models:
Mouse knock-out Csnk1dtm1.1Drw for CSNK1D
4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Csnk1d):
CSNK1D for phenotypes About GeneDecksing
|
Pathways & Interactions
for CSNK1D gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Recruitment of mitotic centrosome proteins and complexes | | | 2 | Circadian rhythm - mammal | | | 3 | Cell Cycle | | | 4 | Signaling in Gap Junctions | | | 5 | Wnt Signaling Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CSNK1D
1  R&D Systems Pathway for CSNK1D
5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSNK1D (see all 6)
2 
Cell Signaling Technology (CST) Pathways for CSNK1D
1  Tocris Bioscience Pathway for CSNK1D
1  GeneGo (Thomson Reuters) Pathway for CSNK1D
5/6  BioSystems Pathways for CSNK1D (see all 6)
5/11 
Reactome Pathways for CSNK1D (see all 11)
3 
Kegg Pathways (Kegg details for CSNK1D):
CSNK1D for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CSNK1D
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/163 Interacting proteins for CSNK1D (P487301, 2, 3 ENSP000003244644) via UniProtKB, MINT, STRING, and/or I2D (see all 163)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
CSNK1D for ontologies About GeneDecksing
|
Drugs & Compounds
for CSNK1D gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CSNK1D for compounds About GeneDecksing
Compounds for CSNK1D available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| (R)-DRF053 dihydrochloride | Dual CK1/cdk inhibitor | [1056016-06-8] | | D 4476 | Selective CK1 inhibitor. Also inhibits TGF-betaRI | [301836-43-1] | | PF 670462 | Potent and selective CK1epsilon and CK1delta inhibitor | [950912-80-8] |
2 HMDB Compounds for CSNK1D About this table
2 Novoseek chemical compound relationships for CSNK1D gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ic261 |
95 |
3 |
14761950 (1), 11103931 (1), 16027726 (1) |
| serine |
33.1 |
1 |
16027726 (1) |
Search CenterWatch for drugs/clinical trials and news about CSNK1D / KC1D
|
Transcripts
for CSNK1D gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CSNK1D gene (2 alternative transcripts): NM_001893.4 NM_139062.2 Unigene Cluster for CSNK1D: Casein kinase 1, delta Hs.631725 [show with all ESTs]Unigene Representative Sequence: NM_13906218/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26): ENST00000584672 ENST00000398519 ENST00000314028(uc002kei.3 uc002kej.3)
ENST00000581241(uc010dil.3 uc002keh.3) ENST00000584377 ENST00000577578
ENST00000392334(uc010wvj.2) ENST00000578501 ENST00000581737 ENST00000580784
ENST00000269361 ENST00000584913 ENST00000403276 ENST00000580565 ENST00000581108
ENST00000582844 ENST00000578904(uc010dim.1) ENST00000580446
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1D (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1D (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CSNK1D (NM_001893) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CSNK1D | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1D |
Additional cDNA sequence: AB091044.1 AK096950.1 AK128863.1 AK291758.1 AK295638.1 AK296969.1 AK303365.1 AK308852.1 AK311248.1 BC003558.1 BC015775.1 BC047000.1 U29171.1 24/30 DOTS entries (see all 30): DT.95233975 DT.100665142 DT.100872775 DT.454018 DT.100057282 DT.92032849 DT.100051962 DT.100833927 DT.91832815 DT.95350220 DT.95298752 DT.100665139 DT.121002050 DT.95261163 DT.100842114 DT.95261164 DT.97855745 DT.121002025 DT.100665141 DT.87017155 DT.87017156 DT.95278048 DT.121001918 DT.121002078 24/621 AceView cDNA sequences (see all 621): BF794695 BU172246 AA740409 AA192381 CK299239 AU185091 BM423752 BU731145 BQ690863 BQ643301 BC047000 CF528471 BQ941012 BU753604 CR618512 AL079805 CD516071 BU522050 BX456878 BQ883881 BM685382 BI523597 AI245968 AW474713
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1D (see all 17) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | |
| ExUns: | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | · | 15d | · | 15e |
|---|
|
| SP1: | | | | | | | - | | | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CSNK1D
|
Expression
for CSNK1D gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CSNK1D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGCTTTCT
About this image
See CSNK1D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CSNK1D
SOURCE GeneReport for Unigene cluster: Hs.631725
UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730Tissue specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placentaand skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood,highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes
SABiosciences Expression via Pathway-Focused PCR Arrays including CSNK1D:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSNK1D
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSNK1D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSNK1D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSNK1D | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1D |
Orthologs
for CSNK1D gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CSNK1D gene from 8/34 species (see all 34) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CSNK1D1 |
casein kinase 1, delta |
81.62(n)
97.49(a) |
|
417378 XM_415634.3 XP_415634.3 |
lizard
(Anolis carolinensis) |
Reptilia |
CSNK1D6 |
-- |
96(a) |
1 ↔ 1 |
2(117850483-117867085) |
African clawed frog
(Xenopus laevis) |
Amphibia |
csnk1d-prov2 |
casein kinase 1, delta |
78.38(n) |
|
BC044700.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC063953.12 |
-- |
78.95(n) |
|
BC063953.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
dco3 |
cell communication protein serine/threonine
kinase |
85(a)
(best of 6) |
|
100B2 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
C55B7.103 |
casein kinase |
32(a)
(best of 2) |
|
I(6510365-6511942) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ckl51 |
casein kinase I-like 5 |
64.49(n)
71.24(a) |
|
816466 NM_127505.4 NP_179537.1 |
rice
(Oryza sativa) |
Liliopsida |
----(see all 9) |
CK1_CaseinKinase_1.3 - CK1 includes the casein kin...CK1_CaseinKinase_1.2 - CK1 includes the casein kin...(see all 9) |
52(a)51(a)(see all 9) |
many ↔ manymany ↔ many(see all 9) |
1(29430556-29435421) 1(21877943-21882992) |
ENSEMBL Gene Tree for CSNK1D (if available)
TreeFam Gene Tree for CSNK1D (if available) |
Paralogs
for CSNK1D gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CSNK1D gene
- VRK32 VRK12 CSNK1G32 VRK22 CSNK1A12 CSNK1G22 CSNK1A1L2 TTBK12
- CSNK1G12 CSNK1E2 TTBK22
13 SIMAP similar genes for CSNK1D using alignment to 9 protein entries: KC1D_HUMAN (see all proteins):CSNK1E CSNK1A1 CSNK1A1L CSNK1G1 CSNK1G3 STK11
CSNK1G2 MAPK8 ULK1 STK38L TTBK2 MAPK3
TTBK1
CSNK1D for paralogs About GeneDecksing
|
Genomic Variants
for CSNK1D gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CSNK1D (80196899 - 80231607 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CSNK1D
3 CNVs: 5043 73078 73079
1 Indel: 34300
Human Gene Mutation Database (HGMD): CSNK1D
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSNK1D |
|
Disorders
/ Diseases
for CSNK1D gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CSNK1D for disorders About GeneDecksing
OMIM gene information: 600864
OMIM disorders: --
UniProtKB/Swiss-Prot: KC1D_HUMAN, P48730
Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS ischaracterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of thesleep, temperature and melatonin rhythms
16  diseases for CSNK1D: About MalaCardsadvanced sleep phase syndrome familial adenomatous polyposis bipolar i disorder schizoaffective disorder
neurodegenerative disease polyposis sleep disorder brain disease
bipolar disorder alzheimer's disease parkinson's disease hermaphroditism
breast cancer hypoxia schizophrenia malaria
5 Novoseek disease relationships for CSNK1D gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| neurofibrillary tangles |
47.1 |
1 |
10814741 (1) |
| brain diseases |
45.8 |
1 |
10814741 (1) |
| familial adenomatous polyposis |
44.6 |
1 |
11818547 (1) |
| neurodegenerative diseases |
22.9 |
2 |
10814741 (1), 10924763 (1) |
| alzheimers disease |
21.3 |
5 |
14761950 (1), 10814741 (1), 10924763 (1) |
Human Genome Epidemiology (HuGE) Navigator: CSNK1D (8 documents)
Export disorders for CSNK1D gene to outside databases
|
Publications
for CSNK1D gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CSNK1D gene, integrated from 9 sources (see all 104):
(articles sorted by number of sources associating them with CSNK1D) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. (PubMed id 14761950)1, 2, 9 Li G....Kuret J. (2004)
- Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. (PubMed id 16027726)1, 2, 9 Stoter M....Knippschild U. (2005)
- Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle. (PubMed id 9632646)1, 2, 9 Rivers A....Virshup D.M. (1998)
- Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization. (PubMed id 8786104)1, 2, 9 Kusuda J.... Hashimoto K. (1996)
- Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. (PubMed id 15070676)1, 2, 9 Okamura A....Matsui T. (2004)
- Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth. (PubMed id 21422228)1, 2 Greer Y.E. and Rubin J.S. (2011)
- A coordinated phosphorylation by Lats and CK1 regulat es YAP stability through SCF(beta-TRCP). (PubMed id 20048001)1, 2 Zhao B....Guan K.L. (2010)
- Casein kinase 1delta activates human recombinant deox ycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity. (PubMed id 20637175)1, 2 Smal C....Bontemps F. (2010)
- Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. (PubMed id 17962809)1, 2 von Blume J....Seufferlein T. (2007)
- Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. (PubMed id 17562708)1, 2 Hanger D.P....Anderton B.H. (2007)
|
External Searches for CSNK1D gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CSNK1D gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CSNK1D gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CSNK1D gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CSNK1D gene:
Search GeneIP for patents involving CSNK1D
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CSNK1D gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for CSNK1D | | OriGene shRNA RFP for CSNK1D | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSNK1D | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSNK1D | | | OriGene Protein Over-expression Lysate for CSNK1D | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CSNK1D | | OriGene 3'-UTR Clone for CSNK1D | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1D | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1D | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CSNK1D | | OriGene Custom Protein Services for CSNK1D | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CSNK1D | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSNK1D | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK1D | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSNK1D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSNK1D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSNK1D |
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| | Antibodies & Assays for CSNK1D (CK1-D) |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1D |
|  |  |  | | | | ThermoFisher Antibodies for CSNK1D |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1D |
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